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Karagueuzian Hrayr S

TitleProfessor
InstitutionUniversity of California Los Angeles
DepartmentMedicine
AddressSINAI
Los Angeles CA 90095
Phone(310) 206-5777
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    TitleFaculty


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Pezhouman A, Cao H, Fishbein MC, Belardinelli L, Weiss JN, Karagueuzian HS. Atrial Fibrillation Initiated by Early Afterdepolarization-Mediated Triggered Activity during Acute Oxidative Stress: Efficacy of Late Sodium Current Blockade. J Heart Health. 2018 Apr 25; 4(1). PMID: 30393761.
      View in: PubMed
    2. Karagueuzian HS, Pezhouman A, Angelini M, Olcese R. Enhanced Late Na and Ca Currents as Effective Antiarrhythmic Drug Targets. Front Pharmacol. 2017; 8:36. PMID: 28220073.
      View in: PubMed
    3. Karagueuzian HS. Synergism between Enhanced Late Inward Currents and Tissue Fibrosis in the Initiation of Spontaneous Ventricular Tachyarrhythmias. J Heart Health. 2016 Mar; 2(2). PMID: 27722204.
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    4. Nguyen TP, Sovari AA, Pezhouman A, Iyer S, Cao H, Ko CY, Bapat A, Vahdani N, Ghanim M, Fishbein MC, Karagueuzian HS. Increased susceptibility of spontaneously hypertensive rats to ventricular tachyarrhythmias in early hypertension. J Physiol. 2016 Mar 15; 594(6):1689-707. PMID: 26775607; PMCID: PMC4799964 [Available on 03/15/17].
    5. Prudat Y, Madhvani RV, Angelini M, Borgstom NP, Garfinkel A, Karagueuzian HS, Weiss JN, de Lange E, Olcese R, Kucera JP. Stochastic pacing reveals the propensity to cardiac action potential alternans and uncovers its underlying dynamics. J Physiol. 2016 05 01; 594(9):2537-53. PMID: 26563830; PMCID: PMC4850193 [Available on 04/28/17].
    6. Pezhouman A, Singh N, Song Z, Nivala M, Eskandari A, Cao H, Bapat A, Ko CY, Nguyen T, Qu Z, Karagueuzian HS, Weiss JN. Molecular Basis of Hypokalemia-Induced Ventricular Fibrillation. Circulation. 2015 Oct 20; 132(16):1528-1537. PMID: 26269574; PMCID: PMC4618042 [Available on 10/20/16].
    7. Weiss JN, Garfinkel A, Karagueuzian HS, Nguyen TP, Olcese R, Chen PS, Qu Z. Perspective: a dynamics-based classification of ventricular arrhythmias. J Mol Cell Cardiol. 2015 May; 82:136-52. PMID: 25769672; PMCID: PMC4405495.
    8. Morita N, Mandel WJ, Kobayashi Y, Karagueuzian HS. Cardiac fibrosis as a determinant of ventricular tachyarrhythmias. J Arrhythm. 2014 Dec 01; 30(6):389-394. PMID: 25642299.
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    9. Belardinelli L, Giles WR, Rajamani S, Karagueuzian HS, Shryock JC. Cardiac late Na? current: proarrhythmic effects, roles in long QT syndromes, and pathological relationship to CaMKII and oxidative stress. Heart Rhythm. 2015 Feb; 12(2):440-8. PMID: 25460862.
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    10. Pezhouman A, Madahian S, Stepanyan H, Ghukasyan H, Qu Z, Belardinelli L, Karagueuzian HS. Selective inhibition of late sodium current suppresses ventricular tachycardia and fibrillation in intact rat hearts. Heart Rhythm. 2014 Mar; 11(3):492-501. PMID: 24291413; PMCID: PMC3963462.
    11. Groenke S, Larson ED, Alber S, Zhang R, Lamp ST, Ren X, Nakano H, Jordan MC, Karagueuzian HS, Roos KP, Nakano A, Proenza C, Philipson KD, Goldhaber JI. Complete atrial-specific knockout of sodium-calcium exchange eliminates sinoatrial node pacemaker activity. PLoS One. 2013; 8(11):e81633. PMID: 24278453; PMCID: PMC3836769.
    12. Karagueuzian HS. Letter to the editor: "The role of short QT interval and elevated LV end-diastolic pressure in the genesis of ventricular tachycardia and fibrillation". Am J Physiol Heart Circ Physiol. 2013 Nov 01; 305(9):H1405. PMID: 24186859.
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    13. Karagueuzian HS. The "nervous" kidney and ventricular fibrillation: a possible game changer? Heart Rhythm. 2013 Oct; 10(10):1531-2. PMID: 23872697; PMCID: PMC4517445.
    14. Qu Z, Xie LH, Olcese R, Karagueuzian HS, Chen PS, Garfinkel A, Weiss JN. Early afterdepolarizations in cardiac myocytes: beyond reduced repolarization reserve. Cardiovasc Res. 2013 Jul 01; 99(1):6-15. PMID: 23619423; PMCID: PMC3687754.
    15. Karagueuzian HS, Stepanyan H, Mandel WJ. Bifurcation theory and cardiac arrhythmias. Am J Cardiovasc Dis. 2013; 3(1):1-16. PMID: 23459417; PMCID: PMC3584649.
    16. Karagueuzian HS, Nguyen TP, Qu Z, Weiss JN. Oxidative stress, fibrosis, and early afterdepolarization-mediated cardiac arrhythmias. Front Physiol. 2013; 4:19. PMID: 23423152; PMCID: PMC3573324.
    17. Chang MG, Chang CY, de Lange E, Xu L, O'Rourke B, Karagueuzian HS, Tung L, Marbán E, Garfinkel A, Weiss JN, Qu Z, Abraham MR. Dynamics of early afterdepolarization-mediated triggered activity in cardiac monolayers. Biophys J. 2012 Jun 20; 102(12):2706-14. PMID: 22735520; PMCID: PMC3379011.
    18. Bapat A, Nguyen TP, Lee JH, Sovari AA, Fishbein MC, Weiss JN, Karagueuzian HS. Enhanced sensitivity of aged fibrotic hearts to angiotensin II- and hypokalemia-induced early afterdepolarization-mediated ventricular arrhythmias. Am J Physiol Heart Circ Physiol. 2012 Jun 01; 302(11):H2331-40. PMID: 22467308; PMCID: PMC3378307.
    19. Umar S, Lee JH, de Lange E, Iorga A, Partow-Navid R, Bapat A, van der Laarse A, Saggar R, Saggar R, Ypey DL, Karagueuzian HS, Eghbali M. Spontaneous ventricular fibrillation in right ventricular failure secondary to chronic pulmonary hypertension. Circ Arrhythm Electrophysiol. 2012 Feb; 5(1):181-90. PMID: 22199010; PMCID: PMC3319685.
    20. Numata A, Miyauchi Y, Ono N, Fishbein MC, Mandel WJ, Lin SF, Weiss JN, Chen PS, Karagueuzian HS. Spontaneous atrial fibrillation initiated by tyramine in canine atria with increased sympathetic nerve sprouting. J Cardiovasc Electrophysiol. 2012 Apr; 23(4):415-22. PMID: 22034958; PMCID: PMC4364657.
    21. Karagueuzian HS, White C, Sayre J, Norman A. Cigarette smoke radioactivity and lung cancer risk. Nicotine Tob Res. 2012 Jan; 14(1):79-90. PMID: 21956761.
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    22. Chang MG, Sato D, de Lange E, Lee JH, Karagueuzian HS, Garfinkel A, Weiss JN, Qu Z. Bi-stable wave propagation and early afterdepolarization-mediated cardiac arrhythmias. Heart Rhythm. 2012 Jan; 9(1):115-22. PMID: 21855520; PMCID: PMC3246094.
