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Wu Anna

TitleDirector
InstitutionUniversity of California Los Angeles
DepartmentJCCC Cancer Molecular Imaging
AddressCNSI 4335 Crump Institute 570 Westwood Plaza
Los Angeles CA 90095
Phone(310) 794-5088
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    Other Positions
    TitleProfessor

    TitleFaculty

    TitleFaculty


    Collapse Research 
    Collapse Research Activities and Funding
    (PQC4) Imaging CD8 T Cells In Tumor Immunotherapy By Immunopet
    NIH/NCI R21CA190044Sep 17, 2014 - Aug 31, 2016
    Role: Principal Investigator
    In vivo imaging of T Cells using engineered antibodies and PET
    NIH/NIAID R21AI114255Jun 1, 2014 - May 31, 2016
    Role: Principal Investigator
    Multifunctional immunoPET tracers for pancreatic and prostate cancer
    NIH/NCI R01CA174294Apr 1, 2013 - Jul 31, 2021
    Role: Principal Investigator
    High-avidity multimeric cancer imaging agent
    NIH/NCI R21CA110523Aug 1, 2004 - Jul 31, 2007
    Role: Principal Investigator
    MOLECULAR BASIS OF METASTASIS
    NIH/NCI R01CA042365Jul 1, 1986 - Dec 31, 1989
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Zettlitz KA, Tavaré R, Tsai WK, Yamada RE, Ha NS, Collins J, van Dam RM, Timmerman JM, Wu AM. 18F-labeled anti-human CD20 cys-diabody for same-day immunoPET in a model of aggressive B cell lymphoma in human CD20 transgenic mice. Eur J Nucl Med Mol Imaging. 2018 Nov 19. PMID: 30456475.
      View in: PubMed
    2. Zhang M, Kobayashi N, Zettlitz KA, Kono EA, Yamashiro JM, Tsai WK, Jiang ZK, Tran CP, Wang C, Guan J, Wu AM, Reiter RE. Near-infrared-dye labeled anti-Prostate Stem Cell Antigen minibody enables real-time fluorescence imaging and targeted surgery in translational mouse models. Clin Cancer Res. 2018 Oct 09. PMID: 30301826.
      View in: PubMed
    3. Seo JW, Tavaré R, Mahakian LM, Silvestrini MT, Tam S, Ingham ES, Salazar FB, Borowsky AD, Wu AM, Ferrara KW. CD8+ T-cell density imaging with 64Cu-labeled cys-diabody informs immunotherapy protocols. Clin Cancer Res. 2018 Jul 02. PMID: 29967252.
      View in: PubMed
    4. Zettlitz KA, Tsai WK, Knowles SM, Kobayashi N, Donahue TR, Reiter RE, Wu AM. Dual-modality immunoPET and near-infrared fluorescence (NIRF) imaging of pancreatic cancer using an anti-prostate cancer stem cell antigen (PSCA) cys-diabody. J Nucl Med. 2018 Mar 30. PMID: 29602820.
      View in: PubMed
    5. Tsai WK, Wu AM. Aligning physics and physiology: Engineering antibodies for radionuclide delivery. J Labelled Comp Radiopharm. 2018 Mar 14. PMID: 29537104.
      View in: PubMed
    6. Freise AC, Zettlitz KA, Salazar FB, Tavaré R, Tsai WK, Hadjioannou A, Rozengurt N, Braun J, Wu AM. ImmunoPET in inflammatory bowel disease: Imaging CD4+ T cells in a murine model of colitis. J Nucl Med. 2018 Jan 11. PMID: 29326360.
      View in: PubMed
    7. Lu J, Liu X, Liao YP, Salazar F, Sun B, Jiang W, Chang CH, Jiang J, Wang X, Wu AM, Meng H, Nel AE. Nano-enabled pancreas cancer immunotherapy using immunogenic cell death and reversing immunosuppression. Nat Commun. 2017 Nov 27; 8(1):1811. PMID: 29180759.
