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Lyons Karen

Title(s)Professor, Molecular Cell and Developmental Biology
Phone(310) 825-5480
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    Title: BMP/TGFbeta crosstalk in cartilage maintenance and osteoarthritis
    NIH/NIAMS R01AR073793Jul 19, 2018 - Apr 30, 2023
    Role: Principal Investigator
    GP130/STAT3 signalling in articular cartilage development and regeneration
    NIH/NIAMS R01AR071734Apr 1, 2018 - Jan 31, 2023
    Role: Co-Principal Investigator
    Regulation of tendon development by CCN1/Cyr61
    NIH/NIAMS R21AR071728Mar 10, 2017 - Dec 31, 2019
    Role: Principal Investigator
    2011 Cartilage Biology &Pathology GRC
    NIH/NIAMS R13AR061167Mar 1, 2011 - Feb 29, 2012
    Role: Principal Investigator
    Regenerative Musculoskeletal Medicine Training Program
    NIH/NIAMS T32AR059033Apr 1, 2010 - Jul 31, 2021
    Role: Co-Principal Investigator
    CCN PROTEINS IN CARTILAGE FORMATION AND MAINTENANCE
    NIH/NIAMS R01AR052686Aug 20, 2005 - Jun 30, 2016
    Role: Principal Investigator
    BMP'S IN SKELETAL GROWTH AND OSTEOGENIC DIFFERENTIATION
    NIH/NIAMS R01AR044528Apr 1, 1998 - Mar 31, 2018
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Jaworek AJ, Earasi K, Lyons KM, Daggumati S, Hu A, Sataloff RT. Acute infectious laryngitis: A case series. Ear Nose Throat J. 2018 Sep; 97(9):306-313. PMID: 30273430.
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    2. Zhao G, Huang BL, Rigueur D, Wang W, Bhoot C, Charles KR, Baek J, Mohan S, Jiang J, Lyons KM. CYR61/CCN1 Regulates Sclerostin Levels and Bone Maintenance. J Bone Miner Res. 2018 Jun; 33(6):1076-1089. PMID: 29351359.
      View in: PubMed
    3. Jiang J, Zhao G, Lyons KM. Correction to: Characterization of bone morphology in CCN5/WISP2 knockout mice. J Cell Commun Signal. 2018 Mar; 12(1):271. PMID: 29455304.
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    4. Jiang J, Zhao G, Lyons KM. Characterization of bone morphology in CCN5/WISP5 knockout mice. J Cell Commun Signal. 2018 Mar; 12(1):265-270. PMID: 29396648.
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    5. Pan H, Zhang H, Abraham P, Komatsu Y, Lyons K, Kaartinen V, Mishina Y. BmpR1A is a major type 1 BMP receptor for BMP-Smad signaling during skull development. Dev Biol. 2017 09 01; 429(1):260-270. PMID: 28641928.
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    6. Burga A, Wang W, Ben-David E, Wolf PC, Ramey AM, Verdugo C, Lyons K, Parker PG, Kruglyak L. A genetic signature of the evolution of loss of flight in the Galapagos cormorant. Science. 2017 Jun 02; 356(6341). PMID: 28572335.
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    7. Zhang Y, Huang H, Zhao G, Yokoyama T, Vega H, Huang Y, Sood R, Bishop K, Maduro V, Accardi J, Toro C, Boerkoel CF, Lyons K, Gahl WA, Duan X, Malicdan MC, Lin S. Correction: ATP6V1H Deficiency Impairs Bone Development through Activation of MMP9 and MMP13. PLoS Genet. 2017 Feb; 13(2):e1006624. PMID: 28241013.
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    8. Zhang Y, Huang H, Zhao G, Yokoyama T, Vega H, Huang Y, Sood R, Bishop K, Maduro V, Accardi J, Toro C, Boerkoel CF, Lyons K, Gahl WA, Duan X, Malicdan MC, Lin S. ATP6V1H Deficiency Impairs Bone Development through Activation of MMP9 and MMP13. PLoS Genet. 2017 02; 13(2):e1006481. PMID: 28158191.
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    9. Jiang J, Hu Z, Lyons KM. Design and Analysis of CCN Gene Activity Using CCN Knockout Mice Containing LacZ Reporters. Methods Mol Biol. 2017; 1489:325-345. PMID: 27734387.
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    10. Falke LL, Leeuwis JW, Lyons KM, Mummery CL, Nguyen TQ, Goldschmeding R. CCN2 reduction mediates protective effects of BMP7 treatment in obstructive nephropathy. J Cell Commun Signal. 2017 Mar; 11(1):39-48. PMID: 27766493.
