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Herschman Harvey

Title(s)Distinguished Research Professor, Biological Chemistry
Phone(310) 825-8745
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    Other Positions
    Title(s)Ralph and Marjorie Crump Distinguished Professor Emeritus, Molecular & Medical Pharmacology


    Collapse Research 
    Collapse Research Activities and Funding
    Novel molecular imaging approaches to monitor gene and cell-based therapies
    NIH/NCI R01CA160770Sep 1, 2011 - Aug 31, 2014
    Role: Co-Principal Investigator
    The role of epidermal, fibroblast and endothelial cell COX-2 in skin cancer
    NIH/NCI R01CA123055Aug 1, 2007 - Jun 30, 2012
    Role: Principal Investigator
    The UCLA Center for In Vivo Imaging in Cancer Biology
    NIH/NCI P50CA086306May 1, 2000 - Aug 31, 2015
    Role: Principal Investigator
    Imaging Cox-2 Gene Expression in Inflammation and Tumors
    NIH/NCI R01CA084572Dec 17, 1999 - Aug 31, 2010
    Role: Principal Investigator
    Research Training in Pharmacological Sciences
    NIH/NIGMS T32GM008652Jul 1, 1998 - Jun 30, 2006
    Role: Principal Investigator
    Neurotrophic Factor &Neuronal Primary Responses Genes
    NIH/NINDS R01NS028660Aug 6, 1991 - Jul 31, 2006
    Role: Principal Investigator
    MOLECULAR MECHANISMS--SINGLE AND 2-STAGE TRANSFORMATION
    NIH/NCI R01CA042887Jul 1, 1986 - Jun 30, 1989
    Role: Principal Investigator
    INITIATION OF CELLULAR PROLIFERATION
    NIH/NIGMS R01GM024797Jan 1, 1978 - Dec 31, 1998
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Argus JP, Wilks MQ, Zhou QD, Hsieh WY, Khialeeva E, Hoi XP, Bui V, Xu S, Yu AK, Wang ES, Herschman HR, Williams KJ, Bensinger SJ. Development and Application of FASA, a Model for Quantifying Fatty Acid Metabolism Using Stable Isotope Labeling. Cell Rep. 2018 Dec 04; 25(10):2919-2934.e8. PMID: 30517876.
      View in: PubMed
    2. Xu S, Catapang A, Braas D, Stiles L, Doh HM, Lee JT, Graeber TG, Damoiseaux R, Shirihai O, Herschman HR. A precision therapeutic strategy for hexokinase 1-null, hexokinase 2-positive cancers. Cancer Metab. 2018; 6:7. PMID: 29988332.
      View in: PubMed
    3. Xu S, Catapang A, Doh HM, Bayley NA, Lee JT, Braas D, Graeber TG, Herschman HR. Hexokinase 2 is targetable for HK1 negative, HK2 positive tumors from a wide variety of tissues of origin. J Nucl Med. 2018 Jun 07. PMID: 29880505.
      View in: PubMed
    4. Lin MC, Chen SY, He PL, Herschman H, Li HJ. PGE2 /EP4 antagonism enhances tumor chemosensitivity by inducing extracellular vesicle-mediated clearance of cancer stem cells. Int J Cancer. 2018 09 15; 143(6):1440-1455. PMID: 29658109.
      View in: PubMed
    5. Kirkby NS, Sampaio W, Etelvino G, Alves DT, Anders KL, Temponi R, Shala F, Nair AS, Ahmetaj-Shala B, Jiao J, Herschman HR, Wang X, Wahli W, Santos RA, Mitchell JA. Cyclooxygenase-2 Selectively Controls Renal Blood Flow Through a Novel PPARß/d-Dependent Vasodilator Pathway. Hypertension. 2018 02; 71(2):297-305. PMID: 29295852.
      View in: PubMed
    6. Le TM, Poddar S, Capri JR, Abt ER, Kim W, Wei L, Uong NT, Cheng CM, Braas D, Nikanjam M, Rix P, Merkurjev D, Zaretsky J, Kornblum HI, Ribas A, Herschman HR, Whitelegge J, Faull KF, Donahue TR, Czernin J, Radu CG. ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways. Nat Commun. 2017 08 14; 8(1):241. PMID: 28808226.
      View in: PubMed
    7. Lebedev A, Jiao J, Lee J, Yang F, Allison N, Herschman H, Sadeghi S. Radiochemistry on electrodes: Synthesis of an 18F-labelled and in vivo stable COX-2 inhibitor. PLoS One. 2017; 12(5):e0176606. PMID: 28464017.
      View in: PubMed
    8. Lin MC, Chen SY, Tsai HM, He PL, Lin YC, Herschman H, Li HJ. PGE2 /EP4 Signaling Controls the Transfer of the Mammary Stem Cell State by Lipid Rafts in Extracellular Vesicles. Stem Cells. 2017 02; 35(2):425-444. PMID: 27506158.
      View in: PubMed
    9. Escuin-Ordinas H, Li S, Xie MW, Sun L, Hugo W, Huang RR, Jiao J, de-Faria FM, Realegeno S, Krystofinski P, Azhdam A, Komenan SM, Atefi M, Comin-Anduix B, Pellegrini M, Cochran AJ, Modlin RL, Herschman HR, Lo RS, McBride WH, Segura T, Ribas A. Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors. Nat Commun. 2016 08 01; 7:12348. PMID: 27476449.