    23. Sovari AA, Karagueuzian HS. Myocardial fibrosis as a risk stratifier for sudden arrhythmic death. Expert Rev Cardiovasc Ther. 2011 Aug; 9(8):951-3. PMID: 21878039.
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    24. Karagueuzian HS. Targeting cardiac fibrosis: a new frontier in antiarrhythmic therapy? Am J Cardiovasc Dis. 2011; 1(2):101-9. PMID: 22254191; PMCID: PMC3253497.
    25. Morita N, Lee JH, Bapat A, Fishbein MC, Mandel WJ, Chen PS, Weiss JN, Karagueuzian HS. Glycolytic inhibition causes spontaneous ventricular fibrillation in aged hearts. Am J Physiol Heart Circ Physiol. 2011 Jul; 301(1):H180-91. PMID: 21478408; PMCID: PMC3302192.
    26. Morita N, Lee JH, Xie Y, Sovari A, Qu Z, Weiss JN, Karagueuzian HS. Suppression of re-entrant and multifocal ventricular fibrillation by the late sodium current blocker ranolazine. J Am Coll Cardiol. 2011 Jan 18; 57(3):366-75. PMID: 21232675; PMCID: PMC4344130.
    27. Karagueuzian HS. How does cholinergic activation slow down sinus node automaticity?"diastolic voltage oscillations" vs. "calcium clock" mechanisms. J Cardiovasc Electrophysiol. 2011 Jan; 22(1):81-3. PMID: 20653806; PMCID: PMC4511959.
    28. Karagueuzian HS. Triggered activity, coronary sinus, and atrial fibrillation. Heart Rhythm. 2010 Dec; 7(12):e4. PMID: 20970521.
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    29. Weiss JN, Garfinkel A, Karagueuzian HS, Chen PS, Qu Z. Early afterdepolarizations and cardiac arrhythmias. Heart Rhythm. 2010 Dec; 7(12):1891-9. PMID: 20868774; PMCID: PMC3005298.
    30. Morita N, Sovari AA, Xie Y, Fishbein MC, Mandel WJ, Garfinkel A, Lin SF, Chen PS, Xie LH, Chen F, Qu Z, Weiss JN, Karagueuzian HS. Increased susceptibility of aged hearts to ventricular fibrillation during oxidative stress. Am J Physiol Heart Circ Physiol. 2009 Nov; 297(5):H1594-605. PMID: 19767530; PMCID: PMC2781379.
    31. Sato D, Xie LH, Sovari AA, Tran DX, Morita N, Xie F, Karagueuzian H, Garfinkel A, Weiss JN, Qu Z. Synchronization of chaotic early afterdepolarizations in the genesis of cardiac arrhythmias. Proc Natl Acad Sci U S A. 2009 Mar 03; 106(9):2983-8. PMID: 19218447; PMCID: PMC2651322.
    32. Ogawa M, Morita N, Tang L, Karagueuzian HS, Weiss JN, Lin SF, Chen PS. Mechanisms of recurrent ventricular fibrillation in a rabbit model of pacing-induced heart failure. Heart Rhythm. 2009 Jun; 6(6):784-92. PMID: 19467505; PMCID: PMC2752449.
    33. Xie LH, Chen F, Karagueuzian HS, Weiss JN. Oxidative-stress-induced afterdepolarizations and calmodulin kinase II signaling. Circ Res. 2009 Jan 02; 104(1):79-86. PMID: 19038865; PMCID: PMC2747806.
    34. Hwang GS, Tang L, Joung B, Morita N, Hayashi H, Karagueuzian HS, Weiss JN, Lin SF, Chen PS. Superiority of biphasic over monophasic defibrillation shocks is attributable to less intracellular calcium transient heterogeneity. J Am Coll Cardiol. 2008 Sep 02; 52(10):828-35. PMID: 18755345; PMCID: PMC2573049.
    35. Hayashi H, Lin SF, Joung B, Karagueuzian HS, Weiss JN, Chen PS. Virtual electrodes and the induction of fibrillation in Langendorff-perfused rabbit ventricles: the role of intracellular calcium. Am J Physiol Heart Circ Physiol. 2008 Oct; 295(4):H1422-8. PMID: 18676691; PMCID: PMC2593494.
    36. Tang L, Hwang GS, Hayashi H, Song J, Ogawa M, Kobayashi K, Joung B, Karagueuzian HS, Chen PS, Lin SF. Intracellular calcium dynamics at the core of endocardial stationary spiral waves in Langendorff-perfused rabbit hearts. Am J Physiol Heart Circ Physiol. 2008 Jul; 295(1):H297-304. PMID: 18487432; PMCID: PMC2494742.
    37. Sovari AA, Morita N, Weiss JN, Karagueuzian HS. Serum transforming growth factor-beta1 as a risk stratifier of sudden cardiac death. Med Hypotheses. 2008 Aug; 71(2):262-5. PMID: 18448260; PMCID: PMC3063398.
    38. Karagueuzian HS. Chasing with ranolazine pulmonary vein afterpotentials before it's too late. Heart Rhythm. 2008 Jul; 5(7):1027-8. PMID: 18598959; PMCID: PMC3652621.
    39. Sovari AA, Morita N, Karagueuzian HS. Apocynin: a potent NADPH oxidase inhibitor for the management of atrial fibrillation. Redox Rep. 2008; 13(6):242-5. PMID: 19017463.
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    40. Hayashi H, Kamanu SD, Ono N, Kawase A, Chou CC, Weiss JN, Karagueuzian HS, Lin SF, Chen PS. Calcium transient dynamics and the mechanisms of ventricular vulnerability to single premature electrical stimulation in Langendorff-perfused rabbit ventricles. Heart Rhythm. 2008 Jan; 5(1):116-23. PMID: 18180025; PMCID: PMC2756777.
    41. Karagueuzian HS. On the mechanisms of transmural dispersion of myocardial mechanics. J Am Coll Cardiol. 2007 Aug 14; 50(7):649-50; author reply 650. PMID: 17692752.
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    42. Ogawa M, Zhou S, Tan AY, Song J, Gholmieh G, Fishbein MC, Luo H, Siegel RJ, Karagueuzian HS, Chen LS, Lin SF, Chen PS. Left stellate ganglion and vagal nerve activity and cardiac arrhythmias in ambulatory dogs with pacing-induced congestive heart failure. J Am Coll Cardiol. 2007 Jul 24; 50(4):335-43. PMID: 17659201.
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    43. Karagueuzian HS. Radiofrequency lesions made in canine and swine atria at the proximal coronary sinus prevent rapid pacing-induced atrial fibrillation. J Cardiovasc Electrophysiol. 2007 Jun; 18(6):E17; author reply E18. PMID: 17504252.
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    44. Karagueuzian HS. Re: mechanism of origin of conduction disturbances in aging human atrial bundles: experimental and model study. Heart Rhythm. 2007 Jul; 4(7):989; author reply 989-90. PMID: 17599692; PMCID: PMC1948847.
    45. Chen PS, Chou CC, Tan AY, Zhou S, Fishbein MC, Hwang C, Karagueuzian HS, Lin SF. The mechanisms of atrial fibrillation. J Cardiovasc Electrophysiol. 2006 Dec; 17 Suppl 3:S2-7. PMID: 17121663.
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    46. Hwang GS, Hayashi H, Tang L, Ogawa M, Hernandez H, Tan AY, Li H, Karagueuzian HS, Weiss JN, Lin SF, Chen PS. Intracellular calcium and vulnerability to fibrillation and defibrillation in Langendorff-perfused rabbit ventricles. Circulation. 2006 Dec 12; 114(24):2595-603. PMID: 17116770.
