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Kaback H.

TitleDistinguished Professor
InstitutionUniversity of California Los Angeles
DepartmentPhysiology
AddressMRL
Los Angeles CA 90095
Phone(310) 206-5055
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    TitleProfessor


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Smirnova I, Kasho V, Jiang X, Chen HM, Withers SG, Kaback H. Oversized galactosides as a probe for conformational dynamics in LacY. Proc Natl Acad Sci U S A. 2018 Apr 17; 115(16):4146-4151. PMID: 29602806.
      View in: PubMed
    2. Smirnova I, Kasho V, Jiang X, Kaback H. An Asymmetric Conformational Change in LacY. Biochemistry. 2017 04 04; 56(13):1943-1950. PMID: 28300394.
      View in: PubMed
    3. Grytsyk N, Sugihara J, Kaback H, Hellwig P. pKa of Glu325 in LacY. Proc Natl Acad Sci U S A. 2017 02 14; 114(7):1530-1535. PMID: 28154138.
      View in: PubMed
    4. Jiang X, Smirnova I, Kasho V, Wu J, Hirata K, Ke M, Pardon E, Steyaert J, Yan N, Kaback H. Crystal structure of a LacY-nanobody complex in a periplasmic-open conformation. Proc Natl Acad Sci U S A. 2016 11 01; 113(44):12420-12425. PMID: 27791182.
      View in: PubMed
    5. Serdiuk T, Balasubramaniam D, Sugihara J, Mari SA, Kaback H, Müller DJ. YidC assists the stepwise and stochastic folding of membrane proteins. Nat Chem Biol. 2016 Nov; 12(11):911-917. PMID: 27595331.
      View in: PubMed
    6. Jiang X, Andersson M, Chau BT, Wong LY, Villafuerte MK, Kaback H. Role of Conserved Gly-Gly Pairs on the Periplasmic Side of LacY. Biochemistry. 2016 08 09; 55(31):4326-32. PMID: 27438891.
      View in: PubMed
    7. Smirnova I, Kasho V, Jiang X, Pardon E, Steyaert J, Kaback H. Transient conformers of LacY are trapped by nanobodies. Proc Natl Acad Sci U S A. 2015 Nov 10; 112(45):13839-44. PMID: 26512108; PMCID: PMC4653160.
    8. Kumar H, Finer-Moore JS, Kaback H, Stroud RM. Structure of LacY with an a-substituted galactoside: Connecting the binding site to the protonation site. Proc Natl Acad Sci U S A. 2015 Jul 21; 112(29):9004-9. PMID: 26157133; PMCID: PMC4517220.
    9. Serdiuk T, Sugihara J, Mari SA, Kaback H, Müller DJ. Observing a lipid-dependent alteration in single lactose permeases. Structure. 2015 Apr 07; 23(4):754-61. PMID: 25800555; PMCID: PMC4394043.
    10. Hariharan P, Balasubramaniam D, Peterkofsky A, Kaback H, Guan L. Thermodynamic mechanism for inhibition of lactose permease by the phosphotransferase protein IIAGlc. Proc Natl Acad Sci U S A. 2015 Feb 24; 112(8):2407-12. PMID: 25675534; PMCID: PMC4345578.
    11. Kaback H. A chemiosmotic mechanism of symport. Proc Natl Acad Sci U S A. 2015 Feb 03; 112(5):1259-64. PMID: 25568085; PMCID: PMC4321259.
    12. Smirnova I, Kasho V, Jiang X, Pardon E, Steyaert J, Kaback H. Outward-facing conformers of LacY stabilized by nanobodies. Proc Natl Acad Sci U S A. 2014 Dec 30; 111(52):18548-53. PMID: 25512549; PMCID: PMC4284591.
    13. Smirnova I, Kasho V, Kaback H. Real-time conformational changes in LacY. Proc Natl Acad Sci U S A. 2014 Jun 10; 111(23):8440-5. PMID: 24872451; PMCID: PMC4060661.
    14. Serdiuk T, Madej MG, Sugihara J, Kawamura S, Mari SA, Kaback H, Müller DJ. Substrate-induced changes in the structural properties of LacY. Proc Natl Acad Sci U S A. 2014 Apr 22; 111(16):E1571-80. PMID: 24711390; PMCID: PMC4000801.
    15. Jiang X, Villafuerte MK, Andersson M, White SH, Kaback H. Galactoside-binding site in LacY. Biochemistry. 2014 Mar 11; 53(9):1536-43. PMID: 24520888; PMCID: PMC3985706.
    16. Madej MG, Sun L, Yan N, Kaback H. Functional architecture of MFS D-glucose transporters. Proc Natl Acad Sci U S A. 2014 Feb 18; 111(7):E719-27. PMID: 24550316; PMCID: PMC3932877.
    17. Kumar H, Kasho V, Smirnova I, Finer-Moore JS, Kaback H, Stroud RM. Structure of sugar-bound LacY. Proc Natl Acad Sci U S A. 2014 Feb 04; 111(5):1784-8. PMID: 24453216; PMCID: PMC3918835.
    18. Ethayathulla AS, Yousef MS, Amin A, Leblanc G, Kaback H, Guan L. Structure-based mechanism for Na(+)/melibiose symport by MelB. Nat Commun. 2014; 5:3009. PMID: 24389923; PMCID: PMC4026327.
    19. Madej MG, Kaback H. Evolutionary mix-and-match with MFS transporters II. Proc Natl Acad Sci U S A. 2013 Dec 10; 110(50):E4831-8. PMID: 24259711; PMCID: PMC3864288.
    20. Gaiko O, Bazzone A, Fendler K, Kaback H. Electrophysiological characterization of uncoupled mutants of LacY. Biochemistry. 2013 Nov 19; 52(46):8261-6. PMID: 24152072.
