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Eisenberg David

Title(s)Distinguished Professor, Biological Chemistry
Phone(310) 206-3914
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    Other Positions
    Title(s)Professor, Biochemistry Molecular Biology

    Title(s)Professor, Chemistry and Biochemistry

    Title(s)Paul D. Boyer Professor of Molecular Biology & Biochemistry, Molecular Biology Institute

    Title(s)Investigator, Howard Hughes Medical Institute


    Collapse Research 
    Collapse Research Activities and Funding
    Identifying distinct tau polymorphs in Alzheimer?s disease and development of early diagnostics for aggregation of tau polymorphs
    NIH/NIA R56AG061847Sep 30, 2018 - Aug 31, 2019
    Role: Principal Investigator
    Structure and Inhibition of Amyloid in Alzheimer's Disease
    NIH/NIA RF1AG054022Sep 1, 2016 - Jun 30, 2021
    Role: Principal Investigator
    Development of inhibitors and diagnostics for amyloid diseases
    NIH/NIA R01AG048120Sep 1, 2014 - Mar 31, 2024
    Role: Principal Investigator
    Enhancing crystallization with binding partners, symmetry and diversity
    NIH/NIGMS P01GM098177Jun 1, 2012 - May 31, 2016
    Role: Co-Principal Investigator
    Engineering of Proteins for Crystallography
    NIH/NIGMS R01GM095847Sep 30, 2011 - Jul 31, 2015
    Role: Co-Principal Investigator
    Structural Biology of Amyloid Disease
    NIH/NIA R01AG029430Sep 1, 2007 - May 31, 2017
    Role: Principal Investigator
    A Core Database of Interacting Proteins
    NIH/NIGMS R01GM071909Jul 1, 2004 - Jun 30, 2014
    Role: Co-Principal Investigator
    SITE SPECIFIC TARGETING OF REGULATORY REGIONS OF HIV RNA
    NIH/NIGMS P01GM039558Sep 1, 1987 - Aug 31, 1997
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Warmack RA, Boyer DR, Zee CT, Richards LS, Sawaya MR, Cascio D, Gonen T, Eisenberg DS, Clarke SG. Structure of amyloid-ß (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface. Nat Commun. 2019 Jul 26; 10(1):3357. PMID: 31350392.
      View in: PubMed
    2. Cao Q, Boyer DR, Sawaya MR, Ge P, Eisenberg DS. Cryo-EM structures of four polymorphic TDP-43 amyloid cores. Nat Struct Mol Biol. 2019 Jul; 26(7):619-627. PMID: 31235914.
      View in: PubMed
    3. Lu J, Cao Q, Wang C, Zheng J, Luo F, Xie J, Li Y, Ma X, He L, Eisenberg D, Nowick J, Jiang L, Li D. Structure-Based Peptide Inhibitor Design of Amyloid-ß Aggregation. Front Mol Neurosci. 2019; 12:54. PMID: 30886570.
      View in: PubMed
    4. Saelices L, Nguyen BA, Chung K, Wang Y, Ortega A, Lee JH, Coelho T, Bijzet J, Benson MD, Eisenberg DS. A pair of peptides inhibits seeding of the hormone transporter transthyretin into amyloid fibrils. J Biol Chem. 2019 Apr 12; 294(15):6130-6141. PMID: 30733338.
      View in: PubMed
    5. Benson MD, Buxbaum JN, Eisenberg DS, Merlini G, Saraiva MJM, Sekijima Y, Sipe JD, Westermark P. Amyloid nomenclature 2018: recommendations by the International Society of Amyloidosis (ISA) nomenclature committee. Amyloid. 2018 Dec; 25(4):215-219. PMID: 30614283.
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    6. Cao Q, Shin WS, Chan H, Vuong CK, Dubois B, Li B, Murray KA, Sawaya MR, Feigon J, Black DL, Eisenberg DS, Jiang L. Author Correction: Inhibiting amyloid-ß cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design. Nat Chem. 2018 12; 10(12):1267. PMID: 30420778.
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    7. Tuukkanen AT, Freire D, Chan S, Arbing MA, Reed RW, Evans TJ, Zenkeviciute G, Kim J, Kahng S, Sawaya MR, Chaton CT, Wilmanns M, Eisenberg D, Parret AHA, Korotkov KV. Structural Variability of EspG Chaperones from Mycobacterial ESX-1, ESX-3, and ESX-5 Type VII Secretion Systems. J Mol Biol. 2019 Jan 18; 431(2):289-307. PMID: 30419243.
