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Wong David

TitleAssociate Dean for Research
InstitutionUniversity of California Los Angeles
DepartmentDentistry
Address10833 Le Conte Avenue
73-017 CHS
Los Angeles CA 90095
Phone(310) 206-3048
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    Other Positions
    TitleProfessor

    TitleDirector


    Collapse Research 
    Collapse Research Activities and Funding
    Advancing EFIRM-Liquid Biopsy (eLB) to a CLIA-Certified Laboratory Developed Test (eLB-LDT) for Detection of Actionable EGFR Mutations in NSCLC Patients
    NIH/NCI UH2CA206126Mar 6, 2017 - Feb 28, 2019
    Role: Principal Investigator
    Clinical Utility of Salivary ExRNA Biomarkers for Gastric Cancer Detection
    NIH/NCATS UH3TR000923Aug 1, 2013 - Jul 31, 2018
    Role: Principal Investigator
    Clinical Utility of Salivary ExRNA Biomarkers for Gastric Cancer Detection
    NIH/NCATS UH2TR000923Aug 1, 2013 - Jul 31, 2015
    Role: Principal Investigator
    Molecular Characterization of Parotid Gland Tumors
    NIH/NIDCR R56DE023241Sep 7, 2012 - Aug 31, 2014
    Role: Principal Investigator
    UCLA Dentist-Scientist and Oral Health-Researcher Training Program
    NIH/NIDCR T90DE022734Jul 1, 2012 - Jun 30, 2018
    Role: Principal Investigator
    UCLA Dentist-Scientist and Oral Health-Researcher Training Program
    NIH/NIDCR R90DE023057Jul 1, 2012 - Jun 30, 2017
    Role: Principal Investigator
    Systems Approach to Sjogren's Syndrome Pathogenesis (SASSP)
    NIH/NIDCR R01DE019255May 1, 2009 - Apr 30, 2012
    Role: Co-Principal Investigator
    Molecular Determinants of Oral Tongue Cancer Metastasis
    NIH/NCI R01CA139596Sep 8, 2008 - Jul 31, 2014
    Role: Principal Investigator
    Salivary Biomarkers for Early Oral Cancer Detection
    NIH/NIDCR R01DE017170Apr 1, 2008 - Mar 31, 2013
    Role: Principal Investigator
    Collection, Stabilization and Storage of Saliva Samples for Cancer Research
    NIH/NCI R21CA126733Apr 1, 2008 - Mar 31, 2011
    Role: Principal Investigator
    Oral Fluid NanoSensor Test (OFNASET)
    NIH/NIDCR U01DE017790Sep 1, 2006 - Feb 28, 2012
    Role: Principal Investigator
    Salivary Biomarkers for Sjogren's Syndrome Detection-Definitive Validation
    NIH/NIDCR U01DE017593Aug 1, 2006 - Aug 31, 2015
    Role: Principal Investigator
    Salivary Proteomic &Genomic Biomarkers for Primary Sjogren's Syndrome
    NIH/NIDCR R01DE017593Aug 1, 2006 - Sep 14, 2011
    Role: Principal Investigator
    Human Salivary Proteome
    NIH/NIDCR U01DE016275Sep 24, 2004 - May 31, 2010
    Role: Principal Investigator
    Genomics and Proteomics of Oral Precancer Progression
    NIH/NIDCR R01DE015970May 1, 2004 - Mar 31, 2011
    Role: Principal Investigator
    Research Infrastructure Improvement for The UCLA SOD
    NIH/NIDCR R24DE015483Aug 1, 2003 - Jan 31, 2005
    Role: Principal Investigator
    p12CDK2-AP1 in Cell Cycle Control &Oral Carcinogenesis
    NIH/NIDCR R01DE014857Jul 1, 2003 - Apr 30, 2008
    Role: Principal Investigator
    UCLA Collaborative Oral Fluid Diagnostic Research Center
    NIH/NIDCR U01DE015018Sep 30, 2002 - Aug 31, 2006
    Role: Principal Investigator
    Molecular Predictors of Oral Premalignancy Progression
    NIH/NCI R21CA097771Feb 11, 2002 - Jan 31, 2004
    Role: Principal Investigator
    CELL CYCLE REGULATORS OF ORAL CANCER
    NIH/NIDCR P01DE012467Apr 1, 1998 - Mar 31, 2005
    Role: Co-Principal Investigator
    UCLA Dentist-Scientist &Oral Health-Scientist Training Program
    NIH/NIDCR T32DE007296Sep 1, 1996 - May 31, 2013
    Role: Principal Investigator
    SCIENTIFIC REVIEW &EVALUATION AWARD--NIDCR SPECIAL GRANT
    NIH/NIDCR U09DE011773Jul 15, 1995 - Jun 30, 2006
    Role: Principal Investigator
    SMALL INSTRUMENTATION GRANT
    NIH/NCI S15CA062317Sep 1, 1993 - Aug 31, 1994
    Role: Principal Investigator
    EOSINOPHIL AND EOSINOPHIL-DERIVED TGFS IN WOUND HEALING
    NIH/NIDCR R01DE010335Apr 1, 1993 - Mar 31, 1998
    Role: Principal Investigator
    RADIATION RESPONSIVENESS AND H3 MRNA IN HUMAN CANCER
    NIH/NCI R03CA056325Feb 5, 1992 - Jan 31, 1994
    Role: Principal Investigator
    SMALL INSTRUMENTATION GRANT
    NIH/NEI S15EY009450Aug 1, 1991 - Jul 31, 1992
    Role: Principal Investigator
    MOLECULAR DETERMINANTS OF ORAL CARCINOGENESIS
    NIH/NIDCR K04DE000318Apr 1, 1991 - Mar 31, 1996
    Role: Principal Investigator
    INSTITUTIONAL DENTIST SCIENTIST AWARD PROGRAM
    NIH/NIDCR K16DE000275Jul 1, 1990 - Jun 30, 2005
    Role: Co-Principal Investigator
    SMALL INSTRUMENTATION PROGRAM
    NIH/NIAMS S15AR040205Jun 1, 1989 - May 31, 1990
    Role: Principal Investigator
    CELLULAR/MOLECULAR DETERMINANTS IN ORAL CARCINOGENESIS
    NIH/NIDCR R01DE008680Aug 1, 1988 - Apr 30, 1999
    Role: Principal Investigator
    MOLECULAR DETERMINANTS OF ORAL CARCINOGENESIS
    NIH/NIDCR R29DE008680Aug 1, 1988 - Mar 31, 1995
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Li F, Yoshizawa JM, Kim KM, Kanjanapangka J, Grogan TR, Wang X, Elashoff DE, Ishikawa S, Chia D, Liao W, Akin D, Yan X, Lee MS, Choi R, Kim SM, Kang SY, Bae JM, Sohn TS, Lee JH, Choi MG, Min BH, Lee JH, Kim JJ, Kim Y, Kim S, Wong DTW. Discovery and Validation of Salivary Extracellular RNA Biomarkers for Noninvasive Detection of Gastric Cancer. Clin Chem. 2018 Aug 10. PMID: 30097497.
