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Chute John

TitleProfessor
InstitutionUniversity of California Los Angeles
DepartmentHematology-Oncology
Phone310-206-3037
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    Collapse Research 
    Collapse Research Activities and Funding
    Epidermal growth factor mitigates radiation-induced hematopoietic failure
    NIH/NIAID U01AI107333May 15, 2013 - Apr 30, 2018
    Role: Principal Investigator
    Semaphorin signaling regulates vascular and hematopoietic regeneration
    NIH/NHLBI R01HL086998Dec 1, 2006 - Nov 30, 2022
    Role: Principal Investigator
    The UCLA Center for Medical Countermeasures Against Radiation
    NIH/NIAID U19AI067769Aug 31, 2005 - Jul 31, 2020
    Role: Co-Principal Investigator
    Academic Training in Hematology
    NIH/NHLBI T32HL066992Jul 1, 2001 - Jul 31, 2018
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Chute JP. Autologous Stem Cell Transplantation for Multiple Myeloma: Underutilized but Highly Effective. J Natl Cancer Inst. 2019 Jan 01; 111(1):7-8. PMID: 29897483.
      View in: PubMed
    2. Himburg HA, Termini CM, Schlussel L, Kan J, Li M, Zhao L, Fang T, Sasine JP, Chang VY, Chute JP. Distinct Bone Marrow Sources of Pleiotrophin Control Hematopoietic Stem Cell Maintenance and Regeneration. Cell Stem Cell. 2018 Sep 06; 23(3):370-381.e5. PMID: 30100167.
      View in: PubMed
    3. Sasine JP, Himburg HA, Termini CM, Roos M, Tran E, Zhao L, Kan J, Li M, Zhang Y, de Barros SC, Rao DS, Counter CM, Chute JP. Wild-type Kras expands and exhausts hematopoietic stem cells. JCI Insight. 2018 Jun 07; 3(11). PMID: 29875320.
      View in: PubMed
    4. Piryani SO, Kam AYF, Kliassov EG, Chen BJ, Spector NL, Chute JP, Hsu DS, Chao NJ, Doan PL. Epidermal Growth Factor and Granulocyte Colony Stimulating Factor Signaling Are Synergistic for Hematopoietic Regeneration. Stem Cells. 2018 02; 36(2):252-264. PMID: 29086459.
      View in: PubMed
    5. Chang VY, Termini CM, Chute JP. Young endothelial cells revive aging blood. J Clin Invest. 2017 Nov 01; 127(11):3921-3922. PMID: 29035281.
      View in: PubMed
    6. Chai-Ho W, Chute JP. Paracrine regulation of normal and malignant hematopoiesis. Curr Opin Hematol. 2017 Jul; 24(4):329-335. PMID: 28594661.
      View in: PubMed
    7. Himburg HA, Doan PL, Quarmyne M, Yan X, Sasine J, Zhao L, Hancock GV, Kan J, Pohl KA, Tran E, Chao NJ, Harris JR, Chute JP. Dickkopf-1 promotes hematopoietic regeneration via direct and niche-mediated mechanisms. Nat Med. 2017 01; 23(1):91-99. PMID: 27918563.
      View in: PubMed
    8. Yan X, Himburg HA, Pohl K, Quarmyne M, Tran E, Zhang Y, Fang T, Kan J, Chao NJ, Zhao L, Doan PL, Chute JP. Deletion of the Imprinted Gene Grb10 Promotes Hematopoietic Stem Cell Self-Renewal and Regeneration. Cell Rep. 2016 11 01; 17(6):1584-1594. PMID: 27806297.
      View in: PubMed
    9. Sasine JP, Yeo KT, Chute JP. Concise Review: Paracrine Functions of Vascular Niche Cells in Regulating Hematopoietic Stem Cell Fate. Stem Cells Transl Med. 2017 Feb; 6(2):482-489. PMID: 28191767.
      View in: PubMed
    10. Koechlein CS, Harris JR, Lee TK, Weeks J, Fox RG, Zimdahl B, Ito T, Blevins A, Jung SH, Chute JP, Chourasia A, Covert MW, Reya T. High-resolution imaging and computational analysis of haematopoietic cell dynamics in vivo. Nat Commun. 2016 07 18; 7:12169. PMID: 27425143.
