Loading...

Ting Kang

Title(s)Professor and Chair of the Section of Orthodontics Division of Associated Clinical Specialities, California NanoSystems Institute
Phone(310) 206-6305
vCardDownload vCard
    Other Positions
    Title(s)Professor, Orthodontics


    Collapse Research 
    Collapse Research Activities and Funding
    NELL-1 Systemic Therapy for Osteoporosis
    NIH/NIAMS R01AR066782Aug 11, 2014 - Jul 31, 2019
    Role: Principal Investigator
    NELL-1, A Cbfa1 DOWNSTREAM TARGET, IN BONE FORMATION
    NIH/NIDCR R01DE016107Jul 1, 2004 - Jun 30, 2011
    Role: Principal Investigator
    Mechanistic Role of NELL-1 in Premature Suture Closure
    NIH/NIDCR R03DE014649Sep 1, 2002 - Aug 31, 2005
    Role: Principal Investigator
    NEL-2 GENE IN BONE FORMATION &CRANIAL SUTURE CLOSURES
    NIH/NIDCR K23DE000422Sep 1, 1999 - Aug 31, 2005
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Wang C, Tanjaya J, Shen J, Lee S, Bisht B, Pan HC, Pang S, Zhang Y, Berthiaume EA, Chen E, Da Lio AL, Zhang X, Ting K, Guo S, Soo C. PPAR? Knockdown Impairs Bone Morphogenetic Protein-2 (BMP2)-Induced Critical-Size Bone Defect Repair. Am J Pathol. 2018 Dec 26. PMID: 30593824.
      View in: PubMed
    2. Guo J, Zeng X, Miao J, Liu C, Wei F, Liu D, Zheng Z, Ting K, Wang C, Liu Y. MiRNA-218 regulates osteoclast differentiation and inflammation response in periodontitis rats through Mmp9. Cell Microbiol. 2018 Nov 16; e12979. PMID: 30444938.
      View in: PubMed
    3. Qi H, Kim JK, Ha P, Chen X, Chen E, Chen Y, Li J, Pan HC, Yu M, Mohazeb Y, Azer S, Baik L, Kwak JH, Ting K, Zhang X, Hu M, Soo C. Inactivation of Nell-1 in Chondrocytes Significantly Impedes Appendicular Skeletogenesis. J Bone Miner Res. 2018 Oct 23. PMID: 30352124.
      View in: PubMed
    4. Meyers CA, Xu J, Asatrian G, Ding C, Shen J, Broderick K, Ting K, Soo C, Peault B, James AW. WISP-1 drives bone formation at the expense of fat formation in human perivascular stem cells. Sci Rep. 2018 Oct 23; 8(1):15618. PMID: 30353078.
      View in: PubMed
    5. Song R, Murphy M, Li C, Ting K, Soo C, Zheng Z. Current development of biodegradable polymeric materials for biomedical applications. Drug Des Devel Ther. 2018; 12:3117-3145. PMID: 30288019.
      View in: PubMed
    6. Liu Y, Zeng X, Miao J, Liu C, Wei F, Liu D, Zheng Z, Ting K, Wang C, Guo J. Upregulation of long noncoding RNA MEG3 inhibits the osteogenic differentiation of periodontal ligament cells. J Cell Physiol. 2019 Apr; 234(4):4617-4626. PMID: 30256394.
      View in: PubMed
    7. Zhang L, Chang L, Xu J, Meyers CA, Yan N, Zou E, Ding C, Ting K, Soo C, Pang S, James AW. Frontal Bone Healing Is Sensitive to Wnt Signaling Inhibition via Lentiviral-Encoded Beta-Catenin Short Hairpin RNA. Tissue Eng Part A. 2018 Aug 20. PMID: 29929440.
      View in: PubMed
    8. Li C, Zheng Z, Ha P, Chen X, Jiang W, Sun S, Chen F, Asatrian G, Berthiaume EA, Kim JK, Chen EC, Pang S, Zhang X, Ting K, Soo C. Neurexin Superfamily Cell Membrane Receptor Contactin-Associated Protein Like-4 (Cntnap4) Is Involved in Neural EGFL-Like 1 (Nell-1)-Responsive Osteogenesis. J Bone Miner Res. 2018 Oct; 33(10):1813-1825. PMID: 29905970.
      View in: PubMed
    9. Shen J, Shrestha S, Rao PN, Asatrian G, Scott MA, Nguyen V, Giacomelli P, Soo C, Ting K, Eilber FC, Peault B, Dry SM, James AW. Corrigendum to "Pericytic mimicry in well-differentiated liposarcoma/atypical lipomatous tumor" (Hum Pathol 2016;54:92-99). Hum Pathol. 2018 Aug; 78:188. PMID: 29958690.
      View in: PubMed
    10. Zhang S, Liu Y, Zheng Z, Zeng X, Liu D, Wang C, Ting K. MicroRNA-223 Suppresses Osteoblast Differentiation by Inhibiting DHRS3. Cell Physiol Biochem. 2018; 47(2):667-679. PMID: 29794437.
      View in: PubMed
    11. Zhao H, Qin X, Zhang Q, Zhang X, Lin J, Ting K, Chen F. Nell-1-?E, a novel transcript of Nell-1, inhibits cell migration by interacting with enolase-1. J Cell Biochem. 2018 Jul; 119(7):5725-5733. PMID: 29388706.
      View in: PubMed
    12. Lipman K, Wang C, Ting K, Soo C, Zheng Z. Tendinopathy: injury, repair, and current exploration. Drug Des Devel Ther. 2018; 12:591-603. PMID: 29593382.
      View in: PubMed
    13. Jiang W, Ting K, Lee S, Zara JN, Song R, Li C, Chen E, Zhang X, Zhao Z, Soo C, Zheng Z. Fibromodulin reduces scar size and increases scar tensile strength in normal and excessive-mechanical-loading porcine cutaneous wounds. J Cell Mol Med. 2018 Apr; 22(4):2510-2513. PMID: 29392829.
