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Martin Kelsey

Title(s)Professor, Biological Chemistry
Phone(310)794-9507
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    Other Positions
    Title(s)Professor, Psychiatry and Biobehavioral Sciences


    Collapse Research 
    Collapse Research Activities and Funding
    Catecholaminergic Regulation of Transcription during Long-Lasting Hippocampal Plasticity
    NIH/NIMH R21MH113102Jun 1, 2018 - Apr 30, 2020
    Role: Principal Investigator
    Cytoplasmic Functions of Rbfox1, a Candidate Autism Gene
    NIH/NIMH R21MH101684Aug 1, 2013 - Jul 31, 2015
    Role: Principal Investigator
    Synapse to Nuclear Signaling During Long-Lasting Neuronal Plasticity
    NIH/NIMH R01MH077022Jul 5, 2007 - Mar 31, 2018
    Role: Principal Investigator
    Developing RNA Interference for Gene Specific Silencing in Aplysia Neurons
    NIH/NIMH R21MH077921Apr 1, 2007 - Mar 31, 2010
    Role: Principal Investigator
    Synapse to Nuclear Signaling During Long-Lasting Neuronal Plasticity
    NIH/NIMH R56MH077022Apr 1, 2006 - Jul 31, 2014
    Role: Principal Investigator
    The Ubiquitin Proteasome Pathway &Synaptic Plasticity
    NIH/NIMH R21MH069645Dec 1, 2003 - Nov 30, 2006
    Role: Principal Investigator
    Localized mRNAs in Synaptic Plasticity
    NIH/NINDS R01NS045324Sep 30, 1999 - Jun 30, 2014
    Role: Principal Investigator
    CDNA LIBRARIES PREPARED FROM PURE NEURONAL PROCESSES
    NIH/NIAAA R01AA012716Sep 30, 1999 - Aug 31, 2003
    Role: Principal Investigator
    Medical Scientist Training Program
    NIH/NIGMS T32GM008042Jul 1, 1983 - Jun 30, 2024
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Holt CE, Martin KC, Schuman EM. Local translation in neurons: visualization and function. Nat Struct Mol Biol. 2019 Jul; 26(7):557-566. PMID: 31270476.
      View in: PubMed
    2. Merkurjev D, Hong WT, Iida K, Oomoto I, Goldie BJ, Yamaguti H, Ohara T, Kawaguchi SY, Hirano T, Martin KC, Pellegrini M, Wang DO. Author Correction: Synaptic N6-methyladenosine (m6A) epitranscriptome reveals functional partitioning of localized transcripts. Nat Neurosci. 2018 Oct; 21(10):1493. PMID: 30097659.
      View in: PubMed
    3. Merkurjev D, Hong WT, Iida K, Oomoto I, Goldie BJ, Yamaguti H, Ohara T, Kawaguchi SY, Hirano T, Martin KC, Pellegrini M, Wang DO. Synaptic N6-methyladenosine (m6A) epitranscriptome reveals functional partitioning of localized transcripts. Nat Neurosci. 2018 Jul; 21(7):1004-1014. PMID: 29950670.
      View in: PubMed
    4. Vuong CK, Wei W, Lee JA, Lin CH, Damianov A, de la Torre-Ubieta L, Halabi R, Otis KO, Martin KC, O'Dell TJ, Black DL. Rbfox1 Regulates Synaptic Transmission through the Inhibitory Neuron-Specific vSNARE Vamp1. Neuron. 2018 Apr 04; 98(1):127-141.e7. PMID: 29621484.
      View in: PubMed
    5. Octeau JC, Chai H, Jiang R, Bonanno SL, Martin KC, Khakh BS. An Optical Neuron-Astrocyte Proximity Assay at Synaptic Distance Scales. Neuron. 2018 Apr 04; 98(1):49-66.e9. PMID: 29621490.
      View in: PubMed
    6. Van Driesche SJ, Martin KC. New frontiers in RNA transport and local translation in neurons. Dev Neurobiol. 2018 03; 78(3):331-339. PMID: 29314718.