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    21. Jiang X, Driessen AJ, Feringa BL, Kaback H. The periplasmic cavity of LacY mutant Cys154?Gly: how open is open? Biochemistry. 2013 Sep 17; 52(37):6568-74. PMID: 23962108; PMCID: PMC3951333.
    22. Zhu L, Kaback H, Dalbey RE. YidC protein, a molecular chaperone for LacY protein folding via the SecYEG protein machinery. J Biol Chem. 2013 Sep 27; 288(39):28180-94. PMID: 23928306; PMCID: PMC3784728.
    23. Smirnova I, Kasho V, Sugihara J, Kaback H. Trp replacements for tightly interacting Gly-Gly pairs in LacY stabilize an outward-facing conformation. Proc Natl Acad Sci U S A. 2013 May 28; 110(22):8876-81. PMID: 23671103; PMCID: PMC3670396.
    24. Madej MG, Dang S, Yan N, Kaback H. Evolutionary mix-and-match with MFS transporters. Proc Natl Acad Sci U S A. 2013 Apr 09; 110(15):5870-4. PMID: 23530251; PMCID: PMC3625355.
    25. Smirnova I, Kasho V, Sugihara J, Vázquez-Ibar JL, Kaback H. Role of protons in sugar binding to LacY. Proc Natl Acad Sci U S A. 2012 Oct 16; 109(42):16835-40. PMID: 23033496; PMCID: PMC3479522.
    26. Madej MG, Soro SN, Kaback H. Apo-intermediate in the transport cycle of lactose permease (LacY). Proc Natl Acad Sci U S A. 2012 Oct 30; 109(44):E2970-8. PMID: 23012238; PMCID: PMC3497813.
    27. Andersson M, Bondar AN, Freites JA, Tobias DJ, Kaback H, White SH. Proton-coupled dynamics in lactose permease. Structure. 2012 Nov 07; 20(11):1893-904. PMID: 23000385; PMCID: PMC3496080.
    28. Sugihara J, Sun L, Yan N, Kaback H. Dynamics of the L-fucose/H+ symporter revealed by fluorescence spectroscopy. Proc Natl Acad Sci U S A. 2012 Sep 11; 109(37):14847-51. PMID: 22930818; PMCID: PMC3443143.
    29. Zhou Y, Jiang X, Kaback H. Role of the irreplaceable residues in the LacY alternating access mechanism. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12438-42. PMID: 22802658; PMCID: PMC3412042.
    30. Jiang X, Guan L, Zhou Y, Hong WX, Zhang Q, Kaback H. Evidence for an intermediate conformational state of LacY. Proc Natl Acad Sci U S A. 2012 Mar 20; 109(12):E698-704. PMID: 22355148; PMCID: PMC3311394.
    31. Sugihara J, Smirnova I, Kasho V, Kaback H. Sugar recognition by CscB and LacY. Biochemistry. 2011 Dec 27; 50(51):11009-14. PMID: 22106930; PMCID: PMC3249425.
    32. Smirnova I, Kasho V, Kaback H. Lactose permease and the alternating access mechanism. Biochemistry. 2011 Nov 15; 50(45):9684-93. PMID: 21995338; PMCID: PMC3210931.
    33. Smirnova I, Kasho V, Sugihara J, Kaback H. Opening the periplasmic cavity in lactose permease is the limiting step for sugar binding. Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37):15147-51. PMID: 21896727; PMCID: PMC3174601.
    34. Zhou Y, Madej MG, Guan L, Nie Y, Kaback H. An early event in the transport mechanism of LacY protein: interaction between helices V and I. J Biol Chem. 2011 Sep 02; 286(35):30415-22. PMID: 21730060; PMCID: PMC3162401.
    35. Chaptal V, Kwon S, Sawaya MR, Guan L, Kaback H, Abramson J. Crystal structure of lactose permease in complex with an affinity inactivator yields unique insight into sugar recognition. Proc Natl Acad Sci U S A. 2011 Jun 07; 108(23):9361-6. PMID: 21593407; PMCID: PMC3111295.
    36. Jiang X, Nie Y, Kaback H. Site-directed alkylation studies with LacY provide evidence for the alternating access model of transport. Biochemistry. 2011 Mar 15; 50(10):1634-40. PMID: 21254783; PMCID: PMC3057939.
    37. Kaback H, Smirnova I, Kasho V, Nie Y, Zhou Y. The alternating access transport mechanism in LacY. J Membr Biol. 2011 Jan; 239(1-2):85-93. PMID: 21161516; PMCID: PMC3030946.
    38. Garcia-Celma JJ, Ploch J, Smirnova I, Kaback H, Fendler K. Delineating electrogenic reactions during lactose/H+ symport. Biochemistry. 2010 Jul 27; 49(29):6115-21. PMID: 20568736; PMCID: PMC2907097.
    39. Nie Y, Kaback H. Sugar binding induces the same global conformational change in purified LacY as in the native bacterial membrane. Proc Natl Acad Sci U S A. 2010 May 25; 107(21):9903-8. PMID: 20457922; PMCID: PMC2906848.
    40. Liu Z, Madej MG, Kaback H. Helix dynamics in LacY: helices II and IV. J Mol Biol. 2010 Feb 26; 396(3):617-26. PMID: 20043916; PMCID: PMC3043081.
    41. Smirnova I, Kasho V, Sugihara J, Kaback H. Probing of the rates of alternating access in LacY with Trp fluorescence. Proc Natl Acad Sci U S A. 2009 Dec 22; 106(51):21561-6. PMID: 19959662; PMCID: PMC2799877.
    42. Guan L, Kaback H. Properties of a LacY efflux mutant. Biochemistry. 2009 Oct 06; 48(39):9250-5. PMID: 19719233; PMCID: PMC2754601.
    43. Zhou Y, Nie Y, Kaback H. Residues gating the periplasmic pathway of LacY. J Mol Biol. 2009 Nov 27; 394(2):219-25. PMID: 19781551; PMCID: PMC2784193.
