Loading...

Lusis Aldons

TitleProfessor
InstitutionUniversity of California Los Angeles
DepartmentMedicine
AddressMRL 3-730
Los Angeles CA 90095
Phone310-825-2957
vCardDownload vCard
    Other Positions
    TitleProfessor

    TitleProfessor

    TitleVice Chair


    Collapse Research 
    Collapse Research Activities and Funding
    Pharmacogenomics of Statin Therapy
    NIH/NIGMS P50GM115318Sep 7, 2015 - Aug 31, 2020
    Role: Co-Principal Investigator
    Systems Genetics Approach to Atherosclerosis
    NIH/NHLBI R01HL126753Mar 9, 2015 - Jan 31, 2019
    Role: Principal Investigator
    A Systems Approach to Dissect Genetic Basis of Heart Failure
    NIH/NHLBI R01HL123295Apr 1, 2014 - Mar 31, 2018
    Role: Co-Principal Investigator
    Systems Approach to Unraveling the Genetic Basis of Heart Failure
    NIH/NHLBI R01HL114437Sep 4, 2013 - May 31, 2017
    Role: Co-Principal Investigator
    Systems Genetics of Type 1 Diabetes Complications
    NIH/NIDDK DP3DK094311Sep 30, 2011 - Jun 30, 2016
    Role: Principal Investigator
    A Systems Approach to Uncover Novel Genes and Networks in Heart Failure
    NIH/NHLBI R21HL110667Aug 15, 2011 - Jul 31, 2013
    Role: Principal Investigator
    Dissection of HDL function using mouse models
    NIH/NHLBI R01HL094322Jul 15, 2009 - Apr 30, 2014
    Role: Principal Investigator
    Integrative genetic approaches to Atherosclerosis
    NIH/NHLBI R01HL095154Jul 15, 2009 - Jun 30, 2011
    Role: Principal Investigator
    Genetic Analysis of the Diabetes-Prone C57BLKS Strain
    NIH/NIDDK R01DK071673Aug 15, 2005 - Jun 30, 2010
    Role: Principal Investigator
    LIPOPROTEIN METABOLISM GENETIC CONTROL--MOUSE MODEL
    NIH/NHLBI R37HL042488Jul 1, 1989 - May 31, 2000
    Role: Principal Investigator
    LIPOPROTEIN METABOLISM GENETIC CONTROL--MOUSE MODEL
    NIH/NHLBI R01HL042488Jul 1, 1989 - May 30, 1999
    Role: Principal Investigator
    Molecular Genetic Approaches in Atherosclerosis Research
    NIH/NHLBI P01HL028481Jul 1, 1983 - Apr 30, 2020
    Role: Principal Investigator
    CONTROL OF GRANULOPOIESIS: MOLECULAR GENETIC APPROACH
    NIH/NIADDK R01AM027008Jan 1, 1981 - Dec 31, 1988
    Role: Principal Investigator
    CONTROL OF GRANULOPOIESIS: MOLECULAR GENETIC APPROACH
    NIH/NIDDK R01DK027008Jan 1, 1981 - Dec 31, 1988
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Erbilgin A, Seldin MM, Wu X, Mehrabian M, Zhou Z, Qi H, Dabirian KS, Sevag Packard RR, Hsieh W, Bensinger SJ, Sinha S, Lusis A. Transcription Factor Zhx2 Deficiency Reduces Atherosclerosis and Promotes Macrophage Apoptosis in Mice. Arterioscler Thromb Vasc Biol. 2018 Jul 19. PMID: 30026271.
      View in: PubMed
    2. Park S, Ranjbarvazirj S, Lay FD, Zhao P, Miller MJ, Dhaliwal JS, Huertas-Vazquez A, Wu X, Qiao R, Soffer JM, Mikkola HKA, Lusis A, Ardehali R. Genetic Regulation of Fibroblast Activation and Proliferation in Cardiac Fibrosis. Circulation. 2018 Jun 27. PMID: 29950403.
      View in: PubMed
    3. Hui ST, Kurt Z, Tuominen I, Norheim F, Davis RC, Pan C, Dirks DL, Magyar CE, French SW, Chella Krishnan K, Sabir S, Campos-Pérez F, Méndez-Sánchez N, Macías-Kauffer L, León-Mimila P, Canizales-Quinteros S, Yang X, Beaven SW, Huertas-Vazquez A, Lusis A. The Genetic Architecture of Diet-induced Hepatic Fibrosis in Mice. Hepatology. 2018 Jun 16. PMID: 29907965.
      View in: PubMed
    4. Hitzel J, Lee E, Zhang Y, Bibli SI, Li X, Zukunft S, Pflüger B, Hu J, Schürmann C, Vasconez AE, Oo JA, Kratzer A, Kumar S, Rezende F, Josipovic I, Thomas D, Giral H, Schreiber Y, Geisslinger G, Fork C, Yang X, Sigala F, Romanoski CE, Kroll J, Jo H, Landmesser U, Lusis A, Namgaladze D, Fleming I, Leisegang MS, Zhu J, Brandes RP. Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells. Nat Commun. 2018 Jun 12; 9(1):2292. PMID: 29895827.
      View in: PubMed
    5. Orozco LD, Farrell C, Hale C, Rubbi L, Rinaldi A, Civelek M, Pan C, Lam L, Montoya D, Edillor C, Seldin M, Boehnke M, Mohlke KL, Jacobsen S, Kuusisto J, Laakso M, Lusis A, Pellegrini M. Epigenome-wide association in adipose tissue from the METSIM cohort. Hum Mol Genet. 2018 Jun 09. PMID: 29893869.
      View in: PubMed
    6. Orozco LD, Farrell C, Hale C, Rubbi L, Rinaldi A, Civelek M, Pan C, Lam L, Montoya D, Edillor C, Seldin M, Boehnke M, Mohlke KL, Jacobsen S, Kuusisto J, Laakso M, Lusis A, Pellegrini M. Epigenome-wide association in adipose tissue from the METSIM cohort. Hum Mol Genet. 2018 May 15; 27(10):1830-1846. PMID: 29566149.
      View in: PubMed
    7. Norheim F, Bjellaas T, Hui ST, Chella Krishnan K, Lee J, Gupta S, Pan C, Hasin-Brumshtein Y, Parks BW, Li D, Bui H, Mosier M, Wu Y, Huertas-Vazquez A, Hazen SW, Gundersen TE, Mehrabian M, Tang W, Hevener AL, Drevon CA, Lusis A. Genetic, dietary, and sex-specific regulation of hepatic ceramides and relationship between hepatic ceramides and insulin resistance. J Lipid Res. 2018 May 08. PMID: 29739864.
      View in: PubMed
    8. Seldin MM, Koplev S, Rajbhandari P, Vergnes L, Rosenberg GM, Meng Y, Pan C, Phuong TMN, Gharakhanian R, Che N, Mäkinen S, Shih DM, Civelek M, Parks BW, Kim ED, Norheim F, Chella Krishnan K, Hasin-Brumshtein Y, Mehrabian M, Laakso M, Drevon CA, Koistinen HA, Tontonoz P, Reue K, Cantor RM, Björkegren JLM, Lusis A. A Strategy for Discovery of Endocrine Interactions with Application to Whole-Body Metabolism. Cell Metab. 2018 May 01; 27(5):1138-1155.e6. PMID: 29719227.
      View in: PubMed
    9. Yu J, Seldin MM, Fu K, Li S, Lam L, Wang P, Wang Y, Huang D, Nguyen TL, Wei B, Kulkarni RP, Di Carlo D, Teitell M, Pellegrini M, Lusis A, Deb A. Topological Arrangement of Cardiac Fibroblasts Regulates Cellular Plasticity. Circ Res. 2018 Apr 24. PMID: 29691232.
      View in: PubMed
    10. Pan DZ, Garske KM, Alvarez M, Bhagat YV, Boocock J, Nikkola E, Miao Z, Raulerson CK, Cantor RM, Civelek M, Glastonbury CA, Small KS, Boehnke M, Lusis A, Sinsheimer JS, Mohlke KL, Laakso M, Pajukanta P, Ko A. Integration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from GWAS. Nat Commun. 2018 Apr 17; 9(1):1512. PMID: 29666371.
      View in: PubMed
    11. Hiyari S, Green E, Pan C, Lari S, Davar M, Davis R, Camargo PM, Tetradis S, Lusis A, Pirih FQ. Genome-Wide Association Study Identifies Cxcl Family Members as Partial Mediators of LPS-induced Periodontitis. J Bone Miner Res. 2018 Apr 10. PMID: 29637625.
      View in: PubMed
    12. Small KS, Todorcevic M, Civelek M, El-Sayed Moustafa JS, Wang X, Simon MM, Fernandez-Tajes J, Mahajan A, Horikoshi M, Hugill A, Glastonbury CA, Quaye L, Neville MJ, Sethi S, Yon M, Pan C, Che N, Viñuela A, Tsai PC, Nag A, Buil A, Thorleifsson G, Raghavan A, Ding Q, Morris AP, Bell JT, Thorsteinsdottir U, Stefansson K, Laakso M, Dahlman I, Arner P, Gloyn AL, Musunuru K, Lusis A, Cox RD, Karpe F, McCarthy MI. Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition. Nat Genet. 2018 Apr; 50(4):572-580. PMID: 29632379.
      View in: PubMed
    13. Santolini M, Romay MC, Yukhtman CL, Rau CD, Ren S, Saucerman JJ, Wang JJ, Weiss JN, Wang Y, Lusis A, Karma A. A personalized, multiomics approach identifies genes involved in cardiac hypertrophy and heart failure. NPJ Syst Biol Appl. 2018; 4:12. PMID: 29507758.
      View in: PubMed
    14. Sallam T, Jones M, Thomas BJ, Wu X, Gilliland T, Qian K, Eskin A, Casero D, Zhang Z, Sandhu J, Salisbury D, Rajbhandari P, Civelek M, Hong C, Ito A, Liu X, Daniel B, Lusis A, Whitelegge J, Nagy L, Castrillo A, Smale S, Tontonoz P. Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA. Nat Med. 2018 Mar; 24(3):304-312. PMID: 29431742.
      View in: PubMed
    15. Chella Krishnan K, Kurt Z, Barrere-Cain R, Sabir S, Das A, Floyd R, Vergnes L, Zhao Y, Che N, Charugundla S, Qi H, Zhou Z, Meng Y, Pan C, Seldin MM, Norheim F, Hui S, Reue K, Lusis A, Yang X. Integration of Multi-omics Data from Mouse Diversity Panel Highlights Mitochondrial Dysfunction in Non-alcoholic Fatty Liver Disease. Cell Syst. 2018 Jan 24; 6(1):103-115.e7. PMID: 29361464.
      View in: PubMed
    16. Barrington WT, Salvador AC, Hartiala JA, De Caterina R, Kohlmeier M, Martinez JA, Kreutzer CB, Heber D, Lusis A, Li Z, Allayee H. Proceedings of the 11th Congress of the International Society of Nutrigenetics and Nutrigenomics (ISNN 2017). J Nutrigenet Nutrigenomics. 2017; 10(5-6):155-162. PMID: 29339647.
      View in: PubMed
    17. Rajbhandari P, Thomas BJ, Feng AC, Hong C, Wang J, Vergnes L, Sallam T, Wang B, Sandhu J, Seldin MM, Lusis A, Fong LG, Katz M, Lee R, Young SG, Reue K, Smale ST, Tontonoz P. IL-10 Signaling Remodels Adipose Chromatin Architecture to Limit Thermogenesis and Energy Expenditure. Cell. 2018 Jan 11; 172(1-2):218-233.e17. PMID: 29249357.
      View in: PubMed
    18. Nakano H, Minami I, Braas D, Pappoe H, Wu X, Sagadevan A, Vergnes L, Fu K, Morselli M, Dunham C, Ding X, Stieg AZ, Gimzewski JK, Pellegrini M, Clark PM, Reue K, Lusis A, Ribalet B, Kurdistani SK, Christofk H, Nakatsuji N, Nakano A. Glucose inhibits cardiac muscle maturation through nucleotide biosynthesis. Elife. 2017 Dec 12; 6. PMID: 29231167.
      View in: PubMed
    19. Barrington WT, Lusis A. Atherosclerosis: Association between the gut microbiome and atherosclerosis. Nat Rev Cardiol. 2017 Dec; 14(12):699-700. PMID: 29099096.
      View in: PubMed
    20. Shu L, Chan KHK, Zhang G, Huan T, Kurt Z, Zhao Y, Codoni V, Trégouët DA, Yang J, Wilson JG, Luo X, Levy D, Lusis A, Liu S, Yang X. Shared genetic regulatory networks for cardiovascular disease and type 2 diabetes in multiple populations of diverse ethnicities in the United States. PLoS Genet. 2017 Sep; 13(9):e1007040. PMID: 28957322.
      View in: PubMed
    21. Cannon ME, Duan Q, Wu Y, Zeynalzadeh M, Xu Z, Kangas AJ, Soininen P, Ala-Korpela M, Civelek M, Lusis A, Kuusisto J, Collins FS, Boehnke M, Tang H, Laakso M, Li Y, Mohlke KL. Trans-ancestry Fine Mapping and Molecular Assays Identify Regulatory Variants at the ANGPTL8 HDL-C GWAS Locus. G3 (Bethesda). 2017 Sep 07; 7(9):3217-3227. PMID: 28754724.
      View in: PubMed
    22. McLachlan S, Page KE, Lee SM, Loguinov A, Valore E, Hui ST, Jung G, Zhou J, Lusis A, Fuqua B, Ganz T, Nemeth E, Vulpe CD. Hamp1 mRNA and plasma hepcidin levels are influenced by sex and strain but do not predict tissue iron levels in inbred mice. Am J Physiol Gastrointest Liver Physiol. 2017 Nov 01; 313(5):G511-G523. PMID: 28798083.
      View in: PubMed
    23. Kim S, Yang L, Kim S, Lee RG, Graham MJ, Berliner JA, Lusis A, Cai L, Temel RE, Rateri DL, Lee S. Targeting hepatic heparin-binding EGF-like growth factor (HB-EGF) induces anti-hyperlipidemia leading to reduction of angiotensin II-induced aneurysm development. PLoS One. 2017; 12(8):e0182566. PMID: 28792970.
      View in: PubMed
    24. Patterson M, Barske L, Van Handel B, Rau CD, Gan P, Sharma A, Parikh S, Denholtz M, Huang Y, Yamaguchi Y, Shen H, Allayee H, Crump JG, Force TI, Lien CL, Makita T, Lusis A, Kumar SR, Sucov HM. Frequency of mononuclear diploid cardiomyocytes underlies natural variation in heart regeneration. Nat Genet. 2017 Sep; 49(9):1346-1353. PMID: 28783163.
      View in: PubMed
    25. Buscher K, Ehinger E, Gupta P, Pramod AB, Wolf D, Tweet G, Pan C, Mills CD, Lusis A, Ley K. Natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival. Nat Commun. 2017 Jul 24; 8:16041. PMID: 28737175.
      View in: PubMed
    26. Daugherty A, Tall AR, Daemen MJAP, Falk E, Fisher EA, García-Cardeña G, Lusis A, Owens AP, Rosenfeld ME, Virmani R. Recommendation on Design, Execution, and Reporting of Animal Atherosclerosis Studies: A Scientific Statement From the American Heart Association. Circ Res. 2017 Sep 01; 121(6):e53-e79. PMID: 28729353.
      View in: PubMed
    27. Daugherty A, Tall AR, Daemen MJAP, Falk E, Fisher EA, García-Cardeña G, Lusis A, Owens AP, Rosenfeld ME, Virmani R. Recommendation on Design, Execution, and Reporting of Animal Atherosclerosis Studies: A Scientific Statement From the American Heart Association. Arterioscler Thromb Vasc Biol. 2017 09; 37(9):e131-e157. PMID: 28729366.
      View in: PubMed
    28. Schugar RC, Shih DM, Warrier M, Helsley RN, Burrows A, Ferguson D, Brown AL, Gromovsky AD, Heine M, Chatterjee A, Li L, Li XS, Wang Z, Willard B, Meng Y, Kim H, Che N, Pan C, Lee RG, Crooke RM, Graham MJ, Morton RE, Langefeld CD, Das SK, Rudel LL, Zein N, McCullough AJ, Dasarathy S, Tang WHW, Erokwu BO, Flask CA, Laakso M, Civelek M, Naga Prasad SV, Heeren J, Lusis A, Hazen SL, Brown JM. The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue. Cell Rep. 2017 07 05; 20(1):279. PMID: 28683320.
      View in: PubMed
    29. Schugar RC, Shih DM, Warrier M, Helsley RN, Burrows A, Ferguson D, Brown AL, Gromovsky AD, Heine M, Chatterjee A, Li L, Li XS, Wang Z, Willard B, Meng Y, Kim H, Che N, Pan C, Lee RG, Crooke RM, Graham MJ, Morton RE, Langefeld CD, Das SK, Rudel LL, Zein N, McCullough AJ, Dasarathy S, Tang WHW, Erokwu BO, Flask CA, Laakso M, Civelek M, Naga Prasad SV, Heeren J, Lusis A, Hazen SL, Brown JM. The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue. Cell Rep. 2017 06 20; 19(12):2451-2461. PMID: 28636934.