      View in: PubMed
    14. Li C, Zheng Z, Zhang X, Asatrian G, Chen E, Song R, Culiat C, Ting K, Soo C. Nfatc1 Is a Functional Transcriptional Factor Mediating Nell-1-Induced Runx3 Upregulation in Chondrocytes. Int J Mol Sci. 2018 Jan 06; 19(1). PMID: 29316655.
      View in: PubMed
    15. Tanjaya J, Lord EL, Wang C, Zhang Y, Kim JK, Nguyen A, Baik L, Pan HC, Chen E, Kwak JH, Zhang X, Wu B, Soo C, Ting K. The Effects of Systemic Therapy of PEGylated NEL-Like Protein 1 (NELL-1) on Fracture Healing in Mice. Am J Pathol. 2018 Mar; 188(3):715-727. PMID: 29294300.
      View in: PubMed
    16. Li C, Zheng Z, Jiang J, Jiang W, Lee K, Berthiaume EA, Chen EC, Culiat CT, Zhou YH, Zhang X, Ting K, Soo C. Neural EGFL-Like 1 Regulates Cartilage Maturation through Runt-Related Transcription Factor 3-Mediated Indian Hedgehog Signaling. Am J Pathol. 2018 Feb; 188(2):392-403. PMID: 29137952.
      View in: PubMed
    17. Zheng Z, James AW, Li C, Jiang W, Wang JZ, Chang GX, Lee KS, Chen F, Berthiaume EA, Chen Y, Pan HC, Chen EC, Li W, Zhao Z, Zhang X, Ting K, Soo C. Fibromodulin reduces scar formation in adult cutaneous wounds by eliciting a fetal-like phenotype. Signal Transduct Target Ther. 2017; 2. PMID: 29201497.
      View in: PubMed
    18. Meyers CA, Xu J, Zhang L, Asatrian G, Ding C, Yan N, Broderick K, Sacks J, Goyal R, Zhang X, Ting K, Péault B, Soo C, James AW. Early Immunomodulatory Effects of Implanted Human Perivascular Stromal Cells During Bone Formation. Tissue Eng Part A. 2018 03; 24(5-6):448-457. PMID: 28683667.
      View in: PubMed
    19. James AW, Shen J, Tsuei R, Nguyen A, Khadarian K, Meyers CA, Pan HC, Li W, Kwak JH, Asatrian G, Culiat CT, Lee M, Ting K, Zhang X, Soo C. NELL-1 induces Sca-1+ mesenchymal progenitor cell expansion in models of bone maintenance and repair. JCI Insight. 2017 Jun 15; 2(12). PMID: 28614787.
      View in: PubMed
    20. Han SH, Choi W, Song J, Kim J, Lee S, Choi Y, Byun SE, Ahn T, Ahn H, Ding C, Baik L, Ward S, Ting K, Lee S. The Implication of Substance P in the Development of Tendinopathy: A Case Control Study. Int J Mol Sci. 2017 Jun 09; 18(6). PMID: 28598390.
      View in: PubMed
    21. Lee S, Wang C, Pan HC, Shrestha S, Meyers C, Ding C, Shen J, Chen E, Lee M, Soo C, Ting K, James AW. Combining Smoothened Agonist and NEL-Like Protein-1 Enhances Bone Healing. Plast Reconstr Surg. 2017 Jun; 139(6):1385-1396. PMID: 28198775.
      View in: PubMed
    22. Chen XY, Xu SZ, Wang XW, Yang XY, Ma L, Zhang L, Yang GJ, Yang F, Wang LH, Zhang XL, Ting K, Gao CY, Mou XZ, Gou ZR, Zou H. Systematic comparison of biologically active foreign ions-codoped calcium phosphate microparticles on osteogenic differentiation in rat osteoporotic and normal mesenchymal stem cells. Oncotarget. 2017 May 30; 8(22):36578-36590. PMID: 28402265.
      View in: PubMed
    23. Shen J, Chen X, Jia H, Meyers CA, Shrestha S, Asatrian G, Ding C, Tsuei R, Zhang X, Peault B, Ting K, Soo C, James AW. Effects of WNT3A and WNT16 on the Osteogenic and Adipogenic Differentiation of Perivascular Stem/Stromal Cells. Tissue Eng Part A. 2018 01; 24(1-2):68-80. PMID: 28463594.
      View in: PubMed
    24. Pan HC, Lee S, Ting K, Shen J, Wang C, Nguyen A, Berthiaume EA, Zara JN, Turner AS, Seim HB, Kwak JH, Zhang X, Soo C. Cyst-Like Osteolytic Formations in Recombinant Human Bone Morphogenetic Protein-2 (rhBMP-2) Augmented Sheep Spinal Fusion. Am J Pathol. 2017 Jul; 187(7):1485-1495. PMID: 28502475.
      View in: PubMed
    25. James AW, Zhang X, Crisan M, Hardy WR, Liang P, Meyers CA, Lobo S, Lagishetty V, Childers MK, Asatrian G, Ding C, Yen YH, Zou E, Ting K, Peault B, Soo C. Isolation and characterization of canine perivascular stem/stromal cells for bone tissue engineering. PLoS One. 2017; 12(5):e0177308. PMID: 28489940.
      View in: PubMed
    26. Li C, Jiang J, Zheng Z, Lee KS, Zhou Y, Chen E, Culiat CT, Qiao Y, Chen X, Ting K, Zhang X, Soo C. Neural EGFL-Like 1 Is a Downstream Regulator of Runt-Related Transcription Factor 2 in Chondrogenic Differentiation and Maturation. Am J Pathol. 2017 May; 187(5):963-972. PMID: 28302495.
      View in: PubMed
    27. Cheng N, Park J, Olson J, Kwon T, Lee D, Lim R, Ha S, Kim R, Zhang X, Ting K, Tetradis S, Hong C. Effects of Bisphosphonate Administration on Cleft Bone Graft in a Rat Model. Cleft Palate Craniofac J. 2017 11; 54(6):687-698. PMID: 28094562.
      View in: PubMed
    28. Shrestha S, Meyers C, Shen J, Giacomelli P, Scott MA, Soo C, Dry SM, Ting K, James AW. Ang-1 and Ang-2 expression in angiomyolipoma and PEComa family tumors. J Orthop. 2017 Mar; 14(1):154-160. PMID: 28053374.
