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Wright Ernest

Title(s)Professor, Physiology
Phone310-825-6905
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    Collapse Research 
    Collapse Research Activities and Funding
    Role of SGLTs in Glucose Homeostasis and Tissue Metabolism
    NIH/NIDDK R01DK077133Apr 1, 2008 - Mar 31, 2013
    Role: Principal Investigator
    Molecular Architecture of the Na+/Glucose Cotransporter
    NIH/NIDDK R01DK044602Sep 30, 1992 - May 31, 2007
    Role: Principal Investigator
    FAMILIAL GLUCOSE GALACTOSE MALABSORPTION
    NIH/NIDDK R01DK044582Sep 30, 1992 - May 31, 2003
    Role: Principal Investigator
    STRUCTURE AND FUNCTIONS OF NA/GLUCOSE COTRANSPORTERS
    NIH/NIDDK R01DK036700May 1, 1986 - Apr 30, 1991
    Role: Principal Investigator
    PHYSIOLOGY STUDY SECTION
    NIH/CSR R09RG010769Jul 1, 1983 - Jun 30, 1986
    Role: Principal Investigator
    THE SECRETION OF CEREBROSPINAL FLUID
    NIH/NINDS R01NS009666Mar 1, 1979 - Jun 30, 1994
    Role: Principal Investigator
    Molecular Mechanisms of Intestinal Transport
    NIH/NIDDK R01DK019567Dec 1, 1976 - Apr 30, 2014
    Role: Principal Investigator
    MOLECULAR MECHANISMS OF INTESTINAL TRANSPORT
    NIH/NIADDK R01AM019567Dec 1, 1976 - Nov 30, 1988
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Bisignano P, Ghezzi C, Jo H, Polizzi NF, Althoff T, Kalyanaraman C, Friemann R, Jacobson MP, Wright EM, Grabe M. Inhibitor binding mode and allosteric regulation of Na+-glucose symporters. Nat Commun. 2018 12 07; 9(1):5245. PMID: 30532032.
      View in: PubMed
    2. Ghezzi C, Loo DDF, Wright EM. Physiology of renal glucose handling via SGLT1, SGLT2 and GLUT2. Diabetologia. 2018 10; 61(10):2087-2097. PMID: 30132032.
      View in: PubMed
    3. Sala-Rabanal M, Ghezzi C, Hirayama BA, Kepe V, Liu J, Barrio JR, Wright EM. Intestinal absorption of glucose in mice as determined by positron emission tomography. J Physiol. 2018 Jul; 596(13):2473-2489. PMID: 29707805.
      View in: PubMed
    4. Kepe V, Scafoglio C, Liu J, Yong WH, Bergsneider M, Huang SC, Barrio JR, Wright EM. Positron emission tomography of sodium glucose cotransport activity in high grade astrocytomas. J Neurooncol. 2018 Jul; 138(3):557-569. PMID: 29525972.
      View in: PubMed
    5. Paz A, Claxton DP, Kumar JP, Kazmier K, Bisignano P, Sharma S, Nolte SA, Liwag TM, Nayak V, Wright EM, Grabe M, Mchaourab HS, Abramson J. Conformational transitions of the sodium-dependent sugar transporter, vSGLT. Proc Natl Acad Sci U S A. 2018 03 20; 115(12):E2742-E2751. PMID: 29507231.
      View in: PubMed
    6. Wright EM, Ghezzi C, Loo DDF. Novel and Unexpected Functions of SGLTs. Physiology (Bethesda). 2017 11; 32(6):435-443. PMID: 29021363.
      View in: PubMed
    7. Gorraitz E, Hirayama BA, Paz A, Wright EM, Loo DDF. Active site voltage clamp fluorometry of the sodium glucose cotransporter hSGLT1. Proc Natl Acad Sci U S A. 2017 11 14; 114(46):E9980-E9988. PMID: 29087341.
      View in: PubMed
    8. Zeuthen T, Gorraitz E, Her K, Wright EM, Loo DD. Structural and functional significance of water permeation through cotransporters. Proc Natl Acad Sci U S A. 2016 11 01; 113(44):E6887-E6894. PMID: 27791155.
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    9. Ghezzi C, Yu AS, Hirayama BA, Kepe V, Liu J, Scafoglio C, Powell DR, Huang SC, Satyamurthy N, Barrio JR, Wright EM. Dapagliflozin Binds Specifically to Sodium-Glucose Cotransporter 2 in the Proximal Renal Tubule. J Am Soc Nephrol. 2017 Mar; 28(3):802-810. PMID: 27620988.