      View in: PubMed
    10. Kim W, Le TM, Wei L, Poddar S, Bazzy J, Wang X, Uong NT, Abt ER, Capri JR, Austin WR, Van Valkenburgh JS, Steele D, Gipson RM, Slavik R, Cabebe AE, Taechariyakul T, Yaghoubi SS, Lee JT, Sadeghi S, Lavie A, Faull KF, Witte ON, Donahue TR, Phelps ME, Herschman HR, Herrmann K, Czernin J, Radu CG. [18F]CFA as a clinically translatable probe for PET imaging of deoxycytidine kinase activity. Proc Natl Acad Sci U S A. 2016 Apr 12; 113(15):4027-32. PMID: 27035974; PMCID: PMC4839461 [Available on 10/12/16].
    11. Kirkby NS, Chan MV, Zaiss AK, Garcia-Vaz E, Jiao J, Berglund LM, Verdu EF, Ahmetaj-Shala B, Wallace JL, Herschman HR, Gomez MF, Mitchell JA. Systematic study of constitutive cyclooxygenase-2 expression: Role of NF-?B and NFAT transcriptional pathways. Proc Natl Acad Sci U S A. 2016 Jan 12; 113(2):434-9. PMID: 26712011; PMCID: PMC4720301.
    12. Zaiss AK, Foley EM, Lawrence R, Schneider LS, Hoveida H, Secrest P, Catapang AB, Yamaguchi Y, Alemany R, Shayakhmetov DM, Esko JD, Herschman HR. Hepatocyte Heparan Sulfate Is Required for Adeno-Associated Virus 2 but Dispensable for Adenovirus 5 Liver Transduction In Vivo. J Virol. 2016 01 01; 90(1):412-20. PMID: 26491162.
      View in: PubMed
    13. Martinez L, Ermolova NV, Ishikawa TO, Stout DB, Herschman HR, Spencer MJ. A reporter mouse for optical imaging of inflammation in mdx muscles. Skelet Muscle. 2015; 5:15. PMID: 25949789; PMCID: PMC4422315.
    14. Cherukuri DP, Deignan JL, Das K, Grody WW, Herschman H. Instability of a dinucleotide repeat in the 3'-untranslated region (UTR) of the microsomal prostaglandin E synthase-1 (mPGES-1) gene in microsatellite instability-high (MSI-H) colorectal carcinoma. Mol Oncol. 2015 Aug; 9(7):1252-8. PMID: 25817443; PMCID: PMC4523444.
    15. Roulis M, Nikolaou C, Kotsaki E, Kaffe E, Karagianni N, Koliaraki V, Salpea K, Ragoussis J, Aidinis V, Martini E, Becker C, Herschman HR, Vetrano S, Danese S, Kollias G. Intestinal myofibroblast-specific Tpl2-Cox-2-PGE2 pathway links innate sensing to epithelial homeostasis. Proc Natl Acad Sci U S A. 2014 Oct 28; 111(43):E4658-67. PMID: 25316791; PMCID: PMC4217397.
    16. Vadivel K, Ponnuraj SM, Kumar Y, Zaiss AK, Bunce MW, Camire RM, Wu L, Evseenko D, Herschman HR, Bajaj MS, Bajaj SP. Platelets contain tissue factor pathway inhibitor-2 derived from megakaryocytes and inhibits fibrinolysis. J Biol Chem. 2014 Nov 07; 289(45):31647-61. PMID: 25262870; PMCID: PMC4223360.
    17. Wilhelms DB, Kirilov M, Mirrasekhian E, Eskilsson A, Kugelberg UÖ, Klar C, Ridder DA, Herschman HR, Schwaninger M, Blomqvist A, Engblom D. Deletion of prostaglandin E2 synthesizing enzymes in brain endothelial cells attenuates inflammatory fever. J Neurosci. 2014 Aug 27; 34(35):11684-90. PMID: 25164664.
      View in: PubMed
    18. Zadran S, Arumugam R, Herschman H, Phelps ME, Levine RD. Surprisal analysis characterizes the free energy time course of cancer cells undergoing epithelial-to-mesenchymal transition. Proc Natl Acad Sci U S A. 2014 Sep 09; 111(36):13235-40. PMID: 25157127; PMCID: PMC4246928.
    19. Jiao J, Ishikawa TO, Dumlao DS, Norris PC, Magyar CE, Mikulec C, Catapang A, Dennis EA, Fischer SM, Herschman HR. Targeted deletion and lipidomic analysis identify epithelial cell COX-2 as a major driver of chemically induced skin cancer. Mol Cancer Res. 2014 Nov; 12(11):1677-88. PMID: 25063587; PMCID: PMC4233191.
    20. Huang C, Xue M, Chen H, Jiao J, Herschman HR, O'Keefe RJ, Zhang X. The spatiotemporal role of COX-2 in osteogenic and chondrogenic differentiation of periosteum-derived mesenchymal progenitors in fracture repair. PLoS One. 2014; 9(7):e100079. PMID: 24988184; PMCID: PMC4079554.