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    11. Wang W, Song B, Anbarchian T, Shirazyan A, Sadik JE, Lyons KM. Smad2 and Smad3 Regulate Chondrocyte Proliferation and Differentiation in the Growth Plate. PLoS Genet. 2016 Oct; 12(10):e1006352. PMID: 27741240.
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    12. Rojas Y, Jaramillo S, Lyons K, Mahmood N, Wu MF, Liu H, Vasudevan SA, Guillerman RP, Louis CU, Russell HV, Nuchtern JG, Kim ES. The optimal timing of surgical resection in high-risk neuroblastoma. J Pediatr Surg. 2016 Oct; 51(10):1665-9. PMID: 27318861.
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    13. Krishnamurthy R, Malone L, Lyons K, Ketwaroo P, Dodd N, Ashton D. Body MR angiography in children: how we do it. Pediatr Radiol. 2016 May; 46(6):748-63. PMID: 27229494.
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    14. Shi C, Iura A, Terajima M, Liu F, Lyons K, Pan H, Zhang H, Yamauchi M, Mishina Y, Sun H. Deletion of BMP receptor type IB decreased bone mass in association with compromised osteoblastic differentiation of bone marrow mesenchymal progenitors. Sci Rep. 2016 Apr 06; 6:24256. PMID: 27048979; PMCID: PMC4822175.
    15. Zieba J, Forlenza KN, Khatra JS, Sarukhanov A, Duran I, Rigueur D, Lyons KM, Cohn DH, Merrill AE, Krakow D. TGFß and BMP Dependent Cell Fate Changes Due to Loss of Filamin B Produces Disc Degeneration and Progressive Vertebral Fusions. PLoS Genet. 2016 Mar; 12(3):e1005936. PMID: 27019229; PMCID: PMC4809497.
    16. Perbal B, Lau L, Lyons K, Kubota S, Yeger H, Fisher G. Report on the 8th international workshop on the CCN family of genes - Nice November 3-8, 2015. J Cell Commun Signal. 2016 Mar; 10(1):77-86. PMID: 26920000; PMCID: PMC4850142.
    17. Lyons K, Seghers V, Sorensen JI, Zhang W, Paldino MJ, Krishnamurthy R, Rohren EM. Comparison of Standardized Uptake Values in Normal Structures Between PET/CT and PET/MRI in a Tertiary Pediatric Hospital: A Prospective Study. AJR Am J Roentgenol. 2015 Nov; 205(5):1094-101. PMID: 26496558.
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    18. Murase Y, Hattori T, Aoyama E, Nishida T, Maeda-Uematsu A, Kawaki H, Lyons KM, Sasaki A, Takigawa M, Kubota S. Role of CCN2 in Amino Acid Metabolism of Chondrocytes. J Cell Biochem. 2016 Apr; 117(4):927-37. PMID: 26364758.
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    19. Mangiavini L, Merceron C, Araldi E, Khatri R, Gerard-O'Riley R, Wilson TL, Sandusky G, Abadie J, Lyons KM, Giaccia AJ, Schipani E. Fibrosis and hypoxia-inducible factor-1a-dependent tumors of the soft tissue on loss of von Hippel-Lindau in mesenchymal progenitors. Am J Pathol. 2015 Nov; 185(11):3090-101. PMID: 26348575.
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    20. Lyons K, Seghers V, Williams JL, Sorensen JI, Paldino MJ, Krishnamurthy R, Rohren EM. Qualitative FDG PET Image Assessment Using Automated Three-Segment MR Attenuation Correction Versus CT Attenuation Correction in a Tertiary Pediatric Hospital: A Prospective Study. AJR Am J Roentgenol. 2015 Sep; 205(3):652-8. PMID: 26295654.
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    21. James AW, Shen J, Zhang X, Asatrian G, Goyal R, Kwak JH, Jiang L, Bengs B, Culiat CT, Turner AS, Seim Iii HB, Wu BM, Lyons K, Adams JS, Ting K, Soo C. NELL-1 in the treatment of osteoporotic bone loss. Nat Commun. 2015 Jun 17; 6:7362. PMID: 26082355; PMCID: PMC4557288.
    22. Lyons K, Cassady C, Mehollin-Ray A, Krishnamurthy R. Current Role of Fetal Magnetic Resonance Imaging in Body Anomalies. Semin Ultrasound CT MR. 2015 Aug; 36(4):310-23. PMID: 26296482.