      View in: PubMed
    29. Cheung T, Park J, Lee D, Kim C, Olson J, Javadi S, Lawson G, McCabe J, Moon W, Ting K, Hong C. Ability of mini-implant-facilitated micro-osteoperforations to accelerate tooth movement in rats. Am J Orthod Dentofacial Orthop. 2016 Dec; 150(6):958-967. PMID: 27894545.
      View in: PubMed
    30. Shrestha S, Shen J, Giacomelli P, Scott MA, Soo C, Ting K, Péault B, Dry SM, James AW. Ang-2 but not Ang-1 expression in perivascular soft tissue tumors. J Orthop. 2017 Mar; 14(1):147-153. PMID: 27942190.
      View in: PubMed
    31. Lee S, Shen J, Pan HC, Shrestha S, Asatrian G, Nguyen A, Meyers C, Nguyen V, Lee M, Soo C, Ting K, James AW. Calvarial Defect Healing Induced by Small Molecule Smoothened Agonist. Tissue Eng Part A. 2016 12; 22(23-24):1357-1366. PMID: 27702396.
      View in: PubMed
    32. Zheng Z, Zhang X, Dang C, Beanes S, Chang GX, Chen Y, Li CS, Lee KS, Ting K, Soo C. Fibromodulin Is Essential for Fetal-Type Scarless Cutaneous Wound Healing. Am J Pathol. 2016 11; 186(11):2824-2832. PMID: 27665369.
      View in: PubMed
    33. Wing Moon Lam R, Abbah SA, Ming W, Naidu M, Ng F, Tao H, Goh Cho Hong J, Ting K, Hee Kit W. Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery. J Vis Exp. 2016 08 22; (114). PMID: 27585207.
      View in: PubMed
    34. James AW, Hindle P, Murray IR, West CC, Tawonsawatruk T, Shen J, Asatrian G, Zhang X, Nguyen V, Simpson AH, Ting K, Péault B, Soo C. Pericytes for the treatment of orthopedic conditions. Pharmacol Ther. 2017 03; 171:93-103. PMID: 27510330.
      View in: PubMed
    35. Shen J, Meyers CA, Shrestha S, Singh A, LaChaud G, Nguyen V, Asatrian G, Federman N, Bernthal N, Eilber FC, Dry SM, Ting K, Soo C, James AW. Sclerostin expression in skeletal sarcomas. Hum Pathol. 2016 12; 58:24-34. PMID: 27498059.
      View in: PubMed
    36. Lee H, Nguyen A, Hong C, Hoang P, Pham J, Ting K. Biomechanical effects of maxillary expansion on a patient with cleft palate: A finite element analysis. Am J Orthod Dentofacial Orthop. 2016 Aug; 150(2):313-23. PMID: 27476365.
      View in: PubMed
    37. Zhang Y, Dong R, Park Y, Bohner M, Zhang X, Ting K, Soo C, Wu BM. Controlled release of NELL-1 protein from chitosan/hydroxyapatite-modified TCP particles. Int J Pharm. 2016 Sep 10; 511(1):79-89. PMID: 27349789.
      View in: PubMed
    38. Tanjaya J, Zhang Y, Lee S, Shi J, Chen E, Ang P, Zhang X, Tetradis S, Ting K, Wu B, Soo C, Kwak JH. Efficacy of Intraperitoneal Administration of PEGylated NELL-1 for Bone Formation. Biores Open Access. 2016; 5(1):159-70. PMID: 27354930; PMCID: PMC4921932.
    39. James AW, Chiang M, Asatrian G, Shen J, Goyal R, Chung CG, Chang L, Shrestha S, Turner AS, Seim HB, Zhang X, Wu BM, Ting K, Soo C. Vertebral Implantation of NELL-1 Enhances Bone Formation in an Osteoporotic Sheep Model. Tissue Eng Part A. 2016 06; 22(11-12):840-9. PMID: 27113550; PMCID: PMC4913506 [Available on 06/01/17].
    40. James AW, LaChaud G, Shen J, Asatrian G, Nguyen V, Zhang X, Ting K, Soo C. A Review of the Clinical Side Effects of Bone Morphogenetic Protein-2. Tissue Eng Part B Rev. 2016 08; 22(4):284-97. PMID: 26857241.
      View in: PubMed
    41. Shi J, Lee S, Uyeda M, Tanjaya J, Kim JK, Pan HC, Reese P, Stodieck L, Lin A, Ting K, Kwak JH, Soo C. Guidelines for Dual Energy X-Ray Absorptiometry Analysis of Trabecular Bone-Rich Regions in Mice: Improved Precision, Accuracy, and Sensitivity for Assessing Longitudinal Bone Changes. Tissue Eng Part C Methods. 2016 05; 22(5):451-63. PMID: 26956416; PMCID: PMC4870654 [Available on 05/01/17].
    42. Shen J, Shrestha S, Rao PN, Asatrian G, Scott MA, Nguyen V, Giacomelli P, Soo C, Ting K, Eilber FC, Peault B, Dry SM, James AW. Pericytic mimicry in well-differentiated liposarcoma/atypical lipomatous tumor. Hum Pathol. 2016 08; 54:92-9. PMID: 27063472.
      View in: PubMed
    43. Guo M, James AW, Kwak JH, Shen J, Yokoyama KK, Ting K, Soo CB, Chiu RH. Cyclophilin A (CypA) Plays Dual Roles in Regulation of Bone Anabolism and Resorption. Sci Rep. 2016 Mar 02; 6:22378. PMID: 26932182; PMCID: PMC4774113.
    44. Li CS, Zhang X, Péault B, Jiang J, Ting K, Soo C, Zhou YH. Accelerated Chondrogenic Differentiation of Human Perivascular Stem Cells with NELL-1. Tissue Eng Part A. 2016 Feb; 22(3-4):272-85. PMID: 26700847.
      View in: PubMed
    45. Li CS, Yang P, Ting K, Aghaloo T, Lee S, Zhang Y, Khalilinejad K, Murphy MC, Pan HC, Zhang X, Wu B, Zhou YH, Zhao Z, Zheng Z, Soo C. Fibromodulin reprogrammed cells: A novel cell source for bone regeneration. Biomaterials. 2016 Mar; 83:194-206. PMID: 26774565.
