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Mayer Emeran

TitleDirector
InstitutionUniversity of California Los Angeles
DepartmentUCLA Gail and Gerald Oppenheimer Family Center for Neurobiology of Stress
Address10833 Le Conte Ave
CHS 42-210 MC 737818
Los Angeles CA 90095
Phone310-206-6279
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    Other Positions
    TitleProfessor

    TitleProfessor

    TitleProfessor

    TitleCo-Director

    TitleProfessor


    Collapse Research 
    Collapse Research Activities and Funding
    Neurobiological mechanisms underlying effectiveness of CBT in IBS patients
    NIH/NIDDK R01DK096606Sep 15, 2012 - Aug 31, 2016
    Role: Principal Investigator
    MAPP Research Network Second Phase
    NIH/NIDDK U01DK082370Sep 15, 2008 - Jun 30, 2019
    Role: Principal Investigator
    Mind/Brain/Body Interactions in Stress-Related Disorders
    NIH/NCCIH R24AT002681Sep 15, 2004 - Jul 31, 2010
    Role: Principal Investigator
    Center for Neurovisceral Sciences & Women's Health
    NIH/NIDDK P50DK064539Sep 30, 2002 - Aug 31, 2017
    Role: Principal Investigator
    Peripheral NMDA Receptors in Visceral Nociception
    NIH/NIDDK R01DK058173Jul 1, 2000 - Aug 31, 2010
    Role: Co-Principal Investigator
    Perception and Modulation of Visceral Sensation
    NIH/NIDDK R01DK048351Sep 30, 1996 - Jul 31, 2020
    Role: Principal Investigator
    CONTRACTION COUPLING IN COLONIC MUSCLE
    NIH/NIDDK R01DK040919Jul 1, 1989 - Nov 30, 1999
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Schrepf A, Naliboff B, Williams DA, Stephens-Shields AJ, Landis JR, Gupta A, Mayer E, Rodriguez LV, Lai H, Luo Y, Bradley C, Kreder K, Lutgendorf SK. Adverse Childhood Experiences and Symptoms of Urologic Chronic Pelvic Pain Syndrome: A Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network Study. Ann Behav Med. 2018 Sep 13; 52(10):865-877. PMID: 30212850.
      View in: PubMed
    2. Osadchiy V, Labus JS, Gupta A, Jacobs J, Ashe-McNalley C, Hsiao EY, Mayer EA. Correlation of tryptophan metabolites with connectivity of extended central reward network in healthy subjects. PLoS One. 2018; 13(8):e0201772. PMID: 30080865.
      View in: PubMed
    3. Martin CR, Osadchiy V, Kalani A, Mayer EA. The Brain-Gut-Microbiome Axis. Cell Mol Gastroenterol Hepatol. 2018; 6(2):133-148. PMID: 30023410.
      View in: PubMed
    4. Bonfiglio F, Zheng T, Garcia-Etxebarria K, Hadizadeh F, Bujanda L, Bresso F, Agreus L, Andreasson A, Dlugosz A, Lindberg G, Schmidt PT, Karling P, Ohlsson B, Simren M, Walter S, Nardone G, Cuomo R, Usai-Satta P, Galeazzi F, Neri M, Portincasa P, Bellini M, Barbara G, Latiano A, Hübenthal M, Thijs V, Netea MG, Jonkers D, Chang L, Mayer EA, Wouters MM, Boeckxstaens G, Camilleri M, Franke A, Zhernakova A, D'Amato M. Female-specific Association Between Variants on Chromosome 9 and Self-reported Diagnosis of Irritable Bowel Syndrome. Gastroenterology. 2018 Apr 04. PMID: 29626450.
      View in: PubMed
    5. Videlock EJ, Mahurkar-Joshi S, Hoffman JM, Iliopoulos D, Pothoulakis C, Mayer EA, Chang L. Sigmoid colon mucosal gene expression supports alterations of neuronal signaling in irritable bowel syndrome with constipation. Am J Physiol Gastrointest Liver Physiol. 2018 Mar 22. PMID: 29565640.
      View in: PubMed
    6. Woodworth DC, Holly LT, Mayer EA, Salamon N, Ellingson BM. Alterations in Cortical Thickness and Subcortical Volume are Associated With Neurological Symptoms and Neck Pain in Patients With Cervical Spondylosis. Neurosurgery. 2018 Mar 14. PMID: 29548020.
      View in: PubMed
    7. Garcia-Etxebarria K, Zheng T, Bonfiglio F, Bujanda L, Dlugosz A, Lindberg G, Schmidt PT, Karling P, Ohlsson B, Simren M, Walter S, Nardone G, Cuomo R, Usai-Satta P, Galeazzi F, Neri M, Portincasa P, Bellini M, Barbara G, Jonkers D, Eswaran S, Chey WD, Kashyap P, Chang L, Mayer EA, Wouters MM, Boeckxstaens G, Camilleri M, Franke A, D'Amato M. Increased Prevalence of Rare Sucrase-isomaltase (SI) Pathogenic Variants in Irritable Bowel Syndrome Patients. Clin Gastroenterol Hepatol. 2018 Feb 21. PMID: 29408290.
      View in: PubMed
    8. Gupta A, Woodworth DC, Ellingson BM, Rapkin AJ, Naliboff B, Kilpatrick LA, Stains J, Masghati S, Tillisch K, Mayer EA, Labus JS. Disease-Related Microstructural Differences in the Brain in Women With Provoked Vestibulodynia. J Pain. 2018 May; 19(5):528.e1-528.e15. PMID: 29391213.
      View in: PubMed
    9. Addante R, Naliboff B, Shih W, Presson AP, Tillisch K, Mayer EA, Chang L. Predictors of Health-related Quality of Life in Irritable Bowel Syndrome Patients Compared With Healthy Individuals. J Clin Gastroenterol. 2018 Jan 18. PMID: 29351154.
      View in: PubMed
    10. Mayer EA. The Role of Gut-Brain Interactions in Influencing Symptoms of Irritable Bowel Syndrome. Gastroenterol Hepatol (N Y). 2018 Jan; 14(1):44-46. PMID: 29491761.
      View in: PubMed
    11. Gupta A, Mayer EA, Labus JS, Bhatt RR, Ju T, Love A, Bal A, Tillisch K, Naliboff B, Sanmiguel CP, Kilpatrick LA. Sex Commonalities and Differences in Obesity-Related Alterations in Intrinsic Brain Activity and Connectivity. Obesity (Silver Spring). 2018 Feb; 26(2):340-350. PMID: 29280306.
      View in: PubMed
    12. Strege PR, Mazzone A, Bernard CE, Neshatian L, Gibbons SJ, Saito YA, Tester DJ, Calvert ML, Mayer EA, Chang L, Ackerman MJ, Beyder A, Farrugia G. Irritable bowel syndrome patients have SCN5A channelopathies that lead to decreased NaV1.5 current and mechanosensitivity. Am J Physiol Gastrointest Liver Physiol. 2018 Apr 01; 314(4):G494-G503. PMID: 29167113.
      View in: PubMed
    13. Zucker NL, Kragel PA, Wagner HR, Keeling L, Mayer E, Wang J, Kang MS, Merwin R, Simmons WK, LaBar KS. The Clinical Significance of Posterior Insular Volume in Adolescent Anorexia Nervosa. Psychosom Med. 2017 Nov/Dec; 79(9):1025-1035. PMID: 28691997.
      View in: PubMed
    14. Wohlfarth C, Schmitteckert S, Härtle JD, Houghton LA, Dweep H, Fortea M, Assadi G, Braun A, Mederer T, Pöhner S, Becker PP, Fischer C, Granzow M, Mönnikes H, Mayer EA, Sayuk G, Boeckxstaens G, Wouters MM, Simrén M, Lindberg G, Ohlsson B, Schmidt PT, Dlugosz A, Agreus L, Andreasson A, D'Amato M, Burwinkel B, Bermejo JL, Röth R, Lasitschka F, Vicario M, Metzger M, Santos J, Rappold GA, Martinez C, Niesler B. miR-16 and miR-103 impact 5-HT4 receptor signalling and correlate with symptom profile in irritable bowel syndrome. Sci Rep. 2017 Oct 31; 7(1):14680. PMID: 29089619.
      View in: PubMed
    15. Mayer EA, Hsiao EY. The Gut and Its Microbiome as Related to Central Nervous System Functioning and Psychological Well-being: Introduction to the Special Issue of Psychosomatic Medicine. Psychosom Med. 2017 Oct; 79(8):844-846. PMID: 28976454.
      View in: PubMed
    16. Kutch JJ, Ichesco E, Hampson JP, Labus JS, Farmer MA, Martucci KT, Ness TJ, Deutsch G, Apkarian AV, Mackey SC, Klumpp DJ, Schaeffer AJ, Rodriguez LV, Kreder KJ, Buchwald D, Andriole GL, Lai HH, Mullins C, Kusek JW, Landis JR, Mayer EA, Clemens JQ, Clauw DJ, Harris RE. Brain signature and functional impact of centralized pain: a multidisciplinary approach to the study of chronic pelvic pain (MAPP) network study. Pain. 2017 Oct; 158(10):1979-1991. PMID: 28692006.