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    23. Lyons K, Cassady C, Jones J, Paldino M, Mehollin-Ray A, Guimaraes C, Krishnamurthy R. Current Role of Fetal Magnetic Resonance Imaging in Neurologic Anomalies. Semin Ultrasound CT MR. 2015 Aug; 36(4):298-309. PMID: 26296481.
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    24. Maeda A, Ono M, Holmbeck K, Li L, Kilts TM, Kram V, Noonan ML, Yoshioka Y, McNerny EM, Tantillo MA, Kohn DH, Lyons KM, Robey PG, Young MF. WNT1-induced Secreted Protein-1 (WISP1), a Novel Regulator of Bone Turnover and Wnt Signaling. J Biol Chem. 2015 May 29; 290(22):14004-18. PMID: 25864198; PMCID: PMC4447973.
    25. Rigueur D, Brugger S, Anbarchian T, Kim JK, Lee Y, Lyons KM. The type I BMP receptor ACVR1/ALK2 is required for chondrogenesis during development. J Bone Miner Res. 2015 Apr; 30(4):733-41. PMID: 25413979; PMCID: PMC4376569.
    26. Briot A, Jaroszewicz A, Warren CM, Lu J, Touma M, Rudat C, Hofmann JJ, Airik R, Weinmaster G, Lyons K, Wang Y, Kispert A, Pellegrini M, Iruela-Arispe ML. Repression of Sox9 by Jag1 is continuously required to suppress the default chondrogenic fate of vascular smooth muscle cells. Dev Cell. 2014 Dec 22; 31(6):707-21. PMID: 25535917; PMCID: PMC4311887.
    27. Güemes M, Garcia AJ, Rigueur D, Runke S, Wang W, Zhao G, Mayorga VH, Atti E, Tetradis S, Péault B, Lyons K, Miranda-Carboni GA, Krum SA. GATA4 is essential for bone mineralization via ERa and TGFß/BMP pathways. J Bone Miner Res. 2014 Dec; 29(12):2676-87. PMID: 24932701; PMCID: PMC4501475.
    28. Ascenzi M, Du X, Harding JI, Beylerian EN, de Silva BM, Gross BJ, Kastein HK, Wang W, Lyons KM, Schaeffer H. Automated Cell Detection and Morphometry on Growth Plate Images of Mouse Bone. Appl Math (Irvine). 2014 Oct; 5(18):2866-2880. PMID: 25525552.
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    29. Nishida T, Kubota S, Aoyama E, Janune D, Lyons KM, Takigawa M. CCN family protein 2 (CCN2) promotes the early differentiation, but inhibits the terminal differentiation of skeletal myoblasts. J Biochem. 2015 Feb; 157(2):91-100. PMID: 25261584.
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    30. Heman-Ackah YD, Sataloff RT, Laureyns G, Lurie D, Michael DD, Heuer R, Rubin A, Eller R, Chandran S, Abaza M, Lyons K, Divi V, Lott J, Johnson J, Hillenbrand J. Quantifying the cepstral peak prominence, a measure of dysphonia. J Voice. 2014 Nov; 28(6):783-8. PMID: 25179777.
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    31. Maeda-Uematsu A, Kubota S, Kawaki H, Kawata K, Miyake Y, Hattori T, Nishida T, Moritani N, Lyons KM, Iida S, Takigawa M. CCN2 as a novel molecule supporting energy metabolism of chondrocytes. J Cell Biochem. 2014 May; 115(5):854-65. PMID: 24288211; PMCID: PMC4267909.
    32. Cheung LC, Strickland DH, Howlett M, Ford J, Charles AK, Lyons KM, Brigstock DR, Goldschmeding R, Cole CH, Alexander WS, Kees UR. Connective tissue growth factor is expressed in bone marrow stromal cells and promotes interleukin-7-dependent B lymphopoiesis. Haematologica. 2014 Jul; 99(7):1149-56. PMID: 24727816; PMCID: PMC4077075.
    33. Wang W, Rigueur D, Lyons KM. TGFß signaling in cartilage development and maintenance. Birth Defects Res C Embryo Today. 2014 Mar; 102(1):37-51. PMID: 24677722; PMCID: PMC4267887.
    34. Rigueur D, Lyons KM. Whole-mount skeletal staining. Methods Mol Biol. 2014; 1130:113-121. PMID: 24482169.
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    35. Wu L, Bluguermann C, Kyupelyan L, Latour B, Gonzalez S, Shah S, Galic Z, Ge S, Zhu Y, Petrigliano FA, Nsair A, Miriuka SG, Li X, Lyons KM, Crooks GM, McAllister DR, Van Handel B, Adams JS, Evseenko D. Human developmental chondrogenesis as a basis for engineering chondrocytes from pluripotent stem cells. Stem Cell Reports. 2013; 1(6):575-89. PMID: 24371811; PMCID: PMC3871393.