      View in: PubMed
    8. Priceman SJ, Gerdts EA, Tilakawardane D, Kennewick KT, Murad JP, Park AK, Jeang B, Yamaguchi Y, Yang X, Urak R, Weng L, Chang WC, Wright S, Pal S, Reiter RE, Wu AM, Brown CE, Forman SJ. Co-stimulatory signaling determines tumor antigen sensitivity and persistence of CAR T cells targeting PSCA+ metastatic prostate cancer. Oncoimmunology. 2018; 7(2):e1380764. PMID: 29308300.
      View in: PubMed
    9. Orcutt KD, Adams GP, Wu AM, Silva MD, Harwell C, Hoppin J, Matsumura M, Kotsuma M, Greenberg J, Scott AM, Beckman RA. Molecular Simulation of Receptor Occupancy and Tumor Penetration of an Antibody and Smaller Scaffolds: Application to Molecular Imaging. Mol Imaging Biol. 2017 Oct; 19(5):656-664. PMID: 28213834.
      View in: PubMed
    10. Zettlitz KA, Tavaré R, Knowles SM, Steward KK, Timmerman JM, Wu AM. ImmunoPET of Malignant and Normal B Cells with 89Zr- and 124I-Labeled Obinutuzumab Antibody Fragments Reveals Differential CD20 Internalization In Vivo. Clin Cancer Res. 2017 Dec 01; 23(23):7242-7252. PMID: 28928164.
      View in: PubMed
    11. Cahan B, Leong L, Wagman L, Yamauchi D, Shibata S, Wilzcynski S, Williams LE, Yazaki P, Colcher D, Frankel P, Wu A, Raubitschek A, Shively J, Wong JYC. Phase I/II Trial of Anticarcinoembryonic Antigen Radioimmunotherapy, Gemcitabine, and Hepatic Arterial Infusion of Fluorodeoxyuridine Postresection of Liver Metastasis for Colorectal Carcinoma. Cancer Biother Radiopharm. 2017 Sep; 32(7):258-265. PMID: 28910150.
      View in: PubMed
    12. Shields AF, Jacobs PM, Sznol M, Graham MM, Germain RN, Lum LG, Jaffee EM, de Vries EGE, Nimmagadda S, Van den Abbeele AD, Leung DK, Wu AM, Sharon E, Shankar LK. Immune Modulation Therapy and Imaging: Workshop Report. J Nucl Med. 2018 Mar; 59(3):410-417. PMID: 28818991.
      View in: PubMed
    13. Freise AC, Zettlitz KA, Salazar FB, Lu X, Tavaré R, Wu AM. ImmunoPET Imaging of Murine CD4+ T Cells Using Anti-CD4 Cys-Diabody: Effects of Protein Dose on T Cell Function and Imaging. Mol Imaging Biol. 2017 Aug; 19(4):599-609. PMID: 27966069.
      View in: PubMed
    14. Mayle KM, Dern KR, Wong VK, Chen KY, Sung S, Ding K, Rodriguez AR, Knowles S, Taylor Z, Zhou ZH, Grundfest WS, Wu AM, Deming TJ, Kamei DT. Engineering A11 Minibody-Conjugated, Polypeptide-Based Gold Nanoshells for Prostate Stem Cell Antigen (PSCA)-Targeted Photothermal Therapy. SLAS Technol. 2017 Feb; 22(1):26-35. PMID: 27659802.
      View in: PubMed
    15. Park SM, Lee JY, Hong S, Lee SH, Dimov IK, Lee H, Suh S, Pan Q, Li K, Wu AM, Mumenthaler SM, Mallick P, Lee LP. Dual transcript and protein quantification in a massive single cell array. Lab Chip. 2016 10 07; 16(19):3682-8. PMID: 27546183.