      View in: PubMed
    8. Vogler TO, Wheeler JR, Nguyen ED, Hughes MP, Britson KA, Lester E, Rao B, Betta ND, Whitney ON, Ewachiw TE, Gomes E, Shorter J, Lloyd TE, Eisenberg DS, Taylor JP, Johnson AM, Olwin BB, Parker R. TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle. Nature. 2018 11; 563(7732):508-513. PMID: 30464263.
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    9. Brumshtein B, Esswein SR, Sawaya MR, Rosenberg G, Ly AT, Landau M, Eisenberg DS. Identification of two principal amyloid-driving segments in variable domains of Ig light chains in systemic light-chain amyloidosis. J Biol Chem. 2018 12 21; 293(51):19659-19671. PMID: 30355736.
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    10. Cao Q, Shin WS, Chan H, Vuong CK, Dubois B, Li B, Murray KA, Sawaya MR, Feigon J, Black DL, Eisenberg DS, Jiang L. Inhibiting amyloid-ß cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design. Nat Chem. 2018 12; 10(12):1213-1221. PMID: 30297750.
      View in: PubMed
    11. Saelices L, Pokrzywa M, Pawelek K, Eisenberg DS. Assessment of the effects of transthyretin peptide inhibitors in Drosophila models of neuropathic ATTR. Neurobiol Dis. 2018 Dec; 120:118-125. PMID: 30213731.
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    12. Li B, Ge P, Murray KA, Sheth P, Zhang M, Nair G, Sawaya MR, Shin WS, Boyer DR, Ye S, Eisenberg DS, Zhou ZH, Jiang L. Cryo-EM of full-length a-synuclein reveals fibril polymorphs with a common structural kernel. Nat Commun. 2018 09 06; 9(1):3609. PMID: 30190461.
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    13. McPartland L, Heller DM, Eisenberg DS, Hochschild A, Sawaya MR. Atomic insights into the genesis of cellular filaments by globular proteins. Nat Struct Mol Biol. 2018 Aug; 25(8):705-714. PMID: 30076408.
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    14. Eisenberg DS. Paul D. Boyer (1918-2018). Science. 2018 Jul 27; 361(6400):334. PMID: 30049866.
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    15. Saelices L, Chung K, Lee JH, Cohn W, Whitelegge JP, Benson MD, Eisenberg DS. Amyloid seeding of transthyretin by ex vivo cardiac fibrils and its inhibition. Proc Natl Acad Sci U S A. 2018 07 17; 115(29):E6741-E6750. PMID: 29954863.
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    16. Eisenberg DS. How Hard It Is Seeing What Is in Front of Your Eyes. Cell. 2018 06 28; 174(1):8-11. PMID: 29958112.
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    17. Saelices L, Sievers SA, Sawaya MR, Eisenberg DS. Crystal structures of amyloidogenic segments of human transthyretin. Protein Sci. 2018 07; 27(7):1295-1303. PMID: 29626847.
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    18. Guenther EL, Cao Q, Trinh H, Lu J, Sawaya MR, Cascio D, Boyer DR, Rodriguez JA, Hughes MP, Eisenberg DS. Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation. Nat Struct Mol Biol. 2018 Jun; 25(6):463-471. PMID: 29786080.
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    19. Guenther EL, Ge P, Trinh H, Sawaya MR, Cascio D, Boyer DR, Gonen T, Zhou ZH, Eisenberg DS. Atomic-level evidence for packing and positional amyloid polymorphism by segment from TDP-43 RRM2. Nat Struct Mol Biol. 2018 Apr; 25(4):311-319. PMID: 29531287.
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    20. Sangwan S, Sawaya MR, Murray KA, Hughes MP, Eisenberg DS. Atomic structures of corkscrew-forming segments of SOD1 reveal varied oligomer conformations. Protein Sci. 2018 07; 27(7):1231-1242. PMID: 29453800.
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    21. Do TD, Sangwan S, de Almeida NEC, Ilitchev AI, Giammona M, Sawaya MR, Buratto SK, Eisenberg DS, Bowers MT. Distal amyloid ß-protein fragments template amyloid assembly. Protein Sci. 2018 07; 27(7):1181-1190. PMID: 29349888.
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    22. Hughes MP, Sawaya MR, Boyer DR, Goldschmidt L, Rodriguez JA, Cascio D, Chong L, Gonen T, Eisenberg DS. Atomic structures of low-complexity protein segments reveal kinked ß sheets that assemble networks. Science. 2018 02 09; 359(6376):698-701. PMID: 29439243.
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    23. Gallagher-Jones M, Glynn C, Boyer DR, Martynowycz MW, Hernandez E, Miao J, Zee CT, Novikova IV, Goldschmidt L, McFarlane HT, Helguera GF, Evans JE, Sawaya MR, Cascio D, Eisenberg DS, Gonen T, Rodriguez JA. Sub-ångström cryo-EM structure of a prion protofibril reveals a polar clasp. Nat Struct Mol Biol. 2018 Feb; 25(2):131-134. PMID: 29335561.