      View in: PubMed
    30. Mukherjee P, Hough G, Chattopadhyay A, Navab M, Fogelman HR, Meriwether D, Williams K, Bensinger S, Moller T, Faull KF, Lusis A, Iruela-Arispe ML, Bostrom KI, Tontonoz P, Reddy ST, Fogelman AM. Transgenic tomatoes expressing the 6F peptide and ezetimibe prevent diet-induced increases of IFN-ß and cholesterol 25-hydroxylase in jejunum. J Lipid Res. 2017 Aug; 58(8):1636-1647. PMID: 28592401.
      View in: PubMed
    31. Kessler T, Wobst J, Wolf B, Eckhold J, Vilne B, Hollstein R, von Ameln S, Dang TA, Sager HB, Moritz Rumpf P, Aherrahrou R, Kastrati A, Björkegren JLM, Erdmann J, Lusis A, Civelek M, Kaiser FJ, Schunkert H. Functional Characterization of the GUCY1A3 Coronary Artery Disease Risk Locus. Circulation. 2017 Aug 01; 136(5):476-489. PMID: 28487391.
      View in: PubMed
    32. Hasin Y, Seldin M, Lusis A. Multi-omics approaches to disease. Genome Biol. 2017 05 05; 18(1):83. PMID: 28476144.
      View in: PubMed
    33. Org E, Blum Y, Kasela S, Mehrabian M, Kuusisto J, Kangas AJ, Soininen P, Wang Z, Ala-Korpela M, Hazen SL, Laakso M, Lusis A. Relationships between gut microbiota, plasma metabolites, and metabolic syndrome traits in the METSIM cohort. Genome Biol. 2017 04 13; 18(1):70. PMID: 28407784.
      View in: PubMed
    34. Civelek M, Wu Y, Pan C, Raulerson CK, Ko A, He A, Tilford C, Saleem NK, Stancáková A, Scott LJ, Fuchsberger C, Stringham HM, Jackson AU, Narisu N, Chines PS, Small KS, Kuusisto J, Parks BW, Pajukanta P, Kirchgessner T, Collins FS, Gargalovic PS, Boehnke M, Laakso M, Mohlke KL, Lusis A. Genetic Regulation of Adipose Gene Expression and Cardio-Metabolic Traits. Am J Hum Genet. 2017 Mar 02; 100(3):428-443. PMID: 28257690.
      View in: PubMed
    35. Seldin MM, Kim ED, Romay MC, Li S, Rau CD, Wang JJ, Krishnan KC, Wang Y, Deb A, Lusis A. A systems genetics approach identifies Trp53inp2 as a link between cardiomyocyte glucose utilization and hypertrophic response. Am J Physiol Heart Circ Physiol. 2017 Apr 01; 312(4):H728-H741. PMID: 28235788.
      View in: PubMed
    36. Baliga NS, Björkegren JL, Boeke JD, Boutros M, Crawford NP, Dudley AM, Farber CR, Jones A, Levey AI, Lusis A, Mak HC, Nadeau JH, Noyes MB, Petretto E, Seyfried NT, Steinmetz LM, Vonesch SC. The State of Systems Genetics in 2017. Cell Syst. 2017 Jan 25; 4(1):7-15. PMID: 28125793.
      View in: PubMed
    37. Laakso M, Kuusisto J, Stancáková A, Kuulasmaa T, Pajukanta P, Lusis A, Collins FS, Mohlke KL, Boehnke M. The Metabolic Syndrome in Men study: a resource for studies of metabolic and cardiovascular diseases. J Lipid Res. 2017 Mar; 58(3):481-493. PMID: 28119442.
      View in: PubMed
    38. Link JC, Hasin-Brumshtein Y, Cantor RM, Chen X, Arnold AP, Lusis A, Reue K. Diet, gonadal sex, and sex chromosome complement influence white adipose tissue miRNA expression. BMC Genomics. 2017 01 17; 18(1):89. PMID: 28095800.
      View in: PubMed
    39. Rau CD, Civelek M, Pan C, Lusis A. A Suite of Tools for Biologists That Improve Accessibility and Visualization of Large Systems Genetics Datasets: Applications to the Hybrid Mouse Diversity Panel. Methods Mol Biol. 2017; 1488:153-188. PMID: 27933524.
      View in: PubMed
    40. von Scheidt M, Zhao Y, Kurt Z, Pan C, Zeng L, Yang X, Schunkert H, Lusis A. Applications and Limitations of Mouse Models for Understanding Human Atherosclerosis. Cell Metab. 2017 Feb 07; 25(2):248-261. PMID: 27916529.
      View in: PubMed
    41. Rau CD, Romay MC, Tuteryan M, Wang JJ, Santolini M, Ren S, Karma A, Weiss JN, Wang Y, Lusis A. Systems Genetics Approach Identifies Gene Pathways and Adamts2 as Drivers of Isoproterenol-Induced Cardiac Hypertrophy and Cardiomyopathy in Mice. Cell Syst. 2017 Jan 25; 4(1):121-128.e4. PMID: 27866946.
      View in: PubMed
    42. Pillai ICL, Li S, Romay M, Lam L, Lu Y, Huang J, Dillard N, Zemanova M, Rubbi L, Wang Y, Lee J, Xia M, Liang O, Xie YH, Pellegrini M, Lusis A, Deb A. Cardiac Fibroblasts Adopt Osteogenic Fates and Can Be Targeted to Attenuate Pathological Heart Calcification. Cell Stem Cell. 2017 02 02; 20(2):218-232.e5. PMID: 27867037.
      View in: PubMed
    43. Shu L, Zhao Y, Kurt Z, Byars SG, Tukiainen T, Kettunen J, Orozco LD, Pellegrini M, Lusis A, Ripatti S, Zhang B, Inouye M, Mäkinen VP, Yang X. Mergeomics: multidimensional data integration to identify pathogenic perturbations to biological systems. BMC Genomics. 2016 11 04; 17(1):874. PMID: 27814671.
      View in: PubMed
    44. Norheim F, Hui ST, Kulahcioglu E, Mehrabian M, Cantor RM, Pan C, Parks BW, Lusis A. Genetic and hormonal control of hepatic steatosis in female and male mice. J Lipid Res. 2017 Jan; 58(1):178-187. PMID: 27811231.
      View in: PubMed
    45. Joo JW, Kang EY, Org E, Furlotte N, Parks B, Hormozdiari F, Lusis A, Eskin E. Efficient and Accurate Multiple-Phenotype Regression Method for High Dimensional Data Considering Population Structure. Genetics. 2016 Dec; 204(4):1379-1390. PMID: 27770036.
      View in: PubMed
    46. Codoni V, Blum Y, Civelek M, Proust C, Franzén O, Björkegren JL, Le Goff W, Cambien F, Lusis A, Trégouët DA. Preservation Analysis of Macrophage Gene Coexpression Between Human and Mouse Identifies PARK2 as a Genetically Controlled Master Regulator of Oxidative Phosphorylation in Humans. G3 (Bethesda). 2016 10 13; 6(10):3361-3371. PMID: 27558669.
      View in: PubMed
    47. Lavinsky J, Ge M, Crow AL, Pan C, Wang J, Salehi P, Myint A, Eskin E, Allayee H, Lusis A, Friedman RA. The Genetic Architecture of Noise-Induced Hearing Loss: Evidence for a Gene-by-Environment Interaction. G3 (Bethesda). 2016 10 13; 6(10):3219-3228. PMID: 27520957.
      View in: PubMed
    48. Kang EY, Martin LJ, Mangul S, Isvilanonda W, Zou J, Ben-David E, Han B, Lusis A, Shifman S, Eskin E. Discovering Single Nucleotide Polymorphisms Regulating Human Gene Expression Using Allele Specific Expression from RNA-seq Data. Genetics. 2016 11; 204(3):1057-1064. PMID: 27765809.
      View in: PubMed
    49. Touat-Hamici Z, Weidmann H, Blum Y, Proust C, Durand H, Iannacci F, Codoni V, Gaignard P, Thérond P, Civelek M, Karabina SA, Lusis A, Cambien F, Ninio E. Role of lipid phosphate phosphatase 3 in human aortic endothelial cell function. Cardiovasc Res. 2016 Dec; 112(3):702-713. PMID: 27694435.
      View in: PubMed
    50. Wågsäter D, Vorkapic E, van Stijn CM, Kim J, Lusis A, Eriksson P, Tangirala RK. Elevated Adiponectin Levels Suppress Perivascular and Aortic Inflammation and Prevent AngII-induced Advanced Abdominal Aortic Aneurysms. Sci Rep. 2016 Sep 23; 6:31414. PMID: 27659201.
      View in: PubMed
    51. Hasin-Brumshtein Y, Khan AH, Hormozdiari F, Pan C, Parks BW, Petyuk VA, Piehowski PD, Brümmer A, Pellegrini M, Xiao X, Eskin E, Smith RD, Lusis A, Smith DJ. Hypothalamic transcriptomes of 99 mouse strains reveal trans eQTL hotspots, splicing QTLs and novel non-coding genes. Elife. 2016 09 13; 5. PMID: 27623010.
      View in: PubMed
    52. Salehi P, Myint A, Kim YJ, Ge MX, Lavinsky J, Ho MK, Crow AL, Cruz C, Monges-Hernadez M, Wang J, Hartiala J, Zhang LI, Allayee H, Lusis A, Ohyama T, Friedman RA. Genome-Wide Association Analysis Identifies Dcc as an Essential Factor in the Innervation of the Peripheral Vestibular System in Inbred Mice. J Assoc Res Otolaryngol. 2016 Oct; 17(5):417-31. PMID: 27539716; PMCID: PMC5023540 [Available on 10/01/17].
    53. Kojima Y, Volkmer JP, McKenna K, Civelek M, Lusis A, Miller CL, Direnzo D, Nanda V, Ye J, Connolly AJ, Schadt EE, Quertermous T, Betancur P, Maegdefessel L, Matic LP, Hedin U, Weissman IL, Leeper NJ. CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis. Nature. 2016 08 04; 536(7614):86-90. PMID: 27437576.
      View in: PubMed
    54. Du J, Leung A, Trac C, Lee M, Parks BW, Lusis A, Natarajan R, Schones DE. Chromatin variation associated with liver metabolism is mediated by transposable elements. Epigenetics Chromatin. 2016; 9:28. PMID: 27398095; PMCID: PMC4939004.
    55. Wang JJ, Rau C, Avetisyan R, Ren S, Romay MC, Stolin G, Gong KW, Wang Y, Lusis A. Genetic Dissection of Cardiac Remodeling in an Isoproterenol-Induced Heart Failure Mouse Model. PLoS Genet. 2016 07; 12(7):e1006038. PMID: 27385019; PMCID: PMC4934852.
    56. Org E, Mehrabian M, Parks BW, Shipkova P, Liu X, Drake TA, Lusis A. Sex differences and hormonal effects on gut microbiota composition in mice. Gut Microbes. 2016 07 03; 7(4):313-322. PMID: 27355107.
      View in: PubMed
    57. Karbassi E, Monte E, Chapski DJ, Lopez R, Rosa Garrido M, Kim J, Wisniewski N, Rau CD, Wang JJ, Weiss JN, Wang Y, Lusis A, Vondriska TM. Relationship of disease-associated gene expression to cardiac phenotype is buffered by genetic diversity and chromatin regulation. Physiol Genomics. 2016 08 01; 48(8):601-15. PMID: 27287924.
      View in: PubMed
    58. Hormozdiari F, Kang EY, Bilow M, Ben-David E, Vulpe C, McLachlan S, Lusis A, Han B, Eskin E. Imputing Phenotypes for Genome-wide Association Studies. Am J Hum Genet. 2016 Jul 07; 99(1):89-103. PMID: 27292110; PMCID: PMC5005435 [Available on 01/07/17].
    59. Monte E, Rosa-Garrido M, Karbassi E, Chen H, Lopez R, Rau CD, Wang J, Nelson SF, Wu Y, Stefani E, Lusis A, Wang Y, Kurdistani SK, Franklin S, Vondriska TM. Reciprocal Regulation of the Cardiac Epigenome by Chromatin Structural Proteins Hmgb and Ctcf: IMPLICATIONS FOR TRANSCRIPTIONAL REGULATION. J Biol Chem. 2016 07 22; 291(30):15428-46. PMID: 27226577; PMCID: PMC4957031 [Available on 07/22/17].
    60. Lusis A, Seldin MM, Allayee H, Bennett BJ, Civelek M, Davis RC, Eskin E, Farber CR, Hui S, Mehrabian M, Norheim F, Pan C, Parks B, Rau CD, Smith DJ, Vallim T, Wang Y, Wang J. The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits. J Lipid Res. 2016 06; 57(6):925-42. PMID: 27099397; PMCID: PMC4878195 [Available on 06/01/17].
    61. Ribas V, Drew BG, Zhou Z, Phun J, Kalajian NY, Soleymani T, Daraei P, Widjaja K, Wanagat J, de Aguiar Vallim TQ, Fluitt AH, Bensinger S, Le T, Radu C, Whitelegge JP, Beaven SW, Tontonoz P, Lusis A, Parks BW, Vergnes L, Reue K, Singh H, Bopassa JC, Toro L, Stefani E, Watt MJ, Schenk S, Akerstrom T, Kelly M, Pedersen BK, Hewitt SC, Korach KS, Hevener AL. Skeletal muscle action of estrogen receptor a is critical for the maintenance of mitochondrial function and metabolic homeostasis in females. Sci Transl Med. 2016 Apr 13; 8(334):334ra54. PMID: 27075628.
      View in: PubMed
    62. Zhu W, Gregory JC, Org E, Buffa JA, Gupta N, Wang Z, Li L, Fu X, Wu Y, Mehrabian M, Sartor RB, McIntyre TM, Silverstein RL, Tang WHW, DiDonato JA, Brown JM, Lusis A, Hazen SL. Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk. Cell. 2016 Mar 24; 165(1):111-124. PMID: 26972052; PMCID: PMC4862743 [Available on 03/24/17].
    63. Chattopadhyay A, Navab M, Hough G, Grijalva V, Mukherjee P, Fogelman HR, Hwang LH, Faull KF, Lusis A, Reddy ST, Fogelman AM. Tg6F ameliorates the increase in oxidized phospholipids in the jejunum of mice fed unsaturated LysoPC or WD. J Lipid Res. 2016 05; 57(5):832-47. PMID: 26965826; PMCID: PMC4847630 [Available on 05/01/17].
    64. Talukdar HA, Foroughi Asl H, Jain RK, Ermel R, Ruusalepp A, Franzén O, Kidd BA, Readhead B, Giannarelli C, Kovacic JC, Ivert T, Dudley JT, Civelek M, Lusis A, Schadt EE, Skogsberg J, Michoel T, Björkegren JL. Cross-Tissue Regulatory Gene Networks in Coronary Artery Disease. Cell Syst. 2016 Mar 23; 2(3):196-208. PMID: 27135365; PMCID: PMC4855300.
    65. Bennett BJ, Davis RC, Civelek M, Orozco L, Wu J, Qi H, Pan C, Sevag Packard RR, Eskin E, Yan M, Kirchgessner T, Wang Z, Li X, Gregory JC, Hazen SL, Gargalovic PS, Lusis A. Correction: Genetic Architecture of Atherosclerosis in Mice: A Systems Genetics Analysis of Common Inbred Strains. PLoS Genet. 2016 Mar; 12(3):e1005913. PMID: 26934746; PMCID: PMC4775237.
    66. Seldin MM, Meng Y, Qi H, Zhu W, Wang Z, Hazen SL, Lusis A, Shih DM. Trimethylamine N-Oxide Promotes Vascular Inflammation Through Signaling of Mitogen-Activated Protein Kinase and Nuclear Factor-?B. J Am Heart Assoc. 2016 Feb 22; 5(2). PMID: 26903003; PMCID: PMC4802459.
    67. Gusev A, Ko A, Shi H, Bhatia G, Chung W, Penninx BW, Jansen R, de Geus EJ, Boomsma DI, Wright FA, Sullivan PF, Nikkola E, Alvarez M, Civelek M, Lusis A, Lehtimäki T, Raitoharju E, Kähönen M, Seppälä I, Raitakari OT, Kuusisto J, Laakso M, Price AL, Pajukanta P, Pasaniuc B. Integrative approaches for large-scale transcriptome-wide association studies. Nat Genet. 2016 Mar; 48(3):245-52. PMID: 26854917; PMCID: PMC4767558 [Available on 03/01/17].
