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Mathern Gary

TitleDirector
InstitutionUniversity of California Los Angeles
DepartmentEpilepsy Surgery
Address710 Westwood Plaza
Los Angeles CA 90095
Phone(310) 825-7961
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    Other Positions
    TitleDirector

    TitleProfessor In-Residence

    TitleProfessor In-Residence


    Collapse Research 
    Collapse Research Activities and Funding
    Molecular characterization of Hemimegalencephaly
    NIH/NINDS R01NS083823Jul 1, 2013 - Jun 30, 2018
    Role: Co-Principal Investigator
    Mechanisms Altering Electrical Conductivity &DTI in Epilepsy Surgery Patients
    NIH/NINDS R21NS060675Jan 15, 2010 - Dec 31, 2012
    Role: Principal Investigator
    Cortical Plasticity after Hemispherectomy
    NIH/NICHD R21HD050707Aug 15, 2005 - Jul 31, 2008
    Role: Principal Investigator
    Pathophysiology of Developing Dysplastic Human Cortex
    NIH/NINDS R01NS038992Jul 1, 1999 - Nov 30, 2014
    Role: Principal Investigator
    MOLECULAR MECHANISMS OF MESIAL LIMBIC EPILEPSY
    NIH/NINDS R55NS036536Sep 15, 1998 - Aug 31, 2000
    Role: Principal Investigator
    SEIZURES IN HIPPOCAMPI OF EPILEPTIC CHILDREN
    NIH/NINDS K08NS001603Dec 1, 1993 - Nov 30, 1998
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Correa DJ, Kwon CS, Connors S, Fureman B, Whittemore V, Jetté N, Mathern G, Moshé SL. Applying participatory action research in traumatic brain injury studies to prevent post-traumatic epilepsy. Neurobiol Dis. 2018 Jul 18. PMID: 30031158.
      View in: PubMed
    2. Sorrells SF, Paredes MF, Cebrian-Silla A, Sandoval K, Qi D, Kelley KW, James D, Mayer S, Chang J, Auguste KI, Chang EF, Gutierrez AJ, Kriegstein AR, Mathern G, Oldham MC, Huang EJ, Garcia-Verdugo JM, Yang Z, Alvarez-Buylla A. Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults. Nature. 2018 Mar 15; 555(7696):377-381. PMID: 29513649.
      View in: PubMed
    3. Zhao X, Liao Y, Morgan S, Mathur R, Feustel P, Mazurkiewicz J, Qian J, Chang J, Mathern G, Adamo MA, Ritaccio AL, Gruenthal M, Zhu X, Huang Y. Noninflammatory Changes of Microglia Are Sufficient to Cause Epilepsy. Cell Rep. 2018 Feb 20; 22(8):2080-2093. PMID: 29466735.
      View in: PubMed
    4. D'Gama AM, Woodworth MB, Hossain AA, Bizzotto S, Hatem NE, LaCoursiere CM, Najm I, Ying Z, Yang E, Barkovich AJ, Kwiatkowski DJ, Vinters HV, Madsen JR, Mathern G, Blümcke I, Poduri A, Walsh CA. Somatic Mutations Activating the mTOR Pathway in Dorsal Telencephalic Progenitors Cause a Continuum of Cortical Dysplasias. Cell Rep. 2017 Dec 26; 21(13):3754-3766. PMID: 29281825.
      View in: PubMed
    5. Wang AC, Ibrahim GM, Poliakov AV, Wang PI, Fallah A, Mathern G, Buckley RT, Collins K, Weil AG, Shurtleff HA, Warner MH, Perez FA, Shaw DW, Wright JN, Saneto RP, Novotny EJ, Lee A, Browd SR, Ojemann JG. Corticospinal tract atrophy and motor fMRI predict motor preservation after functional cerebral hemispherectomy. J Neurosurg Pediatr. 2018 Jan; 21(1):81-89. PMID: 29099351.
      View in: PubMed
    6. Fisher RS, Acevedo C, Arzimanoglou A, Bogacz A, Cross JH, Elger CE, Engel J, Forsgren L, French JA, Hesdorffer DC, Lee BI, Mathern G, Moshe SL, Perucca E, Scheffer IE, Tomson T, Watanabe M, Wiebe S. How long for epilepsy remission in the ILAE definition? Epilepsia. 2017 08; 58(8):1486-1487. PMID: 28799662.
      View in: PubMed
    7. Hussain SA, Mathern G, Hung P, Weng J, Sankar R, Wu JY. Intraoperative fast ripples independently predict postsurgical epilepsy outcome: Comparison with other electrocorticographic phenomena. Epilepsy Res. 2017 09; 135:79-86. PMID: 28644979.
      View in: PubMed
    8. Nehlig A, Sperling M, Mathern G. An interview with Tiwalade Sobayo, 2017 Epilepsia Prize Winner for Basic Science Research. Epilepsia. 2017 07; 58(7):1115-1116. PMID: 28677858.
      View in: PubMed
    9. Nehlig A, Sperling M, Mathern G. An interview with Sarah Weckhuysen, 2017 Epilepsia Prize Winner for Clinical Research. Epilepsia. 2017 07; 58(7):1119-1120. PMID: 28677854.
      View in: PubMed
    10. Scheffer IE, Berkovic S, Capovilla G, Connolly MB, French J, Guilhoto L, Hirsch E, Jain S, Mathern G, Moshé SL, Nordli DR, Perucca E, Tomson T, Wiebe S, Zhang YH, Zuberi SM. ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology. Epilepsia. 2017 04; 58(4):512-521. PMID: 28276062.