      View in: PubMed
    46. Shen J, James AW, Zhang X, Pang S, Zara JN, Asatrian G, Chiang M, Lee M, Khadarian K, Nguyen A, Lee KS, Siu RK, Tetradis S, Ting K, Soo C. Novel Wnt Regulator NEL-Like Molecule-1 Antagonizes Adipogenesis and Augments Osteogenesis Induced by Bone Morphogenetic Protein 2. Am J Pathol. 2016 Feb; 186(2):419-34. PMID: 26772960; PMCID: PMC4729267 [Available on 02/01/17].
    47. Shen J, LaChaud G, Shrestha S, Asatrian G, Zhang X, Dry SM, Soo C, Ting K, James AW. NELL-1 expression in tumors of cartilage. J Orthop. 2015 Dec; 12(Suppl 2):S223-9. PMID: 27047227; PMCID: PMC4796526 [Available on 12/01/16].
    48. Shen J, Shrestha S, Yen YH, Scott MA, Soo C, Ting K, Peault B, Dry SM, James AW. The pericyte antigen RGS5 in perivascular soft tissue tumors. Hum Pathol. 2016 Jan; 47(1):121-31. PMID: 26558691.
      View in: PubMed
    49. Lee S, Zhang X, Shen J, James AW, Chung CG, Hardy R, Li C, Girgius C, Zhang Y, Stoker D, Wang H, Wu BM, Peault B, Ting K, Soo C. Brief Report: Human Perivascular Stem Cells and Nel-Like Protein-1 Synergistically Enhance Spinal Fusion in Osteoporotic Rats. Stem Cells. 2015 Oct; 33(10):3158-63. PMID: 26173400.
      View in: PubMed
    50. Shen J, Shrestha S, Yen YH, Scott MA, Asatrian G, Barnhill R, Lugassy C, Soo C, Ting K, Peault B, Dry SM, James AW. Pericyte antigens in angiomyolipoma and PEComa family tumors. Med Oncol. 2015 Aug; 32(8):210. PMID: 26123600.
      View in: PubMed
    51. James AW, Shen J, Zhang X, Asatrian G, Goyal R, Kwak JH, Jiang L, Bengs B, Culiat CT, Turner AS, Seim Iii HB, Wu BM, Lyons K, Adams JS, Ting K, Soo C. NELL-1 in the treatment of osteoporotic bone loss. Nat Commun. 2015 Jun 17; 6:7362. PMID: 26082355; PMCID: PMC4557288.
    52. Shen J, Shrestha S, Yen YH, Asatrian G, Mravic M, Soo C, Ting K, Dry SM, Peault B, James AW. Pericyte Antigens in Perivascular Soft Tissue Tumors. Int J Surg Pathol. 2015 Dec; 23(8):638-48. PMID: 26085647.
      View in: PubMed
    53. Chung CG, James AW, Asatrian G, Chang L, Nguyen A, Le K, Bayani G, Lee R, Stoker D, Pang S, Zhang X, Ting K, Péault B, Soo C. Human perivascular stem cell-based bone graft substitute induces rat spinal fusion. Stem Cells Transl Med. 2015 May; 4(5):538. PMID: 25926331.
      View in: PubMed
    54. Kwak JH, Zhang Y, Park J, Chen E, Shen J, Chawan C, Tanjaya J, Lee S, Zhang X, Wu BM, Ting K, Soo C. Pharmacokinetics and osteogenic potential of PEGylated NELL-1 in vivo after systemic administration. Biomaterials. 2015 Jul; 57:73-83. PMID: 25913252; PMCID: PMC4426150.
    55. Guo M, Shen J, Kwak JH, Choi B, Lee M, Hu S, Zhang X, Ting K, Soo CB, Chiu RH. Novel role for cyclophilin A in regulation of chondrogenic commitment and endochondral ossification. Mol Cell Biol. 2015 Jun; 35(12):2119-30. PMID: 25870110; PMCID: PMC4438250.
    56. Shen J, LaChaud G, Khadarian K, Shrestha S, Zhang X, Soo C, Ting K, Dry SM, James AW. NELL-1 expression in benign and malignant bone tumors. Biochem Biophys Res Commun. 2015 May 01; 460(2):368-74. PMID: 25791475.
      View in: PubMed
    57. Pang S, Shen J, Liu Y, Chen F, Zheng Z, James AW, Hsu CY, Zhang H, Lee KS, Wang C, Li C, Chen X, Jia H, Zhang X, Soo C, Ting K. Proliferation and osteogenic differentiation of mesenchymal stem cells induced by a short isoform of NELL-1. Stem Cells. 2015 Mar; 33(3):904-15. PMID: 25376942; PMCID: PMC4410844.
    58. Zheng Z, Jian J, Velasco O, Hsu CY, Zhang K, Levin A, Murphy M, Zhang X, Ting K, Soo C. Fibromodulin Enhances Angiogenesis during Cutaneous Wound Healing. Plast Reconstr Surg Glob Open. 2014 Dec; 2(12):e275. PMID: 25587509; PMCID: PMC4292257.
    59. Chung CG, James AW, Asatrian G, Chang L, Nguyen A, Le K, Bayani G, Lee R, Stoker D, Zhang X, Ting K, Péault B, Soo C. Human perivascular stem cell-based bone graft substitute induces rat spinal fusion. Stem Cells Transl Med. 2014 Oct; 3(10):1231-41. PMID: 25154782; PMCID: PMC4181396.
    60. Velasco O, James AW, Asatrian G, Ajalat M, Pritchard T, Novshadian S, Murthy A, Bayani G, Zhang X, Ting K, Soo C. High resolution x-ray: a reliable approach for quantifying osteoporosis in a rodent model. Biores Open Access. 2014 Aug 01; 3(4):192-6. PMID: 25126483; PMCID: PMC4120930.
