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Aldave Anthony

TitleChief
InstitutionUniversity of California Los Angeles
DepartmentCornea and Uveitis
AddressBOX 957000 3-124 DSERC
Los Angeles CA 90095
Phone(310) 206-7202
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    Other Positions
    TitleProfessor


    Collapse Research 
    Collapse Research Activities and Funding
    Identification and Characterization of the Genetic Basis of PPCD
    NIH/NEI R01EY022082Dec 1, 2012 - Nov 30, 2017
    Role: Principal Investigator
    Cloning/Gene/Posterior Polymorphous corneal dystrophy
    NIH/NEI K08EY016079Sep 30, 2005 - Mar 29, 2012
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Driver TH, Aravena C, Duong HNV, Christenbury JG, Yu F, Basak SK, Aldave AJ. Outcomes of the Boston Type I Keratoprosthesis as the Primary Penetrating Corneal Procedure. Cornea. 2018 Aug 27. PMID: 30157053.
      View in: PubMed
    2. Terry MA, Aldave AJ, Szczotka-Flynn LB, Liang W, Ayala AR, Maguire MG, Croasdale C, Daoud YJ, Dunn SP, Hoover CK, Macsai MS, Mauger TF, Pramanik S, Rosenwasser GO, Rose-Nussbaumer J, Stulting RD, Sugar A, Tu EY, Verdier DD, Yoo SH, Lass JH. Donor, Recipient and Operative Factors Associated with Graft Success in the Cornea Preservation Time Study. Ophthalmology. 2018 Aug 08. PMID: 30098353.
      View in: PubMed
    3. Mathews PM, Lindsley K, Aldave AJ, Akpek EK. Etiology of Global Corneal Blindness and Current Practices of Corneal Transplantation: A Focused Review. Cornea. 2018 Jun 14. PMID: 29912039.
      View in: PubMed
    4. Mian SI, Aldave AJ, Tu EY, Ayres BD, Jeng BH, Macsai MS, Nordlund ML, Penta JG, Pramanik S, Szczotka-Flynn LB, Ayala AR, Liang W, Maguire MG, Lass JH. Incidence and Outcomes of Positive Donor Rim Cultures and Infections in the Cornea Preservation Time Study. Cornea. 2018 Jun 14. PMID: 29912040.
      View in: PubMed
    5. Vahedi F, Chung DD, Gee KM, Chuephanich P, Aldave AJ. Epithelial Recurrent Erosion Dystrophy Secondary to COL17A1 c.3156C>T Mutation in a Non-white Family. Cornea. 2018 Apr 26. PMID: 29708937.
      View in: PubMed
    6. Cervantes AE, Gee KM, Whiting MF, Frausto RF, Aldave AJ. Confirmation and refinement of the heterozygous deletion of the small leucine-rich proteoglycans associated with posterior amorphous corneal dystrophy. Ophthalmic Genet. 2018 Apr 19; 1-6. PMID: 29671669.
      View in: PubMed
    7. Dohlman CH, Cade F, Regatieri CV, Zhou C, Lei F, Crnej A, Harissi-Dagher M, Robert MC, Papaliodis GN, Chen D, Aquavella JV, Akpek EK, Aldave AJ, Sippel KC, D'Amico DJ, Dohlman JG, Fagerholm P, Wang L, Shen LQ, González-Andrades M, Chodosh J, Kenyon KR, Foster CS, Pineda R, Melki S, Colby KA, Ciolino JB, Vavvas DG, Kinoshita S, Dana R, Paschalis EI. Chemical Burns of the Eye: The Role of Retinal Injury and New Therapeutic Possibilities. Cornea. 2018 Feb; 37(2):248-251. PMID: 29135604.
      View in: PubMed
    8. Aravena C, Yu F, Aldave AJ. Long-Term Visual Outcomes, Complications, and Retention of the Boston Type I Keratoprosthesis. Cornea. 2018 Jan; 37(1):3-10. PMID: 28990994.
      View in: PubMed
    9. Song Y, Sun M, Wang N, Zhou X, Zhao J, Wang Q, Chen S, Deng Y, Qiu L, Chen Y, Aldave AJ, Zhang F. Prevalence of transforming growth factor ß-induced gene corneal dystrophies in Chinese refractive surgery candidates. J Cataract Refract Surg. 2017 Dec; 43(12):1489-1494. PMID: 29233738.
      View in: PubMed
    10. Rosenwasser GO, Szczotka-Flynn LB, Ayala AR, Liang W, Aldave AJ, Dunn SP, McCall T, Navarro LC, Pramanik S, Ross KW, Stulting RD, Terry MA, Tu EY, Verdier DD, Kollman C, Gal RL, Beck RW, Lass JH. Effect of Cornea Preservation Time on Success of Descemet Stripping Automated Endothelial Keratoplasty: A Randomized Clinical Trial. JAMA Ophthalmol. 2017 12 01; 135(12):1401-1409. PMID: 29127431.
      View in: PubMed
    11. Lass JH, Benetz BA, Verdier DD, Szczotka-Flynn LB, Ayala AR, Liang W, Aldave AJ, Dunn SP, McCall T, Mian SI, Navarro LC, Patel SV, Pramanik S, Rosenwasser GO, Ross KW, Terry MA, Kollman C, Gal RL, Beck RW. Corneal Endothelial Cell Loss 3 Years After Successful Descemet Stripping Automated Endothelial Keratoplasty in the Cornea Preservation Time Study: A Randomized Clinical Trial. JAMA Ophthalmol. 2017 12 01; 135(12):1394-1400. PMID: 29127432.
      View in: PubMed
    12. Zakharevich M, Kattan JM, Chen JL, Lin BR, Cervantes AE, Chung DD, Frausto RF, Aldave AJ. Elucidating the molecular basis of PPCD: Effects of decreased ZEB1 expression on corneal endothelial cell function. Mol Vis. 2017; 23:740-752. PMID: 29046608.
      View in: PubMed
    13. Magalhaes OA, Aldave AJ. Scleral Pneumatonometry in Penetrating Keratoplasty: A Clinical Study. Cornea. 2017 Oct; 36(10):1200-1205. PMID: 28777100.