    44. Smirnova I, Kasho V, Sugihara J, Choe JY, Kaback H. Residues in the H+ translocation site define the pKa for sugar binding to LacY. Biochemistry. 2009 Sep 22; 48(37):8852-60. PMID: 19689129; PMCID: PMC2769999.
    45. Garcia-Celma JJ, Smirnova IN, Kaback H, Fendler K. Electrophysiological characterization of LacY. Proc Natl Acad Sci U S A. 2009 May 05; 106(18):7373-8. PMID: 19383792; PMCID: PMC2671326.
    46. Nie Y, Zhou Y, Kaback H. Clogging the periplasmic pathway in LacY. Biochemistry. 2009 Feb 03; 48(4):738-43. PMID: 19128028; PMCID: PMC2654236.
    47. Smirnova IN, Kasho V, Kaback H. Protonation and sugar binding to LacY. Proc Natl Acad Sci U S A. 2008 Jul 01; 105(26):8896-901. PMID: 18567672; PMCID: PMC3021437.
    48. Nie Y, Sabetfard FE, Kaback H. The Cys154-->Gly mutation in LacY causes constitutive opening of the hydrophilic periplasmic pathway. J Mol Biol. 2008 Jun 13; 379(4):695-703. PMID: 18485365; PMCID: PMC2769995.
    49. Zhou Y, Guan L, Freites JA, Kaback H. Opening and closing of the periplasmic gate in lactose permease. Proc Natl Acad Sci U S A. 2008 Mar 11; 105(10):3774-8. PMID: 18319336; PMCID: PMC2268789.
    50. Smirnova I, Kasho V, Choe JY, Altenbach C, Hubbell WL, Kaback H. Sugar binding induces an outward facing conformation of LacY. Proc Natl Acad Sci U S A. 2007 Oct 16; 104(42):16504-9. PMID: 17925435; PMCID: PMC2034228.
    51. Guan L, Mirza O, Verner G, Iwata S, Kaback H. Structural determination of wild-type lactose permease. Proc Natl Acad Sci U S A. 2007 Sep 25; 104(39):15294-8. PMID: 17881559; PMCID: PMC2000551.
    52. Nie Y, Ermolova N, Kaback H. Site-directed alkylation of LacY: effect of the proton electrochemical gradient. J Mol Biol. 2007 Nov 23; 374(2):356-64. PMID: 17920075; PMCID: PMC2224895.
    53. Majumdar DS, Smirnova I, Kasho V, Nir E, Kong X, Weiss S, Kaback H. Single-molecule FRET reveals sugar-induced conformational dynamics in LacY. Proc Natl Acad Sci U S A. 2007 Jul 31; 104(31):12640-5. PMID: 17502603; PMCID: PMC1937519.
    54. Guan L, Kaback H. Site-directed alkylation of cysteine to test solvent accessibility of membrane proteins. Nat Protoc. 2007; 2(8):2012-7. PMID: 17703213; PMCID: PMC2775809.
    55. Kaback H, Dunten R, Frillingos S, Venkatesan P, Kwaw I, Zhang W, Ermolova N. Site-directed alkylation and the alternating access model for LacY. Proc Natl Acad Sci U S A. 2007 Jan 09; 104(2):491-4. PMID: 17172438; PMCID: PMC1766412.
    56. Smirnova IN, Kasho VN, Kaback H. Direct sugar binding to LacY measured by resonance energy transfer. Biochemistry. 2006 Dec 26; 45(51):15279-87. PMID: 17176050; PMCID: PMC2566955.
    57. Nie Y, Smirnova I, Kasho V, Kaback H. Energetics of ligand-induced conformational flexibility in the lactose permease of Escherichia coli. J Biol Chem. 2006 Nov 24; 281(47):35779-84. PMID: 17003033; PMCID: PMC2793331.
    58. Ermolova N, Madhvani RV, Kaback H. Site-directed alkylation of cysteine replacements in the lactose permease of Escherichia coli: helices I, III, VI, and XI. Biochemistry. 2006 Apr 04; 45(13):4182-9. PMID: 16566592.
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    59. Kasho VN, Smirnova IN, Kaback H. Sequence alignment and homology threading reveals prokaryotic and eukaryotic proteins similar to lactose permease. J Mol Biol. 2006 May 12; 358(4):1060-70. PMID: 16574153; PMCID: PMC2785551.
    60. Mirza O, Guan L, Verner G, Iwata S, Kaback H. Structural evidence for induced fit and a mechanism for sugar/H+ symport in LacY. EMBO J. 2006 Mar 22; 25(6):1177-83. PMID: 16525509; PMCID: PMC1422171.
    61. Vadyvaloo V, Smirnova IN, Kasho VN, Kaback H. Conservation of residues involved in sugar/H(+) symport by the sucrose permease of Escherichia coli relative to lactose permease. J Mol Biol. 2006 May 12; 358(4):1051-9. PMID: 16574149; PMCID: PMC2786776.
    62. Guan L, Smirnova IN, Verner G, Nagamori S, Nagamoni S, Kaback H. Manipulating phospholipids for crystallization of a membrane transport protein. Proc Natl Acad Sci U S A. 2006 Feb 07; 103(6):1723-6. PMID: 16446422; PMCID: PMC1413674.
    63. Guan L, Kaback H. Lessons from lactose permease. Annu Rev Biophys Biomol Struct. 2006; 35:67-91. PMID: 16689628; PMCID: PMC2802108.
    64. Kaback H. Structure and mechanism of the lactose permease. C R Biol. 2005 Jun; 328(6):557-67. PMID: 15950162.
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    65. Ermolova NV, Smirnova IN, Kasho VN, Kaback H. Interhelical packing modulates conformational flexibility in the lactose permease of Escherichia coli. Biochemistry. 2005 May 31; 44(21):7669-77. PMID: 15909981.