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    47. Ono N, Hayashi H, Kawase A, Lin SF, Li H, Weiss JN, Chen PS, Karagueuzian HS. Spontaneous atrial fibrillation initiated by triggered activity near the pulmonary veins in aged rats subjected to glycolytic inhibition. Am J Physiol Heart Circ Physiol. 2007 Jan; 292(1):H639-48. PMID: 16920811.
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    48. Karagueuzian HS. On early afterdepolarization, triggered activity, and defibrillation shock failure. J Cardiovasc Electrophysiol. 2006 Apr; 17(4):456; author reply 456-7. PMID: 16643376.
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    49. Miyauchi Y, Hayashi H, Miyauchi M, Okuyama Y, Mandel WJ, Chen PS, Karagueuzian HS. Heterogeneous pulmonary vein myocardial cell repolarization implications for reentry and triggered activity. Heart Rhythm. 2005 Dec; 2(12):1339-45. PMID: 16360087.
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    50. Karagueuzian HS. Letter regarding article by Korte et al, "Female mice lacking estrogen receptor beta display prolonged ventricular repolarization and reduced ventricular automaticity after myocardial infarction". Circulation. 2005 Oct 18; 112(16):e272; author reply e272. PMID: 16230492.
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    51. Weiss JN, Qu Z, Chen PS, Lin SF, Karagueuzian HS, Hayashi H, Garfinkel A, Karma A. The dynamics of cardiac fibrillation. Circulation. 2005 Aug 23; 112(8):1232-40. PMID: 16116073.
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    52. Karagueuzian HS. More on Philip Coumel. Heart Rhythm. 2005 Feb; 2(2):220. PMID: 15851306.
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    53. Miyauchi M, Qu Z, Miyauchi Y, Zhou SM, Pak H, Mandel WJ, Fishbein MC, Chen PS, Karagueuzian HS. Chronic nicotine in hearts with healed ventricular myocardial infarction promotes atrial flutter that resembles typical human atrial flutter. Am J Physiol Heart Circ Physiol. 2005 Jun; 288(6):H2878-86. PMID: 15665050.
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    54. Okuyama Y, Pak HN, Miyauchi Y, Liu YB, Chou CC, Hayashi H, Fu KJ, Kerwin WF, Kar S, Hata C, Karagueuzian HS, Fishbein MC, Chen PS, Chen LS. Nerve sprouting induced by radiofrequency catheter ablation in dogs. Heart Rhythm. 2004 Dec; 1(6):712-7. PMID: 15851243.
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    55. Chou CC, Zhou S, Miyauchi Y, Pak HN, Okuyama Y, Fishbein MC, Karagueuzian HS, Chen PS. Effects of procainamide on electrical activity in thoracic veins and atria in canine model of sustained atrial fibrillation. Am J Physiol Heart Circ Physiol. 2004 May; 286(5):H1936-45. PMID: 15072975.
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    56. Karagueuzian HS. Ventricular fibrillation: an organized delirium or uncoordinated reason? Heart Rhythm. 2004 May; 1(1):24-6. PMID: 15851111.
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    57. Zhou S, Cao JM, Swissa M, Gonzalez-Gomez I, Chang CM, Chien K, Miyauchi Y, Fu KJ, Yi J, Asotra K, Karagueuzian HS, Fishbein MC, Chen PS, Chen LS. Low-affinity nerve growth factor receptor p75NTR immunoreactivity in the myocardium with sympathetic hyperinnervation. J Cardiovasc Electrophysiol. 2004 Apr; 15(4):430-7. PMID: 15089992.
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    58. Miyauchi Y, Fishbein MC, Karagueuzian HS. Electrical current-induced atrial and pulmonary vein action potential duration shortening and repetitive activity. Am J Physiol Heart Circ Physiol. 2004 Jul; 287(1):H178-86. PMID: 15001438.
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    59. Swissa M, Zhou S, Gonzalez-Gomez I, Chang CM, Lai AC, Cates AW, Fishbein MC, Karagueuzian HS, Chen PS, Chen LS. Long-term subthreshold electrical stimulation of the left stellate ganglion and a canine model of sudden cardiac death. J Am Coll Cardiol. 2004 Mar 03; 43(5):858-64. PMID: 14998630.
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    60. Park AM, Chou CC, Drury PC, Okuyama Y, Peter A, Hamabe A, Miyauchi Y, Kass RM, Karagueuzian HS, Fishbein MC, Lin SF, Chen PS. Thoracic vein ablation terminates chronic atrial fibrillation in dogs. Am J Physiol Heart Circ Physiol. 2004 Jun; 286(6):H2072-7. PMID: 14751866.
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    61. Omichi C, Lamp ST, Lin SF, Yang J, Baher A, Zhou S, Attin M, Lee MH, Karagueuzian HS, Kogan B, Qu Z, Garfinkel A, Chen PS, Weiss JN. Intracellular Ca dynamics in ventricular fibrillation. Am J Physiol Heart Circ Physiol. 2004 May; 286(5):H1836-44. PMID: 14704235.
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    62. Pak HN, Oh YS, Liu YB, Wu TJ, Karagueuzian HS, Lin SF, Chen PS. Catheter ablation of ventricular fibrillation in rabbit ventricles treated with beta-blockers. Circulation. 2003 Dec 23; 108(25):3149-56. PMID: 14656917.
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    63. Hamabe A, Chang CM, Zhou S, Chou CC, Yi J, Miyauchi Y, Okuyama Y, Fishbein MC, Karagueuzian HS, Chen LS, Chen PS, Akira H. Induction of atrial fibrillation and nerve sprouting by prolonged left atrial pacing in dogs. Pacing Clin Electrophysiol. 2003 Dec; 26(12):2247-52. PMID: 14675008.
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    64. Qu Z, Karagueuzian HS, Garfinkel A, Weiss JN. Effects of Na(+) channel and cell coupling abnormalities on vulnerability to reentry: a simulation study. Am J Physiol Heart Circ Physiol. 2004 Apr; 286(4):H1310-21. PMID: 14630634.
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    65. Chen PS, Wu TJ, Ting CT, Karagueuzian HS, Garfinkel A, Lin SF, Weiss JN. A tale of two fibrillations. Circulation. 2003 Nov 11; 108(19):2298-303. PMID: 14609997.
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    66. Hayashi H, Omichi C, Miyauchi Y, Mandel WJ, Lin SF, Chen PS, Karagueuzian HS. Age-related sensitivity to nicotine for inducible atrial tachycardia and atrial fibrillation. Am J Physiol Heart Circ Physiol. 2003 Nov; 285(5):H2091-8. PMID: 14561681.
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    67. Hayashi H, Miyauchi Y, Chou CC, Karagueuzian HS, Chen PS, Lin SF. Effects of cytochalasin D on electrical restitution and the dynamics of ventricular fibrillation in isolated rabbit heart. J Cardiovasc Electrophysiol. 2003 Oct; 14(10):1077-84. PMID: 14521661.
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    68. Okuyama Y, Miyauchi Y, Park AM, Hamabe A, Zhou S, Hayashi H, Miyauchi M, Omichi C, Pak HN, Brodsky LA, Mandel WJ, Fishbein MC, Karagueuzian HS, Chen PS. High resolution mapping of the pulmonary vein and the vein of Marshall during induced atrial fibrillation and atrial tachycardia in a canine model of pacing-induced congestive heart failure. J Am Coll Cardiol. 2003 Jul 16; 42(2):348-60. PMID: 12875775.
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    69. Miyauchi Y, Zhou S, Okuyama Y, Miyauchi M, Hayashi H, Hamabe A, Fishbein MC, Mandel WJ, Chen LS, Chen PS, Karagueuzian HS. Altered atrial electrical restitution and heterogeneous sympathetic hyperinnervation in hearts with chronic left ventricular myocardial infarction: implications for atrial fibrillation. Circulation. 2003 Jul 22; 108(3):360-6. PMID: 12835207.