      View in: PubMed
    14. Chung DD, Frausto RF, Lin BR, Hanser EM, Cohen Z, Aldave AJ. Transcriptomic Profiling of Posterior Polymorphous Corneal Dystrophy. Invest Ophthalmol Vis Sci. 2017 06 01; 58(7):3202-3214. PMID: 28654985.
      View in: PubMed
    15. Fry M, Aravena C, Yu F, Kattan J, Aldave AJ. Long-term outcomes of the Boston type I keratoprosthesis in eyes with previous herpes simplex virus keratitis. Br J Ophthalmol. 2018 01; 102(1):48-53. PMID: 28495905.
      View in: PubMed
    16. Alfawaz AM, Holland GN, Yu F, Margolis MS, Giaconi JA, Aldave AJ. Reply. Ophthalmology. 2017 Apr; 124(4):e44. PMID: 28335959.
      View in: PubMed
    17. Afshari NA, Igo RP, Morris NJ, Stambolian D, Sharma S, Pulagam VL, Dunn S, Stamler JF, Truitt BJ, Rimmler J, Kuot A, Croasdale CR, Qin X, Burdon KP, Riazuddin SA, Mills R, Klebe S, Minear MA, Zhao J, Balajonda E, Rosenwasser GO, Baratz KH, Mootha VV, Patel SV, Gregory SG, Bailey-Wilson JE, Price MO, Price FW, Craig JE, Fingert JH, Gottsch JD, Aldave AJ, Klintworth GK, Lass JH, Li YJ, Iyengar SK. Genome-wide association study identifies three novel loci in Fuchs endothelial corneal dystrophy. Nat Commun. 2017 Mar 30; 8:14898. PMID: 28358029.
      View in: PubMed
    18. Kattan JM, Serna-Ojeda JC, Sharma A, Kim EK, Ramirez-Miranda A, Cruz-Aguilar M, Cervantes AE, Frausto RF, Zenteno JC, Graue-Hernandez EO, Aldave AJ. Vortex Pattern of Corneal Deposits in Granular Corneal Dystrophy Associated With the p.(Arg555Trp) Mutation in TGFBI. Cornea. 2017 Feb; 36(2):210-216. PMID: 28060069.
      View in: PubMed
    19. Chung DD, Frausto RF, Cervantes AE, Gee KM, Zakharevich M, Hanser EM, Stone EM, Heon E, Aldave AJ. Confirmation of the OVOL2 Promoter Mutation c.-307T>C in Posterior Polymorphous Corneal Dystrophy 1. PLoS One. 2017; 12(1):e0169215. PMID: 28046031.
      View in: PubMed
    20. Lenis TL, Chiu SY, Law SK, Yu F, Aldave AJ. Safety of Concurrent Boston Type I Keratoprosthesis and Glaucoma Drainage Device Implantation. Ophthalmology. 2017 01; 124(1):12-19. PMID: 27614591.
      View in: PubMed
    21. Aravena C, Bozkurt TK, Yu F, Aldave AJ. Long-Term Outcomes of the Boston Type I Keratoprosthesis in the Management of Corneal Limbal Stem Cell Deficiency. Cornea. 2016 Sep; 35(9):1156-64. PMID: 27387566.
      View in: PubMed
    22. Kao L, Azimov R, Shao XM, Frausto RF, Abuladze N, Newman D, Aldave AJ, Kurtz I. Multifunctional ion transport properties of human SLC4A11: comparison of the SLC4A11-B and SLC4A11-C variants. Am J Physiol Cell Physiol. 2016 Nov 01; 311(5):C820-C830. PMID: 27581649.
      View in: PubMed
    23. Chung DW, Frausto RF, Chiu S, Lin BR, Aldave AJ. Investigating the Molecular Basis of PPCD3: Characterization of ZEB1 Regulation of COL4A3 Expression. Invest Ophthalmol Vis Sci. 2016 08 01; 57(10):4136-43. PMID: 27537263; PMCID: PMC4991021 [Available on 02/01/17].
    24. Ann LB, Abbouda A, Frausto RF, Huseynli S, Gupta K, Alió JL, Aldave AJ. Variant lattice corneal dystrophy associated with compound heterozygous mutations in the TGFBI gene. Br J Ophthalmol. 2017 04; 101(4):509-513. PMID: 27402970.
      View in: PubMed
    25. Le DJ, Chung DW, Frausto RF, Kim MJ, Aldave AJ. Identification of Potentially Pathogenic Variants in the Posterior Polymorphous Corneal Dystrophy 1 Locus. PLoS One. 2016; 11(6):e0158467. PMID: 27355326; PMCID: PMC4927100.
    26. Lin BR, Le DJ, Chen Y, Wang Q, Chung DD, Frausto RF, Croasdale C, Yee RW, Hejtmancik FJ, Aldave AJ. Whole Exome Sequencing and Segregation Analysis Confirms That a Mutation in COL17A1 Is the Cause of Epithelial Recurrent Erosion Dystrophy in a Large Dominant Pedigree Previously Mapped to Chromosome 10q23-q24. PLoS One. 2016; 11(6):e0157418. PMID: 27309958; PMCID: PMC4911149.
    27. Lin BR, Frausto RF, Vo RC, Chiu SY, Chen JL, Aldave AJ. Identification of the First De Novo UBIAD1 Gene Mutation Associated with Schnyder Corneal Dystrophy. J Ophthalmol. 2016; 2016:1968493. PMID: 27382485; PMCID: PMC4921136.
    28. Alfawaz AM, Holland GN, Yu F, Margolis MS, Giaconi JA, Aldave AJ. Corneal Endothelium in Patients with Anterior Uveitis. Ophthalmology. 2016 08; 123(8):1637-1645. PMID: 27262766.
      View in: PubMed
    29. Mannis TE, Mannis GN, Waterhouse EG, Aldave AJ, Rose-Nussbaumer J. Paraproteinemic keratopathy as the presenting sign of hematologic malignancy. Am J Hematol. 2016 Sep; 91(9):961-2. PMID: 26872417.