      View in: PubMed
    16. Pandit-Taskar N, O'Donoghue JA, Ruan S, Lyashchenko SK, Carrasquillo JA, Heller G, Martinez DF, Cheal SM, Lewis JS, Fleisher M, Keppler JS, Reiter RE, Wu AM, Weber WA, Scher HI, Larson SM, Morris MJ. First-in-Human Imaging with 89Zr-Df-IAB2M Anti-PSMA Minibody in Patients with Metastatic Prostate Cancer: Pharmacokinetics, Biodistribution, Dosimetry, and Lesion Uptake. J Nucl Med. 2016 Dec; 57(12):1858-1864. PMID: 27516450.
      View in: PubMed
    17. Tavaré R, Escuin-Ordinas H, Mok S, McCracken MN, Zettlitz KA, Salazar FB, Witte ON, Ribas A, Wu AM. An Effective Immuno-PET Imaging Method to Monitor CD8-Dependent Responses to Immunotherapy. Cancer Res. 2016 Jan 01; 76(1):73-82. PMID: 26573799; PMCID: PMC4703530 [Available on 01/01/17].
    18. Sonn GA, Behesnilian AS, Jiang ZK, Zettlitz KA, Lepin EJ, Bentolila LA, Knowles SM, Lawrence D, Wu AM, Reiter RE. Fluorescent Image-Guided Surgery with an Anti-Prostate Stem Cell Antigen (PSCA) Diabody Enables Targeted Resection of Mouse Prostate Cancer Xenografts in Real Time. Clin Cancer Res. 2016 Mar 15; 22(6):1403-12. PMID: 26490315; PMCID: PMC4794340 [Available on 03/15/17].
    19. White JB, Boucher DL, Zettlitz KA, Wu AM, Sutcliffe JL. Development and characterization of an avß6-specific diabody and a disulfide-stabilized avß6-specific cys-diabody. Nucl Med Biol. 2015 Dec; 42(12):945-57. PMID: 26341848.
      View in: PubMed
    20. Li K, Zettlitz KA, Lipianskaya J, Zhou Y, Marks JD, Mallick P, Reiter RE, Wu AM. A fully human scFv phage display library for rapid antibody fragment reformatting. Protein Eng Des Sel. 2015 Oct; 28(10):307-16. PMID: 25991864; PMCID: PMC4607741 [Available on 10/01/16].
    21. Tavaré R, McCracken MN, Zettlitz KA, Salazar FB, Olafsen T, Witte ON, Wu AM. Immuno-PET of Murine T Cell Reconstitution Postadoptive Stem Cell Transplantation Using Anti-CD4 and Anti-CD8 Cys-Diabodies. J Nucl Med. 2015 Aug; 56(8):1258-64. PMID: 25952734; PMCID: PMC4859343.
    22. Freise AC, Wu AM. In vivo imaging with antibodies and engineered fragments. Mol Immunol. 2015 Oct; 67(2 Pt A):142-52. PMID: 25934435; PMCID: PMC4529772 [Available on 10/01/16].
    23. Davis SJ, Sheppard KE, Anglesio MS, George J, Traficante N, Fereday S, Intermaggio MP, Menon U, Gentry-Maharaj A, Lubinski J, Gronwald J, Pearce CL, Pike MC, Wu A, Kommoss S, Pfisterer J, du Bois A, Hilpert F, Ramus SJ, Bowtell DD, Huntsman DG, Pearson RB, Simpson KJ, Campbell IG, Gorringe KL. Enhanced GAB2 Expression Is Associated with Improved Survival in High-Grade Serous Ovarian Cancer and Sensitivity to PI3K Inhibition. Mol Cancer Ther. 2015 Jun; 14(6):1495-503. PMID: 25852062.
      View in: PubMed
    24. Örbom A, Ahlstedt J, Serén T, Auterinen I, Kotiluoto P, Hauge H, Östlund K, Olafsen T, Wu AM, Dahlbom M, Strand SE. Characterization of a double-sided silicon strip detector autoradiography system. Med Phys. 2015 Feb; 42(2):575-84. PMID: 25652478.