    21. Zaiss AK, Zuber J, Chu C, Machado HB, Jiao J, Catapang AB, Ishikawa TO, Gil JS, Lowe SW, Herschman HR. Reversible suppression of cyclooxygenase 2 (COX-2) expression in vivo by inducible RNA interference. PLoS One. 2014; 9(7):e101263. PMID: 24988319; PMCID: PMC4079684.
    22. An Y, Belevych N, Wang Y, Zhang H, Nasse JS, Herschman H, Chen Q, Tarr A, Liu X, Quan N. Prostacyclin mediates endothelial COX-2-dependent neuroprotective effects during excitotoxic brain injury. J Inflamm Res. 2014; 7:57-67. PMID: 24971026; PMCID: PMC4070856.
    23. Duarte S, Kato H, Kuriyama N, Suko K, Ishikawa TO, Busuttil RW, Herschman HR, Coito AJ. Hepatic ischemia and reperfusion injury in the absence of myeloid cell-derived COX-2 in mice. PLoS One. 2014; 9(5):e96913. PMID: 24819536; PMCID: PMC4018446.
    24. Mongini PK, Kramer JM, Ishikawa TO, Herschman H, Esposito D. Candidate chromosome 1 disease susceptibility genes for Sjogren's syndrome xerostomia are narrowed by novel NOD.B10 congenic mice. Clin Immunol. 2014 Jul; 153(1):79-90. PMID: 24685748; PMCID: PMC4058348.
    25. Nathanson DA, Armijo AL, Tom M, Li Z, Dimitrova E, Austin WR, Nomme J, Campbell DO, Ta L, Le TM, Lee JT, Darvish R, Gordin A, Wei L, Liao HI, Wilks M, Martin C, Sadeghi S, Murphy JM, Boulos N, Phelps ME, Faull KF, Herschman HR, Jung ME, Czernin J, Lavie A, Radu CG. Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication. J Exp Med. 2014 Mar 10; 211(3):473-86. PMID: 24567448; PMCID: PMC3949575.
    26. Jiao J, Mikulec C, Ishikawa TO, Magyar C, Dumlao DS, Dennis EA, Fischer SM, Herschman H. Cell-type-specific roles for COX-2 in UVB-induced skin cancer. Carcinogenesis. 2014 Jun; 35(6):1310-9. PMID: 24469308; PMCID: PMC4043244.
    27. An Y, Belevych N, Wang Y, Zhang H, Herschman H, Chen Q, Quan N. Neuronal and nonneuronal COX-2 expression confers neurotoxic and neuroprotective phenotypes in response to excitotoxin challenge. J Neurosci Res. 2014 Apr; 92(4):486-95. PMID: 24375716; PMCID: PMC4085774.
    28. Escuin-Ordinas H, Atefi M, Fu Y, Cass A, Ng C, Huang RR, Yashar S, Comin-Anduix B, Avramis E, Cochran AJ, Marais R, Lo RS, Graeber TG, Herschman HR, Ribas A. COX-2 inhibition prevents the appearance of cutaneous squamous cell carcinomas accelerated by BRAF inhibitors. Mol Oncol. 2014 Mar; 8(2):250-60. PMID: 24345644; PMCID: PMC3943738.
    29. Cherukuri DP, Ishikawa TO, Chun P, Catapang A, Elashoff D, Grogan TR, Bugni J, Herschman HR. Targeted Cox2 gene deletion in intestinal epithelial cells decreases tumorigenesis in female, but not male, ApcMin/+ mice. Mol Oncol. 2014 Mar; 8(2):169-77. PMID: 24268915; PMCID: PMC3963510.
    30. Murphy JM, Armijo AL, Nomme J, Lee CH, Smith QA, Li Z, Campbell DO, Liao HI, Nathanson DA, Austin WR, Lee JT, Darvish R, Wei L, Wang J, Su Y, Damoiseaux R, Sadeghi S, Phelps ME, Herschman HR, Czernin J, Alexandrova AN, Jung ME, Lavie A, Radu CG. Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography. J Med Chem. 2013 Sep 12; 56(17):6696-708. PMID: 23947754; PMCID: PMC3789385.
    31. Kirkby NS, Zaiss AK, Wright WR, Jiao J, Chan MV, Warner TD, Herschman HR, Mitchell JA. Differential COX-2 induction by viral and bacterial PAMPs: Consequences for cytokine and interferon responses and implications for anti-viral COX-2 directed therapies. Biochem Biophys Res Commun. 2013 Aug 23; 438(2):249-56. PMID: 23850620; PMCID: PMC3759847.
    32. Kirkby NS, Zaiss AK, Urquhart P, Jiao J, Austin PJ, Al-Yamani M, Lundberg MH, MacKenzie LS, Warner TD, Nicolaou A, Herschman HR, Mitchell JA. LC-MS/MS confirms that COX-1 drives vascular prostacyclin whilst gene expression pattern reveals non-vascular sites of COX-2 expression. PLoS One. 2013; 8(7):e69524. PMID: 23874970; PMCID: PMC3711559.
    33. Gil JS, Machado HB, Campbell DO, McCracken M, Radu C, Witte ON, Herschman HR. Application of a rapid, simple, and accurate adenovirus-based method to compare PET reporter gene/PET reporter probe systems. Mol Imaging Biol. 2013 Jun; 15(3):273-81. PMID: 23054556; PMCID: PMC3833443.
