Thomas Gail

Title(s)Member, CTSI
Phone(310) 248-8024
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    Other Positions
    Title(s)Member, Center for Duchenne Muscular Dystrophy

    Collapse Research 
    Collapse Research Activities and Funding
    NRSA Training Core
    NIH/NCATS TL1TR002016Sep 12, 2016 - May 31, 2020
    Role: Principal Investigator
    Golgi-associated NO-cGMP Signaling Defect in Muscular Dystrophy
    NIH/NIAMS R01AR056221Sep 25, 2009 - Jul 31, 2014
    Role: Co-Principal Investigator
    Ischemia and the Pathogenesis of Muscular Dystrophy
    NIH/NIAMS R01AR051034May 1, 2004 - Oct 31, 2009
    Role: Principal Investigator
    NIH/NHLBI R01HL064784May 1, 2000 - Apr 30, 2005
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Kuczmarski JM, Unrath K, Thomas GD. Exaggerated cardiovascular responses to treadmill running in rats with peripheral arterial insufficiency. Am J Physiol Heart Circ Physiol. 2018 01 01; 314(1):H114-H121. PMID: 28986360.
      View in: PubMed
    2. Harms JE, Kuczmarski JM, Kim JS, Thomas GD, Kaufman MP. The role played by oxidative stress in evoking the exercise pressor reflex in health and simulated peripheral artery disease. J Physiol. 2017 07 01; 595(13):4365-4378. PMID: 28369936.
      View in: PubMed
    3. Thomas GD. Functional sympatholysis in hypertension. Auton Neurosci. 2015 Mar; 188:64-8. PMID: 25458424; PMCID: PMC4336594.
    4. Thomas GD. Functional muscle ischemia in Duchenne and Becker muscular dystrophy. Front Physiol. 2013 Dec 18; 4:381. PMID: 24391598; PMCID: PMC3866652.
    5. Zhang Y, Yue Y, Li L, Hakim CH, Zhang K, Thomas GD, Duan D. Dual AAV therapy ameliorates exercise-induced muscle injury and functional ischemia in murine models of Duchenne muscular dystrophy. Hum Mol Genet. 2013 Sep 15; 22(18):3720-9. PMID: 23681067; PMCID: PMC3749861.
    6. Price A, Raheja P, Wang Z, Arbique D, Adams-Huet B, Mitchell JH, Victor RG, Thomas GD, Vongpatanasin W. Differential effects of nebivolol versus metoprolol on functional sympatholysis in hypertensive humans. Hypertension. 2013 Jun; 61(6):1263-9. PMID: 23547240; PMCID: PMC3785406.
    7. Martin EA, Barresi R, Byrne BJ, Tsimerinov EI, Scott BL, Walker AE, Gurudevan SV, Anene F, Elashoff RM, Thomas GD, Victor RG. Tadalafil alleviates muscle ischemia in patients with Becker muscular dystrophy. Sci Transl Med. 2012 Nov 28; 4(162):162ra155. PMID: 23197572; PMCID: PMC3935430.
    8. Thomas GD, Ye J, De Nardi C, Monopoli A, Ongini E, Victor RG. Treatment with a nitric oxide-donating NSAID alleviates functional muscle ischemia in the mouse model of Duchenne muscular dystrophy. PLoS One. 2012; 7(11):e49350. PMID: 23139842; PMCID: PMC3489726.
    9. Fadel PJ, Farias Iii M, Gallagher KM, Wang Z, Thomas GD. Oxidative stress and enhanced sympathetic vasoconstriction in contracting muscles of nitrate-tolerant rats and humans. J Physiol. 2012 Jan 15; 590(2):395-407. PMID: 22106180; PMCID: PMC3285073.
    10. Thomas GD. Neural control of the circulation. Adv Physiol Educ. 2011 Mar; 35(1):28-32. PMID: 21385998.
      View in: PubMed
    11. Vongpatanasin W, Wang Z, Arbique D, Arbique G, Adams-Huet B, Mitchell JH, Victor RG, Thomas GD. Functional sympatholysis is impaired in hypertensive humans. J Physiol. 2011 Mar 01; 589(Pt 5):1209-20. PMID: 21224235; PMCID: PMC3060597.
    12. Thomas GD. Ready, set, flow! But how does the flow know where to go? J Physiol. 2010 Oct 01; 588(Pt 19):3633-4. PMID: 20889489; PMCID: PMC2998214.
    13. Young CN, Fisher JP, Gallagher KM, Whaley-Connell A, Chaudhary K, Victor RG, Thomas GD, Fadel PJ. Inhibition of nitric oxide synthase evokes central sympatho-excitation in healthy humans. J Physiol. 2009 Oct 15; 587(Pt 20):4977-86. PMID: 19723781; PMCID: PMC2770160.
