Novitch Bennett

Title(s)Member, CTSI
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    Other Positions
    Title(s)Professor, Neurobiology

    Title(s)Member, Brain Research Institute

    Title(s)Member, Cell & Developmental Biology GPB Home Area

    Title(s)Member, Eli & Edythe Broad Center of Regenerative Medicine & Stem Cell Research

    Title(s)Member, Gene Regulation GPB Home Area

    Title(s)Member, JCCC Cancer and Stem Cell Biology Program Area

    Title(s)Member, Neuroscience GPB Home Area

    Collapse Research 
    Collapse Research Activities and Funding
    Regulation of neural progenitor functions underlying cortical growth & complexity
    NIH/NINDS R01NS089817Sep 15, 2015 - May 31, 2020
    Role: Principal Investigator
    Molecular Pathways Controlling Respiratory Motor Neuron Formation and Function
    NIH/NINDS R01NS085227May 15, 2015 - Apr 30, 2020
    Role: Principal Investigator
    Transcriptional regulation of neuronal differentiation
    NIH/NINDS R01NS072804Sep 1, 2010 - Aug 31, 2015
    Role: Principal Investigator
    Function of Olig2-Regulated Genes in Spinal Motor Neuron Development
    NIH/NINDS R01NS053976Jan 15, 2006 - Dec 31, 2011
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Andrews MG, Kong J, Novitch BG, Butler SJ. New perspectives on the mechanisms establishing the dorsal-ventral axis of the spinal cord. Curr Top Dev Biol. 2019; 132:417-450. PMID: 30797516.
      View in: PubMed
    2. Sagner A, Gaber ZB, Delile J, Kong JH, Rousso DL, Pearson CA, Weicksel SE, Melchionda M, Mousavy Gharavy SN, Briscoe J, Novitch BG. Olig2 and Hes regulatory dynamics during motor neuron differentiation revealed by single cell transcriptomics. PLoS Biol. 2018 02; 16(2):e2003127. PMID: 29389974.
      View in: PubMed
    3. Han AY, Gupta S, Novitch BG. Molecular specification of facial branchial motor neurons in vertebrates. Dev Biol. 2018 04 01; 436(1):5-13. PMID: 29391164.
      View in: PubMed
    4. Watanabe M, Buth JE, Vishlaghi N, de la Torre-Ubieta L, Taxidis J, Khakh BS, Coppola G, Pearson CA, Yamauchi K, Gong D, Dai X, Damoiseaux R, Aliyari R, Liebscher S, Schenke-Layland K, Caneda C, Huang EJ, Zhang Y, Cheng G, Geschwind DH, Golshani P, Sun R, Novitch BG. Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection. Cell Rep. 2017 Oct 10; 21(2):517-532. PMID: 29020636.
      View in: PubMed
    5. Sangwan S, Zhao A, Adams KL, Jayson CK, Sawaya MR, Guenther EL, Pan AC, Ngo J, Moore DM, Soriaga AB, Do TD, Goldschmidt L, Nelson R, Bowers MT, Koehler CM, Shaw DE, Novitch BG, Eisenberg DS. Atomic structure of a toxic, oligomeric segment of SOD1 linked to amyotrophic lateral sclerosis (ALS). Proc Natl Acad Sci U S A. 2017 08 15; 114(33):8770-8775. PMID: 28760994.
      View in: PubMed
    6. Varadarajan SG, Kong JH, Phan KD, Kao TJ, Panaitof SC, Cardin J, Eltzschig H, Kania A, Novitch BG, Butler SJ. Netrin1 Produced by Neural Progenitors, Not Floor Plate Cells, Is Required for Axon Guidance in the Spinal Cord. Neuron. 2017 May 17; 94(4):790-799.e3. PMID: 28434801.
      View in: PubMed
    7. Li C, Deng YQ, Wang S, Ma F, Aliyari R, Huang XY, Zhang NN, Watanabe M, Dong HL, Liu P, Li XF, Ye Q, Tian M, Hong S, Fan J, Zhao H, Li L, Vishlaghi N, Buth JE, Au C, Liu Y, Lu N, Du P, Qin FX, Zhang B, Gong D, Dai X, Sun R, Novitch BG, Xu Z, Qin CF, Cheng G. 25-Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model. Immunity. 2017 03 21; 46(3):446-456. PMID: 28314593.
      View in: PubMed
    8. Huang C, Su T, Xue Y, Cheng C, Lay FD, McKee RA, Li M, Vashisht A, Wohlschlegel J, Novitch BG, Plath K, Kurdistani SK, Carey M. Cbx3 maintains lineage specificity during neural differentiation. Genes Dev. 2017 02 01; 31(3):241-246. PMID: 28270516.
      View in: PubMed