    34. Austin WR, Armijo AL, Campbell DO, Singh AS, Hsieh T, Nathanson D, Herschman HR, Phelps ME, Witte ON, Czernin J, Radu CG. Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress. J Exp Med. 2012 Nov 19; 209(12):2215-28. PMID: 23148236; PMCID: PMC3501349.
    35. Gil JS, Machado HB, Herschman HR. A method to rapidly and accurately compare the relative efficacies of non-invasive imaging reporter genes in a mouse model and its application to luciferase reporters. Mol Imaging Biol. 2012 Aug; 14(4):462-71. PMID: 21850545; PMCID: PMC3813453.
    36. Hill R, Li Y, Tran LM, Dry S, Calvopina JH, Garcia A, Kim C, Wang Y, Donahue TR, Herschman HR, Wu H. Cell intrinsic role of COX-2 in pancreatic cancer development. Mol Cancer Ther. 2012 Oct; 11(10):2127-37. PMID: 22784710; PMCID: PMC3469770.
    37. Li HJ, Reinhardt F, Herschman HR, Weinberg RA. Cancer-stimulated mesenchymal stem cells create a carcinoma stem cell niche via prostaglandin E2 signaling. Cancer Discov. 2012 Sep; 2(9):840-55. PMID: 22763855; PMCID: PMC3833451.
    38. Herschman HR, Czernin J. A spotlight from prostate cancer. Cancer Discov. 2012 Apr; 2(4):301-3. PMID: 22576205.
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    39. Campbell DO, Yaghoubi SS, Su Y, Lee JT, Auerbach MS, Herschman H, Satyamurthy N, Czernin J, Lavie A, Radu CG. Structure-guided engineering of human thymidine kinase 2 as a positron emission tomography reporter gene for enhanced phosphorylation of non-natural thymidine analog reporter probe. J Biol Chem. 2012 Jan 02; 287(1):446-54. PMID: 22074768; PMCID: PMC3249097.
    40. Zaiss AK, Lawrence R, Elashoff D, Esko JD, Herschman HR. Differential effects of murine and human factor X on adenovirus transduction via cell-surface heparan sulfate. J Biol Chem. 2011 Jul 15; 286(28):24535-43. PMID: 21596747; PMCID: PMC3137028.
    41. Ishikawa TO, Herschman HR. Conditional bicistronic Cre reporter line expressing both firefly luciferase and ß-galactosidase. Mol Imaging Biol. 2011 Apr; 13(2):284-92. PMID: 20495880; PMCID: PMC3051074.
    42. Lu Y, Machado HB, Bao Q, Stout D, Herschman H, Chatziioannou AF. In vivo mouse bioluminescence tomography with radionuclide-based imaging validation. Mol Imaging Biol. 2011 Feb; 13(1):53-8. PMID: 20464517; PMCID: PMC3023015.
    43. Ishikawa TO, Oshima M, Herschman HR. Cox-2 deletion in myeloid and endothelial cells, but not in epithelial cells, exacerbates murine colitis. Carcinogenesis. 2011 Mar; 32(3):417-26. PMID: 21156970; PMCID: PMC3047239.
    44. Zhang W, Kater AP, Widhopf GF, Chuang HY, Enzler T, James DF, Poustovoitov M, Tseng PH, Janz S, Hoh C, Herschman H, Karin M, Kipps TJ. B-cell activating factor and v-Myc myelocytomatosis viral oncogene homolog (c-Myc) influence progression of chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 2010 Nov 02; 107(44):18956-60. PMID: 20956327; PMCID: PMC2973856.
    45. Tseng HC, Arasteh A, Paranjpe A, Teruel A, Yang W, Behel A, Alva JA, Walter G, Head C, Ishikawa TO, Herschman HR, Cacalano N, Pyle AD, Park NH, Jewett A. Increased lysis of stem cells but not their differentiated cells by natural killer cells; de-differentiation or reprogramming activates NK cells. PLoS One. 2010 Jul 16; 5(7):e11590. PMID: 20661281; PMCID: PMC2905395.
    46. Ishikawa TO, Jain NK, Herschman HR. Cox-2 gene expression in chemically induced skin papillomas cannot predict subsequent tumor fate. Mol Oncol. 2010 Aug; 4(4):347-56. PMID: 20599447; PMCID: PMC2917485.
    47. Papanicolaou KN, Streicher JM, Ishikawa TO, Herschman H, Wang Y, Walsh K. Preserved heart function and maintained response to cardiac stresses in a genetic model of cardiomyocyte-targeted deficiency of cyclooxygenase-2. J Mol Cell Cardiol. 2010 Aug; 49(2):196-209. PMID: 20399788; PMCID: PMC2891277.
    48. Huang H, Chikazu D, Voznesensky OS, Herschman HR, Kream BE, Drissi H, Pilbeam CC. Parathyroid hormone induction of cyclooxygenase-2 in murine osteoblasts: role of the calcium-calcineurin-NFAT pathway. J Bone Miner Res. 2010 Apr; 25(4):819-29. PMID: 19821778; PMCID: PMC3153333.