      View in: PubMed
    10. Adelman JL, Ghezzi C, Bisignano P, Loo DD, Choe S, Abramson J, Rosenberg JM, Wright EM, Grabe M. Stochastic steps in secondary active sugar transport. Proc Natl Acad Sci U S A. 2016 07 05; 113(27):E3960-6. PMID: 27325773; PMCID: PMC4941443 [Available on 01/05/17].
    11. Sala-Rabanal M, Hirayama BA, Ghezzi C, Liu J, Huang SC, Kepe V, Koepsell H, Yu A, Powell DR, Thorens B, Wright EM, Barrio JR. Revisiting the physiological roles of SGLTs and GLUTs using positron emission tomography in mice. J Physiol. 2016 08 01; 594(15):4425-38. PMID: 27018980.
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    12. Scafoglio C, Hirayama BA, Kepe V, Liu J, Ghezzi C, Satyamurthy N, Moatamed NA, Huang J, Koepsell H, Barrio JR, Wright EM. Functional expression of sodium-glucose transporters in cancer. Proc Natl Acad Sci U S A. 2015 Jul 28; 112(30):E4111-9. PMID: 26170283.
      View in: PubMed
    13. Gallo LA, Wright EM, Vallon V. Probing SGLT2 as a therapeutic target for diabetes: basic physiology and consequences. Diab Vasc Dis Res. 2015 Mar; 12(2):78-89. PMID: 25616707.
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    14. Ghezzi C, Hirayama BA, Gorraitz E, Loo DD, Liang Y, Wright EM. SGLT2 inhibitors act from the extracellular surface of the cell membrane. Physiol Rep. 2014 Jun 01; 2(6). PMID: 24973332.
      View in: PubMed
    15. Adelman JL, Sheng Y, Choe S, Abramson J, Wright EM, Rosenberg JM, Grabe M. Structural determinants of water permeation through the sodium-galactose transporter vSGLT. Biophys J. 2014 Mar 18; 106(6):1280-9. PMID: 24655503; PMCID: PMC3984995.
    16. Ghezzi C, Gorraitz E, Hirayama BA, Loo DD, Grempler R, Mayoux E, Wright EM. Fingerprints of hSGLT5 sugar and cation selectivity. Am J Physiol Cell Physiol. 2014 May 01; 306(9):C864-70. PMID: 24573086.
      View in: PubMed
    17. Loo DD, Jiang X, Gorraitz E, Hirayama BA, Wright EM. Functional identification and characterization of sodium binding sites in Na symporters. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):E4557-66. PMID: 24191006; PMCID: PMC3839715.
    18. Wright EM. Glucose transport families SLC5 and SLC50. Mol Aspects Med. 2013 Apr-Jun; 34(2-3):183-96. PMID: 23506865.
      View in: PubMed
    19. Yu AS, Hirayama BA, Timbol G, Liu J, Diez-Sampedro A, Kepe V, Satyamurthy N, Huang SC, Wright EM, Barrio JR. Regional distribution of SGLT activity in rat brain in vivo. Am J Physiol Cell Physiol. 2013 Feb 01; 304(3):C240-7. PMID: 23151803; PMCID: PMC3566441.
    20. Jiang X, Loo DD, Hirayama BA, Wright EM. The importance of being aromatic: p interactions in sodium symporters. Biochemistry. 2012 Nov 27; 51(47):9480-7. PMID: 23116249; PMCID: PMC3523751.
    21. Ghezzi C, Wright EM. Regulation of the human Na+-dependent glucose cotransporter hSGLT2. Am J Physiol Cell Physiol. 2012 Aug 01; 303(3):C348-54. PMID: 22673616; PMCID: PMC3423026.
    22. Sala-Rabanal M, Hirayama BA, Loo DD, Chaptal V, Abramson J, Wright EM. Bridging the gap between structure and kinetics of human SGLT1. Am J Physiol Cell Physiol. 2012 May 01; 302(9):C1293-305. PMID: 22159082; PMCID: PMC3361952.
    23. Hummel CS, Lu C, Liu J, Ghezzi C, Hirayama BA, Loo DD, Kepe V, Barrio JR, Wright EM. Structural selectivity of human SGLT inhibitors. Am J Physiol Cell Physiol. 2012 Jan 15; 302(2):C373-82. PMID: 21940664.
      View in: PubMed
    24. Wright EM, Loo DD, Hirayama BA. Biology of human sodium glucose transporters. Physiol Rev. 2011 Apr; 91(2):733-94. PMID: 21527736.
      View in: PubMed
    25. Zampighi GA, Schietroma C, Zampighi LM, Woodruff M, Wright EM, Brecha NC. Conical tomography of a ribbon synapse: structural evidence for vesicle fusion. PLoS One. 2011 Mar 01; 6(3):e16944. PMID: 21390245.
