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Kaback H.

TitleDistinguished Professor
InstitutionUniversity of California Los Angeles
DepartmentPhysiology
AddressMRL
Los Angeles CA 90095
Phone(310) 206-5055
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    TitleProfessor


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Kumar H, Finer-Moore JS, Jiang X, Smirnova I, Kasho V, Pardon E, Steyaert J, Kaback HR, Stroud RM. Crystal Structure of a ligand-bound LacY-Nanobody Complex. Proc Natl Acad Sci U S A. 2018 Aug 14. PMID: 30108145.
      View in: PubMed
    2. Smirnova I, Kasho V, Jiang X, Chen HM, Withers SG, Kaback HR. Oversized galactosides as a probe for conformational dynamics in LacY. Proc Natl Acad Sci U S A. 2018 Apr 17; 115(16):4146-4151. PMID: 29602806.
      View in: PubMed
    3. Smirnova I, Kasho V, Jiang X, Kaback HR. An Asymmetric Conformational Change in LacY. Biochemistry. 2017 04 04; 56(13):1943-1950. PMID: 28300394.
      View in: PubMed
    4. Grytsyk N, Sugihara J, Kaback HR, Hellwig P. pKa of Glu325 in LacY. Proc Natl Acad Sci U S A. 2017 02 14; 114(7):1530-1535. PMID: 28154138.
      View in: PubMed
    5. Jiang X, Smirnova I, Kasho V, Wu J, Hirata K, Ke M, Pardon E, Steyaert J, Yan N, Kaback HR. Crystal structure of a LacY-nanobody complex in a periplasmic-open conformation. Proc Natl Acad Sci U S A. 2016 11 01; 113(44):12420-12425. PMID: 27791182.
      View in: PubMed
    6. Serdiuk T, Balasubramaniam D, Sugihara J, Mari SA, Kaback HR, Müller DJ. YidC assists the stepwise and stochastic folding of membrane proteins. Nat Chem Biol. 2016 Nov; 12(11):911-917. PMID: 27595331.
      View in: PubMed
    7. Jiang X, Andersson M, Chau BT, Wong LY, Villafuerte MK, Kaback HR. Role of Conserved Gly-Gly Pairs on the Periplasmic Side of LacY. Biochemistry. 2016 08 09; 55(31):4326-32. PMID: 27438891.
      View in: PubMed
    8. Smirnova I, Kasho V, Jiang X, Pardon E, Steyaert J, Kaback HR. Transient conformers of LacY are trapped by nanobodies. Proc Natl Acad Sci U S A. 2015 Nov 10; 112(45):13839-44. PMID: 26512108; PMCID: PMC4653160.
    9. Kumar H, Finer-Moore JS, Kaback HR, Stroud RM. Structure of LacY with an a-substituted galactoside: Connecting the binding site to the protonation site. Proc Natl Acad Sci U S A. 2015 Jul 21; 112(29):9004-9. PMID: 26157133; PMCID: PMC4517220.
    10. Serdiuk T, Sugihara J, Mari SA, Kaback HR, Müller DJ. Observing a lipid-dependent alteration in single lactose permeases. Structure. 2015 Apr 07; 23(4):754-61. PMID: 25800555; PMCID: PMC4394043.
    11. Hariharan P, Balasubramaniam D, Peterkofsky A, Kaback HR, Guan L. Thermodynamic mechanism for inhibition of lactose permease by the phosphotransferase protein IIAGlc. Proc Natl Acad Sci U S A. 2015 Feb 24; 112(8):2407-12. PMID: 25675534; PMCID: PMC4345578.
    12. Kaback HR. A chemiosmotic mechanism of symport. Proc Natl Acad Sci U S A. 2015 Feb 03; 112(5):1259-64. PMID: 25568085; PMCID: PMC4321259.
    13. Smirnova I, Kasho V, Jiang X, Pardon E, Steyaert J, Kaback HR. Outward-facing conformers of LacY stabilized by nanobodies. Proc Natl Acad Sci U S A. 2014 Dec 30; 111(52):18548-53. PMID: 25512549; PMCID: PMC4284591.
    14. Smirnova I, Kasho V, Kaback HR. Real-time conformational changes in LacY. Proc Natl Acad Sci U S A. 2014 Jun 10; 111(23):8440-5. PMID: 24872451; PMCID: PMC4060661.
    15. Serdiuk T, Madej MG, Sugihara J, Kawamura S, Mari SA, Kaback HR, Müller DJ. Substrate-induced changes in the structural properties of LacY. Proc Natl Acad Sci U S A. 2014 Apr 22; 111(16):E1571-80. PMID: 24711390; PMCID: PMC4000801.
    16. Jiang X, Villafuerte MK, Andersson M, White SH, Kaback HR. Galactoside-binding site in LacY. Biochemistry. 2014 Mar 11; 53(9):1536-43. PMID: 24520888; PMCID: PMC3985706.
    17. Madej MG, Sun L, Yan N, Kaback HR. Functional architecture of MFS D-glucose transporters. Proc Natl Acad Sci U S A. 2014 Feb 18; 111(7):E719-27. PMID: 24550316; PMCID: PMC3932877.
    18. Kumar H, Kasho V, Smirnova I, Finer-Moore JS, Kaback HR, Stroud RM. Structure of sugar-bound LacY. Proc Natl Acad Sci U S A. 2014 Feb 04; 111(5):1784-8. PMID: 24453216; PMCID: PMC3918835.
    19. Ethayathulla AS, Yousef MS, Amin A, Leblanc G, Kaback HR, Guan L. Structure-based mechanism for Na(+)/melibiose symport by MelB. Nat Commun. 2014; 5:3009. PMID: 24389923; PMCID: PMC4026327.
    20. Madej MG, Kaback HR. Evolutionary mix-and-match with MFS transporters II. Proc Natl Acad Sci U S A. 2013 Dec 10; 110(50):E4831-8. PMID: 24259711; PMCID: PMC3864288.
    21. Gaiko O, Bazzone A, Fendler K, Kaback HR. Electrophysiological characterization of uncoupled mutants of LacY. Biochemistry. 2013 Nov 19; 52(46):8261-6. PMID: 24152072.
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    22. Jiang X, Driessen AJ, Feringa BL, Kaback HR. The periplasmic cavity of LacY mutant Cys154?Gly: how open is open? Biochemistry. 2013 Sep 17; 52(37):6568-74. PMID: 23962108; PMCID: PMC3951333.
    23. Zhu L, Kaback HR, Dalbey RE. YidC protein, a molecular chaperone for LacY protein folding via the SecYEG protein machinery. J Biol Chem. 2013 Sep 27; 288(39):28180-94. PMID: 23928306; PMCID: PMC3784728.
    24. Smirnova I, Kasho V, Sugihara J, Kaback HR. Trp replacements for tightly interacting Gly-Gly pairs in LacY stabilize an outward-facing conformation. Proc Natl Acad Sci U S A. 2013 May 28; 110(22):8876-81. PMID: 23671103; PMCID: PMC3670396.
    25. Madej MG, Dang S, Yan N, Kaback HR. Evolutionary mix-and-match with MFS transporters. Proc Natl Acad Sci U S A. 2013 Apr 09; 110(15):5870-4. PMID: 23530251; PMCID: PMC3625355.
    26. Smirnova I, Kasho V, Sugihara J, Vázquez-Ibar JL, Kaback HR. Role of protons in sugar binding to LacY. Proc Natl Acad Sci U S A. 2012 Oct 16; 109(42):16835-40. PMID: 23033496; PMCID: PMC3479522.
    27. Madej MG, Soro SN, Kaback HR. Apo-intermediate in the transport cycle of lactose permease (LacY). Proc Natl Acad Sci U S A. 2012 Oct 30; 109(44):E2970-8. PMID: 23012238; PMCID: PMC3497813.
    28. Andersson M, Bondar AN, Freites JA, Tobias DJ, Kaback HR, White SH. Proton-coupled dynamics in lactose permease. Structure. 2012 Nov 07; 20(11):1893-904. PMID: 23000385; PMCID: PMC3496080.
    29. Sugihara J, Sun L, Yan N, Kaback HR. Dynamics of the L-fucose/H+ symporter revealed by fluorescence spectroscopy. Proc Natl Acad Sci U S A. 2012 Sep 11; 109(37):14847-51. PMID: 22930818; PMCID: PMC3443143.
    30. Zhou Y, Jiang X, Kaback HR. Role of the irreplaceable residues in the LacY alternating access mechanism. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12438-42. PMID: 22802658; PMCID: PMC3412042.
    31. Jiang X, Guan L, Zhou Y, Hong WX, Zhang Q, Kaback HR. Evidence for an intermediate conformational state of LacY. Proc Natl Acad Sci U S A. 2012 Mar 20; 109(12):E698-704. PMID: 22355148; PMCID: PMC3311394.
    32. Sugihara J, Smirnova I, Kasho V, Kaback HR. Sugar recognition by CscB and LacY. Biochemistry. 2011 Dec 27; 50(51):11009-14. PMID: 22106930; PMCID: PMC3249425.
    33. Smirnova I, Kasho V, Kaback HR. Lactose permease and the alternating access mechanism. Biochemistry. 2011 Nov 15; 50(45):9684-93. PMID: 21995338; PMCID: PMC3210931.