    36. Estrada KD, Wang W, Retting KN, Chien CT, Elkhoury FF, Heuchel R, Lyons KM. Smad7 regulates terminal maturation of chondrocytes in the growth plate. Dev Biol. 2013 Oct 15; 382(2):375-84. PMID: 23994637; PMCID: PMC4267888.
    37. Battula VL, Chen Y, Cabreira Mda G, Ruvolo V, Wang Z, Ma W, Konoplev S, Shpall E, Lyons K, Strunk D, Bueso-Ramos C, Davis RE, Konopleva M, Andreeff M. Connective tissue growth factor regulates adipocyte differentiation of mesenchymal stromal cells and facilitates leukemia bone marrow engraftment. Blood. 2013 Jul 18; 122(3):357-66. PMID: 23741006; PMCID: PMC3716201.
    38. Hall-Glenn F, Aivazi A, Akopyan L, Ong JR, Baxter RR, Benya PD, Goldschmeding R, van Nieuwenhoven FA, Hunziker EB, Lyons KM. CCN2/CTGF is required for matrix organization and to protect growth plate chondrocytes from cellular stress. J Cell Commun Signal. 2013 Aug; 7(3):219-30. PMID: 23666466; PMCID: PMC3709047.
    39. Tran CM, Fujita N, Huang BL, Ong JR, Lyons KM, Shapiro IM, Risbud MV. Hypoxia-inducible factor (HIF)-1a and CCN2 form a regulatory circuit in hypoxic nucleus pulposus cells: CCN2 suppresses HIF-1a level and transcriptional activity. J Biol Chem. 2013 May 03; 288(18):12654-66. PMID: 23530034; PMCID: PMC3642312.
    40. Falke LL, Dendooven A, Leeuwis JW, Nguyen TQ, van Geest RJ, van der Giezen DM, Broekhuizen R, Lyons K, Stoop R, Kemperman H, Schlingemann R, Joles JA, Goldschmeding R. Hemizygous deletion of CTGF/CCN2 does not suffice to prevent fibrosis of the severely injured kidney. Matrix Biol. 2012 Sep-Oct; 31(7-8):421-31. PMID: 23199377.
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    41. Merrill AE, Sarukhanov A, Krejci P, Idoni B, Camacho N, Estrada KD, Lyons KM, Deixler H, Robinson H, Chitayat D, Curry CJ, Lachman RS, Wilcox WR, Krakow D. Bent bone dysplasia-FGFR2 type, a distinct skeletal disorder, has deficient canonical FGF signaling. Am J Hum Genet. 2012 Mar 09; 90(3):550-7. PMID: 22387015; PMCID: PMC3309195.
    42. Hall-Glenn F, De Young RA, Huang BL, van Handel B, Hofmann JJ, Chen TT, Choi A, Ong JR, Benya PD, Mikkola H, Iruela-Arispe ML, Lyons KM. CCN2/connective tissue growth factor is essential for pericyte adhesion and endothelial basement membrane formation during angiogenesis. PLoS One. 2012; 7(2):e30562. PMID: 22363445; PMCID: PMC3282727.
    43. Heman-Ackah YD, Hawkshaw MJ, Lyons KM. Laryngeal thrush from asthma inhalers. Ear Nose Throat J. 2012 Jan; 91(1):E24-5. PMID: 22278875.
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    44. Estrada KD, Retting KN, Chin AM, Lyons KM. Smad6 is essential to limit BMP signaling during cartilage development. J Bone Miner Res. 2011 Oct; 26(10):2498-510. PMID: 21681813; PMCID: PMC3183270.
    45. Nagashima T, Kim J, Li Q, Lydon JP, DeMayo FJ, Lyons KM, Matzuk MM. Connective tissue growth factor is required for normal follicle development and ovulation. Mol Endocrinol. 2011 Oct; 25(10):1740-59. PMID: 21868453; PMCID: PMC3182424.
    46. Hall-Glenn F, Lyons KM. Roles for CCN2 in normal physiological processes. Cell Mol Life Sci. 2011 Oct; 68(19):3209-17. PMID: 21858450; PMCID: PMC3670951.
