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Feldman Jack

TitleDistinguished Professor
InstitutionUniversity of California Los Angeles
DepartmentNeurobiology
AddressCHS
Los Angeles CA 90095
Phone(310) 825-1586
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    Collapse Research 
    Collapse Research Activities and Funding
    Neural basis for positive effects of breathing on emotional state
    NIH/NCCIH R21AT009034Jan 5, 2018 - Dec 31, 2019
    Role: Principal Investigator
    Neural control of breathing
    NIH/NHLBI R35HL135779Jan 11, 2017 - Dec 31, 2023
    Role: Principal Investigator
    Functional Dissection of Medullary Respiratory Microcircuits
    NIH/NINDS R01NS072211Aug 15, 2010 - Mar 31, 2021
    Role: Principal Investigator
    Role of Dendritic Ca2+ Transients in Respiratory Rhythm Generation
    NIH/NHLBI R21HL097199Sep 1, 2009 - Aug 31, 2012
    Role: Principal Investigator
    Functional dissection of preBotzinger Complex neuronal circuits
    NIH/NHLBI R21HL094811Dec 15, 2008 - Nov 30, 2010
    Role: Principal Investigator
    Training Program in Neural Microcircuits
    NIH/NINDS T32NS058280Jul 1, 2007 - Jun 30, 2017
    Role: Principal Investigator
    Generation of Respiratory Rhythm
    NIH/NHLBI R01HL070029Apr 1, 2002 - Jun 30, 2017
    Role: Principal Investigator
    DESCENDING CONTROL OF SYMPATHETIC PREGANGLIONIC NEURONS
    NIH/NINDS R01NS028805Aug 1, 1990 - Jul 31, 1994
    Role: Principal Investigator
    Respiratory Pattern Generation Studied In Vitro
    NIH/NHLBI R01HL040959Jul 1, 1988 - Mar 31, 2018
    Role: Principal Investigator
    Functional Plasticity in Hypoglossal Motoneurons
    NIH/NINDS R01NS024742Sep 1, 1986 - Jun 30, 2010
    Role: Principal Investigator
    RESPIRATORY PATTERN GENERATION
    NIH/NHLBI R37HL037941Jul 1, 1986 - Nov 30, 2001
    Role: Principal Investigator
    RESPIRATORY PATTERN GENERATION
    NIH/NHLBI R01HL037941Jul 1, 1986 - Nov 30, 1990
    Role: Principal Investigator
    PHARMACOLOGY OF BRAINSTEM RESPIRATORY NEURONS
    NIH/NINDS R01NS021036Sep 1, 1984 - Aug 31, 1986
    Role: Principal Investigator
    RESPIRATORY PATTERN GENERATION
    NIH/NHLBI R01HL023820Apr 1, 1979 - Jun 30, 1986
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Shao XM, Liu S, Lee ES, Fung D, Pei H, Liang J, Mudgway R, Zhang J, Feldman JL, Zhu Y, Louie S, Xie XS. Chronic intermittent nicotine delivery via lung alveolar region-targeted aerosol technology produces circadian pharmacokinetics in rats resembling human smokers. J Appl Physiol (1985). 2018 Sep 20. PMID: 30236046.
      View in: PubMed
    2. Huckstepp RTR, Cardoza KP, Henderson LE, Feldman JL. Distinct parafacial regions in control of breathing in adult rats. PLoS One. 2018; 13(8):e0201485. PMID: 30096151.
      View in: PubMed
    3. Del Negro CA, Funk GD, Feldman JL. Breathing matters. Nat Rev Neurosci. 2018 May 08. PMID: 29740175.
      View in: PubMed
    4. Yang CF, Feldman JL. Efferent projections of excitatory and inhibitory preBötzinger Complex neurons. J Comp Neurol. 2018 Jun 01; 526(8):1389-1402. PMID: 29473167.
      View in: PubMed
    5. Shao XM, López-Valdés HE, Liang J, Feldman JL. Inhaled nicotine equivalent to cigarette smoking disrupts systemic and uterine hemodynamics and induces cardiac arrhythmia in pregnant rats. Sci Rep. 2017 Dec 05; 7(1):16974. PMID: 29209071.