      View in: PubMed
    30. St Clair RM, Sharma A, Huang D, Yu F, Goldich Y, Rootman D, Yoo S, Cabot F, Jun J, Zhang L, Aldave AJ. Development of a nomogram for femtosecond laser astigmatic keratotomy for astigmatism after keratoplasty. J Cataract Refract Surg. 2016 Apr; 42(4):556-62. PMID: 27113878.
      View in: PubMed
    31. Dong PN, Han TN, Aldave AJ, Chau HT. Indications for and techniques of keratoplasty at Vietnam National Institute of Ophthalmology. Int J Ophthalmol. 2016; 9(3):379-83. PMID: 27158606; PMCID: PMC4844031.
    32. Chen JL, Lin BR, Gee KM, Gee JA, Chung DW, Frausto RF, Deng SX, Aldave AJ. Identification of presumed pathogenic KRT3 and KRT12 gene mutations associated with Meesmann corneal dystrophy. Mol Vis. 2015; 21:1378-86. PMID: 26788030; PMCID: PMC4704769.
    33. Ahmad S, Mathews PM, Lindsley K, Alkharashi M, Hwang FS, Ng SM, Aldave AJ, Akpek EK. Boston Type 1 Keratoprosthesis versus Repeat Donor Keratoplasty for Corneal Graft Failure: A Systematic Review and Meta-analysis. Ophthalmology. 2016 Jan; 123(1):165-77. PMID: 26545318.
      View in: PubMed
    34. Alexander JK, Basak SK, Padilla MD, Yu F, Aldave AJ. International Outcomes of the Boston Type I Keratoprosthesis in Stevens-Johnson Syndrome. Cornea. 2015 Nov; 34(11):1387-94. PMID: 26382898.
      View in: PubMed
    35. Ahmad S, Mathews PM, Srikumaran D, Aldave AJ, Lenis T, Aquavella JV, Hannush SB, Belin M, Akpek EK. Outcomes of Repeat Boston Type 1 Keratoprosthesis Implantation. Am J Ophthalmol. 2016 Jan; 161:181-7.e1. PMID: 26482467.
      View in: PubMed
    36. Vo RC, Chen JL, Sanchez PJ, Yu F, Aldave AJ. Long-Term Outcomes of Epithelial Debridement and Diamond Burr Polishing for Corneal Epithelial Irregularity and Recurrent Corneal Erosion. Cornea. 2015 Oct; 34(10):1259-65. PMID: 26203746.
      View in: PubMed
    37. Gee JA, Frausto RF, Chung DW, Tangmonkongvoragul C, Le DJ, Wang C, Han J, Aldave AJ. Identification of novel PIKFYVE gene mutations associated with Fleck corneal dystrophy. Mol Vis. 2015; 21:1093-100. PMID: 26396486; PMCID: PMC4575904.
    38. Frausto RF, Le DJ, Aldave AJ. Transcriptomic Analysis of Cultured Corneal Endothelial Cells as a Validation for Their Use in Cell Replacement Therapy. Cell Transplant. 2016; 25(6):1159-76. PMID: 26337789; PMCID: PMC4775465 [Available on 01/01/17].
    39. Tannan A, Vo RC, Chen JL, Yu F, Deng SX, Aldave AJ. Comparison of ACIOL Retention With IOL Exchange in Patients Undergoing Descemet Stripping Automated Endothelial Keratoplasty. Cornea. 2015 Sep; 34(9):1030-4. PMID: 26147836.
      View in: PubMed
    40. Milman T, Kao AA, Chu D, Gorski M, Steiner A, Simon CZ, Shih C, Aldave AJ, Eagle RC, Jakobiec FA, Udell I. Paraproteinemic Keratopathy: The Expanding Diversity of Clinical and Pathologic Manifestations. Ophthalmology. 2015 Sep; 122(9):1748-56. PMID: 26118999.
      View in: PubMed
    41. Lass JH, Szczotka-Flynn LB, Ayala AR, Benetz BA, Gal RL, Aldave AJ, Corrigan MM, Dunn SP, McCall TL, Pramanik S, Rosenwasser GO, Ross KW, Terry MA, Verdier DD. Cornea preservation time study: methods and potential impact on the cornea donor pool in the United States. Cornea. 2015 Jun; 34(6):601-8. PMID: 25850706; PMCID: PMC4426012.
    42. Weiss JS, Møller HU, Aldave AJ, Seitz B, Bredrup C, Kivelä T, Munier FL, Rapuano CJ, Nischal KK, Kim EK, Sutphin J, Busin M, Labbé A, Kenyon KR, Kinoshita S, Lisch W. IC3D classification of corneal dystrophies--edition 2. Cornea. 2015 Feb; 34(2):117-59. PMID: 25564336.
      View in: PubMed
    43. Rootman DB, Kim MJ, Aldave AJ, Douglas R, Hwang C, Goldberg R. Ocular surface, fornix, and eyelid rehabilitation in Boston type I keratoprosthesis patients with mucous membrane disease. Ophthalmic Plast Reconstr Surg. 2015 Jan-Feb; 31(1):43-9. PMID: 24911535.
      View in: PubMed
    44. Frausto RF, Wang C, Aldave AJ. Transcriptome analysis of the human corneal endothelium. Invest Ophthalmol Vis Sci. 2014 Nov 06; 55(12):7821-30. PMID: 25377225; PMCID: PMC4258927.
    45. Law SK, Huang JS, Nassiri N, Moghimi S, Nilforushan N, Parham A, Moossai J, Kim M, Caprioli J, Aldave AJ. Technique of combined glaucoma tube shunt and keratoprosthesis implantation. J Glaucoma. 2014 Oct-Nov; 23(8):501-7. PMID: 25275831.
      View in: PubMed
    46. Chung DW, Frausto RF, Ann LB, Jang MS, Aldave AJ. Functional impact of ZEB1 mutations associated with posterior polymorphous and Fuchs' endothelial corneal dystrophies. Invest Ophthalmol Vis Sci. 2014 Sep 04; 55(10):6159-66. PMID: 25190660; PMCID: PMC4184387.