      View in: PubMed
    17. Sanmiguel CP, Jacobs J, Gupta A, Ju T, Stains J, Coveleskie K, Lagishetty V, Balioukova A, Chen Y, Dutson E, Mayer EA, Labus JS. Surgically Induced Changes in Gut Microbiome and Hedonic Eating as Related to Weight Loss: Preliminary Findings in Obese Women Undergoing Bariatric Surgery. Psychosom Med. 2017 Oct; 79(8):880-887. PMID: 28570438.
      View in: PubMed
    18. Tillisch K, Mayer EA, Gupta A, Gill Z, Brazeilles R, Le Nevé B, van Hylckama Vlieg JET, Guyonnet D, Derrien M, Labus JS. Brain Structure and Response to Emotional Stimuli as Related to Gut Microbial Profiles in Healthy Women. Psychosom Med. 2017 Oct; 79(8):905-913. PMID: 28661940.
      View in: PubMed
    19. Zucker N, Mauro C, Craske M, Wagner HR, Datta N, Hopkins H, Caldwell K, Kiridly A, Marsan S, Maslow G, Mayer E, Egger H. Acceptance-based interoceptive exposure for young children with functional abdominal pain. Behav Res Ther. 2017 Oct; 97:200-212. PMID: 28826066.
      View in: PubMed
    20. Bednarska O, Walter SA, Casado-Bedmar M, Ström M, Salvo-Romero E, Vicario M, Mayer EA, Keita ÅV. Vasoactive Intestinal Polypeptide and Mast Cells Regulate Increased Passage of Colonic Bacteria in Patients With Irritable Bowel Syndrome. Gastroenterology. 2017 10; 153(4):948-960.e3. PMID: 28711627.
      View in: PubMed
    21. Icenhour A, Witt ST, Elsenbruch S, Lowén M, Engström M, Tillisch K, Mayer EA, Walter S. Brain functional connectivity is associated with visceral sensitivity in women with Irritable Bowel Syndrome. Neuroimage Clin. 2017; 15:449-457. PMID: 28649489.
      View in: PubMed
    22. Kutch JJ, Labus JS, Harris RE, Martucci KT, Farmer MA, Fenske S, Fling C, Ichesco E, Peltier S, Petre B, Guo W, Hou X, Stephens AJ, Mullins C, Clauw DJ, Mackey SC, Apkarian AV, Landis JR, Mayer EA. Resting-state functional connectivity predicts longitudinal pain symptom change in urologic chronic pelvic pain syndrome: a MAPP network study. Pain. 2017 Jun; 158(6):1069-1082. PMID: 28328579.
      View in: PubMed
    23. Labus JS, Hollister EB, Jacobs J, Kirbach K, Oezguen N, Gupta A, Acosta J, Luna RA, Aagaard K, Versalovic J, Savidge T, Hsiao E, Tillisch K, Mayer EA. Differences in gut microbial composition correlate with regional brain volumes in irritable bowel syndrome. Microbiome. 2017 05 01; 5(1):49. PMID: 28457228.
      View in: PubMed
    24. Volkmann ER, Hoffmann-Vold AM, Chang YL, Jacobs JP, Tillisch K, Mayer EA, Clements PJ, Hov JR, Kummen M, Midtvedt Ø, Lagishetty V, Chang L, Labus JS, Molberg Ø, Braun J. Systemic sclerosis is associated with specific alterations in gastrointestinal microbiota in two independent cohorts. BMJ Open Gastroenterol. 2017; 4(1):e000134. PMID: 28761687.
      View in: PubMed
    25. Martin CR, Mayer EA. Gut-Brain Axis and Behavior. Nestle Nutr Inst Workshop Ser. 2017; 88:45-53. PMID: 28346923.
      View in: PubMed
    26. Gupta A, Mayer EA, Acosta JR, Hamadani K, Torgerson C, van Horn JD, Chang L, Naliboff B, Tillisch K, Labus JS. Early adverse life events are associated with altered brain network architecture in a sex- dependent manner. Neurobiol Stress. 2017 Dec; 7:16-26. PMID: 28239631.
      View in: PubMed
    27. Moussaoui N, Jacobs JP, Larauche M, Biraud M, Million M, Mayer E, Taché Y. Chronic Early-life Stress in Rat Pups Alters Basal Corticosterone, Intestinal Permeability, and Fecal Microbiota at Weaning: Influence of Sex. J Neurogastroenterol Motil. 2017 Jan 30; 23(1):135-143. PMID: 27829577.
      View in: PubMed
    28. Gupta A, Mayer EA, Fling C, Labus JS, Naliboff BD, Hong JY, Kilpatrick LA. Sex-based differences in brain alterations across chronic pain conditions. J Neurosci Res. 2017 01 02; 95(1-2):604-616. PMID: 27870423.
      View in: PubMed
    29. Gupta A, Love A, Kilpatrick LA, Labus JS, Bhatt R, Chang L, Tillisch K, Naliboff B, Mayer EA. Morphological brain measures of cortico-limbic inhibition related to resilience. J Neurosci Res. 2017 Sep; 95(9):1760-1775. PMID: 28029706.
      View in: PubMed
    30. Huang L, Kutch JJ, Ellingson BM, Martucci KT, Harris RE, Clauw DJ, Mackey S, Mayer EA, Schaeffer AJ, Apkarian AV, Farmer MA. Brain white matter changes associated with urological chronic pelvic pain syndrome: multisite neuroimaging from a MAPP case-control study. Pain. 2016 Dec; 157(12):2782-2791. PMID: 27842046.
      View in: PubMed
    31. Henström M, Diekmann L, Bonfiglio F, Hadizadeh F, Kuech EM, von Köckritz-Blickwede M, Thingholm LB, Zheng T, Assadi G, Dierks C, Heine M, Philipp U, Distl O, Money ME, Belheouane M, Heinsen FA, Rafter J, Nardone G, Cuomo R, Usai-Satta P, Galeazzi F, Neri M, Walter S, Simrén M, Karling P, Ohlsson B, Schmidt PT, Lindberg G, Dlugosz A, Agreus L, Andreasson A, Mayer E, Baines JF, Engstrand L, Portincasa P, Bellini M, Stanghellini V, Barbara G, Chang L, Camilleri M, Franke A, Naim HY, D'Amato M. Functional variants in the sucrase-isomaltase gene associate with increased risk of irritable bowel syndrome. Gut. 2018 02; 67(2):263-270. PMID: 27872184.
      View in: PubMed
    32. Tilg H, Cani PD, Mayer EA. Gut microbiome and liver diseases. Gut. 2016 12; 65(12):2035-2044. PMID: 27802157.
      View in: PubMed
    33. Orand A, Naliboff B, Gadd M, Shih W, Ju T, Presson AP, Mayer EA, Chang L. Corticotropin-releasing hormone receptor 1 (CRH-R1) polymorphisms are associated with irritable bowel syndrome and acoustic startle response. Psychoneuroendocrinology. 2016 Nov; 73:133-141. PMID: 27497153.
      View in: PubMed
    34. Moussaoui N, Larauche M, Biraud M, Molet J, Million M, Mayer E, Taché Y. Limited Nesting Stress Alters Maternal Behavior and In Vivo Intestinal Permeability in Male Wistar Pup Rats. PLoS One. 2016; 11(5):e0155037. PMID: 27149676; PMCID: PMC4858303.
    35. Videlock EJ, Shih W, Adeyemo M, Mahurkar-Joshi S, Presson AP, Polytarchou C, Alberto M, Iliopoulos D, Mayer EA, Chang L. The effect of sex and irritable bowel syndrome on HPA axis response and peripheral glucocorticoid receptor expression. Psychoneuroendocrinology. 2016 07; 69:67-76. PMID: 27038676.
      View in: PubMed
    36. Enck P, Aziz Q, Barbara G, Farmer AD, Fukudo S, Mayer EA, Niesler B, Quigley EM, Rajilic-Stojanovic M, Schemann M, Schwille-Kiuntke J, Simren M, Zipfel S, Spiller RC. Irritable bowel syndrome. Nat Rev Dis Primers. 2016 03 24; 2:16014. PMID: 27159638.
      View in: PubMed
    37. Latorre R, Huynh J, Mazzoni M, Gupta A, Bonora E, Clavenzani P, Chang L, Mayer EA, De Giorgio R, Sternini C. Expression of the Bitter Taste Receptor, T2R38, in Enteroendocrine Cells of the Colonic Mucosa of Overweight/Obese vs. Lean Subjects. PLoS One. 2016; 11(2):e0147468. PMID: 26866366; PMCID: PMC4750998.