    9. Linares AJ, Lin CH, Damianov A, Adams KL, Novitch BG, Black DL. The splicing regulator PTBP1 controls the activity of the transcription factor Pbx1 during neuronal differentiation. Elife. 2015 Dec 24; 4:e09268. PMID: 26705333; PMCID: PMC4755740.
    10. Kong JH, Yang L, Dessaud E, Chuang K, Moore DM, Rohatgi R, Briscoe J, Novitch BG. Notch activity modulates the responsiveness of neural progenitors to sonic hedgehog signaling. Dev Cell. 2015 May 26; 33(4):373-87. PMID: 25936505.
      View in: PubMed
    11. Adams KL, Rousso DL, Umbach JA, Novitch BG. Foxp1-mediated programming of limb-innervating motor neurons from mouse and human embryonic stem cells. Nat Commun. 2015 Apr 14; 6:6778. PMID: 25868900; PMCID: PMC4397664.
    12. Pearson CA, Butler SJ, Novitch BG. Neuronal organization: unsticking the cadherin code. Curr Biol. 2014 Dec 01; 24(23):R1127-9. PMID: 25465332.
      View in: PubMed
    13. Niewiadomski P, Kong JH, Ahrends R, Ma Y, Humke EW, Khan S, Teruel MN, Novitch BG, Rohatgi R. Gli protein activity is controlled by multisite phosphorylation in vertebrate Hedgehog signaling. Cell Rep. 2014 Jan 16; 6(1):168-181. PMID: 24373970; PMCID: PMC3915062.
    14. Xu B, Hrycaj SM, McIntyre DC, Baker NC, Takeuchi JK, Jeannotte L, Gaber ZB, Novitch BG, Wellik DM. Hox5 interacts with Plzf to restrict Shh expression in the developing forelimb. Proc Natl Acad Sci U S A. 2013 Nov 26; 110(48):19438-43. PMID: 24218595; PMCID: PMC3845161.
    15. Gaber ZB, Butler SJ, Novitch BG. PLZF regulates fibroblast growth factor responsiveness and maintenance of neural progenitors. PLoS Biol. 2013 Oct; 11(10):e1001676. PMID: 24115909; PMCID: PMC3792860.
    16. Kong JH, Butler SJ, Novitch BG. My brain told me to do it. Dev Cell. 2013 Jun 10; 25(5):436-8. PMID: 23763945.
      View in: PubMed
    17. Jacob J, Kong J, Moore S, Milton C, Sasai N, Gonzalez-Quevedo R, Terriente J, Imayoshi I, Kageyama R, Kageyama R, Wilkinson DG, Novitch BG, Briscoe J. Retinoid acid specifies neuronal identity through graded expression of Ascl1. Curr Biol. 2013 Mar 04; 23(5):412-8. PMID: 23416099; PMCID: PMC3659286.
    18. Wang Y, Kim E, Wang X, Novitch BG, Yoshikawa K, Chang LS, Zhu Y. ERK inhibition rescues defects in fate specification of Nf1-deficient neural progenitors and brain abnormalities. Cell. 2012 Aug 17; 150(4):816-30. PMID: 22901811; PMCID: PMC3427010.
    19. Roy A, Francius C, Rousso DL, Seuntjens E, Debruyn J, Luxenhofer G, Huber AB, Huylebroeck D, Novitch BG, Clotman F. Onecut transcription factors act upstream of Isl1 to regulate spinal motoneuron diversification. Development. 2012 Sep; 139(17):3109-19. PMID: 22833130; PMCID: PMC4074251.
    20. Umbach JA, Adams KL, Gundersen CB, Novitch BG. Functional neuromuscular junctions formed by embryonic stem cell-derived motor neurons. PLoS One. 2012; 7(5):e36049. PMID: 22574134; PMCID: PMC3344836.
    21. Rousso DL, Pearson CA, Gaber ZB, Miquelajauregui A, Li S, Portera-Cailliau C, Morrisey EE, Novitch BG. Foxp-mediated suppression of N-cadherin regulates neuroepithelial character and progenitor maintenance in the CNS. Neuron. 2012 Apr 26; 74(2):314-30. PMID: 22542185; PMCID: PMC3444171.
    22. Kang P, Lee HK, Glasgow SM, Finley M, Donti T, Gaber ZB, Graham BH, Foster AE, Novitch BG, Gronostajski RM, Deneen B. Sox9 and NFIA coordinate a transcriptional regulatory cascade during the initiation of gliogenesis. Neuron. 2012 Apr 12; 74(1):79-94. PMID: 22500632.
      View in: PubMed
    23. Skaggs K, Martin DM, Novitch BG. Regulation of spinal interneuron development by the Olig-related protein Bhlhb5 and Notch signaling. Development. 2011 Aug; 138(15):3199-211. PMID: 21750031; PMCID: PMC3133912.
    24. Gaber ZB, Novitch BG. All the embryo's a stage, and Olig2 in its time plays many parts. Neuron. 2011 Mar 10; 69(5):833-5. PMID: 21382543.
      View in: PubMed