    47. Vo RC, Stafeeva K, Aldave AJ, Stulting RD, Moore Q, Pflugfelder SC, Chungfat NC, Holsclaw DS, Margolis TP, Deng SX. Complications related to a cosmetic eye-whitening procedure. Am J Ophthalmol. 2014 Nov; 158(5):967-73. PMID: 25072832.
      View in: PubMed
    48. Srikumaran D, Munoz B, Aldave AJ, Aquavella JV, Hannush SB, Schultze R, Belin M, Akpek EK. Long-term outcomes of boston type 1 keratoprosthesis implantation: a retrospective multicenter cohort. Ophthalmology. 2014 Nov; 121(11):2159-64. PMID: 25017414.
      View in: PubMed
    49. Mitry D, Bhogal M, Patel AK, Lee BS, Chai SM, Price MO, Price FW, Jun AS, Aldave AJ, Mehta JS, Busin M, Allan BD. Descemet stripping automated endothelial keratoplasty after failed penetrating keratoplasty: survival, rejection risk, and visual outcome. JAMA Ophthalmol. 2014 Jun; 132(6):742-9. PMID: 24763830.
      View in: PubMed
    50. Jang MS, Roldan AN, Frausto RF, Aldave AJ. Posterior polymorphous corneal dystrophy 3 is associated with agenesis and hypoplasia of the corpus callosum. Vision Res. 2014 Jul; 100:88-92. PMID: 24780443; PMCID: PMC4074516.
    51. Kim MJ, Frausto RF, Rosenwasser GO, Bui T, Le DJ, Stone EM, Aldave AJ. Posterior amorphous corneal dystrophy is associated with a deletion of small leucine-rich proteoglycans on chromosome 12. PLoS One. 2014; 9(4):e95037. PMID: 24759697; PMCID: PMC3997350.
    52. Aldave AJ, Chen JL, Zaman AS, Deng SX, Yu F. Outcomes after DSEK in 101 eyes with previous trabeculectomy and tube shunt implantation. Cornea. 2014 Mar; 33(3):223-9. PMID: 24322807.
      View in: PubMed
    53. Bui T, Young JW, Frausto RF, Markello TC, Glasgow BJ, Aldave AJ. Hereditary Benign Intraepithelial Dyskeratosis: Report of a Case and Re-examination of the Evidence for Locus Heterogeneity. Ophthalmic Genet. 2016; 37(1):76-80. PMID: 24555743; PMCID: PMC4139474 [Available on 03/01/17].
    54. Bakhtiari P, Agarwal DR, Fernandez AA, Milman T, Glasgow B, Starr CE, Aldave AJ. Corneal keloid: report of natural history and outcome of surgical management in two cases. Cornea. 2013 Dec; 32(12):1621-4. PMID: 24113371.
      View in: PubMed
    55. Aldave AJ, Ann LB, Frausto RF, Nguyen CK, Yu F, Raber IM. Classification of posterior polymorphous corneal dystrophy as a corneal ectatic disorder following confirmation of associated significant corneal steepening. JAMA Ophthalmol. 2013 Dec; 131(12):1583-90. PMID: 24113819; PMCID: PMC3888803.
    56. Wells JA, Aldave AJ, Tsui I. Surgical technique: hand-over-hand retrieval of a posteriorly dislocated DSAEK graft in an eye with an iris reconstruction lens. Ophthalmic Surg Lasers Imaging Retina. 2013 Nov 01; 44(6):569-71. PMID: 24144176.
      View in: PubMed
    57. Stone EM, Aldave AJ, Drack AV, MacCumber MW, Sheffield VC, Traboulsi E, Weleber RG. Author reply: To PMID 22944025. Ophthalmology. 2013 Oct; 120(10):e73. PMID: 24090960.
      View in: PubMed
    58. Han J, Young JW, Frausto RF, Isenberg SJ, Aldave AJ. X-linked Megalocornea Associated with the Novel CHRDL1 Gene Mutation p.(Pro56Leu*8). Ophthalmic Genet. 2015 Jun; 36(2):145-8. PMID: 24073597; PMCID: PMC3968246.
    59. Hung C, Ayabe RI, Wang C, Frausto RF, Aldave AJ. Pre-Descemet corneal dystrophy and X-linked ichthyosis associated with deletion of Xp22.31 containing the STS gene. Cornea. 2013 Sep; 32(9):1283-7. PMID: 23807007; PMCID: PMC3740086.
    60. Aldave AJ, Han J, Frausto RF. Genetics of the corneal endothelial dystrophies: an evidence-based review. Clin Genet. 2013 Aug; 84(2):109-19. PMID: 23662738; PMCID: PMC3885339.
    61. Kim MJ, Yu F, Aldave AJ. Microbial keratitis after Boston type I keratoprosthesis implantation: incidence, organisms, risk factors, and outcomes. Ophthalmology. 2013 Nov; 120(11):2209-16. PMID: 23747162.
      View in: PubMed
    62. Li X, Bykhovskaya Y, Tang YG, Picornell Y, Haritunians T, Aldave AJ, Szczotka-Flynn L, Iyengar SK, Rotter JI, Taylor KD, Rabinowitz YS. An association between the calpastatin (CAST) gene and keratoconus. Cornea. 2013 May; 32(5):696-701. PMID: 23449483; PMCID: PMC3653445.
    63. Li X, Bykhovskaya Y, Canedo AL, Haritunians T, Siscovick D, Aldave AJ, Szczotka-Flynn L, Iyengar SK, Rotter JI, Taylor KD, Rabinowitz YS. Genetic association of COL5A1 variants in keratoconus patients suggests a complex connection between corneal thinning and keratoconus. Invest Ophthalmol Vis Sci. 2013 Apr 12; 54(4):2696-704. PMID: 23513063; PMCID: PMC3630822.
    64. Bakhtiari P, Frausto RF, Roldan AN, Wang C, Yu F, Aldave AJ. Exclusion of pathogenic promoter region variants and identification of novel nonsense mutations in the zinc finger E-box binding homeobox 1 gene in posterior polymorphous corneal dystrophy. Mol Vis. 2013; 19:575-80. PMID: 23559851; PMCID: PMC3611940.