    47. Ascenzi MG, Blanco C, Drayer I, Kim H, Wilson R, Retting KN, Lyons KM, Mohler G. Effect of localization, length and orientation of chondrocytic primary cilium on murine growth plate organization. J Theor Biol. 2011 Sep 21; 285(1):147-55. PMID: 21723296; PMCID: PMC3163056.
    48. Suwanwela J, Farber CR, Haung BL, Song B, Pan C, Lyons KM, Lusis AJ. Systems genetics analysis of mouse chondrocyte differentiation. J Bone Miner Res. 2011 Apr; 26(4):747-60. PMID: 20954177; PMCID: PMC3179327.
    49. Chien W, O'Kelly J, Lu D, Leiter A, Sohn J, Yin D, Karlan B, Vadgama J, Lyons KM, Koeffler HP. Expression of connective tissue growth factor (CTGF/CCN2) in breast cancer cells is associated with increased migration and angiogenesis. Int J Oncol. 2011 Jun; 38(6):1741-7. PMID: 21455569; PMCID: PMC3711677.
    50. Nishida T, Emura K, Kubota S, Lyons KM, Takigawa M. CCN family 2/connective tissue growth factor (CCN2/CTGF) promotes osteoclastogenesis via induction of and interaction with dendritic cell-specific transmembrane protein (DC-STAMP). J Bone Miner Res. 2011 Feb; 26(2):351-63. PMID: 20721934; PMCID: PMC3836692.
    51. Ohyama T, Basch ML, Mishina Y, Lyons KM, Segil N, Groves AK. BMP signaling is necessary for patterning the sensory and nonsensory regions of the developing mammalian cochlea. J Neurosci. 2010 Nov 10; 30(45):15044-51. PMID: 21068310; PMCID: PMC3074492.
    52. Stevens JR, Miranda-Carboni GA, Singer MA, Brugger SM, Lyons KM, Lane TF. Wnt10b deficiency results in age-dependent loss of bone mass and progressive reduction of mesenchymal progenitor cells. J Bone Miner Res. 2010 Oct; 25(10):2138-47. PMID: 20499361; PMCID: PMC3153316.
    53. Huang BL, Brugger SM, Lyons KM. Stage-specific control of connective tissue growth factor (CTGF/CCN2) expression in chondrocytes by Sox9 and beta-catenin. J Biol Chem. 2010 Sep 03; 285(36):27702-12. PMID: 20571031; PMCID: PMC2934638.
    54. Edson MA, Nalam RL, Clementi C, Franco HL, Demayo FJ, Lyons KM, Pangas SA, Matzuk MM. Granulosa cell-expressed BMPR1A and BMPR1B have unique functions in regulating fertility but act redundantly to suppress ovarian tumor development. Mol Endocrinol. 2010 Jun; 24(6):1251-66. PMID: 20363875; PMCID: PMC2875809.
    55. Song B, Estrada KD, Lyons KM. Smad signaling in skeletal development and regeneration. Cytokine Growth Factor Rev. 2009 Oct-Dec; 20(5-6):379-88. PMID: 19926329; PMCID: PMC2825570.
    56. Chandran SK, Lyons KM, Divi V, Geyer M, Sataloff RT. Fungal laryngitis. Ear Nose Throat J. 2009 Aug; 88(8):1026-7. PMID: 19688709.
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    57. Lyons K, Ezaki M. Molecular regulation of limb growth. J Bone Joint Surg Am. 2009 Jul; 91 Suppl 4:47-52. PMID: 19571067; PMCID: PMC2698795.
    58. Turk T, Leeuwis JW, Gray J, Torti SV, Lyons KM, Nguyen TQ, Goldschmeding R. BMP signaling and podocyte markers are decreased in human diabetic nephropathy in association with CTGF overexpression. J Histochem Cytochem. 2009 Jul; 57(7):623-31. PMID: 19255250; PMCID: PMC2699318.
    59. Retting KN, Song B, Yoon BS, Lyons KM. BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation. Development. 2009 Apr; 136(7):1093-104. PMID: 19224984; PMCID: PMC2668702.
    60. Eller R, Ginsburg M, Lurie D, Heman-Ackah Y, Lyons K, Sataloff R. Flexible laryngoscopy: a comparison of fiber optic and distal chip technologies-part 2: laryngopharyngeal reflux. J Voice. 2009 May; 23(3):389-95. PMID: 19185459.