    25. Huettl RE, Soellner H, Bianchi E, Novitch BG, Huber AB. Npn-1 contributes to axon-axon interactions that differentially control sensory and motor innervation of the limb. PLoS Biol. 2011 Feb; 9(2):e1001020. PMID: 21364975; PMCID: PMC3043002.
    26. Palmesino E, Rousso DL, Kao TJ, Klar A, Laufer E, Uemura O, Okamoto H, Novitch BG, Kania A. Foxp1 and lhx1 coordinate motor neuron migration with axon trajectory choice by gating Reelin signalling. PLoS Biol. 2010 Aug 10; 8(8):e1000446. PMID: 20711475; PMCID: PMC2919418.
    27. Dessaud E, Ribes V, Balaskas N, Yang LL, Pierani A, Kicheva A, Novitch BG, Briscoe J, Sasai N. Dynamic assignment and maintenance of positional identity in the ventral neural tube by the morphogen sonic hedgehog. PLoS Biol. 2010 Jun 01; 8(6):e1000382. PMID: 20532235; PMCID: PMC2879390.
    28. Ribes V, Balaskas N, Sasai N, Cruz C, Dessaud E, Cayuso J, Tozer S, Yang LL, Novitch B, Marti E, Briscoe J. Distinct Sonic Hedgehog signaling dynamics specify floor plate and ventral neuronal progenitors in the vertebrate neural tube. Genes Dev. 2010 Jun 01; 24(11):1186-200. PMID: 20516201; PMCID: PMC2878655.
    29. Novitch BG, Butler SJ. Reducing the mystery of neuronal differentiation. Cell. 2009 Sep 18; 138(6):1062-4. PMID: 19766560.
      View in: PubMed
    30. Vue TY, Bluske K, Alishahi A, Yang LL, Koyano-Nakagawa N, Novitch B, Nakagawa Y. Sonic hedgehog signaling controls thalamic progenitor identity and nuclei specification in mice. J Neurosci. 2009 Apr 08; 29(14):4484-97. PMID: 19357274; PMCID: PMC2718849.
    31. Karumbayaram S, Novitch BG, Patterson M, Umbach JA, Richter L, Lindgren A, Conway AE, Clark AT, Goldman SA, Plath K, Wiedau-Pazos M, Kornblum HI, Lowry WE. Directed differentiation of human-induced pluripotent stem cells generates active motor neurons. Stem Cells. 2009 Apr; 27(4):806-11. PMID: 19350680; PMCID: PMC2895909.
    32. Rousso DL, Gaber ZB, Wellik D, Morrisey EE, Novitch BG. Coordinated actions of the forkhead protein Foxp1 and Hox proteins in the columnar organization of spinal motor neurons. Neuron. 2008 Jul 31; 59(2):226-40. PMID: 18667151; PMCID: PMC2547125.
    33. Briscoe J, Novitch BG. Regulatory pathways linking progenitor patterning, cell fates and neurogenesis in the ventral neural tube. Philos Trans R Soc Lond B Biol Sci. 2008 Jan 12; 363(1489):57-70. PMID: 17282991; PMCID: PMC2605486.
    34. Dessaud E, Yang LL, Hill K, Cox B, Ulloa F, Ribeiro A, Mynett A, Novitch BG, Briscoe J. Interpretation of the sonic hedgehog morphogen gradient by a temporal adaptation mechanism. Nature. 2007 Nov 29; 450(7170):717-20. PMID: 18046410.
      View in: PubMed
    35. Mukouyama YS, Deneen B, Lukaszewicz A, Novitch BG, Wichterle H, Jessell TM, Anderson DJ. Olig2+ neuroepithelial motoneuron progenitors are not multipotent stem cells in vivo. Proc Natl Acad Sci U S A. 2006 Jan 31; 103(5):1551-6. PMID: 16432183; PMCID: PMC1345718.
    36. Marshall CA, Novitch BG, Goldman JE. Olig2 directs astrocyte and oligodendrocyte formation in postnatal subventricular zone cells. J Neurosci. 2005 Aug 10; 25(32):7289-98. PMID: 16093378.
      View in: PubMed
    37. Qu J, Li X, Novitch BG, Zheng Y, Kohn M, Xie JM, Kozinn S, Bronson R, Beg AA, Minden A. PAK4 kinase is essential for embryonic viability and for proper neuronal development. Mol Cell Biol. 2003 Oct; 23(20):7122-33. PMID: 14517283; PMCID: PMC230313.
    38. Bylund M, Andersson E, Novitch BG, Muhr J. Vertebrate neurogenesis is counteracted by Sox1-3 activity. Nat Neurosci. 2003 Nov; 6(11):1162-8. PMID: 14517545.
      View in: PubMed
    39. Novitch BG, Wichterle H, Jessell TM, Sockanathan S. A requirement for retinoic acid-mediated transcriptional activation in ventral neural patterning and motor neuron specification. Neuron. 2003 Sep 25; 40(1):81-95. PMID: 14527435.
      View in: PubMed