    65. Goldman DR, Hubschman JP, Aldave AJ, Chiang A, Huang JS, Bourges JL, Schwartz SD. Postoperative posterior segment complications in eyes treated with the Boston type I keratoprosthesis. Retina. 2013 Mar; 33(3):532-41. PMID: 23073339.
      View in: PubMed
    66. Aldave AJ, DeMatteo J, Glasser DB, Tu EY, Iliakis B, Nordlund ML, Misko J, Verdier DD, Yu F. Report of the Eye Bank Association of America medical advisory board subcommittee on fungal infection after corneal transplantation. Cornea. 2013 Feb; 32(2):149-54. PMID: 23051906.
      View in: PubMed
    67. Kim MJ, Bakhtiari P, Aldave AJ. The international use of the Boston type I keratoprosthesis. Int Ophthalmol Clin. 2013; 53(2):79-89. PMID: 23470591.
      View in: PubMed
    68. Igo RP, Kopplin LJ, Joseph P, Truitt B, Fondran J, Bardenstein D, Aldave AJ, Croasdale CR, Price MO, Rosenwasser M, Lass JH, Iyengar SK. Differing roles for TCF4 and COL8A2 in central corneal thickness and fuchs endothelial corneal dystrophy. PLoS One. 2012; 7(10):e46742. PMID: 23110055; PMCID: PMC3479099.
    69. Stone EM, Aldave AJ, Drack AV, Maccumber MW, Sheffield VC, Traboulsi E, Weleber RG. Recommendations for genetic testing of inherited eye diseases: report of the American Academy of Ophthalmology task force on genetic testing. Ophthalmology. 2012 Nov; 119(11):2408-10. PMID: 22944025.
      View in: PubMed
    70. Bykhovskaya Y, Li X, Epifantseva I, Haritunians T, Siscovick D, Aldave A, Szczotka-Flynn L, Iyengar SK, Taylor KD, Rotter JI, Rabinowitz YS. Variation in the lysyl oxidase (LOX) gene is associated with keratoconus in family-based and case-control studies. Invest Ophthalmol Vis Sci. 2012 Jun 28; 53(7):4152-7. PMID: 22661479; PMCID: PMC3760233.
    71. Akpek EK, Aldave AJ, Aquavella JV. The use of precut, ?-irradiated corneal lenticules in Boston type 1 keratoprosthesis implantation. Am J Ophthalmol. 2012 Sep; 154(3):495-498.e1. PMID: 22633353.
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    72. Younger JR, Johnson RD, Holland GN, Page JP, Nepomuceno RL, Glasgow BJ, Aldave AJ, Yu F, Litak J, Mondino BJ. Microbiologic and histopathologic assessment of corneal biopsies in the evaluation of microbial keratitis. Am J Ophthalmol. 2012 Sep; 154(3):512-519.e2. PMID: 22626618.
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    73. Aldave AJ, Sangwan VS, Basu S, Basak SK, Hovakimyan A, Gevorgyan O, Kharashi SA, Jindan MA, Tandon R, Mascarenhas J, Malyugin B, Padilla MD, Maskati Q, Agarwala N, Hutauruk J, Sharma M, Yu F. International results with the Boston type I keratoprosthesis. Ophthalmology. 2012 Aug; 119(8):1530-8. PMID: 22512986.
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    74. Kurbanyan K, Sejpal KD, Aldave AJ, Deng SX. In vivo confocal microscopic findings in Lisch corneal dystrophy. Cornea. 2012 Apr; 31(4):437-41. PMID: 22222997.
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    75. Yellore VS, Rayner SA, Nguyen CK, Gangalum RK, Jing Z, Bhat SP, Aldave AJ. Analysis of the role of ZEB1 in the pathogenesis of posterior polymorphous corneal dystrophy. Invest Ophthalmol Vis Sci. 2012 Jan 25; 53(1):273-8. PMID: 22199242; PMCID: PMC3292363.
    76. Louttit MD, Kopplin LJ, Igo RP, Fondran JR, Tagliaferri A, Bardenstein D, Aldave AJ, Croasdale CR, Price MO, Rosenwasser GO, Lass JH, Iyengar SK. A multicenter study to map genes for Fuchs endothelial corneal dystrophy: baseline characteristics and heritability. Cornea. 2012 Jan; 31(1):26-35. PMID: 22045388; PMCID: PMC3719980.
    77. Deng SX, Sejpal KD, Tang Q, Aldave AJ, Lee OL, Yu F. Characterization of limbal stem cell deficiency by in vivo laser scanning confocal microscopy: a microstructural approach. Arch Ophthalmol. 2012 Apr; 130(4):440-5. PMID: 22159172; PMCID: PMC3928362.
    78. Wiaux C, Baghdasaryan E, Lee OL, Bourges JL, Deng SX, Yu F, Aldave AJ. Outcomes after Descemet stripping endothelial keratoplasty in glaucoma patients with previous trabeculectomy and tube shunt implantation. Cornea. 2011 Dec; 30(12):1304-11. PMID: 21963858.
      View in: PubMed
    79. Sejpal K, Yu F, Aldave AJ. The Boston keratoprosthesis in the management of corneal limbal stem cell deficiency. Cornea. 2011 Nov; 30(11):1187-94. PMID: 21885964.
      View in: PubMed
    80. Burdon KP, Macgregor S, Bykhovskaya Y, Javadiyan S, Li X, Laurie KJ, Muszynska D, Lindsay R, Lechner J, Haritunians T, Henders AK, Dash D, Siscovick D, Anand S, Aldave A, Coster DJ, Szczotka-Flynn L, Mills RA, Iyengar SK, Taylor KD, Phillips T, Montgomery GW, Rotter JI, Hewitt AW, Sharma S, Rabinowitz YS, Willoughby C, Craig JE. Association of polymorphisms in the hepatocyte growth factor gene promoter with keratoconus. Invest Ophthalmol Vis Sci. 2011 Oct 31; 52(11):8514-9. PMID: 22003120; PMCID: PMC3208191.