      View in: PubMed
    61. Crawford LA, Guney MA, Oh YA, Deyoung RA, Valenzuela DM, Murphy AJ, Yancopoulos GD, Lyons KM, Brigstock DR, Economides A, Gannon M. Connective tissue growth factor (CTGF) inactivation leads to defects in islet cell lineage allocation and beta-cell proliferation during embryogenesis. Mol Endocrinol. 2009 Mar; 23(3):324-36. PMID: 19131512; PMCID: PMC2654514.
    62. Maeda A, Nishida T, Aoyama E, Kubota S, Lyons KM, Kuboki T, Takigawa M. CCN family 2/connective tissue growth factor modulates BMP signalling as a signal conductor, which action regulates the proliferation and differentiation of chondrocytes. J Biochem. 2009 Feb; 145(2):207-16. PMID: 19038999; PMCID: PMC2760593.
    63. Kawaki H, Kubota S, Suzuki A, Lazar N, Yamada T, Matsumura T, Ohgawara T, Maeda T, Perbal B, Lyons KM, Takigawa M. Cooperative regulation of chondrocyte differentiation by CCN2 and CCN3 shown by a comprehensive analysis of the CCN family proteins in cartilage. J Bone Miner Res. 2008 Nov; 23(11):1751-64. PMID: 18597638.
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    64. Nishida T, Kondo S, Maeda A, Kubota S, Lyons KM, Takigawa M. CCN family 2/connective tissue growth factor (CCN2/CTGF) regulates the expression of Vegf through Hif-1alpha expression in a chondrocytic cell line, HCS-2/8, under hypoxic condition. Bone. 2009 Jan; 44(1):24-31. PMID: 18835464; PMCID: PMC2760594.
    65. Nguyen TQ, Roestenberg P, van Nieuwenhoven FA, Bovenschen N, Li Z, Xu L, Oliver N, Aten J, Joles JA, Vial C, Brandan E, Lyons KM, Goldschmeding R. CTGF inhibits BMP-7 signaling in diabetic nephropathy. J Am Soc Nephrol. 2008 Nov; 19(11):2098-107. PMID: 18632843; PMCID: PMC2573007.
    66. Sengle G, Ono RN, Lyons KM, Bächinger HP, Sakai LY. A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7. J Mol Biol. 2008 Sep 12; 381(4):1025-39. PMID: 18621057; PMCID: PMC2705212.
    67. Kuiper EJ, van Zijderveld R, Roestenberg P, Lyons KM, Goldschmeding R, Klaassen I, Van Noorden CJ, Schlingemann RO. Connective tissue growth factor is necessary for retinal capillary basal lamina thickening in diabetic mice. J Histochem Cytochem. 2008 Aug; 56(8):785-92. PMID: 18474939; PMCID: PMC2443606.
    68. Pala D, Kapoor M, Woods A, Kennedy L, Liu S, Chen S, Bursell L, Lyons KM, Carter DE, Beier F, Leask A. Focal adhesion kinase/Src suppresses early chondrogenesis: central role of CCN2. J Biol Chem. 2008 Apr 04; 283(14):9239-47. PMID: 18276598; PMCID: PMC2431031.
    69. Einhorn TA, Laurencin CT, Lyons K. An AAOS-NIH symposium. Fracture repair: challenges, opportunities, and directions for future research. J Bone Joint Surg Am. 2008 Feb; 90(2):438-42. PMID: 18245605.
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    70. Laurencin CT, Einhorn TA, Lyons K. Fracture repair: challenges and opportunities. J Bone Joint Surg Am. 2008 Feb; 90 Suppl 1:1-2. PMID: 18292348.
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    71. Eller R, Ginsburg M, Lurie D, Heman-Ackah Y, Lyons K, Sataloff R. Flexible laryngoscopy: a comparison of fiber optic and distal chip technologies. Part 1: vocal fold masses. J Voice. 2008 Nov; 22(6):746-50. PMID: 18207364.
      View in: PubMed
    72. Pacheco MS, Reis AH, Aguiar DP, Lyons KM, Abreu JG. Dynamic analysis of the expression of the TGFbeta/SMAD2 pathway and CCN2/CTGF during early steps of tooth development. Cells Tissues Organs. 2008; 187(3):199-210. PMID: 18089935; PMCID: PMC2760595.
    73. Kawaki H, Kubota S, Suzuki A, Yamada T, Matsumura T, Mandai T, Yao M, Maeda T, Lyons KM, Takigawa M. Functional requirement of CCN2 for intramembranous bone formation in embryonic mice. Biochem Biophys Res Commun. 2008 Feb 08; 366(2):450-6. PMID: 18067859; PMCID: PMC2760596.