      View in: PubMed
    2. Kaczor-Urbanowicz KE, Trivedi HM, Lima PO, Camargo PM, Giannobile WV, Grogan TR, Gleber-Netto FO, Whiteman Y, Li F, Lee HJ, Dharia K, Aro K, Martin Carerras-Presas C, Amuthan S, Vartak M, Akin D, Al-Adbullah H, Bembey K, Klokkevold PR, Elashoff D, Barnes VM, Richter R, DeVizio W, Masters JG, Wong DTW. Salivary exRNA biomarkers to detect gingivitis and monitor disease regression. J Clin Periodontol. 2018 May 19. PMID: 29779262.
      View in: PubMed
    3. Li F, Kaczor-Urbanowicz KE, Sun J, Majem B, Lo HC, Kim Y, Koyano K, Liu Rao S, Young Kang S, Mi Kim S, Kim KM, Kim S, Chia D, Elashoff D, Grogan TR, Xiao X, Wong DTW. Characterization of Human Salivary Extracellular RNA by Next-generation Sequencing. Clin Chem. 2018 Apr 23. PMID: 29685897.
      View in: PubMed
    4. Kaczor-Urbanowicz KE, Kim Y, Li F, Galeev T, Kitchen RR, Gerstein M, Koyano K, Jeong SH, Wang X, Elashoff D, Kang SY, Kim SM, Kim K, Kim S, Chia D, Xiao X, Rozowsky J, Wong DTW. Novel approaches for bioinformatic analysis of salivary RNA sequencing data for development. Bioinformatics. 2018 01 01; 34(1):1-8. PMID: 28961734.
      View in: PubMed
    5. Nonaka T, Wong DTW. Saliva-Exosomics in Cancer: Molecular Characterization of Cancer-Derived Exosomes in Saliva. Enzymes. 2017; 42:125-151. PMID: 29054268.
      View in: PubMed
    6. Zhang Y, Sun J, Li F, Grogan TR, Vergara JL, Luan Q, Park MS, Chia D, Elashoff D, Joshipura KJ, Wong DTW. Salivary extracellular RNA biomarkers for insulin resistance detection in hispanics. Diabetes Res Clin Pract. 2017 Oct; 132:85-94. PMID: 28802700.
      View in: PubMed
    7. Aro K, Wei F, Wong DT, Tu M. Saliva Liquid Biopsy for Point-of-Care Applications. Front Public Health. 2017; 5:77. PMID: 28443278.
      View in: PubMed
    8. Huang WL, Chen YL, Yang SC, Ho CL, Wei F, Wong DT, Su WC, Lin CC. Liquid biopsy genotyping in lung cancer: ready for clinical utility? Oncotarget. 2017 Mar 14; 8(11):18590-18608. PMID: 28099915.
      View in: PubMed
    9. Wang C, Wang A, Wei F, Wong DTW, Tu M. Electric Field-Induced Disruption and Releasing Viable Content from Extracellular Vesicles. Methods Mol Biol. 2017; 1660:367-376. PMID: 28828672.
      View in: PubMed
    10. Wang A, Wang CP, Tu M, Wong DT. Oral Biofluid Biomarker Research: Current Status and Emerging Frontiers. Diagnostics (Basel). 2016 Dec 17; 6(4). PMID: 27999326.
      View in: PubMed
    11. Wang X, Kaczor-Urbanowicz KE, Wong DT. Salivary biomarkers in cancer detection. Med Oncol. 2017 Jan; 34(1):7. PMID: 27943101.
      View in: PubMed
    12. Kaczor-Urbanowicz KE, Martin Carreras-Presas C, Aro K, Tu M, Garcia-Godoy F, Wong DT. Saliva diagnostics - Current views and directions. Exp Biol Med (Maywood). 2017 03; 242(5):459-472. PMID: 27903834.
      View in: PubMed
    13. Katsiougiannis S, Chia D, Kim Y, Singh RP, Wong DT. Saliva exosomes from pancreatic tumor-bearing mice modulate NK cell phenotype and antitumor cytotoxicity. FASEB J. 2017 03; 31(3):998-1010. PMID: 27895106.
      View in: PubMed
    14. Kaczor-Urbanowicz KE, Martín Carreras-Presas C, Kaczor T, Tu M, Wei F, Garcia-Godoy F, Wong DT. Emerging technologies for salivaomics in cancer detection. J Cell Mol Med. 2017 04; 21(4):640-647. PMID: 27862926.
      View in: PubMed
    15. Katsiougiannis S, Wong DT. The Proteomics of Saliva in Sjögren's Syndrome. Rheum Dis Clin North Am. 2016 08; 42(3):449-56. PMID: 27431347.