    68. Chen H, Orozco LD, Wang J, Rau CD, Rubbi L, Ren S, Wang Y, Pellegrini M, Lusis A, Vondriska TM. DNA Methylation Indicates Susceptibility to Isoproterenol-Induced Cardiac Pathology and Is Associated With Chromatin States. Circ Res. 2016 Mar 04; 118(5):786-97. PMID: 26838786; PMCID: PMC4779427 [Available on 03/04/17].
    69. Bennett BJ, Davis RC, Civelek M, Orozco L, Wu J, Qi H, Pan C, Packard RR, Eskin E, Yan M, Kirchgessner T, Wang Z, Li X, Gregory JC, Hazen SL, Gargalovic PS, Lusis A. Genetic Architecture of Atherosclerosis in Mice: A Systems Genetics Analysis of Common Inbred Strains. PLoS Genet. 2015 Dec; 11(12):e1005711. PMID: 26694027; PMCID: PMC4687930.
    70. Wang Z, Roberts AB, Buffa JA, Levison BS, Zhu W, Org E, Gu X, Huang Y, Zamanian-Daryoush M, Culley MK, DiDonato AJ, Fu X, Hazen JE, Krajcik D, DiDonato JA, Lusis A, Hazen SL. Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis. Cell. 2015 Dec 17; 163(7):1585-95. PMID: 26687352; PMCID: PMC4871610 [Available on 12/17/16].
    71. Pamir N, Hutchins P, Ronsein G, Vaisar T, Reardon CA, Getz GS, Lusis A, Heinecke JW. Proteomic analysis of HDL from inbred mouse strains implicates APOE associated with HDL in reduced cholesterol efflux capacity via the ABCA1 pathway. J Lipid Res. 2016 Feb; 57(2):246-57. PMID: 26673204; PMCID: PMC4727420.
    72. Roman TS, Marvelle AF, Fogarty MP, Vadlamudi S, Gonzalez AJ, Buchkovich ML, Huyghe JR, Fuchsberger C, Jackson AU, Wu Y, Civelek M, Lusis A, Gaulton KJ, Sethupathy P, Kangas AJ, Soininen P, Ala-Korpela M, Kuusisto J, Collins FS, Laakso M, Boehnke M, Mohlke KL. Multiple Hepatic Regulatory Variants at the GALNT2 GWAS Locus Associated with High-Density Lipoprotein Cholesterol. Am J Hum Genet. 2015 Dec 03; 97(6):801-15. PMID: 26637976; PMCID: PMC4678431.
    73. Briot A, Civelek M, Seki A, Hoi K, Mack JJ, Lee SD, Kim J, Hong C, Yu J, Fishbein GA, Vakili L, Fogelman AM, Fishbein MC, Lusis A, Tontonoz P, Navab M, Berliner JA, Iruela-Arispe ML. Endothelial NOTCH1 is suppressed by circulating lipids and antagonizes inflammation during atherosclerosis. J Exp Med. 2015 Nov 16; 212(12):2147-63. PMID: 26552708; PMCID: PMC4647265.
    74. Cattin ME, Wang J, Weldrick JJ, Roeske CL, Mak E, Thorn SL, DaSilva JN, Wang Y, Lusis A, Burgon PG. Deletion of MLIP (muscle-enriched A-type lamin-interacting protein) leads to cardiac hyperactivation of Akt/mammalian target of rapamycin (mTOR) and impaired cardiac adaptation. J Biol Chem. 2015 Oct 30; 290(44):26699-714. PMID: 26359501; PMCID: PMC4646324 [Available on 10/30/16].
    75. Crow AL, Ohmen J, Wang J, Lavinsky J, Hartiala J, Li Q, Li X, Salehide P, Eskin E, Pan C, Lusis A, Allayee H, Friedman RA. The Genetic Architecture of Hearing Impairment in Mice: Evidence for Frequency-Specific Genetic Determinants. G3 (Bethesda). 2015 Sep 04; 5(11):2329-39. PMID: 26342000; PMCID: PMC4632053.
    76. Schrauwen I, Hasin-Brumshtein Y, Corneveaux JJ, Ohmen J, White C, Allen AN, Lusis A, Van Camp G, Huentelman MJ, Friedman RA. A comprehensive catalogue of the coding and non-coding transcripts of the human inner ear. Hear Res. 2016 Mar; 333:266-274. PMID: 26341477.
      View in: PubMed
    77. Brænne I, Civelek M, Vilne B, Di Narzo A, Johnson AD, Zhao Y, Reiz B, Codoni V, Webb TR, Foroughi Asl H, Hamby SE, Zeng L, Trégouët DA, Hao K, Topol EJ, Schadt EE, Yang X, Samani NJ, Björkegren JL, Erdmann J, Schunkert H, Lusis A. Prediction of Causal Candidate Genes in Coronary Artery Disease Loci. Arterioscler Thromb Vasc Biol. 2015 Oct; 35(10):2207-17. PMID: 26293461; PMCID: PMC4583353 [Available on 10/01/16].
    78. Org E, Parks BW, Joo JW, Emert B, Schwartzman W, Kang EY, Mehrabian M, Pan C, Knight R, Gunsalus R, Drake TA, Eskin E, Lusis A. Genetic and environmental control of host-gut microbiota interactions. Genome Res. 2015 Oct; 25(10):1558-69. PMID: 26260972; PMCID: PMC4579341.
    79. Rau CD, Parks B, Wang Y, Eskin E, Simecek P, Churchill GA, Lusis A. High-Density Genotypes of Inbred Mouse Strains: Improved Power and Precision of Association Mapping. G3 (Bethesda). 2015 Jul 28; 5(10):2021-6. PMID: 26224782; PMCID: PMC4592984.
    80. Nanda V, Gutman B, Bar E, Alghamdi S, Tetradis S, Lusis A, Eskin E, Moon W. Quantitative analysis of 3-dimensional facial soft tissue photographic images: technical methods and clinical application. Prog Orthod. 2015; 16:21. PMID: 26133934; PMCID: PMC4488234.
    81. Lusis A. Cardiovascular disease genes come together. Atherosclerosis. 2015 Oct; 242(2):630-1. PMID: 26152393.
      View in: PubMed
    82. Hui ST, Parks BW, Org E, Norheim F, Che N, Pan C, Castellani LW, Charugundla S, Dirks DL, Psychogios N, Neuhaus I, Gerszten RE, Kirchgessner T, Gargalovic PS, Lusis A. The genetic architecture of NAFLD among inbred strains of mice. Elife. 2015 Jun 12; 4:e05607. PMID: 26067236; PMCID: PMC4493743.
    83. Lavinsky J, Crow AL, Pan C, Wang J, Aaron KA, Ho MK, Li Q, Salehide P, Myint A, Monges-Hernadez M, Eskin E, Allayee H, Lusis A, Friedman RA. Correction: Genome-Wide Association Study Identifies Nox3 as a Critical Gene for Susceptibility to Noise-Induced Hearing Loss. PLoS Genet. 2015 Jun; 11(6):e1005293. PMID: 26068505; PMCID: PMC4465750.
    84. Zhou X, Crow AL, Hartiala J, Spindler TJ, Ghazalpour A, Barsky LW, Bennett BJ, Parks BW, Eskin E, Jain R, Epstein JA, Lusis A, Adams GB, Allayee H. The Genetic Landscape of Hematopoietic Stem Cell Frequency in Mice. Stem Cell Reports. 2015 Jul 14; 5(1):125-38. PMID: 26050929; PMCID: PMC4618249.
    85. Org E, Mehrabian M, Lusis A. Unraveling the environmental and genetic interactions in atherosclerosis: Central role of the gut microbiota. Atherosclerosis. 2015 Aug; 241(2):387-99. PMID: 26071662; PMCID: PMC4510029.
    86. Orozco LD, Morselli M, Rubbi L, Guo W, Go J, Shi H, Lopez D, Furlotte NA, Bennett BJ, Farber CR, Ghazalpour A, Zhang MQ, Bahous R, Rozen R, Lusis A, Pellegrini M. Epigenome-wide association of liver methylation patterns and complex metabolic traits in mice. Cell Metab. 2015 Jun 02; 21(6):905-17. PMID: 26039453; PMCID: PMC4454894.
    87. Wu C, Huang RT, Kuo CH, Kumar S, Kim CW, Lin YC, Chen YJ, Birukova A, Birukov KG, Dulin NO, Civelek M, Lusis A, Loyer X, Tedgui A, Dai G, Jo H, Fang Y. Mechanosensitive PPAP2B Regulates Endothelial Responses to Atherorelevant Hemodynamic Forces. Circ Res. 2015 Jul 31; 117(4):e41-e53. PMID: 26034042.
      View in: PubMed
    88. Rau CD, Lusis A, Wang Y. Genetics of common forms of heart failure: challenges and potential solutions. Curr Opin Cardiol. 2015 May; 30(3):222-7. PMID: 25768955; PMCID: PMC4406340.
    89. Kenagy RD, Civelek M, Kikuchi S, Chen L, Grieff A, Sobel M, Lusis A, Clowes AW. Scavenger receptor class A member 5 (SCARA5) and suprabasin (SBSN) are hub genes of coexpression network modules associated with peripheral vein graft patency. J Vasc Surg. 2016 07; 64(1):202-209.e6. PMID: 25935274.
      View in: PubMed
    90. Fox CS, Hall JL, Arnett DK, Ashley EA, Delles C, Engler MB, Freeman MW, Johnson JA, Lanfear DE, Liggett SB, Lusis A, Loscalzo J, MacRae CA, Musunuru K, Newby LK, O'Donnell CJ, Rich SS, Terzic A. Future translational applications from the contemporary genomics era: a scientific statement from the American Heart Association. Circulation. 2015 May 12; 131(19):1715-36. PMID: 25882488; PMCID: PMC4825323.
    91. Lavinsky J, Crow AL, Pan C, Wang J, Aaron KA, Ho MK, Li Q, Salehide P, Myint A, Monges-Hernadez M, Eskin E, Allayee H, Lusis A, Friedman RA. Genome-wide association study identifies nox3 as a critical gene for susceptibility to noise-induced hearing loss. PLoS Genet. 2015 Apr; 11(4):e1005094. PMID: 25880434; PMCID: PMC4399881.
    92. Blazquez-Medela AM, Guihard PJ, Yao J, Jumabay M, Lusis A, Boström KI, Yao Y. ABCC6 deficiency is associated with activation of BMP signaling in liver and kidney. FEBS Open Bio. 2015; 5:257-63. PMID: 25893161; PMCID: PMC4398664.
    93. Roux PF, Boitard S, Blum Y, Parks B, Montagner A, Mouisel E, Djari A, Esquerré D, Désert C, Boutin M, Leroux S, Lecerf F, Le Bihan-Duval E, Klopp C, Servin B, Pitel F, Duclos MJ, Guillou H, Lusis A, Demeure O, Lagarrigue S. Combined QTL and selective sweep mappings with coding SNP annotation and cis-eQTL analysis revealed PARK2 and JAG2 as new candidate genes for adiposity regulation. G3 (Bethesda). 2015 Feb 03; 5(4):517-29. PMID: 25653314; PMCID: PMC4390568.
    94. Parks BW, Sallam T, Mehrabian M, Psychogios N, Hui ST, Norheim F, Castellani LW, Rau CD, Pan C, Phun J, Zhou Z, Yang WP, Neuhaus I, Gargalovic PS, Kirchgessner TG, Graham M, Lee R, Tontonoz P, Gerszten RE, Hevener AL, Lusis A. Genetic architecture of insulin resistance in the mouse. Cell Metab. 2015 Feb 03; 21(2):334-347. PMID: 25651185.
      View in: PubMed
    95. Warrier M, Shih DM, Burrows AC, Ferguson D, Gromovsky AD, Brown AL, Marshall S, McDaniel A, Schugar RC, Wang Z, Sacks J, Rong X, Vallim TA, Chou J, Ivanova PT, Myers DS, Brown HA, Lee RG, Crooke RM, Graham MJ, Liu X, Parini P, Tontonoz P, Lusis A, Hazen SL, Temel RE, Brown JM. The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance. Cell Rep. 2015 Jan 14. PMID: 25600868.
      View in: PubMed
    96. Gregory JC, Buffa JA, Org E, Wang Z, Levison BS, Zhu W, Wagner MA, Bennett BJ, Li L, DiDonato JA, Lusis A, Hazen SL. Transmission of atherosclerosis susceptibility with gut microbial transplantation. J Biol Chem. 2015 Feb 27; 290(9):5647-60. PMID: 25550161; PMCID: PMC4342477.
    97. Rau CD, Wang J, Avetisyan R, Romay MC, Martin L, Ren S, Wang Y, Lusis A. Mapping genetic contributions to cardiac pathology induced by Beta-adrenergic stimulation in mice. Circ Cardiovasc Genet. 2015 Feb; 8(1):40-9. PMID: 25480693; PMCID: PMC4334708.
    98. Shih DM, Yu JM, Vergnes L, Dali-Youcef N, Champion MD, Devarajan A, Zhang P, Castellani LW, Brindley DN, Jamey C, Auwerx J, Reddy ST, Ford DA, Reue K, Lusis A. PON3 knockout mice are susceptible to obesity, gallstone formation, and atherosclerosis. FASEB J. 2015 Apr; 29(4):1185-97. PMID: 25477283; PMCID: PMC4396607.
    99. Drew BG, Hamidi H, Zhou Z, Villanueva CJ, Krum SA, Calkin AC, Parks BW, Ribas V, Kalajian NY, Phun J, Daraei P, Christofk HR, Hewitt SC, Korach KS, Tontonoz P, Lusis A, Slamon DJ, Hurvitz SA, Hevener AL. Estrogen receptor (ER)a-regulated lipocalin 2 expression in adipose tissue links obesity with breast cancer progression. J Biol Chem. 2015 Feb 27; 290(9):5566-81. PMID: 25468909; PMCID: PMC4342471.
    100. van Stijn CM, Kim J, Lusis A, Barish GD, Tangirala RK. Macrophage polarization phenotype regulates adiponectin receptor expression and adiponectin anti-inflammatory response. FASEB J. 2015 Feb; 29(2):636-49. PMID: 25392268; PMCID: PMC4314235.
    101. Shih DM, Wang Z, Lee R, Meng Y, Che N, Charugundla S, Qi H, Wu J, Pan C, Brown JM, Vallim T, Bennett BJ, Graham M, Hazen SL, Lusis A. Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis. J Lipid Res. 2015 Jan; 56(1):22-37. PMID: 25378658; PMCID: PMC4274068.
    102. Chan KH, Huang YT, Meng Q, Wu C, Reiner A, Sobel EM, Tinker L, Lusis A, Yang X, Liu S. Shared molecular pathways and gene networks for cardiovascular disease and type 2 diabetes mellitus in women across diverse ethnicities. Circ Cardiovasc Genet. 2014 Dec; 7(6):911-9. PMID: 25371518.
      View in: PubMed
    103. Koeth RA, Levison BS, Culley MK, Buffa JA, Wang Z, Gregory JC, Org E, Wu Y, Li L, Smith JD, Tang WHW, DiDonato JA, Lusis A, Hazen SL. ?-Butyrobetaine is a proatherogenic intermediate in gut microbial metabolism of L-carnitine to TMAO. Cell Metab. 2014 Nov 04; 20(5):799-812. PMID: 25440057.
      View in: PubMed
    104. Gordts PLSM, Foley EM, Lawrence R, Sinha R, Lameda-Diaz C, Deng L, Nock R, Glass CK, Erbilgin A, Lusis A, Witztum JL, Esko JD. Reducing macrophage proteoglycan sulfation increases atherosclerosis and obesity through enhanced type I interferon signaling. Cell Metab. 2014 Nov 04; 20(5):813-826. PMID: 25440058.
      View in: PubMed
    105. Wu X, Davis RC, McMillen TS, Schaeffer V, Zhou Z, Qi H, Mazandarani PN, Alialy R, Hudkins KL, Lusis A, LeBoeuf RC. Genetic modulation of diabetic nephropathy among mouse strains with Ins2 Akita mutation. Physiol Rep. 2014 Nov 01; 2(11). PMID: 25428948; PMCID: PMC4255814.
    106. Romay MC, Che N, Becker SN, Pouldar D, Hagopian R, Xiao X, Lusis A, Berliner JA, Civelek M. Regulation of NF-?B signaling by oxidized glycerophospholipid and IL-1ß induced miRs-21-3p and -27a-5p in human aortic endothelial cells. J Lipid Res. 2015 Jan; 56(1):38-50. PMID: 25327529; PMCID: PMC4274069.
    107. Civelek M, Lusis A. From hairballs to an understanding of transendothelial migration of monocytes in atherosclerosis. Arterioscler Thromb Vasc Biol. 2014 Sep; 34(9):1809-10. PMID: 25142882; PMCID: PMC4142522.
    108. Albright J, Quizon PM, Lusis A, Bennett BJ. Genetic network identifies novel pathways contributing to atherosclerosis susceptibility in the innominate artery. BMC Med Genomics. 2014 Aug 12; 7:51. PMID: 25115202; PMCID: PMC4142055.