    34. Smirnova I, Kasho V, Sugihara J, Kaback HR. Opening the periplasmic cavity in lactose permease is the limiting step for sugar binding. Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37):15147-51. PMID: 21896727; PMCID: PMC3174601.
    35. Zhou Y, Madej MG, Guan L, Nie Y, Kaback HR. An early event in the transport mechanism of LacY protein: interaction between helices V and I. J Biol Chem. 2011 Sep 02; 286(35):30415-22. PMID: 21730060; PMCID: PMC3162401.
    36. Chaptal V, Kwon S, Sawaya MR, Guan L, Kaback HR, Abramson J. Crystal structure of lactose permease in complex with an affinity inactivator yields unique insight into sugar recognition. Proc Natl Acad Sci U S A. 2011 Jun 07; 108(23):9361-6. PMID: 21593407; PMCID: PMC3111295.
    37. Jiang X, Nie Y, Kaback HR. Site-directed alkylation studies with LacY provide evidence for the alternating access model of transport. Biochemistry. 2011 Mar 15; 50(10):1634-40. PMID: 21254783; PMCID: PMC3057939.
    38. Kaback HR, Smirnova I, Kasho V, Nie Y, Zhou Y. The alternating access transport mechanism in LacY. J Membr Biol. 2011 Jan; 239(1-2):85-93. PMID: 21161516; PMCID: PMC3030946.
    39. Garcia-Celma JJ, Ploch J, Smirnova I, Kaback HR, Fendler K. Delineating electrogenic reactions during lactose/H+ symport. Biochemistry. 2010 Jul 27; 49(29):6115-21. PMID: 20568736; PMCID: PMC2907097.
    40. Nie Y, Kaback HR. Sugar binding induces the same global conformational change in purified LacY as in the native bacterial membrane. Proc Natl Acad Sci U S A. 2010 May 25; 107(21):9903-8. PMID: 20457922; PMCID: PMC2906848.
    41. Liu Z, Madej MG, Kaback HR. Helix dynamics in LacY: helices II and IV. J Mol Biol. 2010 Feb 26; 396(3):617-26. PMID: 20043916; PMCID: PMC3043081.
    42. Smirnova I, Kasho V, Sugihara J, Kaback HR. Probing of the rates of alternating access in LacY with Trp fluorescence. Proc Natl Acad Sci U S A. 2009 Dec 22; 106(51):21561-6. PMID: 19959662; PMCID: PMC2799877.
    43. Guan L, Kaback HR. Properties of a LacY efflux mutant. Biochemistry. 2009 Oct 06; 48(39):9250-5. PMID: 19719233; PMCID: PMC2754601.
    44. Zhou Y, Nie Y, Kaback HR. Residues gating the periplasmic pathway of LacY. J Mol Biol. 2009 Nov 27; 394(2):219-25. PMID: 19781551; PMCID: PMC2784193.
    45. Smirnova I, Kasho V, Sugihara J, Choe JY, Kaback HR. Residues in the H+ translocation site define the pKa for sugar binding to LacY. Biochemistry. 2009 Sep 22; 48(37):8852-60. PMID: 19689129; PMCID: PMC2769999.
    46. Garcia-Celma JJ, Smirnova IN, Kaback HR, Fendler K. Electrophysiological characterization of LacY. Proc Natl Acad Sci U S A. 2009 May 05; 106(18):7373-8. PMID: 19383792; PMCID: PMC2671326.
    47. Nie Y, Zhou Y, Kaback HR. Clogging the periplasmic pathway in LacY. Biochemistry. 2009 Feb 03; 48(4):738-43. PMID: 19128028; PMCID: PMC2654236.
    48. Smirnova IN, Kasho V, Kaback HR. Protonation and sugar binding to LacY. Proc Natl Acad Sci U S A. 2008 Jul 01; 105(26):8896-901. PMID: 18567672; PMCID: PMC3021437.
    49. Nie Y, Sabetfard FE, Kaback HR. The Cys154-->Gly mutation in LacY causes constitutive opening of the hydrophilic periplasmic pathway. J Mol Biol. 2008 Jun 13; 379(4):695-703. PMID: 18485365; PMCID: PMC2769995.
    50. Zhou Y, Guan L, Freites JA, Kaback HR. Opening and closing of the periplasmic gate in lactose permease. Proc Natl Acad Sci U S A. 2008 Mar 11; 105(10):3774-8. PMID: 18319336; PMCID: PMC2268789.
    51. Smirnova I, Kasho V, Choe JY, Altenbach C, Hubbell WL, Kaback HR. Sugar binding induces an outward facing conformation of LacY. Proc Natl Acad Sci U S A. 2007 Oct 16; 104(42):16504-9. PMID: 17925435; PMCID: PMC2034228.
    52. Guan L, Mirza O, Verner G, Iwata S, Kaback HR. Structural determination of wild-type lactose permease. Proc Natl Acad Sci U S A. 2007 Sep 25; 104(39):15294-8. PMID: 17881559; PMCID: PMC2000551.
    53. Nie Y, Ermolova N, Kaback HR. Site-directed alkylation of LacY: effect of the proton electrochemical gradient. J Mol Biol. 2007 Nov 23; 374(2):356-64. PMID: 17920075; PMCID: PMC2224895.
    54. Majumdar DS, Smirnova I, Kasho V, Nir E, Kong X, Weiss S, Kaback HR. Single-molecule FRET reveals sugar-induced conformational dynamics in LacY. Proc Natl Acad Sci U S A. 2007 Jul 31; 104(31):12640-5. PMID: 17502603; PMCID: PMC1937519.
    55. Guan L, Kaback HR. Site-directed alkylation of cysteine to test solvent accessibility of membrane proteins. Nat Protoc. 2007; 2(8):2012-7. PMID: 17703213; PMCID: PMC2775809.
    56. Kaback HR, Dunten R, Frillingos S, Venkatesan P, Kwaw I, Zhang W, Ermolova N. Site-directed alkylation and the alternating access model for LacY. Proc Natl Acad Sci U S A. 2007 Jan 09; 104(2):491-4. PMID: 17172438; PMCID: PMC1766412.
    57. Smirnova IN, Kasho VN, Kaback HR. Direct sugar binding to LacY measured by resonance energy transfer. Biochemistry. 2006 Dec 26; 45(51):15279-87. PMID: 17176050; PMCID: PMC2566955.
    58. Nie Y, Smirnova I, Kasho V, Kaback HR. Energetics of ligand-induced conformational flexibility in the lactose permease of Escherichia coli. J Biol Chem. 2006 Nov 24; 281(47):35779-84. PMID: 17003033; PMCID: PMC2793331.
    59. Ermolova N, Madhvani RV, Kaback HR. Site-directed alkylation of cysteine replacements in the lactose permease of Escherichia coli: helices I, III, VI, and XI. Biochemistry. 2006 Apr 04; 45(13):4182-9. PMID: 16566592.
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    60. Kasho VN, Smirnova IN, Kaback HR. Sequence alignment and homology threading reveals prokaryotic and eukaryotic proteins similar to lactose permease. J Mol Biol. 2006 May 12; 358(4):1060-70. PMID: 16574153; PMCID: PMC2785551.
    61. Vadyvaloo V, Smirnova IN, Kasho VN, Kaback HR. Conservation of residues involved in sugar/H(+) symport by the sucrose permease of Escherichia coli relative to lactose permease. J Mol Biol. 2006 May 12; 358(4):1051-9. PMID: 16574149; PMCID: PMC2786776.
    62. Mirza O, Guan L, Verner G, Iwata S, Kaback HR. Structural evidence for induced fit and a mechanism for sugar/H+ symport in LacY. EMBO J. 2006 Mar 22; 25(6):1177-83. PMID: 16525509; PMCID: PMC1422171.
    63. Guan L, Smirnova IN, Verner G, Nagamori S, Nagamoni S, Kaback HR. Manipulating phospholipids for crystallization of a membrane transport protein. Proc Natl Acad Sci U S A. 2006 Feb 07; 103(6):1723-6. PMID: 16446422; PMCID: PMC1413674.
    64. Guan L, Kaback HR. Lessons from lactose permease. Annu Rev Biophys Biomol Struct. 2006; 35:67-91. PMID: 16689628; PMCID: PMC2802108.
    65. Kaback HR. Structure and mechanism of the lactose permease. C R Biol. 2005 Jun; 328(6):557-67. PMID: 15950162.
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    66. Ermolova NV, Smirnova IN, Kasho VN, Kaback HR. Interhelical packing modulates conformational flexibility in the lactose permease of Escherichia coli. Biochemistry. 2005 May 31; 44(21):7669-77. PMID: 15909981.
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    67. Weinglass AB, Soskine M, Vazquez-Ibar JL, Whitelegge JP, Faull KF, Kaback HR, Schuldiner S. Exploring the role of a unique carboxyl residue in EmrE by mass spectrometry. J Biol Chem. 2005 Mar 04; 280(9):7487-92. PMID: 15623511.
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    68. Vázquez-Ibar JL, Guan L, Weinglass AB, Verner G, Gordillo R, Kaback HR. Sugar recognition by the lactose permease of Escherichia coli. J Biol Chem. 2004 Nov 19; 279(47):49214-21. PMID: 15364943.