      View in: PubMed
    16. Pu D, Liang H, Wei F, Akin D, Feng Z, Yan Q, Li Y, Zhen Y, Xu L, Dong G, Wan H, Dong J, Qiu X, Qin C, Zhu D, Wang X, Sun T, Zhang W, Li C, Tang X, Qiao Y, Wong DT, Zhou Q. Evaluation of a novel saliva-based epidermal growth factor receptor mutation detection for lung cancer: A pilot study. Thorac Cancer. 2016 Jul; 7(4):428-36. PMID: 27385985; PMCID: PMC4930962.
    17. Xiao H, Zhang Y, Kim Y, Kim S, Kim JJ, Kim KM, Yoshizawa J, Fan LY, Cao CX, Wong DT. Differential Proteomic Analysis of Human Saliva using Tandem Mass Tags Quantification for Gastric Cancer Detection. Sci Rep. 2016 Feb 25; 6:22165. PMID: 26911362; PMCID: PMC4766442.
    18. Gleber-Netto FO, Yakob M, Li F, Feng Z, Dai J, Kao HK, Chang YL, Chang KP, Wong DT. Salivary Biomarkers for Detection of Oral Squamous Cell Carcinoma in a Taiwanese Population. Clin Cancer Res. 2016 Jul 01; 22(13):3340-7. PMID: 26847061; PMCID: PMC4930722 [Available on 07/01/17].
    19. Zhang Y, Sun J, Lin CC, Abemayor E, Wang MB, Wong DT. The emerging landscape of salivary diagnostics. Periodontol 2000. 2016 Feb; 70(1):38-52. PMID: 26662481.
      View in: PubMed
    20. Tu M, Chia D, Wei F, Wong D. Liquid biopsy for detection of actionable oncogenic mutations in human cancers and electric field induced release and measurement liquid biopsy (eLB). Analyst. 2016 Jan 21; 141(2):393-402. PMID: 26645892; PMCID: PMC4701580.
    21. Matse JH, Yoshizawa J, Wang X, Elashoff D, Bolscher JG, Veerman EC, Leemans CR, Pegtel DM, Pegtel MD, Wong DT, Bloemena E. Human Salivary Micro-RNA in Patients with Parotid Salivary Gland Neoplasms. PLoS One. 2015; 10(11):e0142264. PMID: 26544193; PMCID: PMC4636154.
    22. Lin CC, Huang WL, Wei F, Su WC, Wong DT. Emerging platforms using liquid biopsy to detect EGFR mutations in lung cancer. Expert Rev Mol Diagn. 2015; 15(11):1427-40. PMID: 26420338; PMCID: PMC4889428 [Available on 09/30/16].
    23. Huang WL, Wei F, Wong DT, Lin CC, Su WC. The Emergent Landscape of Detecting EGFR Mutations Using Circulating Tumor DNA in Lung Cancer. Biomed Res Int. 2015; 2015:340732. PMID: 26448936; PMCID: PMC4584057.
    24. Chai YD, Zhang L, Yang Y, Su T, Charugundla P, Ai J, Messadi D, Wong DT, Hu S. Discovery of potential serum protein biomarkers for lymph node metastasis in oral cancer. Head Neck. 2016 Jan; 38(1):118-25. PMID: 25223295.
      View in: PubMed
    25. Lin X, Lo HC, Wong DT, Xiao X. Noncoding RNAs in human saliva as potential disease biomarkers. Front Genet. 2015; 6:175. PMID: 25999984; PMCID: PMC4423433.
    26. Majem B, Rigau M, Reventós J, Wong DT. Non-coding RNAs in saliva: emerging biomarkers for molecular diagnostics. Int J Mol Sci. 2015 Apr 17; 16(4):8676-98. PMID: 25898412; PMCID: PMC4425103.
    27. Wong DT. Salivary extracellular noncoding RNA: emerging biomarkers for molecular diagnostics. Clin Ther. 2015 Mar 01; 37(3):540-51. PMID: 25795433; PMCID: PMC4395471.
    28. Chiang SH, Thomas GA, Liao W, Grogan T, Buck RL, Fuentes L, Yakob M, Laughlin MJ, Schafer C, Nazmul-Hossain A, Wei F, Elashoff D, Slowey PD, Wong DT. RNAPro•SAL: a device for rapid and standardized collection of saliva RNA and proteins. Biotechniques. 2015 Feb; 58(2):69-76. PMID: 25652029; PMCID: PMC4377224.
    29. Wei F, Lin CC, Joon A, Feng Z, Troche G, Lira ME, Chia D, Mao M, Ho CL, Su WC, Wong DT. Noninvasive saliva-based EGFR gene mutation detection in patients with lung cancer. Am J Respir Crit Care Med. 2014 Nov 15; 190(10):1117-26. PMID: 25317990.
      View in: PubMed
    30. Yang J, Wei F, Schafer C, Wong DT. Detection of tumor cell-specific mRNA and protein in exosome-like microvesicles from blood and saliva. PLoS One. 2014; 9(11):e110641. PMID: 25397880; PMCID: PMC4232306.
    31. Deutsch O, Krief G, Konttinen YT, Zaks B, Wong DT, Aframian DJ, Palmon A. Identification of Sjögren's syndrome oral fluid biomarker candidates following high-abundance protein depletion. Rheumatology (Oxford). 2015 May; 54(5):884-90. PMID: 25339641.
      View in: PubMed
    32. Singh RP, Hasan S, Sharma S, Nagra S, Yamaguchi DT, Wong DT, Hahn BH, Hossain A. Th17 cells in inflammation and autoimmunity. Autoimmun Rev. 2014 Dec; 13(12):1174-81. PMID: 25151974.
      View in: PubMed
    33. Schafer CA, Schafer JJ, Yakob M, Lima P, Camargo P, Wong DT. Saliva diagnostics: utilizing oral fluids to determine health status. Monogr Oral Sci. 2014; 24:88-98. PMID: 24862597.
      View in: PubMed
    34. Yoshizawa JM, Schafer CA, Schafer JJ, Farrell JJ, Paster BJ, Wong DT. Salivary biomarkers: toward future clinical and diagnostic utilities. Clin Microbiol Rev. 2013 Oct; 26(4):781-91. PMID: 24092855; PMCID: PMC3811231.