    109. Bolnick DI, Snowberg LK, Hirsch PE, Lauber CL, Org E, Parks B, Lusis A, Knight R, Caporaso JG, Svanbäck R. Individual diet has sex-dependent effects on vertebrate gut microbiota. Nat Commun. 2014 Jul 29; 5:4500. PMID: 25072318; PMCID: PMC4279269.
    110. Mäkinen VP, Civelek M, Meng Q, Zhang B, Zhu J, Levian C, Huan T, Segrè AV, Ghosh S, Vivar J, Nikpay M, Stewart AF, Nelson CP, Willenborg C, Erdmann J, Blakenberg S, O'Donnell CJ, März W, Laaksonen R, Epstein SE, Kathiresan S, Shah SH, Hazen SL, Reilly MP, Lusis A, Samani NJ, Schunkert H, Quertermous T, McPherson R, Yang X, Assimes TL. Integrative genomics reveals novel molecular pathways and gene networks for coronary artery disease. PLoS Genet. 2014 Jul; 10(7):e1004502. PMID: 25033284; PMCID: PMC4102418.
    111. Leung A, Parks BW, Du J, Trac C, Setten R, Chen Y, Brown K, Lusis A, Natarajan R, Schones DE. Open chromatin profiling in mice livers reveals unique chromatin variations induced by high fat diet. J Biol Chem. 2014 Aug 22; 289(34):23557-67. PMID: 25006255; PMCID: PMC4156056.
    112. Calkin AC, Lee SD, Kim J, Van Stijn CM, Wu XH, Lusis A, Hong C, Tangirala RI, Tontonoz P. Transgenic expression of dominant-active IDOL in liver causes diet-induced hypercholesterolemia and atherosclerosis in mice. Circ Res. 2014 Aug 01; 115(4):442-9. PMID: 24935961; PMCID: PMC4119488.
    113. Hasin-Brumshtein Y, Hormozdiari F, Martin L, van Nas A, Eskin E, Lusis A, Drake TA. Allele-specific expression and eQTL analysis in mouse adipose tissue. BMC Genomics. 2014 Jun 13; 15:471. PMID: 24927774; PMCID: PMC4089026.
    114. Ghazalpour A, Bennett BJ, Shih D, Che N, Orozco L, Pan C, Hagopian R, He A, Kayne P, Yang WP, Kirchgessner T, Lusis A. Genetic regulation of mouse liver metabolite levels. Mol Syst Biol. 2014 May 23; 10:730. PMID: 24860088; PMCID: PMC4188043.
    115. Emert B, Hasin-Brumshtein Y, Springstead JR, Vakili L, Berliner JA, Lusis A. HDL inhibits the effects of oxidized phospholipids on endothelial cell gene expression via multiple mechanisms. J Lipid Res. 2014 Aug; 55(8):1678-92. PMID: 24859737; PMCID: PMC4109762.
    116. Orozco LD, Rubbi L, Martin LJ, Fang F, Hormozdiari F, Che N, Smith AD, Lusis A, Pellegrini M. Intergenerational genomic DNA methylation patterns in mouse hybrid strains. Genome Biol. 2014 Apr 30; 15(5):R68. PMID: 24887417; PMCID: PMC4076608.
    117. Hartiala J, Bennett BJ, Tang WH, Wang Z, Stewart AF, Roberts R, McPherson R, Lusis A, Hazen SL, Allayee H. Comparative genome-wide association studies in mice and humans for trimethylamine N-oxide, a proatherogenic metabolite of choline and L-carnitine. Arterioscler Thromb Vasc Biol. 2014 Jun; 34(6):1307-13. PMID: 24675659; PMCID: PMC4035110.
    118. Ohmen J, Kang EY, Li X, Joo JW, Hormozdiari F, Zheng QY, Davis RC, Lusis A, Eskin E, Friedman RA. Genome-wide association study for age-related hearing loss (AHL) in the mouse: a meta-analysis. J Assoc Res Otolaryngol. 2014 Jun; 15(3):335-52. PMID: 24570207; PMCID: PMC4010595.
    119. Okamoto R, Gery S, Gombart AF, Wang X, Castellani LW, Akagi T, Chen S, Arditi M, Ho Q, Lusis A, Li Q, Koeffler HP. Deficiency of CCAAT/enhancer binding protein-epsilon reduces atherosclerotic lesions in LDLR-/- mice. PLoS One. 2014; 9(1):e85341. PMID: 24489659; PMCID: PMC3904867.
    120. Kang EY, Han B, Furlotte N, Joo JW, Shih D, Davis RC, Lusis A, Eskin E. Meta-analysis identifies gene-by-environment interactions as demonstrated in a study of 4,965 mice. PLoS Genet. 2014 Jan; 10(1):e1004022. PMID: 24415945; PMCID: PMC3886926.
    121. Parks BW, Lusis A. Macrophage accumulation in atherosclerosis. N Engl J Med. 2013 Dec 12; 369(24):2352-3. PMID: 24328470; PMCID: PMC3934498.
    122. Maubaret CG, Salpea KD, Romanoski CE, Folkersen L, Cooper JA, Stephanou C, Li KW, Palmen J, Hamsten A, Neil A, Stephens JW, Lusis A, Eriksson P, Talmud PJ, Humphries SE. Association of TERC and OBFC1 haplotypes with mean leukocyte telomere length and risk for coronary heart disease. PLoS One. 2013; 8(12):e83122. PMID: 24349443; PMCID: PMC3861448.
    123. Kautz L, Gabayan V, Wang X, Wu J, Onwuzurike J, Jung G, Qiao B, Lusis A, Ganz T, Nemeth E. Testing the iron hypothesis in a mouse model of atherosclerosis. Cell Rep. 2013 Dec 12; 5(5):1436-42. PMID: 24316081; PMCID: PMC3880128.
    124. Civelek M, Lusis A. Systems genetics approaches to understand complex traits. Nat Rev Genet. 2014 Jan; 15(1):34-48. PMID: 24296534; PMCID: PMC3934510.
    125. Csaki LS, Dwyer JR, Li X, Nguyen MH, Dewald J, Brindley DN, Lusis A, Yoshinaga Y, de Jong P, Fong L, Young SG, Reue K. Lipin-1 and lipin-3 together determine adiposity in vivo. Mol Metab. 2014 Apr; 3(2):145-54. PMID: 24634820; PMCID: PMC3953701.
    126. Welch C, Lusis A. Genetics of common forms of heart disease: a long and winding road. Circ Res. 2013 Oct 12; 113(9):1035-6. PMID: 24115066; PMCID: PMC3934500.
    127. Navab M, Hough G, Buga GM, Su F, Wagner AC, Meriwether D, Chattopadhyay A, Gao F, Grijalva V, Danciger JS, Van Lenten BJ, Org E, Lusis A, Pan C, Anantharamaiah GM, Farias-Eisner R, Smyth SS, Reddy ST, Fogelman AM. Transgenic 6F tomatoes act on the small intestine to prevent systemic inflammation and dyslipidemia caused by Western diet and intestinally derived lysophosphatidic acid. J Lipid Res. 2013 Dec; 54(12):3403-18. PMID: 24085744; PMCID: PMC3826687.
    128. Lagarrigue S, Martin L, Hormozdiari F, Roux PF, Pan C, van Nas A, Demeure O, Cantor R, Ghazalpour A, Eskin E, Lusis A. Analysis of allele-specific expression in mouse liver by RNA-Seq: a comparison with Cis-eQTL identified using genetic linkage. Genetics. 2013 Nov; 195(3):1157-66. PMID: 24026101; PMCID: PMC3813844.
    129. Erbilgin A, Siemers N, Kayne P, Yang WP, Berliner J, Lusis A. Gene expression analyses of mouse aortic endothelium in response to atherogenic stimuli. Arterioscler Thromb Vasc Biol. 2013 Nov; 33(11):2509-17. PMID: 23990205; PMCID: PMC4105212.
    130. Lu G, Ota A, Ren S, Franklin S, Rau CD, Ping P, Lane TF, Zhou ZH, Reue K, Lusis A, Vondriska T, Wang Y. PPM1l encodes an inositol requiring-protein 1 (IRE1) specific phosphatase that regulates the functional outcome of the ER stress response. Mol Metab. 2013; 2(4):405-16. PMID: 24327956; PMCID: PMC3854994.
    131. Huang Y, Wu Z, Riwanto M, Gao S, Levison BS, Gu X, Fu X, Wagner MA, Besler C, Gerstenecker G, Zhang R, Li XM, DiDonato AJ, Gogonea V, Tang WH, Smith JD, Plow EF, Fox PL, Shih DM, Lusis A, Fisher EA, DiDonato JA, Landmesser U, Hazen SL. Myeloperoxidase, paraoxonase-1, and HDL form a functional ternary complex. J Clin Invest. 2013 Sep; 123(9):3815-28. PMID: 23908111; PMCID: PMC3754253.
    132. Shih DM, Shaposhnik Z, Meng Y, Rosales M, Wang X, Wu J, Ratiner B, Zadini F, Zadini G, Lusis A. Hyodeoxycholic acid improves HDL function and inhibits atherosclerotic lesion formation in LDLR-knockout mice. FASEB J. 2013 Sep; 27(9):3805-17. PMID: 23752203; PMCID: PMC3752541.
    133. van Nas A, Pan C, Ingram-Drake LA, Ghazalpour A, Drake TA, Sobel EM, Papp JC, Lusis A. The systems genetics resource: a web application to mine global data for complex disease traits. Front Genet. 2013; 4:84. PMID: 23730305; PMCID: PMC3657633.
    134. Erbilgin A, Civelek M, Romanoski CE, Pan C, Hagopian R, Berliner JA, Lusis A. Identification of CAD candidate genes in GWAS loci and their expression in vascular cells. J Lipid Res. 2013 Jul; 54(7):1894-905. PMID: 23667179; PMCID: PMC3679391.
    135. Martin LJ, Lau E, Singh H, Vergnes L, Tarling EJ, Mehrabian M, Mungrue I, Xiao S, Shih D, Castellani L, Ping P, Reue K, Stefani E, Drake TA, Bostrom K, Lusis A. Response to Pomozi et al's research commentary. Circ Res. 2013 May 24; 112(11):e152-3. PMID: 23625949; PMCID: PMC3999040.
    136. Koeth RA, Wang Z, Levison BS, Buffa JA, Org E, Sheehy BT, Britt EB, Fu X, Wu Y, Li L, Smith JD, DiDonato JA, Chen J, Li H, Wu GD, Lewis JD, Warrier M, Brown JM, Krauss RM, Tang WH, Bushman FD, Lusis A, Hazen SL. Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med. 2013 May; 19(5):576-85. PMID: 23563705; PMCID: PMC3650111.
    137. Civelek M, Hagopian R, Pan C, Che N, Yang WP, Kayne PS, Saleem NK, Cederberg H, Kuusisto J, Gargalovic PS, Kirchgessner TG, Laakso M, Lusis A. Genetic regulation of human adipose microRNA expression and its consequences for metabolic traits. Hum Mol Genet. 2013 Aug 01; 22(15):3023-37. PMID: 23562819; PMCID: PMC3699064.
    138. Mahendran Y, Vangipurapu J, Cederberg H, Stancáková A, Pihlajamäki J, Soininen P, Kangas AJ, Paananen J, Civelek M, Saleem NK, Pajukanta P, Lusis A, Bonnycastle LL, Morken MA, Collins FS, Mohlke KL, Boehnke M, Ala-Korpela M, Kuusisto J, Laakso M. Association of ketone body levels with hyperglycemia and type 2 diabetes in 9,398 Finnish men. Diabetes. 2013 Oct; 62(10):3618-26. PMID: 23557707; PMCID: PMC3781437.
    139. Weissglas-Volkov D, Aguilar-Salinas CA, Nikkola E, Deere KA, Cruz-Bautista I, Arellano-Campos O, Muñoz-Hernandez LL, Gomez-Munguia L, Ordoñez-Sánchez ML, Reddy PM, Lusis A, Matikainen N, Taskinen MR, Riba L, Cantor RM, Sinsheimer JS, Tusie-Luna T, Pajukanta P. Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci. J Med Genet. 2013 May; 50(5):298-308. PMID: 23505323; PMCID: PMC3917605.
    140. Rau CD, Wisniewski N, Orozco LD, Bennett B, Weiss J, Lusis A. Maximal information component analysis: a novel non-linear network analysis method. Front Genet. 2013; 4:28. PMID: 23487572; PMCID: PMC3594742.
    141. Davis RC, van Nas A, Bennett B, Orozco L, Pan C, Rau CD, Eskin E, Lusis A. Genome-wide association mapping of blood cell traits in mice. Mamm Genome. 2013 Apr; 24(3-4):105-18. PMID: 23417284; PMCID: PMC3933005.
    142. Lagarrigue S, Hormozdiari F, Martin LJ, Lecerf F, Hasin Y, Rau C, Hagopian R, Xiao Y, Yan J, Drake TA, Ghazalpour A, Eskin E, Lusis A. Limited RNA editing in exons of mouse liver and adipose. Genetics. 2013 Apr; 193(4):1107-15. PMID: 23410828; PMCID: PMC3606090.
    143. Parks BW, Nam E, Org E, Kostem E, Norheim F, Hui ST, Pan C, Civelek M, Rau CD, Bennett BJ, Mehrabian M, Ursell LK, He A, Castellani LW, Zinker B, Kirby M, Drake TA, Drevon CA, Knight R, Gargalovic P, Kirchgessner T, Eskin E, Lusis A. Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice. Cell Metab. 2013 Jan 08; 17(1):141-52. PMID: 23312289; PMCID: PMC3545283.
    144. Bennett BJ, de Aguiar Vallim TQ, Wang Z, Shih DM, Meng Y, Gregory J, Allayee H, Lee R, Graham M, Crooke R, Edwards PA, Hazen SL, Lusis A. Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation. Cell Metab. 2013 Jan 08; 17(1):49-60. PMID: 23312283; PMCID: PMC3771112.
    145. Marquart TJ, Wu J, Lusis A, Baldán Á. Anti-miR-33 therapy does not alter the progression of atherosclerosis in low-density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol. 2013 Mar; 33(3):455-8. PMID: 23288159; PMCID: PMC3587119.
    146. Calabrese G, Bennett BJ, Orozco L, Kang HM, Eskin E, Dombret C, De Backer O, Lusis A, Farber CR. Systems genetic analysis of osteoblast-lineage cells. PLoS Genet. 2012; 8(12):e1003150. PMID: 23300464; PMCID: PMC3531492.
    147. Halperin DS, Pan C, Lusis A, Tontonoz P. Vestigial-like 3 is an inhibitor of adipocyte differentiation. J Lipid Res. 2013 Feb; 54(2):473-81. PMID: 23152581; PMCID: PMC3541706.
    148. Orozco LD, Bennett BJ, Farber CR, Ghazalpour A, Pan C, Che N, Wen P, Qi HX, Mutukulu A, Siemers N, Neuhaus I, Yordanova R, Gargalovic P, Pellegrini M, Kirchgessner T, Lusis A. Unraveling inflammatory responses using systems genetics and gene-environment interactions in macrophages. Cell. 2012 Oct 26; 151(3):658-70. PMID: 23101632; PMCID: PMC3513387.
    149. Kim JB, Deluna A, Mungrue IN, Vu C, Pouldar D, Civelek M, Orozco L, Wu J, Wang X, Charugundla S, Castellani LW, Rusek M, Jakubowski H, Jakobowski H, Lusis A. Effect of 9p21.3 coronary artery disease locus neighboring genes on atherosclerosis in mice. Circulation. 2012 Oct 09; 126(15):1896-906. PMID: 22952318; PMCID: PMC3608429.
    150. Lee S, Birukov KG, Romanoski CE, Springstead JR, Lusis A, Berliner JA. Role of phospholipid oxidation products in atherosclerosis. Circ Res. 2012 Aug 31; 111(6):778-99. PMID: 22935534; PMCID: PMC3563283.
    151. Ghazalpour A, Rau CD, Farber CR, Bennett BJ, Orozco LD, van Nas A, Pan C, Allayee H, Beaven SW, Civelek M, Davis RC, Drake TA, Friedman RA, Furlotte N, Hui ST, Jentsch JD, Kostem E, Kang HM, Kang EY, Joo JW, Korshunov VA, Laughlin RE, Martin LJ, Ohmen JD, Parks BW, Pellegrini M, Reue K, Smith DJ, Tetradis S, Wang J, Wang Y, Weiss JN, Kirchgessner T, Gargalovic PS, Eskin E, Lusis A, LeBoeuf RC. Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits. Mamm Genome. 2012 Oct; 23(9-10):680-92. PMID: 22892838; PMCID: PMC3586763.
    152. Weiss JN, Karma A, MacLellan WR, Deng M, Rau CD, Rees CM, Wang J, Wisniewski N, Eskin E, Horvath S, Qu Z, Wang Y, Lusis A. "Good enough solutions" and the genetics of complex diseases. Circ Res. 2012 Aug 03; 111(4):493-504. PMID: 22859671; PMCID: PMC3428228.