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    69. Weinglass AB, Whitelegge JP, Kaback HR. Integrating mass spectrometry into membrane protein drug discovery. Curr Opin Drug Discov Devel. 2004 Sep; 7(5):589-99. PMID: 15503862.
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    70. Guan L, Kaback HR. Binding affinity of lactose permease is not altered by the H+ electrochemical gradient. Proc Natl Acad Sci U S A. 2004 Aug 17; 101(33):12148-52. PMID: 15304639; PMCID: PMC514448.
    71. Abramson J, Kaback HR, Iwata S. Structural comparison of lactose permease and the glycerol-3-phosphate antiporter: members of the major facilitator superfamily. Curr Opin Struct Biol. 2004 Aug; 14(4):413-9. PMID: 15313234.
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    72. Weinglass A, Whitelegge JP, Faull KF, Kaback HR. Monitoring conformational rearrangements in the substrate-binding site of a membrane transport protein by mass spectrometry. J Biol Chem. 2004 Oct 01; 279(40):41858-65. PMID: 15272008.
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    73. Abramson J, Iwata S, Kaback HR. Lactose permease as a paradigm for membrane transport proteins (Review). Mol Membr Biol. 2004 Jul-Aug; 21(4):227-36. PMID: 15371012.
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    74. Nagamori S, Smirnova IN, Kaback HR. Role of YidC in folding of polytopic membrane proteins. J Cell Biol. 2004 Apr; 165(1):53-62. PMID: 15067017; PMCID: PMC2172087.
    75. Abramson J, Smirnova I, Kasho V, Verner G, Iwata S, Kaback HR. The lactose permease of Escherichia coli: overall structure, the sugar-binding site and the alternating access model for transport. FEBS Lett. 2003 Nov 27; 555(1):96-101. PMID: 14630326.
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    76. Vázquez-Ibar JL, Guan L, Svrakic M, Kaback HR. Exploiting luminescence spectroscopy to elucidate the interaction between sugar and a tryptophan residue in the lactose permease of Escherichia coli. Proc Natl Acad Sci U S A. 2003 Oct 28; 100(22):12706-11. PMID: 14566061; PMCID: PMC240682.
    77. Ermolova N, Guan L, Kaback HR. Intermolecular thiol cross-linking via loops in the lactose permease of Escherichia coli. Proc Natl Acad Sci U S A. 2003 Sep 02; 100(18):10187-92. PMID: 12934015; PMCID: PMC193537.
    78. Sondej M, Vázquez-Ibar JL, Farshidi A, Peterkofsky A, Kaback HR. Characterization of a lactose permease mutant that binds IIAGlc in the absence of ligand. Biochemistry. 2003 Aug 05; 42(30):9153-9. PMID: 12885249.
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    79. Abramson J, Smirnova I, Kasho V, Verner G, Kaback HR, Iwata S. Structure and mechanism of the lactose permease of Escherichia coli. Science. 2003 Aug 01; 301(5633):610-5. PMID: 12893935.
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    80. Zhang W, Hu Y, Kaback HR. Site-directed sulfhydryl labeling of helix IX in the lactose permease of Escherichia coli. Biochemistry. 2003 May 06; 42(17):4904-8. PMID: 12718531.
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    81. Weinglass AB, Whitelegge JP, Hu Y, Verner GE, Faull KF, Kaback HR. Elucidation of substrate binding interactions in a membrane transport protein by mass spectrometry. EMBO J. 2003 Apr 01; 22(7):1467-77. PMID: 12660154; PMCID: PMC152890.
    82. Smirnova IN, Kaback HR. A mutation in the lactose permease of Escherichia coli that decreases conformational flexibility and increases protein stability. Biochemistry. 2003 Mar 18; 42(10):3025-31. PMID: 12627968.
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    83. Guan L, Hu Y, Kaback HR. Aromatic stacking in the sugar binding site of the lactose permease. Biochemistry. 2003 Feb 18; 42(6):1377-82. PMID: 12578349.
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    84. Nagamori S, Vázquez-Ibar JL, Weinglass AB, Kaback HR. In vitro synthesis of lactose permease to probe the mechanism of membrane insertion and folding. J Biol Chem. 2003 Apr 25; 278(17):14820-6. PMID: 12590141.
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    85. Guan L, Sahin-Tóth M, Kálai T, Hideg K, Kaback HR. Probing the mechanism of a membrane transport protein with affinity inactivators. J Biol Chem. 2003 Mar 21; 278(12):10641-8. PMID: 12471022.
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    86. Sahin-Tóth M, Gunawan P, Lawrence MC, Toyokuni T, Kaback HR. Binding of hydrophobic D-galactopyranosides to the lactose permease of Escherichia coli. Biochemistry. 2002 Oct 29; 41(43):13039-45. PMID: 12390031.
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    87. Sorgen PL, Hu Y, Guan L, Kaback HR, Girvin ME. An approach to membrane protein structure without crystals. Proc Natl Acad Sci U S A. 2002 Oct 29; 99(22):14037-40. PMID: 12391320; PMCID: PMC137832.
    88. Guan L, Sahin-Toth M, Kaback HR. Changing the lactose permease of Escherichia coli into a galactose-specific symporter. Proc Natl Acad Sci U S A. 2002 May 14; 99(10):6613-8. PMID: 12011425; PMCID: PMC124451.
    89. Sondej M, Weinglass AB, Peterkofsky A, Kaback HR. Binding of enzyme IIAGlc, a component of the phosphoenolpyruvate:sugar phosphotransferase system, to the Escherichia coli lactose permease. Biochemistry. 2002 Apr 30; 41(17):5556-65. PMID: 11969416.
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    90. Guan L, Murphy FD, Kaback HR. Surface-exposed positions in the transmembrane helices of the lactose permease of Escherichia coli determined by intermolecular thiol cross-linking. Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):3475-80. PMID: 11904412; PMCID: PMC122548.
    91. Vázquez-Ibar JL, Weinglass AB, Kaback HR. Engineering a terbium-binding site into an integral membrane protein for luminescence energy transfer. Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):3487-92. PMID: 11891311; PMCID: PMC122550.
    92. Weinglass AB, Sondej M, Kaback HR. Manipulating conformational equilibria in the lactose permease of Escherichia coli. J Mol Biol. 2002 Jan 25; 315(4):561-71. PMID: 11812130.
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    93. Zhang W, Guan L, Kaback HR. Helices VII and X in the lactose permease of Escherichia coli: proximity and ligand-induced distance changes. J Mol Biol. 2002 Jan 04; 315(1):53-62. PMID: 11771965.
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    94. Sahin-Tóth M, Lawrence MC, Nishio T, Kaback HR. The C-4 hydroxyl group of galactopyranosides is the major determinant for ligand recognition by the lactose permease of Escherichia coli. Biochemistry. 2001 Oct 30; 40(43):13015-9. PMID: 11669639.
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    95. Guan L, Weinglass AB, Kaback HR. Helix packing in the lactose permease of Escherichia coli: localization of helix VI. J Mol Biol. 2001 Sep 07; 312(1):69-77. PMID: 11545586.
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    96. Kwaw I, Zen KC, Hu Y, Kaback HR. Site-directed sulfhydryl labeling of the lactose permease of Escherichia coli: helices IV and V that contain the major determinants for substrate binding. Biochemistry. 2001 Sep 04; 40(35):10491-9. PMID: 11523990.
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    97. Kaback HR, Sahin-Tóth M, Weinglass AB. The kamikaze approach to membrane transport. Nat Rev Mol Cell Biol. 2001 Aug; 2(8):610-20. PMID: 11483994.
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    98. Sahin-Toth M, Kaback HR. Arg-302 facilitates deprotonation of Glu-325 in the transport mechanism of the lactose permease from Escherichiacoli. Proc Natl Acad Sci U S A. 2001 May 22; 98(11):6068-73. PMID: 11353849; PMCID: PMC33423.
    99. Voss J, Wu J, Hubbell WL, Jacques V, Meares CF, Kaback HR. Helix packing in the lactose permease of Escherichia coli: distances between site-directed nitroxides and a lanthanide. Biochemistry. 2001 Mar 13; 40(10):3184-8. PMID: 11258934.
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    100. Wolin CD, Kaback HR. Functional estimation of loop-helix boundaries in the lactose permease of Escherichia coli by single amino acid deletion analysis. Biochemistry. 2001 Feb 20; 40(7):1996-2003. PMID: 11329266.
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    101. Weinglass AB, Smirnova IN, Kaback HR. Engineering conformational flexibility in the lactose permease of Escherichia coli: use of glycine-scanning mutagenesis to rescue mutant Glu325-->Asp. Biochemistry. 2001 Jan 23; 40(3):769-76. PMID: 11170394.
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    102. Zhang W, Kaback HR. Effect of the lipid phase transition on the lactose permease from Escherichia coli. Biochemistry. 2000 Nov 28; 39(47):14538-42. PMID: 11087408.
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    103. Sahin-Tóth M, Karlin A, Kaback HR. Unraveling the mechanism of the lactose permease of Escherichia coli. Proc Natl Acad Sci U S A. 2000 Sep 26; 97(20):10729-32. PMID: 10984523; PMCID: PMC27091.
    104. Zhao M, Kálai T, Hideg K, Altenbach C, Hubbell WL, Kaback HR. Binding of spin-labeled galactosides to the lactose permease of Escherichia coli. Biochemistry. 2000 Sep 19; 39(37):11381-8. PMID: 10985783.