      View in: PubMed
    11. Weiss SA, Asadi-Pooya AA, Vangala S, Moy S, Wyeth DH, Orosz I, Gibbs M, Schrader L, Lerner J, Cheng CK, Chang E, Rajaraman R, Keselman I, Churchman P, Bower-Baca C, Numis AL, Ho MG, Rao L, Bhat A, Suski J, Asadollahi M, Ambrose T, Fernandez A, Nei M, Skidmore C, Mintzer S, Eliashiv DS, Mathern G, Nuwer MR, Sperling M, Engel J, Stern JM. AR2, a novel automatic artifact reduction software method for ictal EEG interpretation: Validation and comparison of performance with commercially available software. F1000Res. 2017; 6:30. PMID: 28491280.
      View in: PubMed
    12. Dandekar S, Wijesuriya H, Geiger T, Hamm D, Mathern G, Owens GC. Shared HLA Class I and II Alleles and Clonally Restricted Public and Private Brain-Infiltrating aß T Cells in a Cohort of Rasmussen Encephalitis Surgery Patients. Front Immunol. 2016; 7:608. PMID: 28066418.
      View in: PubMed
    13. Galanopoulou AS, Schmidt D, Wang X, Mathern G. Minimizing publication bias in Epilepsia Open: Negative or confirmatory studies and preliminary reports. Epilepsia Open. 2016 Dec; 1(3-4):74-75. PMID: 29588931.
      View in: PubMed
    14. Hussain SA, Mathern G, Sankar R, Wu JY. Prospective and "live" fast ripple detection and localization in the operating room: Impact on epilepsy surgery outcomes in children. Epilepsy Res. 2016 11; 127:344-351. PMID: 27721161.
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    15. Fallah A, Weil AG, Wang S, Lewis E, Baca CB, Mathern G. Cost-utility analysis of competing treatment strategies for drug-resistant epilepsy in children with Tuberous Sclerosis Complex. Epilepsy Behav. 2016 10; 63:79-88. PMID: 27591681.
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    16. Nehlig A, Sperling M, Mathern G. An interview with Saadet Mahmutoglu, 2016 Epilepsia prize winner for Clinical Research. Epilepsia. 2016 09; 57(9):1343-4. PMID: 27522448.
      View in: PubMed
    17. Nehlig A, Sperling M, Mathern G. Interview with Lena Nguyen, 2016 Epilepsia prize winner for Basic Science Research. Epilepsia. 2016 09; 57(9):1347-8. PMID: 27522480.
      View in: PubMed
    18. Pieters HC, Iwaki T, Vickrey BG, Mathern G, Baca CB. "It was five years of hell": Parental experiences of navigating and processing the slow and arduous time to pediatric resective epilepsy surgery. Epilepsy Behav. 2016 09; 62:276-84. PMID: 27521720.
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    19. Sauro KM, Holroyd-Leduc J, Wiebe S, Quan H, Cooke L, Cross JH, Mathern G, Armson H, Stromer J, Jetté N. Knowledge translation of an online tool to determine candidacy for epilepsy surgery evaluation. Neurol Clin Pract. 2016 Aug; 6(4):304-314. PMID: 27574569.
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    20. Schmidt D, Galanopoulou AS, Mathern G, Wang X. Why Epilepsia Open? Epilepsia Open. 2016 Sep; 1(1-2):6-7. PMID: 29588923.
      View in: PubMed
    21. Scheffer IE, French J, Hirsch E, Jain S, Mathern G, Moshé SL, Perucca E, Tomson T, Wiebe S, Zhang YH, Zuberi SM. Classification of the epilepsies: New concepts for discussion and debate-Special report of the ILAE Classification Task Force of the Commission for Classification and Terminology. Epilepsia Open. 2016 Sep; 1(1-2):37-44. PMID: 29588927.
      View in: PubMed
    22. Kruse CA, Pardo CA, Hartman AL, Jallo G, Vining EP, Voros J, Gaillard WD, Liu J, Oluigbo C, Malone S, Bleasel AF, Dexter M, Micati A, Velasco TR, Machado HR, Martino AM, Huang A, Wheatley BM, Grant GA, Granata T, Freri E, Garbelli R, Koh S, Nordli DR, Campos AR, O'Neill B, Handler MH, Chapman KE, Wilfong AA, Curry DJ, Yaun A, Madsen JR, Smyth MD, Mercer D, Bingaman W, Harvey AS, Leventer RJ, Lockhart PJ, Gillies G, Pope K, Giller CA, Park YD, Rojiani AM, Sharma SJ, Jenkins P, Tung S, Huynh MN, Chirwa TW, Cepeda C, Levine MS, Chang JW, Owens GC, Vinters HV, Mathern G. Rasmussen encephalitis tissue transfer program. Epilepsia. 2016 06; 57(6):1005-7. PMID: 27286752.
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    23. Owens GC, Chang JW, Huynh MN, Chirwa T, Vinters HV, Mathern G. Evidence for Resident Memory T Cells in Rasmussen Encephalitis. Front Immunol. 2016; 7:64. PMID: 26941743; PMCID: PMC4763066.
    24. Yogi A, Hirata Y, Karavaeva E, Harris RJ, Wu JY, Yudovin SL, Linetsky M, Mathern G, Ellingson BM, Salamon N. DTI of tuber and perituberal tissue can predict epileptogenicity in tuberous sclerosis complex. Neurology. 2015 Dec 08; 85(23):2011-5. PMID: 26546629.
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    25. Baek ST, Copeland B, Yun EJ, Kwon SK, Guemez-Gamboa A, Schaffer AE, Kim S, Kang HC, Song S, Mathern G, Gleeson JG. An AKT3-FOXG1-reelin network underlies defective migration in human focal malformations of cortical development. Nat Med. 2015 Dec; 21(12):1445-54. PMID: 26523971; PMCID: PMC4955611.
    26. Ellingson BM, Hirata Y, Yogi A, Karavaeva E, Leu K, Woodworth DC, Harris RJ, Enzmann DR, Wu JY, Mathern G, Salamon N. Topographical Distribution of Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex. J Child Neurol. 2016 Apr; 31(5):636-45. PMID: 26472749.