    49. Streicher JM, Ren S, Herschman H, Wang Y. MAPK-activated protein kinase-2 in cardiac hypertrophy and cyclooxygenase-2 regulation in heart. Circ Res. 2010 Apr 30; 106(8):1434-43. PMID: 20339119; PMCID: PMC2903446.
    50. Watanabe J, Lin JA, Narasimha AJ, Shahbazian A, Ishikawa TO, Martin MG, Herschman HR, Reddy ST. Novel anti-inflammatory functions for endothelial and myeloid cyclooxygenase-2 in a new mouse model of Crohn's disease. Am J Physiol Gastrointest Liver Physiol. 2010 Jun; 298(6):G842-50. PMID: 20299600.
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    51. Streicher JM, Kamei K, Ishikawa TO, Herschman H, Wang Y. Compensatory hypertrophy induced by ventricular cardiomyocyte-specific COX-2 expression in mice. J Mol Cell Cardiol. 2010 Jul; 49(1):88-94. PMID: 20170663; PMCID: PMC2883637.
    52. Ishikawa TO, Kumar IP, Machado HB, Wong KP, Kusewitt D, Huang SC, Fischer SM, Herschman HR. Positron emission tomography imaging of DMBA/TPA mouse skin multi-step tumorigenesis. Mol Oncol. 2010 Apr; 4(2):119-25. PMID: 20171942; PMCID: PMC2838935.
    53. Ishikawa TO, Herschman HR. Tumor formation in a mouse model of colitis-associated colon cancer does not require COX-1 or COX-2 expression. Carcinogenesis. 2010 Apr; 31(4):729-36. PMID: 20061361; PMCID: PMC2847091.
    54. Toy G, Austin WR, Liao HI, Cheng D, Singh A, Campbell DO, Ishikawa TO, Lehmann LW, Satyamurthy N, Phelps ME, Herschman HR, Czernin J, Witte ON, Radu CG. Requirement for deoxycytidine kinase in T and B lymphocyte development. Proc Natl Acad Sci U S A. 2010 Mar 23; 107(12):5551-6. PMID: 20080663; PMCID: PMC2851816.
    55. Johnson SL, Franz C, Kuhn S, Furness DN, Rüttiger L, Münkner S, Rivolta MN, Seward EP, Herschman HR, Engel J, Knipper M, Marcotti W. Synaptotagmin IV determines the linear Ca2+ dependence of vesicle fusion at auditory ribbon synapses. Nat Neurosci. 2010 Jan; 13(1):45-52. PMID: 20010821.
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    56. Lomenick B, Hao R, Jonai N, Chin RM, Aghajan M, Warburton S, Wang J, Wu RP, Gomez F, Loo JA, Wohlschlegel JA, Vondriska TM, Pelletier J, Herschman HR, Clardy J, Clarke CF, Huang J. Target identification using drug affinity responsive target stability (DARTS). Proc Natl Acad Sci U S A. 2009 Dec 22; 106(51):21984-9. PMID: 19995983.
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    57. Narasimha AJ, Watanabe J, Ishikawa TO, Priceman SJ, Wu L, Herschman HR, Reddy ST. Absence of myeloid COX-2 attenuates acute inflammation but does not influence development of atherosclerosis in apolipoprotein E null mice. Arterioscler Thromb Vasc Biol. 2010 Feb; 30(2):260-8. PMID: 19926832; PMCID: PMC2859183.
    58. Zaiss AK, Machado HB, Herschman HR. The influence of innate and pre-existing immunity on adenovirus therapy. J Cell Biochem. 2009 Nov 01; 108(4):778-90. PMID: 19711370; PMCID: PMC2822460.
    59. Lu Y, Douraghy A, Machado HB, Stout D, Tian J, Herschman H, Chatziioannou AF. Spectrally resolved bioluminescence tomography with the third-order simplified spherical harmonics approximation. Phys Med Biol. 2009 Nov 07; 54(21):6477-93. PMID: 19820264; PMCID: PMC2791679.
    60. Lu Y, Machado HB, Douraghy A, Stout D, Herschman H, Chatziioannou AF. Experimental bioluminescence tomography with fully parallel radiative-transfer-based reconstruction framework. Opt Express. 2009 Sep 14; 17(19):16681-95. PMID: 19770883; PMCID: PMC2790868.
    61. Ohashi K, Ouchi N, Sato K, Higuchi A, Ishikawa TO, Herschman HR, Kihara S, Walsh K. Adiponectin promotes revascularization of ischemic muscle through a cyclooxygenase 2-dependent mechanism. Mol Cell Biol. 2009 Jul; 29(13):3487-99. PMID: 19398582; PMCID: PMC2698754.
    62. Laing RE, Walter MA, Campbell DO, Herschman HR, Satyamurthy N, Phelps ME, Czernin J, Witte ON, Radu CG. Noninvasive prediction of tumor responses to gemcitabine using positron emission tomography. Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8):2847-52. PMID: 19196993; PMCID: PMC2636738.
    63. Li HJ, Everts M, Yamamoto M, Curiel DT, Herschman HR. Combined transductional untargeting/retargeting and transcriptional restriction enhances adenovirus gene targeting and therapy for hepatic colorectal cancer tumors. Cancer Res. 2009 Jan 15; 69(2):554-64. PMID: 19147569; PMCID: PMC2823090.