      View in: PubMed
    26. Watanabe A, Choe S, Chaptal V, Rosenberg JM, Wright EM, Grabe M, Abramson J. The mechanism of sodium and substrate release from the binding pocket of vSGLT. Nature. 2010 Dec 16; 468(7326):988-91. PMID: 21131949; PMCID: PMC3736980.
    27. Hummel CS, Lu C, Loo DD, Hirayama BA, Voss AA, Wright EM. Glucose transport by human renal Na+/D-glucose cotransporters SGLT1 and SGLT2. Am J Physiol Cell Physiol. 2011 Jan; 300(1):C14-21. PMID: 20980548; PMCID: PMC3023189.
    28. Choe S, Rosenberg JM, Abramson J, Wright EM, Grabe M. Water permeation through the sodium-dependent galactose cotransporter vSGLT. Biophys J. 2010 Oct 06; 99(7):L56-8. PMID: 20923633.
      View in: PubMed
    29. Yu AS, Hirayama BA, Timbol G, Liu J, Basarah E, Kepe V, Satyamurthy N, Huang SC, Wright EM, Barrio JR. Functional expression of SGLTs in rat brain. Am J Physiol Cell Physiol. 2010 Dec; 299(6):C1277-84. PMID: 20826762.
      View in: PubMed
    30. Abramson J, Wright EM. Structure and function of Na(+)-symporters with inverted repeats. Curr Opin Struct Biol. 2009 Aug; 19(4):425-32. PMID: 19631523; PMCID: PMC3496787.
    31. Bakris GL, Fonseca VA, Sharma K, Wright EM. Renal sodium-glucose transport: role in diabetes mellitus and potential clinical implications. Kidney Int. 2009 Jun; 75(12):1272-1277. PMID: 19357717.
      View in: PubMed
    32. Faham S, Watanabe A, Besserer GM, Cascio D, Specht A, Hirayama BA, Wright EM, Abramson J. The crystal structure of a sodium galactose transporter reveals mechanistic insights into Na+/sugar symport. Science. 2008 Aug 08; 321(5890):810-4. PMID: 18599740.
      View in: PubMed
    33. Loo DD, Hirayama BA, Sala-Rabanal M, Wright EM. How drugs interact with transporters: SGLT1 as a model. J Membr Biol. 2008 May; 223(2):87-106. PMID: 18592293.
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    34. Zampighi GA, Fain N, Zampighi LM, Cantele F, Lanzavecchia S, Wright EM. Conical electron tomography of a chemical synapse: polyhedral cages dock vesicles to the active zone. J Neurosci. 2008 Apr 16; 28(16):4151-60. PMID: 18417694.
      View in: PubMed
    35. Sala-Rabanal M, Loo DD, Hirayama BA, Wright EM. Molecular mechanism of dipeptide and drug transport by the human renal H+/oligopeptide cotransporter hPEPT2. Am J Physiol Renal Physiol. 2008 Jun; 294(6):F1422-32. PMID: 18367661.
      View in: PubMed
    36. Hirayama BA, Loo DD, Díez-Sampedro A, Leung DW, Meinild AK, Lai-Bing M, Turk E, Wright EM. Sodium-dependent reorganization of the sugar-binding site of SGLT1. Biochemistry. 2007 Nov 20; 46(46):13391-406. PMID: 17960916.
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    37. Wright EM, Hirayama BA, Loo DF. Active sugar transport in health and disease. J Intern Med. 2007 Jan; 261(1):32-43. PMID: 17222166.
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    38. Loo DD, Hirayama BA, Karakossian MH, Meinild AK, Wright EM. Conformational dynamics of hSGLT1 during Na+/glucose cotransport. J Gen Physiol. 2006 Dec; 128(6):701-20. PMID: 17130520; PMCID: PMC2151600.
    39. Voss AA, Díez-Sampedro A, Hirayama BA, Loo DD, Wright EM. Imino sugars are potent agonists of the human glucose sensor SGLT3. Mol Pharmacol. 2007 Feb; 71(2):628-34. PMID: 17110502.
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    40. Sala-Rabanal M, Loo DD, Hirayama BA, Turk E, Wright EM. Molecular interactions between dipeptides, drugs and the human intestinal H+ -oligopeptide cotransporter hPEPT1. J Physiol. 2006 Jul 01; 574(Pt 1):149-66. PMID: 16627568.
      View in: PubMed
    41. Turk E, Gasymov OK, Lanza S, Horwitz J, Wright EM. A reinvestigation of the secondary structure of functionally active vSGLT, the vibrio sodium/galactose cotransporter. Biochemistry. 2006 Feb 07; 45(5):1470-9. PMID: 16445289.