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    105. Venkatesan P, Kwaw I, Hu Y, Kaback HR. Site-directed sulfhydryl labeling of the lactose permease of Escherichia coli: helix VII. Biochemistry. 2000 Sep 05; 39(35):10641-8. PMID: 10978147.
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    106. Venkatesan P, Liu Z, Hu Y, Kaback HR. Site-directed sulfhydryl labeling of the lactose permease of Escherichia coli: N-ethylmaleimide-sensitive face of helix II. Biochemistry. 2000 Sep 05; 39(35):10649-55. PMID: 10978148.
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    107. Venkatesan P, Hu Y, Kaback HR. Site-directed sulfhydryl labeling of the lactose permease of Escherichia coli: helix X. Biochemistry. 2000 Sep 05; 39(35):10656-61. PMID: 10978149.
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    108. Weinglass AB, Kaback HR. The central cytoplasmic loop of the major facilitator superfamily of transport proteins governs efficient membrane insertion. Proc Natl Acad Sci U S A. 2000 Aug 01; 97(16):8938-43. PMID: 10880570; PMCID: PMC16800.
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    110. Wolin CD, Kaback HR. Thiol cross-linking of transmembrane domains IV and V in the lactose permease of Escherichia coli. Biochemistry. 2000 May 23; 39(20):6130-5. PMID: 10821686.
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    112. Sahin-Tóth M, Akhoon KM, Runner J, Kaback HR. Ligand recognition by the lactose permease of Escherichia coli: specificity and affinity are defined by distinct structural elements of galactopyranosides. Biochemistry. 2000 May 02; 39(17):5097-103. PMID: 10819976.
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    113. le Coutre J, Whitelegge JP, Gross A, Turk E, Wright EM, Kaback HR, Faull KF. Proteomics on full-length membrane proteins using mass spectrometry. Biochemistry. 2000 Apr 18; 39(15):4237-42. PMID: 10757971.
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    114. Kwaw I, Sun J, Kaback HR. Thiol cross-linking of cytoplasmic loops in the lactose permease of Escherichia coli. Biochemistry. 2000 Mar 21; 39(11):3134-40. PMID: 10715135.
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    115. Wang Q, Kaback HR. Location of helix III in the lactose permease of Escherichia coli as determined by site-directed thiol cross-linking. Biochemistry. 1999 Dec 21; 38(51):16777-82. PMID: 10606509.
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    116. Zhao M, Zen KC, Hernandez-Borrell J, Altenbach C, Hubbell WL, Kaback HR. Nitroxide scanning electron paramagnetic resonance of helices IV and V and the intervening loop in the lactose permease of Escherichia coli. Biochemistry. 1999 Nov 30; 38(48):15970-7. PMID: 10625464.
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    117. Weinglass AB, Kaback HR. Conformational flexibility at the substrate binding site in the lactose permease of Escherichia coli. Proc Natl Acad Sci U S A. 1999 Sep 28; 96(20):11178-82. PMID: 10500150; PMCID: PMC18007.
    118. Whitelegge JP, le Coutre J, Lee JC, Engel CK, Privé GG, Faull KF, Kaback HR. Toward the bilayer proteome, electrospray ionization-mass spectrometry of large, intact transmembrane proteins. Proc Natl Acad Sci U S A. 1999 Sep 14; 96(19):10695-8. PMID: 10485888; PMCID: PMC17945.
    119. Wang Q, Kaback HR. Proximity relationships between helices I and XI or XII in the lactose permease of Escherichia coli determined by site-directed thiol cross-linking. J Mol Biol. 1999 Aug 20; 291(3):683-92. PMID: 10448046.
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    120. Wolin CD, Kaback HR. Estimating loop-helix interfaces in a polytopic membrane protein by deletion analysis. Biochemistry. 1999 Jun 29; 38(26):8590-7. PMID: 10387107.
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    121. Zhao M, Zen KC, Hubbell WL, Kaback HR. Proximity between Glu126 and Arg144 in the lactose permease of Escherichia coli. Biochemistry. 1999 Jun 08; 38(23):7407-12. PMID: 10360937.
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    122. Sondej M, Sun J, Seok YJ, Kaback HR, Peterkofsky A. Deduction of consensus binding sequences on proteins that bind IIAGlc of the phosphoenolpyruvate:sugar phosphotransferase system by cysteine scanning mutagenesis of Escherichia coli lactose permease. Proc Natl Acad Sci U S A. 1999 Mar 30; 96(7):3525-30. PMID: 10097069; PMCID: PMC22326.
    123. Sun J, Voss J, Hubbell WL, Kaback HR. Proximity between periplasmic loops in the lactose permease of Escherichia coli as determined by site-directed spin labeling. Biochemistry. 1999 Mar 09; 38(10):3100-5. PMID: 10074363.
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    124. Wang Q, Kaback HR. Helix packing in the lactose permease of Escherichia coli determined by site-directed thiol cross-linking: helix I is close to helices V and XI. Biochemistry. 1999 Mar 09; 38(10):3120-6. PMID: 10074366.
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    125. Zhuang J, Privé GG, Werner GE, Ringler P, Kaback HR, Engel A. Two-dimensional crystallization of Escherichia coli lactose permease. J Struct Biol. 1999 Mar; 125(1):63-75. PMID: 10196117.
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    126. Wu J, Hardy D, Kaback HR. Tertiary contacts of helix V in the lactose permease determined by site-directed chemical cross-linking in situ. Biochemistry. 1999 Feb 23; 38(8):2320-5. PMID: 10029525.
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    127. Wu J, Hardy D, Kaback HR. Site-directed chemical cross-linking demonstrates that helix IV is close to helices VII and XI in the lactose permease. Biochemistry. 1999 Feb 09; 38(6):1715-20. PMID: 10026249.
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    128. Sahin-Tóth M, le Coutre J, Kharabi D, le Maire G, Lee JC, Kaback HR. Characterization of Glu126 and Arg144, two residues that are indispensable for substrate binding in the lactose permease of Escherichia coli. Biochemistry. 1999 Jan 12; 38(2):813-9. PMID: 9888822.
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    129. Pouny Y, Weitzman C, Kaback HR. In vitro biotinylation provides quantitative recovery of highly purified active lactose permease in a single step. Biochemistry. 1998 Nov 10; 37(45):15713-9. PMID: 9843376.
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    130. Wu J, Hardy D, Kaback HR. Tilting of helix I and ligand-induced changes in the lactose permease determined by site-directed chemical cross-linking in situ. Biochemistry. 1998 Nov 10; 37(45):15785-90. PMID: 9843383.
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    131. Wu J, Hardy D, Kaback HR. Transmembrane helix tilting and ligand-induced conformational changes in the lactose permease determined by site-directed chemical crosslinking in situ. J Mol Biol. 1998 Oct 09; 282(5):959-67. PMID: 9753547.
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    132. Frillingos S, Sahin-Tóth M, Wu J, Kaback HR. Cys-scanning mutagenesis: a novel approach to structure function relationships in polytopic membrane proteins. FASEB J. 1998 Oct; 12(13):1281-99. PMID: 9761772.
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    133. Venkatesan P, Kaback HR. The substrate-binding site in the lactose permease of Escherichia coli. Proc Natl Acad Sci U S A. 1998 Aug 18; 95(17):9802-7. PMID: 9707556; PMCID: PMC21417.
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    135. Sun J, Kemp CR, Kaback HR. Ligand-induced changes in periplasmic loops in the lactose permease of Escherichia coli. Biochemistry. 1998 Jun 02; 37(22):8020-6. PMID: 9609695.
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    136. Voss J, Sun J, Venkatesan P, Kaback HR. Sulfhydryl oxidation of mutants with cysteine in place of acidic residues in the lactose permease. Biochemistry. 1998 Jun 02; 37(22):8191-6. PMID: 9609715.
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    137. le Coutre J, Kaback HR, Patel CK, Heginbotham L, Miller C. Fourier transform infrared spectroscopy reveals a rigid alpha-helical assembly for the tetrameric Streptomyces lividans K+ channel. Proc Natl Acad Sci U S A. 1998 May 26; 95(11):6114-7. PMID: 9600926; PMCID: PMC27594.
    138. Wang Q, Voss J, Hubbell WL, Kaback HR. Proximity of helices VIII (Ala273) and IX (Met299) in the lactose permease of Escherichia coli. Biochemistry. 1998 Apr 07; 37(14):4910-5. PMID: 9538009.
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    139. Voss J, Hubbell WL, Kaback HR. Helix packing in the lactose permease determined by metal-nitroxide interaction. Biochemistry. 1998 Jan 06; 37(1):211-6. PMID: 9425041.
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    140. He MM, Kaback HR. In vitro folding of a membrane protein: effect of denaturation and renaturation on substrate binding by the lactose permease of Escherichia coli. Mol Membr Biol. 1998 Jan-Mar; 15(1):15-20. PMID: 9595550.
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    141. Voss J, Hubbell WL, Hernandez-Borrell J, Kaback HR. Site-directed spin-labeling of transmembrane domain VII and the 4B1 antibody epitope in the lactose permease of Escherichia coli. Biochemistry. 1997 Dec 09; 36(49):15055-61. PMID: 9398232.