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    70. Hamabe A, Okuyama Y, Miyauchi Y, Zhou S, Pak HN, Karagueuzian HS, Fishbein MC, Chen PS. Correlation between anatomy and electrical activation in canine pulmonary veins. Circulation. 2003 Mar 25; 107(11):1550-5. PMID: 12654615.
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    71. Weiss JN, Chen PS, Qu Z, Karagueuzian HS, Lin SF, Garfinkel A, Karma A. Effects of the excitation-contraction uncouplers diamine monoxime (DAM) and cytochalasin D (CytoD) on induced arrhythmias in the rabbit ventricle. J Cardiovasc Electrophysiol. 2003 Mar; 14(3):331-2; author reply 332-4. PMID: 12716123.
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    72. Omichi C, Chou CC, Lee MH, Chang CM, Lai AC, Hayashi H, Zhou S, Miyauchi Y, Okuyama Y, Hamabe A, Hwang C, Fishbein MC, Lin SF, Karagueuzian HS, Chen PS. Demonstration of electrical and anatomic connections between Marshall bundles and left atrium in dogs: implications on the generation of P waves on surface electrocardiogram. J Cardiovasc Electrophysiol. 2002 Dec; 13(12):1283-91. PMID: 12521347.
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    73. Yashima M, Kim YH, Armin S, Wu TJ, Miyauchi Y, Mandel WJ, Chen PS, Karagueuzian HS. On the mechanism of the probabilistic nature of ventricular defibrillation threshold. Am J Physiol Heart Circ Physiol. 2003 Jan; 284(1):H249-55. PMID: 12388279.
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    74. Zhou S, Chang CM, Wu TJ, Miyauchi Y, Okuyama Y, Park AM, Hamabe A, Omichi C, Hayashi H, Brodsky LA, Mandel WJ, Ting CT, Fishbein MC, Karagueuzian HS, Chen PS. Nonreentrant focal activations in pulmonary veins in canine model of sustained atrial fibrillation. Am J Physiol Heart Circ Physiol. 2002 Sep; 283(3):H1244-52. PMID: 12181156.
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    75. Ohara T, Qu Z, Lee MH, Ohara K, Omichi C, Mandel WJ, Chen PS, Karagueuzian HS. Increased vulnerability to inducible atrial fibrillation caused by partial cellular uncoupling with heptanol. Am J Physiol Heart Circ Physiol. 2002 Sep; 283(3):H1116-22. PMID: 12181142.
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    76. Hayashi H, Wang C, Miyauchi Y, Omichi C, Pak HN, Zhou S, Ohara T, Mandel WJ, Lin SF, Fishbein MC, Chen PS, Karagueuzian HS. Aging-related increase to inducible atrial fibrillation in the rat model. J Cardiovasc Electrophysiol. 2002 Aug; 13(8):801-8. PMID: 12212701.
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    77. Wu TJ, Doshi RN, Huang HL, Blanche C, Kass RM, Trento A, Cheng W, Karagueuzian HS, Peter CT, Chen PS. Simultaneous biatrial computerized mapping during permanent atrial fibrillation in patients with organic heart disease. J Cardiovasc Electrophysiol. 2002 Jun; 13(6):571-7. PMID: 12108499.
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    78. Chen PS, Wu TJ, Hwang C, Zhou S, Okuyama Y, Hamabe A, Miyauchi Y, Chang CM, Chen LS, Fishbein MC, Karagueuzian HS. Thoracic veins and the mechanisms of non-paroxysmal atrial fibrillation. Cardiovasc Res. 2002 May; 54(2):295-301. PMID: 12062335.
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    79. Swissa M, Ohara T, Lee MH, Kaul S, Shah PK, Hayashi H, Chen PS, Karagueuzian HS. Sildenafil-nitric oxide donor combination promotes ventricular tachyarrhythmias in the swine right ventricle. Am J Physiol Heart Circ Physiol. 2002 May; 282(5):H1787-92. PMID: 11959644.
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    80. Swissa M, Qu Z, Ohara T, Lee MH, Lin SF, Garfinkel A, Karagueuzian HS, Weiss JN, Chen PS. Action potential duration restitution and ventricular fibrillation due to rapid focal excitation. Am J Physiol Heart Circ Physiol. 2002 May; 282(5):H1915-23. PMID: 11959659.
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    81. Ohara K, Miyauchi Y, Ohara T, Fishbein MC, Zhou S, Lee MH, Mandel WJ, Chen PS, Karagueuzian HS. Downregulation of immunodetectable atrial connexin40 in a canine model of chronic left ventricular myocardial infarction: implications to atrial fibrillation. J Cardiovasc Pharmacol Ther. 2002 Apr; 7(2):89-94. PMID: 12075397.
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    82. Weiss JN, Chen PS, Qu Z, Karagueuzian HS, Lin SF, Garfinkel A. Electrical restitution and cardiac fibrillation. J Cardiovasc Electrophysiol. 2002 Mar; 13(3):292-5. PMID: 11942602.
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    83. Omichi C, Zhou S, Lee MH, Naik A, Chang CM, Garfinkel A, Weiss JN, Lin SF, Karagueuzian HS, Chen PS. Effects of amiodarone on wave front dynamics during ventricular fibrillation in isolated swine right ventricle. Am J Physiol Heart Circ Physiol. 2002 Mar; 282(3):H1063-70. PMID: 11834505.
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    84. Valderrábano M, Yang J, Omichi C, Kil J, Lamp ST, Qu Z, Lin SF, Karagueuzian HS, Garfinkel A, Chen PS, Weiss JN. Frequency analysis of ventricular fibrillation in Swine ventricles. Circ Res. 2002 Feb 08; 90(2):213-22. PMID: 11834715.
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    85. Zhou S, Cao JM, Ohara T, KenKnight BH, Chen LS, Karagueuzian HS, Chen PS. Torsade de pointes and sudden death induced by thiopental and isoflurane anesthesia in dogs with cardiac electrical remodeling. J Cardiovasc Pharmacol Ther. 2002 Jan; 7(1):39-43. PMID: 12000977.
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    86. Hamzei A, Ohara T, Kim YH, Lee MH, Voroshilovski O, Lin SF, Weiss JN, Chen PS, Karagueuzian HS. The role of approximate entropy in predicting ventricular defibrillation threshold. J Cardiovasc Pharmacol Ther. 2002 Jan; 7(1):45-52. PMID: 12000978.
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    87. Tsai J, Cao JM, Zhou S, Swissa M, Cates AW, Kenknight BH, Chen LS, Karagueuzian HS, Chen PS. T wave alternans as a predictor of spontaneous ventricular tachycardia in a canine model of sudden cardiac death. J Cardiovasc Electrophysiol. 2002 Jan; 13(1):51-5. PMID: 11843483.
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    88. Wu TJ, Kim YH, Yashima M, Athill CA, Ting CT, Karagueuzian HS, Chen PS. Progressive action potential duration shortening and the conversion from atrial flutter to atrial fibrillation in the isolated canine right atrium. J Am Coll Cardiol. 2001 Nov 15; 38(6):1757-65. PMID: 11704392.
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    89. Zhou S, Cao JM, Tebb ZD, Ohara T, Huang HL, Omichi C, Lee MH, Kenknight BH, Chen LS, Fishbein MC, Karagueuzian HS, Chen PS. Modulation of QT interval by cardiac sympathetic nerve sprouting and the mechanisms of ventricular arrhythmia in a canine model of sudden cardiac death. J Cardiovasc Electrophysiol. 2001 Sep; 12(9):1068-73. PMID: 11573698.