    153. Martin LJ, Lau E, Singh H, Vergnes L, Tarling EJ, Mehrabian M, Mungrue I, Xiao S, Shih D, Castellani L, Ping P, Reue K, Stefani E, Drake TA, Bostrom K, Lusis A. ABCC6 localizes to the mitochondria-associated membrane. Circ Res. 2012 Aug 17; 111(5):516-20. PMID: 22811557; PMCID: PMC3540978.
    154. Bennett BJ, Orozco L, Kostem E, Erbilgin A, Dallinga M, Neuhaus I, Guan B, Wang X, Eskin E, Lusis A. High-resolution association mapping of atherosclerosis loci in mice. Arterioscler Thromb Vasc Biol. 2012 Aug; 32(8):1790-8. PMID: 22723443; PMCID: PMC3519423.
    155. Smolock EM, Ilyushkina IA, Ghazalpour A, Gerloff J, Murashev AN, Lusis A, Korshunov VA. Genetic locus on mouse chromosome 7 controls elevated heart rate. Physiol Genomics. 2012 Jul 03; 44(13):689-98. PMID: 22589454; PMCID: PMC3426427.
    156. Stancáková A, Civelek M, Saleem NK, Soininen P, Kangas AJ, Cederberg H, Paananen J, Pihlajamäki J, Bonnycastle LL, Morken MA, Boehnke M, Pajukanta P, Lusis A, Collins FS, Kuusisto J, Ala-Korpela M, Laakso M. Hyperglycemia and a common variant of GCKR are associated with the levels of eight amino acids in 9,369 Finnish men. Diabetes. 2012 Jul; 61(7):1895-902. PMID: 22553379; PMCID: PMC3379649.
    157. Furlotte NA, Kang EY, Van Nas A, Farber CR, Lusis A, Eskin E. Increasing association mapping power and resolution in mouse genetic studies through the use of meta-analysis for structured populations. Genetics. 2012 Jul; 191(3):959-67. PMID: 22505625; PMCID: PMC3389987.
    158. Lusis A. Genetics of atherosclerosis. Trends Genet. 2012 Jun; 28(6):267-75. PMID: 22480919; PMCID: PMC3362664.
    159. Hong C, Bradley MN, Rong X, Wang X, Wagner A, Grijalva V, Castellani LW, Salazar J, Realegeno S, Boyadjian R, Fogelman AM, Van Lenten BJ, Reddy ST, Lusis A, Tangirala RK, Tontonoz P. LXRa is uniquely required for maximal reverse cholesterol transport and atheroprotection in ApoE-deficient mice. J Lipid Res. 2012 Jun; 53(6):1126-33. PMID: 22454476; PMCID: PMC3351819.
    160. Arnold AP, Lusis A. Understanding the sexome: measuring and reporting sex differences in gene systems. Endocrinology. 2012 Jun; 153(6):2551-5. PMID: 22434084; PMCID: PMC3359607.
    161. Lee S, Springstead JR, Parks BW, Romanoski CE, Palvolgyi R, Ho T, Nguyen P, Lusis A, Berliner JA. Metalloproteinase processing of HBEGF is a proximal event in the response of human aortic endothelial cells to oxidized phospholipids. Arterioscler Thromb Vasc Biol. 2012 May; 32(5):1246-54. PMID: 22402363; PMCID: PMC3357069.
    162. Casellas J, Gularte RJ, Farber CR, Varona L, Mehrabian M, Schadt EE, Lusis A, Attie AD, Yandell BS, Medrano JF. Genome scans for transmission ratio distortion regions in mice. Genetics. 2012 May; 191(1):247-59. PMID: 22367040; PMCID: PMC3338264.
    163. Ishikawa K, Navab M, Lusis A. Vasculitis, Atherosclerosis, and Altered HDL Composition in Heme-Oxygenase-1-Knockout Mice. Int J Hypertens. 2012; 2012:948203. PMID: 22518297; PMCID: PMC3296294.
    164. Lusis A. Life after GWAS: functional genomics in vascular biology. Arterioscler Thromb Vasc Biol. 2012 Feb; 32(2):169. PMID: 22258899; PMCID: PMC3934492.
    165. MacLellan WR, Wang Y, Lusis A. Systems-based approaches to cardiovascular disease. Nat Rev Cardiol. 2012 Jan 10; 9(3):172-84. PMID: 22231714; PMCID: PMC3823242.
    166. Terra JK, France B, Cote CK, Jenkins A, Bozue JA, Welkos SL, Bhargava R, Ho CL, Mehrabian M, Pan C, Lusis A, Davis RC, LeVine SM, Bradley KA. Allelic variation on murine chromosome 11 modifies host inflammatory responses and resistance to Bacillus anthracis. PLoS Pathog. 2011 Dec; 7(12):e1002469. PMID: 22241984; PMCID: PMC3248472.
    167. Johansen CT, Wang J, McIntyre AD, Martins RA, Ban MR, Lanktree MB, Huff MW, Péterfy M, Mehrabian M, Lusis A, Kathiresan S, Anand SS, Yusuf S, Lee AH, Glimcher LH, Cao H, Hegele RA. Excess of rare variants in non-genome-wide association study candidate genes in patients with hypertriglyceridemia. Circ Cardiovasc Genet. 2012 Feb 01; 5(1):66-72. PMID: 22135386; PMCID: PMC3288444.
    168. Kim JB, Xia YR, Romanoski CE, Lee S, Meng Y, Shi YS, Bourquard N, Gong KW, Port Z, Grijalva V, Reddy ST, Berliner JA, Lusis A, Shih DM. Paraoxonase-2 modulates stress response of endothelial cells to oxidized phospholipids and a bacterial quorum-sensing molecule. Arterioscler Thromb Vasc Biol. 2011 Nov; 31(11):2624-33. PMID: 21836061; PMCID: PMC3244174.
    169. Davis RC, van Nas A, Castellani LW, Zhao Y, Zhou Z, Wen P, Yu S, Qi H, Rosales M, Schadt EE, Broman KW, Péterfy M, Lusis A. Systems genetics of susceptibility to obesity-induced diabetes in mice. Physiol Genomics. 2012 Jan 18; 44(1):1-13. PMID: 22010005; PMCID: PMC3289122.
    170. Mungrue IN, Zhao P, Yao Y, Meng H, Rau C, Havel JV, Gorgels TG, Bergen AA, MacLellan WR, Drake TA, Boström KI, Lusis A. Abcc6 deficiency causes increased infarct size and apoptosis in a mouse cardiac ischemia-reperfusion model. Arterioscler Thromb Vasc Biol. 2011 Dec; 31(12):2806-12. PMID: 21979437; PMCID: PMC3227394.
    171. Langfelder P, Castellani LW, Zhou Z, Paul E, Davis R, Schadt EE, Lusis A, Horvath S, Mehrabian M. A systems genetic analysis of high density lipoprotein metabolism and network preservation across mouse models. Biochim Biophys Acta. 2012 Mar; 1821(3):435-47. PMID: 21807117; PMCID: PMC3265689.
    172. Romanoski CE, Che N, Yin F, Mai N, Pouldar D, Civelek M, Pan C, Lee S, Vakili L, Yang WP, Kayne P, Mungrue IN, Araujo JA, Berliner JA, Lusis A. Network for activation of human endothelial cells by oxidized phospholipids: a critical role of heme oxygenase 1. Circ Res. 2011 Aug 19; 109(5):e27-41. PMID: 21737788; PMCID: PMC3163234.
    173. Besler C, Heinrich K, Rohrer L, Doerries C, Riwanto M, Shih DM, Chroni A, Yonekawa K, Stein S, Schaefer N, Mueller M, Akhmedov A, Daniil G, Manes C, Templin C, Wyss C, Maier W, Tanner FC, Matter CM, Corti R, Furlong C, Lusis A, von Eckardstein A, Fogelman AM, Lüscher TF, Landmesser U. Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease. J Clin Invest. 2011 Jul; 121(7):2693-708. PMID: 21701070; PMCID: PMC3223817.
    174. Ghazalpour A, Bennett B, Petyuk VA, Orozco L, Hagopian R, Mungrue IN, Farber CR, Sinsheimer J, Kang HM, Furlotte N, Park CC, Wen PZ, Brewer H, Weitz K, Camp DG, Pan C, Yordanova R, Neuhaus I, Tilford C, Siemers N, Gargalovic P, Eskin E, Kirchgessner T, Smith DJ, Smith RD, Lusis A. Comparative analysis of proteome and transcriptome variation in mouse. PLoS Genet. 2011 Jun; 7(6):e1001393. PMID: 21695224; PMCID: PMC3111477.
    175. Civelek M, Lusis A. Conducting the metabolic syndrome orchestra. Nat Genet. 2011 Jun; 43(6):506-8. PMID: 21614088; PMCID: PMC3934506.
    176. Wang Z, Klipfell E, Bennett BJ, Koeth R, Levison BS, Dugar B, Feldstein AE, Britt EB, Fu X, Chung YM, Wu Y, Schauer P, Smith JD, Allayee H, Tang WH, DiDonato JA, Lusis A, Hazen SL. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature. 2011 Apr 07; 472(7341):57-63. PMID: 21475195; PMCID: PMC3086762.
    177. Farber CR, Bennett BJ, Orozco L, Zou W, Lira A, Kostem E, Kang HM, Furlotte N, Berberyan A, Ghazalpour A, Suwanwela J, Drake TA, Eskin E, Wang QT, Teitelbaum SL, Lusis A. Mouse genome-wide association and systems genetics identify Asxl2 as a regulator of bone mineral density and osteoclastogenesis. PLoS Genet. 2011 Apr; 7(4):e1002038. PMID: 21490954; PMCID: PMC3072371.
    178. Suwanwela J, Farber CR, Haung BL, Song B, Pan C, Lyons KM, Lusis A. Systems genetics analysis of mouse chondrocyte differentiation. J Bone Miner Res. 2011 Apr; 26(4):747-60. PMID: 20954177; PMCID: PMC3179327.
    179. Park CC, Gale GD, de Jong S, Ghazalpour A, Bennett BJ, Farber CR, Langfelder P, Lin A, Khan AH, Eskin E, Horvath S, Lusis A, Ophoff RA, Smith DJ. Gene networks associated with conditional fear in mice identified using a systems genetics approach. BMC Syst Biol. 2011 Mar 16; 5:43. PMID: 21410935; PMCID: PMC3070648.
    180. Barajas B, Che N, Yin F, Rowshanrad A, Orozco LD, Gong KW, Wang X, Castellani LW, Reue K, Lusis A, Araujo JA. NF-E2-related factor 2 promotes atherosclerosis by effects on plasma lipoproteins and cholesterol transport that overshadow antioxidant protection. Arterioscler Thromb Vasc Biol. 2011 Jan; 31(1):58-66. PMID: 20947826; PMCID: PMC3037185.
    181. Yao Y, Bennett BJ, Wang X, Rosenfeld ME, Giachelli C, Lusis A, Boström KI. Inhibition of bone morphogenetic proteins protects against atherosclerosis and vascular calcification. Circ Res. 2010 Aug 20; 107(4):485-94. PMID: 20576934; PMCID: PMC2994650.
    182. Yang X, Peterson L, Thieringer R, Deignan JL, Wang X, Zhu J, Wang S, Zhong H, Stepaniants S, Beaulaurier J, Wang IM, Rosa R, Cumiskey AM, Luo JM, Luo Q, Shah K, Xiao J, Nickle D, Plump A, Schadt EE, Lusis A, Lum PY. Identification and validation of genes affecting aortic lesions in mice. J Clin Invest. 2010 Jul; 120(7):2414-22. PMID: 20577049; PMCID: PMC2898611.
    183. Hsu YH, Zillikens MC, Wilson SG, Farber CR, Demissie S, Soranzo N, Bianchi EN, Grundberg E, Liang L, Richards JB, Estrada K, Zhou Y, van Nas A, Moffatt MF, Zhai G, Hofman A, van Meurs JB, Pols HA, Price RI, Nilsson O, Pastinen T, Cupples LA, Lusis A, Schadt EE, Ferrari S, Uitterlinden AG, Rivadeneira F, Spector TD, Karasik D, Kiel DP. An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits. PLoS Genet. 2010 Jun 10; 6(6):e1000977. PMID: 20548944; PMCID: PMC2883588.
    184. Woo JM, Lin Z, Navab M, Van Dyck C, Trejo-Lopez Y, Woo KM, Li H, Castellani LW, Wang X, Iikuni N, Rullo OJ, Wu H, La Cava A, Fogelman AM, Lusis A, Tsao BP. Treatment with apolipoprotein A-1 mimetic peptide reduces lupus-like manifestations in a murine lupus model of accelerated atherosclerosis. Arthritis Res Ther. 2010; 12(3):R93. PMID: 20482780; PMCID: PMC2911877.
    185. van Nas A, Ingram-Drake L, Sinsheimer JS, Wang SS, Schadt EE, Drake T, Lusis A. Expression quantitative trait loci: replication, tissue- and sex-specificity in mice. Genetics. 2010 Jul; 185(3):1059-68. PMID: 20439777; PMCID: PMC2907192.
    186. Davis RC, Castellani LW, Hosseini M, Ben-Zeev O, Mao HZ, Weinstein MM, Jung DY, Jun JY, Kim JK, Lusis A, Péterfy M. Early hepatic insulin resistance precedes the onset of diabetes in obese C57BLKS-db/db mice. Diabetes. 2010 Jul; 59(7):1616-25. PMID: 20393148; PMCID: PMC2889760.
    187. Tarling EJ, Bojanic DD, Tangirala RK, Wang X, Lovgren-Sandblom A, Lusis A, Bjorkhem I, Edwards PA. Impaired development of atherosclerosis in Abcg1-/- Apoe-/- mice: identification of specific oxysterols that both accumulate in Abcg1-/- Apoe-/- tissues and induce apoptosis. Arterioscler Thromb Vasc Biol. 2010 Jun; 30(6):1174-80. PMID: 20299684; PMCID: PMC2881948.
    188. Shaposhnik Z, Wang X, Lusis A. Arterial colony stimulating factor-1 influences atherosclerotic lesions by regulating monocyte migration and apoptosis. J Lipid Res. 2010 Jul; 51(7):1962-70. PMID: 20194110; PMCID: PMC2882747.
    189. Romanoski CE, Lee S, Kim MJ, Ingram-Drake L, Plaisier CL, Yordanova R, Tilford C, Guan B, He A, Gargalovic PS, Kirchgessner TG, Berliner JA, Lusis A. Systems genetics analysis of gene-by-environment interactions in human cells. Am J Hum Genet. 2010 Mar 12; 86(3):399-410. PMID: 20170901; PMCID: PMC2833388.
    190. Bennett BJ, Farber CR, Orozco L, Kang HM, Ghazalpour A, Siemers N, Neubauer M, Neuhaus I, Yordanova R, Guan B, Truong A, Yang WP, He A, Kayne P, Gargalovic P, Kirchgessner T, Pan C, Castellani LW, Kostem E, Furlotte N, Drake TA, Eskin E, Lusis A. A high-resolution association mapping panel for the dissection of complex traits in mice. Genome Res. 2010 Feb; 20(2):281-90. PMID: 20054062; PMCID: PMC2813484.
    191. Lusis A, Weiss JN. Cardiovascular networks: systems-based approaches to cardiovascular disease. Circulation. 2010 Jan 05; 121(1):157-70. PMID: 20048233; PMCID: PMC2836123.
    192. Shih DM, Xia YR, Yu JM, Lusis A. Temporal and tissue-specific patterns of Pon3 expression in mouse: in situ hybridization analysis. Adv Exp Med Biol. 2010; 660:73-87. PMID: 20221872; PMCID: PMC3018859.
    193. Gargalovic PS, Erbilgin A, Kohannim O, Pagnon J, Wang X, Castellani L, LeBoeuf R, Peterson ML, Spear BT, Lusis A. Quantitative trait locus mapping and identification of Zhx2 as a novel regulator of plasma lipid metabolism. Circ Cardiovasc Genet. 2010 Feb; 3(1):60-7. PMID: 20160197; PMCID: PMC2846770.
    194. Stoltz DA, Ozer EA, Recker TJ, Estin M, Yang X, Shih DM, Lusis A, Zabner J. A common mutation in paraoxonase-2 results in impaired lactonase activity. J Biol Chem. 2009 Dec 18; 284(51):35564-71. PMID: 19840942.
      View in: PubMed
    195. Priceman SJ, Sung JL, Shaposhnik Z, Burton JB, Torres-Collado AX, Moughon DL, Johnson M, Lusis A, Cohen DA, Iruela-Arispe ML, Wu L. Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy. Blood. 2010 Feb 18; 115(7):1461-71. PMID: 20008303; PMCID: PMC2826767.