    35. Lau C, Kim Y, Chia D, Spielmann N, Eibl G, Elashoff D, Wei F, Lin YL, Moro A, Grogan T, Chiang S, Feinstein E, Schafer C, Farrell J, Wong DT. Role of pancreatic cancer-derived exosomes in salivary biomarker development. J Biol Chem. 2013 Sep 13; 288(37):26888-97. PMID: 23880764; PMCID: PMC3772238.
    36. Matse JH, Yoshizawa J, Wang X, Elashoff D, Bolscher JG, Veerman EC, Bloemena E, Wong DT. Discovery and prevalidation of salivary extracellular microRNA biomarkers panel for the noninvasive detection of benign and malignant parotid gland tumors. Clin Cancer Res. 2013 Jun 01; 19(11):3032-8. PMID: 23575476.
      View in: PubMed
    37. Wong DT. Salivary diagnostics: the enabling factors for detecting oral diseases. J Calif Dent Assoc. 2013 Feb; 41(2):94-6. PMID: 23505754.
      View in: PubMed
    38. Wei F, Yang J, Wong DT. Detection of exosomal biomarker by electric field-induced release and measurement (EFIRM). Biosens Bioelectron. 2013 Jun 15; 44:115-21. PMID: 23402739; PMCID: PMC3809103.
    39. Yoshizawa JM, Wong DT. Salivary microRNAs and oral cancer detection. Methods Mol Biol. 2013; 936:313-24. PMID: 23007518; PMCID: PMC3630337.
    40. Bonne NJ, Wong DT. Salivary biomarker development using genomic, proteomic and metabolomic approaches. Genome Med. 2012; 4(10):82. PMID: 23114182; PMCID: PMC3580451.
    41. Kim JJ, Khalid O, Vo S, Sun HH, Wong DT, Kim Y. A novel regulatory factor recruits the nucleosome remodeling complex to wingless integrated (Wnt) signaling gene promoters in mouse embryonic stem cells. J Biol Chem. 2012 Nov 30; 287(49):41103-17. PMID: 23074223; PMCID: PMC3510811.
    42. Wong DT. Salivaomics. J Am Dent Assoc. 2012 Oct; 143(10 Suppl):19S-24S. PMID: 23034834.
      View in: PubMed
    43. Kim JK, Zhou H, Nabili V, Wang MB, Abemayor E, Wong DT. Utility of multiple sampling in reducing variation of salivary interleukin-8 and interleukin-1ß mRNA levels in healthy adults. Head Neck. 2013 Jul; 35(7):968-73. PMID: 22807130.
      View in: PubMed
    44. Wong DT. Salivary diagnostics. Oper Dent. 2012 Nov-Dec; 37(6):562-70. PMID: 22788724.
      View in: PubMed
    45. Spielmann N, Ilsley D, Gu J, Lea K, Brockman J, Heater S, Setterquist R, Wong DT. The human salivary RNA transcriptome revealed by massively parallel sequencing. Clin Chem. 2012 Sep; 58(9):1314-21. PMID: 22773539.
      View in: PubMed
    46. Deshpande AM, Khalid O, Kim JJ, Kim Y, Lindgren A, Clark AT, Wong DT. Cdk2ap2 is a novel regulator for self-renewal of murine embryonic stem cells. Stem Cells Dev. 2012 Nov 01; 21(16):3010-8. PMID: 22548356; PMCID: PMC3475145.
    47. Zhang L, Xiao H, Zhou H, Santiago S, Lee JM, Garon EB, Yang J, Brinkmann O, Yan X, Akin D, Chia D, Elashoff D, Park NH, Wong DTW. Development of transcriptomic biomarker signature in human saliva to detect lung cancer. Cell Mol Life Sci. 2012 Oct; 69(19):3341-3350. PMID: 22689099; PMCID: PMC4121486.
    48. Ai JY, Smith B, Wong DT. Bioinformatics advances in saliva diagnostics. Int J Oral Sci. 2012 Jun; 4(2):85-7. PMID: 22699264; PMCID: PMC3412667.
    49. Brinkmann O, Spielmann N, Wong DT. Salivary diagnostics: moving to the next level. Dent Today. 2012 Jun; 31(6):54, 56-7; quiz 58-9. PMID: 22746063.
      View in: PubMed
    50. Lau CS, Wong DT. Breast cancer exosome-like microvesicles and salivary gland cells interplay alters salivary gland cell-derived exosome-like microvesicles in vitro. PLoS One. 2012; 7(3):e33037. PMID: 22448232; PMCID: PMC3308964.
    51. Xiao H, Wong DT. Method development for proteome stabilization in human saliva. Anal Chim Acta. 2012 Apr 13; 722:63-9. PMID: 22444535.
      View in: PubMed
    52. Xiao H, Wong DT. Proteomic analysis of microvesicles in human saliva by gel electrophoresis with liquid chromatography-mass spectrometry. Anal Chim Acta. 2012 Apr 20; 723:61-7. PMID: 22444574.
      View in: PubMed
    53. Elashoff D, Zhou H, Reiss J, Wang J, Xiao H, Henson B, Hu S, Arellano M, Sinha U, Le A, Messadi D, Wang M, Nabili V, Lingen M, Morris D, Randolph T, Feng Z, Akin D, Kastratovic DA, Chia D, Abemayor E, Wong DT. Prevalidation of salivary biomarkers for oral cancer detection. Cancer Epidemiol Biomarkers Prev. 2012 Apr; 21(4):664-72. PMID: 22301830; PMCID: PMC3319329.
    54. Wei F, Wong DT. Point-of-care platforms for salivary diagnostics. Chin J Dent Res. 2012; 15(1):7-15. PMID: 22866276.
      View in: PubMed
    55. Lee YH, Kim JH, Zhou H, Kim BW, Wong DT. Salivary transcriptomic biomarkers for detection of ovarian cancer: for serous papillary adenocarcinoma. J Mol Med (Berl). 2012 Apr; 90(4):427-34. PMID: 22095100.