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    90. Wang NC, Lee MH, Ohara T, Okuyama Y, Fishbein GA, Lin SF, Karagueuzian HS, Chen PS. Optical mapping of ventricular defibrillation in isolated swine right ventricles: demonstration of a postshock isoelectric window after near-threshold defibrillation shocks. Circulation. 2001 Jul 10; 104(2):227-33. PMID: 11447091.
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    91. Lee MH, Qu Z, Fishbein GA, Lamp ST, Chang EH, Ohara T, Voroshilovsky O, Kil JR, Hamzei AR, Wang NC, Lin SF, Weiss JN, Garfinkel A, Karagueuzian HS, Chen PS. Patterns of wave break during ventricular fibrillation in isolated swine right ventricle. Am J Physiol Heart Circ Physiol. 2001 Jul; 281(1):H253-65. PMID: 11406492.
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    92. Lee MH, Lin SF, Ohara T, Omichi C, Okuyama Y, Chudin E, Garfinkel A, Weiss JN, Karagueuzian HS, Chen PS. Effects of diacetyl monoxime and cytochalasin D on ventricular fibrillation in swine right ventricles. Am J Physiol Heart Circ Physiol. 2001 Jun; 280(6):H2689-96. PMID: 11356625.
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    93. Karagueuzian HS, Chen PS. Cellular mechanism of reentry induced by a strong electrical stimulus: implications for fibrillation and defibrillation. Cardiovasc Res. 2001 May; 50(2):251-62. PMID: 11334829.
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    94. Chen PS, Chen LS, Cao JM, Sharifi B, Karagueuzian HS, Fishbein MC. Sympathetic nerve sprouting, electrical remodeling and the mechanisms of sudden cardiac death. Cardiovasc Res. 2001 May; 50(2):409-16. PMID: 11334845.
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    95. Valderrábano M, Lee MH, Ohara T, Lai AC, Fishbein MC, Lin SF, Karagueuzian HS, Chen PS. Dynamics of intramural and transmural reentry during ventricular fibrillation in isolated swine ventricles. Circ Res. 2001 Apr 27; 88(8):839-48. PMID: 11325877.
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    96. Chen PS, Karagueuzian HS, Kim YH. Papillary muscle hypothesis of idiopathic left ventricular tachycardia. J Am Coll Cardiol. 2001 Apr; 37(5):1475-6. PMID: 11300466.
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    97. Ohara T, Ohara K, Cao JM, Lee MH, Fishbein MC, Mandel WJ, Chen PS, Karagueuzian HS. Increased wave break during ventricular fibrillation in the epicardial border zone of hearts with healed myocardial infarction. Circulation. 2001 Mar 13; 103(10):1465-72. PMID: 11245654.
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    98. Wu TJ, Ong JJ, Chang CM, Doshi RN, Yashima M, Huang HL, Fishbein MC, Ting CT, Karagueuzian HS, Chen PS. Pulmonary veins and ligament of Marshall as sources of rapid activations in a canine model of sustained atrial fibrillation. Circulation. 2001 Feb 27; 103(8):1157-63. PMID: 11222481.
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    99. Chang CM, Wu TJ, Zhou S, Doshi RN, Lee MH, Ohara T, Fishbein MC, Karagueuzian HS, Chen PS, Chen LS. Nerve sprouting and sympathetic hyperinnervation in a canine model of atrial fibrillation produced by prolonged right atrial pacing. Circulation. 2001 Jan 02; 103(1):22-5. PMID: 11136680.
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    100. Weiss JN, Chen PS, Qu Z, Karagueuzian HS, Garfinkel A. Ventricular fibrillation: how do we stop the waves from breaking? Circ Res. 2000 Dec 08; 87(12):1103-7. PMID: 11110766.
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    101. Lai AC, Wallner K, Cao JM, Chen LS, Karagueuzian HS, Fishbein MC, Chen PS, Sharifi BG. Colocalization of tenascin and sympathetic nerves in a canine model of nerve sprouting and sudden cardiac death. J Cardiovasc Electrophysiol. 2000 Dec; 11(12):1345-51. PMID: 11196557.
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    102. Omichi C, Lee MH, Ohara T, Naik AM, Wang NC, Karagueuzian HS, Chen PS. Comparing cardiac action potentials recorded with metal and glass microelectrodes. Am J Physiol Heart Circ Physiol. 2000 Dec; 279(6):H3113-7. PMID: 11087269.
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    103. Valderrábano M, Kim YH, Yashima M, Wu TJ, Karagueuzian HS, Chen PS. Obstacle-induced transition from ventricular fibrillation to tachycardia in isolated swine right ventricles: insights into the transition dynamics and implications for the critical mass. J Am Coll Cardiol. 2000 Nov 15; 36(6):2000-8. PMID: 11092677.
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    104. Kim DT, Lai AC, Hwang C, Fan LT, Karagueuzian HS, Chen PS, Fishbein MC. The ligament of Marshall: a structural analysis in human hearts with implications for atrial arrhythmias. J Am Coll Cardiol. 2000 Oct; 36(4):1324-7. PMID: 11028490.
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    105. Voroshilovsky O, Qu Z, Lee MH, Ohara T, Fishbein GA, Huang HL, Swerdlow CD, Lin SF, Garfinkel A, Weiss JN, Karagueuzian HS, Chen PS. Mechanisms of ventricular fibrillation induction by 60-Hz alternating current in isolated swine right ventricle. Circulation. 2000 Sep 26; 102(13):1569-74. PMID: 11004149.
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    106. Athill CA, Wu TJ, Yashima M, Kim YH, Weiss JN, Huang HL, Karagueuzian HS, Chen PS. Influence of wavefront dynamics on transmembrane potential characteristics during atrial fibrillation. J Cardiovasc Electrophysiol. 2000 Aug; 11(8):913-21. PMID: 10969755.
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    107. Yashima M, Ohara T, Cao JM, Kim YH, Fishbein MC, Mandel WJ, Chen PS, Karagueuzian HS. Nicotine increases ventricular vulnerability to fibrillation in hearts with healed myocardial infarction. Am J Physiol Heart Circ Physiol. 2000 Jun; 278(6):H2124-33. PMID: 10843912.
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    108. Karagueuzian HS, Chen PS. Fibrillation and defibrillation: the odd couple? J Cardiovasc Electrophysiol. 2000 Jun; 11(6):642-4. PMID: 10868737.
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    109. Karagueuzian HS, Chen PS. Various ways to make phase singularities by electric shock. J Cardiovasc Electrophysiol. 2000 Jun; 11(6):717. PMID: 10868749.
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    110. Garfinkel A, Kim YH, Voroshilovsky O, Qu Z, Kil JR, Lee MH, Karagueuzian HS, Weiss JN, Chen PS. Preventing ventricular fibrillation by flattening cardiac restitution. Proc Natl Acad Sci U S A. 2000 May 23; 97(11):6061-6. PMID: 10811880; PMCID: PMC18558.
    111. Cao JM, Chen LS, KenKnight BH, Ohara T, Lee MH, Tsai J, Lai WW, Karagueuzian HS, Wolf PL, Fishbein MC, Chen PS. Nerve sprouting and sudden cardiac death. Circ Res. 2000 Apr 14; 86(7):816-21. PMID: 10764417.
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    112. Chen PS, Athill CA, Wu TJ, Ikeda T, Ong JJ, Karagueuzian HS. Mechanisms of atrial fibrillation and flutter and implications for management. Am J Cardiol. 1999 Nov 04; 84(9A):125R-130R. PMID: 10568671.