    64. Ishikawa TO, Jain N, Herschman HR. Feedback regulation of cyclooxygenase-2 transcription ex vivo and in vivo. Biochem Biophys Res Commun. 2009 Jan 16; 378(3):534-8. PMID: 19061862; PMCID: PMC2637547.
    65. Jain NK, Ishikawa TO, Spigelman I, Herschman HR. COX-2 expression and function in the hyperalgesic response to paw inflammation in mice. Prostaglandins Leukot Essent Fatty Acids. 2008 Dec; 79(6):183-90. PMID: 18829279; PMCID: PMC2615797.
    66. Kenanova V, Barat B, Olafsen T, Chatziioannou A, Herschman HR, Braun J, Wu AM. Recombinant carcinoembryonic antigen as a reporter gene for molecular imaging. Eur J Nucl Med Mol Imaging. 2009 Jan; 36(1):104-14. PMID: 18719907; PMCID: PMC2803699.
    67. Machado HB, Vician LJ, Herschman HR. The MAPK pathway is required for depolarization-induced "promiscuous" immediate-early gene expression but not for depolarization-restricted immediate-early gene expression in neurons. J Neurosci Res. 2008 Feb 15; 86(3):593-602. PMID: 17941051.
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    68. Weber WA, Czernin J, Phelps ME, Herschman HR. Technology Insight: novel imaging of molecular targets is an emerging area crucial to the development of targeted drugs. Nat Clin Pract Oncol. 2008 Jan; 5(1):44-54. PMID: 18097456; PMCID: PMC2830564.
    69. Ishikawa TO, Herschman HR. Two inducible, functional cyclooxygenase-2 genes are present in the rainbow trout genome. J Cell Biochem. 2007 Dec 15; 102(6):1486-92. PMID: 17471498.
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    70. Su F, Kozak KR, Herschman H, Reddy ST, Farias-Eisner R. Characterization of the rat urokinase plasminogen activator receptor promoter in PC12 cells. J Neurosci Res. 2007 Jul; 85(9):1952-8. PMID: 17455298.
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    71. Li HJ, Everts M, Pereboeva L, Komarova S, Idan A, Curiel DT, Herschman HR. Adenovirus tumor targeting and hepatic untargeting by a coxsackie/adenovirus receptor ectodomain anti-carcinoembryonic antigen bispecific adapter. Cancer Res. 2007 Jun 01; 67(11):5354-61. PMID: 17545616.
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    72. Sui G, Lee CC, Kamei K, Li HJ, Wang JY, Wang J, Herschman HR, Tseng HR. A microfluidic platform for sequential ligand labeling and cell binding analysis. Biomed Microdevices. 2007 Jun; 9(3):301-5. PMID: 17195108.
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    73. Koya RC, Kimura T, Ribas A, Rozengurt N, Lawson GW, Faure-Kumar E, Wang HJ, Herschman H, Kasahara N, Stripecke R. Lentiviral vector-mediated autonomous differentiation of mouse bone marrow cells into immunologically potent dendritic cell vaccines. Mol Ther. 2007 May; 15(5):971-80. PMID: 17375074.
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    74. Ishikawa TO, Griffin KJ, Banerjee U, Herschman HR. The zebrafish genome contains two inducible, functional cyclooxygenase-2 genes. Biochem Biophys Res Commun. 2007 Jan 05; 352(1):181-7. PMID: 17112475; PMCID: PMC1764854.
    75. Su H, Bodenstein C, Dumont RA, Seimbille Y, Dubinett S, Phelps ME, Herschman H, Czernin J, Weber W. Monitoring tumor glucose utilization by positron emission tomography for the prediction of treatment response to epidermal growth factor receptor kinase inhibitors. Clin Cancer Res. 2006 Oct 01; 12(19):5659-67. PMID: 17020967.
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    76. Xu Z, Choudhary S, Voznesensky O, Mehrotra M, Woodard M, Hansen M, Herschman H, Pilbeam C. Overexpression of COX-2 in human osteosarcoma cells decreases proliferation and increases apoptosis. Cancer Res. 2006 Jul 01; 66(13):6657-64. PMID: 16818639.
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    77. Ishikawa TO, Jain NK, Taketo MM, Herschman HR. Imaging cyclooxygenase-2 (Cox-2) gene expression in living animals with a luciferase knock-in reporter gene. Mol Imaging Biol. 2006 May-Jun; 8(3):171-87. PMID: 16557423.
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    78. Kamei K, Ishikawa TO, Herschman HR. Transgenic mouse for conditional, tissue-specific Cox-2 overexpression. Genesis. 2006 Apr; 44(4):177-82. PMID: 16604526.
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    79. Ishikawa TO, Herschman HR. Conditional knockout mouse for tissue-specific disruption of the cyclooxygenase-2 (Cox-2) gene. Genesis. 2006 Mar; 44(3):143-9. PMID: 16496341.
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    80. Czernin J, Weber WA, Herschman HR. Molecular imaging in the development of cancer therapeutics. Annu Rev Med. 2006; 57:99-118. PMID: 16409139.