      View in: PubMed
    11. Himburg HA, Sasine J, Yan X, Kan J, Dressman H, Chute JP. A Molecular Profile of the Endothelial Cell Response to Ionizing Radiation. Radiat Res. 2016 08; 186(2):141-52. PMID: 27387861.
      View in: PubMed
    12. Michelotti GA, Tucker A, Swiderska-Syn M, Machado MV, Choi SS, Kruger L, Soderblom E, Thompson JW, Mayer-Salman M, Himburg HA, Moylan CA, Guy CD, Garman KS, Premont RT, Chute JP, Diehl AM. Pleiotrophin regulates the ductular reaction by controlling the migration of cells in liver progenitor niches. Gut. 2016 Apr; 65(4):683-92. PMID: 25596181; PMCID: PMC4504836.
    13. Quarmyne M, Doan PL, Himburg HA, Yan X, Nakamura M, Zhao L, Chao NJ, Chute JP. Protein tyrosine phosphatase-s regulates hematopoietic stem cell-repopulating capacity. J Clin Invest. 2015 Jan; 125(1):177-82. PMID: 25415437; PMCID: PMC4382260.
    14. Tuchman SA, Bacon WA, Huang LW, Long G, Rizzieri D, Horwitz M, Chute JP, Sullivan K, Morris Engemann A, Yopp A, Li Z, Corbet K, Chao N, Gasparetto C. Cyclophosphamide-based hematopoietic stem cell mobilization before autologous stem cell transplantation in newly diagnosed multiple myeloma. J Clin Apher. 2015 Jun; 30(3):176-82. PMID: 25293363; PMCID: PMC4523145.
    15. Lucas J, Dressman HK, Suchindran S, Nakamura M, Chao NJ, Himburg H, Minor K, Phillips G, Ross J, Abedi M, Terbrueggen R, Chute JP. A translatable predictor of human radiation exposure. PLoS One. 2014; 9(9):e107897. PMID: 25255453; PMCID: PMC4177872.
    16. Himburg HA, Yan X, Doan PL, Quarmyne M, Micewicz E, McBride W, Chao NJ, Slamon DJ, Chute JP. Pleiotrophin mediates hematopoietic regeneration via activation of RAS. J Clin Invest. 2014 Nov; 124(11):4753-8. PMID: 25250571.
      View in: PubMed
    17. Zheng L, Yan X, Suchindran S, Dressman H, Chute JP, Lucas J. Biological pathway selection through Bayesian integrative modeling. Stat Appl Genet Mol Biol. 2014 Aug; 13(4):435-57. PMID: 24937506.
      View in: PubMed
    18. Horwitz ME, Chao NJ, Rizzieri DA, Long GD, Sullivan KM, Gasparetto C, Chute JP, Morris A, McDonald C, Waters-Pick B, Stiff P, Wease S, Peled A, Snyder D, Cohen EG, Shoham H, Landau E, Friend E, Peleg I, Aschengrau D, Yackoubov D, Kurtzberg J, Peled T. Umbilical cord blood expansion with nicotinamide provides long-term multilineage engraftment. J Clin Invest. 2014 Jul; 124(7):3121-8. PMID: 24911148; PMCID: PMC4071379.
    19. Chute JP. NRF2 mitigates radiation-induced hematopoietic death. J Clin Invest. 2014 Mar; 124(3):960-1. PMID: 24569364; PMCID: PMC3938265.
    20. Doan PL, Chute JP. Ex vivo expansion of murine and human hematopoietic stem cells. Methods Mol Biol. 2014; 1185:211-21. PMID: 25062631.
      View in: PubMed
    21. Kanda J, Long GD, Gasparetto C, Horwitz ME, Sullivan KM, Chute JP, Morris A, Shafique M, Li Z, Chao NJ, Rizzieri DA. Reduced-intensity allogeneic transplantation using alemtuzumab from HLA-matched related, unrelated, or haploidentical related donors for patients with hematologic malignancies. Biol Blood Marrow Transplant. 2014 Feb; 20(2):257-63. PMID: 24269380; PMCID: PMC4140655.