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    142. Seok YJ, Sun J, Kaback HR, Peterkofsky A. Topology of allosteric regulation of lactose permease. Proc Natl Acad Sci U S A. 1997 Dec 09; 94(25):13515-9. PMID: 9391057; PMCID: PMC28337.
    143. Frillingos S, Gonzalez A, Kaback HR. Cysteine-scanning mutagenesis of helix IV and the adjoining loops in the lactose permease of Escherichia coli: Glu126 and Arg144 are essential. off. Biochemistry. 1997 Nov 25; 36(47):14284-90. PMID: 9400367.
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    144. Braun P, Persson B, Kaback HR, von Heijne G. Alanine insertion scanning mutagenesis of lactose permease transmembrane helices. J Biol Chem. 1997 Nov 21; 272(47):29566-71. PMID: 9368019.
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    145. Wang Q, Matsushita K, de Foresta B, le Maire M, Kaback HR. Ligand-induced movement of helix X in the lactose permease from Escherichia coli: a fluorescence quenching study. Biochemistry. 1997 Nov 18; 36(46):14120-7. PMID: 9369484.
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    146. He MM, Voss J, Hubbell WL, Kaback HR. Arginine 302 (helix IX) in the lactose permease of Escherichia coli is in close proximity to glutamate 269 (helix VIII) as well as glutamate 325. Biochemistry. 1997 Nov 04; 36(44):13682-7. PMID: 9354638.
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    147. He MM, Kaback HR. Interaction between residues Glu269 (helix VIII) and His322 (helix X) of the lactose permease of Escherichia coli is essential for substrate binding. Biochemistry. 1997 Nov 04; 36(44):13688-92. PMID: 9354639.
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    148. Kaback HR, Wu J. From membrane to molecule to the third amino acid from the left with a membrane transport protein. Q Rev Biophys. 1997 Nov; 30(4):333-64. PMID: 9634651.
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    149. Sun J, Kaback HR. Proximity of periplasmic loops in the lactose permease of Escherichia coli determined by site-directed cross-linking. Biochemistry. 1997 Sep 30; 36(39):11959-65. PMID: 9305990.
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    150. le Coutre J, Narasimhan LR, Patel CK, Kaback HR. The lipid bilayer determines helical tilt angle and function in lactose permease of Escherichia coli. Proc Natl Acad Sci U S A. 1997 Sep 16; 94(19):10167-71. PMID: 9294181; PMCID: PMC23333.
    151. Kaback HR, Voss J, Wu J. Helix packing in polytopic membrane proteins: the lactose permease of Escherichia coli. Curr Opin Struct Biol. 1997 Aug; 7(4):537-42. PMID: 9266176.
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    152. Wu J, Kaback HR. Helix proximity and ligand-induced conformational changes in the lactose permease of Escherichia coli determined by site-directed chemical crosslinking. J Mol Biol. 1997 Jul 11; 270(2):285-93. PMID: 9236129.
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    153. Sun J, Frillingos S, Kaback HR. Binding of monoclonal antibody 4B1 to homologs of the lactose permease of Escherichia coli. Protein Sci. 1997 Jul; 6(7):1503-10. PMID: 9232651; PMCID: PMC2143751.
    154. Frillingos S, Wu J, Venkatesan P, Kaback HR. Binding of ligand or monoclonal antibody 4B1 induces discrete structural changes in the lactose permease of Escherichia coli. Biochemistry. 1997 May 27; 36(21):6408-14. PMID: 9174357.
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    155. Kaback HR. A molecular mechanism for energy coupling in a membrane transport protein, the lactose permease of Escherichia coli. Proc Natl Acad Sci U S A. 1997 May 27; 94(11):5539-43. PMID: 9159108; PMCID: PMC20814.
    156. Merickel A, Kaback HR, Edwards RH. Charged residues in transmembrane domains II and XI of a vesicular monoamine transporter form a charge pair that promotes high affinity substrate recognition. J Biol Chem. 1997 Feb 28; 272(9):5403-8. PMID: 9038139.
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    157. Frillingos S, Ujwal ML, Sun J, Kaback HR. The role of helix VIII in the lactose permease of Escherichia coli: I. Cys-scanning mutagenesis. Protein Sci. 1997 Feb; 6(2):431-7. PMID: 9041646; PMCID: PMC2143654.
    158. Frillingos S, Kaback HR. The role of helix VIII in the lactose permease of Escherichia coli: II. Site-directed sulfhydryl modification. Protein Sci. 1997 Feb; 6(2):438-43. PMID: 9041647; PMCID: PMC2143636.
    159. Frillingos S, Sun J, Gonzalez A, Kaback HR. Cysteine-scanning mutagenesis of helix II and flanking hydrophilic domains in the lactose permease of Escherichia coli. Biochemistry. 1997 Jan 07; 36(1):269-73. PMID: 8993343.
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    160. Sun J, Li J, Carrasco N, Kaback HR. The last two cytoplasmic loops in the lactose permease of Escherichia coli comprise a discontinuous epitope for a monoclonal antibody. Biochemistry. 1997 Jan 07; 36(1):274-80. PMID: 8993344.
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    161. Wu J, Kaback HR. A general method for determining helix packing in membrane proteins in situ: helices I and II are close to helix VII in the lactose permease of Escherichia coli. Proc Natl Acad Sci U S A. 1996 Dec 10; 93(25):14498-502. PMID: 8962080; PMCID: PMC26161.
    162. Frillingos S, Kaback HR. Chemical rescue of Asp237-->Ala and Lys358-->Ala mutants in the lactose permease of Escherichia coli. Biochemistry. 1996 Oct 15; 35(41):13363-7. PMID: 8873603.
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    163. He MM, Sun J, Kaback HR. Cysteine-scanning mutagenesis of transmembrane domain XII and the flanking periplasmic loop in the lactose permease of EScherichia coli. Biochemistry. 1996 Oct 01; 35(39):12909-14. PMID: 8841135.
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    164. Voss J, He MM, Hubbell WL, Kaback HR. Site-directed spin labeling demonstrates that transmembrane domain XII in the lactose permease of Escherichia coli is an alpha-helix. Biochemistry. 1996 Oct 01; 35(39):12915-8. PMID: 8841136.
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    165. Wu J, Voss J, Hubbell WL, Kaback HR. Site-directed spin labeling and chemical crosslinking demonstrate that helix V is close to helices VII and VIII in the lactose permease of Escherichia coli. Proc Natl Acad Sci U S A. 1996 Sep 17; 93(19):10123-7. PMID: 8816762; PMCID: PMC38347.
    166. Frillingos S, Kaback HR. Monoclonal antibody 4B1 alters the pKa of a carboxylic acid at position 325 (helix X) of the lactose permease of Escherichia coli. Biochemistry. 1996 Aug 06; 35(31):10166-71. PMID: 8756481.
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    167. Bogdanov M, Sun J, Kaback HR, Dowhan W. A phospholipid acts as a chaperone in assembly of a membrane transport protein. J Biol Chem. 1996 May 17; 271(20):11615-8. PMID: 8662750.
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    168. Wu J, Sun J, Kaback HR. Purification and functional characterization of the C-terminal half of the lactose permease of Escherichia coli. Biochemistry. 1996 Apr 23; 35(16):5213-9. PMID: 8611506.
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    169. Frillingos S, Kaback HR. Cysteine-scanning mutagenesis of helix VI and the flanking hydrophilic domains on the lactose permease of Escherichia coli. Biochemistry. 1996 Apr 23; 35(16):5333-8. PMID: 8611521.
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    170. Frillingos S, Kaback HR. Probing the conformation of the lactose permease of Escherichia coli by in situ site-directed sulfhydryl modification. Biochemistry. 1996 Apr 02; 35(13):3950-6. PMID: 8672426.
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    171. Pourcher T, Bibi E, Kaback HR, Leblanc G. Membrane topology of the melibiose permease of Escherichia coli studied by melB-phoA fusion analysis. Biochemistry. 1996 Apr 02; 35(13):4161-8. PMID: 8672452.
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    172. Sahin-Tóth M, Kaback HR, Friedlander M. Association between the amino- and carboxyl-terminal halves of lactose permease is specific and mediated by multiple transmembrane domains. Biochemistry. 1996 Feb 13; 35(6):2016-21. PMID: 8639686.
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    173. Prive GG, Kaback HR. Engineering the lac permease for purification and crystallization. J Bioenerg Biomembr. 1996 Feb; 28(1):29-34. PMID: 8786234.
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    174. Sun J, Wu J, Carrasco N, Kaback HR. Identification of the epitope for monoclonal antibody 4B1 which uncouples lactose and proton translocation in the lactose permease of Escherichia coli. Biochemistry. 1996 Jan 23; 35(3):990-8. PMID: 8547282.
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    175. Voss J, Salwinski L, Kaback HR, Hubbell WL. A method for distance determination in proteins using a designed metal ion binding site and site-directed spin labeling: evaluation with T4 lysozyme. Proc Natl Acad Sci U S A. 1995 Dec 19; 92(26):12295-9. PMID: 8618888; PMCID: PMC40343.
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    178. He MM, Voss J, Hubbell WL, Kaback HR. Use of designed metal-binding sites to study helix proximity in the lactose permease of Escherichia coli. 1. Proximity of helix VII (Asp237 and Asp240) with helices X (Lys319) and XI (Lys358). Biochemistry. 1995 Dec 05; 34(48):15661-6. PMID: 7495795.