    61. James AW, Shen J, Khadarian K, Pang S, Chung G, Goyal R, Asatrian G, Velasco O, Kim J, Zhang X, Ting K, Soo C. Lentiviral delivery of PPAR? shRNA alters the balance of osteogenesis and adipogenesis, improving bone microarchitecture. Tissue Eng Part A. 2014 Oct; 20(19-20):2699-710. PMID: 24785569; PMCID: PMC4195482.
    62. Zhang Y, Velasco O, Zhang X, Ting K, Soo C, Wu BM. Bioactivity and circulation time of PEGylated NELL-1 in mice and the potential for osteoporosis therapy. Biomaterials. 2014 Aug; 35(24):6614-21. PMID: 24818884; PMCID: PMC4077898.
    63. Zheng Z, Lee KS, Zhang X, Nguyen C, Hsu C, Wang JZ, Rackohn TM, Enjamuri DR, Murphy M, Ting K, Soo C. Fibromodulin-deficiency alters temporospatial expression patterns of transforming growth factor-ß ligands and receptors during adult mouse skin wound healing. PLoS One. 2014; 9(6):e90817. PMID: 24603701; PMCID: PMC3948369.
    64. Nakamura Y, Hasebe A, Takahashi K, Iijima M, Yoshimoto N, Maturana AD, Ting K, Kuroda S, Niimi T. Oligomerization-induced conformational change in the C-terminal region of Nel-like molecule 1 (NELL1) protein is necessary for the efficient mediation of murine MC3T3-E1 cell adhesion and spreading. J Biol Chem. 2014 Apr 04; 289(14):9781-94. PMID: 24563467; PMCID: PMC3975024.
    65. Islahudin F, Tindall SM, Mellor IR, Swift K, Christensen HE, Fone KC, Pleass RJ, Ting KN, Avery SV. The antimalarial drug quinine interferes with serotonin biosynthesis and action. Sci Rep. 2014 Jan 09; 4:3618. PMID: 24402577; PMCID: PMC3885885.
    66. Shen J, James AW, Zara JN, Asatrian G, Khadarian K, Zhang JB, Ho S, Kim HJ, Ting K, Soo C. BMP2-induced inflammation can be suppressed by the osteoinductive growth factor NELL-1. Tissue Eng Part A. 2013 Nov; 19(21-22):2390-401. PMID: 23758588; PMCID: PMC3807546.
    67. Jian J, Zheng Z, Zhang K, Rackohn TM, Hsu C, Levin A, Enjamuri DR, Zhang X, Ting K, Soo C. Fibromodulin promoted in vitro and in vivo angiogenesis. Biochem Biophys Res Commun. 2013 Jul 05; 436(3):530-535. PMID: 23770359; PMCID: PMC4007216.
    68. Chang J, Liu F, Lee M, Wu B, Ting K, Zara JN, Soo C, Al Hezaimi K, Zou W, Chen X, Mooney DJ, Wang CY. NF-?B inhibits osteogenic differentiation of mesenchymal stem cells by promoting ß-catenin degradation. Proc Natl Acad Sci U S A. 2013 Jun 04; 110(23):9469-74. PMID: 23690607; PMCID: PMC3677422.
    69. Askarinam A, James AW, Zara JN, Goyal R, Corselli M, Pan A, Liang P, Chang L, Rackohn T, Stoker D, Zhang X, Ting K, Péault B, Soo C. Human perivascular stem cells show enhanced osteogenesis and vasculogenesis with Nel-like molecule I protein. Tissue Eng Part A. 2013 Jun; 19(11-12):1386-97. PMID: 23406369; PMCID: PMC3638559.
    70. Kwak J, Zara JN, Chiang M, Ngo R, Shen J, James AW, Le KM, Moon C, Zhang X, Gou Z, Ting K, Soo C. NELL-1 injection maintains long-bone quantity and quality in an ovariectomy-induced osteoporotic senile rat model. Tissue Eng Part A. 2013 Feb; 19(3-4):426-36. PMID: 23083222; PMCID: PMC3542871.
    71. Shen J, James AW, Chung J, Lee K, Zhang JB, Ho S, Lee KS, Kim TM, Niimi T, Kuroda S, Ting K, Soo C. NELL-1 promotes cell adhesion and differentiation via Integrinß1. J Cell Biochem. 2012 Dec; 113(12):3620-8. PMID: 22807400.
      View in: PubMed
    72. Liu Y, Zheng Z, Zara JN, Hsu C, Soofer DE, Lee KS, Siu RK, Miller LS, Zhang X, Carpenter D, Wang C, Ting K, Soo C. The antimicrobial and osteoinductive properties of silver nanoparticle/poly (DL-lactic-co-glycolic acid)-coated stainless steel. Biomaterials. 2012 Dec; 33(34):8745-56. PMID: 22959466.
      View in: PubMed
    73. James AW, Zara JN, Corselli M, Askarinam A, Zhou AM, Hourfar A, Nguyen A, Megerdichian S, Asatrian G, Pang S, Stoker D, Zhang X, Wu B, Ting K, Péault B, Soo C. An abundant perivascular source of stem cells for bone tissue engineering. Stem Cells Transl Med. 2012 Sep; 1(9):673-84. PMID: 23197874; PMCID: PMC3659737.
    74. Chen F, Walder B, James AW, Soofer DE, Soo C, Ting K, Zhang X. NELL-1-dependent mineralisation of Saos-2 human osteosarcoma cells is mediated via c-Jun N-terminal kinase pathway activation. Int Orthop. 2012 Oct; 36(10):2181-7. PMID: 22797704; PMCID: PMC3460081.
    75. Guo X, Peng J, Wang Y, Wang A, Zhang X, Yuan M, Zhang L, Zhao B, Liu B, Fan M, Xue J, Guo Q, Xu W, Lu Q, Ting K, Lu S. NELL1 promotes bone regeneration in polyethylene particle-induced osteolysis. Tissue Eng Part A. 2012 Jul; 18(13-14):1344-51. PMID: 22404332.
      View in: PubMed
    76. Hasebe A, Nakamura Y, Tashima H, Takahashi K, Iijima M, Yoshimoto N, Ting K, Kuroda S, Niimi T. The C-terminal region of NELL1 mediates osteoblastic cell adhesion through integrin a3ß1. FEBS Lett. 2012 Jul 30; 586(16):2500-6. PMID: 22728432.