    196. Wu S, Mar-Heyming R, Dugum EZ, Kolaitis NA, Qi H, Pajukanta P, Castellani LW, Lusis A, Drake TA. Upstream transcription factor 1 influences plasma lipid and metabolic traits in mice. Hum Mol Genet. 2010 Feb 15; 19(4):597-608. PMID: 19995791; PMCID: PMC2807368.
    197. Farber CR, Lusis A. Future of osteoporosis genetics: enhancing genome-wide association studies. J Bone Miner Res. 2009 Dec; 24(12):1937-42. PMID: 19888896; PMCID: PMC3626446.
    198. Wang SS, Martin LJ, Schadt EE, Meng H, Wang X, Zhao W, Ingram-Drake L, Nebohacova M, Mehrabian M, Drake TA, Lusis A. Disruption of the aortic elastic lamina and medial calcification share genetic determinants in mice. Circ Cardiovasc Genet. 2009 Dec; 2(6):573-82. PMID: 20031637; PMCID: PMC2836127.
    199. Weinstein MM, Yin L, Tu Y, Wang X, Wu X, Castellani LW, Walzem RL, Lusis A, Fong LG, Beigneux AP, Young SG. Chylomicronemia elicits atherosclerosis in mice--brief report. Arterioscler Thromb Vasc Biol. 2010 Jan; 30(1):20-3. PMID: 19815815; PMCID: PMC2796285.
    200. Arnold AP, van Nas A, Lusis A. Systems biology asks new questions about sex differences. Trends Endocrinol Metab. 2009 Dec; 20(10):471-6. PMID: 19783453; PMCID: PMC2787703.
    201. Shih DM, Lusis A. The roles of PON1 and PON2 in cardiovascular disease and innate immunity. Curr Opin Lipidol. 2009 Aug; 20(4):288-92. PMID: 19474728; PMCID: PMC3869948.
    202. Orozco LD, Cokus SJ, Ghazalpour A, Ingram-Drake L, Wang S, van Nas A, Che N, Araujo JA, Pellegrini M, Lusis A. Copy number variation influences gene expression and metabolic traits in mice. Hum Mol Genet. 2009 Nov 01; 18(21):4118-29. PMID: 19648292; PMCID: PMC2758141.
    203. White CH, Ohmen JD, Sheth S, Zebboudj AF, McHugh RK, Hoffman LF, Lusis A, Davis RC, Friedman RA. Genome-wide screening for genetic loci associated with noise-induced hearing loss. Mamm Genome. 2009 Apr; 20(4):207-13. PMID: 19337678; PMCID: PMC2823581.
    204. Farber CR, Aten JE, Farber EA, de Vera V, Gularte R, Islas-Trejo A, Wen P, Horvath S, Lucero M, Lusis A, Medrano JF. Genetic dissection of a major mouse obesity QTL (Carfhg2): integration of gene expression and causality modeling. Physiol Genomics. 2009 May 13; 37(3):294-302. PMID: 19336533; PMCID: PMC2685499.
    205. Yang X, Deignan JL, Qi H, Zhu J, Qian S, Zhong J, Torosyan G, Majid S, Falkard B, Kleinhanz RR, Karlsson J, Castellani LW, Mumick S, Wang K, Xie T, Coon M, Zhang C, Estrada-Smith D, Farber CR, Wang SS, van Nas A, Ghazalpour A, Zhang B, Macneil DJ, Lamb JR, Dipple KM, Reitman ML, Mehrabian M, Lum PY, Schadt EE, Lusis A, Drake TA. Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks. Nat Genet. 2009 Apr; 41(4):415-23. PMID: 19270708; PMCID: PMC2837947.
    206. Bennett BJ, Wang SS, Wang X, Wu X, Lusis A. Genetic regulation of atherosclerotic plaque size and morphology in the innominate artery of hyperlipidemic mice. Arterioscler Thromb Vasc Biol. 2009 Mar; 29(3):348-55. PMID: 19122174; PMCID: PMC2704985.
    207. Mungrue IN, Pagnon J, Kohannim O, Gargalovic PS, Lusis A. CHAC1/MGC4504 is a novel proapoptotic component of the unfolded protein response, downstream of the ATF4-ATF3-CHOP cascade. J Immunol. 2009 Jan 01; 182(1):466-76. PMID: 19109178; PMCID: PMC2846782.
    208. Farber CR, van Nas A, Ghazalpour A, Aten JE, Doss S, Sos B, Schadt EE, Ingram-Drake L, Davis RC, Horvath S, Smith DJ, Drake TA, Lusis A. An integrative genetics approach to identify candidate genes regulating BMD: combining linkage, gene expression, and association. J Bone Miner Res. 2009 Jan; 24(1):105-16. PMID: 18767929; PMCID: PMC2661539.
    209. Bhasin KK, van Nas A, Martin LJ, Davis RC, Devaskar SU, Lusis A. Maternal low-protein diet or hypercholesterolemia reduces circulating essential amino acids and leads to intrauterine growth restriction. Diabetes. 2009 Mar; 58(3):559-66. PMID: 19073773; PMCID: PMC2646054.
    210. Wu S, Lusis A, Drake TA. A systems-based framework for understanding complex metabolic and cardiovascular disorders. J Lipid Res. 2009 Apr; 50 Suppl:S358-63. PMID: 19033210; PMCID: PMC2674684.
    211. Shaposhnik Z, Wang X, Trias J, Fraser H, Lusis A. The synergistic inhibition of atherogenesis in apoE-/- mice between pravastatin and the sPLA2 inhibitor varespladib (A-002). J Lipid Res. 2009 Apr; 50(4):623-9. PMID: 19029066; PMCID: PMC2656655.
    212. Lusis A, Attie AD, Reue K. Metabolic syndrome: from epidemiology to systems biology. Nat Rev Genet. 2008 Nov; 9(11):819-30. PMID: 18852695; PMCID: PMC2829312.
    213. van Nas A, Guhathakurta D, Wang SS, Yehya N, Horvath S, Zhang B, Ingram-Drake L, Chaudhuri G, Schadt EE, Drake TA, Arnold AP, Lusis A. Elucidating the role of gonadal hormones in sexually dimorphic gene coexpression networks. Endocrinology. 2009 Mar; 150(3):1235-49. PMID: 18974276; PMCID: PMC2654741.
    214. Allayee H, Baylin A, Hartiala J, Wijesuriya H, Mehrabian M, Lusis A, Campos H. Nutrigenetic association of the 5-lipoxygenase gene with myocardial infarction. Am J Clin Nutr. 2008 Oct; 88(4):934-40. PMID: 18842779.
      View in: PubMed
    215. Ghazalpour A, Doss S, Kang H, Farber C, Wen PZ, Brozell A, Castellanos R, Eskin E, Smith DJ, Drake TA, Lusis A. High-resolution mapping of gene expression using association in an outbred mouse stock. PLoS Genet. 2008 Aug 08; 4(8):e1000149. PMID: 18688273; PMCID: PMC2483929.
    216. Chen J, Hui ST, Couto FM, Mungrue IN, Davis DB, Attie AD, Lusis A, Davis RA, Shalev A. Thioredoxin-interacting protein deficiency induces Akt/Bcl-xL signaling and pancreatic beta-cell mass and protects against diabetes. FASEB J. 2008 Oct; 22(10):3581-94. PMID: 18552236; PMCID: PMC2537437.
    217. Schadt EE, Molony C, Chudin E, Hao K, Yang X, Lum PY, Kasarskis A, Zhang B, Wang S, Suver C, Zhu J, Millstein J, Sieberts S, Lamb J, GuhaThakurta D, Derry J, Storey JD, Avila-Campillo I, Kruger MJ, Johnson JM, Rohl CA, van Nas A, Mehrabian M, Drake TA, Lusis A, Smith RC, Guengerich FP, Strom SC, Schuetz E, Rushmore TH, Ulrich R. Mapping the genetic architecture of gene expression in human liver. PLoS Biol. 2008 May 06; 6(5):e107. PMID: 18462017; PMCID: PMC2365981.
    218. Oskolkova OV, Afonyushkin T, Leitner A, von Schlieffen E, Gargalovic PS, Lusis A, Binder BR, Bochkov VN. ATF4-dependent transcription is a key mechanism in VEGF up-regulation by oxidized phospholipids: critical role of oxidized sn-2 residues in activation of unfolded protein response. Blood. 2008 Jul 15; 112(2):330-9. PMID: 18451308; PMCID: PMC2442744.
    219. Aten JE, Fuller TF, Lusis A, Horvath S. Using genetic markers to orient the edges in quantitative trait networks: the NEO software. BMC Syst Biol. 2008 Apr 15; 2:34. PMID: 18412962; PMCID: PMC2387136.
    220. Park CC, Ahn S, Bloom JS, Lin A, Wang RT, Wu T, Sekar A, Khan AH, Farr CJ, Lusis A, Leahy RM, Lange K, Smith DJ. Fine mapping of regulatory loci for mammalian gene expression using radiation hybrids. Nat Genet. 2008 Apr; 40(4):421-9. PMID: 18362883; PMCID: PMC3014048.
    221. Bhattacharyya T, Nicholls SJ, Topol EJ, Zhang R, Yang X, Schmitt D, Fu X, Shao M, Brennan DM, Ellis SG, Brennan ML, Allayee H, Lusis A, Hazen SL. Relationship of paraoxonase 1 (PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk. JAMA. 2008 Mar 19; 299(11):1265-76. PMID: 18349088; PMCID: PMC3014051.
    222. Chen Y, Zhu J, Lum PY, Yang X, Pinto S, MacNeil DJ, Zhang C, Lamb J, Edwards S, Sieberts SK, Leonardson A, Castellini LW, Wang S, Champy MF, Zhang B, Emilsson V, Doss S, Ghazalpour A, Horvath S, Drake TA, Lusis A, Schadt EE. Variations in DNA elucidate molecular networks that cause disease. Nature. 2008 Mar 27; 452(7186):429-35. PMID: 18344982; PMCID: PMC2841398.
    223. Mar-Heyming R, Miyazaki M, Weissglas-Volkov D, Kolaitis NA, Sadaat N, Plaisier C, Pajukanta P, Cantor RM, de Bruin TW, Ntambi JM, Lusis A. Association of stearoyl-CoA desaturase 1 activity with familial combined hyperlipidemia. Arterioscler Thromb Vasc Biol. 2008 Jun; 28(6):1193-9. PMID: 18340007; PMCID: PMC2758768.
    224. Lusis A, Pajukanta P. A treasure trove for lipoprotein biology. Nat Genet. 2008 Feb; 40(2):129-30. PMID: 18227868.
      View in: PubMed
    225. Araujo JA, Barajas B, Kleinman M, Wang X, Bennett BJ, Gong KW, Navab M, Harkema J, Sioutas C, Lusis A, Nel AE. Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stress. Circ Res. 2008 Mar 14; 102(5):589-96. PMID: 18202315; PMCID: PMC3014059.
    226. Chen J, Saxena G, Mungrue IN, Lusis A, Shalev A. Thioredoxin-interacting protein: a critical link between glucose toxicity and beta-cell apoptosis. Diabetes. 2008 Apr; 57(4):938-44. PMID: 18171713; PMCID: PMC3618659.
    227. Farber CR, Lusis A. Integrating global gene expression analysis and genetics. Adv Genet. 2008; 60:571-601. PMID: 18358333; PMCID: PMC3109657.
    228. Castellani LW, Nguyen CN, Charugundla S, Weinstein MM, Doan CX, Blaner WS, Wongsiriroj N, Lusis A. Apolipoprotein AII is a regulator of very low density lipoprotein metabolism and insulin resistance. J Biol Chem. 2008 Apr 25; 283(17):11633-44. PMID: 18160395; PMCID: PMC2431075.
    229. Bennett BJ, Romanoski CE, Lusis A. Network-centered view of coronary artery disease. Expert Rev Cardiovasc Ther. 2007 Nov; 5(6):1095-103. PMID: 18035925.
      View in: PubMed
    230. Péterfy M, Davis RC, Lusis A. Metabolic syndrome as a modifier of atherosclerosis in murine models. Curr Drug Targets. 2007 Nov; 8(11):1215-20. PMID: 18045100.
      View in: PubMed
    231. McLin JP, Thompson LM, Lusis A, Davis RC, Steward O. Genes on distal chromosome 18 determine vulnerability to excitotoxic neurodegeneration following status epilepticus, but not striatal neurodegeneration induced by quinolinic acid. Neurobiol Dis. 2008 Mar; 29(3):391-9. PMID: 17996456.
      View in: PubMed
    232. Wang SS, Shi W, Wang X, Velky L, Greenlee S, Wang MT, Drake TA, Lusis A. Mapping, genetic isolation, and characterization of genetic loci that determine resistance to atherosclerosis in C3H mice. Arterioscler Thromb Vasc Biol. 2007 Dec; 27(12):2671-6. PMID: 17916774.
      View in: PubMed
    233. Martin LJ, Chen H, Liao X, Allayee H, Shih DM, Lee GS, Hovland DN, Robbins WA, Carnes K, Hess RA, Lusis A, Collins MD. FK506, a calcineurin inhibitor, prevents cadmium-induced testicular toxicity in mice. Toxicol Sci. 2007 Dec; 100(2):474-85. PMID: 17785681.
      View in: PubMed
    234. Lusis A, Yu J, Wang SS. The problem of passenger genes in transgenic mice. Arterioscler Thromb Vasc Biol. 2007 Oct; 27(10):2100-3. PMID: 17690316.
      View in: PubMed
    235. Lee JC, Weissglas-Volkov D, Kyttälä M, Sinsheimer JS, Jokiaho A, de Bruin TW, Lusis A, Brennan ML, van Greevenbroek MM, van der Kallen CJ, Hazen SL, Pajukanta P. USF1 contributes to high serum lipid levels in Dutch FCHL families and U.S. whites with coronary artery disease. Arterioscler Thromb Vasc Biol. 2007 Oct; 27(10):2222-7. PMID: 17673701.
      View in: PubMed
    236. Bradley MN, Hong C, Chen M, Joseph SB, Wilpitz DC, Wang X, Lusis A, Collins A, Hseuh WA, Collins JL, Tangirala RK, Tontonoz P. Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE. J Clin Invest. 2007 Aug; 117(8):2337-46. PMID: 17657314; PMCID: PMC1924496.
    237. Fuller TF, Ghazalpour A, Aten JE, Drake TA, Lusis A, Horvath S. Weighted gene coexpression network analysis strategies applied to mouse weight. Mamm Genome. 2007 Jul; 18(6-7):463-72. PMID: 17668265; PMCID: PMC1998880.
    238. Wang SS, Schadt EE, Wang H, Wang X, Ingram-Drake L, Shi W, Drake TA, Lusis A. Identification of pathways for atherosclerosis in mice: integration of quantitative trait locus analysis and global gene expression data. Circ Res. 2007 Aug 03; 101(3):e11-30. PMID: 17641228.
      View in: PubMed
    239. Moen CJ, Tholens AP, Voshol PJ, de Haan W, Havekes LM, Gargalovic P, Lusis A, van Dyk KW, Frants RR, Hofker MH, Rensen PC. The Hyplip2 locus causes hypertriglyceridemia by decreased clearance of triglycerides. J Lipid Res. 2007 Oct; 48(10):2182-92. PMID: 17609525.
      View in: PubMed
    240. Davis RC, Jin A, Rosales M, Yu S, Xia X, Ranola K, Schadt EE, Lusis A. A genome-wide set of congenic mouse strains derived from CAST/Ei on a C57BL/6 background. Genomics. 2007 Sep; 90(3):306-13. PMID: 17600671.
      View in: PubMed
    241. Orozco LD, Kapturczak MH, Barajas B, Wang X, Weinstein MM, Wong J, Deshane J, Bolisetty S, Shaposhnik Z, Shih DM, Agarwal A, Lusis A, Araujo JA. Heme oxygenase-1 expression in macrophages plays a beneficial role in atherosclerosis. Circ Res. 2007 Jun 22; 100(12):1703-11. PMID: 17495224.
      View in: PubMed
    242. Shih DM, Xia YR, Wang XP, Wang SS, Bourquard N, Fogelman AM, Lusis A, Reddy ST. Decreased obesity and atherosclerosis in human paraoxonase 3 transgenic mice. Circ Res. 2007 Apr 27; 100(8):1200-7. PMID: 17379834; PMCID: PMC3740095.
    243. Gharavi NM, Gargalovic PS, Chang I, Araujo JA, Clark MJ, Szeto WL, Watson AD, Lusis A, Berliner JA. High-density lipoprotein modulates oxidized phospholipid signaling in human endothelial cells from proinflammatory to anti-inflammatory. Arterioscler Thromb Vasc Biol. 2007 Jun; 27(6):1346-53. PMID: 17379837.
      View in: PubMed
    244. Meng H, Vera I, Che N, Wang X, Wang SS, Ingram-Drake L, Schadt EE, Drake TA, Lusis A. Identification of Abcc6 as the major causal gene for dystrophic cardiac calcification in mice through integrative genomics. Proc Natl Acad Sci U S A. 2007 Mar 13; 104(11):4530-5. PMID: 17360558; PMCID: PMC1838635.