    81. Li X, Bykhovskaya Y, Haritunians T, Siscovick D, Aldave A, Szczotka-Flynn L, Iyengar SK, Rotter JI, Taylor KD, Rabinowitz YS. A genome-wide association study identifies a potential novel gene locus for keratoconus, one of the commonest causes for corneal transplantation in developed countries. Hum Mol Genet. 2012 Jan 15; 21(2):421-9. PMID: 21979947; PMCID: PMC3276283.
    82. Aldave AJ. The genetics of the corneal dystrophies. Dev Ophthalmol. 2011; 48:51-66. PMID: 21540631.
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    83. Aldave AJ, Baghdasaryan E, Miller KM. Descemet stripping endothelial keratoplasty after Ophtec 311 iris reconstruction lens implantation. Cornea. 2011 Apr; 30(4):405-8. PMID: 21045643.
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    84. Yellore VS, Rayner SA, Aldave AJ. TGFB1-induced extracellular expression of TGFBIp and inhibition of TGFBIp expression by RNA interference in a human corneal epithelial cell line. Invest Ophthalmol Vis Sci. 2011 Feb; 52(2):757-63. PMID: 20881301; PMCID: PMC3053104.
    85. Lai IN, Yellore VS, Rayner SA, D'Silva NC, Nguyen CK, Aldave AJ. The utility of next-generation sequencing in the evaluation of the posterior polymorphous corneal dystrophy 1 locus. Mol Vis. 2010 Dec 18; 16:2829-38. PMID: 21203404; PMCID: PMC3012649.
    86. Pineles SL, Ela-Dalman N, Rosenbaum AL, Aldave AJ, Velez FG. Binocular visual function in patients with Boston type I keratoprostheses. Cornea. 2010 Dec; 29(12):1397-400. PMID: 20847681.
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    87. Hollander DA, Giaconi JA, Holland GN, Yu F, Caprioli J, Aldave AJ, Coleman AL, Casey R, Law SK, Mondino BJ. Graft failure after penetrating keratoplasty in eyes with Ahmed valves. Am J Ophthalmol. 2010 Aug; 150(2):169-78. PMID: 20537311.
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    88. Weiss JS, Wiaux C, Yellore V, Raber I, Eagle R, Mequio M, Aldave A. Newly reported p.Asp240Asn mutation in UBIAD1 suggests central discoid corneal dystrophy is a variant of Schnyder corneal dystrophy. Cornea. 2010 Jul; 29(7):777-80. PMID: 20489584.
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    89. Ament JD, Todani A, Pineda R, Shen TT, Aldave AJ, Dohlman CH, Chodosh J. Global corneal blindness and the Boston keratoprosthesis type I. Am J Ophthalmol. 2010 Apr; 149(4):537-9. PMID: 20346774.
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    90. Aldave AJ, Rosenwasser GO, Yellore VS, Papp JC, Sobel EM, Pham MN, Chen MC, Dandekar S, Sripracha R, Rayner SA, Sassani JW, Gorin MB. Linkage of posterior amorphous corneal dystrophy to chromosome 12q21.33 and exclusion of coding region mutations in KERA, LUM, DCN, and EPYC. Invest Ophthalmol Vis Sci. 2010 Aug; 51(8):4006-12. PMID: 20357198; PMCID: PMC2910638.
    91. Aldave AJ, Kamal KM, Vo RC, Yu F. Epithelial debridement and Bowman's layer polishing for visually significant epithelial irregularity and recurrent corneal erosions. Cornea. 2009 Dec; 28(10):1085-90. PMID: 19730089.
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    92. Aldave AJ, Yellore VS, Vo RC, Kamal KM, Rayner SA, Plaisier CL, Chen MC, Damani MR, Pham MN, Gorin MB, Sobel E, Papp J. Exclusion of positional candidate gene coding region mutations in the common posterior polymorphous corneal dystrophy 1 candidate gene interval. Cornea. 2009 Aug; 28(7):801-7. PMID: 19574904; PMCID: PMC2714875.
    93. Yu L, Aldave AJ, Glasgow BJ. Epstein-Barr virus-associated smooth muscle tumor of the iris in a patient with transplant: a case report and review of the literature. Arch Pathol Lab Med. 2009 Aug; 133(8):1238-41. PMID: 19653717.
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    94. Tai TY, Damani MR, Vo R, Rayner SA, Glasgow BJ, Hofbauer JD, Casey R, Aldave AJ. Keratoconus associated with corneal stromal amyloid deposition containing TGFBIp. Cornea. 2009 Jun; 28(5):589-93. PMID: 19421032; PMCID: PMC2720051.
    95. Aldave AJ, Kamal KM, Vo RC, Yu F. The Boston type I keratoprosthesis: improving outcomes and expanding indications. Ophthalmology. 2009 Apr; 116(4):640-51. PMID: 19243830.
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    96. Kamal KM, Rayner SA, Chen MC, Aldave AJ. Classic lattice corneal dystrophy associated with monoclonal gammopathy after exclusion of a TGFBI mutation. Cornea. 2009 Jan; 28(1):97-8. PMID: 19092416; PMCID: PMC2784604.
    97. Weiss JS, Møller HU, Lisch W, Kinoshita S, Aldave AJ, Belin MW, Kivelä T, Busin M, Munier FL, Seitz B, Sutphin J, Bredrup C, Mannis MJ, Rapuano CJ, Van Rij G, Kim EK, Klintworth GK. The IC3D classification of the corneal dystrophies. Cornea. 2008 Dec; 27 Suppl 2:S1-83. PMID: 19337156; PMCID: PMC2866169.
    98. Aldave AJ. Classification of the corneal dystrophies. Arch Ophthalmol. 2008 May; 126(5):747. PMID: 18474809.
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    99. Aldave AJ, Yellore VS, Sonmez B, Bourla N, Salem AK, Khan MA, Rayner SA, Glasgow BJ. A novel variant of combined granular-lattice corneal dystrophy associated with the Met619Lys mutation in the TGFBI gene. Arch Ophthalmol. 2008 Mar; 126(3):371-7. PMID: 18332318; PMCID: PMC2860538.