      View in: PubMed
    77. James AW, Zara JN, Zhang X, Askarinam A, Goyal R, Chiang M, Yuan W, Chang L, Corselli M, Shen J, Pang S, Stoker D, Wu B, Ting K, Péault B, Soo C. Perivascular stem cells: a prospectively purified mesenchymal stem cell population for bone tissue engineering. Stem Cells Transl Med. 2012 Jun; 1(6):510-9. PMID: 23197855; PMCID: PMC3659717.
    78. James AW, Zara JN, Corselli M, Chiang M, Yuan W, Nguyen V, Askarinam A, Goyal R, Siu RK, Scott V, Lee M, Ting K, Péault B, Soo C. Use of human perivascular stem cells for bone regeneration. J Vis Exp. 2012 May 25; (63):e2952. PMID: 22664543; PMCID: PMC3466949.
    79. Zheng Z, Jian J, Zhang X, Zara JN, Yin W, Chiang M, Liu Y, Wang J, Pang S, Ting K, Soo C. Reprogramming of human fibroblasts into multipotent cells with a single ECM proteoglycan, fibromodulin. Biomaterials. 2012 Aug; 33(24):5821-31. PMID: 22622142.
      View in: PubMed
    80. Cowan CM, Zhang X, James AW, Kim TM, Sun N, Wu B, Ting K, Soo C. NELL-1 increases pre-osteoblast mineralization using both phosphate transporter Pit1 and Pit2. Biochem Biophys Res Commun. 2012 Jun 08; 422(3):351-7. PMID: 22580275.
      View in: PubMed
    81. Hasebe A, Tashima H, Ide T, Iijima M, Yoshimoto N, Ting K, Kuroda S, Niimi T. Efficient production and characterization of recombinant human NELL1 protein in human embryonic kidney 293-F cells. Mol Biotechnol. 2012 May; 51(1):58-66. PMID: 21814724.
      View in: PubMed
    82. James AW, Pang S, Askarinam A, Corselli M, Zara JN, Goyal R, Chang L, Pan A, Shen J, Yuan W, Stoker D, Zhang X, Adams JS, Ting K, Soo C. Additive effects of sonic hedgehog and Nell-1 signaling in osteogenic versus adipogenic differentiation of human adipose-derived stromal cells. Stem Cells Dev. 2012 Aug 10; 21(12):2170-8. PMID: 22264144; PMCID: PMC3411358.
    83. Scott MA, Levi B, Askarinam A, Nguyen A, Rackohn T, Ting K, Soo C, James AW. Brief review of models of ectopic bone formation. Stem Cells Dev. 2012 Mar 20; 21(5):655-67. PMID: 22085228; PMCID: PMC3295855.
    84. Zhang X, Ting K, Pathmanathan D, Ko T, Chen W, Chen F, Lee H, James AW, Siu RK, Shen J, Culiat CT, Soo C. Calvarial cleidocraniodysplasia-like defects with ENU-induced Nell-1 deficiency. J Craniofac Surg. 2012 Jan; 23(1):61-6. PMID: 22337375; PMCID: PMC3282020.
    85. Siu RK, Zara JN, Hou Y, James AW, Kwak J, Zhang X, Ting K, Wu BM, Soo C, Lee M. NELL-1 promotes cartilage regeneration in an in vivo rabbit model. Tissue Eng Part A. 2012 Feb; 18(3-4):252-61. PMID: 21902605; PMCID: PMC3267973.
    86. Chen F, Zhang X, Sun S, Zara JN, Zou X, Chiu R, Culiat CT, Ting K, Soo C. NELL-1, an osteoinductive factor, is a direct transcriptional target of Osterix. PLoS One. 2011; 6(9):e24638. PMID: 21931789; PMCID: PMC3172249.
    87. Zhang X, Péault B, Chen W, Li W, Corselli M, James AW, Lee M, Siu RK, Shen P, Zheng Z, Shen J, Kwak J, Zara JN, Chen F, Zhang H, Yin Z, Wu B, Ting K, Soo C. The Nell-1 growth factor stimulates bone formation by purified human perivascular cells. Tissue Eng Part A. 2011 Oct; 17(19-20):2497-509. PMID: 21615216; PMCID: PMC3179623.
    88. Zou X, Shen J, Chen F, Ting K, Zheng Z, Pang S, Zara JN, Adams JS, Soo C, Zhang X. NELL-1 binds to APR3 affecting human osteoblast proliferation and differentiation. FEBS Lett. 2011 Aug 04; 585(15):2410-8. PMID: 21723284; PMCID: PMC3209538.
    89. James AW, Pan A, Chiang M, Zara JN, Zhang X, Ting K, Soo C. A new function of Nell-1 protein in repressing adipogenic differentiation. Biochem Biophys Res Commun. 2011 Jul 22; 411(1):126-31. PMID: 21723263; PMCID: PMC3166249.
    90. Chen W, Zhang X, Siu RK, Chen F, Shen J, Zara JN, Culiat CT, Tetradis S, Ting K, Soo C. Nfatc2 is a primary response gene of Nell-1 regulating chondrogenesis in ATDC5 cells. J Bone Miner Res. 2011 Jun; 26(6):1230-41. PMID: 21611965; PMCID: PMC3312756.
    91. Zhang X, Ting K, Bessette CM, Culiat CT, Sung SJ, Lee H, Chen F, Shen J, Wang JJ, Kuroda S, Soo C. Nell-1, a key functional mediator of Runx2, partially rescues calvarial defects in Runx2(+/-) mice. J Bone Miner Res. 2011 Apr; 26(4):777-91. PMID: 20939017; PMCID: PMC3179324.
    92. Zara JN, Siu RK, Zhang X, Shen J, Ngo R, Lee M, Li W, Chiang M, Chung J, Kwak J, Wu BM, Ting K, Soo C. High doses of bone morphogenetic protein 2 induce structurally abnormal bone and inflammation in vivo. Tissue Eng Part A. 2011 May; 17(9-10):1389-99. PMID: 21247344; PMCID: PMC3079169.