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    81. Lu G, Kang YJ, Han J, Herschman HR, Stefani E, Wang Y. TAB-1 modulates intracellular localization of p38 MAP kinase and downstream signaling. J Biol Chem. 2006 Mar 03; 281(9):6087-95. PMID: 16407200.
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    82. Toyokuni T, Kumar JS, Walsh JC, Shapiro A, Talley JJ, Phelps ME, Herschman HR, Barrio JR, Satyamurthy N. Synthesis of 4-(5-[18F]fluoromethyl-3-phenylisoxazol-4-yl)benzenesulfonamide, a new [18F]fluorinated analogue of valdecoxib, as a potential radiotracer for imaging cyclooxygenase-2 with positron emission tomography. Bioorg Med Chem Lett. 2005 Nov 01; 15(21):4699-702. PMID: 16153836.
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    83. Chikazu D, Li X, Kawaguchi H, Sakuma Y, Voznesensky OS, Adams DJ, Xu M, Hoshi K, Katavic V, Herschman HR, Raisz LG, Pilbeam CC. Bone morphogenetic protein 2 induces cyclo-oxygenase 2 in osteoblasts via a Cbfa1 binding site: role in effects of bone morphogenetic protein 2 in vitro and in vivo. 2002. J Bone Miner Res. 2005 Oct; 20(10):1888-98. PMID: 16355502.
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    84. Yaghoubi SS, Barrio JR, Namavari M, Satyamurthy N, Phelps ME, Herschman HR, Gambhir SS. Imaging progress of herpes simplex virus type 1 thymidine kinase suicide gene therapy in living subjects with positron emission tomography. Cancer Gene Ther. 2005 Mar; 12(3):329-39. PMID: 15592447.
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    85. Liang Q, Dmitriev I, Kashentseva E, Curiel DT, Herschman HR. Noninvasive of adenovirus tumor retargeting in living subjects by a soluble adenovirus receptor-epidermal growth factor (sCAR-EGF) fusion protein. Mol Imaging Biol. 2004 Nov-Dec; 6(6):385-94. PMID: 15564149.
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    86. Liang Q, Yamamoto M, Curiel DT, Herschman HR. Noninvasive imaging of transcriptionally restricted transgene expression following intratumoral injection of an adenovirus in which the COX-2 promoter drives a reporter gene. Mol Imaging Biol. 2004 Nov-Dec; 6(6):395-404. PMID: 15564150.
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    87. Vician LJ, Xu G, Liu W, Feldman JD, Machado HB, Herschman HR. MAPKAP kinase-2 is a primary response gene induced by depolarization in PC12 cells and in brain. J Neurosci Res. 2004 Nov 01; 78(3):315-28. PMID: 15389839.
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    88. Singh V, Miranda TB, Jiang W, Frankel A, Roemer ME, Robb VA, Gutmann DH, Herschman HR, Clarke S, Newsham IF. DAL-1/4.1B tumor suppressor interacts with protein arginine N-methyltransferase 3 (PRMT3) and inhibits its ability to methylate substrates in vitro and in vivo. Oncogene. 2004 Oct 14; 23(47):7761-71. PMID: 15334060.
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    89. Ferguson GD, Herschman HR, Storm DR. Reduced anxiety and depression-like behavior in synaptotagmin IV (-/-) mice. Neuropharmacology. 2004 Sep; 47(4):604-11. PMID: 15380377.
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    90. Herschman HR. PET reporter genes for noninvasive imaging of gene therapy, cell tracking and transgenic analysis. Crit Rev Oncol Hematol. 2004 Sep; 51(3):191-204. PMID: 15331078.
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    91. Machado HB, Liu W, Vician LJ, Herschman HR. Synaptotagmin IV overexpression inhibits depolarization-induced exocytosis in PC12 cells. J Neurosci Res. 2004 May 01; 76(3):334-41. PMID: 15079862.
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    92. Chen IY, Wu JC, Min JJ, Sundaresan G, Lewis X, Liang Q, Herschman HR, Gambhir SS. Micro-positron emission tomography imaging of cardiac gene expression in rats using bicistronic adenoviral vector-mediated gene delivery. Circulation. 2004 Mar 23; 109(11):1415-20. PMID: 15007006; PMCID: PMC4154818.
    93. Herschman HR. Molecular imaging: a view from the inside. J Nucl Cardiol. 2004 Mar-Apr; 11(2):210-4. PMID: 15052251.
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    94. Herschman HR. Noninvasive imaging of reporter gene expression in living subjects. Adv Cancer Res. 2004; 92:29-80. PMID: 15530556.
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    95. Smith JB, Herschman HR. Targeted identification of glucocorticoid-attenuated response genes: in vitro and in vivo models. Proc Am Thorac Soc. 2004; 1(3):275-81. PMID: 16113446.
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    96. Ferguson GD, Wang H, Herschman HR, Storm DR. Altered hippocampal short-term plasticity and associative memory in synaptotagmin IV (-/-) mice. Hippocampus. 2004; 14(8):964-74. PMID: 15390175.
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    97. Symensma TL, Martinez-Guzman D, Jia Q, Bortz E, Wu TT, Rudra-Ganguly N, Cole S, Herschman H, Sun R. COX-2 induction during murine gammaherpesvirus 68 infection leads to enhancement of viral gene expression. J Virol. 2003 Dec; 77(23):12753-63. PMID: 14610197; PMCID: PMC262602.