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    24. Hanczyc P, Mikhailovsky A, Boyer DR, Sawaya MR, Heeger A, Eisenberg D. Ultrafast Time-Resolved Studies on Fluorescein for Recognition Strands Architecture in Amyloid Fibrils. J Phys Chem B. 2018 01 11; 122(1):8-18. PMID: 29237120.
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    25. Krotee P, Griner SL, Sawaya MR, Cascio D, Rodriguez JA, Shi D, Philipp S, Murray K, Saelices L, Lee J, Seidler P, Glabe CG, Jiang L, Gonen T, Eisenberg DS. Common fibrillar spines of amyloid-ß and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors. J Biol Chem. 2018 02 23; 293(8):2888-2902. PMID: 29282295.
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    26. Kurt TD, Aguilar-Calvo P, Jiang L, Rodriguez JA, Alderson N, Eisenberg DS, Sigurdson CJ. Asparagine and glutamine ladders promote cross-species prion conversion. J Biol Chem. 2017 11 17; 292(46):19076-19086. PMID: 28931606.
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    27. Rodriguez JA, Jiang L, Eisenberg DS. Toward the Atomic Structure of PrPSc. Cold Spring Harb Perspect Biol. 2017 Sep 01; 9(9). PMID: 28096267.
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    28. Sangwan S, Zhao A, Adams KL, Jayson CK, Sawaya MR, Guenther EL, Pan AC, Ngo J, Moore DM, Soriaga AB, Do TD, Goldschmidt L, Nelson R, Bowers MT, Koehler CM, Shaw DE, Novitch BG, Eisenberg DS. Atomic structure of a toxic, oligomeric segment of SOD1 linked to amyotrophic lateral sclerosis (ALS). Proc Natl Acad Sci U S A. 2017 08 15; 114(33):8770-8775. PMID: 28760994.
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    29. Goedert M, Eisenberg DS, Crowther RA. Propagation of Tau Aggregates and Neurodegeneration. Annu Rev Neurosci. 2017 07 25; 40:189-210. PMID: 28772101.
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    30. Eisenberg DS, Sawaya MR. Neurodegeneration: Taming tangled tau. Nature. 2017 07 13; 547(7662):170-171. PMID: 28678777.
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    31. Rodriguez JA, Eisenberg DS, Gonen T. Taking the measure of MicroED. Curr Opin Struct Biol. 2017 10; 46:79-86. PMID: 28648726.
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    32. Popp D, Loh ND, Zorgati H, Ghoshdastider U, Liow LT, Ivanova MI, Larsson M, DePonte DP, Bean R, Beyerlein KR, Gati C, Oberthuer D, Arnlund D, Brändén G, Berntsen P, Cascio D, Chavas LMG, Chen JPJ, Ding K, Fleckenstein H, Gumprecht L, Harimoorthy R, Mossou E, Sawaya MR, Brewster AS, Hattne J, Sauter NK, Seibert M, Seuring C, Stellato F, Tilp T, Eisenberg DS, Messerschmidt M, Williams GJ, Koglin JE, Makowski L, Millane RP, Forsyth T, Boutet S, White TA, Barty A, Chapman H, Chen SL, Liang M, Neutze R, Robinson RC. Flow-aligned, single-shot fiber diffraction using a femtosecond X-ray free-electron laser. Cytoskeleton (Hoboken). 2017 Dec; 74(12):472-481. PMID: 28574190.
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    33. Buchner J, Eisenberg D, Schmid F. In memoriam-Rainer Jaenicke. Protein Sci. 2017 03; 26(3):394-395. PMID: 27977893.
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    34. de la Cruz MJ, Hattne J, Shi D, Seidler P, Rodriguez J, Reyes FE, Sawaya MR, Cascio D, Weiss SC, Kim SK, Hinck CS, Hinck AP, Calero G, Eisenberg D, Gonen T. Atomic-resolution structures from fragmented protein crystals with the cryoEM method MicroED. Nat Methods. 2017 Feb 13; 14(4):399-402. PMID: 28192420.
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    35. Krotee P, Rodriguez JA, Sawaya MR, Cascio D, Reyes FE, Shi D, Hattne J, Nannenga BL, Oskarsson ME, Philipp S, Griner S, Jiang L, Glabe CG, Westermark GT, Gonen T, Eisenberg DS. Atomic structures of fibrillar segments of hIAPP suggest tightly mated ß-sheets are important for cytotoxicity. Elife. 2017 01 03; 6. PMID: 28045370.