      View in: PubMed
    56. Xiao H, Zhang L, Zhou H, Lee JM, Garon EB, Wong DT. Proteomic analysis of human saliva from lung cancer patients using two-dimensional difference gel electrophoresis and mass spectrometry. Mol Cell Proteomics. 2012 Feb; 11(2):M111.012112. PMID: 22096114; PMCID: PMC3277759.
    57. Farrell JJ, Zhang L, Zhou H, Chia D, Elashoff D, Akin D, Paster BJ, Joshipura K, Wong DT. Variations of oral microbiota are associated with pancreatic diseases including pancreatic cancer. Gut. 2012 Apr; 61(4):582-8. PMID: 21994333; PMCID: PMC3705763.
    58. Wong DT. Salivary diagnostics: scientific and clinical frontiers. Adv Dent Res. 2011 Oct; 23(4):350-2. PMID: 21917744.
      View in: PubMed
    59. Lee YH, Zhou H, Reiss JK, Yan X, Zhang L, Chia D, Wong DT. Direct saliva transcriptome analysis. Clin Chem. 2011 Sep; 57(9):1295-302. PMID: 21791578.
      View in: PubMed
    60. Sharma S, Liao W, Zhou X, Wong DT, Lichtenstein A. Exon 11 skipping of E-cadherin RNA downregulates its expression in head and neck cancer cells. Mol Cancer Ther. 2011 Sep; 10(9):1751-9. PMID: 21764905; PMCID: PMC3170438.
    61. Hu S, Vissink A, Arellano M, Roozendaal C, Zhou H, Kallenberg CG, Wong DT. Identification of autoantibody biomarkers for primary Sjögren's syndrome using protein microarrays. Proteomics. 2011 Apr; 11(8):1499-507. PMID: 21413148; PMCID: PMC3209962.
    62. Brinkmann O, Zhang L, Giannobile WV, Wong DT. Salivary biomarkers for periodontal disease diagnostics. Expert Opin Med Diagn. 2011 Jan; 5(1):25-35. PMID: 23484474.
      View in: PubMed
    63. Brinkmann O, Wong DT. Salivary transcriptome biomarkers in oral squamous cell cancer detection. Adv Clin Chem. 2011; 55:21-34. PMID: 22126022.
      View in: PubMed
    64. Zhang L, Xiao H, Karlan S, Zhou H, Gross J, Elashoff D, Akin D, Yan X, Chia D, Karlan B, Wong DT. Discovery and preclinical validation of salivary transcriptomic and proteomic biomarkers for the non-invasive detection of breast cancer. PLoS One. 2010 Dec 31; 5(12):e15573. PMID: 21217834; PMCID: PMC3013113.
    65. Spielmann N, Wong DT. Saliva: diagnostics and therapeutic perspectives. Oral Dis. 2011 May; 17(4):345-54. PMID: 21122035; PMCID: PMC3056919.
    66. Brinkmann O, Kastratovic DA, Dimitrijevic MV, Konstantinovic VS, Jelovac DB, Antic J, Nesic VS, Markovic SZ, Martinovic ZR, Akin D, Spielmann N, Zhou H, Wong DT. Oral squamous cell carcinoma detection by salivary biomarkers in a Serbian population. Oral Oncol. 2011 Jan; 47(1):51-5. PMID: 21109482; PMCID: PMC3032819.
    67. Ai J, Smith B, Wong DT. Saliva Ontology: an ontology-based framework for a Salivaomics Knowledge Base. BMC Bioinformatics. 2010 Jun 03; 11:302. PMID: 20525291; PMCID: PMC2898059.
    68. Sharma S, Rasool HI, Palanisamy V, Mathisen C, Schmidt M, Wong DT, Gimzewski JK. Structural-mechanical characterization of nanoparticle exosomes in human saliva, using correlative AFM, FESEM, and force spectroscopy. ACS Nano. 2010 Apr 27; 4(4):1921-6. PMID: 20218655; PMCID: PMC2866049.
    69. Ryan CM, Souda P, Halgand F, Wong DT, Loo JA, Faull KF, Whitelegge JP. Confident assignment of intact mass tags to human salivary cystatins using top-down Fourier-transform ion cyclotron resonance mass spectrometry. J Am Soc Mass Spectrom. 2010 Jun; 21(6):908-17. PMID: 20189825; PMCID: PMC2873128.
    70. Halgand F, Zabrouskov V, Bassilian S, Souda P, Wong DT, Loo JA, Faull KF, Whitelegge JP. Micro-heterogeneity of human saliva Peptide P-C characterized by high-resolution top-down Fourier-transform mass spectrometry. J Am Soc Mass Spectrom. 2010 May; 21(5):868-77. PMID: 20185333.
      View in: PubMed
    71. Hu S, Jiang J, Wong DT. Proteomic analysis of saliva: 2D gel electrophoresis, LC-MS/MS, and Western blotting. Methods Mol Biol. 2010; 666:31-41. PMID: 20717776; PMCID: PMC3209956.
    72. Zhang L, Farrell JJ, Zhou H, Elashoff D, Akin D, Park NH, Chia D, Wong DT. Salivary transcriptomic biomarkers for detection of resectable pancreatic cancer. Gastroenterology. 2010 Mar; 138(3):949-57.e1-7. PMID: 19931263; PMCID: PMC2831159.
    73. Wei F, Liao W, Xu Z, Yang Y, Wong DT, Ho CM. Bio/abiotic interface constructed from nanoscale DNA dendrimer and conducting polymer for ultrasensitive biomolecular diagnosis. Small. 2009 Aug 03; 5(15):1784-90. PMID: 19384878; PMCID: PMC2800851.
    74. Kim Y, Deshpande A, Dai Y, Kim JJ, Lindgren A, Conway A, Clark AT, Wong DT. Cyclin-dependent kinase 2-associating protein 1 commits murine embryonic stem cell differentiation through retinoblastoma protein regulation. J Biol Chem. 2009 Aug 28; 284(35):23405-14. PMID: 19564334; PMCID: PMC2749114.
