Weiss James

InstitutionUniversity of California Los Angeles
AddressDavid Geffen School of Medicine at UCLA
675 S. Charles Young Drive
MRL Bldg 3645
Los Angeles CA 90095
Phone(310) 825-8811
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    Other Positions


    Collapse Research 
    Collapse Research Activities and Funding
    Systems Approach to Unraveling the Genetic Basis of Heart Failure
    NIH/NHLBI R01HL114437Sep 4, 2013 - May 31, 2017
    Role: Principal Investigator
    Hexokinases and Cardioprotection
    NIH/NHLBI R01HL117385Aug 12, 2013 - May 31, 2017
    Role: Principal Investigator
    2011 Cardiac Arrhythmia Mechanisms Gordon Research Conference
    NIH/NHLBI R13HL108483Feb 13, 2011 - Aug 1, 2011
    Role: Principal Investigator
    Afterdepolarizations and Cardiac Arrhythmias
    NIH/NHLBI R01HL103662Jul 1, 2010 - May 31, 2011
    Role: Principal Investigator
    Mitochondrial pathways in NO induced cardioprotection
    NIH/NHLBI R01HL101228May 1, 2010 - Mar 31, 2014
    Role: Co-Principal Investigator
    Metabolic Oscillations in Heart
    NIH/NHLBI R01HL095663Jul 1, 2009 - Jun 30, 2011
    Role: Co-Principal Investigator
    Cardiac Fibrillation: Mechanisms and Therapy
    NIH/NHLBI P01HL078931Jan 1, 2005 - May 31, 2016
    Role: Principal Investigator
    Mitochondria and Cardiac Cell Death
    NIH/NHLBI R01HL071870Jun 5, 2004 - May 31, 2008
    Role: Principal Investigator
    Cardiovascular Scientist Training Program
    NIH/NHLBI T32HL007895Jul 1, 1998 - Jun 30, 2019
    Role: Principal Investigator
    Properties of Inward Rectifier K Channels
    NIH/NHLBI R37HL060025Jun 1, 1998 - Jun 30, 2008
    Role: Principal Investigator
    NIH/NHLBI P50HL052319Feb 1, 1995 - Dec 31, 2005
    Role: Principal Investigator
    NIH/NHLBI R01HL044880Jul 1, 1990 - Nov 30, 1998
    Role: Principal Investigator
    NIH/NHLBI K04HL001890Jan 1, 1987 - Dec 31, 1991
    Role: Principal Investigator
    NIH/NHLBI R01HL036729Jul 1, 1986 - May 31, 1998
    Role: Principal Investigator
    NIH/NHLBI R23HL027846Dec 1, 1983 - Nov 30, 1986
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Chen M, Xu DZ, Wu AZ, Guo S, Wan J, Yin D, Lin SF, Chen Z, Rubart-von der Lohe M, Everett TH, Qu Z, Weiss JN, Chen PS. Concomitant SK current activation and sodium current inhibition cause J wave syndrome. JCI Insight. 2018 Nov 15; 3(22). PMID: 30429367.
      View in: PubMed
    2. Wan J, Chen M, Wang Z, Everett TH, Rubart-von der Lohe M, Shen C, Qu Z, Weiss JN, Boyden PA, Chen PS. The Small Conductance Calcium Activated Potassium Current Modulates the Ventricular Escape Rhythm in Normal Rabbit Hearts. Heart Rhythm. 2018 Nov 01. PMID: 30445170.
      View in: PubMed
    3. Rees CM, Yang JH, Santolini M, Lusis AJ, Weiss JN, Karma A. The Ca2+ transient as a feedback sensor controlling cardiomyocyte ionic conductances in mouse populations. Elife. 2018 Sep 25; 7. PMID: 30251624.
      View in: PubMed
    4. Chen M, Yin D, Guo S, Xu DZ, Wang Z, Chen Z, Rubart-von der Lohe M, Lin SF, Everett TH, Weiss JN, Chen PS. Sex-Specific Activation of SK Current by Isoproterenol Facilitates Action Potential Triangulation and Arrhythmogenesis in Rabbit Ventricles. J Physiol. 2018 Jun 19. PMID: 29917243.
      View in: PubMed
    5. Pezhouman A, Cao H, Fishbein MC, Belardinelli L, Weiss JN, Karagueuzian HS. Atrial Fibrillation Initiated by Early Afterdepolarization-Mediated Triggered Activity during Acute Oxidative Stress: Efficacy of Late Sodium Current Blockade. J Heart Health. 2018 Apr 25; 4(1). PMID: 30393761.
      View in: PubMed
    6. Restrepo JG, Weiss JN, Karma A. Calsequestrin-Mediated Mechanism for Cellular Calcium Transient Alternans. Biophys J. 2018 Apr 24; 114(8):2024-2025. PMID: 29694878.
      View in: PubMed
    7. Santolini M, Romay MC, Yukhtman CL, Rau CD, Ren S, Saucerman JJ, Wang JJ, Weiss JN, Wang Y, Lusis AJ, Karma A. A personalized, multiomics approach identifies genes involved in cardiac hypertrophy and heart failure. NPJ Syst Biol Appl. 2018; 4:12. PMID: 29507758.
      View in: PubMed
    8. Yin D, Chen M, Yang N, Wu AZ, Xu D, Tsai WC, Yuan Y, Tian Z, Chan YH, Shen C, Chen Z, Lin SF, Weiss JN, Chen PS, Everett TH. Role of apamin-sensitive small conductance calcium-activated potassium currents in long-term cardiac memory in rabbits. Heart Rhythm. 2018 May; 15(5):761-769. PMID: 29325977.
      View in: PubMed
    9. Calmettes G, Weiss JN. The emergence of egalitarianism in a model of early human societies. Heliyon. 2017 Nov; 3(11):e00451. PMID: 29264410.
      View in: PubMed
    10. Ko CY, Liu MB, Song Z, Qu Z, Weiss JN. Multiscale Determinants of Delayed Afterdepolarization Amplitude in Cardiac Tissue. Biophys J. 2017 May 09; 112(9):1949-1961. PMID: 28494965.