    93. Siu RK, Lu SS, Li W, Whang J, McNeill G, Zhang X, Wu BM, Turner AS, Seim HB, Hoang P, Wang JC, Gertzman AA, Ting K, Soo C. Nell-1 protein promotes bone formation in a sheep spinal fusion model. Tissue Eng Part A. 2011 Apr; 17(7-8):1123-35. PMID: 21128865; PMCID: PMC3063712.
    94. Li W, Zara JN, Siu RK, Lee M, Aghaloo T, Zhang X, Wu BM, Gertzman AA, Ting K, Soo C. Nell-1 enhances bone regeneration in a rat critical-sized femoral segmental defect model. Plast Reconstr Surg. 2011 Feb; 127(2):580-7. PMID: 21285762; PMCID: PMC3089952.
    95. Khorasani H, Zheng Z, Nguyen C, Zara J, Zhang X, Wang J, Ting K, Soo C. A quantitative approach to scar analysis. Am J Pathol. 2011 Feb; 178(2):621-8. PMID: 21281794; PMCID: PMC3070584.
    96. Zheng Z, Nguyen C, Zhang X, Khorasani H, Wang JZ, Zara JN, Chu F, Yin W, Pang S, Le A, Ting K, Soo C. Delayed wound closure in fibromodulin-deficient mice is associated with increased TGF-ß3 signaling. J Invest Dermatol. 2011 Mar; 131(3):769-78. PMID: 21191417; PMCID: PMC4073663.
    97. Xue J, Peng J, Yuan M, Wang A, Zhang L, Liu S, Fan M, Wang Y, Xu W, Ting K, Zhang X, Lu S. NELL1 promotes high-quality bone regeneration in rat femoral distraction osteogenesis model. Bone. 2011 Mar 01; 48(3):485-95. PMID: 20959151.
      View in: PubMed
    98. Yang X, Gan Y, Gao X, Zhao L, Gao C, Zhang X, Feng Y, Ting K, Gou Z. Preparation and characterization of trace elements-multidoped injectable biomimetic materials for minimally invasive treatment of osteoporotic bone trauma. J Biomed Mater Res A. 2010 Dec 15; 95(4):1170-81. PMID: 20878988.
      View in: PubMed
    99. Zheng Z, Yin W, Zara JN, Li W, Kwak J, Mamidi R, Lee M, Siu RK, Ngo R, Wang J, Carpenter D, Zhang X, Wu B, Ting K, Soo C. The use of BMP-2 coupled - Nanosilver-PLGA composite grafts to induce bone repair in grossly infected segmental defects. Biomaterials. 2010 Dec; 31(35):9293-300. PMID: 20864167; PMCID: PMC3202602.
    100. Li W, Lee M, Whang J, Siu RK, Zhang X, Liu C, Wu BM, Wang JC, Ting K, Soo C. Delivery of lyophilized Nell-1 in a rat spinal fusion model. Tissue Eng Part A. 2010 Sep; 16(9):2861-70. PMID: 20528102; PMCID: PMC2928135.
    101. Lee M, Siu RK, Ting K, Wu BM. Effect of Nell-1 delivery on chondrocyte proliferation and cartilaginous extracellular matrix deposition. Tissue Eng Part A. 2010 May; 16(5):1791-800. PMID: 20028218.
      View in: PubMed
    102. Aghaloo T, Cowan CM, Zhang X, Freymiller E, Soo C, Wu B, Ting K, Zhang Z. The effect of NELL1 and bone morphogenetic protein-2 on calvarial bone regeneration. J Oral Maxillofac Surg. 2010 Feb; 68(2):300-8. PMID: 20116699; PMCID: PMC3113462.
    103. Lee H, Ting K, Nelson M, Sun N, Sung SJ. Maxillary expansion in customized finite element method models. Am J Orthod Dentofacial Orthop. 2009 Sep; 136(3):367-74. PMID: 19732671.
      View in: PubMed
    104. Lee M, Li W, Siu RK, Whang J, Zhang X, Soo C, Ting K, Wu BM. Biomimetic apatite-coated alginate/chitosan microparticles as osteogenic protein carriers. Biomaterials. 2009 Oct; 30(30):6094-101. PMID: 19674782; PMCID: PMC2745535.
    105. Chow A, Lee HF, Trahar M, Kawamoto H, Vastardis H, Ting K. Cephalometric evaluation of the craniofacial complex in patients treated with an intraoral distraction osteogenesis device: a long-term study. Am J Orthod Dentofacial Orthop. 2008 12; 134(6):724-31. PMID: 19061798; PMCID: PMC2866070.
    106. Warren SM, Walder B, Dec W, Longaker MT, Ting K. Confocal laser scanning microscopic analysis of collagen scaffolding patterns in cranial sutures. J Craniofac Surg. 2008 Jan; 19(1):198-203. PMID: 18216689; PMCID: PMC2705761.
    107. Bokui N, Otani T, Igarashi K, Kaku J, Oda M, Nagaoka T, Seno M, Tatematsu K, Okajima T, Matsuzaki T, Ting K, Tanizawa K, Kuroda S. Involvement of MAPK signaling molecules and Runx2 in the NELL1-induced osteoblastic differentiation. FEBS Lett. 2008 Jan 23; 582(2):365-71. PMID: 18082140; PMCID: PMC2959102.
    108. Aghaloo T, Jiang X, Soo C, Zhang Z, Zhang X, Hu J, Pan H, Hsu T, Wu B, Ting K, Zhang X. A study of the role of nell-1 gene modified goat bone marrow stromal cells in promoting new bone formation. Mol Ther. 2007 Oct; 15(10):1872-80. PMID: 17653100; PMCID: PMC2705762.
    109. Cowan CM, Jiang X, Hsu T, Soo C, Zhang B, Wang JZ, Kuroda S, Wu B, Zhang Z, Zhang X, Ting K. Synergistic effects of Nell-1 and BMP-2 on the osteogenic differentiation of myoblasts. J Bone Miner Res. 2007 Jun; 22(6):918-30. PMID: 17352654; PMCID: PMC2866074.