    75. Gao K, Zhou H, Zhang L, Lee JW, Zhou Q, Hu S, Wolinsky LE, Farrell J, Eibl G, Wong DT. Systemic disease-induced salivary biomarker profiles in mouse models of melanoma and non-small cell lung cancer. PLoS One. 2009 Jun 11; 4(6):e5875. PMID: 19517020; PMCID: PMC2691577.
    76. Wei F, Patel P, Liao W, Chaudhry K, Zhang L, Arellano-Garcia M, Hu S, Elashoff D, Zhou H, Shukla S, Shah F, Ho CM, Wong DT. Electrochemical sensor for multiplex biomarkers detection. Clin Cancer Res. 2009 Jul 01; 15(13):4446-52. PMID: 19509137; PMCID: PMC2799532.
    77. Arellano M, Jiang J, Zhou X, Zhang L, Ye H, Wong DT, Hu S. Current advances in identification of cancer biomarkers in saliva. Front Biosci (Schol Ed). 2009 Jun 01; 1:296-303. PMID: 19482703.
      View in: PubMed
    78. Kim Y, McBride J, Kimlin L, Pae EK, Deshpande A, Wong DT. Targeted inactivation of p12, CDK2 associating protein 1, leads to early embryonic lethality. PLoS One. 2009; 4(2):e4518. PMID: 19229340; PMCID: PMC2641017.
    79. Hu S, Wong DT. Lectin microarray. Proteomics Clin Appl. 2009 Feb; 3(2):148-54. PMID: 21132067.
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    80. Yan W, Apweiler R, Balgley BM, Boontheung P, Bundy JL, Cargile BJ, Cole S, Fang X, Gonzalez-Begne M, Griffin TJ, Hagen F, Hu S, Wolinsky LE, Lee CS, Malamud D, Melvin JE, Menon R, Mueller M, Qiao R, Rhodus NL, Sevinsky JR, States D, Stephenson JL, Than S, Yates JR, Yu W, Xie H, Xie Y, Omenn GS, Loo JA, Wong DT. Systematic comparison of the human saliva and plasma proteomes. Proteomics Clin Appl. 2009 Jan 01; 3(1):116-134. PMID: 19898684.
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    81. Hu S, Zhou M, Jiang J, Wang J, Elashoff D, Gorr S, Michie SA, Spijkervet FK, Bootsma H, Kallenberg CG, Vissink A, Horvath S, Wong DT. Systems biology analysis of Sjögren's syndrome and mucosa-associated lymphoid tissue lymphoma in parotid glands. Arthritis Rheum. 2009 Jan; 60(1):81-92. PMID: 19116902; PMCID: PMC2718690.
    82. Giannobile WV, Beikler T, Kinney JS, Ramseier CA, Morelli T, Wong DT. Saliva as a diagnostic tool for periodontal disease: current state and future directions. Periodontol 2000. 2009; 50:52-64. PMID: 19388953.
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    83. Zhang L, Xiao H, Wong DT. Salivary biomarkers for clinical applications. Mol Diagn Ther. 2009; 13(4):245-59. PMID: 19712004.
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    84. Zhang L, Henson BS, Camargo PM, Wong DT. The clinical value of salivary biomarkers for periodontal disease. Periodontol 2000. 2009; 51:25-37. PMID: 19878467.
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    85. Deshpande AM, Dai YS, Kim Y, Kim J, Kimlin L, Gao K, Wong DT. Cdk2ap1 is required for epigenetic silencing of Oct4 during murine embryonic stem cell differentiation. J Biol Chem. 2009 Mar 06; 284(10):6043-7. PMID: 19117947; PMCID: PMC2649091.
    86. Ramachandran P, Boontheung P, Pang E, Yan W, Wong DT, Loo JA. Comparison of N-linked Glycoproteins in Human Whole Saliva, Parotid, Submandibular, and Sublingual Glandular Secretions Identified using Hydrazide Chemistry and Mass Spectrometry. Clin Proteomics. 2008 Dec; 4(3-4):80-104. PMID: 21960768.
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    87. Jiang J, Park NJ, Hu S, Wong DT. A universal pre-analytic solution for concurrent stabilization of salivary proteins, RNA and DNA at ambient temperature. Arch Oral Biol. 2009 Mar; 54(3):268-73. PMID: 19047016; PMCID: PMC2674508.
    88. Hu S, Arellano M, Boontheung P, Wang J, Zhou H, Jiang J, Elashoff D, Wei R, Loo JA, Wong DT. Salivary proteomics for oral cancer biomarker discovery. Clin Cancer Res. 2008 Oct 01; 14(19):6246-52. PMID: 18829504; PMCID: PMC2877125.
    89. Wei F, Wang J, Liao W, Zimmermann BG, Wong DT, Ho CM. Electrochemical detection of low-copy number salivary RNA based on specific signal amplification with a hairpin probe. Nucleic Acids Res. 2008 Jun; 36(11):e65. PMID: 18487624; PMCID: PMC2441804.
    90. Brooks MN, Wang J, Li Y, Zhang R, Elashoff D, Wong DT. Salivary protein factors are elevated in breast cancer patients. Mol Med Rep. 2008 May-Jun; 1(3):375-8. PMID: 19844594.
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    91. Deshpande AM, Wong DT. Molecular mechanisms of head and neck cancer. Expert Rev Anticancer Ther. 2008 May; 8(5):799-809. PMID: 18471051; PMCID: PMC2709830.
    92. Tan W, Sabet L, Li Y, Yu T, Klokkevold PR, Wong DT, Ho CM. Optical protein sensor for detecting cancer markers in saliva. Biosens Bioelectron. 2008 Oct 15; 24(2):266-71. PMID: 18479906; PMCID: PMC2584973.