      View in: PubMed
    7. Fontes MM, Guvenek A, Kawaguchi R, Zheng D, Huang A, Ho VM, Chen PB, Liu X, O'Dell TJ, Coppola G, Tian B, Martin KC. Activity-Dependent Regulation of Alternative Cleavage and Polyadenylation During Hippocampal Long-Term Potentiation. Sci Rep. 2017 Dec 12; 7(1):17377. PMID: 29234016.
      View in: PubMed
    8. Gao J, Marosi M, Choi J, Achiro JM, Kim S, Li S, Otis K, Martin KC, Portera-Cailliau C, Tontonoz P. The E3 ubiquitin ligase IDOL regulates synaptic ApoER2 levels and is important for plasticity and learning. Elife. 2017 09 11; 6. PMID: 28891791.
      View in: PubMed
    9. Herbst WA, Martin KC. Regulated transport of signaling proteins from synapse to nucleus. Curr Opin Neurobiol. 2017 08; 45:78-84. PMID: 28502891.
      View in: PubMed
    10. Chen PB, Kawaguchi R, Blum C, Achiro JM, Coppola G, O'Dell TJ, Martin KC. Mapping Gene Expression in Excitatory Neurons during Hippocampal Late-Phase Long-Term Potentiation. Front Mol Neurosci. 2017; 10:39. PMID: 28275336.
      View in: PubMed
    11. Martin KC. Tips for Young Scientists on the Junior Faculty/Independent Investigator Job Search. Neuron. 2017 Feb 22; 93(4):731-736. PMID: 28231461.
      View in: PubMed
    12. Poo MM, Pignatelli M, Ryan TJ, Tonegawa S, Bonhoeffer T, Martin KC, Rudenko A, Tsai LH, Tsien RW, Fishell G, Mullins C, Gonçalves JT, Shtrahman M, Johnston ST, Gage FH, Dan Y, Long J, Buzsáki G, Stevens C. What is memory? The present state of the engram. BMC Biol. 2016 05 19; 14:40. PMID: 27197636.
      View in: PubMed
    13. Damianov A, Ying Y, Lin CH, Lee JA, Tran D, Vashisht AA, Bahrami-Samani E, Xing Y, Martin KC, Wohlschlegel JA, Black DL. Rbfox Proteins Regulate Splicing as Part of a Large Multiprotein Complex LASR. Cell. 2016 Apr 21; 165(3):606-19. PMID: 27104978; PMCID: PMC4841943 [Available on 04/21/17].
    14. Martin KC, Schuman EM. NEUROSCIENCE. Opting in or out of the network. Science. 2015 Dec 18; 350(6267):1477-8. PMID: 26680183; PMCID: PMC4880026.
    15. Lee JA, Damianov A, Lin CH, Fontes M, Parikshak NN, Anderson ES, Geschwind DH, Black DL, Martin KC. Cytoplasmic Rbfox1 Regulates the Expression of Synaptic and Autism-Related Genes. Neuron. 2016 Jan 06; 89(1):113-28. PMID: 26687839; PMCID: PMC4858412 [Available on 01/06/17].
    16. Ch'ng TH, DeSalvo M, Lin P, Vashisht A, Wohlschlegel JA, Martin KC. Cell biological mechanisms of activity-dependent synapse to nucleus translocation of CRTC1 in neurons. Front Mol Neurosci. 2015; 8:48. PMID: 26388727.
      View in: PubMed
    17. Kim S, Martin KC. Neuron-wide RNA transport combines with netrin-mediated local translation to spatially regulate the synaptic proteome. Elife. 2015 Jan 08; 4. PMID: 25569157; PMCID: PMC4337609.
    18. Ho VM, Dallalzadeh LO, Karathanasis N, Keles MF, Vangala S, Grogan T, Poirazi P, Martin KC. GluA2 mRNA distribution and regulation by miR-124 in hippocampal neurons. Mol Cell Neurosci. 2014 Jul; 61:1-12. PMID: 24784359; PMCID: PMC4134974.