    110. Cowan CM, Aghaloo T, Chou YF, Walder B, Zhang X, Soo C, Ting K, Wu B. MicroCT evaluation of three-dimensional mineralization in response to BMP-2 doses in vitro and in critical sized rat calvarial defects. Tissue Eng. 2007 Mar; 13(3):501-12. PMID: 17319794.
      View in: PubMed
    111. Truong T, Zhang X, Pathmanathan D, Soo C, Ting K. Craniosynostosis-associated gene nell-1 is regulated by runx2. J Bone Miner Res. 2007 Jan; 22(1):7-18. PMID: 17042739.
      View in: PubMed
    112. Lu SS, Zhang X, Soo C, Hsu T, Napoli A, Aghaloo T, Wu BM, Tsou P, Ting K, Wang JC. The osteoinductive properties of Nell-1 in a rat spinal fusion model. Spine J. 2007 Jan-Feb; 7(1):50-60. PMID: 17197333.
      View in: PubMed
    113. Aghaloo T, Cowan CM, Chou YF, Zhang X, Lee H, Miao S, Hong N, Kuroda S, Wu B, Ting K, Soo C. Nell-1-induced bone regeneration in calvarial defects. Am J Pathol. 2006 Sep; 169(3):903-15. PMID: 16936265; PMCID: PMC1698834.
    114. Zhang X, Cowan CM, Jiang X, Soo C, Miao S, Carpenter D, Wu B, Kuroda S, Ting K. Nell-1 induces acrania-like cranioskeletal deformities during mouse embryonic development. Lab Invest. 2006 Jul; 86(7):633-44. PMID: 16652108.
      View in: PubMed
    115. Cowan CM, Cheng S, Ting K, Soo C, Walder B, Wu B, Kuroda S, Zhang X. Nell-1 induced bone formation within the distracted intermaxillary suture. Bone. 2006 Jan; 38(1):48-58. PMID: 16243593.
      View in: PubMed
    116. Law CS, Warren SM, Mehrara BJ, Ting K. Gene expression profiling in the rat cranial suture. J Craniofac Surg. 2005 May; 16(3):378-88; discussion 389-90. PMID: 15915100.
      View in: PubMed
    117. Cowan CM, Soo C, Ting K, Wu B. Evolving concepts in bone tissue engineering. Curr Top Dev Biol. 2005; 66:239-85. PMID: 15797456.
      View in: PubMed
    118. Colwell AS, Beanes SR, Soo C, Dang C, Ting K, Longaker MT, Atkinson JB, Lorenz HP. Increased angiogenesis and expression of vascular endothelial growth factor during scarless repair. Plast Reconstr Surg. 2005 Jan; 115(1):204-12. PMID: 15622252.
      View in: PubMed
    119. Zhang X, Carpenter D, Bokui N, Soo C, Miao S, Truong T, Wu B, Chen I, Vastardis H, Tanizawa K, Kuroda S, Ting K. Overexpression of Nell-1, a craniosynostosis-associated gene, induces apoptosis in osteoblasts during craniofacial development. J Bone Miner Res. 2003 Dec; 18(12):2126-34. PMID: 14672347.
      View in: PubMed
    120. Soo C, Beanes SR, Hu FY, Zhang X, Dang C, Chang G, Wang Y, Nishimura I, Freymiller E, Longaker MT, Lorenz HP, Ting K. Ontogenetic transition in fetal wound transforming growth factor-beta regulation correlates with collagen organization. Am J Pathol. 2003 Dec; 163(6):2459-76. PMID: 14633618; PMCID: PMC1892380.
    121. Trahar M, Sheffield R, Kawamoto H, Lee HF, Ting K. Cephalometric evaluation of the craniofacial complex in patients treated with an intraoral distraction osteogenesis device: a preliminary report. Am J Orthod Dentofacial Orthop. 2003 Dec; 124(6):639-50. PMID: 14666076.
      View in: PubMed
    122. Dang CM, Beanes SR, Lee H, Zhang X, Soo C, Ting K. Scarless fetal wounds are associated with an increased matrix metalloproteinase-to-tissue-derived inhibitor of metalloproteinase ratio. Plast Reconstr Surg. 2003 Jun; 111(7):2273-85. PMID: 12794470.
      View in: PubMed
    123. Dang CM, Beanes SR, Soo C, Ting K, Benhaim P, Hedrick MH, Lorenz HP. Decreased expression of fibroblast and keratinocyte growth factor isoforms and receptors during scarless repair. Plast Reconstr Surg. 2003 May; 111(6):1969-79. PMID: 12711959.
      View in: PubMed
    124. Beanes SR, Dang C, Soo C, Ting K. Skin repair and scar formation: the central role of TGF-beta. Expert Rev Mol Med. 2003 Mar 21; 5(8):1-22. PMID: 14987411.
      View in: PubMed
    125. Dang C, Ting K, Soo C, Longaker MT, Lorenz HP. Fetal wound healing current perspectives. Clin Plast Surg. 2003 Jan; 30(1):13-23. PMID: 12636212.
      View in: PubMed
    126. Zhang X, Kuroda S, Carpenter D, Nishimura I, Soo C, Moats R, Iida K, Wisner E, Hu FY, Miao S, Beanes S, Dang C, Vastardis H, Longaker M, Tanizawa K, Kanayama N, Saito N, Ting K. Craniosynostosis in transgenic mice overexpressing Nell-1. J Clin Invest. 2002 Sep; 110(6):861-70. PMID: 12235118; PMCID: PMC151127.
    127. Soo C, Sayah DN, Zhang X, Beanes SR, Nishimura I, Dang C, Freymiller E, Ting K. The identification of novel wound-healing genes through differential display. Plast Reconstr Surg. 2002 Sep 01; 110(3):787-97; discussion 798-800. PMID: 12172140.
      View in: PubMed
    128. Beanes SR, Hu FY, Soo C, Dang CM, Urata M, Ting K, Atkinson JB, Benhaim P, Hedrick MH, Lorenz HP. Confocal microscopic analysis of scarless repair in the fetal rat: defining the transition. Plast Reconstr Surg. 2002 Jan; 109(1):160-70. PMID: 11786808.
      View in: PubMed