    93. Denny P, Hagen FK, Hardt M, Liao L, Yan W, Arellanno M, Bassilian S, Bedi GS, Boontheung P, Cociorva D, Delahunty CM, Denny T, Dunsmore J, Faull KF, Gilligan J, Gonzalez-Begne M, Halgand F, Hall SC, Han X, Henson B, Hewel J, Hu S, Jeffrey S, Jiang J, Loo JA, Ogorzalek Loo RR, Malamud D, Melvin JE, Miroshnychenko O, Navazesh M, Niles R, Park SK, Prakobphol A, Ramachandran P, Richert M, Robinson S, Sondej M, Souda P, Sullivan MA, Takashima J, Than S, Wang J, Whitelegge JP, Witkowska HE, Wolinsky L, Xie Y, Xu T, Yu W, Ytterberg J, Wong DT, Yates JR, Fisher SJ. The proteomes of human parotid and submandibular/sublingual gland salivas collected as the ductal secretions. J Proteome Res. 2008 May; 7(5):1994-2006. PMID: 18361515; PMCID: PMC2839126.
    94. Hu Z, Zimmermann BG, Zhou H, Wang J, Henson BS, Yu W, Elashoff D, Krupp G, Wong DT. Exon-level expression profiling: a comprehensive transcriptome analysis of oral fluids. Clin Chem. 2008 May; 54(5):824-32. PMID: 18356245; PMCID: PMC2799536.
    95. Segal A, Wong DT. Salivary diagnostics: enhancing disease detection and making medicine better. Eur J Dent Educ. 2008 Feb; 12 Suppl 1:22-9. PMID: 18289265; PMCID: PMC2674509.
    96. Zhang L, Jiang J, Arellano M, Zhang L, Yan X, Wong DT, Hu S. Quantification of Serum Proteins of Metastatic Oral Cancer Patients Using LC-MS/MS and iTRAQ Labeling. Open Proteomics J. 2008; 1:72-78. PMID: 20485468.
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    97. Zimmermann BG, Wong DT. Salivary mRNA targets for cancer diagnostics. Oral Oncol. 2008 May; 44(5):425-9. PMID: 18061522; PMCID: PMC2408659.
    98. Whitelegge JP, Zabrouskov V, Halgand F, Souda P, Bassilian S, Yan W, Wolinsky L, Loo JA, Wong DT, Faull KF. Protein-Sequence Polymorphisms and Post-translational Modifications in Proteins from Human Saliva using Top-Down Fourier-transform Ion Cyclotron Resonance Mass Spectrometry. Int J Mass Spectrom. 2007 Dec 01; 268(2-3):190-197. PMID: 19050733.
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    99. Hu S, Wang J, Meijer J, Ieong S, Xie Y, Yu T, Zhou H, Henry S, Vissink A, Pijpe J, Kallenberg C, Elashoff D, Loo JA, Wong DT. Salivary proteomic and genomic biomarkers for primary Sjögren's syndrome. Arthritis Rheum. 2007 Nov; 56(11):3588-600. PMID: 17968930; PMCID: PMC2856841.
    100. Hu S, Yen Y, Ann D, Wong DT. Implications of salivary proteomics in drug discovery and development: a focus on cancer drug discovery. Drug Discov Today. 2007 Nov; 12(21-22):911-6. PMID: 17993408.
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    101. Hu S, Wong DT. Oral cancer proteomics. Curr Opin Mol Ther. 2007 Oct; 9(5):467-76. PMID: 17932810.
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    102. Hu S, Loo JA, Wong DT. Human saliva proteome analysis and disease biomarker discovery. Expert Rev Proteomics. 2007 Aug; 4(4):531-8. PMID: 17705710.
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    103. Hu S, Yu T, Xie Y, Yang Y, Li Y, Zhou X, Tsung S, Loo RR, Loo JR, Wong DT. Discovery of oral fluid biomarkers for human oral cancer by mass spectrometry. Cancer Genomics Proteomics. 2007 Mar-Apr; 4(2):55-64. PMID: 17804867.
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    104. Hu S, Loo JA, Wong DT. Human saliva proteome analysis. Ann N Y Acad Sci. 2007 Mar; 1098:323-9. PMID: 17435138.
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    105. Zimmermann BG, Park NJ, Wong DT. Genomic targets in saliva. Ann N Y Acad Sci. 2007 Mar; 1098:184-91. PMID: 17435127; PMCID: PMC2910758.
    106. Peng H, Shintani S, Kim Y, Wong DT. Loss of p12CDK2-AP1 expression in human oral squamous cell carcinoma with disrupted transforming growth factor-beta-Smad signaling pathway. Neoplasia. 2006 Dec; 8(12):1028-36. PMID: 17217620; PMCID: PMC1783720.
    107. Hu S, Loo JA, Wong DT. Human body fluid proteome analysis. Proteomics. 2006 Dec; 6(23):6326-53. PMID: 17083142; PMCID: PMC2910092.
    108. Zhou X, Temam S, Oh M, Pungpravat N, Huang BL, Mao L, Wong DT. Global expression-based classification of lymph node metastasis and extracapsular spread of oral tongue squamous cell carcinoma. Neoplasia. 2006 Nov; 8(11):925-32. PMID: 17132224; PMCID: PMC1716013.
    109. Park NJ, Zhou X, Yu T, Brinkman BM, Zimmermann BG, Palanisamy V, Wong DT. Characterization of salivary RNA by cDNA library analysis. Arch Oral Biol. 2007 Jan; 52(1):30-5. PMID: 17052683; PMCID: PMC2743855.
    110. Ramachandran P, Boontheung P, Xie Y, Sondej M, Wong DT, Loo JA. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. J Proteome Res. 2006 Jun; 5(6):1493-503. PMID: 16740002.
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    111. Wong DT. Towards a simple, saliva-based test for the detection of oral cancer 'oral fluid (saliva), which is the mirror of the body, is a perfect medium to be explored for health and disease surveillance'. Expert Rev Mol Diagn. 2006 May; 6(3):267-72. PMID: 16706730.
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    112. Brinkman BM, Wong DT. Disease mechanism and biomarkers of oral squamous cell carcinoma. Curr Opin Oncol. 2006 May; 18(3):228-33. PMID: 16552233.
