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Deng Jane

Title(s)Associate Professor, Pulmonary and Critical Care Medicine
Phone(310) 825-0617
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    Other Positions
    Title(s)Associate Professor, Medicine


    Collapse Research 
    Collapse Research Activities and Funding
    Neutrophil heterogeneity and function in host defense during pulmonary infection
    VA I01BX004565Jul 1, 2019 - Jun 30, 2023
    Role: Principal Investigator
    Mechanisms of Impaired Neutrophil Responses in PostInfluenza Bacterial Pneumonia
    NIH/NHLBI R01HL108949Jul 13, 2012 - Jun 30, 2017
    Role: Principal Investigator
    Mechanisms of dysregulated immunity with aging
    NIH/NIA R01AG028082Apr 1, 2006 - Mar 31, 2024
    Role: Co-Principal Investigator
    Role of IRAK-M in sepsis-induced immunosuppression
    NIH/NHLBI K08HL081229Sep 15, 2005 - Jul 31, 2012
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Kulkarni U, Zemans RL, Smith CA, Wood SC, Deng JC, Goldstein DR. Excessive neutrophil levels in the lung underlie the age-associated increase in influenza mortality. Mucosal Immunol. 2019 03; 12(2):545-554. PMID: 30617300.
      View in: PubMed
    2. Gurczynski SJ, Nathani N, Warheit-Niemi HI, Hult EM, Podsiad A, Deng J, Zemans RL, Bhan U, Moore BB. CCR2 mediates increased susceptibility to post-H1N1 bacterial pneumonia by limiting dendritic cell induction of IL-17. Mucosal Immunol. 2019 03; 12(2):518-530. PMID: 30498200.
      View in: PubMed
    3. Hensley MK, Deng JC. Acute on Chronic Liver Failure and Immune Dysfunction: A Mimic of Sepsis. Semin Respir Crit Care Med. 2018 Oct; 39(5):588-597. PMID: 30485889.
      View in: PubMed
    4. Hanada S, Pirzadeh M, Carver KY, Deng JC. Respiratory Viral Infection-Induced Microbiome Alterations and Secondary Bacterial Pneumonia. Front Immunol. 2018; 9:2640. PMID: 30505304.
      View in: PubMed
    5. Wang L, Liu SY, Chen HW, Xu J, Chapon M, Zhang T, Zhou F, Wang YE, Quanquin N, Wang G, Tian X, He Z, Liu L, Yu W, Sanchez DJ, Liang Y, Jiang T, Modlin R, Bloom BR, Li Q, Deng JC, Zhou P, Qin FX, Cheng G. Generation of a Live Attenuated Influenza Vaccine that Elicits Broad Protection in Mice and Ferrets. Cell Host Microbe. 2017 Mar 08; 21(3):334-343. PMID: 28279345.
      View in: PubMed
    6. Prasso JE, Deng JC. Postviral Complications: Bacterial Pneumonia. Clin Chest Med. 2017 Mar; 38(1):127-138. PMID: 28159155.
      View in: PubMed
    7. Kamata H, Yamamoto K, Wasserman GA, Zabinski MC, Yuen CK, Lung WY, Gower AC, Belkina AC, Ramirez MI, Deng JC, Quinton LJ, Jones MR, Mizgerd JP. Epithelial Cell-Derived Secreted and Transmembrane 1a Signals to Activated Neutrophils during Pneumococcal Pneumonia. Am J Respir Cell Mol Biol. 2016 09; 55(3):407-18. PMID: 27064756.
      View in: PubMed
    8. Hu SB, Wong DJ, Correa A, Li N, Deng JC. Prediction of Clinical Deterioration in Hospitalized Adult Patients with Hematologic Malignancies Using a Neural Network Model. PLoS One. 2016; 11(8):e0161401. PMID: 27532679; PMCID: PMC4988721.