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    179. Ujwal ML, Jung H, Bibi E, Manoil C, Altenbach C, Hubbell WL, Kaback HR. Membrane topology of helices VII and XI in the lactose permease of Escherichia coli studied by lacY-phoA fusion analysis and site-directed spectroscopy. Biochemistry. 1995 Nov 14; 34(45):14909-17. PMID: 7578103.
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    180. Weitzman C, Consler TG, Kaback HR. Fluorescence of native single-Trp mutants in the lactose permease from Escherichia coli: structural properties and evidence for a substrate-induced conformational change. Protein Sci. 1995 Nov; 4(11):2310-8. PMID: 8563627; PMCID: PMC2143026.
    181. Wu J, Perrin DM, Sigman DS, Kaback HR. Helix packing of lactose permease in Escherichia coli studied by site-directed chemical cleavage. Proc Natl Acad Sci U S A. 1995 Sep 26; 92(20):9186-90. PMID: 7568098; PMCID: PMC40949.
    182. Frillingos S, Sahin-Tóth M, Lengeler JW, Kaback HR. Helix packing in the sucrose permease of Escherichia coli: properties of engineered charge pairs between helices VII and XI. Biochemistry. 1995 Jul 25; 34(29):9368-73. PMID: 7626606.
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    183. Weitzman C, Kaback HR. Cysteine scanning mutagenesis of helix V in the lactose permease of Escherichia coli. Biochemistry. 1995 Jul 25; 34(29):9374-9. PMID: 7626607.
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    184. Wu J, Frillingos S, Kaback HR. Dynamics of lactose permease of Escherichia coli determined by site-directed chemical labeling and fluorescence spectroscopy. Biochemistry. 1995 Jul 04; 34(26):8257-63. PMID: 7599118.
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    185. Jung K, Voss J, He M, Hubbell WL, Kaback HR. Engineering a metal binding site within a polytopic membrane protein, the lactose permease of Escherichia coli. Biochemistry. 1995 May 16; 34(19):6272-7. PMID: 7756253.
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    186. Sahin-Tóth M, Frillingos S, Lengeler JW, Kaback HR. Active transport by the CscB permease in Escherichia coli K-12. Biochem Biophys Res Commun. 1995 Mar 28; 208(3):1116-23. PMID: 7535526.
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    187. Zen KH, Consler TG, Kaback HR. Insertion of the polytopic membrane protein lactose permease occurs by multiple mechanisms. Biochemistry. 1995 Mar 14; 34(10):3430-7. PMID: 7880837.
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    188. Sahin-Tóth M, Dunten RL, Kaback HR. Design of a membrane protein for site-specific proteolysis: properties of engineered factor Xa protease sites in the lactose permease of Escherichia coli. Biochemistry. 1995 Jan 31; 34(4):1107-12. PMID: 7827058.
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    189. Jung K, Jung H, Colacurcio P, Kaback HR. Role of glycine residues in the structure and function of lactose permease, an Escherichia coli membrane transport protein. Biochemistry. 1995 Jan 24; 34(3):1030-9. PMID: 7827019.
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    190. Wu J, Frillingos S, Voss J, Kaback HR. Ligand-induced conformational changes in the lactose permease of Escherichia coli: evidence for two binding sites. Protein Sci. 1994 Dec; 3(12):2294-301. PMID: 7756985; PMCID: PMC2142758.
    191. Sahin-Tóth M, Frillingos S, Bibi E, Gonzalez A, Kaback HR. The role of transmembrane domain III in the lactose permease of Escherichia coli. Protein Sci. 1994 Dec; 3(12):2302-10. PMID: 7756986; PMCID: PMC2142773.
    192. Kaback HR, Frillingos S, Jung H, Jung K, Privé GG, Ujwal ML, Weitzman C, Wu J, Zen K. The lactose permease meets Frankenstein. J Exp Biol. 1994 Nov; 196:183-95. PMID: 7823021.
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    193. Jung H, Jung K, Kaback HR. Cysteine 148 in the lactose permease of Escherichia coli is a component of a substrate binding site. 1. Site-directed mutagenesis studies. Biochemistry. 1994 Oct 11; 33(40):12160-5. PMID: 7918437.
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    194. Wu J, Kaback HR. Cysteine 148 in the lactose permease of Escherichia coli is a component of a substrate binding site. 2. Site-directed fluorescence studies. Biochemistry. 1994 Oct 11; 33(40):12166-71. PMID: 7918438.
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    195. Zen KH, McKenna E, Bibi E, Hardy D, Kaback HR. Expression of lactose permease in contiguous fragments as a probe for membrane-spanning domains. Biochemistry. 1994 Jul 12; 33(27):8198-206. PMID: 8031753.
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    196. Frillingos S, Sahin-Tóth M, Persson B, Kaback HR. Cysteine-scanning mutagenesis of putative helix VII in the lactose permease of Escherichia coli. Biochemistry. 1994 Jul 05; 33(26):8074-81. PMID: 8025113.
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    197. Jung H, Jung K, Kaback HR. A conformational change in the lactose permease of Escherichia coli is induced by ligand binding or membrane potential. Protein Sci. 1994 Jul; 3(7):1052-7. PMID: 7920250; PMCID: PMC2142900.
    198. Privé GG, Verner GE, Weitzman C, Zen KH, Eisenberg D, Kaback HR. Fusion proteins as tools for crystallization: the lactose permease from Escherichia coli. Acta Crystallogr D Biol Crystallogr. 1994 Jul 01; 50(Pt 4):375-9. PMID: 15299388.
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    199. Sahin-Tóth M, Lawrence MC, Kaback HR. Properties of permease dimer, a fusion protein containing two lactose permease molecules from Escherichia coli. Proc Natl Acad Sci U S A. 1994 Jun 07; 91(12):5421-5. PMID: 8202501; PMCID: PMC44007.
    200. Jung K, Jung H, Kaback HR. Dynamics of lactose permease of Escherichia coli determined by site-directed fluorescence labeling. Biochemistry. 1994 Apr 05; 33(13):3980-5. PMID: 8142402.
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    201. Sahin-Tóth M, Persson B, Schwieger J, Cohan P, Kaback HR. Cysteine scanning mutagenesis of the N-terminal 32 amino acid residues in the lactose permease of Escherichia coli. Protein Sci. 1994 Feb; 3(2):240-7. PMID: 8003960; PMCID: PMC2142801.
    202. Ujwal ML, Sahin-Tóth M, Persson B, Kaback HR. Role of glutamate-269 in the lactose permease of Escherichia coli. Mol Membr Biol. 1994 Jan-Mar; 11(1):9-16. PMID: 7912610.
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    203. Kaback HR, Jung K, Jung H, Wu J, Privé GG, Zen K. What's new with lactose permease. J Bioenerg Biomembr. 1993 Dec; 25(6):627-36. PMID: 8144491.
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    204. Dunten RL, Sahin-Tóth M, Kaback HR. Cysteine scanning mutagenesis of putative helix XI in the lactose permease of Escherichia coli. Biochemistry. 1993 Nov 30; 32(47):12644-50. PMID: 8251482.
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    205. Jung K, Jung H, Wu J, Privé GG, Kaback HR. Use of site-directed fluorescence labeling to study proximity relationships in the lactose permease of Escherichia coli. Biochemistry. 1993 Nov 23; 32(46):12273-8. PMID: 8241112.
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    206. Sahin-Tóth M, Kaback HR. Properties of interacting aspartic acid and lysine residues in the lactose permease of Escherichia coli. Biochemistry. 1993 Sep 28; 32(38):10027-35. PMID: 8399130.
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    207. Consler TG, Persson BL, Jung H, Zen KH, Jung K, Privé GG, Verner GE, Kaback HR. Properties and purification of an active biotinylated lactose permease from Escherichia coli. Proc Natl Acad Sci U S A. 1993 Aug 01; 90(15):6934-8. PMID: 8346199; PMCID: PMC47049.
    208. Sahin-Tóth M, Kaback HR. Cysteine scanning mutagenesis of putative transmembrane helices IX and X in the lactose permease of Escherichia coli. Protein Sci. 1993 Jun; 2(6):1024-33. PMID: 8318887; PMCID: PMC2142399.
    209. van Iwaarden PR, Driessen AJ, Lolkema JS, Kaback HR, Konings WN. Exchange, efflux, and substrate binding by cysteine mutants of the lactose permease of Escherichia coli. Biochemistry. 1993 May 25; 32(20):5419-24. PMID: 8499445.
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    210. Dunten RL, Sahin-Tóth M, Kaback HR. Role of the charge pair aspartic acid-237-lysine-358 in the lactose permease of Escherichia coli. Biochemistry. 1993 Mar 30; 32(12):3139-45. PMID: 8457574.
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    211. Sahin-Tóth M, Dunten RL, Kaback HR. The lactose permease of Escherichia coli: a paradigm for membrane transport proteins. Soc Gen Physiol Ser. 1993; 48:1-9. PMID: 8503038.
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    212. McKenna E, Hardy D, Kaback HR. Insertional mutagenesis of hydrophilic domains in the lactose permease of Escherichia coli. Proc Natl Acad Sci U S A. 1992 Dec 15; 89(24):11954-8. PMID: 1465425; PMCID: PMC50676.