    38. Alger JR, Ellingson BM, Ashe-McNalley C, Woodworth DC, Labus JS, Farmer M, Huang L, Apkarian AV, Johnson KA, Mackey SC, Ness TJ, Deutsch G, Harris RE, Clauw DJ, Glover GH, Parrish TB, Hollander Jd, Kusek JW, Mullins C, Mayer EA. Multisite, multimodal neuroimaging of chronic urological pelvic pain: Methodology of the MAPP Research Network. Neuroimage Clin. 2016; 12:65-77. PMID: 27408791; PMCID: PMC4925887.
    39. Jarcho JM, Feier NA, Labus JS, Naliboff B, Smith SR, Hong JY, Colloca L, Tillisch K, Mandelkern MA, Mayer EA, London ED. Placebo analgesia: Self-report measures and preliminary evidence of cortical dopamine release associated with placebo response. Neuroimage Clin. 2016; 10:107-14. PMID: 26759785; PMCID: PMC4683423.
    40. Woodworth D, Mayer E, Leu K, Ashe-McNalley C, Naliboff BD, Labus JS, Tillisch K, Kutch JJ, Farmer MA, Apkarian AV, Johnson KA, Mackey SC, Ness TJ, Landis JR, Deutsch G, Harris RE, Clauw DJ, Mullins C, Ellingson BM. Unique Microstructural Changes in the Brain Associated with Urological Chronic Pelvic Pain Syndrome (UCPPS) Revealed by Diffusion Tensor MRI, Super-Resolution Track Density Imaging, and Statistical Parameter Mapping: A MAPP Network Neuroimaging Study. PLoS One. 2015; 10(10):e0140250. PMID: 26460744; PMCID: PMC4604194.
    41. Kilpatrick LA, Istrin JJ, Gupta A, Naliboff BD, Tillisch K, Labus JS, Mayer EA. Sex commonalities and differences in the relationship between resilient personality and the intrinsic connectivity of the salience and default mode networks. Biol Psychol. 2015 Dec; 112:107-15. PMID: 26440126; PMCID: PMC5012423 [Available on 12/01/16].
    42. Martucci KT, Shirer WR, Bagarinao E, Johnson KA, Farmer MA, Labus JS, Apkarian AV, Deutsch G, Harris RE, Mayer EA, Clauw DJ, Greicius MD, Mackey SC. The posterior medial cortex in urologic chronic pelvic pain syndrome: detachment from default mode network-a resting-state study from the MAPP Research Network. Pain. 2015 Sep; 156(9):1755-64. PMID: 26010458; PMCID: PMC4545714.
    43. Mayer EA, Labus JS, Tillisch K, Cole SW, Baldi P. Towards a systems view of IBS. Nat Rev Gastroenterol Hepatol. 2015 Oct; 12(10):592-605. PMID: 26303675; PMCID: PMC5001844.
    44. Orand A, Gupta A, Shih W, Presson AP, Hammer C, Niesler B, Heendeniya N, Mayer EA, Chang L. Catecholaminergic Gene Polymorphisms Are Associated with GI Symptoms and Morphological Brain Changes in Irritable Bowel Syndrome. PLoS One. 2015; 10(8):e0135910. PMID: 26288143; PMCID: PMC4546052.
    45. Labus JS, Van Horn JD, Gupta A, Alaverdyan M, Torgerson C, Ashe-McNalley C, Irimia A, Hong JY, Naliboff B, Tillisch K, Mayer EA. Multivariate morphological brain signatures predict patients with chronic abdominal pain from healthy control subjects. Pain. 2015 Aug; 156(8):1545-54. PMID: 25906347; PMCID: PMC4504800.
    46. Bradesi S, Karagiannides I, Bakirtzi K, Joshi SM, Koukos G, Iliopoulos D, Pothoulakis C, Mayer EA. Identification of Spinal Cord MicroRNA and Gene Signatures in a Model of Chronic Stress-Induced Visceral Hyperalgesia in Rat. PLoS One. 2015; 10(7):e0130938. PMID: 26222740; PMCID: PMC4519289.
    47. Kutch JJ, Yani MS, Asavasopon S, Kirages DJ, Rana M, Cosand L, Labus JS, Kilpatrick LA, Ashe-McNalley C, Farmer MA, Johnson KA, Ness TJ, Deutsch G, Harris RE, Apkarian AV, Clauw DJ, Mackey SC, Mullins C, Mayer EA. Altered resting state neuromotor connectivity in men with chronic prostatitis/chronic pelvic pain syndrome: A MAPP: Research Network Neuroimaging Study. Neuroimage Clin. 2015; 8:493-502. PMID: 26106574; PMCID: PMC4474411.
    48. Sanmiguel C, Gupta A, Mayer EA. Gut Microbiome and Obesity: A Plausible Explanation for Obesity. Curr Obes Rep. 2015 Jun; 4(2):250-61. PMID: 26029487; PMCID: PMC4443745.
    49. Gupta A, Rapkin AJ, Gill Z, Kilpatrick L, Fling C, Stains J, Masghati S, Tillisch K, Mayer EA, Labus JS. Disease-related differences in resting-state networks: a comparison between localized provoked vulvodynia, irritable bowel syndrome, and healthy control subjects. Pain. 2015 May; 156(5):809-19. PMID: 25735001; PMCID: PMC4402252.
    50. Kilpatrick LA, Mayer EA, Labus JS, Gupta A, Hamaguchi T, Mizuno T, Komuro H, Kano M, Kanazawa M, Aoki M, Fukudo S. Serotonin Transporter Gene Polymorphism Modulates Activity and Connectivity within an Emotional Arousal Network of Healthy Men during an Aversive Visceral Stimulus. PLoS One. 2015; 10(4):e0123183. PMID: 25893242; PMCID: PMC4404144.
    51. Labus JS, Naliboff B, Kilpatrick L, Liu C, Ashe-McNalley C, dos Santos IR, Alaverdyan M, Woodworth D, Gupta A, Ellingson BM, Tillisch K, Mayer EA. Pain and Interoception Imaging Network (PAIN): A multimodal, multisite, brain-imaging repository for chronic somatic and visceral pain disorders. Neuroimage. 2016 Jan 01; 124(Pt B):1232-7. PMID: 25902408; PMCID: PMC4627849 [Available on 01/01/17].
    52. Mayer EA, Gupta A, Kilpatrick LA, Hong JY. Imaging brain mechanisms in chronic visceral pain. Pain. 2015 Apr; 156 Suppl 1:S50-63. PMID: 25789437; PMCID: PMC4428597.
    53. Farmer MA, Huang L, Martucci K, Yang CC, Maravilla KR, Harris RE, Clauw DJ, Mackey S, Ellingson BM, Mayer EA, Schaeffer AJ, Apkarian AV. Brain White Matter Abnormalities in Female Interstitial Cystitis/Bladder Pain Syndrome: A MAPP Network Neuroimaging Study. J Urol. 2015 Jul; 194(1):118-26. PMID: 25711200; PMCID: PMC4475466.
    54. Mayer EA, Tillisch K, Gupta A. Gut/brain axis and the microbiota. J Clin Invest. 2015 Mar 02; 125(3):926-38. PMID: 25689247; PMCID: PMC4362231.
    55. Gupta A, Labus J, Kilpatrick LA, Bonyadi M, Ashe-McNalley C, Heendeniya N, Bradesi S, Chang L, Mayer EA. Interactions of early adversity with stress-related gene polymorphisms impact regional brain structure in females. Brain Struct Funct. 2016 Apr; 221(3):1667-79. PMID: 25630611; PMCID: PMC4573367 [Available on 04/01/17].
    56. Langguth B, Sturm K, Wetter TC, Lange M, Gabriels L, Mayer EA, Schlaier J. Deep Brain Stimulation for Obsessive Compulsive Disorder Reduces Symptoms of Irritable Bowel Syndrome in a Single Patient. Clin Gastroenterol Hepatol. 2015 Jul; 13(7):1371-1374.e3. PMID: 25638586; PMCID: PMC4986991.
    57. Gupta A, Mayer EA, Sanmiguel CP, Van Horn JD, Woodworth D, Ellingson BM, Fling C, Love A, Tillisch K, Labus JS. Patterns of brain structural connectivity differentiate normal weight from overweight subjects. Neuroimage Clin. 2015; 7:506-17. PMID: 25737959; PMCID: PMC4338207.
    58. Guo Y, Wang Z, Mayer EA, Holschneider DP. Neonatal stress from limited bedding elicits visceral hyperalgesia in adult rats. Neuroreport. 2015 Jan 07; 26(1):13-6. PMID: 25426824; PMCID: PMC4246414.
    59. Lee UJ, Ackerman AL, Wu A, Zhang R, Leung J, Bradesi S, Mayer EA, Rodríguez LV. Chronic psychological stress in high-anxiety rats induces sustained bladder hyperalgesia. Physiol Behav. 2015 Feb; 139:541-8. PMID: 25449389.