    245. Feng X, Li H, Rumbin AA, Wang X, La Cava A, Brechtelsbauer K, Castellani LW, Witztum JL, Lusis A, Tsao BP. ApoE-/-Fas-/- C57BL/6 mice: a novel murine model simultaneously exhibits lupus nephritis, atherosclerosis, and osteopenia. J Lipid Res. 2007 Apr; 48(4):794-805. PMID: 17259598.
      View in: PubMed
    246. Gong KW, Zhao W, Li N, Barajas B, Kleinman M, Sioutas C, Horvath S, Lusis A, Nel A, Araujo JA. Air-pollutant chemicals and oxidized lipids exhibit genome-wide synergistic effects on endothelial cells. Genome Biol. 2007; 8(7):R149. PMID: 17655762; PMCID: PMC2323217.
    247. Itoh Y, Melamed E, Yang X, Kampf K, Wang S, Yehya N, Van Nas A, Replogle K, Band MR, Clayton DF, Schadt EE, Lusis A, Arnold AP. Dosage compensation is less effective in birds than in mammals. J Biol. 2007; 6(1):2. PMID: 17352797; PMCID: PMC2373894.
    248. Shaposhnik Z, Wang X, Weinstein M, Bennett BJ, Lusis A. Granulocyte macrophage colony-stimulating factor regulates dendritic cell content of atherosclerotic lesions. Arterioscler Thromb Vasc Biol. 2007 Mar; 27(3):621-7. PMID: 17158354; PMCID: PMC3014056.
    249. Stoltz DA, Ozer EA, Ng CJ, Yu JM, Reddy ST, Lusis A, Bourquard N, Parsek MR, Zabner J, Shih DM. Paraoxonase-2 deficiency enhances Pseudomonas aeruginosa quorum sensing in murine tracheal epithelia. Am J Physiol Lung Cell Mol Physiol. 2007 Apr; 292(4):L852-60. PMID: 17122353.
      View in: PubMed
    250. Parks BW, Lusis A, Kabarowski JH. Loss of the lysophosphatidylcholine effector, G2A, ameliorates aortic atherosclerosis in low-density lipoprotein receptor knockout mice. Arterioscler Thromb Vasc Biol. 2006 Dec; 26(12):2703-9. PMID: 16990555.
      View in: PubMed
    251. Brouwers MC, Cantor RM, Kono N, Yoon JL, van der Kallen CJ, Bilderbeek-Beckers MA, van Greevenbroek MM, Lusis A, de Bruin TW. Heritability and genetic loci of fatty liver in familial combined hyperlipidemia. J Lipid Res. 2006 Dec; 47(12):2799-807. PMID: 16971732.
      View in: PubMed
    252. Lusis A. A thematic review series: systems biology approaches to metabolic and cardiovascular disorders. J Lipid Res. 2006 Sep; 47(9):1887-90. PMID: 16924129.
      View in: PubMed
    253. Gargalovic PS, Gharavi NM, Clark MJ, Pagnon J, Yang WP, He A, Truong A, Baruch-Oren T, Berliner JA, Kirchgessner TG, Lusis A. The unfolded protein response is an important regulator of inflammatory genes in endothelial cells. Arterioscler Thromb Vasc Biol. 2006 Nov; 26(11):2490-6. PMID: 16931790.
      View in: PubMed
    254. Gargalovic PS, Imura M, Zhang B, Gharavi NM, Clark MJ, Pagnon J, Yang WP, He A, Truong A, Patel S, Nelson SF, Horvath S, Berliner JA, Kirchgessner TG, Lusis A. Identification of inflammatory gene modules based on variations of human endothelial cell responses to oxidized lipids. Proc Natl Acad Sci U S A. 2006 Aug 22; 103(34):12741-6. PMID: 16912112; PMCID: PMC1568918.
    255. Ng CJ, Bourquard N, Grijalva V, Hama S, Shih DM, Navab M, Fogelman AM, Lusis A, Young S, Reddy ST. Paraoxonase-2 deficiency aggravates atherosclerosis in mice despite lower apolipoprotein-B-containing lipoproteins: anti-atherogenic role for paraoxonase-2. J Biol Chem. 2006 Oct 06; 281(40):29491-500. PMID: 16891303.
      View in: PubMed
    256. Estrada-Smith D, Collins AR, Wang X, Crockett C, Castellani L, Lusis A, Davis RC. Impact of chromosome 2 obesity loci on cardiovascular complications of insulin resistance in LDL receptor-deficient C57BL/6 mice. Diabetes. 2006 Aug; 55(8):2265-71. PMID: 16873689.
      View in: PubMed
    257. Zhang Y, Wang X, Vales C, Lee FY, Lee H, Lusis A, Edwards PA. FXR deficiency causes reduced atherosclerosis in Ldlr-/- mice. Arterioscler Thromb Vasc Biol. 2006 Oct; 26(10):2316-21. PMID: 16825595.
      View in: PubMed
    258. Yang X, Schadt EE, Wang S, Wang H, Arnold AP, Ingram-Drake L, Drake TA, Lusis A. Tissue-specific expression and regulation of sexually dimorphic genes in mice. Genome Res. 2006 Aug; 16(8):995-1004. PMID: 16825664; PMCID: PMC1524872.
    259. Ghazalpour A, Doss S, Zhang B, Wang S, Plaisier C, Castellanos R, Brozell A, Schadt EE, Drake TA, Lusis A, Horvath S. Integrating genetic and network analysis to characterize genes related to mouse weight. PLoS Genet. 2006 Aug 18; 2(8):e130. PMID: 16934000; PMCID: PMC1550283.
    260. Drake TA, Schadt EE, Lusis A. Integrating genetic and gene expression data: application to cardiovascular and metabolic traits in mice. Mamm Genome. 2006 Jun; 17(6):466-79. PMID: 16783628; PMCID: PMC2679634.
    261. Brouwers MC, Kono N, van Greevenbroek MM, van der Kallen CJ, Lusis A, de Bruin TW, Cantor RM. Longitudinal differences in familial combined hyperlipidemia quantitative trait loci. Arterioscler Thromb Vasc Biol. 2006 Jun; 26(6):e118-9. PMID: 16709947.
      View in: PubMed
    262. Bhasin KK, Yu JM, Tward A, Shih D, Campbell DA, Lusis A. Trypanosoma congolense: paraoxonase 1 prolongs survival of infected mice. Exp Parasitol. 2006 Nov; 114(3):240-5. PMID: 16682028.
      View in: PubMed
    263. Castellani LW, Chang JJ, Wang X, Lusis A, Reynolds WF. Transgenic mice express human MPO -463G/A alleles at atherosclerotic lesions, developing hyperlipidemia and obesity in -463G males. J Lipid Res. 2006 Jul; 47(7):1366-77. PMID: 16639078.
      View in: PubMed
    264. Ghazalpour A, Wang X, Lusis A, Mehrabian M. Complex inheritance of the 5-lipoxygenase locus influencing atherosclerosis in mice. Genetics. 2006 Jun; 173(2):943-51. PMID: 16624897; PMCID: PMC1526544.
    265. Su Z, Li Y, James JC, Matsumoto AH, Helm GA, Lusis A, Shi W. Genetic linkage of hyperglycemia, body weight and serum amyloid-P in an intercross between C57BL/6 and C3H apolipoprotein E-deficient mice. Hum Mol Genet. 2006 May 15; 15(10):1650-8. PMID: 16595606.
      View in: PubMed
    266. Lee JC, Lusis A, Pajukanta P. Familial combined hyperlipidemia: upstream transcription factor 1 and beyond. Curr Opin Lipidol. 2006 Apr; 17(2):101-9. PMID: 16531745.
      View in: PubMed
    267. Lum PY, Chen Y, Zhu J, Lamb J, Melmed S, Wang S, Drake TA, Lusis A, Schadt EE. Elucidating the murine brain transcriptional network in a segregating mouse population to identify core functional modules for obesity and diabetes. J Neurochem. 2006 Apr; 97 Suppl 1:50-62. PMID: 16635250.
      View in: PubMed
    268. Miyoshi T, Li Y, Shih DM, Wang X, Laubach VE, Matsumoto AH, Helm GA, Lusis A, Shi W. Deficiency of inducible NO synthase reduces advanced but not early atherosclerosis in apolipoprotein E-deficient mice. Life Sci. 2006 Jul 04; 79(6):525-31. PMID: 16516241.
      View in: PubMed
    269. Wang S, Yehya N, Schadt EE, Wang H, Drake TA, Lusis A. Genetic and genomic analysis of a fat mass trait with complex inheritance reveals marked sex specificity. PLoS Genet. 2006 Feb; 2(2):e15. PMID: 16462940; PMCID: PMC1359071.
    270. Su Z, Li Y, James JC, McDuffie M, Matsumoto AH, Helm GA, Weber JL, Lusis A, Shi W. Quantitative trait locus analysis of atherosclerosis in an intercross between C57BL/6 and C3H mice carrying the mutant apolipoprotein E gene. Genetics. 2006 Mar; 172(3):1799-807. PMID: 16387874; PMCID: PMC1456315.
    271. Shih DM, Kast-Woelbern HR, Wong J, Xia YR, Edwards PA, Lusis A. A role for FXR and human FGF-19 in the repression of paraoxonase-1 gene expression by bile acids. J Lipid Res. 2006 Feb; 47(2):384-92. PMID: 16269825.
      View in: PubMed
    272. Drake TA, Schadt EE, Davis RC, Lusis A. Integrating genetic and gene expression data to study the metabolic syndrome and diabetes in mice. Am J Ther. 2005 Nov-Dec; 12(6):503-11. PMID: 16280644.
      View in: PubMed
    273. Ozer EA, Pezzulo A, Shih DM, Chun C, Furlong C, Lusis A, Greenberg EP, Zabner J. Human and murine paraoxonase 1 are host modulators of Pseudomonas aeruginosa quorum-sensing. FEMS Microbiol Lett. 2005 Dec 01; 253(1):29-37. PMID: 16260097.
      View in: PubMed
    274. Mehrabian M, Allayee H, Stockton J, Lum PY, Drake TA, Castellani LW, Suh M, Armour C, Edwards S, Lamb J, Lusis A, Schadt EE. Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits. Nat Genet. 2005 Nov; 37(11):1224-33. PMID: 16200066.
      View in: PubMed
    275. Davis RC, Schadt EE, Smith DJ, Hsieh EW, Cervino AC, van Nas A, Rosales M, Doss S, Meng H, Allayee H, Lusis A. A genome-wide set of congenic mouse strains derived from DBA/2J on a C57BL/6J background. Genomics. 2005 Sep; 86(3):259-70. PMID: 16039824.
      View in: PubMed
    276. Cervino AC, Li G, Edwards S, Zhu J, Laurie C, Tokiwa G, Lum PY, Wang S, Castellani LW, Castellini LW, Lusis A, Carlson S, Sachs AB, Schadt EE. Integrating QTL and high-density SNP analyses in mice to identify Insig2 as a susceptibility gene for plasma cholesterol levels. Genomics. 2005 Nov; 86(5):505-17. PMID: 16126366.
      View in: PubMed
    277. Furlong CE, Cole TB, Jarvik GP, Pettan-Brewer C, Geiss GK, Richter RJ, Shih DM, Tward AD, Lusis A, Costa LG. Role of paraoxonase (PON1) status in pesticide sensitivity: genetic and temporal determinants. Neurotoxicology. 2005 Aug; 26(4):651-9. PMID: 16112327.
      View in: PubMed
    278. Cole TB, Walter BJ, Shih DM, Tward AD, Lusis A, Timchalk C, Richter RJ, Costa LG, Furlong CE. Toxicity of chlorpyrifos and chlorpyrifos oxon in a transgenic mouse model of the human paraoxonase (PON1) Q192R polymorphism. Pharmacogenet Genomics. 2005 Aug; 15(8):589-98. PMID: 16007003.
      View in: PubMed
    279. Ghazalpour A, Doss S, Sheth SS, Ingram-Drake LA, Schadt EE, Lusis A, Drake TA. Genomic analysis of metabolic pathway gene expression in mice. Genome Biol. 2005; 6(7):R59. PMID: 15998448; PMCID: PMC1175990.
    280. Huertas-Vazquez A, Aguilar-Salinas C, Lusis A, Cantor RM, Canizales-Quinteros S, Lee JC, Mariana-Nuñez L, Riba-Ramirez RM, Jokiaho A, Tusie-Luna T, Pajukanta P. Familial combined hyperlipidemia in Mexicans: association with upstream transcription factor 1 and linkage on chromosome 16q24.1. Arterioscler Thromb Vasc Biol. 2005 Sep; 25(9):1985-91. PMID: 15976322.
      View in: PubMed
    281. Schadt EE, Lamb J, Yang X, Zhu J, Edwards S, Guhathakurta D, Sieberts SK, Monks S, Reitman M, Zhang C, Lum PY, Leonardson A, Thieringer R, Metzger JM, Yang L, Castle J, Zhu H, Kash SF, Drake TA, Sachs A, Lusis A. An integrative genomics approach to infer causal associations between gene expression and disease. Nat Genet. 2005 Jul; 37(7):710-7. PMID: 15965475; PMCID: PMC2841396.
    282. Doss S, Schadt EE, Drake TA, Lusis A. Cis-acting expression quantitative trait loci in mice. Genome Res. 2005 May; 15(5):681-91. PMID: 15837804; PMCID: PMC1088296.
    283. Parks BW, Gambill GP, Lusis A, Kabarowski JH. Loss of G2A promotes macrophage accumulation in atherosclerotic lesions of low density lipoprotein receptor-deficient mice. J Lipid Res. 2005 Jul; 46(7):1405-15. PMID: 15834123.
      View in: PubMed
    284. Davis RC, Schadt EE, Cervino AC, Péterfy M, Lusis A. Ultrafine mapping of SNPs from mouse strains C57BL/6J, DBA/2J, and C57BLKS/J for loci contributing to diabetes and atherosclerosis susceptibility. Diabetes. 2005 Apr; 54(4):1191-9. PMID: 15793261.
      View in: PubMed
    285. Nguyen HX, Lusis A, Tidball JG. Null mutation of myeloperoxidase in mice prevents mechanical activation of neutrophil lysis of muscle cell membranes in vitro and in vivo. J Physiol. 2005 Jun 01; 565(Pt 2):403-13. PMID: 15790660; PMCID: PMC1464517.
    286. Furlong CE, Cole TB, Walter BJ, Shih DM, Tward A, Lusis A, Timchalk C, Richter RJ, Costa LG. Paraoxonase 1 (PON1) status and risk of insecticide exposure. J Biochem Mol Toxicol. 2005; 19(3):182-3. PMID: 15977192.
      View in: PubMed
    287. Sheth SS, Castellani LW, Chari S, Wagg C, Thipphavong CK, Bodnar JS, Tontonoz P, Attie AD, Lopaschuk GD, Lusis A. Thioredoxin-interacting protein deficiency disrupts the fasting-feeding metabolic transition. J Lipid Res. 2005 Jan; 46(1):123-34. PMID: 15520447.
      View in: PubMed
    288. Churchill GA, Airey DC, Allayee H, Angel JM, Attie AD, Beatty J, Beavis WD, Belknap JK, Bennett B, Berrettini W, Bleich A, Bogue M, Broman KW, Buck KJ, Buckler E, Burmeister M, Chesler EJ, Cheverud JM, Clapcote S, Cook MN, Cox RD, Crabbe JC, Crusio WE, Darvasi A, Deschepper CF, Doerge RW, Farber CR, Forejt J, Gaile D, Garlow SJ, Geiger H, Gershenfeld H, Gordon T, Gu J, Gu W, de Haan G, Hayes NL, Heller C, Himmelbauer H, Hitzemann R, Hunter K, Hsu HC, Iraqi FA, Ivandic B, Jacob HJ, Jansen RC, Jepsen KJ, Johnson DK, Johnson TE, Kempermann G, Kendziorski C, Kotb M, Kooy RF, Llamas B, Lammert F, Lassalle JM, Lowenstein PR, Lu L, Lusis A, Manly KF, Marcucio R, Matthews D, Medrano JF, Miller DR, Mittleman G, Mock BA, Mogil JS, Montagutelli X, Morahan G, Morris DG, Mott R, Nadeau JH, Nagase H, Nowakowski RS, O'Hara BF, Osadchuk AV, Page GP, Paigen B, Paigen K, Palmer AA, Pan HJ, Peltonen-Palotie L, Peirce J, Pomp D, Pravenec M, Prows DR, Qi Z, Reeves RH, Roder J, Rosen GD, Schadt EE, Schalkwyk LC, Seltzer Z, Shimomura K, Shou S, Sillanpää MJ, Siracusa LD, Snoeck HW, Spearow JL, Svenson K, Tarantino LM, Threadgill D, Toth LA, Valdar W, de Villena FP, Warden C, Whatley S, Williams RW, Wiltshire T, Yi N, Zhang D, Zhang M, Zou F. The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet. 2004 Nov; 36(11):1133-7. PMID: 15514660.