      View in: PubMed
    11. Korge P, Calmettes G, John SA, Weiss JN. Reactive oxygen species production induced by pore opening in cardiac mitochondria: The role of complex III. J Biol Chem. 2017 06 16; 292(24):9882-9895. PMID: 28450391.
      View in: PubMed
    12. Korge P, John SA, Calmettes G, Weiss JN. Reactive oxygen species production induced by pore opening in cardiac mitochondria: The role of complex II. J Biol Chem. 2017 06 16; 292(24):9896-9905. PMID: 28450394.
      View in: PubMed
    13. Landaw J, Garfinkel A, Weiss JN, Qu Z. Memory-Induced Chaos in Cardiac Excitation. Phys Rev Lett. 2017 Mar 31; 118(13):138101. PMID: 28409990.
      View in: PubMed
    14. Weiss JN, Qu Z, Shivkumar K. Electrophysiology of Hypokalemia and Hyperkalemia. Circ Arrhythm Electrophysiol. 2017 Mar; 10(3). PMID: 28314851.
      View in: PubMed
    15. Chiamvimonvat N, Chen-Izu Y, Clancy CE, Deschenes I, Dobrev D, Heijman J, Izu L, Qu Z, Ripplinger CM, Vandenberg JI, Weiss JN, Koren G, Banyasz T, Grandi E, Sanguinetti MC, Bers DM, Nerbonne JM. Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics. J Physiol. 2017 Apr 01; 595(7):2229-2252. PMID: 27808412.
      View in: PubMed
    16. Liu MB, Ko CY, Song Z, Garfinkel A, Weiss JN, Qu Z. A Dynamical Threshold for Cardiac Delayed Afterdepolarization-Mediated Triggered Activity. Biophys J. 2016 Dec 06; 111(11):2523-2533. PMID: 27926853.
      View in: PubMed
    17. Rau CD, Romay MC, Tuteryan M, Wang JJ, Santolini M, Ren S, Karma A, Weiss JN, Wang Y, Lusis AJ. Systems Genetics Approach Identifies Gene Pathways and Adamts2 as Drivers of Isoproterenol-Induced Cardiac Hypertrophy and Cardiomyopathy in Mice. Cell Syst. 2017 Jan 25; 4(1):121-128.e4. PMID: 27866946.
      View in: PubMed
    18. Savalli N, Pantazis A, Sigg D, Weiss JN, Neely A, Olcese R. The a2d-1 subunit remodels CaV1.2 voltage sensors and allows Ca2+ influx at physiological membrane potentials. J Gen Physiol. 2016 Aug; 148(2):147-59. PMID: 27481713; PMCID: PMC4969795 [Available on 02/01/17].
    19. Ponnaluri AV, Perotti LE, Liu M, Qu Z, Weiss JN, Ennis DB, Klug WS, Garfinkel A. Electrophysiology of Heart Failure Using a Rabbit Model: From the Failing Myocyte to Ventricular Fibrillation. PLoS Comput Biol. 2016 06; 12(6):e1004968. PMID: 27336310.
      View in: PubMed
    20. Karbassi E, Monte E, Chapski DJ, Lopez R, Rosa Garrido M, Kim J, Wisniewski N, Rau CD, Wang JJ, Weiss JN, Wang Y, Lusis AJ, Vondriska TM. Relationship of disease-associated gene expression to cardiac phenotype is buffered by genetic diversity and chromatin regulation. Physiol Genomics. 2016 08 01; 48(8):601-15. PMID: 27287924.
      View in: PubMed
    21. Weiss JN, Qu Z, Shivkumar K. Ablating atrial fibrillation: A translational science perspective for clinicians. Heart Rhythm. 2016 09; 13(9):1868-77. PMID: 27241354.
      View in: PubMed
    22. Korge P, Calmettes G, Weiss JN. Reactive oxygen species production in cardiac mitochondria after complex I inhibition: Modulation by substrate-dependent regulation of the NADH/NAD(+) ratio. Free Radic Biol Med. 2016 07; 96:22-33. PMID: 27068062; PMCID: PMC4912463 [Available on 07/01/17].
    23. Weiss JN. New Roles for an Old Pore. Circ Res. 2016 Mar 04; 118(5):779-80. PMID: 26941420; PMCID: PMC4780247 [Available on 03/04/17].
    24. Prudat Y, Madhvani RV, Angelini M, Borgstom NP, Garfinkel A, Karagueuzian HS, Weiss JN, de Lange E, Olcese R, Kucera JP. Stochastic pacing reveals the propensity to cardiac action potential alternans and uncovers its underlying dynamics. J Physiol. 2016 05 01; 594(9):2537-53. PMID: 26563830; PMCID: PMC4850193 [Available on 04/28/17].
    25. Song Z, Karma A, Weiss JN, Qu Z. Long-Lasting Sparks: Multi-Metastability and Release Competition in the Calcium Release Unit Network. PLoS Comput Biol. 2016 Jan; 12(1):e1004671. PMID: 26730593; PMCID: PMC4701461.
    26. Chan YH, Tsai WC, Ko JS, Yin D, Chang PC, Rubart M, Weiss JN, Everett TH, Lin SF, Chen PS. Small-Conductance Calcium-Activated Potassium Current Is Activated During Hypokalemia and Masks Short-Term Cardiac Memory Induced by Ventricular Pacing. Circulation. 2015 Oct 13; 132(15):1377-86. PMID: 26362634; PMCID: PMC4605871 [Available on 10/13/16].
    27. Pezhouman A, Singh N, Song Z, Nivala M, Eskandari A, Cao H, Bapat A, Ko CY, Nguyen T, Qu Z, Karagueuzian HS, Weiss JN. Molecular Basis of Hypokalemia-Induced Ventricular Fibrillation. Circulation. 2015 Oct 20; 132(16):1528-1537. PMID: 26269574; PMCID: PMC4618042 [Available on 10/20/16].
    28. Ping P, Gustafsson ÅB, Bers DM, Blatter LA, Cai H, Jahangir A, Kelly D, Muoio D, O'Rourke B, Rabinovitch P, Trayanova N, Van Eyk J, Weiss JN, Wong R, Schwartz Longacre L. Harnessing the Power of Integrated Mitochondrial Biology and Physiology: A Special Report on the NHLBI Mitochondria in Heart Diseases Initiative. Circ Res. 2015 Jul 17; 117(3):234-8. PMID: 26185209; PMCID: PMC4535701.