    22. Doan PL, Himburg HA, Helms K, Russell JL, Fixsen E, Quarmyne M, Harris JR, Deoliviera D, Sullivan JM, Chao NJ, Kirsch DG, Chute JP. Epidermal growth factor regulates hematopoietic regeneration after radiation injury. Nat Med. 2013 Mar; 19(3):295-304. PMID: 23377280; PMCID: PMC3594347.
    23. Doan PL, Russell JL, Himburg HA, Helms K, Harris JR, Lucas J, Holshausen KC, Meadows SK, Daher P, Jeffords LB, Chao NJ, Kirsch DG, Chute JP. Tie2(+) bone marrow endothelial cells regulate hematopoietic stem cell regeneration following radiation injury. Stem Cells. 2013 Feb; 31(2):327-37. PMID: 23132593; PMCID: PMC3580267.
    24. Himburg HA, Harris JR, Ito T, Daher P, Russell JL, Quarmyne M, Doan PL, Helms K, Nakamura M, Fixsen E, Herradon G, Reya T, Chao NJ, Harroch S, Chute JP. Pleiotrophin regulates the retention and self-renewal of hematopoietic stem cells in the bone marrow vascular niche. Cell Rep. 2012 Oct 25; 2(4):964-75. PMID: 23084748; PMCID: PMC3696585.
    25. Spasojevic I, da Costa LR, Horwitz ME, Long GD, Sullivan KM, Chute JP, Gasparetto C, Morris A, Chao NJ, Rizzieri DA. Mini test dose of intravenous busulfan (busulfex(®)) in allogeneic non-myeloablative stem cell transplantation, followed by liquid chromatography tandem-mass spectrometry. Cancer Invest. 2012 Nov; 30(9):679-82. PMID: 23020519; PMCID: PMC3791921.
    26. Chute JP. To survive radiation injury, remember your aPCs. Nat Med. 2012 Jul 06; 18(7):1013-4. PMID: 22772550.
      View in: PubMed
    27. Kanda J, Chiou LW, Szabolcs P, Sempowski GD, Rizzieri DA, Long GD, Sullivan KM, Gasparetto C, Chute JP, Morris A, McPherson J, Hale J, Livingston JA, Broadwater G, Niedzwiecki D, Chao NJ, Horwitz ME. Immune recovery in adult patients after myeloablative dual umbilical cord blood, matched sibling, and matched unrelated donor hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2012 Nov; 18(11):1664-1676.e1. PMID: 22698485; PMCID: PMC3472115.
    28. LaBreche HG, Meadows SK, Nevins JR, Chute JP. Peripheral blood signatures of lead exposure. PLoS One. 2011; 6(8):e23043. PMID: 21829687; PMCID: PMC3148235.
    29. Kanda J, Rizzieri DA, Gasparetto C, Long GD, Chute JP, Sullivan KM, Morris A, Smith CA, Hogge DE, Nitta J, Song K, Niedzwiecki D, Chao NJ, Horwitz ME. Adult dual umbilical cord blood transplantation using myeloablative total body irradiation (1350 cGy) and fludarabine conditioning. Biol Blood Marrow Transplant. 2011 Jun; 17(6):867-74. PMID: 20868761; PMCID: PMC3877679.
    30. Meadows SK, Dressman HK, Daher P, Himburg H, Russell JL, Doan P, Chao NJ, Lucas J, Nevins JR, Chute JP. Diagnosis of partial body radiation exposure in mice using peripheral blood gene expression profiles. PLoS One. 2010 Jul 12; 5(7):e11535. PMID: 20634956; PMCID: PMC2902517.
    31. Chen BJ, Deoliveira D, Spasojevic I, Sempowski GD, Jiang C, Owzar K, Wang X, Gesty-Palmer D, Cline JM, Bourland JD, Dugan G, Meadows SK, Daher P, Muramoto G, Chute JP, Chao NJ. Growth hormone mitigates against lethal irradiation and enhances hematologic and immune recovery in mice and nonhuman primates. PLoS One. 2010 Jun 16; 5(6):e11056. PMID: 20585403; PMCID: PMC2886847.
    32. Araki H, Chute JP, Petro B, Halliday L, Hoffman R, Mahmud N. Bone marrow CD34+ cells expanded on human brain endothelial cells reconstitute lethally irradiated baboons in a variable manner. Leuk Lymphoma. 2010 Jun; 51(6):1121-7. PMID: 20470216.