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    66. Weinglass AB, Soskine M, Vazquez-Ibar JL, Whitelegge JP, Faull KF, Kaback H, Schuldiner S. Exploring the role of a unique carboxyl residue in EmrE by mass spectrometry. J Biol Chem. 2005 Mar 04; 280(9):7487-92. PMID: 15623511.
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    67. Vázquez-Ibar JL, Guan L, Weinglass AB, Verner G, Gordillo R, Kaback H. Sugar recognition by the lactose permease of Escherichia coli. J Biol Chem. 2004 Nov 19; 279(47):49214-21. PMID: 15364943.
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    68. Weinglass AB, Whitelegge JP, Kaback H. Integrating mass spectrometry into membrane protein drug discovery. Curr Opin Drug Discov Devel. 2004 Sep; 7(5):589-99. PMID: 15503862.
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    69. Guan L, Kaback H. Binding affinity of lactose permease is not altered by the H+ electrochemical gradient. Proc Natl Acad Sci U S A. 2004 Aug 17; 101(33):12148-52. PMID: 15304639; PMCID: PMC514448.
    70. Abramson J, Kaback H, Iwata S. Structural comparison of lactose permease and the glycerol-3-phosphate antiporter: members of the major facilitator superfamily. Curr Opin Struct Biol. 2004 Aug; 14(4):413-9. PMID: 15313234.
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    71. Weinglass A, Whitelegge JP, Faull KF, Kaback H. Monitoring conformational rearrangements in the substrate-binding site of a membrane transport protein by mass spectrometry. J Biol Chem. 2004 Oct 01; 279(40):41858-65. PMID: 15272008.
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    72. Abramson J, Iwata S, Kaback H. Lactose permease as a paradigm for membrane transport proteins (Review). Mol Membr Biol. 2004 Jul-Aug; 21(4):227-36. PMID: 15371012.
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    73. Nagamori S, Smirnova IN, Kaback H. Role of YidC in folding of polytopic membrane proteins. J Cell Biol. 2004 Apr; 165(1):53-62. PMID: 15067017; PMCID: PMC2172087.
    74. Abramson J, Smirnova I, Kasho V, Verner G, Iwata S, Kaback H. The lactose permease of Escherichia coli: overall structure, the sugar-binding site and the alternating access model for transport. FEBS Lett. 2003 Nov 27; 555(1):96-101. PMID: 14630326.
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    75. Vázquez-Ibar JL, Guan L, Svrakic M, Kaback H. Exploiting luminescence spectroscopy to elucidate the interaction between sugar and a tryptophan residue in the lactose permease of Escherichia coli. Proc Natl Acad Sci U S A. 2003 Oct 28; 100(22):12706-11. PMID: 14566061; PMCID: PMC240682.
    76. Ermolova N, Guan L, Kaback H. Intermolecular thiol cross-linking via loops in the lactose permease of Escherichia coli. Proc Natl Acad Sci U S A. 2003 Sep 02; 100(18):10187-92. PMID: 12934015; PMCID: PMC193537.
    77. Sondej M, Vázquez-Ibar JL, Farshidi A, Peterkofsky A, Kaback H. Characterization of a lactose permease mutant that binds IIAGlc in the absence of ligand. Biochemistry. 2003 Aug 05; 42(30):9153-9. PMID: 12885249.
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    78. Abramson J, Smirnova I, Kasho V, Verner G, Kaback H, Iwata S. Structure and mechanism of the lactose permease of Escherichia coli. Science. 2003 Aug 01; 301(5633):610-5. PMID: 12893935.
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    79. Zhang W, Hu Y, Kaback H. Site-directed sulfhydryl labeling of helix IX in the lactose permease of Escherichia coli. Biochemistry. 2003 May 06; 42(17):4904-8. PMID: 12718531.
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    80. Weinglass AB, Whitelegge JP, Hu Y, Verner GE, Faull KF, Kaback H. Elucidation of substrate binding interactions in a membrane transport protein by mass spectrometry. EMBO J. 2003 Apr 01; 22(7):1467-77. PMID: 12660154; PMCID: PMC152890.
    81. Smirnova IN, Kaback H. A mutation in the lactose permease of Escherichia coli that decreases conformational flexibility and increases protein stability. Biochemistry. 2003 Mar 18; 42(10):3025-31. PMID: 12627968.
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    82. Guan L, Hu Y, Kaback H. Aromatic stacking in the sugar binding site of the lactose permease. Biochemistry. 2003 Feb 18; 42(6):1377-82. PMID: 12578349.
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    83. Nagamori S, Vázquez-Ibar JL, Weinglass AB, Kaback H. In vitro synthesis of lactose permease to probe the mechanism of membrane insertion and folding. J Biol Chem. 2003 Apr 25; 278(17):14820-6. PMID: 12590141.
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    84. Guan L, Sahin-Tóth M, Kálai T, Hideg K, Kaback H. Probing the mechanism of a membrane transport protein with affinity inactivators. J Biol Chem. 2003 Mar 21; 278(12):10641-8. PMID: 12471022.
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    85. Sahin-Tóth M, Gunawan P, Lawrence MC, Toyokuni T, Kaback H. Binding of hydrophobic D-galactopyranosides to the lactose permease of Escherichia coli. Biochemistry. 2002 Oct 29; 41(43):13039-45. PMID: 12390031.
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    86. Sorgen PL, Hu Y, Guan L, Kaback H, Girvin ME. An approach to membrane protein structure without crystals. Proc Natl Acad Sci U S A. 2002 Oct 29; 99(22):14037-40. PMID: 12391320; PMCID: PMC137832.
    87. Guan L, Sahin-Toth M, Kaback H. Changing the lactose permease of Escherichia coli into a galactose-specific symporter. Proc Natl Acad Sci U S A. 2002 May 14; 99(10):6613-8. PMID: 12011425; PMCID: PMC124451.