    29. Liu MB, de Lange E, Garfinkel A, Weiss JN, Qu Z. Delayed afterdepolarizations generate both triggers and a vulnerable substrate promoting reentry in cardiac tissue. Heart Rhythm. 2015 Oct; 12(10):2115-24. PMID: 26072025.
      View in: PubMed
    30. Madhvani RV, Angelini M, Xie Y, Pantazis A, Suriany S, Borgstrom NP, Garfinkel A, Qu Z, Weiss JN, Olcese R. Targeting the late component of the cardiac L-type Ca2+ current to suppress early afterdepolarizations. J Gen Physiol. 2015 May; 145(5):395-404. PMID: 25918358; PMCID: PMC4411259.
    31. Song Z, Ko CY, Nivala M, Weiss JN, Qu Z. Calcium-voltage coupling in the genesis of early and delayed afterdepolarizations in cardiac myocytes. Biophys J. 2015 Apr 21; 108(8):1908-21. PMID: 25902431; PMCID: PMC4407256.
    32. Clancy CE, Chen-Izu Y, Bers DM, Belardinelli L, Boyden PA, Csernoch L, Despa S, Fermini B, Hool LC, Izu L, Kass RS, Lederer WJ, Louch WE, Maack C, Matiazzi A, Qu Z, Rajamani S, Rippinger CM, Sejersted OM, O'Rourke B, Weiss JN, Varró A, Zaza A. Deranged sodium to sudden death. J Physiol. 2015 Mar 15; 593(6):1331-45. PMID: 25772289; PMCID: PMC4376414.
    33. Weiss JN. Palpitations, potassium and the pump. J Physiol. 2015 Mar 15; 593(6):1387-8. PMID: 25772294; PMCID: PMC4376419.
    34. Nguyen TP, Singh N, Xie Y, Qu Z, Weiss JN. Repolarization reserve evolves dynamically during the cardiac action potential: effects of transient outward currents on early afterdepolarizations. Circ Arrhythm Electrophysiol. 2015 Jun; 8(3):694-702. PMID: 25772542; PMCID: PMC4472560.
    35. Weiss JN, Garfinkel A, Karagueuzian HS, Nguyen TP, Olcese R, Chen PS, Qu Z. Perspective: a dynamics-based classification of ventricular arrhythmias. J Mol Cell Cardiol. 2015 May; 82:136-52. PMID: 25769672; PMCID: PMC4405495.
    36. Korge P, Calmettes G, Weiss JN. Increased reactive oxygen species production during reductive stress: The roles of mitochondrial glutathione and thioredoxin reductases. Biochim Biophys Acta. 2015 Jun-Jul; 1847(6-7):514-25. PMID: 25701705; PMCID: PMC4426053.
    37. Chan YH, Tsai WC, Song Z, Ko CY, Qu Z, Weiss JN, Lin SF, Chen PS, Jones LR, Chen Z. Acute reversal of phospholamban inhibition facilitates the rhythmic whole-cell propagating calcium waves in isolated ventricular myocytes. J Mol Cell Cardiol. 2015 Mar; 80:126-35. PMID: 25596331; PMCID: PMC4346431.
    38. Krishnamoorthi S, Perotti LE, Borgstrom NP, Ajijola OA, Frid A, Ponnaluri AV, Weiss JN, Qu Z, Klug WS, Ennis DB, Garfinkel A. Simulation Methods and Validation Criteria for Modeling Cardiac Ventricular Electrophysiology. PLoS One. 2014; 9(12):e114494. PMID: 25493967; PMCID: PMC4262432.
    39. Nivala M, Song Z, Weiss JN, Qu Z. T-tubule disruption promotes calcium alternans in failing ventricular myocytes: mechanistic insights from computational modeling. J Mol Cell Cardiol. 2015 Feb; 79:32-41. PMID: 25450613; PMCID: PMC4323351.
    40. Qu Z, Weiss JN. Mechanisms of ventricular arrhythmias: from molecular fluctuations to electrical turbulence. Annu Rev Physiol. 2015; 77:29-55. PMID: 25340965; PMCID: PMC4342983.
    41. Qu Z, Hu G, Garfinkel A, Weiss JN. Nonlinear and Stochastic Dynamics in the Heart. Phys Rep. 2014 Oct 10; 543(2):61-162. PMID: 25267872.
      View in: PubMed
    42. Calmettes G, Ribalet B, John S, Korge P, Ping P, Weiss JN. Hexokinases and cardioprotection. J Mol Cell Cardiol. 2015 Jan; 78:107-15. PMID: 25264175; PMCID: PMC4268312.
    43. Yu CC, Ai T, Weiss JN, Chen PS. Apamin does not inhibit human cardiac Na+ current, L-type Ca2+ current or other major K+ currents. PLoS One. 2014; 9(5):e96691. PMID: 24798465; PMCID: PMC4010514.
    44. Sadoshima J, Weiss JN. Cardiac fibroblasts: the good, the bad, the ugly, the beautiful. J Mol Cell Cardiol. 2014 May; 70:1. PMID: 24650876; PMCID: PMC4826044.
    45. Liem DA, Nsair A, Setty SP, Cadeiras M, Wang D, Maclellan R, Lotz C, Lin AJ, Tabaraki J, Li H, Ge J, Odeberg J, Ponten F, Larson E, Mulder J, Lundberg E, Weiss JN, Uhlen M, Ping P, Deng MC. Molecular- and organelle-based predictive paradigm underlying recovery by left ventricular assist device support. Circ Heart Fail. 2014 Mar 01; 7(2):359-66. PMID: 24643888; PMCID: PMC4397259.
    46. Calmettes G, Weiss JN. A quantitative method to track protein translocation between intracellular compartments in real-time in live cells using weighted local variance image analysis. PLoS One. 2013; 8(12):e81988. PMID: 24376509; PMCID: PMC3869670.