      View in: PubMed
    33. Davids MS, Case C, Hornung R, Chao NJ, Chute JP, Coleman CN, Weisdorf D, Confer DL, Weinstock DM. Assessing surge capacity for radiation victims with marrow toxicity. Biol Blood Marrow Transplant. 2010 Oct; 16(10):1436-41. PMID: 20399880.
      View in: PubMed
    34. Muramoto GG, Russell JL, Safi R, Salter AB, Himburg HA, Daher P, Meadows SK, Doan P, Storms RW, Chao NJ, McDonnell DP, Chute JP. Inhibition of aldehyde dehydrogenase expands hematopoietic stem cells with radioprotective capacity. Stem Cells. 2010 Mar 31; 28(3):523-34. PMID: 20054864; PMCID: PMC3909217.
    35. Himburg HA, Muramoto GG, Daher P, Meadows SK, Russell JL, Doan P, Chi JT, Salter AB, Lento WE, Reya T, Chao NJ, Chute JP. Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells. Nat Med. 2010 Apr; 16(4):475-82. PMID: 20305662; PMCID: PMC3689427.
    36. Prasanna PG, Blakely WF, Bertho JM, Chute JP, Cohen EP, Goans RE, Grace MB, Lillis-Hearne PK, Lloyd DC, Lutgens LC, Meineke V, Ossetrova NI, Romanyukha A, Saba JD, Weisdorf DJ, Wojcik A, Yukihara EG, Pellmar TC. Synopsis of partial-body radiation diagnostic biomarkers and medical management of radiation injury workshop. Radiat Res. 2010 Feb; 173(2):245-53. PMID: 20095857.
      View in: PubMed
    37. Lee G, Muramoto GG, Chute JP, Marszalek PE. Nanomechanical fingerprints of gamma radiation damage to DNA. J Nanosci Nanotechnol. 2009 Dec; 9(12):7359-63. PMID: 19908788.
      View in: PubMed
    38. Chute JP, Ross JR, McDonnell DP. Minireview: Nuclear receptors, hematopoiesis, and stem cells. Mol Endocrinol. 2010 Jan; 24(1):1-10. PMID: 19934345; PMCID: PMC2802897.
    39. Gasparetto C, Gockerman JP, Diehl LF, de Castro CM, Moore JO, Long GD, Horwitz ME, Keogh G, Chute JP, Sullivan KM, Neuwirth R, Davis PH, Sutton LM, Anderson RD, Chao NJ, Rizzieri D. "Short course" bortezomib plus melphalan and prednisone as induction prior to transplant or as frontline therapy for nontransplant candidates in patients with previously untreated multiple myeloma. Biol Blood Marrow Transplant. 2010 Jan; 16(1):70-7. PMID: 19733251.
      View in: PubMed
    40. Zhao C, Chen A, Jamieson CH, Fereshteh M, Abrahamsson A, Blum J, Kwon HY, Kim J, Chute JP, Rizzieri D, Munchhof M, VanArsdale T, Beachy PA, Reya T. Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia. Nature. 2009 Apr 09; 458(7239):776-9. PMID: 19169242; PMCID: PMC2946231.
    41. Salter AB, Meadows SK, Muramoto GG, Himburg H, Doan P, Daher P, Russell L, Chen B, Chao NJ, Chute JP. Endothelial progenitor cell infusion induces hematopoietic stem cell reconstitution in vivo. Blood. 2009 Feb 26; 113(9):2104-7. PMID: 19141867; PMCID: PMC2651019.
    42. Safi R, Muramoto GG, Salter AB, Meadows S, Himburg H, Russell L, Daher P, Doan P, Leibowitz MD, Chao NJ, McDonnell DP, Chute JP. Pharmacological manipulation of the RAR/RXR signaling pathway maintains the repopulating capacity of hematopoietic stem cells in culture. Mol Endocrinol. 2009 Feb; 23(2):188-201. PMID: 19106195; PMCID: PMC2646618.
    43. Meadows SK, Dressman HK, Muramoto GG, Himburg H, Salter A, Wei Z, Ginsburg GS, Ginsburg G, Chao NJ, Nevins JR, Chute JP. Gene expression signatures of radiation response are specific, durable and accurate in mice and humans. PLoS One. 2008 Apr 02; 3(4):e1912. PMID: 18382685; PMCID: PMC2271127.