    88. Sondej M, Weinglass AB, Peterkofsky A, Kaback H. Binding of enzyme IIAGlc, a component of the phosphoenolpyruvate:sugar phosphotransferase system, to the Escherichia coli lactose permease. Biochemistry. 2002 Apr 30; 41(17):5556-65. PMID: 11969416.
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    89. Guan L, Murphy FD, Kaback H. Surface-exposed positions in the transmembrane helices of the lactose permease of Escherichia coli determined by intermolecular thiol cross-linking. Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):3475-80. PMID: 11904412; PMCID: PMC122548.
    90. Vázquez-Ibar JL, Weinglass AB, Kaback H. Engineering a terbium-binding site into an integral membrane protein for luminescence energy transfer. Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):3487-92. PMID: 11891311; PMCID: PMC122550.
    91. Weinglass AB, Sondej M, Kaback H. Manipulating conformational equilibria in the lactose permease of Escherichia coli. J Mol Biol. 2002 Jan 25; 315(4):561-71. PMID: 11812130.
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    92. Zhang W, Guan L, Kaback H. Helices VII and X in the lactose permease of Escherichia coli: proximity and ligand-induced distance changes. J Mol Biol. 2002 Jan 04; 315(1):53-62. PMID: 11771965.
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    93. Sahin-Tóth M, Lawrence MC, Nishio T, Kaback H. The C-4 hydroxyl group of galactopyranosides is the major determinant for ligand recognition by the lactose permease of Escherichia coli. Biochemistry. 2001 Oct 30; 40(43):13015-9. PMID: 11669639.
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    94. Guan L, Weinglass AB, Kaback H. Helix packing in the lactose permease of Escherichia coli: localization of helix VI. J Mol Biol. 2001 Sep 07; 312(1):69-77. PMID: 11545586.
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    95. Kwaw I, Zen KC, Hu Y, Kaback H. Site-directed sulfhydryl labeling of the lactose permease of Escherichia coli: helices IV and V that contain the major determinants for substrate binding. Biochemistry. 2001 Sep 04; 40(35):10491-9. PMID: 11523990.
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    96. Kaback H, Sahin-Tóth M, Weinglass AB. The kamikaze approach to membrane transport. Nat Rev Mol Cell Biol. 2001 Aug; 2(8):610-20. PMID: 11483994.
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    97. Sahin-Toth M, Kaback H. Arg-302 facilitates deprotonation of Glu-325 in the transport mechanism of the lactose permease from Escherichiacoli. Proc Natl Acad Sci U S A. 2001 May 22; 98(11):6068-73. PMID: 11353849; PMCID: PMC33423.
    98. Voss J, Wu J, Hubbell WL, Jacques V, Meares CF, Kaback H. Helix packing in the lactose permease of Escherichia coli: distances between site-directed nitroxides and a lanthanide. Biochemistry. 2001 Mar 13; 40(10):3184-8. PMID: 11258934.
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    99. Wolin CD, Kaback H. Functional estimation of loop-helix boundaries in the lactose permease of Escherichia coli by single amino acid deletion analysis. Biochemistry. 2001 Feb 20; 40(7):1996-2003. PMID: 11329266.
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    100. Weinglass AB, Smirnova IN, Kaback H. Engineering conformational flexibility in the lactose permease of Escherichia coli: use of glycine-scanning mutagenesis to rescue mutant Glu325-->Asp. Biochemistry. 2001 Jan 23; 40(3):769-76. PMID: 11170394.
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    101. Zhang W, Kaback H. Effect of the lipid phase transition on the lactose permease from Escherichia coli. Biochemistry. 2000 Nov 28; 39(47):14538-42. PMID: 11087408.
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    102. Sahin-Tóth M, Karlin A, Kaback H. Unraveling the mechanism of the lactose permease of Escherichia coli. Proc Natl Acad Sci U S A. 2000 Sep 26; 97(20):10729-32. PMID: 10984523; PMCID: PMC27091.
    103. Zhao M, Kálai T, Hideg K, Altenbach C, Hubbell WL, Kaback H. Binding of spin-labeled galactosides to the lactose permease of Escherichia coli. Biochemistry. 2000 Sep 19; 39(37):11381-8. PMID: 10985783.
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    104. Venkatesan P, Hu Y, Kaback H. Site-directed sulfhydryl labeling of the lactose permease of Escherichia coli: helix X. Biochemistry. 2000 Sep 05; 39(35):10656-61. PMID: 10978149.
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    105. Venkatesan P, Kwaw I, Hu Y, Kaback H. Site-directed sulfhydryl labeling of the lactose permease of Escherichia coli: helix VII. Biochemistry. 2000 Sep 05; 39(35):10641-8. PMID: 10978147.
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    106. Venkatesan P, Liu Z, Hu Y, Kaback H. Site-directed sulfhydryl labeling of the lactose permease of Escherichia coli: N-ethylmaleimide-sensitive face of helix II. Biochemistry. 2000 Sep 05; 39(35):10649-55. PMID: 10978148.
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    107. Weinglass AB, Kaback H. The central cytoplasmic loop of the major facilitator superfamily of transport proteins governs efficient membrane insertion. Proc Natl Acad Sci U S A. 2000 Aug 01; 97(16):8938-43. PMID: 10880570; PMCID: PMC16800.
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    215. Bibi E, Stearns SM, Kaback H. The N-terminal 22 amino acid residues in the lactose permease of Escherichia coli are not obligatory for membrane insertion or transport activity. Proc Natl Acad Sci U S A. 1992 Apr 15; 89(8):3180-4. PMID: 1565610; PMCID: PMC48829.
    216. McKenna E, Hardy D, Kaback H. Evidence that the final turn of the last transmembrane helix in the lactose permease is required for folding. J Biol Chem. 1992 Apr 05; 267(10):6471-4. PMID: 1551862.