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    27. de Bode S, Smets L, Mathern G, Dubinsky S. Complex syntax in the isolated right hemisphere: Receptive grammatical abilities after cerebral hemispherectomy. Epilepsy Behav. 2015 Oct; 51:33-9. PMID: 26253599.
      View in: PubMed
    28. Owens GC, Erickson KL, Malone CC, Pan C, Huynh MN, Chang JW, Chirwa T, Vinters HV, Mathern G, Kruse CA. Evidence for the involvement of gamma delta T cells in the immune response in Rasmussen encephalitis. J Neuroinflammation. 2015 Jul 19; 12:134. PMID: 26186920; PMCID: PMC4506578.
    29. Diamond M, Mathern G, Nehlig A, Sperling M. Interview with Matthew Diamond, 2014 Epilepsia prize winner. Epilepsia. 2015 Jul; 56(7):987-8. PMID: 26041101.
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    30. Baca CB, Pieters HC, Iwaki TJ, Mathern G, Vickrey BG. "A journey around the world": Parent narratives of the journey to pediatric resective epilepsy surgery and beyond. Epilepsia. 2015 Jun; 56(6):822-32. PMID: 25894906; PMCID: PMC4457674.
    31. de Bode S, Chanturidze M, Mathern G, Dubinsky S. Literacy after cerebral hemispherectomy: Can the isolated right hemisphere read? Epilepsy Behav. 2015 Apr; 45:248-53. PMID: 25819796.
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    32. D'Gama AM, Geng Y, Couto JA, Martin B, Boyle EA, LaCoursiere CM, Hossain A, Hatem NE, Barry BJ, Kwiatkowski DJ, Vinters HV, Barkovich AJ, Shendure J, Mathern G, Walsh CA, Poduri A. Mammalian target of rapamycin pathway mutations cause hemimegalencephaly and focal cortical dysplasia. Ann Neurol. 2015 Apr; 77(4):720-5. PMID: 25599672; PMCID: PMC4471336.
    33. Jehi L, Mathern G. Who's responsible to refer for epilepsy surgery? We all are! Neurology. 2015 Jan 13; 84(2):112-3. PMID: 25503618.
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    34. Mathern G, Beninsig L, Nehlig A. Should consciousness describe seizures and what terms should be applied? Epilepsia's survey results. Epilepsia. 2015 Mar; 56(3):340-3. PMID: 25486897.
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    35. Cepeda C, Chang JW, Owens GC, Huynh MN, Chen JY, Tran C, Vinters HV, Levine MS, Mathern G. In Rasmussen encephalitis, hemichannels associated with microglial activation are linked to cortical pyramidal neuron coupling: a possible mechanism for cellular hyperexcitability. CNS Neurosci Ther. 2015 Feb; 21(2):152-63. PMID: 25438677; PMCID: PMC4303544.
    36. Mathern G, Beninsig L, Nehlig A. Reasons for discrepancy between incidence and prevalence of epilepsy in lower income countries: Epilepsia's survey results. Epilepsia. 2015 Feb; 56(2):163-5. PMID: 25428806.
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    37. Mathern G, Beninsig L, Nehlig A. Fewer specialists support using medical marijuana and CBD in treating epilepsy patients compared with other medical professionals and patients: result of Epilepsia's survey. Epilepsia. 2015 Jan; 56(1):1-6. PMID: 25413126.
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    38. Abdijadid S, Mathern G, Levine MS, Cepeda C. Basic mechanisms of epileptogenesis in pediatric cortical dysplasia. CNS Neurosci Ther. 2015 Feb; 21(2):92-103. PMID: 25404064; PMCID: PMC4442638.
    39. Mathern G, Nehlig A. Global awareness and International Epilepsy Day. Epilepsia. 2015 Feb; 56(2):167. PMID: 25404237.
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    40. Mathern G, Beninsig L, Nehlig A. From the editors: Epilepsia's 2014 Operational Definition of Epilepsy survey. Epilepsia. 2014 Nov; 55(11):1683-7. PMID: 25382795.
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    41. Mathern G, Beninsig L, Nehlig A. From the editors: Epilepsia's survey on the necessity of the Wada test and intracranial electrodes for cortical mapping. Epilepsia. 2014 Dec; 55(12):1887-9. PMID: 25358628.
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    42. Mathern G, Nehlig A, Hesdorffer DC. SUDEP's health burden and when to talk about it. Epilepsia. 2014 Oct; 55(10):1477-8. PMID: 25323731.
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    43. Mathern G, Beninsig L, Nehlig A. From the editors: our paper (first) anniversary and launching Epilepsia's new look. Epilepsia. 2014 Jul; 55(7):949-55. PMID: 25040631.
      View in: PubMed
    44. Mathern G, Nehlig A. From the editors: using consciousness to describe seizures and classify the epilepsies. Epilepsia. 2014 Aug; 55(8):1139. PMID: 24981875.
      View in: PubMed
    45. Mathern G, Nehlig A. From the editors: the discrepancy between accumulative incidence and lifetime prevalence of epilepsy. Epilepsia. 2014 Jul; 55(7):956-7. PMID: 24964823.
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    46. Mathern G, Nehlig A, Sperling M. Cannabidiol and medical marijuana for the treatment of epilepsy. Epilepsia. 2014 Jun; 55(6):781-2. PMID: 24854631.
      View in: PubMed
    47. Mathern G, Nehlig A. From the editors: Introducing Epilepsia's Controversy in Epilepsy series. Epilepsia. 2014 May; 55(5):627-8. PMID: 24815723.