      View in: PubMed
    25. Watanabe R, Hanaoka H, Sato K, Nagaya T, Harada T, Mitsunaga M, Kim I, Paik CH, Wu AM, Choyke PL, Kobayashi H. Photoimmunotherapy targeting prostate-specific membrane antigen: are antibody fragments as effective as antibodies? J Nucl Med. 2015 Jan; 56(1):140-4. PMID: 25500827.
      View in: PubMed
    26. Knowles SM, Tavaré R, Zettlitz KA, Rochefort MM, Salazar FB, Jiang ZK, Reiter RE, Wu AM. Applications of immunoPET: using 124I-anti-PSCA A11 minibody for imaging disease progression and response to therapy in mouse xenograft models of prostate cancer. Clin Cancer Res. 2014 Dec 15; 20(24):6367-78. PMID: 25326233; PMCID: PMC4268335.
    27. Rochefort MM, Girgis MD, Knowles SM, Ankeny JS, Salazar F, Wu AM, Tomlinson JS. A mutated anti-CA19-9 scFv-Fc for positron emission tomography of human pancreatic cancer xenografts. Mol Imaging Biol. 2014 Oct; 16(5):721-9. PMID: 24691872; PMCID: PMC4334371.
    28. Li K, Tavaré R, Zettlitz KA, Mumenthaler SM, Mallick P, Zhou Y, Marks JD, Wu AM. Anti-MET immunoPET for non-small cell lung cancer using novel fully human antibody fragments. Mol Cancer Ther. 2014 Nov; 13(11):2607-17. PMID: 25143449; PMCID: PMC4221648.
    29. Tavaré R, Wu WH, Zettlitz KA, Salazar FB, McCabe KE, Marks JD, Wu AM. Enhanced immunoPET of ALCAM-positive colorectal carcinoma using site-specific 64Cu-DOTA conjugation. Protein Eng Des Sel. 2014 Oct; 27(10):317-24. PMID: 25095796; PMCID: PMC4191443.
    30. Wilks MQ, Knowles SM, Wu AM, Huang SC. Improved modeling of in vivo kinetics of slowly diffusing radiotracers for tumor imaging. J Nucl Med. 2014 Sep; 55(9):1539-44. PMID: 24994929; PMCID: PMC4334373.
    31. Viola-Villegas NT, Sevak KK, Carlin SD, Doran MG, Evans HW, Bartlett DW, Wu AM, Lewis JS. Noninvasive Imaging of PSMA in prostate tumors with (89)Zr-Labeled huJ591 engineered antibody fragments: the faster alternatives. Mol Pharm. 2014 Nov 03; 11(11):3965-73. PMID: 24779727; PMCID: PMC4224519.
    32. Knowles SM, Zettlitz KA, Tavaré R, Rochefort MM, Salazar FB, Stout DB, Yazaki PJ, Reiter RE, Wu AM. Quantitative immunoPET of prostate cancer xenografts with 89Zr- and 124I-labeled anti-PSCA A11 minibody. J Nucl Med. 2014 Mar; 55(3):452-9. PMID: 24504052; PMCID: PMC4052832.
    33. Williams LE, Wu AM, Kenanova VE, Olafsen T, Yazaki PJ. Numerical comparison of iodine-based and indium-based antibody biodistributions. Cancer Biother Radiopharm. 2014 Apr; 29(3):91-8. PMID: 24443889.
      View in: PubMed
    34. Watanabe R, Sato K, Hanaoka H, Harada T, Nakajima T, Kim I, Paik CH, Wu AM, Choyke PL, Kobayashi H. Minibody-indocyanine green based activatable optical imaging probes: the role of short polyethylene glycol linkers. ACS Med Chem Lett. 2014 Apr 10; 5(4):411-5. PMID: 24900850; PMCID: PMC4027604.
    35. Tavaré R, McCracken MN, Zettlitz KA, Knowles SM, Salazar FB, Olafsen T, Witte ON, Wu AM. Engineered antibody fragments for immuno-PET imaging of endogenous CD8+ T cells in vivo. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):1108-13. PMID: 24390540; PMCID: PMC3903195.