      View in: PubMed
    60. Blumstein DT, Levy K, Mayer E, Harte J. Gastrointestinal dysbiosis. Evol Med Public Health. 2014; 2014(1):163. PMID: 25416734.
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    61. Mayer EA, Knight R, Mazmanian SK, Cryan JF, Tillisch K. Gut microbes and the brain: paradigm shift in neuroscience. J Neurosci. 2014 Nov 12; 34(46):15490-6. PMID: 25392516; PMCID: PMC4228144.
    62. Hong JY, Kilpatrick LA, Labus JS, Gupta A, Katibian D, Ashe-McNalley C, Stains J, Heendeniya N, Smith SR, Tillisch K, Naliboff B, Mayer EA. Sex and disease-related alterations of anterior insula functional connectivity in chronic abdominal pain. J Neurosci. 2014 Oct 22; 34(43):14252-9. PMID: 25339739; PMCID: PMC4205551.
    63. Bagarinao E, Johnson KA, Martucci KT, Ichesco E, Farmer MA, Labus J, Ness TJ, Harris R, Deutsch G, Apkarian AV, Mayer EA, Clauw DJ, Mackey S. Preliminary structural MRI based brain classification of chronic pelvic pain: A MAPP network study. Pain. 2014 Dec; 155(12):2502-9. PMID: 25242566.
      View in: PubMed
    64. Mayer EA, Padua D, Tillisch K. Altered brain-gut axis in autism: comorbidity or causative mechanisms? Bioessays. 2014 Oct; 36(10):933-9. PMID: 25145752.
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    65. Kairys AE, Schmidt-Wilcke T, Puiu T, Ichesco E, Labus JS, Martucci K, Farmer MA, Ness TJ, Deutsch G, Mayer EA, Mackey S, Apkarian AV, Maravilla K, Clauw DJ, Harris RE. Increased brain gray matter in the primary somatosensory cortex is associated with increased pain and mood disturbance in patients with interstitial cystitis/painful bladder syndrome. J Urol. 2015 Jan; 193(1):131-7. PMID: 25132239.
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    66. Landis JR, Williams DA, Lucia MS, Clauw DJ, Naliboff BD, Robinson NA, van Bokhoven A, Sutcliffe S, Schaeffer AJ, Rodriguez LV, Mayer EA, Lai HH, Krieger JN, Kreder KJ, Afari N, Andriole GL, Bradley CS, Griffith JW, Klumpp DJ, Hong BA, Lutgendorf SK, Buchwald D, Yang CC, Mackey S, Pontari MA, Hanno P, Kusek JW, Mullins C, Clemens JQ. The MAPP research network: design, patient characterization and operations. BMC Urol. 2014 Aug 01; 14:58. PMID: 25085119; PMCID: PMC4126395.
    67. Clemens JQ, Mullins C, Kusek JW, Kirkali Z, Mayer EA, Rodríguez LV, Klumpp DJ, Schaeffer AJ, Kreder KJ, Buchwald D, Andriole GL, Lucia MS, Landis JR, Clauw DJ. The MAPP research network: a novel study of urologic chronic pelvic pain syndromes. BMC Urol. 2014 Aug 01; 14:57. PMID: 25085007; PMCID: PMC4134515.
    68. Gupta A, Kilpatrick L, Labus J, Tillisch K, Braun A, Hong JY, Ashe-McNalley C, Naliboff B, Mayer EA. Early adverse life events and resting state neural networks in patients with chronic abdominal pain: evidence for sex differences. Psychosom Med. 2014 Jul-Aug; 76(6):404-12. PMID: 25003944; PMCID: PMC4113723.
    69. Stabell N, Stubhaug A, Flægstad T, Mayer E, Naliboff BD, Nielsen CS. Widespread hyperalgesia in adolescents with symptoms of irritable bowel syndrome: results from a large population-based study. J Pain. 2014 Sep; 15(9):898-906. PMID: 24905280.
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    70. Dinov ID, Petrosyan P, Liu Z, Eggert P, Zamanyan A, Torri F, Macciardi F, Hobel S, Moon SW, Sung YH, Jiang Z, Labus J, Kurth F, Ashe-McNalley C, Mayer E, Vespa PM, Van Horn JD, Toga AW. The perfect neuroimaging-genetics-computation storm: collision of petabytes of data, millions of hardware devices and thousands of software tools. Brain Imaging Behav. 2014 Jun; 8(2):311-22. PMID: 23975276; PMCID: PMC3933453.
    71. Kilpatrick LA, Kutch JJ, Tillisch K, Naliboff BD, Labus JS, Jiang Z, Farmer MA, Apkarian AV, Mackey S, Martucci KT, Clauw DJ, Harris RE, Deutsch G, Ness TJ, Yang CC, Maravilla K, Mullins C, Mayer EA. Alterations in resting state oscillations and connectivity in sensory and motor networks in women with interstitial cystitis/painful bladder syndrome. J Urol. 2014 Sep; 192(3):947-55. PMID: 24681331.
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    72. Mayer EA, Savidge T, Shulman RJ. Brain-gut microbiome interactions and functional bowel disorders. Gastroenterology. 2014 May; 146(6):1500-12. PMID: 24583088.
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    74. Hong JY, Labus JS, Jiang Z, Ashe-Mcnalley C, Dinov I, Gupta A, Shi Y, Stains J, Heendeniya N, Smith SR, Tillisch K, Mayer EA. Regional neuroplastic brain changes in patients with chronic inflammatory and non-inflammatory visceral pain. PLoS One. 2014; 9(1):e84564. PMID: 24416245; PMCID: PMC3885578.
    75. Chang MC, Shapiro D, Joshi A, Shahabi L, Tan S, Smith S, Hui KK, Tillisch K, Mayer EA, Naliboff BD. Stress reactivity in traditional Chinese medicine-based subgroups of patients with irritable bowel syndrome. J Altern Complement Med. 2014 Apr; 20(4):276-83. PMID: 24256027; PMCID: PMC3994910.
    76. Labus JS, Dinov ID, Jiang Z, Ashe-McNalley C, Zamanyan A, Shi Y, Hong JY, Gupta A, Tillisch K, Ebrat B, Hobel S, Gutman BA, Joshi S, Thompson PM, Toga AW, Mayer EA. Irritable bowel syndrome in female patients is associated with alterations in structural brain networks. Pain. 2014 Jan; 155(1):137-49. PMID: 24076048; PMCID: PMC4100785.
    77. Grasberger H, Chang L, Shih W, Presson AP, Sayuk GS, Newberry RD, Karagiannides I, Pothoulakis C, Mayer E, Merchant JL. Identification of a functional TPH1 polymorphism associated with irritable bowel syndrome bowel habit subtypes. Am J Gastroenterol. 2013 Nov; 108(11):1766-74. PMID: 24060757; PMCID: PMC4067697.
    78. Jiang Z, Dinov ID, Labus J, Shi Y, Zamanyan A, Gupta A, Ashe-McNalley C, Hong JY, Tillisch K, Toga AW, Mayer EA. Sex-related differences of cortical thickness in patients with chronic abdominal pain. PLoS One. 2013; 8(9):e73932. PMID: 24040118; PMCID: PMC3764047.
    79. Labus JS, Hubbard CS, Bueller J, Ebrat B, Tillisch K, Chen M, Stains J, Dukes GE, Kelleher DL, Naliboff BD, Fanselow M, Mayer EA. Impaired emotional learning and involvement of the corticotropin-releasing factor signaling system in patients with irritable bowel syndrome. Gastroenterology. 2013 Dec; 145(6):1253-61.e1-3. PMID: 23954313; PMCID: PMC4069031.
    80. Hong JY, Kilpatrick LA, Labus J, Gupta A, Jiang Z, Ashe-McNalley C, Stains J, Heendeniya N, Ebrat B, Smith S, Tillisch K, Naliboff B, Mayer EA. Patients with chronic visceral pain show sex-related alterations in intrinsic oscillations of the resting brain. J Neurosci. 2013 Jul 17; 33(29):11994-2002. PMID: 23864686; PMCID: PMC3713732.
    81. Labus JS, Gupta A, Coveleskie K, Tillisch K, Kilpatrick L, Jarcho J, Feier N, Bueller J, Stains J, Smith S, Suyenobu B, Naliboff B, Mayer EA. Sex differences in emotion-related cognitive processes in irritable bowel syndrome and healthy control subjects. Pain. 2013 Oct; 154(10):2088-99. PMID: 23791896; PMCID: PMC4049231.
    82. Ellingson BM, Mayer E, Harris RJ, Ashe-McNally C, Naliboff BD, Labus JS, Tillisch K. Diffusion tensor imaging detects microstructural reorganization in the brain associated with chronic irritable bowel syndrome. Pain. 2013 Sep; 154(9):1528-41. PMID: 23721972; PMCID: PMC3758125.