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    48. Fisher RS, Acevedo C, Arzimanoglou A, Bogacz A, Cross JH, Elger CE, Engel J, Forsgren L, French JA, Glynn M, Hesdorffer DC, Lee BI, Mathern G, Moshé SL, Perucca E, Scheffer IE, Tomson T, Watanabe M, Wiebe S. ILAE official report: a practical clinical definition of epilepsy. Epilepsia. 2014 Apr; 55(4):475-82. PMID: 24730690.
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    49. Lewis DV, Shinnar S, Hesdorffer DC, Bagiella E, Bello JA, Chan S, Xu Y, MacFall J, Gomes WA, Moshé SL, Mathern G, Pellock JM, Nordli DR, Frank LM, Provenzale J, Shinnar RC, Epstein LG, Masur D, Litherland C, Sun S. Hippocampal sclerosis after febrile status epilepticus: the FEBSTAT study. Ann Neurol. 2014 Feb; 75(2):178-85. PMID: 24318290; PMCID: PMC3980500.
    50. Rosenow F, Alonso-Vanegas MA, Baumgartner C, Blümcke I, Carreño M, Gizewski ER, Hamer HM, Knake S, Kahane P, Lüders HO, Mathern G, Menzler K, Miller J, Otsuki T, Ozkara C, Pitkänen A, Roper SN, Sakamoto AC, Sure U, Walker MC, Steinhoff BJ. In response to commentary on cavernoma-related epilepsy: review and recommendations for management-report of the surgical task force of the ILAE commission on therapeutic strategies. Epilepsia. 2014 Mar; 55(3):466-7. PMID: 24628654.
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    51. Mathern G, Nehlig A. Editorial: reducing stigma by changing the name of epilepsy. Epilepsia. 2014 Mar; 55(3):383. PMID: 24628652.
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    52. Jayakar P, Gaillard WD, Tripathi M, Libenson MH, Mathern G, Cross JH. Diagnostic test utilization in evaluation for resective epilepsy surgery in children. Epilepsia. 2014 Apr; 55(4):507-18. PMID: 24512473.
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    53. Varadkar S, Bien CG, Kruse CA, Jensen FE, Bauer J, Pardo CA, Vincent A, Mathern G, Cross JH. Rasmussen's encephalitis: clinical features, pathobiology, and treatment advances. Lancet Neurol. 2014 Feb; 13(2):195-205. PMID: 24457189; PMCID: PMC4005780.
    54. Rosenow F, Alonso-Vanegas MA, Baumgartner C, Blümcke I, Carreño M, Gizewski ER, Hamer HM, Knake S, Kahane P, Lüders HO, Mathern G, Menzler K, Miller J, Otsuki T, Ozkara C, Pitkänen A, Roper SN, Sakamoto AC, Sure U, Walker MC, Steinhoff BJ. Cavernoma-related epilepsy: review and recommendations for management--report of the Surgical Task Force of the ILAE Commission on Therapeutic Strategies. Epilepsia. 2013 Dec; 54(12):2025-35. PMID: 24134485.
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    55. Phung J, Krogstad P, Mathern G. Fevers and abnormal blood and cerebrospinal fluid studies after pediatric cerebral hemispherectomy: impact of etiology and age at surgery. J Neurosurg Pediatr. 2013 Dec; 12(6):595-603. PMID: 24116983.
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    56. Cepeda C, Chen JY, Wu JY, Fisher RS, Vinters HV, Mathern G, Levine MS. Pacemaker GABA synaptic activity may contribute to network synchronization in pediatric cortical dysplasia. Neurobiol Dis. 2014 Feb; 62:208-17. PMID: 24121115; PMCID: PMC3877734.
    57. Mathern G, Nehlig A. Epilepsia editorial: publications by country. Epilepsia. 2013 Nov; 54(11):1849-50. PMID: 24117379.
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    58. Phung J, Krogstad P, Mathern G. Etiology associated with developing posthemispherectomy hydrocephalus after resection-disconnection procedures. J Neurosurg Pediatr. 2013 Nov; 12(5):469-75. PMID: 24011367.
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    59. Mathern G, Nehlig A. Introduction of new Editors-in-Chief, Epilepsia. Epilepsia. 2013 Jul; 54(7):1141-2. PMID: 23815570.
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    60. Hauptman JS, Dadour A, Oh T, Baca CB, Vickrey BG, Vassar S, Sankar R, Salamon N, Vinters HV, Mathern G. Time to pediatric epilepsy surgery is longer and developmental outcomes lower for government compared with private insurance. Neurosurgery. 2013 Jul; 73(1):152-7. PMID: 23615092.
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    61. Akhtari M, Pope W, Mathern G, Moats R, Frew A, Mandelkern M. Functionalized magnetonanoparticles in visualization of intracranial tumors on MRI. Mol Imaging Biol. 2013 Jun; 15(3):299-306. PMID: 23184607.
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    62. Blümcke I, Thom M, Aronica E, Armstrong DD, Bartolomei F, Bernasconi A, Bernasconi N, Bien CG, Cendes F, Coras R, Cross JH, Jacques TS, Kahane P, Mathern G, Miyata H, Moshé SL, Oz B, Özkara Ç, Perucca E, Sisodiya S, Wiebe S, Spreafico R. International consensus classification of hippocampal sclerosis in temporal lobe epilepsy: a Task Force report from the ILAE Commission on Diagnostic Methods. Epilepsia. 2013 Jul; 54(7):1315-29. PMID: 23692496.
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    63. Sarafian TA, Ryan CM, Souda P, Masliah E, Kar UK, Vinters HV, Mathern G, Faull KF, Whitelegge JP, Watson JB. Impairment of mitochondria in adult mouse brain overexpressing predominantly full-length, N-terminally acetylated human a-synuclein. PLoS One. 2013; 8(5):e63557. PMID: 23667637.