    47. Lotz C, Lin AJ, Black CM, Zhang J, Lau E, Deng N, Wang Y, Zong NC, Choi JH, Xu T, Liem DA, Korge P, Weiss JN, Hermjakob H, Yates JR, Apweiler R, Ping P. Characterization, design, and function of the mitochondrial proteome: from organs to organisms. J Proteome Res. 2014 Feb 07; 13(2):433-46. PMID: 24070373; PMCID: PMC4076470.
    48. Nguyen TP, Qu Z, Weiss JN. Cardiac fibrosis and arrhythmogenesis: the road to repair is paved with perils. J Mol Cell Cardiol. 2014 May; 70:83-91. PMID: 24184999; PMCID: PMC3995831.
    49. Calmettes G, John SA, Weiss JN, Ribalet B. Hexokinase-mitochondrial interactions regulate glucose metabolism differentially in adult and neonatal cardiac myocytes. J Gen Physiol. 2013 Oct; 142(4):425-36. PMID: 24081983; PMCID: PMC3787771.
    50. Nivala M, Ko CY, Nivala M, Weiss JN, Qu Z. The emergence of subcellular pacemaker sites for calcium waves and oscillations. J Physiol. 2013 Nov 01; 591(21):5305-20. PMID: 24042497; PMCID: PMC3936369.
    51. Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, Deng N, Kim AK, Choi JH, Zelaya I, Liem D, Meyer D, Odeberg J, Fang C, Lu HJ, Xu T, Weiss J, Duan H, Uhlen M, Yates JR, Apweiler R, Ge J, Hermjakob H, Ping P. Integration of cardiac proteome biology and medicine by a specialized knowledgebase. Circ Res. 2013 Oct 12; 113(9):1043-53. PMID: 23965338; PMCID: PMC4076475.
    52. Chang PC, Hsieh YC, Hsueh CH, Weiss JN, Lin SF, Chen PS. Apamin induces early afterdepolarizations and torsades de pointes ventricular arrhythmia from failing rabbit ventricles exhibiting secondary rises in intracellular calcium. Heart Rhythm. 2013 Oct; 10(10):1516-24. PMID: 23835258; PMCID: PMC3832504.
    53. Lee YS, Chang PC, Hsueh CH, Maruyama M, Park HW, Rhee KS, Hsieh YC, Shen C, Weiss JN, Chen Z, Lin SF, Chen PS. Apamin-sensitive calcium-activated potassium currents in rabbit ventricles with chronic myocardial infarction. J Cardiovasc Electrophysiol. 2013 Oct; 24(10):1144-53. PMID: 23718850; PMCID: PMC4207647.
    54. Youn JY, Zhang J, Zhang Y, Chen H, Liu D, Ping P, Weiss JN, Cai H. Oxidative stress in atrial fibrillation: an emerging role of NADPH oxidase. J Mol Cell Cardiol. 2013 Sep; 62:72-9. PMID: 23643589; PMCID: PMC3735724.
    55. Qu Z, Xie LH, Olcese R, Karagueuzian HS, Chen PS, Garfinkel A, Weiss JN. Early afterdepolarizations in cardiac myocytes: beyond reduced repolarization reserve. Cardiovasc Res. 2013 Jul 01; 99(1):6-15. PMID: 23619423; PMCID: PMC3687754.
    56. Rau CD, Wisniewski N, Orozco LD, Bennett B, Weiss J, Lusis AJ. Maximal information component analysis: a novel non-linear network analysis method. Front Genet. 2013; 4:28. PMID: 23487572; PMCID: PMC3594742.
    57. Hsieh YC, Chang PC, Hsueh CH, Lee YS, Shen C, Weiss JN, Chen Z, Ai T, Lin SF, Chen PS. Apamin-sensitive potassium current modulates action potential duration restitution and arrhythmogenesis of failing rabbit ventricles. Circ Arrhythm Electrophysiol. 2013 Apr; 6(2):410-8. PMID: 23420832; PMCID: PMC3678988.
    58. Karagueuzian HS, Nguyen TP, Qu Z, Weiss JN. Oxidative stress, fibrosis, and early afterdepolarization-mediated cardiac arrhythmias. Front Physiol. 2013; 4:19. PMID: 23423152; PMCID: PMC3573324.
    59. Chang MG, de Lange E, Calmettes G, Garfinkel A, Qu Z, Weiss JN. Pro- and antiarrhythmic effects of ATP-sensitive potassium current activation on reentry during early afterdepolarization-mediated arrhythmias. Heart Rhythm. 2013 Apr; 10(4):575-82. PMID: 23246594.
      View in: PubMed
    60. Qu Z, Nivala M, Weiss JN. Calcium alternans in cardiac myocytes: order from disorder. J Mol Cell Cardiol. 2013 May; 58:100-9. PMID: 23104004.
      View in: PubMed
    61. Xi Y, Ai T, De Lange E, Li Z, Wu G, Brunelli L, Kyle WB, Turker I, Cheng J, Ackerman MJ, Kimura A, Weiss JN, Qu Z, Kim JJ, Faulkner G, Vatta M. Loss of function of hNav1.5 by a ZASP1 mutation associated with intraventricular conduction disturbances in left ventricular noncompaction. Circ Arrhythm Electrophysiol. 2012 Oct; 5(5):1017-26. PMID: 22929165; PMCID: PMC4331025.
    62. Ghazalpour A, Rau CD, Farber CR, Bennett BJ, Orozco LD, van Nas A, Pan C, Allayee H, Beaven SW, Civelek M, Davis RC, Drake TA, Friedman RA, Furlotte N, Hui ST, Jentsch JD, Kostem E, Kang HM, Kang EY, Joo JW, Korshunov VA, Laughlin RE, Martin LJ, Ohmen JD, Parks BW, Pellegrini M, Reue K, Smith DJ, Tetradis S, Wang J, Wang Y, Weiss JN, Kirchgessner T, Gargalovic PS, Eskin E, Lusis AJ, LeBoeuf RC. Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits. Mamm Genome. 2012 Oct; 23(9-10):680-92. PMID: 22892838; PMCID: PMC3586763.