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    217. Bibi E, Kaback H. Functional complementation of internal deletion mutants in the lactose permease of Escherichia coli. Proc Natl Acad Sci U S A. 1992 Mar 01; 89(5):1524-8. PMID: 1542643; PMCID: PMC48484.
    218. Kaback H. In and out and up and down with lac permease. Int Rev Cytol. 1992; 137:97-125. PMID: 1330966.
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    219. van Iwaarden PR, Pastore JC, Konings WN, Kaback H. Construction of a functional lactose permease devoid of cysteine residues. Biochemistry. 1991 Oct 08; 30(40):9595-600. PMID: 1911745.
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    220. van Iwaarden PR, Driessen AJ, Menick DR, Kaback H, Konings WN. Characterization of purified, reconstituted site-directed cysteine mutants of the lactose permease of Escherichia coli. J Biol Chem. 1991 Aug 25; 266(24):15688-92. PMID: 1874727.
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    221. Bibi E, Verner G, Chang CY, Kaback H. Organization and stability of a polytopic membrane protein: deletion analysis of the lactose permease of Escherichia coli. Proc Natl Acad Sci U S A. 1991 Aug 15; 88(16):7271-5. PMID: 1871132; PMCID: PMC52276.
    222. McKenna E, Hardy D, Pastore JC, Kaback H. Sequential truncation of the lactose permease over a three-amino acid sequence near the carboxyl terminus leads to progressive loss of activity and stability. Proc Natl Acad Sci U S A. 1991 Apr 15; 88(8):2969-73. PMID: 2014218; PMCID: PMC51365.
    223. Lolkema JS, Carrasco N, Kaback H. Kinetic analysis of lactose exchange in proteoliposomes reconstituted with purified lac permease. Biochemistry. 1991 Feb 05; 30(5):1284-90. PMID: 1991109.
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    224. Consler TG, Tsolas O, Kaback H. Role of proline residues in the structure and function of a membrane transport protein. Biochemistry. 1991 Feb 05; 30(5):1291-8. PMID: 1991110.
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    225. Hinkle PC, Hinkle PV, Kaback H. Information content of amino acid residues in putative helix VIII of the lac permease from Escherichia coli. Biochemistry. 1990 Dec 11; 29(49):10989-94. PMID: 2271693.
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    226. Kaback H, Bibi E, Roepe PD. Beta-galactoside transport in E. coli: a functional dissection of lac permease. Trends Biochem Sci. 1990 Aug; 15(8):309-14. PMID: 2204157.
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    227. Kaback H. The lac permease of Escherichia coli: a prototypic energy-transducing membrane protein. Biochim Biophys Acta. 1990 Jul 25; 1018(2-3):160-2. PMID: 2203471.
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    228. Bibi E, Kaback H. In vivo expression of the lacY gene in two segments leads to functional lac permease. Proc Natl Acad Sci U S A. 1990 Jun; 87(11):4325-9. PMID: 2190220; PMCID: PMC54102.
    229. Roepe PD, Consler TG, Menezes ME, Kaback H. The lac permease of Escherichia coli: site-directed mutagenesis studies on the mechanism of beta-galactoside/H+ symport. Res Microbiol. 1990 Mar-Apr; 141(3):290-308. PMID: 2177909.
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    230. Kaback H. Lac permease of Escherichia coli: on the path of the proton. Philos Trans R Soc Lond B Biol Sci. 1990 Jan 30; 326(1236):425-36. PMID: 1970647.
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    231. Pourcher T, Bassilana M, Sarkar HK, Kaback H, Leblanc G. Melibiose permease and alpha-galactosidase of Escherichia coli: identification by selective labeling using a T7 RNA polymerase/promoter expression system. Biochemistry. 1990 Jan 23; 29(3):690-6. PMID: 2159786.
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    232. Pourcher T, Sarkar HK, Bassilana M, Kaback H, Leblanc G. Histidine-94 is the only important histidine residue in the melibiose permease of Escherichia coli. Proc Natl Acad Sci U S A. 1990 Jan; 87(1):468-72. PMID: 2404282; PMCID: PMC53285.
    233. Roepe PD, Kaback H. Characterization and functional reconstitution of a soluble form of the hydrophobic membrane protein lac permease from Escherichia coli. Proc Natl Acad Sci U S A. 1989 Aug; 86(16):6087-91. PMID: 2668955; PMCID: PMC297780.
    234. Carrasco N, Püttner IB, Antes LM, Lee JA, Larigan JD, Lolkema JS, Roepe PD, Kaback H. Characterization of site-directed mutants in the lac permease of Escherichia coli. 2. Glutamate-325 replacements. Biochemistry. 1989 Mar 21; 28(6):2533-9. PMID: 2567181.
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    235. Lee JA, Püttner IB, Kaback H. Effect of distance and orientation between arginine-302, histidine-322, and glutamate-325 on the activity of lac permease from Escherichia coli. Biochemistry. 1989 Mar 21; 28(6):2540-4. PMID: 2567182.
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    236. Püttner IB, Sarkar HK, Padan E, Lolkema JS, Kaback H. Characterization of site-directed mutants in the lac permease of Escherichia coli. 1. Replacement of histidine residues. Biochemistry. 1989 Mar 21; 28(6):2525-33. PMID: 2659072.
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    237. Lolkema JS, Püttner IB, Kaback H. Site-directed mutagenesis of Pro327 in the lac permease of Escherichia coli. Biochemistry. 1988 Nov 01; 27(22):8307-10. PMID: 3072017.
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    238. Püttner IB, Kaback H. lac permease of Escherichia coli containing a single histidine residue is fully functional. Proc Natl Acad Sci U S A. 1988 Mar; 85(5):1467-71. PMID: 3278314; PMCID: PMC279792.
    239. Kaback H. Site-directed mutagenesis and ion-gradient driven active transport: on the path of the proton. Annu Rev Physiol. 1988; 50:243-56. PMID: 3288093.