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    64. Owens GC, Huynh MN, Chang JW, McArthur DL, Hickey MJ, Vinters HV, Mathern G, Kruse CA. Differential expression of interferon-? and chemokine genes distinguishes Rasmussen encephalitis from cortical dysplasia and provides evidence for an early Th1 immune response. J Neuroinflammation. 2013 May 02; 10:56. PMID: 23639073; PMCID: PMC3657540.
    65. Phung J, Mathern G, Krogstad P. Timing and predictors of fever and infection after craniotomy for epilepsy in children. Pediatr Infect Dis J. 2013 May; 32(5):450-9. PMID: 23348815; PMCID: PMC3717398.
    66. Mathern G, Miller JW. Outcomes for temporal lobe epilepsy operations may not be equal: a call for an RCT of ATL vs SAH. Neurology. 2013 Apr 30; 80(18):1630-1. PMID: 23553476.
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    67. Baek ST, Gibbs EM, Gleeson JG, Mathern G. Hemimegalencephaly, a paradigm for somatic postzygotic neurodevelopmental disorders. Curr Opin Neurol. 2013 Apr; 26(2):122-7. PMID: 23449172.
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    68. Baca CB, Vickrey BG, Vassar S, Hauptman JS, Dadour A, Oh T, Salamon N, Vinters HV, Sankar R, Mathern G. Time to pediatric epilepsy surgery is related to disease severity and nonclinical factors. Neurology. 2013 Mar 26; 80(13):1231-9. PMID: 23468549; PMCID: PMC3691779.
    69. Hauptman JS, Dadour A, Oh T, Baca CB, Vickrey BG, Vassar SD, Sankar R, Salamon N, Vinters HV, Mathern G. Sociodemographic changes over 25 years of pediatric epilepsy surgery at UCLA. J Neurosurg Pediatr. 2013 Mar; 11(3):250-5. PMID: 23331214; PMCID: PMC3832187.
    70. Hauptman JS, Pedram K, Sison CA, Sankar R, Salamon N, Vinters HV, Mathern G. Pediatric epilepsy surgery: long-term 5-year seizure remission and medication use. Neurosurgery. 2012 Nov; 71(5):985-93. PMID: 22895408.
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    71. Hauptman JS, Mathern G. Vagal nerve stimulation for pharmacoresistant epilepsy in children. Surg Neurol Int. 2012; 3(Suppl 4):S269-74. PMID: 23230532; PMCID: PMC3514916.
    72. Chang JW, Arnold MM, Rozenbaum A, Caputo A, Schweizer FE, Huynh M, Mathern G, Sarafian TA, Watson JB. Synaptoneurosome micromethod for fractionation of mouse and human brain, and primary neuronal cultures. J Neurosci Methods. 2012 Nov 15; 211(2):289-95. PMID: 23017979.
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    73. Hauptman JS, Mathern G. Surgical treatment of epilepsy associated with cortical dysplasia: 2012 update. Epilepsia. 2012 Sep; 53 Suppl 4:98-104. PMID: 22946727.
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    74. Langfitt JT, Mathern G. Web-based eight-question tool to determine epilepsy surgery evaluation: the future is here. Neurology. 2012 Sep 11; 79(11):1074-5. PMID: 22895595.
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    75. Hauptman JS, Salamon N, Mathern G. Neuroimaging in the definition and organization of the epilepsies: we're not there yet. Epilepsia. 2012 Jul; 53 Suppl 2:22-7. PMID: 22765501; PMCID: PMC3397398.
    76. Lee JH, Huynh M, Silhavy JL, Kim S, Dixon-Salazar T, Heiberg A, Scott E, Bafna V, Hill KJ, Collazo A, Funari V, Russ C, Gabriel SB, Mathern G, Gleeson JG. De novo somatic mutations in components of the PI3K-AKT3-mTOR pathway cause hemimegalencephaly. Nat Genet. 2012 Jun 24; 44(8):941-5. PMID: 22729223; PMCID: PMC4417942.
    77. Wagner AS, Yin NS, Tung S, Mathern G, Vinters HV. Intimal thickening of meningeal arteries after serial corticectomies for Rasmussen encephalitis. Hum Pathol. 2012 Aug; 43(8):1308-13. PMID: 22401768.
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    78. Hauptman JS, Mathern G. Epilepsy neurosurgery in children. Handb Clin Neurol. 2012; 108:881-95. PMID: 22939072.
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    79. Moshé SL, Perucca E, Wiebe S, Mathern G. The International League Against Epilepsy at the threshold of its second century: year 2. Epilepsia. 2012 Jan; 53(1):215-9. PMID: 22221160; PMCID: PMC3257820.
    80. de Bode S, Fritz S, Mathern G. Cerebral hemispherectomy: sensory scores before and after intensive mobility training. Brain Dev. 2012 Sep; 34(8):625-31. PMID: 22137579; PMCID: PMC3413311.
    81. Cepeda C, André VM, Hauptman JS, Yamazaki I, Huynh MN, Chang JW, Chen JY, Fisher RS, Vinters HV, Levine MS, Mathern G. Enhanced GABAergic network and receptor function in pediatric cortical dysplasia Type IIB compared with Tuberous Sclerosis Complex. Neurobiol Dis. 2012 Jan; 45(1):310-21. PMID: 21889982; PMCID: PMC3225687.
    82. Velasco TR, Wichert-Ana L, Mathern G, Araújo D, Walz R, Bianchin MM, Dalmagro CL, Leite JP, Santos AC, Assirati JA, Carlotti CG, Sakamoto AC. Utility of ictal single photon emission computed tomography in mesial temporal lobe epilepsy with hippocampal atrophy: a randomized trial. Neurosurgery. 2011 Feb; 68(2):431-6; discussion 436. PMID: 21135733.
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    83. Moshé SL, Perucca E, Wiebe S, Mathern G. The International League Against Epilepsy at the threshold of its second century: year 1. Epilepsia. 2011 Jan; 52(1):185-7. PMID: 21219305; PMCID: PMC3059223.