    19. Ch'ng TH, Uzgil B, Lin P, Avliyakulov NK, O'Dell TJ, Martin KC. Activity-dependent transport of the transcriptional coactivator CRTC1 from synapse to nucleus. Cell. 2012 Jul 06; 150(1):207-21. PMID: 22770221; PMCID: PMC4037152.
    20. Meer EJ, Wang DO, Kim S, Barr I, Guo F, Martin KC. Identification of a cis-acting element that localizes mRNA to synapses. Proc Natl Acad Sci U S A. 2012 Mar 20; 109(12):4639-44. PMID: 22383561; PMCID: PMC3311331.
    21. Ho VM, Lee JA, Martin KC. The cell biology of synaptic plasticity. Science. 2011 Nov 04; 334(6056):623-8. PMID: 22053042; PMCID: PMC3286636.
    22. Ch'ng TH, Martin KC. Synapse-to-nucleus signaling. Curr Opin Neurobiol. 2011 Apr; 21(2):345-52. PMID: 21349698; PMCID: PMC3092794.
    23. Martin KC. Anchoring local translation in neurons. Cell. 2010 May 14; 141(4):566-8. PMID: 20478248; PMCID: PMC3206092.
    24. Wang DO, Martin KC, Zukin RS. Spatially restricting gene expression by local translation at synapses. Trends Neurosci. 2010 Apr; 33(4):173-82. PMID: 20303187; PMCID: PMC3503250.
    25. Jeffrey RA, Ch'ng TH, O'Dell TJ, Martin KC. Activity-dependent anchoring of importin alpha at the synapse involves regulated binding to the cytoplasmic tail of the NR1-1a subunit of the NMDA receptor. J Neurosci. 2009 Dec 16; 29(50):15613-20. PMID: 20016075; PMCID: PMC2819930.
    26. Dzudzor B, Huynh L, Thai M, Bliss JM, Nagaoka Y, Wang Y, Ch'ng TH, Jiang M, Martin KC, Colicelli J. Regulated expression of the Ras effector Rin1 in forebrain neurons. Mol Cell Neurosci. 2010 Jan; 43(1):108-16. PMID: 19837165; PMCID: PMC2818459.
    27. Zhao Y, Wang DO, Martin KC. Preparation of Aplysia sensory-motor neuronal cell cultures. J Vis Exp. 2009 Jun 08; (28). PMID: 19506547; PMCID: PMC2794885.
    28. Wang DO, Kim SM, Zhao Y, Hwang H, Miura SK, Sossin WS, Martin KC. Synapse- and stimulus-specific local translation during long-term neuronal plasticity. Science. 2009 Jun 19; 324(5934):1536-40. PMID: 19443737; PMCID: PMC2821090.
    29. Martin KC, Ephrussi A. mRNA localization: gene expression in the spatial dimension. Cell. 2009 Feb 20; 136(4):719-30. PMID: 19239891; PMCID: PMC2819924.
    30. Shobe JL, Zhao Y, Stough S, Ye X, Hsuan V, Martin KC, Carew TJ. Temporal phases of activity-dependent plasticity and memory are mediated by compartmentalized routing of MAPK signaling in aplysia sensory neurons. Neuron. 2009 Jan 15; 61(1):113-25. PMID: 19146817; PMCID: PMC4627632.
    31. Lai KO, Zhao Y, Ch'ng TH, Martin KC. Importin-mediated retrograde transport of CREB2 from distal processes to the nucleus in neurons. Proc Natl Acad Sci U S A. 2008 Nov 04; 105(44):17175-80. PMID: 18957537; PMCID: PMC2579397.
    32. Delgado JY, Coba M, Anderson CN, Thompson KR, Gray EE, Heusner CL, Martin KC, Grant SG, O'Dell TJ. NMDA receptor activation dephosphorylates AMPA receptor glutamate receptor 1 subunits at threonine 840. J Neurosci. 2007 Nov 28; 27(48):13210-21. PMID: 18045915.