    98. Herschman HR. Molecular imaging: looking at problems, seeing solutions. Science. 2003 Oct 24; 302(5645):605-8. PMID: 14576425.
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    99. Herschman HR, Talley JJ, DuBois R. Cyclooxygenase 2 (COX-2) as a target for therapy and noninvasive imaging. Mol Imaging Biol. 2003 Sep-Oct; 5(5):286-303. PMID: 14630509.
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    100. Herschman HR. Micro-PET imaging and small animal models of disease. Curr Opin Immunol. 2003 Aug; 15(4):378-84. PMID: 12900267.
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    101. Nguyen JT, Machado H, Herschman HR. Repetitive, noninvasive imaging of cyclooxygenase-2 gene expression in living mice. Mol Imaging Biol. 2003 Jul-Aug; 5(4):248-56. PMID: 14499140.
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    102. Liu W, Feldman JD, Machado HB, Vician LJ, Herschman HR. Expression of depolarization-induced immediate early gene proteins in PC12 cells. J Neurosci Res. 2003 Jun 15; 72(6):670-8. PMID: 12774307.
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    103. Lin HJ, Lakkides KM, Keku TO, Reddy ST, Louie AD, Kau IH, Zhou H, Gim JS, Ma HL, Matthies CF, Dai A, Huang HF, Materi AM, Lin JH, Frankl HD, Lee ER, Hardy SI, Herschman HR, Henderson BE, Kolonel LN, Le Marchand L, Garavito RM, Sandler RS, Haile RW, Smith WL. Prostaglandin H synthase 2 variant (Val511Ala) in African Americans may reduce the risk for colorectal neoplasia. Cancer Epidemiol Biomarkers Prev. 2002 Nov; 11(11):1305-15. PMID: 12433707.
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    104. Smith JB, Wadleigh DJ, Xia YR, Mar RA, Herschman HR, Lusis AJ. Cloning and genomic localization of the murine LPS-induced CXC chemokine (LIX) gene, Scyb5. Immunogenetics. 2002 Nov; 54(8):599-603. PMID: 12439624.
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    105. Smith JB, Nguyen TT, Hughes HJ, Herschman HR, Widney DP, Bui KC, Rovai LE. Glucocorticoid-attenuated response genes induced in the lung during endotoxemia. Am J Physiol Lung Cell Mol Physiol. 2002 Sep; 283(3):L636-47. PMID: 12169584.
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    106. Rudra-Ganguly N, Reddy ST, Korge P, Herschman HR. Diesel exhaust particle extracts and associated polycyclic aromatic hydrocarbons inhibit Cox-2-dependent prostaglandin synthesis in murine macrophages and fibroblasts. J Biol Chem. 2002 Oct 18; 277(42):39259-65. PMID: 12163478.
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    107. Chikazu D, Li X, Kawaguchi H, Sakuma Y, Voznesensky OS, Adams DJ, Xu M, Hoshio K, Katavic V, Herschman HR, Raisz LG, Pilbeam CC. Bone morphogenetic protein 2 induces cyclo-oxygenase 2 in osteoblasts via a Cbfal binding site: role in effects of bone morphogenetic protein 2 in vitro and in vivo. J Bone Miner Res. 2002 Aug; 17(8):1430-40. PMID: 12162497.
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    108. Liang Q, Gotts J, Satyamurthy N, Barrio J, Phelps ME, Gambhir SS, Herschman HR. Noninvasive, repetitive, quantitative measurement of gene expression from a bicistronic message by positron emission tomography, following gene transfer with adenovirus. Mol Ther. 2002 Jul; 6(1):73-82. PMID: 12095306.
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    109. Giza CC, Prins ML, Hovda DA, Herschman HR, Feldman JD. Genes preferentially induced by depolarization after concussive brain injury: effects of age and injury severity. J Neurotrauma. 2002 Apr; 19(4):387-402. PMID: 11990346.
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    110. Cimato TR, Tang J, Xu Y, Guarnaccia C, Herschman HR, Pongor S, Aletta JM. Nerve growth factor-mediated increases in protein methylation occur predominantly at type I arginine methylation sites and involve protein arginine methyltransferase 1. J Neurosci Res. 2002 Feb 15; 67(4):435-42. PMID: 11835310.
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    111. Green LA, Yap CS, Nguyen K, Barrio JR, Namavari M, Satyamurthy N, Phelps ME, Sandgren EP, Herschman HR, Gambhir SS. Indirect monitoring of endogenous gene expression by positron emission tomography (PET) imaging of reporter gene expression in transgenic mice. Mol Imaging Biol. 2002 Jan; 4(1):71-81. PMID: 14538050.
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    112. Herschman HR. Non-invasive imaging of reporter genes. J Cell Biochem Suppl. 2002; 39:36-44. PMID: 12552600.
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    113. Herschman HR, Ferguson GD, Feldman JD, Farias-Eisner R, Vician L. Searching for depolarization-induced genes that modulate synaptic plasticity and neurotrophin-induced genes that mediate neuronal differentiation. Neurochem Res. 2000 May; 25(5):591-602. PMID: 10905620.
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