    9. Zider AD, Zopey R, Garg R, Wang X, Wang TS, Deng JC. Prognostic significance of infections in critically ill adult patients with acute liver injury: a retrospective cohort study. Liver Int. 2016 08; 36(8):1143-50. PMID: 26801954.
      View in: PubMed
    10. Tarabichi Y, Li K, Hu S, Nguyen C, Wang X, Elashoff D, Saira K, Frank B, Bihan M, Ghedin E, Methé BA, Deng JC. The administration of intranasal live attenuated influenza vaccine induces changes in the nasal microbiota and nasal epithelium gene expression profiles. Microbiome. 2015 Dec 15; 3:74. PMID: 26667497.
      View in: PubMed
    11. Mayo MC, Deng JC, Albores J, Zeidler M, Harper RM, Avidan AY. Hypocretin Deficiency Associated with Narcolepsy Type 1 and Central Hypoventilation Syndrome in Neurosarcoidosis of the Hypothalamus. J Clin Sleep Med. 2015 Sep 15; 11(9):1063-5. PMID: 25979096; PMCID: PMC4543251.
    12. Rodriguez R, Jung CL, Gabayan V, Deng JC, Ganz T, Nemeth E, Bulut Y. Hepcidin induction by pathogens and pathogen-derived molecules is strongly dependent on interleukin-6. Infect Immun. 2014 Feb; 82(2):745-52. PMID: 24478088.
      View in: PubMed
    13. Deng JC. Viral-bacterial interactions-therapeutic implications. Influenza Other Respir Viruses. 2013 Nov; 7 Suppl 3:24-35. PMID: 24215379; PMCID: PMC3831167.
    14. Wilson EB, Yamada DH, Elsaesser H, Herskovitz J, Deng J, Cheng G, Aronow BJ, Karp CL, Brooks DG. Blockade of chronic type I interferon signaling to control persistent LCMV infection. Science. 2013 Apr 12; 340(6129):202-7. PMID: 23580528; PMCID: PMC3704950.
    15. Wang T, Derhovanessian A, De Cruz S, Belperio JA, Deng JC, Hoo GS. Subsequent infections in survivors of sepsis: epidemiology and outcomes. J Intensive Care Med. 2014 Mar-Apr; 29(2):87-95. PMID: 23753224; PMCID: PMC4393330.
    16. Tian X, Xu F, Lung WY, Meyerson C, Ghaffari AA, Cheng G, Deng JC. Poly I:C enhances susceptibility to secondary pulmonary infections by gram-positive bacteria. PLoS One. 2012; 7(9):e41879. PMID: 22962579; PMCID: PMC3433467.
    17. Hu SB, Zider A, Deng JC. When host defense goes awry: Modeling sepsis-induced immunosuppression. Drug Discov Today Dis Models. 2012; 9(1):e33-e38. PMID: 24052802.
      View in: PubMed
    18. Weigt SS, Gregson AL, Deng JC, Lynch JP, Belperio JA. Respiratory viral infections in hematopoietic stem cell and solid organ transplant recipients. Semin Respir Crit Care Med. 2011 Aug; 32(4):471-93. PMID: 21858751; PMCID: PMC4209842.
    19. Ghaffari AA, Chow EK, Iyer SS, Deng JC, Cheng G. Polyinosinic-polycytidylic acid suppresses acetaminophen-induced hepatotoxicity independent of type I interferons and toll-like receptor 3. Hepatology. 2011 Jun; 53(6):2042-52. PMID: 21433044; PMCID: PMC3103596.
    20. Palchevskiy V, Hashemi N, Weigt SS, Xue YY, Derhovanessian A, Keane MP, Strieter RM, Fishbein MC, Deng JC, Lynch JP, Elashoff R, Belperio JA. Immune response CC chemokines CCL2 and CCL5 are associated with pulmonary sarcoidosis. Fibrogenesis Tissue Repair. 2011 Apr 04; 4:10. PMID: 21463523; PMCID: PMC3080805.