    14. Lai Y, Thomas GD, Yue Y, Yang HT, Li D, Long C, Judge L, Bostick B, Chamberlain JS, Terjung RL, Duan D. Dystrophins carrying spectrin-like repeats 16 and 17 anchor nNOS to the sarcolemma and enhance exercise performance in a mouse model of muscular dystrophy. J Clin Invest. 2009 Mar; 119(3):624-35. PMID: 19229108; PMCID: PMC2648692.
    15. Zhao W, Swanson SA, Ye J, Li X, Shelton JM, Zhang W, Thomas GD. Reactive oxygen species impair sympathetic vasoregulation in skeletal muscle in angiotensin II-dependent hypertension. Hypertension. 2006 Oct; 48(4):637-43. PMID: 16940212.
      View in: PubMed
    16. Ito K, Kimura S, Ozasa S, Matsukura M, Ikezawa M, Yoshioka K, Ueno H, Suzuki M, Araki K, Yamamura K, Miwa T, Dickson G, Thomas GD, Miike T. Smooth muscle-specific dystrophin expression improves aberrant vasoregulation in mdx mice. Hum Mol Genet. 2006 Jul 15; 15(14):2266-75. PMID: 16777842.
      View in: PubMed
    17. Augustyniak RA, Thomas GD, Victor RG, Zhang W. Nitric oxide pathway as new drug targets for refractory hypertension. Curr Pharm Des. 2005; 11(25):3307-15. PMID: 16250858.
      View in: PubMed
    18. Lambert DG, Thomas GD. {alpha}-Adrenoceptor constrictor responses and their modulation in slow-twitch and fast-twitch mouse skeletal muscle. J Physiol. 2005 Mar 15; 563(Pt 3):821-9. PMID: 15618269; PMCID: PMC1665625.
    19. Fadel PJ, Wang Z, Watanabe H, Arbique D, Vongpatanasin W, Thomas GD. Augmented sympathetic vasoconstriction in exercising forearms of postmenopausal women is reversed by oestrogen therapy. J Physiol. 2004 Dec 15; 561(Pt 3):893-901. PMID: 15498809; PMCID: PMC1665388.
    20. Thomas GD, Segal SS. Neural control of muscle blood flow during exercise. J Appl Physiol (1985). 2004 Aug; 97(2):731-8. PMID: 15247201.
      View in: PubMed
    21. Fadel PJ, Keller DM, Watanabe H, Raven PB, Thomas GD. Noninvasive assessment of sympathetic vasoconstriction in human and rodent skeletal muscle using near-infrared spectroscopy and Doppler ultrasound. J Appl Physiol (1985). 2004 Apr; 96(4):1323-30. PMID: 14657045.
      View in: PubMed
    22. Joyner MJ, Thomas GD. Having it both ways? Vasoconstriction in contracting muscles. J Physiol. 2003 Jul 15; 550(Pt 2):333. PMID: 12777450; PMCID: PMC2343057.
    23. Fadel PJ, Zhao W, Thomas GD. Impaired vasomodulation is associated with reduced neuronal nitric oxide synthase in skeletal muscle of ovariectomized rats. J Physiol. 2003 May 15; 549(Pt 1):243-53. PMID: 12665606; PMCID: PMC2342919.
    24. Fadel PJ, Wang Z, Tuncel M, Watanabe H, Abbas A, Arbique D, Vongpatanasin W, Haley RW, Victor RG, Thomas GD. Reflex sympathetic activation during static exercise is severely impaired in patients with myophosphorylase deficiency. J Physiol. 2003 May 01; 548(Pt 3):983-93. PMID: 12640006; PMCID: PMC2342887.
    25. Thomas GD, Shaul PW, Yuhanna IS, Froehner SC, Adams ME. Vasomodulation by skeletal muscle-derived nitric oxide requires alpha-syntrophin-mediated sarcolemmal localization of neuronal Nitric oxide synthase. Circ Res. 2003 Mar 21; 92(5):554-60. PMID: 12600881.
      View in: PubMed
    26. Thomas GD, Victor RG. In favor of a role of lactic acid on the generation of the exercise pressor reflex. Clin Auton Res. 2003 Feb; 13(1):5-6. PMID: 12749327.
      View in: PubMed
    27. Chavoshan B, Sander M, Sybert TE, Hansen J, Victor RG, Thomas GD. Nitric oxide-dependent modulation of sympathetic neural control of oxygenation in exercising human skeletal muscle. J Physiol. 2002 Apr 01; 540(Pt 1):377-86. PMID: 11927694; PMCID: PMC2290221.