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    36. Eisenberg DS, Sawaya MR. Structural Studies of Amyloid Proteins at the Molecular Level. Annu Rev Biochem. 2017 06 20; 86:69-95. PMID: 28125289.
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    37. Riek R, Eisenberg DS. The activities of amyloids from a structural perspective. Nature. 2016 11 10; 539(7628):227-235. PMID: 27830791.
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    38. Colletier JP, Sawaya MR, Gingery M, Rodriguez JA, Cascio D, Brewster AS, Michels-Clark T, Hice RH, Coquelle N, Boutet S, Williams GJ, Messerschmidt M, DePonte DP, Sierra RG, Laksmono H, Koglin JE, Hunter MS, Park HW, Uervirojnangkoorn M, Bideshi DK, Brunger AT, Federici BA, Sauter NK, Eisenberg DS. De novo phasing with X-ray laser reveals mosquito larvicide BinAB structure. Nature. 2016 11 03; 539(7627):43-47. PMID: 27680699.
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    39. Sawaya MR, Rodriguez J, Cascio D, Collazo MJ, Shi D, Reyes FE, Hattne J, Gonen T, Eisenberg DS. Ab initio structure determination from prion nanocrystals at atomic resolution by MicroED. Proc Natl Acad Sci U S A. 2016 10 04; 113(40):11232-11236. PMID: 27647903.
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    40. Eisenberg DS, Sawaya MR. Implications for Alzheimer's disease of an atomic resolution structure of amyloid-ß(1-42) fibrils. Proc Natl Acad Sci U S A. 2016 08 23; 113(34):9398-400. PMID: 27506787.
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    41. Wagner JM, Chan S, Evans TJ, Kahng S, Kim J, Arbing MA, Eisenberg D, Korotkov KV. Structures of EccB1 and EccD1 from the core complex of the mycobacterial ESX-1 type VII secretion system. BMC Struct Biol. 2016 Feb 27; 16:5. PMID: 26922638.
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    42. Soriaga AB, Sangwan S, Macdonald R, Sawaya MR, Eisenberg D. Crystal Structures of IAPP Amyloidogenic Segments Reveal a Novel Packing Motif of Out-of-Register Beta Sheets. J Phys Chem B. 2016 07 07; 120(26):5810-6. PMID: 26629790.
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    43. Do TD, LaPointe NE, Nelson R, Krotee P, Hayden EY, Ulrich B, Quan S, Feinstein SC, Teplow DB, Eisenberg D, Shea JE, Bowers MT. Amyloid ß-Protein C-Terminal Fragments: Formation of Cylindrins and ß-Barrels. J Am Chem Soc. 2016 Jan 20; 138(2):549-57. PMID: 26700445; PMCID: PMC4741107 [Available on 01/20/17].
    44. Moshe A, Landau M, Eisenberg D. Preparation of Crystalline Samples of Amyloid Fibrils and Oligomers. Methods Mol Biol. 2016; 1345:201-10. PMID: 26453214.
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    45. Sangwan S, Eisenberg DS. Perspective on SOD1 mediated toxicity in Amyotrophic Lateral Sclerosis. Postepy Biochem. 2016; 62(3):362-369. PMID: 28132491.
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    46. Soragni A, Janzen DM, Johnson LM, Lindgren AG, Thai-Quynh Nguyen A, Tiourin E, Soriaga AB, Lu J, Jiang L, Faull KF, Pellegrini M, Memarzadeh S, Eisenberg DS. A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas. Cancer Cell. 2016 Jan 11; 29(1):90-103. PMID: 26748848; PMCID: PMC4733364 [Available on 01/11/17].
    47. Yin JX, Maalouf M, Han P, Zhao M, Gao M, Dharshaun T, Ryan C, Whitelegge J, Wu J, Eisenberg D, Reiman EM, Schweizer FE, Shi J. Ketones block amyloid entry and improve cognition in an Alzheimer's model. Neurobiol Aging. 2016 Mar; 39:25-37. PMID: 26923399.
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    48. Brumshtein B, Esswein SR, Salwinski L, Phillips ML, Ly AT, Cascio D, Sawaya MR, Eisenberg DS. Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain. Elife. 2015 Nov 18; 4:e10935. PMID: 26576950; PMCID: PMC4758944.
    49. Saelices L, Johnson LM, Liang WY, Sawaya MR, Cascio D, Ruchala P, Whitelegge J, Jiang L, Riek R, Eisenberg DS. Uncovering the Mechanism of Aggregation of Human Transthyretin. J Biol Chem. 2015 Nov 27; 290(48):28932-43. PMID: 26459562.