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    113. Kim YH, Xie F, Yashima M, Wu TJ, Valderrábano M, Lee MH, Ohara T, Voroshilovsky O, Doshi RN, Fishbein MC, Qu Z, Garfinkel A, Weiss JN, Karagueuzian HS, Chen PS. Role of papillary muscle in the generation and maintenance of reentry during ventricular tachycardia and fibrillation in isolated swine right ventricle. Circulation. 1999 Sep 28; 100(13):1450-9. PMID: 10500048.
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    114. Doshi RN, Wu TJ, Yashima M, Kim YH, Ong JJ, Cao JM, Hwang C, Yashar P, Fishbein MC, Karagueuzian HS, Chen PS. Relation between ligament of Marshall and adrenergic atrial tachyarrhythmia. Circulation. 1999 Aug 24; 100(8):876-83. PMID: 10458726.
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    115. Kim YH, Yashima M, Wu TJ, Doshi R, Chen PS, Karagueuzian HS. Mechanism of procainamide-induced prevention of spontaneous wave break during ventricular fibrillation. Insight into the maintenance of fibrillation wave fronts. Circulation. 1999 Aug 10; 100(6):666-74. PMID: 10441106.
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    116. Wu TJ, Yashima M, Doshi R, Kim YH, Athill CA, Ong JJ, Czer L, Trento A, Blanche C, Kass RM, Garfinkel A, Weiss JN, Fishbein MC, Karagueuzian HS, Chen PS. Relation between cellular repolarization characteristics and critical mass for human ventricular fibrillation. J Cardiovasc Electrophysiol. 1999 Aug; 10(8):1077-86. PMID: 10466488.
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    117. Cao JM, Qu Z, Kim YH, Wu TJ, Garfinkel A, Weiss JN, Karagueuzian HS, Chen PS. Spatiotemporal heterogeneity in the induction of ventricular fibrillation by rapid pacing: importance of cardiac restitution properties. Circ Res. 1999 Jun 11; 84(11):1318-31. PMID: 10364570.
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    118. Weiss JN, Garfinkel A, Karagueuzian HS, Qu Z, Chen PS. Chaos and the transition to ventricular fibrillation: a new approach to antiarrhythmic drug evaluation. Circulation. 1999 Jun 01; 99(21):2819-26. PMID: 10351978.
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    119. Hwang C, Karagueuzian HS, Chen PS. Idiopathic paroxysmal atrial fibrillation induced by a focal discharge mechanism in the left superior pulmonary vein: possible roles of the ligament of Marshall. J Cardiovasc Electrophysiol. 1999 May; 10(5):636-48. PMID: 10355919.
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    120. Hwang C, Karagueuzian HS, Czer L, Chen PS. Reentrant wavefronts in human ventricular tissue. J Cardiovasc Electrophysiol. 1999 Mar; 10(3):419. PMID: 10210507.
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    121. Uchida T, Yashima M, Gotoh M, Qu Z, Garfinkel A, Weiss JN, Fishbein MC, Mandel WJ, Chen PS, Karagueuzian HS. Mechanism of acceleration of functional reentry in the ventricle: effects of ATP-sensitive potassium channel opener. Circulation. 1999 Feb 09; 99(5):704-12. PMID: 9950670.
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    122. Karagueuzian HS, Chen PS. Graded response and restitution hypotheses of ventricular vulnerability to fibrillation: insights into the mechanism of initiation of fibrillation. J Electrocardiol. 1999; 32 Suppl:87-91. PMID: 10688308.
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    123. Karagueuzian HS, Athill CA, Yashima M, Ikeda T, Wu TJ, Mandel WJ, Chen PS. Transmembrane potential properties of atrial cells at different sites of a spiral wave reentry: cellular evidence for an excitable but nonexcited core. Pacing Clin Electrophysiol. 1998 Nov; 21(11 Pt 2):2360-5. PMID: 9825348.
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    124. Athill CA, Ikeda T, Kim YH, Wu TJ, Fishbein MC, Karagueuzian HS, Chen PS. Transmembrane potential properties at the core of functional reentrant wave fronts in isolated canine right atria. Circulation. 1998 Oct 13; 98(15):1556-67. PMID: 9769310.
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    125. Wu TJ, Yashima M, Xie F, Athill CA, Kim YH, Fishbein MC, Qu Z, Garfinkel A, Weiss JN, Karagueuzian HS, Chen PS. Role of pectinate muscle bundles in the generation and maintenance of intra-atrial reentry: potential implications for the mechanism of conversion between atrial fibrillation and atrial flutter. Circ Res. 1998 Aug 24; 83(4):448-62. PMID: 9721702.
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    126. Wu TJ, Ong JJ, Hwang C, Lee JJ, Fishbein MC, Czer L, Trento A, Blanche C, Kass RM, Mandel WJ, Karagueuzian HS, Chen PS. Characteristics of wave fronts during ventricular fibrillation in human hearts with dilated cardiomyopathy: role of increased fibrosis in the generation of reentry. J Am Coll Cardiol. 1998 Jul; 32(1):187-96. PMID: 9669269.
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    127. Kwan YY, Fan W, Hough D, Lee JJ, Fishbein MC, Karagueuzian HS, Chen PS. Effects of procainamide on wave-front dynamics during ventricular fibrillation in open-chest dogs. Circulation. 1998 May 12; 97(18):1828-36. PMID: 9603538.
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    128. Chen PS, Swerdlow CD, Hwang C, Karagueuzian HS. Current concepts of ventricular defibrillation. J Cardiovasc Electrophysiol. 1998 May; 9(5):553-62. PMID: 9607464.
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    129. Chen PS, Garfinkel A, Weiss JN, Karagueuzian HS. Computerized mapping of fibrillation in normal ventricular myocardium. Chaos. 1998 Mar; 8(1):127-136. PMID: 12779716.
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    130. Kim DT, Kwan Y, Lee JJ, Ikeda T, Uchida T, Kamjoo K, Kim YH, Ong JJ, Athill CA, Wu TJ, Czer L, Karagueuzian HS, Chen PS. Patterns of spiral tip motion in cardiac tissues. Chaos. 1998 Mar; 8(1):137-148. PMID: 12779717.
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    131. Chen PS, Wu TJ, Ikeda T, Ong JJ, Kim YH, Yashima M, Doshi R, Hwang C, Karagueuzian HS. Focal source hypothesis of atrial fibrillation. J Electrocardiol. 1998; 31 Suppl:32-4. PMID: 9988002.
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    132. Kim YH, Garfinkel A, Ikeda T, Wu TJ, Athill CA, Weiss JN, Karagueuzian HS, Chen PS. Spatiotemporal complexity of ventricular fibrillation revealed by tissue mass reduction in isolated swine right ventricle. Further evidence for the quasiperiodic route to chaos hypothesis. J Clin Invest. 1997 Nov 15; 100(10):2486-500. PMID: 9366563; PMCID: PMC508449.
    133. Ikeda T, Czer L, Trento A, Hwang C, Ong JJ, Hough D, Fishbein MC, Mandel WJ, Karagueuzian HS, Chen PS. Induction of meandering functional reentrant wave front in isolated human atrial tissues. Circulation. 1997 Nov 04; 96(9):3013-20. PMID: 9386170.
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    134. Ikeda T, Yashima M, Uchida T, Hough D, Fishbein MC, Mandel WJ, Chen PS, Karagueuzian HS. Attachment of meandering reentrant wave fronts to anatomic obstacles in the atrium. Role of the obstacle size. Circ Res. 1997 Nov; 81(5):753-64. PMID: 9351449.
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    135. Kamjoo K, Uchida T, Ikeda T, Fishbein MC, Garfinkel A, Weiss JN, Karagueuzian HS, Chen PS. Importance of location and timing of electrical stimuli in terminating sustained functional reentry in isolated swine ventricular tissues: evidence in support of a small reentrant circuit. Circulation. 1997 Sep 16; 96(6):2048-60. PMID: 9323098.