    74. Kuiper EJ, Roestenberg P, Ehlken C, Lambert V, van Treslong-de Groot HB, Lyons KM, Agostini HJ, Rakic JM, Klaassen I, Van Noorden CJ, Goldschmeding R, Schlingemann RO. Angiogenesis is not impaired in connective tissue growth factor (CTGF) knock-out mice. J Histochem Cytochem. 2007 Nov; 55(11):1139-47. PMID: 17625227; PMCID: PMC3957533.
    75. Nishida T, Kawaki H, Baxter RM, Deyoung RA, Takigawa M, Lyons KM. CCN2 (Connective Tissue Growth Factor) is essential for extracellular matrix production and integrin signaling in chondrocytes. J Cell Commun Signal. 2007 Jun; 1(1):45-58. PMID: 18481209; PMCID: PMC2267656.
    76. Huang BL, Dornbach LM, Lyons KM. The 5' untranslated regions (UTRs) of CCN1, CCN2, and CCN4 exhibit cryptic promoter activity. J Cell Commun Signal. 2007 Jun; 1(1):17-32. PMID: 18481207; PMCID: PMC2267653.
    77. Kennedy L, Liu S, Shi-Wen X, Chen Y, Eastwood M, Sabetkar M, Carter DE, Lyons KM, Black CM, Abraham DJ, Leask A. CCN2 is necessary for the function of mouse embryonic fibroblasts. Exp Cell Res. 2007 Mar 10; 313(5):952-64. PMID: 17239853.
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    78. Yoon BS, Pogue R, Ovchinnikov DA, Yoshii I, Mishina Y, Behringer RR, Lyons KM. BMPs regulate multiple aspects of growth-plate chondrogenesis through opposing actions on FGF pathways. Development. 2006 Dec; 133(23):4667-78. PMID: 17065231.
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    79. Gamradt SC, Abe N, Bahamonde ME, Lee YP, Nelson SD, Lyons KM, Lieberman JR. Tracking expression of virally mediated BMP-2 in gene therapy for bone repair. Clin Orthop Relat Res. 2006 Sep; 450:238-45. PMID: 16702923; PMCID: PMC4291079.
    80. Wan DC, Shi YY, Nacamuli RP, Quarto N, Lyons KM, Longaker MT. Osteogenic differentiation of mouse adipose-derived adult stromal cells requires retinoic acid and bone morphogenetic protein receptor type IB signaling. Proc Natl Acad Sci U S A. 2006 Aug 15; 103(33):12335-40. PMID: 16894153; PMCID: PMC1567881.
    81. Merrill AE, Bochukova EG, Brugger SM, Ishii M, Pilz DT, Wall SA, Lyons KM, Wilkie AO, Maxson RE. Cell mixing at a neural crest-mesoderm boundary and deficient ephrin-Eph signaling in the pathogenesis of craniosynostosis. Hum Mol Genet. 2006 Apr 15; 15(8):1319-28. PMID: 16540516.
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    82. Shi-wen X, Stanton LA, Kennedy L, Pala D, Chen Y, Howat SL, Renzoni EA, Carter DE, Bou-Gharios G, Stratton RJ, Pearson JD, Beier F, Lyons KM, Black CM, Abraham DJ, Leask A. CCN2 is necessary for adhesive responses to transforming growth factor-beta1 in embryonic fibroblasts. J Biol Chem. 2006 Apr 21; 281(16):10715-26. PMID: 16484225.
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    83. Pogue R, Lyons K. BMP signaling in the cartilage growth plate. Curr Top Dev Biol. 2006; 76:1-48. PMID: 17118262.
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    84. Kobayashi T, Lyons KM, McMahon AP, Kronenberg HM. BMP signaling stimulates cellular differentiation at multiple steps during cartilage development. Proc Natl Acad Sci U S A. 2005 Dec 13; 102(50):18023-7. PMID: 16322106; PMCID: PMC1312369.
    85. Lee NV, Rodriguez-Manzaneque JC, Thai SN, Twal WO, Luque A, Lyons KM, Argraves WS, Iruela-Arispe ML. Fibulin-1 acts as a cofactor for the matrix metalloprotease ADAMTS-1. J Biol Chem. 2005 Oct 14; 280(41):34796-804. PMID: 16061471.
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    86. Kim J, Wu HH, Lander AD, Lyons KM, Matzuk MM, Calof AL. GDF11 controls the timing of progenitor cell competence in developing retina. Science. 2005 Jun 24; 308(5730):1927-30. PMID: 15976303.