    84. Blümcke I, Thom M, Aronica E, Armstrong DD, Vinters HV, Palmini A, Jacques TS, Avanzini G, Barkovich AJ, Battaglia G, Becker A, Cepeda C, Cendes F, Colombo N, Crino P, Cross JH, Delalande O, Dubeau F, Duncan J, Guerrini R, Kahane P, Mathern G, Najm I, Ozkara C, Raybaud C, Represa A, Roper SN, Salamon N, Schulze-Bonhage A, Tassi L, Vezzani A, Spreafico R. The clinicopathologic spectrum of focal cortical dysplasias: a consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission. Epilepsia. 2011 Jan; 52(1):158-74. PMID: 21219302; PMCID: PMC3058866.
    85. Mathern G. Cerebral hemispherectomy: when half a brain is good enough. Neurology. 2010 Nov 02; 75(18):1578-80. PMID: 21041781.
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    86. Thom M, Mathern G, Cross JH, Bertram EH. Mesial temporal lobe epilepsy: How do we improve surgical outcome? Ann Neurol. 2010 Oct; 68(4):424-34. PMID: 20976764; PMCID: PMC2966035.
    87. Qin W, Chan JA, Vinters HV, Mathern G, Franz DN, Taillon BE, Bouffard P, Kwiatkowski DJ. Analysis of TSC cortical tubers by deep sequencing of TSC1, TSC2 and KRAS demonstrates that small second-hit mutations in these genes are rare events. Brain Pathol. 2010 Nov; 20(6):1096-105. PMID: 20633017; PMCID: PMC2951479.
    88. André VM, Cepeda C, Vinters HV, Huynh M, Mathern G, Levine MS. Interneurons, GABAA currents, and subunit composition of the GABAA receptor in type I and type II cortical dysplasia. Epilepsia. 2010 Jul; 51 Suppl 3:166-70. PMID: 20618425; PMCID: PMC2909022.
    89. Cepeda C, André VM, Yamazaki I, Hauptman JS, Chen JY, Vinters HV, Mathern G, Levine MS. Comparative study of cellular and synaptic abnormalities in brain tissue samples from pediatric tuberous sclerosis complex and cortical dysplasia type II. Epilepsia. 2010 Jul; 51 Suppl 3:160-5. PMID: 20618424; PMCID: PMC2909023.
    90. Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, Cross JH, van Emde Boas W, Engel J, French J, Glauser TA, Mathern G, Moshé SL, Nordli D, Plouin P, Scheffer IE. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia. 2010 Apr; 51(4):676-85. PMID: 20196795.
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    91. Mathern G. Commentary. Surg Neurol. 2009 Dec 01; 72(6):591. PMID: 20606717.
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    92. Kwan P, Arzimanoglou A, Berg AT, Brodie MJ, Allen Hauser W, Mathern G, Moshé SL, Perucca E, Wiebe S, French J. Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies. Epilepsia. 2010 Jun; 51(6):1069-77. PMID: 19889013.
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    93. Mathern G. Challenges in the surgical treatment of epilepsy patients with cortical dysplasia. Epilepsia. 2009 Oct; 50 Suppl 9:45-50. PMID: 19761453.
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    94. Mehta RI, Cutler AR, Lasky JL, Yong WH, Lerner JT, Hirota BK, Salamon N, Mathern G, Vinters HV. "Primary" leptomeningeal medulloblastoma. Hum Pathol. 2009 Nov; 40(11):1661-5. PMID: 19695677.
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    95. Berg AT, Mathern G, Bronen RA, Fulbright RK, DiMario F, Testa FM, Levy SR. Frequency, prognosis and surgical treatment of structural abnormalities seen with magnetic resonance imaging in childhood epilepsy. Brain. 2009 Oct; 132(Pt 10):2785-97. PMID: 19638447; PMCID: PMC2759335.
    96. Khanlou N, Mathern G, Mitchell WG, Salamon N, Pope WB, Yong WH, Vinters HV. Cortical dysplasia with prominent Rosenthal fiber formation in a case of intractable pediatric epilepsy. Hum Pathol. 2009 Aug; 40(8):1200-4. PMID: 19427021.
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    97. Wirenfeldt M, Clare R, Tung S, Bottini A, Mathern G, Vinters HV. Increased activation of Iba1+ microglia in pediatric epilepsy patients with Rasmussen's encephalitis compared with cortical dysplasia and tuberous sclerosis complex. Neurobiol Dis. 2009 Jun; 34(3):432-40. PMID: 19285133; PMCID: PMC2683191.
    98. de Bode S, Fritz SL, Weir-Haynes K, Mathern G. Constraint-induced movement therapy for individuals after cerebral hemispherectomy: a case series. Phys Ther. 2009 Apr; 89(4):361-9. PMID: 19246557; PMCID: PMC2664995.
    99. Lerner JT, Salamon N, Hauptman JS, Velasco TR, Hemb M, Wu JY, Sankar R, Donald Shields W, Engel J, Fried I, Cepeda C, Andre VM, Levine MS, Miyata H, Yong WH, Vinters HV, Mathern G. Assessment and surgical outcomes for mild type I and severe type II cortical dysplasia: a critical review and the UCLA experience. Epilepsia. 2009 Jun; 50(6):1310-35. PMID: 19175385.
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    100. Mathern G. Epilepsy surgery patients with cortical dysplasia: present and future therapeutic challenges. Neurology. 2009 Jan 20; 72(3):206-7. PMID: 19005172.
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    101. André VM, Cepeda C, Vinters HV, Huynh M, Mathern G, Levine MS. Pyramidal cell responses to gamma-aminobutyric acid differ in type I and type II cortical dysplasia. J Neurosci Res. 2008 Nov 01; 86(14):3151-62. PMID: 18615638.