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    136. Ikeda T, Wu TJ, Uchida T, Hough D, Fishbein MC, Mandel WJ, Chen PS, Karagueuzian HS. Meandering and unstable reentrant wave fronts induced by acetylcholine in isolated canine right atrium. Am J Physiol. 1997 Jul; 273(1 Pt 2):H356-70. PMID: 9249511.
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    137. Gotoh M, Uchida T, Mandel WJ, Fishbein MC, Chen PS, Karagueuzian HS. Cellular graded responses and ventricular vulnerability to reentry by a premature stimulus in isolated canine ventricle. Circulation. 1997 Apr 15; 95(8):2141-54. PMID: 9133525.
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    138. Chen PS, Garfinkel A, Weiss JN, Karagueuzian HS. Spirals, chaos, and new mechanisms of wave propagation. Pacing Clin Electrophysiol. 1997 Feb; 20(2 Pt 2):414-21. PMID: 9058845.
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    139. Garfinkel A, Chen PS, Walter DO, Karagueuzian HS, Kogan B, Evans SJ, Karpoukhin M, Hwang C, Uchida T, Gotoh M, Nwasokwa O, Sager P, Weiss JN. Quasiperiodicity and chaos in cardiac fibrillation. J Clin Invest. 1997 Jan 15; 99(2):305-14. PMID: 9005999; PMCID: PMC507798.
    140. Gotoh M, Uchida T, Fan W, Fishbein MC, Karagueuzian HS, Chen PS. Anisotropic repolarization in ventricular tissue. Am J Physiol. 1997 Jan; 272(1 Pt 2):H107-13. PMID: 9038928.
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    141. Ikeda T, Uchida T, Hough D, Lee JJ, Fishbein MC, Mandel WJ, Chen PS, Karagueuzian HS. Mechanism of spontaneous termination of functional reentry in isolated canine right atrium. Evidence for the presence of an excitable but nonexcited core. Circulation. 1996 Oct 15; 94(8):1962-73. PMID: 8873675.
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    142. Lee JJ, Kamjoo K, Hough D, Hwang C, Fan W, Fishbein MC, Bonometti C, Ikeda T, Karagueuzian HS, Chen PS. Reentrant wave fronts in Wiggers' stage II ventricular fibrillation. Characteristics and mechanisms of termination and spontaneous regeneration. Circ Res. 1996 Apr; 78(4):660-75. PMID: 8635224.
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    143. Cha YM, Uchida T, Wolf PL, Peters BB, Fishbein MC, Karagueuzian HS, Chen PS. Effects of chemical subendocardial ablation on activation rate gradient during ventricular fibrillation. Am J Physiol. 1995 Dec; 269(6 Pt 2):H1998-2009. PMID: 8594909.
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    144. Ino T, Fishbein MC, Mandel WJ, Chen PS, Karagueuzian HS. Cellular mechanisms of ventricular bipolar electrograms showing double and fractionated potentials. J Am Coll Cardiol. 1995 Oct; 26(4):1080-9. PMID: 7560602.
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    145. Bonometti C, Hwang C, Hough D, Lee JJ, Fishbein MC, Karagueuzian HS, Chen PS. Interaction between strong electrical stimulation and reentrant wavefronts in canine ventricular fibrillation. Circ Res. 1995 Aug; 77(2):407-16. PMID: 7614724.
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    146. Fan W, Gotoh M, McCullen A, Karagueuzian HS, Chen PS. Reappraisal of effective refractory period testing. Am J Physiol. 1994 Jul; 267(1 Pt 2):H406-10. PMID: 8048606.
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    147. Karagueuzian HS, Khan SS, Hong K, Kobayashi Y, Denton T, Mandel WJ, Diamond GA. Action potential alternans and irregular dynamics in quinidine-intoxicated ventricular muscle cells. Implications for ventricular proarrhythmia. Circulation. 1993 May; 87(5):1661-72. PMID: 8491022.
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    148. Kobayashi Y, Gotoh M, Mandel WJ, Karagueuzian HS. Increased temporo-spatial dispersion of repolarization during double premature stimulation in the intact ventricle. Pacing Clin Electrophysiol. 1992 Nov; 15(11 Pt 2):2194-9. PMID: 1279624.
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    149. Karagueuzian HS, Khan SS, Denton TA, Gotoh M, Mandel WJ, Diamond GA. Phase plane plot of electrograms as a marker of ventricular electrical instability during acute ischemia: initial experimental results and potential clinical applications. Pacing Clin Electrophysiol. 1992 Nov; 15(11 Pt 2):2188-93. PMID: 1279623.
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    150. Kobayashi Y, Peters W, Khan SS, Mandel WJ, Karagueuzian HS. Cellular mechanisms of differential action potential duration restitution in canine ventricular muscle cells during single versus double premature stimuli. Circulation. 1992 Sep; 86(3):955-67. PMID: 1516208.
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    151. Denton TA, Diamond GA, Khan SS, Karagueuzian H. Can the techniques of nonlinear dynamics detect chaotic behavior in electrocardiographic signals? J Electrocardiol. 1992; 24 Suppl:84-90. PMID: 1552275.
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    152. Karagueuzian HS, Kogan BY, Khan SS, Denton TA, Karplus WJ, Mandel WJ, Diamond GA. Induction of cellular chaos during quinidine toxicity. Predictive power of nonlinear dynamic analysis for drug-induced proarrhythmia--a hypothesis. J Electrocardiol. 1992; 24 Suppl:91-6. PMID: 1552276.
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    153. Kogan BY, Karplus WJ, Billett BS, Pang AT, Khan SS, Mandel WJ, Karagueuzian HS. The role of diastolic outward current deactivation kinetics on the induction of spiral waves. Pacing Clin Electrophysiol. 1991 Nov; 14(11 Pt 2):1688-93. PMID: 1721159.
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    154. Peters W, Gang ES, Okazaki H, Solingen S, Kobayashi Y, Karagueuzian HS, Mandel WJ. Acute effects of intravenous propafenone on the internal ventricular defibrillation threshold in the anesthetized dog. Am Heart J. 1991 Nov; 122(5):1355-60. PMID: 1951000.
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    155. Meesmann M, Karagueuzian HS, Ino T, McGrath MF, Mandel WJ. The role of enhanced vagal activity on ischemic ventricular tachycardia: pharmacologic basis of inefficiency. Am Heart J. 1991 Jun; 121(6 Pt 1):1703-13. PMID: 1674635.
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    156. Karagueuzian HS, Khan SS, Peters W, Mandel WJ, Diamond GA. Nonhomogeneous local atrial activity during acute atrial fibrillation: spectral and dynamic analysis. Pacing Clin Electrophysiol. 1990 Dec; 13(12 Pt 2):1937-42. PMID: 1704571.
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    157. Karagueuzian HS, Khan SS, Mandel WJ, Hong K, Diamond GA. Nonlinear dynamic analysis of temporally heterogeneous action potential characteristics. Pacing Clin Electrophysiol. 1990 Dec; 13(12 Pt 2):2113-8. PMID: 1704604.
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    158. Denton TA, Diamond GA, Helfant RH, Khan S, Karagueuzian H. Fascinating rhythm: a primer on chaos theory and its application to cardiology. Am Heart J. 1990 Dec; 120(6 Pt 1):1419-40. PMID: 2248188.
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    159. Ino T, Karagueuzian HS, Hong K, Meesmann M, Mandel WJ, Peter T. Relation of monophasic action potential recorded with contact electrode to underlying transmembrane action potential properties in isolated cardiac tissues: a systematic microelectrode validation study. Cardiovasc Res. 1988 Apr; 22(4):255-64. PMID: 3197056.