      View in: PubMed
    33. Poon MM, Choi SH, Jamieson CA, Geschwind DH, Martin KC. Identification of process-localized mRNAs from cultured rodent hippocampal neurons. J Neurosci. 2006 Dec 20; 26(51):13390-9. PMID: 17182790.
      View in: PubMed
    34. Zhao Y, Leal K, Abi-Farah C, Martin KC, Sossin WS, Klein M. Isoform specificity of PKC translocation in living Aplysia sensory neurons and a role for Ca2+-dependent PKC APL I in the induction of intermediate-term facilitation. J Neurosci. 2006 Aug 23; 26(34):8847-56. PMID: 16928874.
      View in: PubMed
    35. Martin KC, Zukin RS. RNA trafficking and local protein synthesis in dendrites: an overview. J Neurosci. 2006 Jul 05; 26(27):7131-4. PMID: 16822966.
      View in: PubMed
    36. Otis KO, Thompson KR, Martin KC. Importin-mediated nuclear transport in neurons. Curr Opin Neurobiol. 2006 Jun; 16(3):329-35. PMID: 16690311.
      View in: PubMed
    37. Lyles V, Zhao Y, Martin KC. Synapse formation and mRNA localization in cultured Aplysia neurons. Neuron. 2006 Feb 02; 49(3):349-56. PMID: 16446139.
      View in: PubMed
    38. Thompson KR, Otis KO, Chen DY, Zhao Y, O'Dell TJ, Martin KC. Synapse to nucleus signaling during long-term synaptic plasticity; a role for the classical active nuclear import pathway. Neuron. 2004 Dec 16; 44(6):997-1009. PMID: 15603742.
      View in: PubMed
    39. Ormond J, Hislop J, Zhao Y, Webb N, Vaillaincourt F, Dyer JR, Ferraro G, Barker P, Martin KC, Sossin WS. ApTrkl, a Trk-like receptor, mediates serotonin- dependent ERK activation and long-term facilitation in Aplysia sensory neurons. Neuron. 2004 Nov 18; 44(4):715-28. PMID: 15541318.
      View in: PubMed
    40. Martin KC, Sun YE. To learn better, keep the HAT on. Neuron. 2004 Jun 24; 42(6):879-81. PMID: 15207231.
      View in: PubMed
    41. Martin KC. Local protein synthesis during axon guidance and synaptic plasticity. Curr Opin Neurobiol. 2004 Jun; 14(3):305-10. PMID: 15194110.
      View in: PubMed
    42. Moccia R, Chen D, Lyles V, Kapuya E, E Y, Kalachikov S, Spahn CM, Frank J, Kandel ER, Barad M, Martin KC. An unbiased cDNA library prepared from isolated Aplysia sensory neuron processes is enriched for cytoskeletal and translational mRNAs. J Neurosci. 2003 Oct 15; 23(28):9409-17. PMID: 14561869.
      View in: PubMed
    43. Zhao Y, Hegde AN, Martin KC. The ubiquitin proteasome system functions as an inhibitory constraint on synaptic strengthening. Curr Biol. 2003 May 27; 13(11):887-98. PMID: 12781127.
      View in: PubMed
    44. Martin KC. Synaptic tagging during synapse-specific long-term facilitation of Aplysia sensory-motor neurons. Neurobiol Learn Mem. 2002 Nov; 78(3):489-97. PMID: 12559829.
      View in: PubMed
    45. Martin KC, Kosik KS. Synaptic tagging -- who's it? Nat Rev Neurosci. 2002 Oct; 3(10):813-20. PMID: 12360325.
      View in: PubMed
    46. Martin KC. Arc mRNA dynamics: return to sender--the NMDA receptor provides the targeting address for Arc mRNA. Trends Neurosci. 2001 Nov; 24(11):621-3. PMID: 11672783.
      View in: PubMed
    47. Martin KC, Barad M, Kandel ER. Local protein synthesis and its role in synapse-specific plasticity. Curr Opin Neurobiol. 2000 Oct; 10(5):587-92. PMID: 11084321.
      View in: PubMed