      View in: PubMed
    6. Yackle K, Schwarz LA, Kam K, Sorokin JM, Huguenard JR, Feldman JL, Luo L, Krasnow MA. Breathing control center neurons that promote arousal in mice. Science. 2017 03 31; 355(6332):1411-1415. PMID: 28360327.
      View in: PubMed
    7. Cui Y, Kam K, Sherman D, Janczewski WA, Zheng Y, Feldman JL. Defining preBötzinger Complex Rhythm- and Pattern-Generating Neural Microcircuits In Vivo. Neuron. 2016 Aug 03; 91(3):602-14. PMID: 27497222.
      View in: PubMed
    8. Huckstepp RT, Henderson LE, Cardoza KP, Feldman JL. Interactions between respiratory oscillators in adult rats. Elife. 2016 06 14; 5. PMID: 27300271; PMCID: PMC4907693.
    9. Li P, Janczewski WA, Yackle K, Kam K, Pagliardini S, Krasnow MA, Feldman JL. The peptidergic control circuit for sighing. Nature. 2016 Feb 18; 530(7590):293-297. PMID: 26855425; PMCID: PMC4852886.
    10. Sherman D, Worrell JW, Cui Y, Feldman JL. Optogenetic perturbation of preBötzinger complex inhibitory neurons modulates respiratory pattern. Nat Neurosci. 2015 Mar; 18(3):408-14. PMID: 25643296; PMCID: PMC4340826.
    11. Huckstepp RT, Cardoza KP, Henderson LE, Feldman JL. Role of parafacial nuclei in control of breathing in adult rats. J Neurosci. 2015 Jan 21; 35(3):1052-67. PMID: 25609622; PMCID: PMC4300318.
    12. Feldman JL, Kam K. Facing the challenge of mammalian neural microcircuits: taking a few breaths may help. J Physiol. 2015 Jan 01; 593(1):3-23. PMID: 25556783.
      View in: PubMed
    13. Kam K, Worrell JW, Janczewski WA, Cui Y, Feldman JL. Distinct inspiratory rhythm and pattern generating mechanisms in the preBötzinger complex. J Neurosci. 2013 May 29; 33(22):9235-45. PMID: 23719793; PMCID: PMC3737080.
    14. Janczewski WA, Tashima A, Hsu P, Cui Y, Feldman JL. Role of inhibition in respiratory pattern generation. J Neurosci. 2013 Mar 27; 33(13):5454-65. PMID: 23536061; PMCID: PMC3724454.
    15. Kam K, Worrell JW, Ventalon C, Emiliani V, Feldman JL. Emergence of population bursts from simultaneous activation of small subsets of preBötzinger complex inspiratory neurons. J Neurosci. 2013 Feb 20; 33(8):3332-8. PMID: 23426661; PMCID: PMC3708687.
    16. Shao XM, Xu B, Liang J, Xie XS, Zhu Y, Feldman JL. Nicotine delivery to rats via lung alveolar region-targeted aerosol technology produces blood pharmacokinetics resembling human smoking. Nicotine Tob Res. 2013 Jul; 15(7):1248-58. PMID: 23239844; PMCID: PMC3682843.
    17. Feldman JL, Del Negro CA, Gray PA. Understanding the rhythm of breathing: so near, yet so far. Annu Rev Physiol. 2013; 75:423-52. PMID: 23121137; PMCID: PMC3671763.
    18. Babiec WE, Faull KF, Feldman JL. Cyclothiazide-induced persistent increase in respiratory-related activity in vitro. J Physiol. 2012 Oct 01; 590(19):4897-915. PMID: 22753547; PMCID: PMC3487044.
    19. Tan W, Sherman D, Turesson J, Shao XM, Janczewski WA, Feldman JL. Reelin demarcates a subset of pre-Bötzinger complex neurons in adult rat. J Comp Neurol. 2012 Feb 15; 520(3):606-19. PMID: 21858819; PMCID: PMC3751584.