    83. Lackner JM, Ma CX, Keefer L, Brenner DM, Gudleski GD, Satchidanand N, Firth R, Sitrin MD, Katz L, Krasner SS, Ballou SK, Naliboff BD, Mayer EA. Type, rather than number, of mental and physical comorbidities increases the severity of symptoms in patients with irritable bowel syndrome. Clin Gastroenterol Hepatol. 2013 Sep; 11(9):1147-57. PMID: 23524278; PMCID: PMC3779619.
    84. Mayer EA, Tillisch K, Ellingson BM. Dyspepsia: Structural changes in functional gastrointestinal disorders. Nat Rev Gastroenterol Hepatol. 2013 Apr; 10(4):200-2. PMID: 23507797.
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    85. Wang Z, Ocampo MA, Pang RD, Bota M, Bradesi S, Mayer EA, Holschneider DP. Alterations in prefrontal-limbic functional activation and connectivity in chronic stress-induced visceral hyperalgesia. PLoS One. 2013; 8(3):e59138. PMID: 23527114; PMCID: PMC3602545.
    86. Sanders ME, Guarner F, Guerrant R, Holt PR, Quigley EM, Sartor RB, Sherman PM, Mayer EA. An update on the use and investigation of probiotics in health and disease. Gut. 2013 May; 62(5):787-96. PMID: 23474420; PMCID: PMC4351195.
    87. Tillisch K, Labus J, Kilpatrick L, Jiang Z, Stains J, Ebrat B, Guyonnet D, Legrain-Raspaud S, Trotin B, Naliboff B, Mayer EA. Consumption of fermented milk product with probiotic modulates brain activity. Gastroenterology. 2013 Jun; 144(7):1394-401, 1401.e1-4. PMID: 23474283; PMCID: PMC3839572.
    88. Jarcho JM, Feier NA, Bert A, Labus JA, Lee M, Stains J, Ebrat B, Groman SM, Tillisch K, Brody AL, London ED, Mandelkern MA, Mayer EA. Diminished neurokinin-1 receptor availability in patients with two forms of chronic visceral pain. Pain. 2013 Jul; 154(7):987-96. PMID: 23582152; PMCID: PMC4294187.
    89. Mayer EA. Gut sensations - not so gut specific after all? Pain. 2013 May; 154(5):627-8. PMID: 23523117.
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    90. Guyonnet D, Naliboff B, Rondeau P, Mayer E, Chassany O. Gastrointestinal well-being in subjects reporting mild gastrointestinal discomfort: characteristics and properties of a global assessment measure. Br J Nutr. 2013 Oct; 110(7):1263-71. PMID: 23432848.
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    91. Rubenstein PA, Mayer EA. Familial visceral myopathies: from symptom-based syndromes to actin-related diseases. Gastroenterology. 2012 Dec; 143(6):1420-3. PMID: 23085350.
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    92. Golovatscka V, Ennes H, Mayer EA, Bradesi S. Chronic stress-induced changes in pro-inflammatory cytokines and spinal glia markers in the rat: a time course study. Neuroimmunomodulation. 2012; 19(6):367-76. PMID: 23051934; PMCID: PMC3535433.
    93. Berman S, Suyenobu B, Naliboff BD, Bueller J, Stains J, Wong H, Mandelkern M, Fitzgerald L, Ohning G, Gupta A, Labus JS, Tillisch K, Mayer EA. Evidence for alterations in central noradrenergic signaling in irritable bowel syndrome. Neuroimage. 2012 Dec; 63(4):1854-63. PMID: 22917679; PMCID: PMC4130741.
    94. Wolitzky-Taylor K, Craske MG, Labus JS, Mayer EA, Naliboff BD. Visceral sensitivity as a mediator of outcome in the treatment of irritable bowel syndrome. Behav Res Ther. 2012 Oct; 50(10):647-50. PMID: 22877888; PMCID: PMC4226616.
    95. Wolf-Johnston AS, Hanna-Mitchell AT, Buffington CA, Shinde S, Roppolo JR, Mayer E, Birder LA. Alterations in the non-neuronal acetylcholine synthesis and release machinery in esophageal epithelium. Life Sci. 2012 Nov 27; 91(21-22):1065-9. PMID: 22569297; PMCID: PMC3435437.
    96. Kurth F, Mayer EA, Toga AW, Thompson PM, Luders E. The right inhibition? Callosal correlates of hand performance in healthy children and adolescents callosal correlates of hand performance. Hum Brain Mapp. 2013 Sep; 34(9):2259-65. PMID: 22438280.
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    97. Guo CC, Kurth F, Zhou J, Mayer EA, Eickhoff SB, Kramer JH, Seeley WW. One-year test-retest reliability of intrinsic connectivity network fMRI in older adults. Neuroimage. 2012 Jul 16; 61(4):1471-83. PMID: 22446491; PMCID: PMC4226138.
    98. Jarcho JM, Mayer EA, Jiang ZK, Feier NA, London ED. Pain, affective symptoms, and cognitive deficits in patients with cerebral dopamine dysfunction. Pain. 2012 Apr; 153(4):744-54. PMID: 22386471; PMCID: PMC3816524.
    99. Luders E, Kurth F, Mayer EA, Toga AW, Narr KL, Gaser C. The unique brain anatomy of meditation practitioners: alterations in cortical gyrification. Front Hum Neurosci. 2012; 6:34. PMID: 22393318; PMCID: PMC3289949.
    100. Mayer EA, Brunnhuber S. Gastrointestinal disorders. Handb Clin Neurol. 2012; 106:607-31. PMID: 22608647.
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    101. Bradford K, Shih W, Videlock EJ, Presson AP, Naliboff BD, Mayer EA, Chang L. Association between early adverse life events and irritable bowel syndrome. Clin Gastroenterol Hepatol. 2012 Apr; 10(4):385-90.e1-3. PMID: 22178460; PMCID: PMC3311761.
    102. Chang L, Adeyemo M, Karagiannides I, Karagiannidis I, Videlock EJ, Bowe C, Shih W, Presson AP, Yuan PQ, Cortina G, Gong H, Singh S, Licudine A, Mayer M, Tache Y, Pothoulakis C, Mayer EA. Serum and colonic mucosal immune markers in irritable bowel syndrome. Am J Gastroenterol. 2012 Feb; 107(2):262-72. PMID: 22158028; PMCID: PMC3297737.
    103. Larsson MB, Tillisch K, Craig AD, Engström M, Labus J, Naliboff B, Lundberg P, Ström M, Mayer EA, Walter SA. Brain responses to visceral stimuli reflect visceral sensitivity thresholds in patients with irritable bowel syndrome. Gastroenterology. 2012 Mar; 142(3):463-472.e3. PMID: 22108191; PMCID: PMC3288538.
    104. Naliboff BD, Kim SE, Bolus R, Bernstein CN, Mayer EA, Chang L. Gastrointestinal and psychological mediators of health-related quality of life in IBS and IBD: a structural equation modeling analysis. Am J Gastroenterol. 2012 Mar; 107(3):451-9. PMID: 22085819; PMCID: PMC3855477.
    105. Wang Z, Bradesi S, Charles JR, Pang RD, Maarek JM, Mayer EA, Holschneider DP. Functional brain activation during retrieval of visceral pain-conditioned passive avoidance in the rat. Pain. 2011 Dec; 152(12):2746-56. PMID: 21944154; PMCID: PMC3215895.
    106. Hubbard CS, Labus JS, Bueller J, Stains J, Suyenobu B, Dukes GE, Kelleher DL, Tillisch K, Naliboff BD, Mayer EA. Corticotropin-releasing factor receptor 1 antagonist alters regional activation and effective connectivity in an emotional-arousal circuit during expectation of abdominal pain. J Neurosci. 2011 Aug 31; 31(35):12491-500. PMID: 21880911; PMCID: PMC3399687.
    107. Smith AL, Leung J, Kun S, Zhang R, Karagiannides I, Raz S, Lee U, Glovatscka V, Pothoulakis C, Bradesi S, Mayer EA, Rodríguez LV. The effects of acute and chronic psychological stress on bladder function in a rodent model. Urology. 2011 Oct; 78(4):967.e1-7. PMID: 21868072; PMCID: PMC3190050.
    108. Mayer EA. Gut feelings: the emerging biology of gut-brain communication. Nat Rev Neurosci. 2011 Jul 13; 12(8):453-66. PMID: 21750565; PMCID: PMC3845678.
    109. Bradesi S, Golovatscka V, Ennes HS, McRoberts JA, Karagiannides I, Karagiannidis I, Bakirtzi K, Pothoulakis C, Mayer EA. Role of astrocytes and altered regulation of spinal glutamatergic neurotransmission in stress-induced visceral hyperalgesia in rats. Am J Physiol Gastrointest Liver Physiol. 2011 Sep; 301(3):G580-9. PMID: 21719739; PMCID: PMC3174538.
    110. Birder LA, Hanna-Mitchell AT, Mayer E, Buffington CA. Cystitis, co-morbid disorders and associated epithelial dysfunction. Neurourol Urodyn. 2011 Jun; 30(5):668-72. PMID: 21661011; PMCID: PMC3113628.