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    50. Rodriguez JA, Ivanova MI, Sawaya MR, Cascio D, Reyes FE, Shi D, Sangwan S, Guenther EL, Johnson LM, Zhang M, Jiang L, Arbing MA, Nannenga BL, Hattne J, Whitelegge J, Brewster AS, Messerschmidt M, Boutet S, Sauter NK, Gonen T, Eisenberg DS. Structure of the toxic core of a-synuclein from invisible crystals. Nature. 2015 Sep 24; 525(7570):486-90. PMID: 26352473.
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    51. Kurt TD, Jiang L, Fernández-Borges N, Bett C, Liu J, Yang T, Spraker TR, Castilla J, Eisenberg D, Kong Q, Sigurdson CJ. Human prion protein sequence elements impede cross-species chronic wasting disease transmission. J Clin Invest. 2015 Jun; 125(6):2548. PMID: 25961458; PMCID: PMC4497774.
    52. Soragni A, Yousefi S, Stoeckle C, Soriaga AB, Sawaya MR, Kozlowski E, Schmid I, Radonjic-Hoesli S, Boutet S, Williams GJ, Messerschmidt M, Seibert MM, Cascio D, Zatsepin NA, Burghammer M, Riekel C, Colletier JP, Riek R, Eisenberg DS, Simon HU. Toxicity of eosinophil MBP is repressed by intracellular crystallization and promoted by extracellular aggregation. Mol Cell. 2015 Mar 19; 57(6):1011-1021. PMID: 25728769.
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    53. Kurt TD, Jiang L, Fernández-Borges N, Bett C, Liu J, Yang T, Spraker TR, Castilla J, Eisenberg D, Kong Q, Sigurdson CJ. Human prion protein sequence elements impede cross-species chronic wasting disease transmission. J Clin Invest. 2015 Apr; 125(4):1485-96. PMID: 25705888; PMCID: PMC4396485.
    54. Brewster AS, Sawaya MR, Rodriguez J, Hattne J, Echols N, McFarlane HT, Cascio D, Adams PD, Eisenberg DS, Sauter NK. Indexing amyloid peptide diffraction from serial femtosecond crystallography: new algorithms for sparse patterns. Acta Crystallogr D Biol Crystallogr. 2015 Feb; 71(Pt 2):357-66. PMID: 25664747.
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    55. Li D, Jones EM, Sawaya MR, Furukawa H, Luo F, Ivanova M, Sievers SA, Wang W, Yaghi OM, Liu C, Eisenberg DS. Structure-based design of functional amyloid materials. J Am Chem Soc. 2014 Dec 31; 136(52):18044-51. PMID: 25474758.
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    56. Eisenberg D, Ahn HS, Bard AJ. Enhanced photoelectrochemical water oxidation on bismuth vanadate by electrodeposition of amorphous titanium dioxide. J Am Chem Soc. 2014 Oct 08; 136(40):14011-4. PMID: 25243345.
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    57. Brumshtein B, Esswein SR, Landau M, Ryan CM, Whitelegge JP, Phillips ML, Cascio D, Sawaya MR, Eisenberg DS. Formation of amyloid fibers by monomeric light chain variable domains. J Biol Chem. 2014 Oct 03; 289(40):27513-25. PMID: 25138218.
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    58. Sawaya MR, Cascio D, Gingery M, Rodriguez J, Goldschmidt L, Colletier JP, Messerschmidt MM, Boutet S, Koglin JE, Williams GJ, Brewster AS, Nass K, Hattne J, Botha S, Doak RB, Shoeman RL, DePonte DP, Park HW, Federici BA, Sauter NK, Schlichting I, Eisenberg DS. Protein crystal structure obtained at 2.9 Å resolution from injecting bacterial cells into an X-ray free-electron laser beam. Proc Natl Acad Sci U S A. 2014 Sep 02; 111(35):12769-74. PMID: 25136092; PMCID: PMC4156696.
    59. Do TD, LaPointe NE, Sangwan S, Teplow DB, Feinstein SC, Sawaya MR, Eisenberg DS, Bowers MT. Factors that drive peptide assembly from native to amyloid structures: experimental and theoretical analysis of [leu-5]-enkephalin mutants. J Phys Chem B. 2014 Jul 03; 118(26):7247-56. PMID: 24915112.
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    60. Hochberg GK, Ecroyd H, Liu C, Cox D, Cascio D, Sawaya MR, Collier MP, Stroud J, Carver JA, Baldwin AJ, Robinson CV, Eisenberg DS, Benesch JL, Laganowsky A. The structured core domain of aB-crystallin can prevent amyloid fibrillation and associated toxicity. Proc Natl Acad Sci U S A. 2014 Apr 22; 111(16):E1562-70. PMID: 24711386; PMCID: PMC4000792.