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    87. Zakin L, Reversade B, Kuroda H, Lyons KM, De Robertis EM. Sirenomelia in Bmp7 and Tsg compound mutant mice: requirement for Bmp signaling in the development of ventral posterior mesoderm. Development. 2005 May; 132(10):2489-99. PMID: 15843411.
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    88. Yoon BS, Ovchinnikov DA, Yoshii I, Mishina Y, Behringer RR, Lyons KM. Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo. Proc Natl Acad Sci U S A. 2005 Apr 05; 102(14):5062-7. PMID: 15781876; PMCID: PMC555995.
    89. Murali D, Yoshikawa S, Corrigan RR, Plas DJ, Crair MC, Oliver G, Lyons KM, Mishina Y, Furuta Y. Distinct developmental programs require different levels of Bmp signaling during mouse retinal development. Development. 2005 Mar; 132(5):913-23. PMID: 15673568.
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    90. Chuva de Sousa Lopes SM, Feijen A, Korving J, Korchynskyi O, Larsson J, Karlsson S, ten Dijke P, Lyons KM, Goldschmeding R, Doevendans P, Mummery CL. Connective tissue growth factor expression and Smad signaling during mouse heart development and myocardial infarction. Dev Dyn. 2004 Nov; 231(3):542-50. PMID: 15376321.
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    91. Wine-Lee L, Ahn KJ, Richardson RD, Mishina Y, Lyons KM, Crenshaw EB. Signaling through BMP type 1 receptors is required for development of interneuron cell types in the dorsal spinal cord. Development. 2004 Nov; 131(21):5393-403. PMID: 15469980.
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    92. Brugger SM, Merrill AE, Torres-Vazquez J, Wu N, Ting MC, Cho JY, Dobias SL, Yi SE, Lyons K, Bell JR, Arora K, Warrior R, Maxson R. A phylogenetically conserved cis-regulatory module in the Msx2 promoter is sufficient for BMP-dependent transcription in murine and Drosophila embryos. Development. 2004 Oct; 131(20):5153-65. PMID: 15459107.
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    93. Chen Y, Abraham DJ, Shi-Wen X, Pearson JD, Black CM, Lyons KM, Leask A. CCN2 (connective tissue growth factor) promotes fibroblast adhesion to fibronectin. Mol Biol Cell. 2004 Dec; 15(12):5635-46. PMID: 15371538.
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    94. Yoon BS, Lyons KM. Multiple functions of BMPs in chondrogenesis. J Cell Biochem. 2004 Sep 01; 93(1):93-103. PMID: 15352166.
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    95. Nakamura K, Kennedy MA, Baldán A, Bojanic DD, Lyons K, Edwards PA. Expression and regulation of multiple murine ATP-binding cassette transporter G1 mRNAs/isoforms that stimulate cellular cholesterol efflux to high density lipoprotein. J Biol Chem. 2004 Oct 29; 279(44):45980-9. PMID: 15319426.
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    96. Andl T, Ahn K, Kairo A, Chu EY, Wine-Lee L, Reddy ST, Croft NJ, Cebra-Thomas JA, Metzger D, Chambon P, Lyons KM, Mishina Y, Seykora JT, Crenshaw EB, Millar SE. Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development. Development. 2004 May; 131(10):2257-68. PMID: 15102710.
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    97. Ivkovic S, Yoon BS, Popoff SN, Safadi FF, Libuda DE, Stephenson RC, Daluiski A, Lyons KM. Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development. Development. 2003 Jun; 130(12):2779-91. PMID: 12736220; PMCID: PMC3360973.
    98. Schneider MD, Gaussin V, Lyons KM. Tempting fate: BMP signals for cardiac morphogenesis. Cytokine Growth Factor Rev. 2003 Feb; 14(1):1-4. PMID: 12485614.
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    99. Wu HH, Ivkovic S, Murray RC, Jaramillo S, Lyons KM, Johnson JE, Calof AL. Autoregulation of neurogenesis by GDF11. Neuron. 2003 Jan 23; 37(2):197-207. PMID: 12546816.
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    100. Nishimura I, Drake TA, Lusis AJ, Lyons KM, Nadeau JH, Zernik J. ENU large-scale mutagenesis and quantitative trait linkage (QTL) analysis in mice: novel technologies for searching polygenetic determinants of craniofacial abnormalities. Crit Rev Oral Biol Med. 2003; 14(5):320-30. PMID: 14530301.
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    101. Délot EC, Bahamonde ME, Zhao M, Lyons KM. BMP signaling is required for septation of the outflow tract of the mammalian heart. Development. 2003 Jan; 130(1):209-20. PMID: 12441304.
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