    111. Craske MG, Wolitzky-Taylor KB, Labus J, Wu S, Frese M, Mayer EA, Naliboff BD. A cognitive-behavioral treatment for irritable bowel syndrome using interoceptive exposure to visceral sensations. Behav Res Ther. 2011 Jun; 49(6-7):413-21. PMID: 21565328; PMCID: PMC3100429.
    112. Sadler TR, Nguyen PT, Yang J, Givrad TK, Mayer EA, Maarek JM, Hinton DR, Holschneider DP. Antenatal maternal stress alters functional brain responses in adult offspring during conditioned fear. Brain Res. 2011 Apr 18; 1385:163-74. PMID: 21300034; PMCID: PMC3065538.
    113. Hubbard CS, Ornitz E, Gaspar JX, Smith S, Amin J, Labus JS, Kilpatrick LA, Rhudy JL, Mayer EA, Naliboff BD. Modulation of nociceptive and acoustic startle responses to an unpredictable threat in men and women. Pain. 2011 Jul; 152(7):1632-40. PMID: 21477924; PMCID: PMC3114174.
    114. Mayer EA. The search for biomarkers and endophenotypes in functional gastrointestinal disorders. Gastroenterology. 2011 May; 140(5):1377-9. PMID: 21439260; PMCID: PMC3839575.
    115. Kilpatrick LA, Labus JS, Coveleskie K, Hammer C, Rappold G, Tillisch K, Bueller JA, Suyenobu B, Jarcho JM, McRoberts JA, Niesler B, Mayer EA. The HTR3A polymorphism c. -42C>T is associated with amygdala responsiveness in patients with irritable bowel syndrome. Gastroenterology. 2011 Jun; 140(7):1943-51. PMID: 21420406; PMCID: PMC3757951.
    116. Kilpatrick LA, Suyenobu BY, Smith SR, Bueller JA, Goodman T, Creswell JD, Tillisch K, Mayer EA, Naliboff BD. Impact of Mindfulness-Based Stress Reduction training on intrinsic brain connectivity. Neuroimage. 2011 May 01; 56(1):290-8. PMID: 21334442; PMCID: PMC3072791.
    117. Holschneider DP, Bradesi S, Mayer EA. The role of experimental models in developing new treatments for irritable bowel syndrome. Expert Rev Gastroenterol Hepatol. 2011 Feb; 5(1):43-57. PMID: 21309671; PMCID: PMC3124306.
    118. Mayer EA, Tillisch K. The brain-gut axis in abdominal pain syndromes. Annu Rev Med. 2011; 62:381-96. PMID: 21090962; PMCID: PMC3817711.
    119. Kilpatrick LA, Ornitz E, Ibrahimovic H, Hubbard CS, Rodríguez LV, Mayer EA, Naliboff BD. Gating of sensory information differs in patients with interstitial cystitis/painful bladder syndrome. J Urol. 2010 Sep; 184(3):958-63. PMID: 20643444; PMCID: PMC3113603.
    120. Tillisch K, Mayer EA, Labus JS. Quantitative meta-analysis identifies brain regions activated during rectal distension in irritable bowel syndrome. Gastroenterology. 2011 Jan; 140(1):91-100. PMID: 20696168; PMCID: PMC3253553.
    121. Anderson A, Labus JS, Vianna EP, Mayer EA, Cohen MS. Common component classification: what can we learn from machine learning? Neuroimage. 2011 May 15; 56(2):517-24. PMID: 20599621; PMCID: PMC2966513.
    122. Seminowicz DA, Labus JS, Bueller JA, Tillisch K, Naliboff BD, Bushnell MC, Mayer EA. Regional gray matter density changes in brains of patients with irritable bowel syndrome. Gastroenterology. 2010 Jul; 139(1):48-57.e2. PMID: 20347816; PMCID: PMC2902717.
    123. Bradesi S, Mayer EA. Experimental models of stress and pain: do they help to develop new therapies? Dig Dis. 2009; 27 Suppl 1:55-67. PMID: 20203498.
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    124. Saito YA, Mitra N, Mayer EA. Genetic approaches to functional gastrointestinal disorders. Gastroenterology. 2010 Apr; 138(4):1276-85. PMID: 20176021; PMCID: PMC3829382.
    125. Videlock EJ, Adeyemo M, Licudine A, Hirano M, Ohning G, Mayer M, Mayer EA, Chang L. Childhood trauma is associated with hypothalamic-pituitary-adrenal axis responsiveness in irritable bowel syndrome. Gastroenterology. 2009 Dec; 137(6):1954-62. PMID: 19737564; PMCID: PMC2789911.
    126. Benninga MA, Mayer EA. The power of placebo in pediatric functional gastrointestinal disease. Gastroenterology. 2009 Oct; 137(4):1207-10. PMID: 19717127.
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    127. Camilleri M, Mayer EA. Developing irritable bowel syndrome guidelines through meta-analyses: does the emperor really have new clothes? Gastroenterology. 2009 Sep; 137(3):766-9. PMID: 19643191.
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    128. Wang Z, Guo Y, Bradesi S, Labus JS, Maarek JI, Lee K, Winchester WJ, Mayer EA, Holschneider DP. Sex differences in functional brain activation during noxious visceral stimulation in rats. Pain. 2009 Sep; 145(1-2):120-128. PMID: 19560270; PMCID: PMC2756542.
    129. Labus JS, Naliboff BD, Berman SM, Suyenobu B, Vianna EP, Tillisch K, Mayer EA. Brain networks underlying perceptual habituation to repeated aversive visceral stimuli in patients with irritable bowel syndrome. Neuroimage. 2009 Sep; 47(3):952-60. PMID: 19501173; PMCID: PMC3399695.
    130. Spiegel B, Harris L, Lucak S, Mayer E, Naliboff B, Bolus R, Esrailian E, Chey WD, Lembo A, Karsan H, Tillisch K, Dulai G, Talley J, Chang L. Developing valid and reliable health utilities in irritable bowel syndrome: results from the IBS PROOF Cohort. Am J Gastroenterol. 2009 Aug; 104(8):1984-91. PMID: 19491835; PMCID: PMC3839573.
    131. Rhee SH, Pothoulakis C, Mayer EA. Principles and clinical implications of the brain-gut-enteric microbiota axis. Nat Rev Gastroenterol Hepatol. 2009 May; 6(5):306-14. PMID: 19404271; PMCID: PMC3817714.
    132. Twiss C, Kilpatrick L, Craske M, Buffington CA, Ornitz E, Rodríguez LV, Mayer EA, Naliboff BD. Increased startle responses in interstitial cystitis: evidence for central hyperresponsiveness to visceral related threat. J Urol. 2009 May; 181(5):2127-33. PMID: 19286199; PMCID: PMC3094570.
    133. Hultgren S, Goldstein JM, Delancey JO, Bandstra ES, Brady KT, Brown JS, Deng HW, Dunaif A, Ehrmann DA, Mayer EA, Sinha R, Tobet S, Levine JE. The vital role of ORWH. Science. 2009 Feb 20; 323(5917):1009-10. PMID: 19229019.
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    134. Bradesi S, Svensson CI, Steinauer J, Pothoulakis C, Yaksh TL, Mayer EA. Role of spinal microglia in visceral hyperalgesia and NK1R up-regulation in a rat model of chronic stress. Gastroenterology. 2009 Apr; 136(4):1339-48, e1-2. PMID: 19249394; PMCID: PMC2812027.
    135. Bradesi S, Martinez V, Lao L, Larsson H, Mayer EA. Involvement of vasopressin 3 receptors in chronic psychological stress-induced visceral hyperalgesia in rats. Am J Physiol Gastrointest Liver Physiol. 2009 Feb; 296(2):G302-9. PMID: 19033533.
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    136. Tillisch K, Wang Z, Kilpatrick L, Holschneider DP, Mayer EA. Studying the brain-gut axis with pharmacological imaging. Ann N Y Acad Sci. 2008 Nov; 1144:256-64. PMID: 19076383; PMCID: PMC3817712.
    137. Naliboff BD, Waters AM, Labus JS, Kilpatrick L, Craske MG, Chang L, Negoro H, Ibrahimovic H, Mayer EA, Ornitz E. Increased acoustic startle responses in IBS patients during abdominal and nonabdominal threat. Psychosom Med. 2008 Oct; 70(8):920-7. PMID: 18842745; PMCID: PMC4104120.
    138. Bradesi S, Herman J, Mayer EA. Visceral analgesics: drugs with a great potential in functional disorders? Curr Opin Pharmacol. 2008 Dec; 8(6):697-703. PMID: 18786654; PMCID: PMC2651816.
    139. Spiegel B, Strickland A, Naliboff BD, Mayer EA, Chang L. Predictors of patient-assessed illness severity in irritable bowel syndrome. Am J Gastroenterol. 2008 Oct; 103(10):2536-43. PMID: 18637089; PMCID: PMC2949074.