    20. Pagliardini S, Janczewski WA, Tan W, Dickson CT, Deisseroth K, Feldman JL. Active expiration induced by excitation of ventral medulla in adult anesthetized rats. J Neurosci. 2011 Feb 23; 31(8):2895-905. PMID: 21414911; PMCID: PMC3142740.
    21. Feldman JL. Chapter 14--looking forward to breathing. Prog Brain Res. 2011; 188:213-8. PMID: 21333812.
      View in: PubMed
    22. Schwab DJ, Bruinsma RF, Feldman JL, Levine AJ. Rhythmogenic neuronal networks, emergent leaders, and k-cores. Phys Rev E Stat Nonlin Soft Matter Phys. 2010 Nov; 82(5 Pt 1):051911. PMID: 21230504; PMCID: PMC3477876.
    23. Saywell SA, Babiec WE, Neverova NV, Feldman JL. Protein kinase G-dependent mechanisms modulate hypoglossal motoneuronal excitability and long-term facilitation. J Physiol. 2010 Nov 15; 588(Pt 22):4431-9. PMID: 20855434; PMCID: PMC3008849.
    24. Tan W, Pagliardini S, Yang P, Janczewski WA, Feldman JL. Projections of preBötzinger complex neurons in adult rats. J Comp Neurol. 2010 May 15; 518(10):1862-78. PMID: 20235095; PMCID: PMC3494295.
    25. Morgado-Valle C, Baca SM, Feldman JL. Glycinergic pacemaker neurons in preBötzinger complex of neonatal mouse. J Neurosci. 2010 Mar 10; 30(10):3634-9. PMID: 20219997; PMCID: PMC2947441.
    26. Del Negro CA, Hayes JA, Pace RW, Brush BR, Teruyama R, Feldman JL. Synaptically activated burst-generating conductances may underlie a group-pacemaker mechanism for respiratory rhythm generation in mammals. Prog Brain Res. 2010; 187:111-36. PMID: 21111204; PMCID: PMC3370336.
    27. Feldman JL, Kam K, Janczewski WA. Practice makes perfect, even for breathing. Nat Neurosci. 2009 Aug; 12(8):961-3. PMID: 19636348; PMCID: PMC2810466.
    28. Shao XM, Feldman JL. Central cholinergic regulation of respiration: nicotinic receptors. Acta Pharmacol Sin. 2009 Jun; 30(6):761-70. PMID: 19498418; PMCID: PMC4002383.
    29. Del Negro CA, Kam K, Hayes JA, Feldman JL. Asymmetric control of inspiratory and expiratory phases by excitability in the respiratory network of neonatal mice in vitro. J Physiol. 2009 Mar 15; 587(Pt 6):1217-31. PMID: 19171658; PMCID: PMC2674993.
    30. Morgado-Valle C, Beltran-Parrazal L, DiFranco M, Vergara JL, Feldman JL. Somatic Ca2+ transients do not contribute to inspiratory drive in preBötzinger Complex neurons. J Physiol. 2008 Sep 15; 586(18):4531-40. PMID: 18635649; PMCID: PMC2614019.
    31. McKay LC, Feldman JL. Unilateral ablation of pre-Botzinger complex disrupts breathing during sleep but not wakefulness. Am J Respir Crit Care Med. 2008 Jul 01; 178(1):89-95. PMID: 18420958; PMCID: PMC2441928.
    32. Tan W, Janczewski WA, Yang P, Shao XM, Callaway EM, Feldman JL. Silencing preBötzinger complex somatostatin-expressing neurons induces persistent apnea in awake rat. Nat Neurosci. 2008 May; 11(5):538-40. PMID: 18391943; PMCID: PMC2515565.
    33. Shao XM, Tan W, Xiu J, Puskar N, Fonck C, Lester HA, Feldman JL. Alpha4* nicotinic receptors in preBotzinger complex mediate cholinergic/nicotinic modulation of respiratory rhythm. J Neurosci. 2008 Jan 09; 28(2):519-28. PMID: 18184794; PMCID: PMC3477875.
    34. Pace RW, Mackay DD, Feldman JL, Del Negro CA. Inspiratory bursts in the preBötzinger complex depend on a calcium-activated non-specific cation current linked to glutamate receptors in neonatal mice. J Physiol. 2007 Jul 01; 582(Pt 1):113-25. PMID: 17446214; PMCID: PMC2075310.