    61. Korman TP, Sahachartsiri B, Li D, Vinokur JM, Eisenberg D, Bowie JU. A synthetic biochemistry system for the in vitro production of isoprene from glycolysis intermediates. Protein Sci. 2014 May; 23(5):576-85. PMID: 24623472; PMCID: PMC4005709.
    62. Kurt TD, Jiang L, Bett C, Eisenberg D, Sigurdson CJ. A proposed mechanism for the promotion of prion conversion involving a strictly conserved tyrosine residue in the ß2-a2 loop of PrPC. J Biol Chem. 2014 Apr 11; 289(15):10660-7. PMID: 24596090; PMCID: PMC4036184.
    63. Goldschmidt L, Eisenberg D, Derewenda ZS. Salvage or recovery of failed targets by mutagenesis to reduce surface entropy. Methods Mol Biol. 2014; 1140:201-9. PMID: 24590720.
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    64. Li D, Furukawa H, Deng H, Liu C, Yaghi OM, Eisenberg DS. Designed amyloid fibers as materials for selective carbon dioxide capture. Proc Natl Acad Sci U S A. 2014 Jan 07; 111(1):191-6. PMID: 24367077; PMCID: PMC3890842.
    65. Ivanova MI, Sievers SA, Guenther EL, Johnson LM, Winkler DD, Galaleldeen A, Sawaya MR, Hart PJ, Eisenberg DS. Aggregation-triggering segments of SOD1 fibril formation support a common pathway for familial and sporadic ALS. Proc Natl Acad Sci U S A. 2014 Jan 07; 111(1):197-201. PMID: 24344300; PMCID: PMC3890817.
    66. Arbing MA, Chan S, Harris L, Kuo E, Zhou TT, Ahn CJ, Nguyen L, He Q, Lu J, Menchavez PT, Shin A, Holton T, Sawaya MR, Cascio D, Eisenberg D. Heterologous expression of mycobacterial Esx complexes in Escherichia coli for structural studies is facilitated by the use of maltose binding protein fusions. PLoS One. 2013; 8(11):e81753. PMID: 24312350.
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    67. Jiang L, Liu C, Leibly D, Landau M, Zhao M, Hughes MP, Eisenberg DS. Structure-based discovery of fiber-binding compounds that reduce the cytotoxicity of amyloid beta. Elife. 2013 Jul 16; 2:e00857. PMID: 23878726.
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    68. Miallau L, Jain P, Arbing MA, Cascio D, Phan T, Ahn CJ, Chan S, Chernishof I, Maxson M, Chiang J, Jacobs WR, Eisenberg DS. Comparative proteomics identifies the cell-associated lethality of M. tuberculosis RelBE-like toxin-antitoxin complexes. Structure. 2013 Apr 02; 21(4):627-37. PMID: 23523424.
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    69. Liu C, Zhao M, Jiang L, Cheng PN, Park J, Sawaya MR, Pensalfini A, Gou D, Berk AJ, Glabe CG, Nowick J, Eisenberg D. Out-of-register ß-sheets suggest a pathway to toxic amyloid aggregates. Proc Natl Acad Sci U S A. 2012 Dec 18; 109(51):20913-8. PMID: 23213214; PMCID: PMC3529048.
    70. Min AB, Miallau L, Sawaya MR, Habel J, Cascio D, Eisenberg D. The crystal structure of the Rv0301-Rv0300 VapBC-3 toxin-antitoxin complex from M. tuberculosis reveals a Mg²? ion in the active site and a putative RNA-binding site. Protein Sci. 2012 Nov; 21(11):1754-67. PMID: 23011806.
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    71. Cheng PN, Liu C, Zhao M, Eisenberg D, Nowick JS. Amyloid ß-sheet mimics that antagonize protein aggregation and reduce amyloid toxicity. Nat Chem. 2012 Nov; 4(11):927-33. PMID: 23089868; PMCID: PMC3481199.
    72. Kato M, Han TW, Xie S, Shi K, Du X, Wu LC, Mirzaei H, Goldsmith EJ, Longgood J, Pei J, Grishin NV, Frantz DE, Schneider JW, Chen S, Li L, Sawaya MR, Eisenberg D, Tycko R, McKnight SL. Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels. Cell. 2012 May 11; 149(4):753-67. PMID: 22579281.
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    73. Stroud JC, Liu C, Teng PK, Eisenberg D. Toxic fibrillar oligomers of amyloid-ß have cross-ß structure. Proc Natl Acad Sci U S A. 2012 May 15; 109(20):7717-22. PMID: 22547798; PMCID: PMC3356606.