    63. Weiss JN, Karma A, MacLellan WR, Deng M, Rau CD, Rees CM, Wang J, Wisniewski N, Eskin E, Horvath S, Qu Z, Wang Y, Lusis AJ. "Good enough solutions" and the genetics of complex diseases. Circ Res. 2012 Aug 03; 111(4):493-504. PMID: 22859671; PMCID: PMC3428228.
    64. Chang MG, Chang CY, de Lange E, Xu L, O'Rourke B, Karagueuzian HS, Tung L, Marbán E, Garfinkel A, Weiss JN, Qu Z, Abraham MR. Dynamics of early afterdepolarization-mediated triggered activity in cardiac monolayers. Biophys J. 2012 Jun 20; 102(12):2706-14. PMID: 22735520; PMCID: PMC3379011.
    65. Nivala M, Ko CY, Nivala M, Weiss JN, Qu Z. Criticality in intracellular calcium signaling in cardiac myocytes. Biophys J. 2012 Jun 06; 102(11):2433-42. PMID: 22713558; PMCID: PMC3368125.
    66. Zhang J, Lin A, Powers J, Lam MP, Lotz C, Liem D, Lau E, Wang D, Deng N, Korge P, Zong NC, Cai H, Weiss J, Ping P. Perspectives on: SGP symposium on mitochondrial physiology and medicine: mitochondrial proteome design: from molecular identity to pathophysiological regulation. J Gen Physiol. 2012 Jun; 139(6):395-406. PMID: 22641634; PMCID: PMC3362520.
    67. Bapat A, Nguyen TP, Lee JH, Sovari AA, Fishbein MC, Weiss JN, Karagueuzian HS. Enhanced sensitivity of aged fibrotic hearts to angiotensin II- and hypokalemia-induced early afterdepolarization-mediated ventricular arrhythmias. Am J Physiol Heart Circ Physiol. 2012 Jun 01; 302(11):H2331-40. PMID: 22467308; PMCID: PMC3378307.
    68. Nguyen TP, Xie Y, Garfinkel A, Qu Z, Weiss JN. Arrhythmogenic consequences of myofibroblast-myocyte coupling. Cardiovasc Res. 2012 Feb 01; 93(2):242-51. PMID: 22049532; PMCID: PMC3258652.
    69. Nivala M, Korge P, Nivala M, Weiss JN, Qu Z. Linking flickering to waves and whole-cell oscillations in a mitochondrial network model. Biophys J. 2011 Nov 02; 101(9):2102-11. PMID: 22067147; PMCID: PMC3207179.
    70. Calaghan S, Steele D, Weiss JN. Local signalling in myocytes. J Mol Cell Cardiol. 2012 Feb; 52(2):295-7. PMID: 22064326.
      View in: PubMed
    71. Numata A, Miyauchi Y, Ono N, Fishbein MC, Mandel WJ, Lin SF, Weiss JN, Chen PS, Karagueuzian HS. Spontaneous atrial fibrillation initiated by tyramine in canine atria with increased sympathetic nerve sprouting. J Cardiovasc Electrophysiol. 2012 Apr; 23(4):415-22. PMID: 22034958; PMCID: PMC4364657.
    72. Madhvani RV, Xie Y, Pantazis A, Garfinkel A, Qu Z, Weiss JN, Olcese R. Shaping a new Ca²? conductance to suppress early afterdepolarizations in cardiac myocytes. J Physiol. 2011 Dec 15; 589(Pt 24):6081-92. PMID: 22025660; PMCID: PMC3286687.
    73. Korge P, Yang L, Yang JH, Wang Y, Qu Z, Weiss JN. Protective role of transient pore openings in calcium handling by cardiac mitochondria. J Biol Chem. 2011 Oct 07; 286(40):34851-7. PMID: 21859717; PMCID: PMC3186421.
    74. Chang MG, Sato D, de Lange E, Lee JH, Karagueuzian HS, Garfinkel A, Weiss JN, Qu Z. Bi-stable wave propagation and early afterdepolarization-mediated cardiac arrhythmias. Heart Rhythm. 2012 Jan; 9(1):115-22. PMID: 21855520; PMCID: PMC3246094.
    75. Sdek P, Zhao P, Wang Y, Huang CJ, Ko CY, Butler PC, Weiss JN, Maclellan WR. Rb and p130 control cell cycle gene silencing to maintain the postmitotic phenotype in cardiac myocytes. J Cell Biol. 2011 Aug 08; 194(3):407-23. PMID: 21825075; PMCID: PMC3153646.
    76. Qu Z, Garfinkel A, Weiss JN, Nivala M. Multi-scale modeling in biology: how to bridge the gaps between scales? Prog Biophys Mol Biol. 2011 Oct; 107(1):21-31. PMID: 21704063; PMCID: PMC3190585.
    77. Morita N, Lee JH, Bapat A, Fishbein MC, Mandel WJ, Chen PS, Weiss JN, Karagueuzian HS. Glycolytic inhibition causes spontaneous ventricular fibrillation in aged hearts. Am J Physiol Heart Circ Physiol. 2011 Jul; 301(1):H180-91. PMID: 21478408; PMCID: PMC3302192.
    78. John S, Weiss JN, Ribalet B. Subcellular localization of hexokinases I and II directs the metabolic fate of glucose. PLoS One. 2011 Mar 09; 6(3):e17674. PMID: 21408025; PMCID: PMC3052386.
    79. Chua SK, Chang PC, Maruyama M, Turker I, Shinohara T, Shen MJ, Chen Z, Shen C, Rubart-von der Lohe M, Lopshire JC, Ogawa M, Weiss JN, Lin SF, Ai T, Chen PS. Small-conductance calcium-activated potassium channel and recurrent ventricular fibrillation in failing rabbit ventricles. Circ Res. 2011 Apr 15; 108(8):971-9. PMID: 21350217; PMCID: PMC3086382.
    80. Joung B, Park HW, Maruyama M, Tang L, Song J, Han S, Piccirillo G, Weiss JN, Lin SF, Chen PS. Intracellular calcium and the mechanism of anodal supernormal excitability in langendorff perfused rabbit ventricles. Circ J. 2011; 75(4):834-43. PMID: 21301131; PMCID: PMC3366464.