    35. Morgado-Valle C, Feldman JL. NMDA receptors in preBotzinger complex neurons can drive respiratory rhythm independent of AMPA receptors. J Physiol. 2007 Jul 01; 582(Pt 1):359-68. PMID: 17446224; PMCID: PMC2075291.
    36. Neverova NV, Saywell SA, Nashold LJ, Mitchell GS, Feldman JL. Episodic stimulation of alpha1-adrenoreceptors induces protein kinase C-dependent persistent changes in motoneuronal excitability. J Neurosci. 2007 Apr 18; 27(16):4435-42. PMID: 17442828.
      View in: PubMed
    37. Pace RW, Mackay DD, Feldman JL, Del Negro CA. Role of persistent sodium current in mouse preBötzinger Complex neurons and respiratory rhythm generation. J Physiol. 2007 Apr 15; 580(Pt. 2):485-96. PMID: 17272351; PMCID: PMC2075543.
    38. Shao XM, Feldman JL. Efficient measurement of endogenous neurotransmitters in small localized regions of central nervous systems in vitro with HPLC. J Neurosci Methods. 2007 Mar 15; 160(2):256-63. PMID: 17092561; PMCID: PMC2441908.
    39. Shao XM, Feldman JL. Micro-agar salt bridge in patch-clamp electrode holder stabilizes electrode potentials. J Neurosci Methods. 2007 Jan 15; 159(1):108-15. PMID: 16916545; PMCID: PMC4340483.
    40. Feldman JL, Janczewski WA. Point:Counterpoint: The parafacial respiratory group (pFRG)/pre-Botzinger complex (preBotC) is the primary site of respiratory rhythm generation in the mammal. Counterpoint: the preBötC is the primary site of respiratory rhythm generation in the mammal. J Appl Physiol (1985). 2006 Jun; 100(6):2096-7; discussion 2097-8, 2103-8. PMID: 16767809.
      View in: PubMed
    41. Feldman JL, Janczewski WA. The Last Word: Point:Counterpoint authors respond to commentaries on "the parafacial respiratory group (pFRG)/pre-Botzinger complex (preBotC) is the primary site of respiratory rhythm generation in the mammal". J Appl Physiol (1985). 2006 Aug; 101(2):689. PMID: 16709655.
      View in: PubMed
    42. Janczewski WA, Feldman JL. Novel data supporting the two respiratory rhythm oscillator hypothesis. Focus on "respiration-related rhythmic activity in the rostral medulla of newborn rats". J Neurophysiol. 2006 Jul; 96(1):1-2. PMID: 16554514.
      View in: PubMed
    43. Feldman JL, Del Negro CA. Looking for inspiration: new perspectives on respiratory rhythm. Nat Rev Neurosci. 2006 Mar; 7(3):232-42. PMID: 16495944; PMCID: PMC2819067.
    44. Janczewski WA, Feldman JL. Distinct rhythm generators for inspiration and expiration in the juvenile rat. J Physiol. 2006 Jan 15; 570(Pt 2):407-20. PMID: 16293645; PMCID: PMC1464316.
    45. McKay LC, Janczewski WA, Feldman JL. Sleep-disordered breathing after targeted ablation of preBötzinger complex neurons. Nat Neurosci. 2005 Sep; 8(9):1142-4. PMID: 16116455; PMCID: PMC2819071.
    46. Feldman JL, Neverova NV, Saywell SA. Modulation of hypoglossal motoneuron excitability by intracellular signal transduction cascades. Respir Physiol Neurobiol. 2005 Jul 28; 147(2-3):131-43. PMID: 15893504.
      View in: PubMed
    47. Del Negro CA, Morgado-Valle C, Hayes JA, Mackay DD, Pace RW, Crowder EA, Feldman JL. Sodium and calcium current-mediated pacemaker neurons and respiratory rhythm generation. J Neurosci. 2005 Jan 12; 25(2):446-53. PMID: 15647488.