    36. Sano K, Nakajima T, Ali T, Bartlett DW, Wu AM, Kim I, Paik CH, Choyke PL, Kobayashi H. Activatable fluorescent cys-diabody conjugated with indocyanine green derivative: consideration of fluorescent catabolite kinetics on molecular imaging. J Biomed Opt. 2013 Oct; 18(10):101304. PMID: 23752742; PMCID: PMC3677842.
    37. Wu AM. Engineered antibodies for molecular imaging of cancer. Methods. 2014 Jan 01; 65(1):139-47. PMID: 24091005; PMCID: PMC3947235.
    38. Widney DP, Olafsen T, Wu AM, Kitchen CM, Said JW, Smith JB, Peña G, Magpantay LI, Penichet ML, Martinez-Maza O. Levels of murine, but not human, CXCL13 are greatly elevated in NOD-SCID mice bearing the AIDS-associated Burkitt lymphoma cell line, 2F7. PLoS One. 2013; 8(8):e72414. PMID: 23936541; PMCID: PMC3732224.
    39. Girgis MD, Federman N, Rochefort MM, McCabe KE, Wu AM, Nagy JO, Denny C, Tomlinson JS. An engineered anti-CA19-9 cys-diabody for positron emission tomography imaging of pancreatic cancer and targeting of polymerized liposomal nanoparticles. J Surg Res. 2013 Nov; 185(1):45-55. PMID: 23827791.
      View in: PubMed
    40. Choe UJ, Rodriguez AR, Lee BS, Knowles SM, Wu AM, Deming TJ, Kamei DT. Endocytosis and intracellular trafficking properties of transferrin-conjugated block copolypeptide vesicles. Biomacromolecules. 2013 May 13; 14(5):1458-64. PMID: 23581747; PMCID: PMC4022909.
    41. Fu M, Brewer S, Olafsen T, Wu AM, Gordon LK, Said J, Braun J, Wadehra M. Positron emission tomography imaging of endometrial cancer using engineered anti-EMP2 antibody fragments. Mol Imaging Biol. 2013 Feb; 15(1):68-78. PMID: 22585360; PMCID: PMC3553410.
    42. Knowles SM, Wu AM. Advances in immuno-positron emission tomography: antibodies for molecular imaging in oncology. J Clin Oncol. 2012 Nov 01; 30(31):3884-92. PMID: 22987087; PMCID: PMC3478579.
    43. Federman N, Chan J, Nagy JO, Landaw EM, McCabe K, Wu AM, Triche T, Kang H, Liu B, Marks JD, Denny CT. Enhanced growth inhibition of osteosarcoma by cytotoxic polymerized liposomal nanoparticles targeting the alcam cell surface receptor. Sarcoma. 2012; 2012:126906. PMID: 23024593; PMCID: PMC3447386.
    44. McCabe KE, Liu B, Marks JD, Tomlinson JS, Wu H, Wu AM. An engineered cysteine-modified diabody for imaging activated leukocyte cell adhesion molecule (ALCAM)-positive tumors. Mol Imaging Biol. 2012 Jun; 14(3):336-47. PMID: 21630083; PMCID: PMC3227780.
    45. Andersen JT, Foss S, Kenanova VE, Olafsen T, Leikfoss IS, Roopenian DC, Wu AM, Sandlie I. Anti-carcinoembryonic antigen single-chain variable fragment antibody variants bind mouse and human neonatal Fc receptor with different affinities that reveal distinct cross-species differences in serum half-life. J Biol Chem. 2012 Jun 29; 287(27):22927-37. PMID: 22570488; PMCID: PMC3391105.
    46. Olafsen T, Sirk SJ, Olma S, Shen CK, Wu AM. ImmunoPET using engineered antibody fragments: fluorine-18 labeled diabodies for same-day imaging. Tumour Biol. 2012 Jun; 33(3):669-77. PMID: 22392499.