    74. Eisenberg D, Jucker M. The amyloid state of proteins in human diseases. Cell. 2012 Mar 16; 148(6):1188-203. PMID: 22424229; PMCID: PMC3353745.
    75. Laganowsky A, Liu C, Sawaya MR, Whitelegge JP, Park J, Zhao M, Pensalfini A, Soriaga AB, Landau M, Teng PK, Cascio D, Glabe C, Eisenberg D. Atomic view of a toxic amyloid small oligomer. Science. 2012 Mar 09; 335(6073):1228-31. PMID: 22403391; PMCID: PMC3959867.
    76. Teng PK, Anderson NJ, Goldschmidt L, Sawaya MR, Sambashivan S, Eisenberg D. Ribonuclease A suggests how proteins self-chaperone against amyloid fiber formation. Protein Sci. 2012 Jan; 21(1):26-37. PMID: 22095666; PMCID: PMC3323778.
    77. Colletier JP, Laganowsky A, Landau M, Zhao M, Soriaga AB, Goldschmidt L, Flot D, Cascio D, Sawaya MR, Eisenberg D. Molecular basis for amyloid-beta polymorphism. Proc Natl Acad Sci U S A. 2011 Oct 11; 108(41):16938-43. PMID: 21949245.
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    170. Diaz-Avalos R, Long C, Fontano E, Balbirnie M, Grothe R, Eisenberg D, Caspar DL. Cross-beta order and diversity in nanocrystals of an amyloid-forming peptide. J Mol Biol. 2003 Jul 25; 330(5):1165-75. PMID: 12860136.
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    171. Salwinski L, Eisenberg D. Computational methods of analysis of protein-protein interactions. Curr Opin Struct Biol. 2003 Jun; 13(3):377-82. PMID: 12831890.
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    172. Freedland SJ, Pantuck AJ, Paik SH, Zisman A, Graeber TG, Eisenberg D, McBride WH, Nguyen D, Tso CL, Belldegrun AS. Heterogeneity of molecular targets on clonal cancer lines derived from a novel hormone-refractory prostate cancer tumor system. Prostate. 2003 Jun 01; 55(4):299-307. PMID: 12712409.
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    173. Wang S, Eisenberg D. Crystal structures of a pantothenate synthetase from M. tuberculosis and its complexes with substrates and a reaction intermediate. Protein Sci. 2003 May; 12(5):1097-108. PMID: 12717031.
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    174. Mura C, Kozhukhovsky A, Gingery M, Phillips M, Eisenberg D. The oligomerization and ligand-binding properties of Sm-like archaeal proteins (SmAPs). Protein Sci. 2003 Apr; 12(4):832-47. PMID: 12649441.
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    175. Mura C, Phillips M, Kozhukhovsky A, Eisenberg D. Structure and assembly of an augmented Sm-like archaeal protein 14-mer. Proc Natl Acad Sci U S A. 2003 Apr 15; 100(8):4539-44. PMID: 12668760; PMCID: PMC404694.
    176. Mura C, Katz JE, Clarke SG, Eisenberg D. Structure and function of an archaeal homolog of survival protein E (SurEalpha): an acid phosphatase with purine nucleotide specificity. J Mol Biol. 2003 Mar 07; 326(5):1559-75. PMID: 12595266.
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    177. McCarty AS, Kleiger G, Eisenberg D, Smale ST. Selective dimerization of a C2H2 zinc finger subfamily. Mol Cell. 2003 Feb; 11(2):459-70. PMID: 12620233.
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    178. Anderson DH, Sawaya MR, Cascio D, Ernst W, Modlin R, Krensky A, Eisenberg D. Granulysin crystal structure and a structure-derived lytic mechanism. J Mol Biol. 2003 Jan 10; 325(2):355-65. PMID: 12488100.
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    179. Eisenberg D. John T. Edsall as tutor and teacher. Biophys Chem. 2003; 100(1-3):91-3. PMID: 12646352.
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    180. Mallick P, Weiss R, Eisenberg D. The directional atomic solvation energy: an atom-based potential for the assignment of protein sequences to known folds. Proc Natl Acad Sci U S A. 2002 Dec 10; 99(25):16041-6. PMID: 12461172; PMCID: PMC138561.
    181. Goulding CW, Parseghian A, Sawaya MR, Cascio D, Apostol MI, Gennaro ML, Eisenberg D. Crystal structure of a major secreted protein of Mycobacterium tuberculosis-MPT63 at 1.5-A resolution. Protein Sci. 2002 Dec; 11(12):2887-93. PMID: 12441386.