    100. Aldave AJ, Yellore VS, Yu F, Bourla N, Sonmez B, Salem AK, Rayner SA, Sampat KM, Krafchak CM, Richards JE. Posterior polymorphous corneal dystrophy is associated with TCF8 gene mutations and abdominal hernia. Am J Med Genet A. 2007 Nov 01; 143A(21):2549-56. PMID: 17935237.
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    101. Yellore VS, Khan MA, Bourla N, Rayner SA, Chen MC, Sonmez B, Momi RS, Sampat KM, Gorin MB, Aldave AJ. Identification of mutations in UBIAD1 following exclusion of coding mutations in the chromosome 1p36 locus for Schnyder crystalline corneal dystrophy. Mol Vis. 2007 Sep 24; 13:1777-82. PMID: 17960116.
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    102. Aldave AJ, Bourla N, Yellore VS, Rayner SA, Khan MA, Salem AK, Sonmez B. Keratoconus is not associated with mutations in COL8A1 and COL8A2. Cornea. 2007 Sep; 26(8):963-5. PMID: 17721297.
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    103. Yellore VS, Sonmez B, Chen MC, Rayner SA, Thonar EJ, Aldave AJ. An unusual presentation of macular corneal dystrophy associated with uniparental isodisomy and a novel Leu173Pro mutation. Ophthalmic Genet. 2007 Sep; 28(3):169-74. PMID: 17896316.
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    104. Aldave AJ, Nguyen A. Ocular surface toxicity associated with topical interferon alpha-2b. Br J Ophthalmol. 2007 Aug; 91(8):1087-8. PMID: 17638822; PMCID: PMC1954794.
    105. Aldave AJ, Yellore VS, Bourla N, Momi RS, Khan MA, Salem AK, Rayner SA, Glasgow BJ, Kurtz I. Autosomal recessive CHED associated with novel compound heterozygous mutations in SLC4A11. Cornea. 2007 Aug; 26(7):896-900. PMID: 17667634.
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    106. Aldave AJ, Sonmez B, Bourla N, Schultz G, Papp JC, Salem AK, Rayner SA, Yellore VS. Autosomal dominant cornea plana is not associated with pathogenic mutations in DCN, DSPG3, FOXC1, KERA, LUM, or PITX2. Ophthalmic Genet. 2007 Jun; 28(2):57-67. PMID: 17558846.
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    107. Yellore VS, Papp JC, Sobel E, Khan MA, Rayner SA, Farber DB, Aldave AJ. Replication and refinement of linkage of posterior polymorphous corneal dystrophy to the posterior polymorphous corneal dystrophy 1 locus on chromosome 20. Genet Med. 2007 Apr; 9(4):228-34. PMID: 17438387.
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    108. Aldave AJ, Sonmez B. Elucidating the molecular genetic basis of the corneal dystrophies: are we there yet? Arch Ophthalmol. 2007 Feb; 125(2):177-86. PMID: 17296893.
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    109. Sonmez B, Kim BT, Aldave AJ. Amniotic membrane transplantation with anterior stromal micropuncture for treatment of painful bullous keratopathy in eyes with poor visual potential. Cornea. 2007 Feb; 26(2):227-9. PMID: 17251820.
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    110. Aldave AJ, Sonmez B, Forstot SL, Rayner SA, Yellore VS, Glasgow BJ. A clinical and histopathologic examination of accelerated TGFBIp deposition after LASIK in combined granular-lattice corneal dystrophy. Am J Ophthalmol. 2007 Mar; 143(3):416-9. PMID: 17317389.
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    111. Aldave AJ, Rayner SA, Salem AK, Yoo GL, Kim BT, Saeedian M, Sonmez B, Yellore VS. No pathogenic mutations identified in the COL8A1 and COL8A2 genes in familial Fuchs corneal dystrophy. Invest Ophthalmol Vis Sci. 2006 Sep; 47(9):3787-90. PMID: 16936088.
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    112. Aldave AJ, Yellore VS, Salem AK, Yoo GL, Rayner SA, Yang H, Tang GY, Piconell Y, Rabinowitz YS. No VSX1 gene mutations associated with keratoconus. Invest Ophthalmol Vis Sci. 2006 Jul; 47(7):2820-2. PMID: 16799019.
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    113. Aldave AJ, King JA, Kim BT, Hopp L. Corneal copper deposition associated with chronic lymphocytic leukemia. Am J Ophthalmol. 2006 Jul; 142(1):174-6. PMID: 16815276.
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    114. Aldave AJ, Rayner SA, King JA, Salem AK, Prechanond A, Hashida S, Affeldt JC, Meallet MA, Glasgow BJ, Small KW, Yellore VS. No pathogenic mutations identified in the TGFBI gene in polymorphic corneal amyloid deposition. Cornea. 2006 May; 25(4):413-5. PMID: 16670477.
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    115. Aldave AJ, Rayner SA, Kim BT, Prechanond A, Yellore VS. Unilateral lattice corneal dystrophy associated with the novel His572del mutation in the TGFBI gene. Mol Vis. 2006 Feb 27; 12:142-6. PMID: 16541014.
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    116. Aldave AJ, Rayner SA, Principe AH, Affeldt JA, Katsev D, Yellore VS. Analysis of fifteen positional candidate genes for Schnyder crystalline corneal dystrophy. Mol Vis. 2005 Sep 02; 11:713-6. PMID: 16163269.
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    117. Aldave AJ, Hollander DA, Glasgow BJ. Late calcific deposition on the hydrophilic acrylic MemoryLens. J Cataract Refract Surg. 2005 Sep; 31(9):1681. PMID: 16246746.
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    118. Aldave AJ, Rayner SA, King JA, Affeldt JA, Yellore VS. A unique corneal dystrophy of Bowman's layer and stroma associated with the Gly623Asp mutation in the transforming growth factor beta-induced (TGFBI) gene. Ophthalmology. 2005 Jun; 112(6):1017-22. PMID: 15885785.
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    119. Aldave AJ, Hollander DA, Branco B, Crawford B, Abbott RL. Primary graft failure associated with epithelial downgrowth: a case report. BMC Ophthalmol. 2005 May 25; 5:11. PMID: 15916712; PMCID: PMC1156905.