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    42. Loo DD, Hirayama BA, Cha A, Bezanilla F, Wright EM. Perturbation analysis of the voltage-sensitive conformational changes of the Na+/glucose cotransporter. J Gen Physiol. 2005 Jan; 125(1):13-36. PMID: 15596535; PMCID: PMC2217483.
    43. Wright EM, Loo DD, Hirayama BA, Turk E. Surprising versatility of Na+-glucose cotransporters: SLC5. Physiology (Bethesda). 2004 Dec; 19:370-6. PMID: 15546855.
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    44. Díez-Sampedro A, Loo DD, Wright EM, Zampighi GA, Hirayama BA. Coupled sodium/glucose cotransport by SGLT1 requires a negative charge at position 454. Biochemistry. 2004 Oct 19; 43(41):13175-84. PMID: 15476411.
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    45. Veenstra M, Lanza S, Hirayama BA, Turk E, Wright EM. Local conformational changes in the Vibrio Na+/galactose cotransporter. Biochemistry. 2004 Mar 30; 43(12):3620-7. PMID: 15035632.
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    46. Wright EM, Martín MG, Turk E. Intestinal absorption in health and disease--sugars. Best Pract Res Clin Gastroenterol. 2003 Dec; 17(6):943-56. PMID: 14642859.
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    47. Diez-Sampedro A, Hirayama BA, Osswald C, Gorboulev V, Baumgarten K, Volk C, Wright EM, Koepsell H. A glucose sensor hiding in a family of transporters. Proc Natl Acad Sci U S A. 2003 Sep 30; 100(20):11753-8. PMID: 13130073; PMCID: PMC208830.
    48. Quick M, Tomasevic J, Wright EM. Functional asymmetry of the human Na+/glucose transporter (hSGLT1) in bacterial membrane vesicles. Biochemistry. 2003 Aug 05; 42(30):9147-52. PMID: 12885248.
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    49. Wright EM, Turk E. The sodium/glucose cotransport family SLC5. Pflugers Arch. 2004 Feb; 447(5):510-8. PMID: 12748858.
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    50. Zampighi GA, Kreman M, Lanzavecchia S, Turk E, Eskandari S, Zampighi L, Wright EM. Structure of functional single AQP0 channels in phospholipid membranes. J Mol Biol. 2003 Jan 03; 325(1):201-10. PMID: 12473462.
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    51. Sarkar HK, Wright EM, Boorer KJ, Loo DD. Electrophysiological properties of the mouse Na+/Cl(-)-dependent taurine transporter (mTauT-1): steady-state kinetics: stoichiometry of taurine transport. Adv Exp Med Biol. 2003; 526:197-204. PMID: 12908601.
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    52. Loo DD, Wright EM, Zeuthen T. Water pumps. J Physiol. 2002 Jul 01; 542(Pt 1):53-60. PMID: 12096049; PMCID: PMC2290409.
    53. le Coutre J, Turk E, Kaback HR, Wright EM. Ligand-induced differences in secondary structure of the Vibrio parahaemolyticus Na+/galactose cotransporter. Biochemistry. 2002 Jun 25; 41(25):8082-6. PMID: 12069600.
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    54. Quick M, Wright EM. Employing Escherichia coli to functionally express, purify, and characterize a human transporter. Proc Natl Acad Sci U S A. 2002 Jun 25; 99(13):8597-601. PMID: 12077304; PMCID: PMC124325.
    55. Fischer WN, Loo DD, Koch W, Ludewig U, Boorer KJ, Tegeder M, Rentsch D, Wright EM, Frommer WB. Low and high affinity amino acid H+-cotransporters for cellular import of neutral and charged amino acids. Plant J. 2002 Mar; 29(6):717-31. PMID: 12148530.
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    56. Meinild AK, Hirayama BA, Wright EM, Loo DD. Fluorescence studies of ligand-induced conformational changes of the Na(+)/glucose cotransporter. Biochemistry. 2002 Jan 29; 41(4):1250-8. PMID: 11802724.
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    57. Wright EM, Turk E, Martin MG. Molecular basis for glucose-galactose malabsorption. Cell Biochem Biophys. 2002; 36(2-3):115-21. PMID: 12139397.
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    58. Wright EM. Renal Na(+)-glucose cotransporters. Am J Physiol Renal Physiol. 2001 Jan; 280(1):F10-8. PMID: 11133510.
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    59. Wright EM, Loo DD. Coupling between Na+, sugar, and water transport across the intestine. Ann N Y Acad Sci. 2000; 915:54-66. PMID: 11193601.
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    60. Loo DD, Wright EM, Meinild AK, Klaerke DA, Zeuthen T. Commentary on "Epithelial Fluid Transport--A Century of Investigation" News Physiol Sci. 1999 Jun; 14:98-100. PMID: 11390830.
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