      View in: PubMed
    289. Lusis A, Fogelman AM, Fonarow GC. Genetic basis of atherosclerosis: part II: clinical implications. Circulation. 2004 Oct 05; 110(14):2066-71. PMID: 15466657.
      View in: PubMed
    290. Castellani LW, Gargalovic P, Febbraio M, Charugundla S, Jien ML, Lusis A. Mechanisms mediating insulin resistance in transgenic mice overexpressing mouse apolipoprotein A-II. J Lipid Res. 2004 Dec; 45(12):2377-87. PMID: 15466364.
      View in: PubMed
    291. Lusis A, Fogelman AM, Fonarow GC. Genetic basis of atherosclerosis: part I: new genes and pathways. Circulation. 2004 Sep 28; 110(13):1868-73. PMID: 15451808.
      View in: PubMed
    292. Rothfork JM, Timmins GS, Harris MN, Chen X, Lusis A, Otto M, Cheung AL, Gresham HD. Inactivation of a bacterial virulence pheromone by phagocyte-derived oxidants: new role for the NADPH oxidase in host defense. Proc Natl Acad Sci U S A. 2004 Sep 21; 101(38):13867-72. PMID: 15353593; PMCID: PMC518845.
    293. Wang X, Gargalovic P, Wong J, Gu JL, Wu X, Qi H, Wen P, Xi L, Tan B, Gogliotti R, Castellani LW, Chatterjee A, Lusis A. Hyplip2, a new gene for combined hyperlipidemia and increased atherosclerosis. Arterioscler Thromb Vasc Biol. 2004 Oct; 24(10):1928-34. PMID: 15331434.
      View in: PubMed
    294. Cantor RM, de Bruin T, Kono N, Napier S, van Nas A, Allayee H, Lusis A. Quantitative trait loci for apolipoprotein B, cholesterol, and triglycerides in familial combined hyperlipidemia pedigrees. Arterioscler Thromb Vasc Biol. 2004 Oct; 24(10):1935-41. PMID: 15308552.
      View in: PubMed
    295. Ghazalpour A, Doss S, Yang X, Aten J, Toomey EM, Van Nas A, Wang S, Drake TA, Lusis A. Thematic review series: The pathogenesis of atherosclerosis. Toward a biological network for atherosclerosis. J Lipid Res. 2004 Oct; 45(10):1793-805. PMID: 15292376.
      View in: PubMed
    296. Donnelly KL, Margosian MR, Sheth SS, Lusis A, Parks EJ. Increased lipogenesis and fatty acid reesterification contribute to hepatic triacylglycerol stores in hyperlipidemic Txnip-/- mice. J Nutr. 2004 Jun; 134(6):1475-80. PMID: 15173414.
      View in: PubMed
    297. Shi W, Wang X, Wong J, Hedrick CC, Wong H, Castellani LW, Lusis A. Effect of macrophage-derived apolipoprotein E on hyperlipidemia and atherosclerosis of LDLR-deficient mice. Biochem Biophys Res Commun. 2004 Apr 23; 317(1):223-9. PMID: 15047172.
      View in: PubMed
    298. Navab M, Ananthramaiah GM, Reddy ST, Van Lenten BJ, Ansell BJ, Fonarow GC, Vahabzadeh K, Hama S, Hough G, Kamranpour N, Berliner JA, Lusis A, Fogelman AM. The oxidation hypothesis of atherogenesis: the role of oxidized phospholipids and HDL. J Lipid Res. 2004 Jun; 45(6):993-1007. PMID: 15060092.
      View in: PubMed
    299. Hui TY, Sheth SS, Diffley JM, Potter DW, Lusis A, Attie AD, Davis RA. Mice lacking thioredoxin-interacting protein provide evidence linking cellular redox state to appropriate response to nutritional signals. J Biol Chem. 2004 Jun 04; 279(23):24387-93. PMID: 15047687.
      View in: PubMed
    300. Brown MD, Jin L, Jien ML, Matsumoto AH, Helm GA, Lusis A, Frank JS, Shi W. Lipid retention in the arterial wall of two mouse strains with different atherosclerosis susceptibility. J Lipid Res. 2004 Jun; 45(6):1155-61. PMID: 15105414.
      View in: PubMed
    301. Welch CL, Bretschger S, Wen PZ, Mehrabian M, Latib N, Fruchart-Najib J, Fruchart JC, Myrick C, Lusis A. Novel QTLs for HDL levels identified in mice by controlling for Apoa2 allelic effects: confirmation of a chromosome 6 locus in a congenic strain. Physiol Genomics. 2004 Mar 12; 17(1):48-59. PMID: 14722362.
      View in: PubMed
    302. Mar R, Pajukanta P, Allayee H, Groenendijk M, Dallinga-Thie G, Krauss RM, Sinsheimer JS, Cantor RM, de Bruin TW, Lusis A. Association of the APOLIPOPROTEIN A1/C3/A4/A5 gene cluster with triglyceride levels and LDL particle size in familial combined hyperlipidemia. Circ Res. 2004 Apr 16; 94(7):993-9. PMID: 15001527.
      View in: PubMed
    303. Liu D, Singh RP, Khan AH, Lusis A, Davis RC, Smith DJ. Mapping behavioral traits by use of genome-tagged mice. Am J Geriatr Psychiatry. 2004 Mar-Apr; 12(2):158-65. PMID: 15010345.
      View in: PubMed
    304. Pajukanta P, Lilja HE, Sinsheimer JS, Cantor RM, Lusis A, Gentile M, Duan XJ, Soro-Paavonen A, Naukkarinen J, Saarela J, Laakso M, Ehnholm C, Taskinen MR, Peltonen L. Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1). Nat Genet. 2004 Apr; 36(4):371-6. PMID: 14991056.
      View in: PubMed
    305. Estrada-Smith D, Castellani LW, Wong H, Wen PZ, Chui A, Lusis A, Davis RC. Dissection of multigenic obesity traits in congenic mouse strains. Mamm Genome. 2004 Jan; 15(1):14-22. PMID: 14727138.
      View in: PubMed
    306. Dwyer JH, Allayee H, Dwyer KM, Fan J, Wu H, Mar R, Lusis A, Mehrabian M. Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis. N Engl J Med. 2004 Jan 01; 350(1):29-37. PMID: 14702425.
      View in: PubMed
    307. Lusis A, Mar R, Pajukanta P. Genetics of atherosclerosis. Annu Rev Genomics Hum Genet. 2004; 5:189-218. PMID: 15485348.
      View in: PubMed
    308. MacLellan WR, Lusis A. Dilated cardiomyopathy: learning to live with yourself. Nat Med. 2003 Dec; 9(12):1455-6. PMID: 14647516.
      View in: PubMed
    309. Liu D, Singh RP, Khan AH, Bhavsar K, Lusis A, Davis RC, Smith DJ. Identifying loci for behavioral traits using genome-tagged mice. J Neurosci Res. 2003 Nov 15; 74(4):562-9. PMID: 14598300.
      View in: PubMed
    310. Lusis A. Genetic factors in cardiovascular disease. 10 questions. Trends Cardiovasc Med. 2003 Nov; 13(8):309-16. PMID: 14596945.
      View in: PubMed
    311. Allayee H, Ghazalpour A, Lusis A. Using mice to dissect genetic factors in atherosclerosis. Arterioscler Thromb Vasc Biol. 2003 Sep 01; 23(9):1501-9. PMID: 12920046.
      View in: PubMed
    312. Shi W, Brown MD, Wang X, Wong J, Kallmes DF, Matsumoto AH, Helm GA, Drake TA, Lusis A. Genetic backgrounds but not sizes of atherosclerotic lesions determine medial destruction in the aortic root of apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol. 2003 Oct 01; 23(10):1901-6. PMID: 12920047.
      View in: PubMed
    313. Araujo JA, Meng L, Tward AD, Hancock WW, Zhai Y, Lee A, Ishikawa K, Iyer S, Buelow R, Busuttil RW, Shih DM, Lusis A, Kupiec-Weglinski JW. Systemic rather than local heme oxygenase-1 overexpression improves cardiac allograft outcomes in a new transgenic mouse. J Immunol. 2003 Aug 01; 171(3):1572-80. PMID: 12874251.
      View in: PubMed
    314. Krass KL, Colinayo V, Ghazalpour A, Vinters HV, Lusis A, Drake TA. Genetic loci contributing to age-related hippocampal lesions in mice. Neurobiol Dis. 2003 Jul; 13(2):102-8. PMID: 12828934.
      View in: PubMed
    315. Colinayo VV, Qiao JH, Wang X, Krass KL, Schadt E, Lusis A, Drake TA. Genetic loci for diet-induced atherosclerotic lesions and plasma lipids in mice. Mamm Genome. 2003 Jul; 14(7):464-71. PMID: 12925895.
      View in: PubMed
    316. Cole TB, Jampsa RL, Walter BJ, Arndt TL, Richter RJ, Shih DM, Tward A, Lusis A, Jack RM, Costa LG, Furlong CE. Expression of human paraoxonase (PON1) during development. Pharmacogenetics. 2003 Jun; 13(6):357-64. PMID: 12777966.
      View in: PubMed
    317. Allayee H, Castellani LW, Cantor RM, de Bruin TW, Lusis A. Biochemical and genetic association of plasma apolipoprotein A-II levels with familial combined hyperlipidemia. Circ Res. 2003 Jun 13; 92(11):1262-7. PMID: 12738753.
      View in: PubMed
    318. Schadt EE, Monks SA, Drake TA, Lusis A, Che N, Colinayo V, Ruff TG, Milligan SB, Lamb JR, Cavet G, Linsley PS, Mao M, Stoughton RB, Friend SH. Genetics of gene expression surveyed in maize, mouse and man. Nature. 2003 Mar 20; 422(6929):297-302. PMID: 12646919.
      View in: PubMed
    319. Pajukanta P, Allayee H, Krass KL, Kuraishy A, Soro A, Lilja HE, Mar R, Taskinen MR, Nuotio I, Laakso M, Rotter JI, de Bruin TW, Cantor RM, Lusis A, Peltonen L. Combined analysis of genome scans of dutch and finnish families reveals a susceptibility locus for high-density lipoprotein cholesterol on chromosome 16q. Am J Hum Genet. 2003 Apr; 72(4):903-17. PMID: 12638083; PMCID: PMC1180353.
    320. Nishimura I, Drake TA, Lusis A, Lyons KM, Nadeau JH, Zernik J. ENU large-scale mutagenesis and quantitative trait linkage (QTL) analysis in mice: novel technologies for searching polygenetic determinants of craniofacial abnormalities. Crit Rev Oral Biol Med. 2003; 14(5):320-30. PMID: 14530301.
      View in: PubMed
    321. Attie AD, Krauss RM, Gray-Keller MP, Brownlie A, Miyazaki M, Kastelein JJ, Lusis A, Stalenhoef AF, Stoehr JP, Hayden MR, Ntambi JM. Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia. J Lipid Res. 2002 Nov; 43(11):1899-907. PMID: 12401889.
      View in: PubMed
    322. Smith DJ, Lusis A. The allelic structure of common disease. Hum Mol Genet. 2002 Oct 01; 11(20):2455-61. PMID: 12351581.
      View in: PubMed
    323. Smith JB, Wadleigh DJ, Xia YR, Mar RA, Herschman HR, Lusis A. Cloning and genomic localization of the murine LPS-induced CXC chemokine (LIX) gene, Scyb5. Immunogenetics. 2002 Nov; 54(8):599-603. PMID: 12439624.
      View in: PubMed
    324. Tangirala RK, Bischoff ED, Joseph SB, Wagner BL, Walczak R, Laffitte BA, Daige CL, Thomas D, Heyman RA, Mangelsdorf DJ, Wang X, Lusis A, Tontonoz P, Schulman IG. Identification of macrophage liver X receptors as inhibitors of atherosclerosis. Proc Natl Acad Sci U S A. 2002 Sep 03; 99(18):11896-901. PMID: 12193651; PMCID: PMC129365.
    325. Mehrabian M, Allayee H, Wong J, Shi W, Wang XP, Shaposhnik Z, Funk CD, Lusis A, Shih W. Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice. Circ Res. 2002 Jul 26; 91(2):120-6. PMID: 12142344.
      View in: PubMed
    326. Tward A, Xia YR, Wang XP, Shi YS, Park C, Castellani LW, Lusis A, Shih DM. Decreased atherosclerotic lesion formation in human serum paraoxonase transgenic mice. Circulation. 2002 Jul 23; 106(4):484-90. PMID: 12135950.
      View in: PubMed
    327. Eiserich JP, Baldus S, Brennan ML, Ma W, Zhang C, Tousson A, Castro L, Lusis A, Nauseef WM, White CR, Freeman BA. Myeloperoxidase, a leukocyte-derived vascular NO oxidase. Science. 2002 Jun 28; 296(5577):2391-4. PMID: 12089442.
      View in: PubMed
    328. Colinayo VV, Qiao JH, Demant P, Krass K, Lusis A, Drake TA. Genetic characterization of the Dyscalc locus. Mamm Genome. 2002 Jun; 13(6):283-8. PMID: 12115029.
      View in: PubMed
    329. Joseph SB, McKilligin E, Pei L, Watson MA, Collins AR, Laffitte BA, Chen M, Noh G, Goodman J, Hagger GN, Tran J, Tippin TK, Wang X, Lusis A, Hsueh WA, Law RE, Collins JL, Willson TM, Tontonoz P. Synthetic LXR ligand inhibits the development of atherosclerosis in mice. Proc Natl Acad Sci U S A. 2002 May 28; 99(11):7604-9. PMID: 12032330; PMCID: PMC124297.
    330. Allayee H, Krass KL, Pajukanta P, Cantor RM, van der Kallen CJ, Mar R, Rotter JI, de Bruin TW, Peltonen L, Lusis A. Locus for elevated apolipoprotein B levels on chromosome 1p31 in families with familial combined hyperlipidemia. Circ Res. 2002 May 03; 90(8):926-31. PMID: 11988495.
      View in: PubMed
    331. Shi W, Wang X, Shih DM, Laubach VE, Navab M, Lusis A. Paradoxical reduction of fatty streak formation in mice lacking endothelial nitric oxide synthase. Circulation. 2002 Apr 30; 105(17):2078-82. PMID: 11980688.
      View in: PubMed
    332. Shi W, Wang X, Tangchitpiyanond K, Wong J, Shi Y, Lusis A. Atherosclerosis in C3H/HeJ mice reconstituted with apolipoprotein E-null bone marrow. Arterioscler Thromb Vasc Biol. 2002 Apr 01; 22(4):650-5. PMID: 11950705.
      View in: PubMed
    333. Gukovskaya AS, Vaquero E, Zaninovic V, Gorelick FS, Lusis A, Brennan ML, Holland S, Pandol SJ. Neutrophils and NADPH oxidase mediate intrapancreatic trypsin activation in murine experimental acute pancreatitis. Gastroenterology. 2002 Apr; 122(4):974-84. PMID: 11910350.
      View in: PubMed
    334. Sheth SS, Deluna A, Allayee H, Lusis A. Understanding atherosclerosis through mouse genetics. Curr Opin Lipidol. 2002 Apr; 13(2):181-9. PMID: 11891421.
      View in: PubMed
    335. Brennan ML, Wu W, Fu X, Shen Z, Song W, Frost H, Vadseth C, Narine L, Lenkiewicz E, Borchers MT, Lusis A, Lee JJ, Lee NA, Abu-Soud HM, Ischiropoulos H, Hazen SL. A tale of two controversies: defining both the role of peroxidases in nitrotyrosine formation in vivo using eosinophil peroxidase and myeloperoxidase-deficient mice, and the nature of peroxidase-generated reactive nitrogen species. J Biol Chem. 2002 May 17; 277(20):17415-27. PMID: 11877405.
      View in: PubMed
    336. Miyake JH, Duong-Polk XT, Taylor JM, Du EZ, Castellani LW, Lusis A, Davis RA. Transgenic expression of cholesterol-7-alpha-hydroxylase prevents atherosclerosis in C57BL/6J mice. Arterioscler Thromb Vasc Biol. 2002 Jan; 22(1):121-6. PMID: 11788471.
      View in: PubMed
    337. Bodnar JS, Chatterjee A, Castellani LW, Ross DA, Ohmen J, Cavalcoli J, Wu C, Dains KM, Catanese J, Chu M, Sheth SS, Charugundla K, Demant P, West DB, de Jong P, Lusis A. Positional cloning of the combined hyperlipidemia gene Hyplip1. Nat Genet. 2002 Jan; 30(1):110-6. PMID: 11753387; PMCID: PMC2846781.
    338. Lusis A. Atherosclerosis. Nature. 2000 Sep 14; 407(6801):233-41. PMID: 11001066; PMCID: PMC2826222.