    120. Yellore VS, Rayner SA, Emmert-Buck L, Tabin GC, Raber I, Hannush SB, Stulting RD, Sampat K, Momi R, Principe AH, Aldave AJ. No pathogenic mutations identified in the COL8A2 gene or four positional candidate genes in patients with posterior polymorphous corneal dystrophy. Invest Ophthalmol Vis Sci. 2005 May; 46(5):1599-603. PMID: 15851557.
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    121. Aldave AJ, Yellore VS, Principe AH, Abedi G, Merrill K, Chalukya M, Small KW, Udar N. Candidate gene screening for posterior polymorphous dystrophy. Cornea. 2005 Mar; 24(2):151-5. PMID: 15725882.
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    122. Strauss EC, Aldave AJ, Spencer WH, Branco BC, Barsness DA, Calman AF, Margolis TP. Management of prominent iris vascular tufts causing recurrent spontaneous hyphema. Cornea. 2005 Mar; 24(2):224-6. PMID: 15725893.
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    123. Aldave AJ. VSX1 mutation and corneal dystrophies. Ophthalmology. 2005 Jan; 112(1):170-1; author reply 171-2. PMID: 15629844.
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    124. Aldave AJ, Principe AH, Lin DY, Yellore VS, Small KW. Lattice dystrophy-like localized amyloidosis of the cornea secondary to trichiasis. Cornea. 2005 Jan; 24(1):112-5. PMID: 15604878.
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    125. Giaconi JA, Coleman AL, Aldave AJ. Epithelial downgrowth following surgery for congenital glaucoma. Am J Ophthalmol. 2004 Dec; 138(6):1075-7. PMID: 15629317.
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    126. Hollander DA, Aldave AJ. Drug-induced corneal complications. Curr Opin Ophthalmol. 2004 Dec; 15(6):541-8. PMID: 15523201.
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    127. Aldave AJ, Gutmark JG, Yellore VS, Affeldt JA, Meallet MA, Udar N, Rao NA, Small KW, Klintworth GK. Lattice corneal dystrophy associated with the Ala546Asp and Pro551Gln missense changes in the TGFBI gene. Am J Ophthalmol. 2004 Nov; 138(5):772-81. PMID: 15531312.
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    128. Principe AH, Lin DY, Small KW, Aldave AJ. Macular hemorrhage after laser in situ keratomileusis (LASIK) with femtosecond laser flap creation. Am J Ophthalmol. 2004 Oct; 138(4):657-9. PMID: 15488801.
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    129. Aldave AJ, Yellore VS, Self CA, Holsclaw D, Small K. The usefulness of buccal swabs for mutation screening in patients with suspected corneal dystrophies. Ophthalmology. 2004 Jul; 111(7):1407-9. PMID: 15234146.
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    130. Aldave AJ, Lin DY, Principe AH, Yellore VS, Weissman BA. Anterior basement membrane corneal dystrophy and pseudo-unilateral lattice corneal dystrophy in a patient with recurrent corneal erosions. Am J Ophthalmol. 2004 Jun; 137(6):1124-7. PMID: 15183802.
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    131. Aldave AJ, Yellore VS, Thonar EJ, Udar N, Warren JF, Yoon MK, Cohen EJ, Rapuano CJ, Laibson PR, Margolis TP, Small K. Novel mutations in the carbohydrate sulfotransferase gene (CHST6) in American patients with macular corneal dystrophy. Am J Ophthalmol. 2004 Mar; 137(3):465-73. PMID: 15013869.
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    132. Warren JF, Aldave AJ, Srinivasan M, Thonar EJ, Kumar AB, Cevallos V, Whitcher JP, Margolis TP. Novel mutations in the CHST6 gene associated with macular corneal dystrophy in southern India. Arch Ophthalmol. 2003 Nov; 121(11):1608-12. PMID: 14609920.
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    133. Aldave AJ, Yellore VS, Hwang DG. Atypical vortex pattern of corneal deposits in granular corneal dystrophy. Cornea. 2003 Nov; 22(8):754-9. PMID: 14576527.
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    134. Jeng BH, Aldave AJ, McLeod SD. Spontaneous corneal hydrops and perforation in both eyes of a patient with pellucid marginal degeneration. Cornea. 2003 Oct; 22(7):705-6. PMID: 14508268.
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    135. Crawford JB, Aldave AJ, McLeod S, Howes E, Schwartz D. Histopathological analysis of the cornea after laser in situ keratomileusis. Arch Ophthalmol. 2003 Jun; 121(6):896-8. PMID: 12796266.
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    136. Aldave AJ, Shih JL, Jovkar S, McLeod SD. Peripheral keratitis associated with erythema elevatum diutinum. Am J Ophthalmol. 2003 Mar; 135(3):389-90. PMID: 12614763.
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    137. Aldave AJ, Mabon M, Hollander DA, McLeod SD, Spencer WH, Abbott RL. Spontaneous corneal hydrops and perforation in keratoconus and pellucid marginal degeneration. Cornea. 2003 Mar; 22(2):169-74. PMID: 12605056.
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    138. Aldave AJ, Wong IG. A novel technique for harvesting keratolimbal allografts from corneoscleral buttons. Am J Ophthalmol. 2002 Dec; 134(6):929-31. PMID: 12470775.
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    139. Aldave AJ, Edward DP, Park AJ, Raber IM, Eagle RC. Central discoid corneal dystrophy. Cornea. 2002 Nov; 21(8):739-44. PMID: 12410027.
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    140. Aldave AJ. Examination of affected relatives and molecular genetic analysis are best means to differentiate between early granular and combined granular-lattice corneal dystrophies. Cornea. 2002 Oct; 21(7):735-6. PMID: 12352101.
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    141. Aldave AJ, Hollander DA, Abbott RL. Late-onset traumatic flap dislocation and diffuse lamellar inflammation after laser in situ keratomileusis. Cornea. 2002 Aug; 21(6):604-7. PMID: 12131040.
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    142. Hollander DA, Aldave AJ. Ocular bungee cord injuries. Curr Opin Ophthalmol. 2002 Jun; 13(3):167-70. PMID: 12011685.
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