    81. Morita N, Lee JH, Xie Y, Sovari A, Qu Z, Weiss JN, Karagueuzian HS. Suppression of re-entrant and multifocal ventricular fibrillation by the late sodium current blocker ranolazine. J Am Coll Cardiol. 2011 Jan 18; 57(3):366-75. PMID: 21232675; PMCID: PMC4344130.
    82. Weiss JN, Nivala M, Garfinkel A, Qu Z. Alternans and arrhythmias: from cell to heart. Circ Res. 2011 Jan 07; 108(1):98-112. PMID: 21212392; PMCID: PMC3076605.
    83. John SA, Ribalet B, Weiss JN, Philipson KD, Ottolia M. Ca2+-dependent structural rearrangements within Na+-Ca2+ exchanger dimers. Proc Natl Acad Sci U S A. 2011 Jan 25; 108(4):1699-704. PMID: 21209335; PMCID: PMC3029690.
    84. Baher AA, Uy M, Xie F, Garfinkel A, Qu Z, Weiss JN. Bidirectional ventricular tachycardia: ping pong in the His-Purkinje system. Heart Rhythm. 2011 Apr; 8(4):599-605. PMID: 21118730; PMCID: PMC3066157.
    85. Qu Z, Xie Y, Garfinkel A, Weiss JN. T-wave alternans and arrhythmogenesis in cardiac diseases. Front Physiol. 2010; 1:154. PMID: 21286254; PMCID: PMC3028203.
    86. Maruyama M, Lin SF, Xie Y, Chua SK, Joung B, Han S, Shinohara T, Shen MJ, Qu Z, Weiss JN, Chen PS. Genesis of phase 3 early afterdepolarizations and triggered activity in acquired long-QT syndrome. Circ Arrhythm Electrophysiol. 2011 Feb; 4(1):103-11. PMID: 21078812; PMCID: PMC3045276.
    87. de Diego C, Chen F, Xie Y, Pai RK, Slavin L, Parker J, Lamp ST, Qu Z, Weiss JN, Valderrábano M. Anisotropic conduction block and reentry in neonatal rat ventricular myocyte monolayers. Am J Physiol Heart Circ Physiol. 2011 Jan; 300(1):H271-8. PMID: 21037233; PMCID: PMC3023258.
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    89. Xie Y, Sato D, Garfinkel A, Qu Z, Weiss JN. So little source, so much sink: requirements for afterdepolarizations to propagate in tissue. Biophys J. 2010 Sep 08; 99(5):1408-15. PMID: 20816052; PMCID: PMC2931729.
    90. Sato D, Xie LH, Nguyen TP, Weiss JN, Qu Z. Irregularly appearing early afterdepolarizations in cardiac myocytes: random fluctuations or dynamical chaos? Biophys J. 2010 Aug 04; 99(3):765-73. PMID: 20682253; PMCID: PMC2913181.
    91. Chen F, De Diego C, Chang MG, McHarg JL, John S, Klitzner TS, Weiss JN. Atrioventricular conduction and arrhythmias at the initiation of beating in embryonic mouse hearts. Dev Dyn. 2010 Jul; 239(7):1941-9. PMID: 20549739; PMCID: PMC2908293.
    92. Deng N, Zhang J, Zong C, Wang Y, Lu H, Yang P, Wang W, Young GW, Wang Y, Korge P, Lotz C, Doran P, Liem DA, Apweiler R, Weiss JN, Duan H, Ping P. Phosphoproteome analysis reveals regulatory sites in major pathways of cardiac mitochondria. Mol Cell Proteomics. 2011 Feb; 10(2):M110.000117. PMID: 20495213; PMCID: PMC3033665.
    93. Yang L, Korge P, Weiss JN, Qu Z. Mitochondrial oscillations and waves in cardiac myocytes: insights from computational models. Biophys J. 2010 Apr 21; 98(8):1428-38. PMID: 20409461; PMCID: PMC2856135.
    94. Rovetti R, Cui X, Garfinkel A, Weiss JN, Qu Z. Spark-induced sparks as a mechanism of intracellular calcium alternans in cardiac myocytes. Circ Res. 2010 May 28; 106(10):1582-91. PMID: 20378857; PMCID: PMC2893409.
    95. Weiss JN, Yang JH. Oscillations at odds in the heart. J Gen Physiol. 2010 Apr; 135(4):303-5. PMID: 20231371; PMCID: PMC2847923.
    96. Ji S, Gupta N, Weiss JN. The heart and its nerves: a nervous bond. Heart Rhythm. 2010 Apr; 7(4):504-5. PMID: 20189496.
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    98. Maruyama M, Joung B, Tang L, Shinohara T, On YK, Han S, Choi EK, Kim DH, Shen MJ, Weiss JN, Lin SF, Chen PS. Diastolic intracellular calcium-membrane voltage coupling gain and postshock arrhythmias: role of purkinje fibers and triggered activity. Circ Res. 2010 Feb 05; 106(2):399-408. PMID: 19926871; PMCID: PMC2818796.
    99. Morita N, Sovari AA, Xie Y, Fishbein MC, Mandel WJ, Garfinkel A, Lin SF, Chen PS, Xie LH, Chen F, Qu Z, Weiss JN, Karagueuzian HS. Increased susceptibility of aged hearts to ventricular fibrillation during oxidative stress. Am J Physiol Heart Circ Physiol. 2009 Nov; 297(5):H1594-605. PMID: 19767530; PMCID: PMC2781379.
    100. Xie Y, Garfinkel A, Camelliti P, Kohl P, Weiss JN, Qu Z. Effects of fibroblast-myocyte coupling on cardiac conduction and vulnerability to reentry: A computational study. Heart Rhythm. 2009 Nov; 6(11):1641-9. PMID: 19879544; PMCID: PMC3013501.
    101. Sato D, Xie Y, Weiss JN, Qu Z, Garfinkel A, Sanderson AR. Acceleration of cardiac tissue simulation with graphic processing units. Med Biol Eng Comput. 2009 Sep; 47(9):1011-5. PMID: 19655187; PMCID: PMC2734265.