    140. Wang Z, Bradesi S, Maarek JM, Lee K, Winchester WJ, Mayer EA, Holschneider DP. Regional brain activation in conscious, nonrestrained rats in response to noxious visceral stimulation. Pain. 2008 Aug 15; 138(1):233-43. PMID: 18538929; PMCID: PMC3816530.
    141. Mayer EA. The challenge of studying the biology of complex, symptom-based GI disorders. Gastroenterology. 2008 Jun; 134(7):1826-7. PMID: 18477481.
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    142. Mayer EA. Clinical practice. Irritable bowel syndrome. N Engl J Med. 2008 Apr 17; 358(16):1692-9. PMID: 18420501; PMCID: PMC3816529.
    143. Larauche M, Bradesi S, Million M, McLean P, Taché Y, Mayer EA, McRoberts JA. Corticotropin-releasing factor type 1 receptors mediate the visceral hyperalgesia induced by repeated psychological stress in rats. Am J Physiol Gastrointest Liver Physiol. 2008 Apr; 294(4):G1033-40. PMID: 18308857.
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    144. Mayer EA, Tillisch K. Is lansoprazole effective for the initial management of young patients with dyspepsia? Nat Clin Pract Gastroenterol Hepatol. 2008 Apr; 5(4):200-1. PMID: 18285815.
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    145. Berman SM, Naliboff BD, Suyenobu B, Labus JS, Stains J, Ohning G, Kilpatrick L, Bueller JA, Ruby K, Jarcho J, Mayer EA. Reduced brainstem inhibition during anticipated pelvic visceral pain correlates with enhanced brain response to the visceral stimulus in women with irritable bowel syndrome. J Neurosci. 2008 Jan 09; 28(2):349-59. PMID: 18184777.
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    146. Fass R, Naliboff BD, Fass SS, Peleg N, Wendel C, Malagon IB, Mayer EA. The effect of auditory stress on perception of intraesophageal acid in patients with gastroesophageal reflux disease. Gastroenterology. 2008 Mar; 134(3):696-705. PMID: 18206149.
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    147. Bradesi S, Mayer EA. Novel therapeutic approaches in IBS. Curr Opin Pharmacol. 2007 Dec; 7(6):598-604. PMID: 18006379; PMCID: PMC3816523.
    148. Ringel Y, Drossman DA, Leserman JL, Suyenobu BY, Wilber K, Lin W, Whitehead WE, Naliboff BD, Berman S, Mayer EA. Effect of abuse history on pain reports and brain responses to aversive visceral stimulation: an FMRI study. Gastroenterology. 2008 Feb; 134(2):396-404. PMID: 18242208.
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    149. Greenspan JD, Craft RM, LeResche L, Arendt-Nielsen L, Berkley KJ, Fillingim RB, Gold MS, Holdcroft A, Lautenbacher S, Mayer EA, Mogil JS, Murphy AZ, Traub RJ. Studying sex and gender differences in pain and analgesia: a consensus report. Pain. 2007 Nov; 132 Suppl 1:S26-45. PMID: 17964077; PMCID: PMC2823483.
    150. Camilleri M, Mangel AW, Fehnel SE, Drossman DA, Mayer EA, Talley NJ. Primary endpoints for irritable bowel syndrome trials: a review of performance of endpoints. Clin Gastroenterol Hepatol. 2007 May; 5(5):534-40. PMID: 17428741.
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    151. Mayer EA. Enteric neuroscience: the dawn of a new discipline. Gastroenterology. 2007 Apr; 132(4):1217-8. PMID: 17408657.
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    152. Bremner JD, Bolus R, Mayer EA. Psychometric properties of the Early Trauma Inventory-Self Report. J Nerv Ment Dis. 2007 Mar; 195(3):211-8. PMID: 17468680; PMCID: PMC3229091.
    153. Labus JS, Mayer EA, Chang L, Bolus R, Naliboff BD. The central role of gastrointestinal-specific anxiety in irritable bowel syndrome: further validation of the visceral sensitivity index. Psychosom Med. 2007 Jan; 69(1):89-98. PMID: 17244851.
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    154. Bradesi S, Lao L, McLean PG, Winchester WJ, Lee K, Hicks GA, Mayer EA. Dual role of 5-HT3 receptors in a rat model of delayed stress-induced visceral hyperalgesia. Pain. 2007 Jul; 130(1-2):56-65. PMID: 17161536.
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    155. Mayer EA, Naliboff BD, Craig AD. Neuroimaging of the brain-gut axis: from basic understanding to treatment of functional GI disorders. Gastroenterology. 2006 Dec; 131(6):1925-42. PMID: 17188960.
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    156. Mayer EA. Commentary on peripheral and central contributions to hyperalgesia in irritable bowel syndrome. J Pain. 2006 Aug; 7(8):539-41; discussion 542-3. PMID: 16885009.
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    157. Naliboff BD, Berman S, Suyenobu B, Labus JS, Chang L, Stains J, Mandelkern MA, Mayer EA. Longitudinal change in perceptual and brain activation response to visceral stimuli in irritable bowel syndrome patients. Gastroenterology. 2006 Aug; 131(2):352-65. PMID: 16890589.
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    158. Bradesi S, Kokkotou E, Simeonidis S, Patierno S, Ennes HS, Mittal Y, McRoberts JA, Ohning G, McLean P, Marvizon JC, Sternini C, Pothoulakis C, Mayer EA. The role of neurokinin 1 receptors in the maintenance of visceral hyperalgesia induced by repeated stress in rats. Gastroenterology. 2006 May; 130(6):1729-42. PMID: 16697737.
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    159. Bradesi S, Tillisch K, Mayer E. Emerging drugs for irritable bowel syndrome. Expert Opin Emerg Drugs. 2006 May; 11(2):293-313. PMID: 16634703.
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    160. Berman SM, Naliboff BD, Suyenobu B, Labus JS, Stains J, Bueller JA, Ruby K, Mayer EA. Sex differences in regional brain response to aversive pelvic visceral stimuli. Am J Physiol Regul Integr Comp Physiol. 2006 Aug; 291(2):R268-76. PMID: 16614061.
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    161. Clouse RE, Mayer EA, Aziz Q, Drossman DA, Dumitrascu DL, Mönnikes H, Naliboff BD. Functional abdominal pain syndrome. Gastroenterology. 2006 Apr; 130(5):1492-7. PMID: 16678562.
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    162. Chang L, Mayer EA, Labus JS, Schmulson M, Lee OY, Olivas TI, Stains J, Naliboff BD. Effect of sex on perception of rectosigmoid stimuli in irritable bowel syndrome. Am J Physiol Regul Integr Comp Physiol. 2006 Aug; 291(2):R277-84. PMID: 16574882.
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    163. Li J, McRoberts JA, Ennes HS, Trevisani M, Nicoletti P, Mittal Y, Mayer EA. Experimental colitis modulates the functional properties of NMDA receptors in dorsal root ganglia neurons. Am J Physiol Gastrointest Liver Physiol. 2006 Aug; 291(2):G219-28. PMID: 16565418.
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    164. Naliboff BD, Mayer EA. Brain imaging in IBS: drawing the line between cognitive and non-cognitive processes. Gastroenterology. 2006 Jan; 130(1):267-70. PMID: 16401488.
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    165. Spiegel BM, Gralnek IM, Bolus R, Chang L, Dulai GS, Naliboff B, Mayer EA. Is a negative colonoscopy associated with reassurance or improved health-related quality of life in irritable bowel syndrome? Gastrointest Endosc. 2005 Dec; 62(6):892-9. PMID: 16301033.
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    166. Tillisch K, Mayer EA. Pain perception in irritable bowel syndrome. CNS Spectr. 2005 Nov; 10(11):877-82. PMID: 16273016.
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    167. Spiegel BM, Kanwal F, Naliboff B, Mayer E. The impact of somatization on the use of gastrointestinal health-care resources in patients with irritable bowel syndrome. Am J Gastroenterol. 2005 Oct; 100(10):2262-73. PMID: 16181379.
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    168. Schwetz I, McRoberts JA, Coutinho SV, Bradesi S, Gale G, Fanselow M, Million M, Ohning G, Taché Y, Plotsky PM, Mayer EA. Corticotropin-releasing factor receptor 1 mediates acute and delayed stress-induced visceral hyperalgesia in maternally separated Long-Evans rats. Am J Physiol Gastrointest Liver Physiol. 2005 Oct; 289(4):G704-12. PMID: 15994424.
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    169. Mayer EA, Berman S, Suyenobu B, Labus J, Mandelkern MA, Naliboff BD, Chang L. Differences in brain responses to visceral pain between patients with irritable bowel syndrome and ulcerative colitis. Pain. 2005 Jun; 115(3):398-409. PMID: 15911167.
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    170. Longstreth GF, Bolus R, Naliboff B, Chang L, Kulich KR, Carlsson J, Mayer EA, Naesdal J, Wiklund IK. Impact of irritable bowel syndrome on patients' lives: development and psychometric documentation of a disease-specific measure for use in clinical trials. Eur J Gastroenterol Hepatol. 2005 Apr; 17(4):411-20. PMID: 15756093.