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    240. Costello MJ, Escaig J, Matsushita K, Viitanen PV, Menick DR, Kaback H. Purified lac permease and cytochrome o oxidase are functional as monomers. J Biol Chem. 1987 Dec 15; 262(35):17072-82. PMID: 2824513.
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    241. Kaback H. Permease on parade: application of site-directed mutagenesis to ion-gradient driven active transport. Bioessays. 1987 Dec; 7(6):261-5. PMID: 3325054.
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    242. Menick DR, Carrasco N, Antes L, Patel L, Kaback H. lac permease of Escherichia coli: arginine-302 as a component of the postulated proton relay. Biochemistry. 1987 Oct 20; 26(21):6638-44. PMID: 2827732.
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    243. Kaback H. Use of site-directed mutagenesis to study the mechanism of a membrane transport protein. Biochemistry. 1987 Apr 21; 26(8):2071-6. PMID: 3304418.
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    244. Menick DR, Lee JA, Brooker RJ, Wilson TH, Kaback H. Role of cysteine residues in the lac permease of Escherichia coli. Biochemistry. 1987 Feb 24; 26(4):1132-6. PMID: 3552042.
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    245. Kaback H. Molecular biology of active transport: from membrane to molecule to mechanism. Harvey Lect. 1987-1988; 83:77-105. PMID: 3334141.
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    246. Püttner IB, Sarkar HK, Poonian MS, Kaback H. lac permease of Escherichia coli: histidine-205 and histidine-322 play different roles in lactose/H+ symport. Biochemistry. 1986 Aug 12; 25(16):4483-5. PMID: 3533138.
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    247. Carrasco N, Antes LM, Poonian MS, Kaback H. lac permease of Escherichia coli: histidine-322 and glutamic acid-325 may be components of a charge-relay system. Biochemistry. 1986 Aug 12; 25(16):4486-8. PMID: 2876725.
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    248. Sarkar HK, Menick DR, Viitanen PV, Poonian MS, Kaback H. Site-specific mutagenesis of cysteine 148 to serine in the lac permease of Escherichia coli. J Biol Chem. 1986 Jul 05; 261(19):8914-8. PMID: 3087982.
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    249. Sarkar HK, Viitanen PV, Poonian MS, Kaback H. Substitution of glutamine-60 with glutamic acid causes the lac permease of Escherichia coli to become temperature sensitive. Biochemistry. 1986 May 20; 25(10):2778-81. PMID: 2872916.
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    250. Kaback H. Active transport in Escherichia coli: passage to permease. Annu Rev Biophys Biophys Chem. 1986; 15:279-319. PMID: 3521656.
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    251. Carrasco N, Herzlinger D, Danho W, Kaback H. Preparation of monoclonal antibodies and site-directed polyclonal antibodies against the lac permease of Escherichia coli. Methods Enzymol. 1986; 125:453-67. PMID: 3520230.
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    252. Sarkar HK, Viitanen PV, Padan E, Trumble WR, Poonian MS, McComas W, Kaback H. Oligonucleotide-directed site-specific mutagenesis of the lac permease of Escherichia coli. Methods Enzymol. 1986; 125:214-30. PMID: 3520222.
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    253. Viitanen P, Newman MJ, Foster DL, Wilson TH, Kaback H. Purification, reconstitution, and characterization of the lac permease of Escherichia coli. Methods Enzymol. 1986; 125:429-52. PMID: 3520229.
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    254. Viitanen PV, Menick DR, Sarkar HK, Trumble WR, Kaback H. Site-directed mutagenesis of cysteine-148 in the lac permease of Escherichia coli: effect on transport, binding, and sulfhydryl inactivation. Biochemistry. 1985 Dec 17; 24(26):7628-35. PMID: 3912006.
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    255. Menick DR, Sarkar HK, Poonian MS, Kaback H. cys154 Is important for lac permease activity in Escherichia coli. Biochem Biophys Res Commun. 1985 Oct 15; 132(1):162-70. PMID: 2998353.
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    256. Padan E, Sarkar HK, Viitanen PV, Poonian MS, Kaback H. Site-specific mutagenesis of histidine residues in the lac permease of Escherichia coli. Proc Natl Acad Sci U S A. 1985 Oct; 82(20):6765-8. PMID: 3901007; PMCID: PMC390767.
    257. Carrasco N, Herzlinger D, Dechiara S, Danho W, Kaback H. Topology of the lac permease protein in the membrane of Escherichia coli. Ann N Y Acad Sci. 1985; 456:305-6. PMID: 3911839.
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    258. Viitanen PV, Sarkar HK, Menick D, Trumble WR, Padan E, McComas W, Poonian M, Kaback H. Site-directed mutagenesis of the lacY gene of Escherichia coli. Ann N Y Acad Sci. 1985; 456:307-8. PMID: 3911840.
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    259. Kaback H. Proton electrochemical gradients and active transport: the saga of lac permease. Ann N Y Acad Sci. 1985; 456:291-304. PMID: 3004294.
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    260. Herzlinger D, Carrasco N, Kaback H. Functional and immunochemical characterization of a mutant of Escherichia coli energy uncoupled for lactose transport. Biochemistry. 1985 Jan 01; 24(1):221-9. PMID: 3888256.
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    261. Kaback H. From membrane to molecule with the lac permease of Escherichia coli. Curr Top Cell Regul. 1985; 26:137-48. PMID: 3000693.
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    262. Costello MJ, Viitanen P, Carrasco N, Foster DL, Kaback H. Morphology of proteoliposomes reconstituted with purified lac carrier protein from Escherichia coli. J Biol Chem. 1984 Dec 25; 259(24):15579-86. PMID: 6392300.