    102. Cui X, Rovetti RJ, Yang L, Garfinkel A, Weiss JN, Qu Z. Period-doubling bifurcation in an array of coupled stochastically excitable elements subjected to global periodic forcing. Phys Rev Lett. 2009 Jul 24; 103(4):044102. PMID: 19659359; PMCID: PMC2761886.
    103. Xie LH, Weiss JN. Arrhythmogenic consequences of intracellular calcium waves. Am J Physiol Heart Circ Physiol. 2009 Sep; 297(3):H997-H1002. PMID: 19561309; PMCID: PMC2755983.
    104. Tran DX, Sato D, Yochelis A, Weiss JN, Garfinkel A, Qu Z. Bifurcation and chaos in a model of cardiac early afterdepolarizations. Phys Rev Lett. 2009 Jun 26; 102(25):258103. PMID: 19659123; PMCID: PMC2726623.
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    106. Sato D, Xie LH, Sovari AA, Tran DX, Morita N, Xie F, Karagueuzian H, Garfinkel A, Weiss JN, Qu Z. Synchronization of chaotic early afterdepolarizations in the genesis of cardiac arrhythmias. Proc Natl Acad Sci U S A. 2009 Mar 03; 106(9):2983-8. PMID: 19218447; PMCID: PMC2651322.
    107. Ogawa M, Morita N, Tang L, Karagueuzian HS, Weiss JN, Lin SF, Chen PS. Mechanisms of recurrent ventricular fibrillation in a rabbit model of pacing-induced heart failure. Heart Rhythm. 2009 Jun; 6(6):784-92. PMID: 19467505; PMCID: PMC2752449.
    108. Joung B, Tang L, Maruyama M, Han S, Chen Z, Stucky M, Jones LR, Fishbein MC, Weiss JN, Chen PS, Lin SF. Intracellular calcium dynamics and acceleration of sinus rhythm by beta-adrenergic stimulation. Circulation. 2009 Feb 17; 119(6):788-96. PMID: 19188501; PMCID: PMC2735196.
    109. Lu G, Sun H, Korge P, Koehler CM, Weiss JN, Wang Y. Functional characterization of a mitochondrial Ser/Thr protein phosphatase in cell death regulation. Methods Enzymol. 2009; 457:255-73. PMID: 19426872; PMCID: PMC3705213.
    110. Xie LH, Chen F, Karagueuzian HS, Weiss JN. Oxidative-stress-induced afterdepolarizations and calmodulin kinase II signaling. Circ Res. 2009 Jan 02; 104(1):79-86. PMID: 19038865; PMCID: PMC2747806.
    111. de Diego C, Pai RK, Chen F, Xie LH, De Leeuw J, Weiss JN, Valderrábano M. Electrophysiological consequences of acute regional ischemia/reperfusion in neonatal rat ventricular myocyte monolayers. Circulation. 2008 Dec 02; 118(23):2330-7. PMID: 19015404; PMCID: PMC2730415.
    112. Yang JH, Yang L, Qu Z, Weiss JN. Glycolytic oscillations in isolated rabbit ventricular myocytes. J Biol Chem. 2008 Dec 26; 283(52):36321-7. PMID: 18948270; PMCID: PMC2606010.
    113. Huffaker RB, Samade R, Weiss JN, Kogan B. Tachycardia-induced early afterdepolarizations: insights into potential ionic mechanisms from computer simulations. Comput Biol Med. 2008 Nov-Dec; 38(11-12):1140-51. PMID: 18849025; PMCID: PMC3089801.
    114. Rudy Y, Ackerman MJ, Bers DM, Clancy CE, Houser SR, London B, McCulloch AD, Przywara DA, Rasmusson RL, Solaro RJ, Trayanova NA, Van Wagoner DR, Varró A, Weiss JN, Lathrop DA. Systems approach to understanding electromechanical activity in the human heart: a national heart, lung, and blood institute workshop summary. Circulation. 2008 Sep 09; 118(11):1202-11. PMID: 18779456; PMCID: PMC2908516.
    115. Korge P, Ping P, Weiss JN. Reactive oxygen species production in energized cardiac mitochondria during hypoxia/reoxygenation: modulation by nitric oxide. Circ Res. 2008 Oct 10; 103(8):873-80. PMID: 18776040; PMCID: PMC2755534.
    116. Hwang GS, Tang L, Joung B, Morita N, Hayashi H, Karagueuzian HS, Weiss JN, Lin SF, Chen PS. Superiority of biphasic over monophasic defibrillation shocks is attributable to less intracellular calcium transient heterogeneity. J Am Coll Cardiol. 2008 Sep 02; 52(10):828-35. PMID: 18755345; PMCID: PMC2573049.
    117. Restrepo JG, Weiss JN, Karma A. Calsequestrin-mediated mechanism for cellular calcium transient alternans. Biophys J. 2008 Oct; 95(8):3767-89. PMID: 18676655.
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    119. Yang L, Vondriska TM, Han Z, Maclellan WR, Weiss JN, Qu Z. Deducing topology of protein-protein interaction networks from experimentally measured sub-networks. BMC Bioinformatics. 2008 Jul 03; 9:301. PMID: 18598366; PMCID: PMC2474618.
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    121. Maclellan WR, Wang Y, Vondriska TM, Weiss JN, Ping P. Proteomic insights into cardiac cell death and survival. Proteomics Clin Appl. 2008 Jun; 2(6):837-44. PMID: 21136883; PMCID: PMC3808833.
    122. Zhang J, Liem DA, Mueller M, Wang Y, Zong C, Deng N, Vondriska TM, Korge P, Drews O, Maclellan WR, Honda H, Weiss JN, Apweiler R, Ping P. Altered proteome biology of cardiac mitochondria under stress conditions. J Proteome Res. 2008 Jun; 7(6):2204-14. PMID: 18484766; PMCID: PMC3805274.
    123. Sovari AA, Morita N, Weiss JN, Karagueuzian HS. Serum transforming growth factor-beta1 as a risk stratifier of sudden cardiac death. Med Hypotheses. 2008 Aug; 71(2):262-5. PMID: 18448260; PMCID: PMC3063398.