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    214. Persson B, Roepe PD, Patel L, Lee J, Kaback HR. Site-directed mutagenesis of lysine 319 in the lactose permease of Escherichia coli. Biochemistry. 1992 Sep 22; 31(37):8892-7. PMID: 1390676.
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    215. Kaback HR. The lactose permease of Escherichia coli: a paradigm for membrane transport proteins. Biochim Biophys Acta. 1992 Jul 17; 1101(2):210-3. PMID: 1633187.
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    216. Bibi E, Stearns SM, Kaback HR. The N-terminal 22 amino acid residues in the lactose permease of Escherichia coli are not obligatory for membrane insertion or transport activity. Proc Natl Acad Sci U S A. 1992 Apr 15; 89(8):3180-4. PMID: 1565610; PMCID: PMC48829.
    217. McKenna E, Hardy D, Kaback HR. Evidence that the final turn of the last transmembrane helix in the lactose permease is required for folding. J Biol Chem. 1992 Apr 05; 267(10):6471-4. PMID: 1551862.
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    218. Bibi E, Kaback HR. Functional complementation of internal deletion mutants in the lactose permease of Escherichia coli. Proc Natl Acad Sci U S A. 1992 Mar 01; 89(5):1524-8. PMID: 1542643; PMCID: PMC48484.
    219. Kaback HR. In and out and up and down with lac permease. Int Rev Cytol. 1992; 137:97-125. PMID: 1330966.
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    220. van Iwaarden PR, Pastore JC, Konings WN, Kaback HR. Construction of a functional lactose permease devoid of cysteine residues. Biochemistry. 1991 Oct 08; 30(40):9595-600. PMID: 1911745.
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    221. van Iwaarden PR, Driessen AJ, Menick DR, Kaback HR, Konings WN. Characterization of purified, reconstituted site-directed cysteine mutants of the lactose permease of Escherichia coli. J Biol Chem. 1991 Aug 25; 266(24):15688-92. PMID: 1874727.
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    222. Bibi E, Verner G, Chang CY, Kaback HR. Organization and stability of a polytopic membrane protein: deletion analysis of the lactose permease of Escherichia coli. Proc Natl Acad Sci U S A. 1991 Aug 15; 88(16):7271-5. PMID: 1871132; PMCID: PMC52276.
    223. McKenna E, Hardy D, Pastore JC, Kaback HR. Sequential truncation of the lactose permease over a three-amino acid sequence near the carboxyl terminus leads to progressive loss of activity and stability. Proc Natl Acad Sci U S A. 1991 Apr 15; 88(8):2969-73. PMID: 2014218; PMCID: PMC51365.
    224. Lolkema JS, Carrasco N, Kaback HR. Kinetic analysis of lactose exchange in proteoliposomes reconstituted with purified lac permease. Biochemistry. 1991 Feb 05; 30(5):1284-90. PMID: 1991109.
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    225. Consler TG, Tsolas O, Kaback HR. Role of proline residues in the structure and function of a membrane transport protein. Biochemistry. 1991 Feb 05; 30(5):1291-8. PMID: 1991110.
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    226. Hinkle PC, Hinkle PV, Kaback HR. Information content of amino acid residues in putative helix VIII of the lac permease from Escherichia coli. Biochemistry. 1990 Dec 11; 29(49):10989-94. PMID: 2271693.
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    227. Kaback HR, Bibi E, Roepe PD. Beta-galactoside transport in E. coli: a functional dissection of lac permease. Trends Biochem Sci. 1990 Aug; 15(8):309-14. PMID: 2204157.
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    228. Kaback HR. The lac permease of Escherichia coli: a prototypic energy-transducing membrane protein. Biochim Biophys Acta. 1990 Jul 25; 1018(2-3):160-2. PMID: 2203471.
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    229. Bibi E, Kaback HR. In vivo expression of the lacY gene in two segments leads to functional lac permease. Proc Natl Acad Sci U S A. 1990 Jun; 87(11):4325-9. PMID: 2190220; PMCID: PMC54102.
    230. Roepe PD, Consler TG, Menezes ME, Kaback HR. The lac permease of Escherichia coli: site-directed mutagenesis studies on the mechanism of beta-galactoside/H+ symport. Res Microbiol. 1990 Mar-Apr; 141(3):290-308. PMID: 2177909.
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    231. Kaback HR. Lac permease of Escherichia coli: on the path of the proton. Philos Trans R Soc Lond B Biol Sci. 1990 Jan 30; 326(1236):425-36. PMID: 1970647.
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    232. Pourcher T, Bassilana M, Sarkar HK, Kaback HR, Leblanc G. Melibiose permease and alpha-galactosidase of Escherichia coli: identification by selective labeling using a T7 RNA polymerase/promoter expression system. Biochemistry. 1990 Jan 23; 29(3):690-6. PMID: 2159786.
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    233. Pourcher T, Sarkar HK, Bassilana M, Kaback HR, Leblanc G. Histidine-94 is the only important histidine residue in the melibiose permease of Escherichia coli. Proc Natl Acad Sci U S A. 1990 Jan; 87(1):468-72. PMID: 2404282; PMCID: PMC53285.
    234. Roepe PD, Kaback HR. Characterization and functional reconstitution of a soluble form of the hydrophobic membrane protein lac permease from Escherichia coli. Proc Natl Acad Sci U S A. 1989 Aug; 86(16):6087-91. PMID: 2668955; PMCID: PMC297780.
    235. Carrasco N, Püttner IB, Antes LM, Lee JA, Larigan JD, Lolkema JS, Roepe PD, Kaback HR. Characterization of site-directed mutants in the lac permease of Escherichia coli. 2. Glutamate-325 replacements. Biochemistry. 1989 Mar 21; 28(6):2533-9. PMID: 2567181.
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    236. Lee JA, Püttner IB, Kaback HR. Effect of distance and orientation between arginine-302, histidine-322, and glutamate-325 on the activity of lac permease from Escherichia coli. Biochemistry. 1989 Mar 21; 28(6):2540-4. PMID: 2567182.
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    237. Püttner IB, Sarkar HK, Padan E, Lolkema JS, Kaback HR. Characterization of site-directed mutants in the lac permease of Escherichia coli. 1. Replacement of histidine residues. Biochemistry. 1989 Mar 21; 28(6):2525-33. PMID: 2659072.
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    238. Lolkema JS, Püttner IB, Kaback HR. Site-directed mutagenesis of Pro327 in the lac permease of Escherichia coli. Biochemistry. 1988 Nov 01; 27(22):8307-10. PMID: 3072017.
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    239. Püttner IB, Kaback HR. lac permease of Escherichia coli containing a single histidine residue is fully functional. Proc Natl Acad Sci U S A. 1988 Mar; 85(5):1467-71. PMID: 3278314; PMCID: PMC279792.
    240. Kaback HR. Site-directed mutagenesis and ion-gradient driven active transport: on the path of the proton. Annu Rev Physiol. 1988; 50:243-56. PMID: 3288093.
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    241. Costello MJ, Escaig J, Matsushita K, Viitanen PV, Menick DR, Kaback HR. Purified lac permease and cytochrome o oxidase are functional as monomers. J Biol Chem. 1987 Dec 15; 262(35):17072-82. PMID: 2824513.
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    242. Kaback HR. Permease on parade: application of site-directed mutagenesis to ion-gradient driven active transport. Bioessays. 1987 Dec; 7(6):261-5. PMID: 3325054.
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    243. Menick DR, Carrasco N, Antes L, Patel L, Kaback HR. lac permease of Escherichia coli: arginine-302 as a component of the postulated proton relay. Biochemistry. 1987 Oct 20; 26(21):6638-44. PMID: 2827732.
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    244. Kaback HR. Use of site-directed mutagenesis to study the mechanism of a membrane transport protein. Biochemistry. 1987 Apr 21; 26(8):2071-6. PMID: 3304418.
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    245. Menick DR, Lee JA, Brooker RJ, Wilson TH, Kaback HR. Role of cysteine residues in the lac permease of Escherichia coli. Biochemistry. 1987 Feb 24; 26(4):1132-6. PMID: 3552042.
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    246. Kaback HR. Molecular biology of active transport: from membrane to molecule to mechanism. Harvey Lect. 1987-1988; 83:77-105. PMID: 3334141.
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    247. Püttner IB, Sarkar HK, Poonian MS, Kaback HR. lac permease of Escherichia coli: histidine-205 and histidine-322 play different roles in lactose/H+ symport. Biochemistry. 1986 Aug 12; 25(16):4483-5. PMID: 3533138.
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    248. Carrasco N, Antes LM, Poonian MS, Kaback HR. lac permease of Escherichia coli: histidine-322 and glutamic acid-325 may be components of a charge-relay system. Biochemistry. 1986 Aug 12; 25(16):4486-8. PMID: 2876725.
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    249. Sarkar HK, Menick DR, Viitanen PV, Poonian MS, Kaback HR. Site-specific mutagenesis of cysteine 148 to serine in the lac permease of Escherichia coli. J Biol Chem. 1986 Jul 05; 261(19):8914-8. PMID: 3087982.
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    250. Sarkar HK, Viitanen PV, Poonian MS, Kaback HR. Substitution of glutamine-60 with glutamic acid causes the lac permease of Escherichia coli to become temperature sensitive. Biochemistry. 1986 May 20; 25(10):2778-81. PMID: 2872916.