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    263. Carrasco N, Herzlinger D, Mitchell R, DeChiara S, Danho W, Gabriel TF, Kaback H. Intramolecular dislocation of the COOH terminus of the lac carrier protein in reconstituted proteoliposomes. Proc Natl Acad Sci U S A. 1984 Aug; 81(15):4672-6. PMID: 6379649; PMCID: PMC391552.
    264. Carrasco N, Viitanen P, Herzlinger D, Kaback H. Monoclonal antibodies against the lac carrier protein from Escherichia coli. 1. Functional studies. Biochemistry. 1984 Jul 31; 23(16):3681-7. PMID: 6383471.
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    265. Herzlinger D, Viitanen P, Carrasco N, Kaback H. Monoclonal antibodies against the lac carrier protein from Escherichia coli. 2. Binding studies with membrane vesicles and proteoliposomes reconstituted with purified lac carrier protein. Biochemistry. 1984 Jul 31; 23(16):3688-93. PMID: 6206889.
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    266. Trumble WR, Viitanen PV, Sarkar HK, Poonian MS, Kaback H. Site-directed mutagenesis of cys148 in the lac carrier protein of Escherichia coli. Biochem Biophys Res Commun. 1984 Mar 30; 119(3):860-7. PMID: 6370251.
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    267. Viitanen P, Garcia ML, Kaback H. Purified reconstituted lac carrier protein from Escherichia coli is fully functional. Proc Natl Acad Sci U S A. 1984 Mar; 81(6):1629-33. PMID: 6324209; PMCID: PMC344971.
    268. Goldkorn T, Rimon G, Kempner ES, Kaback H. Functional molecular weight of the lac carrier protein from Escherichia coli as studied by radiation inactivation analysis. Proc Natl Acad Sci U S A. 1984 Feb; 81(4):1021-5. PMID: 6230670; PMCID: PMC344755.
    269. Kaback H, Carrasco N, Foster D, Garcia ML, Goldkorn T, Patel L, Viitanen P. The lac carrier protein from Escherichia coli. Soc Gen Physiol Ser. 1984; 38:323-30. PMID: 6364369.
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    270. Matsushita K, Patel L, Gennis RB, Kaback H. Reconstitution of active transport in proteoliposomes containing cytochrome o oxidase and lac carrier protein purified from Escherichia coli. Proc Natl Acad Sci U S A. 1983 Aug; 80(16):4889-93. PMID: 6308657; PMCID: PMC384152.
    271. Goldkorn T, Rimon G, Kaback H. Topology of the lac carrier protein in the membrane of Escherichia coli. Proc Natl Acad Sci U S A. 1983 Jun; 80(11):3322-6. PMID: 6344081; PMCID: PMC394034.
    272. Viitanen P, Garcia ML, Foster DL, Kaczorowski GJ, Kaback H. Mechanism of lactose translocation in proteoliposomes reconstituted with lac carrier protein purified from Escherichia coli. 2. Deuterium solvent isotope effects. Biochemistry. 1983 May 10; 22(10):2531-6. PMID: 6305403.
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    273. Garcia ML, Viitanen P, Foster DL, Kaback H. Mechanism of lactose translocation in proteoliposomes reconstituted with lac carrier protein purified from Escherichia coli. 1. Effect of pH and imposed membrane potential on efflux, exchange, and counterflow. Biochemistry. 1983 May 10; 22(10):2524-31. PMID: 6344920.
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    274. Foster DL, Boublik M, Kaback H. Structure of the lac carrier protein of Escherichia coli. J Biol Chem. 1983 Jan 10; 258(1):31-4. PMID: 6336750.
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    275. Kaback H. The lac carrier protein in Escherichia coli. J Membr Biol. 1983; 76(2):95-112. PMID: 6358502.
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    276. Patel L, Garcia ML, Kaback H. Direct measurement of lactose/proton symport in Escherichia coli membrane vesicles: further evidence for the involvement of histidine residue(s). Biochemistry. 1982 Nov 09; 21(23):5805-10. PMID: 6295442.
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    277. Garcia ML, Patel L, Padan E, Kaback H. Mechanism of lactose transport in Escherichia coli membrane vesicles: evidence for the involvement of histidine residue(s) in the response of the lac carrier to the proton electrochemical gradient. Biochemistry. 1982 Nov 09; 21(23):5800-5. PMID: 6295441.
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    278. Carrasco N, Tahara SM, Patel L, Goldkorn T, Kaback H. Preparation, characterization, and properties of monoclonal antibodies against the lac carrier protein from Escherichia coli. Proc Natl Acad Sci U S A. 1982 Nov; 79(22):6894-8. PMID: 6757923; PMCID: PMC347240.
    279. Foster DL, Garcia ML, Newman MJ, Patel L, Kaback H. Lactose-proton symport by purified lac carrier protein. Biochemistry. 1982 Oct 26; 21(22):5634-8. PMID: 6293552.
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    280. Newman MJ, Foster DL, Wilson TH, Kaback H. Purification and reconstitution of functional lactose carrier from Escherichia coli. J Biol Chem. 1981 Nov 25; 256(22):11804-8. PMID: 7028742.
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    281. Robertson DE, Kaczorowski GJ, Garcia ML, Kaback H. Active transport in membrane vesicles from Escherichia coli: the electrochemical proton gradient alters the distribution of the lac carrier between two different kinetic states. Biochemistry. 1980 Dec 09; 19(25):5692-702. PMID: 7006690.
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    282. Kaczorowski GJ, LeBlanc G, Kaback H. Specific labeling of the lac carrier protein in membrane vesicles of Escherichia coli by a photoaffinity reagent. Proc Natl Acad Sci U S A. 1980 Nov; 77(11):6319-23. PMID: 7005896; PMCID: PMC350275.
    283. Cohn DE, Kaback H. Mechanism of the melibiose porter in membrane vesicles of Escherichia coli. Biochemistry. 1980 Sep 02; 19(18):4237-43. PMID: 6998495.
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