    21. Deng JC, Standiford TJ. Growth factors and cytokines in acute lung injury. Compr Physiol. 2011 Jan; 1(1):81-104. PMID: 23737165.
      View in: PubMed
    22. Shahangian A, Chow EK, Tian X, Kang JR, Ghaffari A, Liu SY, Belperio JA, Cheng G, Deng JC. Type I IFNs mediate development of postinfluenza bacterial pneumonia in mice. J Clin Invest. 2009 Jul; 119(7):1910-20. PMID: 19487810; PMCID: PMC2701856.
    23. Wang TS, Deng JC. Molecular and cellular aspects of sepsis-induced immunosuppression. J Mol Med (Berl). 2008 May; 86(5):495-506. PMID: 18259721.
      View in: PubMed
    24. Deng JC, Cheng G, Newstead MW, Zeng X, Kobayashi K, Flavell RA, Standiford TJ. Sepsis-induced suppression of lung innate immunity is mediated by IRAK-M. J Clin Invest. 2006 Sep; 116(9):2532-42. PMID: 16917541; PMCID: PMC1550278.
    25. Zeng X, Moore TA, Newstead MW, Deng JC, Kunkel SL, Luster AD, Standiford TJ. Interferon-inducible protein 10, but not monokine induced by gamma interferon, promotes protective type 1 immunity in murine Klebsiella pneumoniae pneumonia. Infect Immun. 2005 Dec; 73(12):8226-36. PMID: 16299319; PMCID: PMC1307052.
    26. Deng JC, Standiford TJ. The systemic response to lung infection. Clin Chest Med. 2005 Mar; 26(1):1-9. PMID: 15802160.
      View in: PubMed
    27. Zeng X, Moore TA, Newstead MW, Deng JC, Lukacs NW, Standiford TJ. IP-10 mediates selective mononuclear cell accumulation and activation in response to intrapulmonary transgenic expression and during adenovirus-induced pulmonary inflammation. J Interferon Cytokine Res. 2005 Feb; 25(2):103-12. PMID: 15695931.
      View in: PubMed
    28. Deng JC, Moore TA, Newstead MW, Zeng X, Krieg AM, Standiford TJ. CpG oligodeoxynucleotides stimulate protective innate immunity against pulmonary Klebsiella infection. J Immunol. 2004 Oct 15; 173(8):5148-55. PMID: 15470059; PMCID: PMC3001228.
    29. Deng JC, Zeng X, Newstead M, Moore TA, Tsai WC, Thannickal VJ, Standiford TJ. STAT4 is a critical mediator of early innate immune responses against pulmonary Klebsiella infection. J Immunol. 2004 Sep 15; 173(6):4075-83. PMID: 15356157; PMCID: PMC3001230.
    30. Tsai WC, Rodriguez ML, Young KS, Deng JC, Thannickal VJ, Tateda K, Hershenson MB, Standiford TJ. Azithromycin blocks neutrophil recruitment in Pseudomonas endobronchial infection. Am J Respir Crit Care Med. 2004 Dec 15; 170(12):1331-9. PMID: 15361366.
      View in: PubMed
    31. Standiford TJ, Deng JC. Immunomodulation for the prevention and treatment of lung infections. Semin Respir Crit Care Med. 2004 Feb; 25(1):95-108. PMID: 16088453.
      View in: PubMed
    32. Tateda K, Deng JC, Moore TA, Newstead MW, Paine R, Kobayashi N, Yamaguchi K, Standiford TJ. Hyperoxia mediates acute lung injury and increased lethality in murine Legionella pneumonia: the role of apoptosis. J Immunol. 2003 Apr 15; 170(8):4209-16. PMID: 12682254.
      View in: PubMed
    33. Deng JC, Baughman RP, Lynch JP. Cardiac involvement in sarcoidosis. Semin Respir Crit Care Med. 2002 Dec; 23(6):513-27. PMID: 16088647.
      View in: PubMed