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    113. Wong DT. Salivary diagnostics. J Calif Dent Assoc. 2006 Apr; 34(4):283-5. PMID: 16900985.
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    114. Wong DT. Salivary diagnostics for oral cancer. J Calif Dent Assoc. 2006 Apr; 34(4):303-8. PMID: 16900988.
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    115. Nguyen S, Wong DT. Cultural, behavioral, social, and psychological perceptions of saliva: relevance to clinical diagnostics. J Calif Dent Assoc. 2006 Apr; 34(4):317-22. PMID: 16900990.
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    116. Wong DT. Salivary diagnostics powered by nanotechnologies, proteomics and genomics. J Am Dent Assoc. 2006 Mar; 137(3):313-21. PMID: 16570464.
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    117. Forde MD, Koka S, Eckert SE, Carr AB, Wong DT. Systemic assessments utilizing saliva: part 1 general considerations and current assessments. Int J Prosthodont. 2006 Jan-Feb; 19(1):43-52. PMID: 16479760.
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    118. Zhou X, Yu T, Cole SW, Wong DT. Advancement in characterization of genomic alterations for improved diagnosis, treatment and prognostics in cancer. Expert Rev Mol Diagn. 2006 Jan; 6(1):39-50. PMID: 16359266.
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    119. Zhou X, Temam S, Chen Z, Ye H, Mao L, Wong DT. Allelic imbalance analysis of oral tongue squamous cell carcinoma by high-density single nucleotide polymorphism arrays using whole-genome amplified DNA. Hum Genet. 2005 Dec; 118(3-4):504-7. PMID: 16193324.
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    120. Yang CY, Brooks E, Li Y, Denny P, Ho CM, Qi F, Shi W, Wolinsky L, Wu B, Wong DT, Montemagno CD. Detection of picomolar levels of interleukin-8 in human saliva by SPR. Lab Chip. 2005 Oct; 5(10):1017-23. PMID: 16175255.
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    121. Gu F, Lux R, Du-Thumm L, Stokes I, Kreth J, Anderson MH, Wong DT, Wolinsky L, Sullivan R, Shi W. In situ and non-invasive detection of specific bacterial species in oral biofilms using fluorescently labeled monoclonal antibodies. J Microbiol Methods. 2005 Aug; 62(2):145-60. PMID: 15935497.
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    122. Zhou X, Jordan RC, Li Y, Huang BL, Wong DT. Frequent allelic imbalances at 8p and 11q22 in oral and oropharyngeal epithelial dysplastic lesions. Cancer Genet Cytogenet. 2005 Aug; 161(1):86-9. PMID: 16080964.
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    123. Figueiredo ML, Kim Y, St John MA, Wong DT. p12CDK2-AP1 gene therapy strategy inhibits tumor growth in an in vivo mouse model of head and neck cancer. Clin Cancer Res. 2005 May 15; 11(10):3939-48. PMID: 15897596.
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    124. Zhou X, Rao NP, Cole SW, Mok SC, Chen Z, Wong DT. Progress in concurrent analysis of loss of heterozygosity and comparative genomic hybridization utilizing high density single nucleotide polymorphism arrays. Cancer Genet Cytogenet. 2005 May; 159(1):53-7. PMID: 15860358.
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    125. Kim Y, Ohyama H, Patel V, Figueiredo M, Wong DT. Mutation of Cys105 inhibits dimerization of p12CDK2-AP1 and its growth suppressor effect. J Biol Chem. 2005 Jun 17; 280(24):23273-9. PMID: 15840587.
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    126. Hu S, Xie Y, Ramachandran P, Ogorzalek Loo RR, Li Y, Loo JA, Wong DT. Large-scale identification of proteins in human salivary proteome by liquid chromatography/mass spectrometry and two-dimensional gel electrophoresis-mass spectrometry. Proteomics. 2005 Apr; 5(6):1714-28. PMID: 15800970.
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    127. Kim Y, McBride J, Zhang R, Zhou X, Wong DT. p12(CDK2-AP1) mediates DNA damage responses induced by cisplatin. Oncogene. 2005 Jan 13; 24(3):407-18. PMID: 15543230.
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    128. Kim Y, Shintani S, Kohno Y, Zhang R, Wong DT. Cyclin G2 dysregulation in human oral cancer. Cancer Res. 2004 Dec 15; 64(24):8980-6. PMID: 15604262.
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    129. Li Y, St John MA, Zhou X, Kim Y, Sinha U, Jordan RC, Eisele D, Abemayor E, Elashoff D, Park NH, Wong DT. Salivary transcriptome diagnostics for oral cancer detection. Clin Cancer Res. 2004 Dec 15; 10(24):8442-50. PMID: 15623624.
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    130. Hu S, Denny P, Denny P, Xie Y, Loo JA, Wolinsky LE, Li Y, McBride J, Ogorzalek Loo RR, Navazesh M, Wong DT. Differentially expressed protein markers in human submandibular and sublingual secretions. Int J Oncol. 2004 Nov; 25(5):1423-30. PMID: 15492834.
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    131. Zhou X, Mok SC, Chen Z, Li Y, Wong DT. Concurrent analysis of loss of heterozygosity (LOH) and copy number abnormality (CNA) for oral premalignancy progression using the Affymetrix 10K SNP mapping array. Hum Genet. 2004 Sep; 115(4):327-30. PMID: 15290239.
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    132. St John MA, Li Y, Zhou X, Denny P, Ho CM, Montemagno C, Shi W, Qi F, Wu B, Sinha U, Jordan R, Wolinsky L, Park NH, Liu H, Abemayor E, Wong DT. Interleukin 6 and interleukin 8 as potential biomarkers for oral cavity and oropharyngeal squamous cell carcinoma. Arch Otolaryngol Head Neck Surg. 2004 Aug; 130(8):929-35. PMID: 15313862.
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    133. Zhou X, Cole SW, Hu S, Wong DT. Detection of DNA copy number abnormality by microarray expression analysis. Hum Genet. 2004 Apr; 114(5):464-7. PMID: 14872338.
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