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    251. Sarkar HK, Viitanen PV, Padan E, Trumble WR, Poonian MS, McComas W, Kaback HR. Oligonucleotide-directed site-specific mutagenesis of the lac permease of Escherichia coli. Methods Enzymol. 1986; 125:214-30. PMID: 3520222.
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    252. Viitanen P, Newman MJ, Foster DL, Wilson TH, Kaback HR. Purification, reconstitution, and characterization of the lac permease of Escherichia coli. Methods Enzymol. 1986; 125:429-52. PMID: 3520229.
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    253. Kaback HR. Active transport in Escherichia coli: passage to permease. Annu Rev Biophys Biophys Chem. 1986; 15:279-319. PMID: 3521656.
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    254. Carrasco N, Herzlinger D, Danho W, Kaback HR. Preparation of monoclonal antibodies and site-directed polyclonal antibodies against the lac permease of Escherichia coli. Methods Enzymol. 1986; 125:453-67. PMID: 3520230.
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    255. Viitanen PV, Menick DR, Sarkar HK, Trumble WR, Kaback HR. Site-directed mutagenesis of cysteine-148 in the lac permease of Escherichia coli: effect on transport, binding, and sulfhydryl inactivation. Biochemistry. 1985 Dec 17; 24(26):7628-35. PMID: 3912006.
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    256. Menick DR, Sarkar HK, Poonian MS, Kaback HR. cys154 Is important for lac permease activity in Escherichia coli. Biochem Biophys Res Commun. 1985 Oct 15; 132(1):162-70. PMID: 2998353.
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    257. Padan E, Sarkar HK, Viitanen PV, Poonian MS, Kaback HR. Site-specific mutagenesis of histidine residues in the lac permease of Escherichia coli. Proc Natl Acad Sci U S A. 1985 Oct; 82(20):6765-8. PMID: 3901007; PMCID: PMC390767.
    258. Carrasco N, Herzlinger D, Dechiara S, Danho W, Kaback HR. Topology of the lac permease protein in the membrane of Escherichia coli. Ann N Y Acad Sci. 1985; 456:305-6. PMID: 3911839.
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    259. Viitanen PV, Sarkar HK, Menick D, Trumble WR, Padan E, McComas W, Poonian M, Kaback HR. Site-directed mutagenesis of the lacY gene of Escherichia coli. Ann N Y Acad Sci. 1985; 456:307-8. PMID: 3911840.
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    260. Herzlinger D, Carrasco N, Kaback HR. Functional and immunochemical characterization of a mutant of Escherichia coli energy uncoupled for lactose transport. Biochemistry. 1985 Jan 01; 24(1):221-9. PMID: 3888256.
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    261. Kaback HR. Proton electrochemical gradients and active transport: the saga of lac permease. Ann N Y Acad Sci. 1985; 456:291-304. PMID: 3004294.
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    262. Kaback HR. From membrane to molecule with the lac permease of Escherichia coli. Curr Top Cell Regul. 1985; 26:137-48. PMID: 3000693.
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    263. Costello MJ, Viitanen P, Carrasco N, Foster DL, Kaback HR. Morphology of proteoliposomes reconstituted with purified lac carrier protein from Escherichia coli. J Biol Chem. 1984 Dec 25; 259(24):15579-86. PMID: 6392300.
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    264. Carrasco N, Herzlinger D, Mitchell R, DeChiara S, Danho W, Gabriel TF, Kaback HR. Intramolecular dislocation of the COOH terminus of the lac carrier protein in reconstituted proteoliposomes. Proc Natl Acad Sci U S A. 1984 Aug; 81(15):4672-6. PMID: 6379649; PMCID: PMC391552.
    265. Herzlinger D, Viitanen P, Carrasco N, Kaback HR. Monoclonal antibodies against the lac carrier protein from Escherichia coli. 2. Binding studies with membrane vesicles and proteoliposomes reconstituted with purified lac carrier protein. Biochemistry. 1984 Jul 31; 23(16):3688-93. PMID: 6206889.
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    266. Carrasco N, Viitanen P, Herzlinger D, Kaback HR. Monoclonal antibodies against the lac carrier protein from Escherichia coli. 1. Functional studies. Biochemistry. 1984 Jul 31; 23(16):3681-7. PMID: 6383471.
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    267. Trumble WR, Viitanen PV, Sarkar HK, Poonian MS, Kaback HR. Site-directed mutagenesis of cys148 in the lac carrier protein of Escherichia coli. Biochem Biophys Res Commun. 1984 Mar 30; 119(3):860-7. PMID: 6370251.
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    268. Viitanen P, Garcia ML, Kaback HR. Purified reconstituted lac carrier protein from Escherichia coli is fully functional. Proc Natl Acad Sci U S A. 1984 Mar; 81(6):1629-33. PMID: 6324209; PMCID: PMC344971.
    269. Goldkorn T, Rimon G, Kempner ES, Kaback HR. Functional molecular weight of the lac carrier protein from Escherichia coli as studied by radiation inactivation analysis. Proc Natl Acad Sci U S A. 1984 Feb; 81(4):1021-5. PMID: 6230670; PMCID: PMC344755.
    270. Kaback HR, Carrasco N, Foster D, Garcia ML, Goldkorn T, Patel L, Viitanen P. The lac carrier protein from Escherichia coli. Soc Gen Physiol Ser. 1984; 38:323-30. PMID: 6364369.
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    271. Matsushita K, Patel L, Gennis RB, Kaback HR. Reconstitution of active transport in proteoliposomes containing cytochrome o oxidase and lac carrier protein purified from Escherichia coli. Proc Natl Acad Sci U S A. 1983 Aug; 80(16):4889-93. PMID: 6308657; PMCID: PMC384152.
    272. Goldkorn T, Rimon G, Kaback HR. Topology of the lac carrier protein in the membrane of Escherichia coli. Proc Natl Acad Sci U S A. 1983 Jun; 80(11):3322-6. PMID: 6344081; PMCID: PMC394034.
    273. Garcia ML, Viitanen P, Foster DL, Kaback HR. Mechanism of lactose translocation in proteoliposomes reconstituted with lac carrier protein purified from Escherichia coli. 1. Effect of pH and imposed membrane potential on efflux, exchange, and counterflow. Biochemistry. 1983 May 10; 22(10):2524-31. PMID: 6344920.
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    274. Viitanen P, Garcia ML, Foster DL, Kaczorowski GJ, Kaback HR. Mechanism of lactose translocation in proteoliposomes reconstituted with lac carrier protein purified from Escherichia coli. 2. Deuterium solvent isotope effects. Biochemistry. 1983 May 10; 22(10):2531-6. PMID: 6305403.
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    275. Foster DL, Boublik M, Kaback HR. Structure of the lac carrier protein of Escherichia coli. J Biol Chem. 1983 Jan 10; 258(1):31-4. PMID: 6336750.
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    276. Kaback HR. The lac carrier protein in Escherichia coli. J Membr Biol. 1983; 76(2):95-112. PMID: 6358502.
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    277. Patel L, Garcia ML, Kaback HR. Direct measurement of lactose/proton symport in Escherichia coli membrane vesicles: further evidence for the involvement of histidine residue(s). Biochemistry. 1982 Nov 09; 21(23):5805-10. PMID: 6295442.
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    278. Garcia ML, Patel L, Padan E, Kaback HR. Mechanism of lactose transport in Escherichia coli membrane vesicles: evidence for the involvement of histidine residue(s) in the response of the lac carrier to the proton electrochemical gradient. Biochemistry. 1982 Nov 09; 21(23):5800-5. PMID: 6295441.
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    279. Carrasco N, Tahara SM, Patel L, Goldkorn T, Kaback HR. Preparation, characterization, and properties of monoclonal antibodies against the lac carrier protein from Escherichia coli. Proc Natl Acad Sci U S A. 1982 Nov; 79(22):6894-8. PMID: 6757923; PMCID: PMC347240.
    280. Foster DL, Garcia ML, Newman MJ, Patel L, Kaback HR. Lactose-proton symport by purified lac carrier protein. Biochemistry. 1982 Oct 26; 21(22):5634-8. PMID: 6293552.
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    281. Newman MJ, Foster DL, Wilson TH, Kaback HR. Purification and reconstitution of functional lactose carrier from Escherichia coli. J Biol Chem. 1981 Nov 25; 256(22):11804-8. PMID: 7028742.
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    282. Robertson DE, Kaczorowski GJ, Garcia ML, Kaback HR. Active transport in membrane vesicles from Escherichia coli: the electrochemical proton gradient alters the distribution of the lac carrier between two different kinetic states. Biochemistry. 1980 Dec 09; 19(25):5692-702. PMID: 7006690.
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    283. Kaczorowski GJ, LeBlanc G, Kaback HR. Specific labeling of the lac carrier protein in membrane vesicles of Escherichia coli by a photoaffinity reagent. Proc Natl Acad Sci U S A. 1980 Nov; 77(11):6319-23. PMID: 7005896; PMCID: PMC350275.
    284. Cohn DE, Kaback HR. Mechanism of the melibiose porter in membrane vesicles of Escherichia coli. Biochemistry. 1980 Sep 02; 19(18):4237-43. PMID: 6998495.
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