      View in: PubMed
    47. Girgis MD, Olafsen T, Kenanova V, McCabe KE, Wu AM, Tomlinson JS. Targeting CEA in Pancreas Cancer Xenografts with a Mutated scFv-Fc Antibody Fragment. EJNMMI Res. 2011 Nov 07; 1(1):24. PMID: 22214289; PMCID: PMC3251041.
    48. Girgis MD, Olafsen T, Kenanova V, McCabe KE, Wu AM, Tomlinson JS. CA19-9 as a Potential Target for Radiolabeled Antibody-Based Positron Emission Tomography of Pancreas Cancer. Int J Mol Imaging. 2011; 2011:834515. PMID: 21912743; PMCID: PMC3168788.
    49. Liu K, Wang MW, Lin WY, Phung DL, Girgis MD, Wu AM, Tomlinson JS, Shen CK. Molecular Imaging Probe Development using Microfluidics. Curr Org Synth. 2011 Aug 01; 8(4):473-487. PMID: 22977436.
      View in: PubMed
    50. Olafsen T, Elgqvist J, Wu AM. Protein targeting constructs in alpha therapy. Curr Radiopharm. 2011 Jul; 4(3):197-213. PMID: 22201709.
      View in: PubMed
    51. Liu K, Lepin EJ, Wang MW, Guo F, Lin WY, Chen YC, Sirk SJ, Olma S, Phelps ME, Zhao XZ, Tseng HR, Michael van Dam R, Wu AM, Shen CK. Microfluidic-based 18F-labeling of biomolecules for immuno-positron emission tomography. Mol Imaging. 2011 Jun; 10(3):168-76, 1-7. PMID: 21496447; PMCID: PMC3163899.
    52. Barat B, Kenanova VE, Olafsen T, Wu AM. Evaluation of two internalizing carcinoembryonic antigen reporter genes for molecular imaging. Mol Imaging Biol. 2011 Jun; 13(3):526-535. PMID: 20628903; PMCID: PMC2992604.
    53. Morizono K, Xie Y, Olafsen T, Lee B, Dasgupta A, Wu AM, Chen IS. The soluble serum protein Gas6 bridges virion envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry. Cell Host Microbe. 2011 Apr 21; 9(4):286-98. PMID: 21501828; PMCID: PMC3095825.
    54. Girgis MD, Kenanova V, Olafsen T, McCabe KE, Wu AM, Tomlinson JS. Anti-CA19-9 diabody as a PET imaging probe for pancreas cancer. J Surg Res. 2011 Oct; 170(2):169-78. PMID: 21601881.
      View in: PubMed
    55. Olafsen T, Young SG, Davies BS, Beigneux AP, Kenanova VE, Voss C, Young G, Wong KP, Barnes RH, Tu Y, Weinstein MM, Nobumori C, Huang SC, Goldberg IJ, Bensadoun A, Wu AM, Fong LG. Unexpected expression pattern for glycosylphosphatidylinositol-anchored HDL-binding protein 1 (GPIHBP1) in mouse tissues revealed by positron emission tomography scanning. J Biol Chem. 2010 Dec 10; 285(50):39239-48. PMID: 20889497; PMCID: PMC2998116.
    56. Kenanova VE, Olafsen T, Salazar FB, Williams LE, Knowles S, Wu AM. Tuning the serum persistence of human serum albumin domain III:diabody fusion proteins. Protein Eng Des Sel. 2010 Oct; 23(10):789-98. PMID: 20802234; PMCID: PMC2935312.
    57. Wong JY, Raubitschek A, Yamauchi D, Williams LE, Wu AM, Yazaki P, Shively JE, Colcher D, Somlo G. A pretherapy biodistribution and dosimetry study of indium-111-radiolabeled trastuzumab in patients with human epidermal growth factor receptor 2-overexpressing breast cancer. Cancer Biother Radiopharm. 2010 Aug; 25(4):387-94. PMID: 20707718; PMCID: PMC2958439.