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    171. Tillisch K, Labus JS, Naliboff BD, Bolus R, Shetzline M, Mayer EA, Chang L. Characterization of the alternating bowel habit subtype in patients with irritable bowel syndrome. Am J Gastroenterol. 2005 Apr; 100(4):896-904. PMID: 15784038.
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    172. Bradesi S, Schwetz I, Ennes HS, Lamy CM, Ohning G, Fanselow M, Pothoulakis C, McRoberts JA, Mayer EA. Repeated exposure to water avoidance stress in rats: a new model for sustained visceral hyperalgesia. Am J Physiol Gastrointest Liver Physiol. 2005 Jul; 289(1):G42-53. PMID: 15746211.
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    173. Chang L, Ameen VZ, Dukes GE, McSorley DJ, Carter EG, Mayer EA. A dose-ranging, phase II study of the efficacy and safety of alosetron in men with diarrhea-predominant IBS. Am J Gastroenterol. 2005 Jan; 100(1):115-23. PMID: 15654790.
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    174. Mayer EA, Berman S, Chang L, Naliboff BD. Sex-based differences in gastrointestinal pain. Eur J Pain. 2004 Oct; 8(5):451-63. PMID: 15324776.
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    175. Gralnek IM, Hays RD, Kilbourne AM, Chang L, Mayer EA. Racial differences in the impact of irritable bowel syndrome on health-related quality of life. J Clin Gastroenterol. 2004 Oct; 38(9):782-9. PMID: 15365405.
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    176. Spiegel BM, Gralnek IM, Bolus R, Chang L, Dulai GS, Mayer EA, Naliboff B. Clinical determinants of health-related quality of life in patients with irritable bowel syndrome. Arch Intern Med. 2004 Sep 13; 164(16):1773-80. PMID: 15364671.
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    177. Li J, McRoberts JA, Nie J, Ennes HS, Mayer EA. Electrophysiological characterization of N-methyl-D-aspartate receptors in rat dorsal root ganglia neurons. Pain. 2004 Jun; 109(3):443-52. PMID: 15157705.
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    178. Mayer EA. Inflammation in irritable bowel syndrome: curiosity or culprit. J Pediatr Gastroenterol Nutr. 2004 Jun; 39 Suppl 3:S751-3. PMID: 15167375.
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    179. Tan S, Tillisch K, Mayer E. Functional Somatic Syndromes: Emerging Biomedical Models and Traditional Chinese Medicine. Evid Based Complement Alternat Med. 2004 Jun 01; 1(1):35-40. PMID: 15257324.
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    180. Amadesi S, Nie J, Vergnolle N, Cottrell GS, Grady EF, Trevisani M, Manni C, Geppetti P, McRoberts JA, Ennes H, Davis JB, Mayer EA, Bunnett NW. Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia. J Neurosci. 2004 May 05; 24(18):4300-12. PMID: 15128844.
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    181. Lieberman MD, Jarcho JM, Berman S, Naliboff BD, Suyenobu BY, Mandelkern M, Mayer EA. The neural correlates of placebo effects: a disruption account. Neuroimage. 2004 May; 22(1):447-55. PMID: 15110038.
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    182. Naliboff BD, Mayer M, Fass R, Fitzgerald LZ, Chang L, Bolus R, Mayer EA. The effect of life stress on symptoms of heartburn. Psychosom Med. 2004 May-Jun; 66(3):426-34. PMID: 15184707.
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    183. Hazlett-Stevens H, Craske MG, Mayer EA, Chang L, Naliboff BD. Prevalence of irritable bowel syndrome among university students: the roles of worry, neuroticism, anxiety sensitivity and visceral anxiety. J Psychosom Res. 2003 Dec; 55(6):501-5. PMID: 14642979.
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    184. Schwetz I, Bradesi S, McRoberts JA, Sablad M, Miller JC, Zhou H, Ohning G, Mayer EA. Delayed stress-induced colonic hypersensitivity in male Wistar rats: role of neurokinin-1 and corticotropin-releasing factor-1 receptors. Am J Physiol Gastrointest Liver Physiol. 2004 Apr; 286(4):G683-91. PMID: 14615283.
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    185. Mayer EA, Bradesi S. Alosetron and irritable bowel syndrome. Expert Opin Pharmacother. 2003 Nov; 4(11):2089-98. PMID: 14596662.
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    186. Mayer EA. Collaborative health for IBS. Clin Gastroenterol Hepatol. 2003 Nov; 1(6):423-4. PMID: 15017640.
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    187. Mayer EA, Fanselow MS. Dissecting the components of the central response to stress. Nat Neurosci. 2003 Oct; 6(10):1011-2. PMID: 14513035.
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    188. Million M, Grigoriadis DE, Sullivan S, Crowe PD, McRoberts JA, Zhou H, Saunders PR, Maillot C, Mayer EA, Taché Y. A novel water-soluble selective CRF1 receptor antagonist, NBI 35965, blunts stress-induced visceral hyperalgesia and colonic motor function in rats. Brain Res. 2003 Sep 19; 985(1):32-42. PMID: 12957366.
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    189. Schwetz I, Bradesi S, Mayer EA. Current insights into the pathophysiology of irritable bowel syndrome. Curr Gastroenterol Rep. 2003 Aug; 5(4):331-6. PMID: 12864964.
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    190. Bradesi S, McRoberts JA, Anton PA, Mayer EA. Inflammatory bowel disease and irritable bowel syndrome: separate or unified? Curr Opin Gastroenterol. 2003 Jul; 19(4):336-42. PMID: 15703574.
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    191. Naliboff BD, Berman S, Chang L, Derbyshire SW, Suyenobu B, Vogt BA, Mandelkern M, Mayer EA. Sex-related differences in IBS patients: central processing of visceral stimuli. Gastroenterology. 2003 Jun; 124(7):1738-47. PMID: 12806606.
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    192. Chang L, Berman S, Mayer EA, Suyenobu B, Derbyshire S, Naliboff B, Vogt B, FitzGerald L, Mandelkern MA. Brain responses to visceral and somatic stimuli in patients with irritable bowel syndrome with and without fibromyalgia. Am J Gastroenterol. 2003 Jun; 98(6):1354-61. PMID: 12818281.
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    193. Dickhaus B, Mayer EA, Firooz N, Stains J, Conde F, Olivas TI, Fass R, Chang L, Mayer M, Naliboff BD. Irritable bowel syndrome patients show enhanced modulation of visceral perception by auditory stress. Am J Gastroenterol. 2003 Jan; 98(1):135-43. PMID: 12526949.
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    194. Sach J, Bolus R, Fitzgerald L, Naliboff BD, Chang L, Mayer EA. Is there a difference between abdominal pain and discomfort in moderate to severe IBS patients? Am J Gastroenterol. 2002 Dec; 97(12):3131-8. PMID: 12492200.
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    195. Drossman DA, Camilleri M, Mayer EA, Whitehead WE. AGA technical review on irritable bowel syndrome. Gastroenterology. 2002 Dec; 123(6):2108-31. PMID: 12454866.
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    196. Berman SM, Naliboff BD, Chang L, Fitzgerald L, Antolin T, Camplone A, Mayer EA. Enhanced preattentive central nervous system reactivity in irritable bowel syndrome. Am J Gastroenterol. 2002 Nov; 97(11):2791-7. PMID: 12425550.
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    197. Berman SM, Chang L, Suyenobu B, Derbyshire SW, Stains J, Fitzgerald L, Mandelkern M, Hamm L, Vogt B, Naliboff BD, Mayer EA. Condition-specific deactivation of brain regions by 5-HT3 receptor antagonist Alosetron. Gastroenterology. 2002 Oct; 123(4):969-77. PMID: 12360456.
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    198. Gschossmann JM, Adam B, Liebregts T, Buenger L, Ruwe M, Gerken G, Mayer EA, Holtmann G. Effect of transient chemically induced colitis on the visceromotor response to mechanical colorectal distension. Eur J Gastroenterol Hepatol. 2002 Oct; 14(10):1067-72. PMID: 12362096.
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    199. Mayer EA, Collins SM. Evolving pathophysiologic models of functional gastrointestinal disorders. Gastroenterology. 2002 Jun; 122(7):2032-48. PMID: 12055608.
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    200. Marvizón JC, McRoberts JA, Ennes HS, Song B, Wang X, Jinton L, Corneliussen B, Mayer EA. Two N-methyl-D-aspartate receptors in rat dorsal root ganglia with different subunit composition and localization. J Comp Neurol. 2002 May 13; 446(4):325-41. PMID: 11954032.
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    201. Mayer EA, Naliboff BD, Chang L. Evolving pathophysiological model of functional gastrointestinal disorders: implications for treatment. Eur J Surg Suppl. 2002; (587):3-9. PMID: 16144195.
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