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    160. Gang ES, Peter T, Nalos PC, Meesmann M, Karagueuzian HS, Mandel WJ, Oseran DS, Myers MR. Subthreshold atrial pacing in patients with a left-sided accessory pathway: an effective new method for terminating reciprocating tachycardia. J Am Coll Cardiol. 1988 Mar; 11(3):515-21. PMID: 3343454.
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    161. Gang ES, Peter T, Karagueuzian HS, Mandel WJ, Meesmann M. Decline in ventricular fibrillation threshold after successive premature extrastimuli: a possible explantation for the induction of ventricular fibrillation during programmed stimulation with multiple extrastimuli. Cardiovasc Res. 1987 Nov; 21(11):790-5. PMID: 3370663.
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    162. Meesmann M, Karagueuzian HS, Ino T, McGrath MF, Fishbein MC, Mandel WJ, Peter T. Selective perfusion of ischemic myocardium during coronary venous retroinjection: a study of the causative role of venoarterial and venoventricular pressure gradients. J Am Coll Cardiol. 1987 Oct; 10(4):887-97. PMID: 3655153.
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    163. Sugi K, Karagueuzian HS, Fishbein MC, Mandel WJ, Peter T. Cellular electrophysiologic characteristics of surviving subendocardial fibers in chronically infarcted right ventricular myocardium susceptible to inducible sustained ventricular tachycardia. Am Heart J. 1987 Sep; 114(3):559-69. PMID: 3630897.
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    164. Siegel RJ, Fealy M, Edwalds G, Karagueuzian H, Fishbein MC. Immunohistochemical localization of procainamide in normal, ischemic, and necrotic canine myocardium during acute experimental myocardial infarction. Am Heart J. 1987 Jun; 113(6):1383-9. PMID: 3591607.
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    165. Katoh T, Karagueuzian HS, Sugi K, Ohta M, Mandel WJ, Peter T. Effects of propafenone on sinus nodal and ventricular automaticity: in vitro and in vivo correlation. Am Heart J. 1987 Apr; 113(4):941-52. PMID: 3565244.
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    166. Ohta M, Karagueuzian HS, Mandel WJ, Peter T. Acute and chronic effects of amiodarone on delayed afterdepolarization and triggered automaticity in rabbit ventricular myocardium. Am Heart J. 1987 Feb; 113(2 Pt 1):289-96. PMID: 3812180.
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    167. Karagueuzian HS, Sugi K, Ohta M, Meesmann M, Ino T, Peter T, Mandel WJ. The efficacy of cibenzoline and propafenone against inducible sustained and nonsustained ventricular tachycardias in conscious dogs with isolated chronic right ventricular infarction: a comparative study with procainamide. Am Heart J. 1986 Dec; 112(6):1173-83. PMID: 3788764.
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    168. Karagueuzian HS, Sugi K, Ohta M, Fishbein MC, Mandel WJ, Peter T. Inducible sustained ventricular tachycardia and ventricular fibrillation in conscious dogs with isolated right ventricular infarction: relation to infarct structure. J Am Coll Cardiol. 1986 Apr; 7(4):850-8. PMID: 3958343.
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    169. Karagueuzian HS, Ohta M, Drury JK, Fishbein MC, Meerbaum S, Corday E, Mandel WJ, Peter T. Coronary venous retroinfusion of procainamide: a new approach for the management of spontaneous and inducible sustained ventricular tachycardia during myocardial infarction. J Am Coll Cardiol. 1986 Mar; 7(3):551-63. PMID: 3950235.
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    170. Karagueuzian HS, Sugi K, Ohta M, Mandel WJ, Peter T. The efficacy of lidocaine and verapamil alone and in combination on spontaneously occurring automatic ventricular tachycardia in conscious dogs one day after right coronary artery occlusion. Am Heart J. 1986 Mar; 111(3):438-46. PMID: 3953350.
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    171. Mandel WJ, Karagueuzian HS, Peter T. Internal medicine: new antiarrhythmic agents-amiodarone, mexiletine, tocainide. West J Med. 1985 Jul; 143(1):96-7. PMID: 18749804.
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    172. Karagueuzian HS, Jordan JL, Sugi K, Ohta M, Gang E, Peter T, Mandel WJ. Appropriate diagnostic studies for sinus node dysfunction. Pacing Clin Electrophysiol. 1985 Mar; 8(2):242-54. PMID: 2580286.
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    173. Sugi K, Karagueuzian HS, Fishbein MC, McCullen A, Sato Y, Ganz W, Mandel WJ, Peter T. Spontaneous ventricular tachycardia associated with isolated right ventricular infarction, one day after right coronary artery occlusion in the dog: studies on the site of origin and mechanism. Am Heart J. 1985 Feb; 109(2):232-44. PMID: 3966341.
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    174. Hamer AW, Karagueuzian HS, Sugi K, Zaher CA, Mandel WJ, Peter T. Factors related to the induction of ventricular fibrillation in the normal canine heart by programmed electrical stimulation. J Am Coll Cardiol. 1984 Mar; 3(3):751-9. PMID: 6693647.
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    175. Karagueuzian HS, Katoh T, McCullen A, Mandel WJ, Peter T. Electrophysiologic and hemodynamic effects of propafenone, a new antiarrhythmic agent, on the anesthetized, closed-chest dog: comparative study with lidocaine. Am Heart J. 1984 Mar; 107(3):418-24. PMID: 6695682.
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    176. Karagueuzian HS, Fujimoto T, Katoh T, Peter T, McCullen A, Mandel WJ. Suppression of ventricular arrhythmias by propafenone, a new antiarrhythmic agent, during acute myocardial infarction in the conscious dog. A comparative study with lidocaine. Circulation. 1982 Dec; 66(6):1190-8. PMID: 7139897.
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    177. Katoh T, Karagueuzian HS, Jordan J, Mandel WJ. The cellular electrophysiologic mechanism of the dual actions of disopyramide on rabbit sinus node function. Circulation. 1982 Dec; 66(6):1216-24. PMID: 7139900.
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    178. Karagueuzian HS, Katzung BG. Voltage-clamp studies of transient inward current and mechanical oscillations induced by ouabain in ferret papillary muscle. J Physiol. 1982 Jun; 327:255-71. PMID: 7120138; PMCID: PMC1225107.
    179. Karagueuzian HS, Pennec JP, Deroubaix E, de Leiris J, Coraboeuf E. Effects of excess free fatty acids on the electrophysiological properties of ventricular specialized conducting tissue: a comparative study between the sheep and the dog. J Cardiovasc Pharmacol. 1982 May-Jun; 4(3):462-8. PMID: 6177944.
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    180. Clusin WT, Bristow MR, Karagueuzian HS, Katzung BG, Schroeder JS. Do calcium-dependent ionic currents mediate ischemic ventricular fibrillation? Am J Cardiol. 1982 Feb 18; 49(3):606-12. PMID: 6277181.
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    181. Karagueuzian HS, Katzung BG. Relative inotropic and arrhythmogenic effects of five cardiac steroids in ventricular myocardium: oscillatory afterpotentials and the role of endogenous catecholamines. J Pharmacol Exp Ther. 1981 Aug; 218(2):348-56. PMID: 6114168.
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    182. Karagueuzian HS, Katzung BG. Ionic basis of digitalis toxicity in mammalian ventricle: demonstration of transient inward current. Proc West Pharmacol Soc. 1980; 23:281-4. PMID: 7403145.
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    183. Gauduel Y, Karagueuzian HS, de Leiris J. Deleterious effects of endogenous catecholamines on hypoxic myocardial cells following reoxygenation. J Mol Cell Cardiol. 1979 Aug; 11(8):717-31. PMID: 490652.
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