    58. McCabe KE, Wu AM. Positive progress in immunoPET--not just a coincidence. Cancer Biother Radiopharm. 2010 Jun; 25(3):253-61. PMID: 20578830; PMCID: PMC2936262.
    59. Olafsen T, Wu AM. Antibody vectors for imaging. Semin Nucl Med. 2010 May; 40(3):167-81. PMID: 20350626; PMCID: PMC2853948.
    60. Aweda TA, Beck HE, Wu AM, Wei LH, Weber WA, Meares CF. Rates and equilibria for probe capture by an antibody with infinite affinity. Bioconjug Chem. 2010 Apr 21; 21(4):784-91. PMID: 20361788; PMCID: PMC2862285.
    61. Lepin EJ, Leyton JV, Zhou Y, Olafsen T, Salazar FB, McCabe KE, Hahm S, Marks JD, Reiter RE, Wu AM. An affinity matured minibody for PET imaging of prostate stem cell antigen (PSCA)-expressing tumors. Eur J Nucl Med Mol Imaging. 2010 Aug; 37(8):1529-38. PMID: 20354850; PMCID: PMC2903645.
    62. Sherman DJ, Kenanova VE, Lepin EJ, McCabe KE, Kamei K, Ohashi M, Wang S, Tseng HR, Wu AM, Behrenbruch CP. A differential cell capture assay for evaluating antibody interactions with cell surface targets. Anal Biochem. 2010 Jun 15; 401(2):173-81. PMID: 20178770; PMCID: PMC4485450.
    63. Gagnon P, Cheung CW, Lepin EJ, Wu AM, Sherman MA, Raubitschek AA, Yazaki PJ. Minibodies and Multimodal Chromatography Methods: A Convergence of Challenge and Opportunity. Bioprocess Int. 2010 Feb; 8(2):26-35. PMID: 21984873.
      View in: PubMed
    64. Olafsen T, Sirk SJ, Betting DJ, Kenanova VE, Bauer KB, Ladno W, Raubitschek AA, Timmerman JM, Wu AM. ImmunoPET imaging of B-cell lymphoma using 124I-anti-CD20 scFv dimers (diabodies). Protein Eng Des Sel. 2010 Apr; 23(4):243-9. PMID: 20053640; PMCID: PMC2841542.
    65. Frank RT, Edmiston M, Kendall SE, Najbauer J, Cheung CW, Kassa T, Metz MZ, Kim SU, Glackin CA, Wu AM, Yazaki PJ, Aboody KS. Neural stem cells as a novel platform for tumor-specific delivery of therapeutic antibodies. PLoS One. 2009 Dec 15; 4(12):e8314. PMID: 20016813; PMCID: PMC2789379.
    66. Afshar S, Olafsen T, Wu AM, Morrison SL. Characterization of an engineered human purine nucleoside phosphorylase fused to an anti-her2/neu single chain Fv for use in ADEPT. J Exp Clin Cancer Res. 2009 Dec 03; 28:147. PMID: 19958550; PMCID: PMC2799393.
    67. Olafsen T, Betting D, Kenanova VE, Salazar FB, Clarke P, Said J, Raubitschek AA, Timmerman JM, Wu AM. Recombinant anti-CD20 antibody fragments for small-animal PET imaging of B-cell lymphomas. J Nucl Med. 2009 Sep; 50(9):1500-8. PMID: 19690034; PMCID: PMC2852538.
    68. Vaidyanathan G, Jestin E, Olafsen T, Wu AM, Zalutsky MR. Evaluation of an anti-p185(HER2) (scFv-C(H)2-C(H)3)2 fragment following radioiodination using two different residualizing labels: SGMIB and IB-Mal-D-GEEEK. Nucl Med Biol. 2009 Aug; 36(6):671-80. PMID: 19647173; PMCID: PMC2720881.