    124. Zhang J, Li X, Mueller M, Wang Y, Zong C, Deng N, Vondriska TM, Liem DA, Yang JI, Korge P, Honda H, Weiss JN, Apweiler R, Ping P. Systematic characterization of the murine mitochondrial proteome using functionally validated cardiac mitochondria. Proteomics. 2008 Apr; 8(8):1564-75. PMID: 18348319; PMCID: PMC2799225.
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    126. Xie LH, John SA, Ribalet B, Weiss JN. Phosphatidylinositol-4,5-bisphosphate (PIP2) regulation of strong inward rectifier Kir2.1 channels: multilevel positive cooperativity. J Physiol. 2008 Apr 01; 586(7):1833-48. PMID: 18276733; PMCID: PMC2375719.
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    131. John SA, Ottolia M, Weiss JN, Ribalet B. Dynamic modulation of intracellular glucose imaged in single cells using a FRET-based glucose nanosensor. Pflugers Arch. 2008 May; 456(2):307-22. PMID: 18071748; PMCID: PMC4339035.
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    135. Hayashi H, Kamanu SD, Ono N, Kawase A, Chou CC, Weiss JN, Karagueuzian HS, Lin SF, Chen PS. Calcium transient dynamics and the mechanisms of ventricular vulnerability to single premature electrical stimulation in Langendorff-perfused rabbit ventricles. Heart Rhythm. 2008 Jan; 5(1):116-23. PMID: 18180025; PMCID: PMC2756777.
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    139. Gudzenko V, Shiferaw Y, Savalli N, Vyas R, Weiss JN, Olcese R. Influence of channel subunit composition on L-type Ca2+ current kinetics and cardiac wave stability. Am J Physiol Heart Circ Physiol. 2007 Sep; 293(3):H1805-15. PMID: 17545475.
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    144. Chou CC, Zhou S, Hayashi H, Nihei M, Liu YB, Wen MS, Yeh SJ, Fishbein MC, Weiss JN, Lin SF, Wu D, Chen PS. Remodelling of action potential and intracellular calcium cycling dynamics during subacute myocardial infarction promotes ventricular arrhythmias in Langendorff-perfused rabbit hearts. J Physiol. 2007 May 01; 580(Pt.3):895-906. PMID: 17272354; PMCID: PMC2075460.
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    151. Weiss JN, Yang L, Qu Z. Systems biology approaches to metabolic and cardiovascular disorders: network perspectives of cardiovascular metabolism. J Lipid Res. 2006 Nov; 47(11):2355-66. PMID: 16946414.
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    152. Ono N, Hayashi H, Kawase A, Lin SF, Li H, Weiss JN, Chen PS, Karagueuzian HS. Spontaneous atrial fibrillation initiated by triggered activity near the pulmonary veins in aged rats subjected to glycolytic inhibition. Am J Physiol Heart Circ Physiol. 2007 Jan; 292(1):H639-48. PMID: 16920811.
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    156. Qu Z, Weiss JN. Dynamics and cardiac arrhythmias. J Cardiovasc Electrophysiol. 2006 Sep; 17(9):1042-9. PMID: 16899089.
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    157. Valderrábano M, Chen F, Dave AS, Lamp ST, Klitzner TS, Weiss JN. Atrioventricular ring reentry in embryonic mouse hearts. Circulation. 2006 Aug 08; 114(6):543-9. PMID: 16880324.
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    158. Xie LH, John SA, Ribalet B, Weiss JN. Activation of inwardly rectifying potassium (Kir) channels by phosphatidylinosital-4,5-bisphosphate (PIP2): interaction with other regulatory ligands. Prog Biophys Mol Biol. 2007 Jul; 94(3):320-35. PMID: 16837026.
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    164. Yang L, Han Z, Robb MacLellan W, Weiss JN, Qu Z. Linking cell division to cell growth in a spatiotemporal model of the cell cycle. J Theor Biol. 2006 Jul 07; 241(1):120-33. PMID: 16387327; PMCID: PMC2750880.
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    170. Chen PS, Weiss JN. Runaway pacemakers in ventricular fibrillation. Circulation. 2005 Jul 12; 112(2):148-50. PMID: 16009805.
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    173. Honda HM, Korge P, Weiss JN. Mitochondria and ischemia/reperfusion injury. Ann N Y Acad Sci. 2005 Jun; 1047:248-58. PMID: 16093501.
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    174. Korge P, Honda HM, Weiss JN. K+-dependent regulation of matrix volume improves mitochondrial function under conditions mimicking ischemia-reperfusion. Am J Physiol Heart Circ Physiol. 2005 Jul; 289(1):H66-77. PMID: 15764674.
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    176. Goldhaber JI, Xie LH, Duong T, Motter C, Khuu K, Weiss JN. Action potential duration restitution and alternans in rabbit ventricular myocytes: the key role of intracellular calcium cycling. Circ Res. 2005 Mar 04; 96(4):459-66. PMID: 15662034.
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    177. Han Z, Yang L, MacLellan WR, Weiss JN, Qu Z. Hysteresis and cell cycle transitions: how crucial is it? Biophys J. 2005 Mar; 88(3):1626-34. PMID: 15626707; PMCID: PMC1305219.
    178. Liu YB, Pak HN, Lamp ST, Okuyama Y, Hayashi H, Wu TJ, Weiss JN, Chen PS, Lin SF. Coexistence of two types of ventricular fibrillation during acute regional ischemia in rabbit ventricle. J Cardiovasc Electrophysiol. 2004 Dec; 15(12):1433-40. PMID: 15610292.
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    179. Wang G, Liem DA, Vondriska TM, Honda HM, Korge P, Pantaleon DM, Qiao X, Wang Y, Weiss JN, Ping P. Nitric oxide donors protect murine myocardium against infarction via modulation of mitochondrial permeability transition. Am J Physiol Heart Circ Physiol. 2005 Mar; 288(3):H1290-5. PMID: 15528225.
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    180. Wu TJ, Lin SF, Baher A, Qu Z, Garfinkel A, Weiss JN, Ting CT, Chen PS. Mother rotors and the mechanisms of D600-induced type 2 ventricular fibrillation. Circulation. 2004 Oct 12; 110(15):2110-8. PMID: 15466637.
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