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    102. Wu JY, Koh S, Sankar R, Mathern G. Paroxysmal fast activity: an interictal scalp EEG marker of epileptogenesis in children. Epilepsy Res. 2008 Nov; 82(1):99-106. PMID: 18804956; PMCID: PMC4830694.
    103. Harvey AS, Cross JH, Shinnar S, Mathern G, Mathern BW. Defining the spectrum of international practice in pediatric epilepsy surgery patients. Epilepsia. 2008 Jan; 49(1):146-55. PMID: 18042232.
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    104. Staba RJ, Frighetto L, Behnke EJ, Mathern G, Fields T, Bragin A, Ogren J, Fried I, Wilson CL, Engel J. Increased fast ripple to ripple ratios correlate with reduced hippocampal volumes and neuron loss in temporal lobe epilepsy patients. Epilepsia. 2007 Nov; 48(11):2130-8. PMID: 17662059.
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    105. André VM, Wu N, Yamazaki I, Nguyen ST, Fisher RS, Vinters HV, Mathern G, Levine MS, Cepeda C. Cytomegalic interneurons: a new abnormal cell type in severe pediatric cortical dysplasia. J Neuropathol Exp Neurol. 2007 Jun; 66(6):491-504. PMID: 17549009.
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    106. de Bode S, Sininger Y, Healy EW, Mathern G, Zaidel E. Dichotic listening after cerebral hemispherectomy: methodological and theoretical observations. Neuropsychologia. 2007 Jun 18; 45(11):2461-6. PMID: 17512023; PMCID: PMC1948872.
    107. de Bode S, Mathern G, Bookheimer S, Dobkin B. Locomotor training remodels fMRI sensorimotor cortical activations in children after cerebral hemispherectomy. Neurorehabil Neural Repair. 2007 Nov-Dec; 21(6):497-508. PMID: 17369509; PMCID: PMC4080925.
    108. Cepeda C, André VM, Wu N, Yamazaki I, Uzgil B, Vinters HV, Levine MS, Mathern G. Immature neurons and GABA networks may contribute to epileptogenesis in pediatric cortical dysplasia. Epilepsia. 2007; 48 Suppl 5:79-85. PMID: 17910585.
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    109. Mathern G, Andres M, Salamon N, Chandra PS, Andre VM, Cepeda C, Levine MS, Leite JP, Neder L, Vinters HV. A hypothesis regarding the pathogenesis and epileptogenesis of pediatric cortical dysplasia and hemimegalencephaly based on MRI cerebral volumes and NeuN cortical cell densities. Epilepsia. 2007; 48 Suppl 5:74-8. PMID: 17910584.
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    110. Mathern G, Trevathan E. Childhood-onset temporal lobe epilepsy: neuroimaging predicts seizure control. Neurology. 2006 Dec 26; 67(12):2117-8. PMID: 17190930.
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    111. Huang SY, Wolahan SM, Mathern G, Chute DJ, Akhtari M, Nguyen ST, Huynh MN, Salamon N, Lin YY. Improving MRI differentiation of gray and white matter in epileptogenic lesions based on nonlinear feedback. Magn Reson Med. 2006 Oct; 56(4):776-86. PMID: 16941616.
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    112. Chandra PS, Salamon N, Huang J, Wu JY, Koh S, Vinters HV, Mathern G. FDG-PET/MRI coregistration and diffusion-tensor imaging distinguish epileptogenic tubers and cortex in patients with tuberous sclerosis complex: a preliminary report. Epilepsia. 2006 Sep; 47(9):1543-9. PMID: 16981871.
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    113. Cepeda C, André VM, Levine MS, Salamon N, Miyata H, Vinters HV, Mathern G. Epileptogenesis in pediatric cortical dysplasia: the dysmature cerebral developmental hypothesis. Epilepsy Behav. 2006 Sep; 9(2):219-35. PMID: 16875879.
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    114. Cross JH, Jayakar P, Nordli D, Delalande O, Duchowny M, Wieser HG, Guerrini R, Mathern G. Proposed criteria for referral and evaluation of children for epilepsy surgery: recommendations of the Subcommission for Pediatric Epilepsy Surgery. Epilepsia. 2006 Jun; 47(6):952-9. PMID: 16822241.
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    115. Leppik IE, Kelly KM, deToledo-Morrell L, Patrylo PR, DeLorenzo RJ, Mathern G, White HS. Basic research in epilepsy and aging. Epilepsy Res. 2006 Jan; 68 Suppl 1:S21-37. PMID: 16384687.
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    116. Koh S, Mathern G, Glasser G, Wu JY, Shields WD, Jonas R, Yudovin S, Cepeda C, Salamon N, Vinters HV, Sankar R. Status epilepticus and frequent seizures: incidence and clinical characteristics in pediatric epilepsy surgery patients. Epilepsia. 2005 Dec; 46(12):1950-4. PMID: 16393161.
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    117. Salamon N, Andres M, Chute DJ, Nguyen ST, Chang JW, Huynh MN, Chandra PS, Andre VM, Cepeda C, Levine MS, Leite JP, Neder L, Vinters HV, Mathern G. Contralateral hemimicrencephaly and clinical-pathological correlations in children with hemimegalencephaly. Brain. 2006 Feb; 129(Pt 2):352-65. PMID: 16291806.
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    118. Cepeda C, André VM, Vinters HV, Levine MS, Mathern G. Are cytomegalic neurons and balloon cells generators of epileptic activity in pediatric cortical dysplasia? Epilepsia. 2005; 46 Suppl 5:82-8. PMID: 15987258.
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    119. de Bode S, Firestine A, Mathern G, Dobkin B. Residual motor control and cortical representations of function following hemispherectomy: effects of etiology. J Child Neurol. 2005 Jan; 20(1):64-75. PMID: 15791926.