    69. Barat B, Sirk SJ, McCabe KE, Li J, Lepin EJ, Remenyi R, Koh AL, Olafsen T, Gambhir SS, Weiss S, Wu AM. Cys-diabody quantum dot conjugates (immunoQdots) for cancer marker detection. Bioconjug Chem. 2009 Aug 19; 20(8):1474-81. PMID: 19642689; PMCID: PMC2891877.
    70. Zheng C, Zhang Y, Liu Y, Wu A, Xia L, Zeng J, Liu J, Qiu G. Characterization and reconstitute of a [Fe4S4] adenosine 5'-phosphosulfate reductase from Acidithiobacillus ferrooxidans. Curr Microbiol. 2009 Jun; 58(6):586-92. PMID: 19225840.
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    71. Shimazaki K, Chan AM, Moniz RJ, Wadehra M, Nagy A, Coulam CP, Mareninov S, Lepin EM, Wu AM, Kelly KA, Braun J, Gordon LK. Blockade of epithelial membrane protein 2 (EMP2) abrogates infection of Chlamydia muridarum murine genital infection model. FEMS Immunol Med Microbiol. 2009 Mar; 55(2):240-9. PMID: 19159428; PMCID: PMC3321642.
    72. Schipper ML, Iyer G, Koh AL, Cheng Z, Ebenstein Y, Aharoni A, Keren S, Bentolila LA, Li J, Rao J, Chen X, Banin U, Wu AM, Sinclair R, Weiss S, Gambhir SS. Particle size, surface coating, and PEGylation influence the biodistribution of quantum dots in living mice. Small. 2009 Jan; 5(1):126-34. PMID: 19051182; PMCID: PMC3084659.
    73. Wu AM. Antibodies and antimatter: the resurgence of immuno-PET. J Nucl Med. 2009 Jan; 50(1):2-5. PMID: 19091888.
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    74. Sirk SJ, Olafsen T, Barat B, Bauer KB, Wu AM. Site-specific, thiol-mediated conjugation of fluorescent probes to cysteine-modified diabodies targeting CD20 or HER2. Bioconjug Chem. 2008 Dec; 19(12):2527-34. PMID: 19053310; PMCID: PMC2668938.
    75. Shimazaki K, Lepin EJ, Wei B, Nagy AK, Coulam CP, Mareninov S, Fu M, Wu AM, Marks JD, Braun J, Gordon LK, Wadehra M. Diabodies targeting epithelial membrane protein 2 reduce tumorigenicity of human endometrial cancer cell lines. Clin Cancer Res. 2008 Nov 15; 14(22):7367-77. PMID: 19010852; PMCID: PMC3109074.
    76. Leyton JV, Olafsen T, Lepin EJ, Hahm S, Bauer KB, Reiter RE, Wu AM. Humanized radioiodinated minibody for imaging of prostate stem cell antigen-expressing tumors. Clin Cancer Res. 2008 Nov 15; 14(22):7488-96. PMID: 19010866; PMCID: PMC2720761.
    77. Leyton JV, Olafsen T, Sherman MA, Bauer KB, Aghajanian P, Reiter RE, Wu AM. Engineered humanized diabodies for microPET imaging of prostate stem cell antigen-expressing tumors. Protein Eng Des Sel. 2009 Mar; 22(3):209-16. PMID: 18957406; PMCID: PMC2644405.
    78. Wei LH, Olafsen T, Radu C, Hildebrandt IJ, McCoy MR, Phelps ME, Meares C, Wu AM, Czernin J, Weber WA. Engineered antibody fragments with infinite affinity as reporter genes for PET imaging. J Nucl Med. 2008 Nov; 49(11):1828-35. PMID: 18927335.
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    79. Kenanova V, Barat B, Olafsen T, Chatziioannou A, Herschman HR, Braun J, Wu AM. Recombinant carcinoembryonic antigen as a reporter gene for molecular imaging. Eur J Nucl Med Mol Imaging. 2009 Jan; 36(1):104-14. PMID: 18719907; PMCID: PMC2803699.
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