    44. Ke C, Jiang Y, Mieczkowski PA, Muramoto GG, Chute JP, Marszalek PE. Nanoscale detection of ionizing radiation damage to DNA by atomic force microscopy. Small. 2008 Feb; 4(2):288-94. PMID: 18247386.
      View in: PubMed
    45. Dressman HK, Muramoto GG, Chao NJ, Meadows S, Marshall D, Ginsburg GS, Nevins JR, Chute JP. Gene expression signatures that predict radiation exposure in mice and humans. PLoS Med. 2007 Apr; 4(4):e106. PMID: 17407386; PMCID: PMC1845155.
    46. Chute JP, Muramoto GG, Salter AB, Meadows SK, Rickman DW, Chen B, Himburg HA, Chao NJ. Transplantation of vascular endothelial cells mediates the hematopoietic recovery and survival of lethally irradiated mice. Blood. 2007 Mar 15; 109(6):2365-72. PMID: 17095624; PMCID: PMC1852197.
    47. Chute JP. Stem cell homing. Curr Opin Hematol. 2006 Nov; 13(6):399-406. PMID: 17053451.
      View in: PubMed
    48. Chute JP, Muramoto GG, Whitesides J, Colvin M, Safi R, Chao NJ, McDonnell DP. Inhibition of aldehyde dehydrogenase and retinoid signaling induces the expansion of human hematopoietic stem cells. Proc Natl Acad Sci U S A. 2006 Aug 01; 103(31):11707-12. PMID: 16857736; PMCID: PMC1544234.
    49. Muramoto GG, Chen B, Cui X, Chao NJ, Chute JP. Vascular endothelial cells produce soluble factors that mediate the recovery of human hematopoietic stem cells after radiation injury. Biol Blood Marrow Transplant. 2006 May; 12(5):530-40. PMID: 16635788.
      View in: PubMed
    50. Chute JP, Taylor E, Williams J, Kaye F, Venzon D, Johnson BE. A metabolic study of patients with lung cancer and hyponatremia of malignancy. Clin Cancer Res. 2006 Feb 01; 12(3 Pt 1):888-96. PMID: 16467103.
      View in: PubMed
    51. Chute JP, Muramoto GG, Dressman HK, Wolfe G, Chao NJ, Lin S. Molecular profile and partial functional analysis of novel endothelial cell-derived growth factors that regulate hematopoiesis. Stem Cells. 2006 May; 24(5):1315-27. PMID: 16373696.
      View in: PubMed
    52. Chute JP, Muramoto GG, Fung J, Oxford C. Soluble factors elaborated by human brain endothelial cells induce the concomitant expansion of purified human BM CD34+CD38- cells and SCID-repopulating cells. Blood. 2005 Jan 15; 105(2):576-83. PMID: 15345596.
      View in: PubMed
    53. Chute JP, Fung J, Muramoto G, Erwin R. Ex vivo culture rescues hematopoietic stem cells with long-term repopulating capacity following harvest from lethally irradiated mice. Exp Hematol. 2004 Mar; 32(3):308-17. PMID: 15003317.
      View in: PubMed
    54. Chute JP, Muramoto G, Fung J, Oxford C. Quantitative analysis demonstrates expansion of SCID-repopulating cells and increased engraftment capacity in human cord blood following ex vivo culture with human brain endothelial cells. Stem Cells. 2004; 22(2):202-15. PMID: 14990859.
      View in: PubMed
    55. Chute JP, Saini AA, Chute DJ, Wells MR, Clark WB, Harlan DM, Park J, Stull MK, Civin C, Davis TA. Ex vivo culture with human brain endothelial cells increases the SCID-repopulating capacity of adult human bone marrow. Blood. 2002 Dec 15; 100(13):4433-9. PMID: 12393435.
      View in: PubMed
    56. Chute JP, Clark W, Saini A, Wells M, Harlan D. Rescue of hematopoietic stem cells following high-dose radiation injury using ex vivo culture on endothelial monolayers. Mil Med. 2002 Feb; 167(2 Suppl):74-7. PMID: 11878265.
      View in: PubMed