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    120. Andres M, Andre VM, Nguyen S, Salamon N, Cepeda C, Levine MS, Leite JP, Neder L, Vinters HV, Mathern G. Human cortical dysplasia and epilepsy: an ontogenetic hypothesis based on volumetric MRI and NeuN neuronal density and size measurements. Cereb Cortex. 2005 Feb; 15(2):194-210. PMID: 15297365.
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    121. Koh S, Nguyen S, Asarnow RF, LoPresti C, Yudovin S, Shields WD, Vinters HV, Mathern G. Five or more acute postoperative seizures predict hospital course and long-term seizure control after hemispherectomy. Epilepsia. 2004 May; 45(5):527-33. PMID: 15101834.
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    122. André VM, Flores-Hernández J, Cepeda C, Starling AJ, Nguyen S, Lobo MK, Vinters HV, Levine MS, Mathern G. NMDA receptor alterations in neurons from pediatric cortical dysplasia tissue. Cereb Cortex. 2004 Jun; 14(6):634-46. PMID: 15054078.
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    123. Cook SW, Nguyen ST, Hu B, Yudovin S, Shields WD, Vinters HV, Van de Wiele BM, Harrison RE, Mathern G. Cerebral hemispherectomy in pediatric patients with epilepsy: comparison of three techniques by pathological substrate in 115 patients. J Neurosurg. 2004 Feb; 100(2 Suppl Pediatrics):125-41. PMID: 14758940.
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    124. Stables JP, Bertram E, Dudek FE, Holmes G, Mathern G, Pitkanen A, White HS. Therapy discovery for pharmacoresistant epilepsy and for disease-modifying therapeutics: summary of the NIH/NINDS/AES models II workshop. Epilepsia. 2003 Dec; 44(12):1472-8. PMID: 14636315.
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    125. Bender RA, Soleymani SV, Brewster AL, Nguyen ST, Beck H, Mathern G, Baram TZ. Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus. J Neurosci. 2003 Jul 30; 23(17):6826-36. PMID: 12890777; PMCID: PMC3100807.
    126. Cepeda C, Hurst RS, Flores-Hernández J, Hernández-Echeagaray E, Klapstein GJ, Boylan MK, Calvert CR, Jocoy EL, Nguyen OK, André VM, Vinters HV, Ariano MA, Levine MS, Mathern G. Morphological and electrophysiological characterization of abnormal cell types in pediatric cortical dysplasia. J Neurosci Res. 2003 May 15; 72(4):472-86. PMID: 12704809.
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    127. Shusta EV, Boado RJ, Mathern G, Pardridge WM. Vascular genomics of the human brain. J Cereb Blood Flow Metab. 2002 Mar; 22(3):245-52. PMID: 11891429.
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    128. Mathern G, Leiphart JL, De Vera A, Adelson PD, Seki T, Neder L, Leite JP. Seizures decrease postnatal neurogenesis and granule cell development in the human fascia dentata. Epilepsia. 2002; 43 Suppl 5:68-73. PMID: 12121298.
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    129. Mathern G, Adelson PD, Cahan LD, Leite JP. Hippocampal neuron damage in human epilepsy: Meyer's hypothesis revisited. Prog Brain Res. 2002; 135:237-51. PMID: 12143344.
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    130. Caplan R, Siddarth P, Mathern G, Vinters H, Curtiss S, Levitt J, Asarnow R, Shields WD. Developmental outcome with and without successful intervention. Int Rev Neurobiol. 2002; 49:269-84. PMID: 12040897.
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    131. Mathern G, Cepeda C, Hurst RS, Flores-Hernandez J, Mendoza D, Levine MS. Neurons recorded from pediatric epilepsy surgery patients with cortical dysplasia. Epilepsia. 2000; 41 Suppl 6:S162-7. PMID: 10999538.
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    132. Mathern G, Giza CC, Yudovin S, Vinters HV, Peacock WJ, Shewmon DA, Shields WD. Postoperative seizure control and antiepileptic drug use in pediatric epilepsy surgery patients: the UCLA experience, 1986-1997. Epilepsia. 1999 Dec; 40(12):1740-9. PMID: 10612338.
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    133. Mathern G, Mendoza D, Lozada A, Pretorius JK, Dehnes Y, Danbolt NC, Nelson N, Leite JP, Chimelli L, Born DE, Sakamoto AC, Assirati JA, Fried I, Peacock WJ, Ojemann GA, Adelson PD. Hippocampal GABA and glutamate transporter immunoreactivity in patients with temporal lobe epilepsy. Neurology. 1999 Feb; 52(3):453-72. PMID: 10025773.
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    134. Mathern G, Pretorius JK, Mendoza D, Lozada A, Kornblum HI. Hippocampal AMPA and NMDA mRNA levels correlate with aberrant fascia dentata mossy fiber sprouting in the pilocarpine model of spontaneous limbic epilepsy. J Neurosci Res. 1998 Dec 15; 54(6):734-53. PMID: 9856858.
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    135. Mathern G, Pretorius JK, Leite JP, Kornblum HI, Mendoza D, Lozada A, Bertram EH. Hippocampal AMPA and NMDA mRNA levels and subunit immunoreactivity in human temporal lobe epilepsy patients and a rodent model of chronic mesial limbic epilepsy. Epilepsy Res. 1998 Sep; 32(1-2):154-71. PMID: 9761317.
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    136. Mathern G, Price G, Rosales C, Pretorius JK, Lozada A, Mendoza D. Anoxia during kainate status epilepticus shortens behavioral convulsions but generates hippocampal neuron loss and supragranular mossy fiber sprouting. Epilepsy Res. 1998 Apr; 30(2):133-51. PMID: 9600545.
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    137. Mathern G, Babb TL, Leite JP, Pretorius K, Yeoman KM, Kuhlman PA. The pathogenic and progressive features of chronic human hippocampal epilepsy. Epilepsy Res. 1996 Dec; 26(1):151-61. PMID: 8985697.
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