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    182. Kleiger G, Eisenberg D. GXXXG and GXXXA motifs stabilize FAD and NAD(P)-binding Rossmann folds through C(alpha)-H... O hydrogen bonds and van der waals interactions. J Mol Biol. 2002 Oct 11; 323(1):69-76. PMID: 12368099.
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    183. Gill HS, Pfluegl GM, Eisenberg D. Multicopy crystallographic refinement of a relaxed glutamine synthetase from Mycobacterium tuberculosis highlights flexible loops in the enzymatic mechanism and its regulation. Biochemistry. 2002 Aug 06; 41(31):9863-72. PMID: 12146952.
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    184. Mallick P, Boutz DR, Eisenberg D, Yeates TO. Genomic evidence that the intracellular proteins of archaeal microbes contain disulfide bonds. Proc Natl Acad Sci U S A. 2002 Jul 23; 99(15):9679-84. PMID: 12107280; PMCID: PMC124975.
    185. Goulding CW, Sawaya MR, Parseghian A, Lim V, Eisenberg D, Missiakas D. Thiol-disulfide exchange in an immunoglobulin-like fold: structure of the N-terminal domain of DsbD. Biochemistry. 2002 Jun 04; 41(22):6920-7. PMID: 12033924.
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    186. Goulding CW, Apostol M, Anderson DH, Gill HS, Smith CV, Kuo MR, Yang JK, Waldo GS, Suh SW, Chauhan R, Kale A, Bachhawat N, Mande SC, Johnston JM, Lott JS, Baker EN, Arcus VL, Leys D, McLean KJ, Munro AW, Berendzen J, Sharma V, Park MS, Eisenberg D, Sacchettini J, Alber T, Rupp B, Jacobs W, Terwilliger TC. The TB structural genomics consortium: providing a structural foundation for drug discovery. Curr Drug Targets Infect Disord. 2002 Jun; 2(2):121-41. PMID: 12462144.
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    187. Liu Y, Eisenberg D. 3D domain swapping: as domains continue to swap. Protein Sci. 2002 Jun; 11(6):1285-99. PMID: 12021428; PMCID: PMC2373619.
    188. Ghirlanda G, Lear JD, Ogihara NL, Eisenberg D, DeGrado WF. A hierarchic approach to the design of hexameric helical barrels. J Mol Biol. 2002 May 24; 319(1):243-53. PMID: 12051949.
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    189. Kleiger G, Grothe R, Mallick P, Eisenberg D. GXXXG and AXXXA: common alpha-helical interaction motifs in proteins, particularly in extremophiles. Biochemistry. 2002 May 14; 41(19):5990-7. PMID: 11993993.
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    190. Deane CM, Salwinski L, Xenarios I, Eisenberg D. Protein interactions: two methods for assessment of the reliability of high throughput observations. Mol Cell Proteomics. 2002 May; 1(5):349-56. PMID: 12118076.
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    191. Wang S, Mura C, Sawaya MR, Cascio D, Eisenberg D. Structure of a Nudix protein from Pyrobaculum aerophilum reveals a dimer with two intersubunit beta-sheets. Acta Crystallogr D Biol Crystallogr. 2002 Apr; 58(Pt 4):571-8. PMID: 11914479.
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    192. Liu Y, Gotte G, Libonati M, Eisenberg D. Structures of the two 3D domain-swapped RNase A trimers. Protein Sci. 2002 Feb; 11(2):371-80. PMID: 11790847.
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    193. Duan XJ, Xenarios I, Eisenberg D. Describing biological protein interactions in terms of protein states and state transitions: the LiveDIP database. Mol Cell Proteomics. 2002 Feb; 1(2):104-16. PMID: 12096128.
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    194. Eisenberg DS, Kuriyan J, Richards FM. John T. Edsall and Advances in Protein Chemistry. Adv Protein Chem. 2002; 62:xi-xiv. PMID: 12418097.
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    195. Xenarios I, Salwínski L, Duan XJ, Higney P, Kim SM, Eisenberg D. DIP, the Database of Interacting Proteins: a research tool for studying cellular networks of protein interactions. Nucleic Acids Res. 2002 Jan 01; 30(1):303-5. PMID: 11752321; PMCID: PMC99070.
    196. Eisenberg D, Marcotte EM, Xenarios I, Yeates TO. Protein function in the post-genomic era. Nature. 2000 Jun 15; 405(6788):823-6. PMID: 10866208.
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    197. Eisenberg D, Gill HS, Pfluegl GM, Rotstein SH. Structure-function relationships of glutamine synthetases. Biochim Biophys Acta. 2000 Mar 07; 1477(1-2):122-45. PMID: 10708854.
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    198. Eisenberg D. How chaperones protect virgin proteins. Science. 1999 Aug 13; 285(5430):1021-2. PMID: 10475844.
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