      View in: PubMed
    48. Feldman JL, Janczewski WA. Slip of the tongue. Am J Respir Crit Care Med. 2004 Sep 15; 170(6):581-2. PMID: 15355870.
      View in: PubMed
    49. McKay LC, Janczewski WA, Feldman JL. Episodic hypoxia evokes long-term facilitation of genioglossus muscle activity in neonatal rats. J Physiol. 2004 May 15; 557(Pt 1):13-8. PMID: 15047768; PMCID: PMC1665035.
    50. Bocchiaro CM, Feldman JL. Synaptic activity-independent persistent plasticity in endogenously active mammalian motoneurons. Proc Natl Acad Sci U S A. 2004 Mar 23; 101(12):4292-5. PMID: 15024116; PMCID: PMC384734.
    51. Mellen NM, Roham M, Feldman JL. Afferent modulation of neonatal rat respiratory rhythm in vitro: cellular and synaptic mechanisms. J Physiol. 2004 May 01; 556(Pt 3):859-74. PMID: 14766932; PMCID: PMC1664991.
    52. Morgado-Valle C, Feldman JL. Depletion of substance P and glutamate by capsaicin blocks respiratory rhythm in neonatal rat in vitro. J Physiol. 2004 Mar 16; 555(Pt 3):783-92. PMID: 14724197; PMCID: PMC1664860.
    53. Saywell SA, Feldman JL. Dynamic interactions of excitatory and inhibitory inputs in hypoglossal motoneurones: respiratory phasing and modulation by PKA. J Physiol. 2004 Feb 01; 554(Pt 3):879-89. PMID: 14660708; PMCID: PMC1664783.
    54. Parkis MA, Feldman JL, Robinson DM, Funk GD. Oscillations in endogenous inputs to neurons affect excitability and signal processing. J Neurosci. 2003 Sep 03; 23(22):8152-8. PMID: 12954878.
      View in: PubMed
    55. Mellen NM, Janczewski WA, Bocchiaro CM, Feldman JL. Opioid-induced quantal slowing reveals dual networks for respiratory rhythm generation. Neuron. 2003 Mar 06; 37(5):821-6. PMID: 12628172; PMCID: PMC3210017.
    56. Bocchiaro CM, Saywell SA, Feldman JL. Dynamic modulation of inspiratory drive currents by protein kinase A and protein phosphatases in functionally active motoneurons. J Neurosci. 2003 Feb 15; 23(4):1099-103. PMID: 12598595.
      View in: PubMed
    57. Feldman JL, Mitchell GS, Nattie EE. Breathing: rhythmicity, plasticity, chemosensitivity. Annu Rev Neurosci. 2003; 26:239-66. PMID: 12598679; PMCID: PMC2811316.
    58. Shao XM, Ge Q, Feldman JL. Modulation of AMPA receptors by cAMP-dependent protein kinase in preBötzinger complex inspiratory neurons regulates respiratory rhythm in the rat. J Physiol. 2003 Mar 01; 547(Pt 2):543-53. PMID: 12562968; PMCID: PMC2342649.
    59. Janczewski WA, Onimaru H, Homma I, Feldman JL. Opioid-resistant respiratory pathway from the preinspiratory neurones to abdominal muscles: in vivo and in vitro study in the newborn rat. J Physiol. 2002 Dec 15; 545(Pt 3):1017-26. PMID: 12482904; PMCID: PMC2290709.
    60. Shao XM, Feldman JL. Pharmacology of nicotinic receptors in preBötzinger complex that mediate modulation of respiratory pattern. J Neurophysiol. 2002 Oct; 88(4):1851-8. PMID: 12364511; PMCID: PMC4337837.
    61. Del Negro CA, Morgado-Valle C, Feldman JL. Respiratory rhythm: an emergent network property? Neuron. 2002 May 30; 34(5):821-30. PMID: 12062027.
      View in: PubMed
    62. Mellen NM, Milsom WK, Feldman JL. Hypothermia and recovery from respiratory arrest in a neonatal rat in vitro brain stem preparation. Am J Physiol Regul Integr Comp Physiol. 2002 Feb; 282(2):R484-91. PMID: 11792658.
      View in: PubMed
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