Loading...

Horwitz Marcus A.

TitleProfessor
InstitutionUniversity of California Los Angeles
DepartmentMedicine
AddressCHS
Los Angeles CA 90095
Phone310-206-0074
vCardDownload vCard
    Other Positions
    TitleProfessor

    TitleProfessor


    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Clemens DL, Lee BY, Plamthottam S, Tullius MV, Wang R, Yu CJ, Li Z, Dillon BJ, Zink JI, Horwitz MA. Nanoparticle formulation of moxifloxacin and intramuscular route of delivery improve antibiotic pharmacokinetics and treatment of pneumonic tularemia in a mouse model. ACS Infect Dis. 2018 Nov 27. PMID: 30480992.
      View in: PubMed
    2. Tullius MV, Nava S, Horwitz MA. PPE37 is essential for Mycobacterium tuberculosis heme-iron acquisition (HIA) and a defective PPE37 in Mycobacterium bovis BCG prevents HIA. Infect Immun. 2018 Nov 19. PMID: 30455201.
      View in: PubMed
    3. Lee BY, Clemens DL, Silva A, Dillon BJ, Masleša-Galic S, Nava S, Ho CM, Horwitz MA. Ultra-rapid near universal TB drug regimen identified via parabolic response surface platform cures mice of both conventional and high susceptibility. PLoS One. 2018; 13(11):e0207469. PMID: 30427938.
      View in: PubMed
    4. Chen W, Cheng CA, Lee BY, Clemens DL, Huang WY, Horwitz MA, Zink JI. A Facile Strategy Enabling Both High Loading and High Release Amounts of the Water-insoluble Drug Clofazimine Using Mesoporous Silica Nanoparticles. ACS Appl Mater Interfaces. 2018 Aug 30. PMID: 30160469.
      View in: PubMed
    5. Jia Q, Horwitz MA. Live Attenuated Tularemia Vaccines for Protection Against Respiratory Challenge With Virulent F. tularensis subsp. tularensis. Front Cell Infect Microbiol. 2018; 8:154. PMID: 29868510.
      View in: PubMed
    6. Jia Q, Bowen R, Dillon BJ, Masleša-Galic S, Chang BT, Kaidi AC, Horwitz MA. Single vector platform vaccine protects against lethal respiratory challenge with Tier 1 select agents of anthrax, plague, and tularemia. Sci Rep. 2018 May 03; 8(1):7009. PMID: 29725025.
      View in: PubMed
    7. Clemens DL, Lee BY, Horwitz MA. The Francisella Type VI Secretion System. Front Cell Infect Microbiol. 2018; 8:121. PMID: 29740542.
      View in: PubMed
    8. Lee JTC, Shanina I, Chu YN, Horwitz MS, Johnson JD. Carbamazepine, a beta-cell protecting drug, reduces type 1 diabetes incidence in NOD mice. Sci Rep. 2018 Mar 15; 8(1):4588. PMID: 29545618.
      View in: PubMed
    9. Farr Zuend C, Nomellini JF, Smit J, Horwitz MS. Generation of a Dual-Target, Safe, Inexpensive Microbicide that Protects Against HIV-1 and HSV-2 Disease. Sci Rep. 2018 Feb 12; 8(1):2786. PMID: 29434285.
      View in: PubMed
    10. Saarinen NVV, Laiho JE, Richardson SJ, Zeissler M, Stone VM, Marjomäki V, Kantoluoto T, Horwitz MS, Sioofy-Khojine A, Honkimaa A, Hankaniemi MM, Flodström-Tullberg M, Hyöty H, Hytönen VP, Laitinen OH. A novel rat CVB1-VP1 monoclonal antibody 3A6 detects a broad range of enteroviruses. Sci Rep. 2018 Jan 08; 8(1):33. PMID: 29311608.
      View in: PubMed
    11. Jia Q, Dillon BJ, Masleša-Galic S, Horwitz MA. Listeria-vectored vaccine expressing the Mycobacterium tuberculosis 30 kDa major secretory protein via the constitutively active prfA* regulon boosts BCG efficacy against tuberculosis. Infect Immun. 2017 Jun 19. PMID: 28630063.
      View in: PubMed
    12. Ruehle B, Clemens DL, Lee BY, Horwitz MA, Zink JI. A Pathogen-Specific Cargo Delivery Platform Based on Mesoporous Silica Nanoparticles. J Am Chem Soc. 2017 05 17; 139(19):6663-6668. PMID: 28437093.
      View in: PubMed
    13. Stefanova D, Raychev A, Arezes J, Ruchala P, Gabayan V, Skurnik M, Dillon BJ, Horwitz MA, Ganz T, Bulut Y, Nemeth E. Endogenous hepcidin and its agonist mediate resistance to selected infections by clearing non-transferrin-bound iron. Blood. 2017 07 20; 130(3):245-257. PMID: 28465342.
      View in: PubMed
    14. Lee BY, Clemens DL, Silva A, Dillon BJ, Masleša-Galic S, Nava S, Ding X, Ho CM, Horwitz MA. Drug regimens identified and optimized by output-driven platform markedly reduce tuberculosis treatment time. Nat Commun. 2017 Jan 24; 8:14183. PMID: 28117835.
      View in: PubMed
    15. Jia Q, Bowen R, Lee BY, Dillon BJ, Masleša-Galic S, Horwitz MA. Francisella tularensis Live Vaccine Strain deficient in capB and overexpressing the fusion protein of IglA, IglB, and IglC from the bfr promoter induces improved protection against F. tularensis respiratory challenge. Vaccine. 2016 09 22; 34(41):4969-4978. PMID: 27577555.
      View in: PubMed
    16. Lee BY, Li Z, Clemens DL, Dillon BJ, Hwang AA, Zink JI, Horwitz MA. Redox-Triggered Release of Moxifloxacin from Mesoporous Silica Nanoparticles Functionalized with Disulfide Snap-Tops Enhances Efficacy Against Pneumonic Tularemia in Mice. Small. 2016 Jul; 12(27):3690-702. PMID: 27246117.
      View in: PubMed
    17. Silva A, Lee BY, Clemens DL, Kee T, Ding X, Ho CM, Horwitz MA. Output-driven feedback system control platform optimizes combinatorial therapy of tuberculosis using a macrophage cell culture model. Proc Natl Acad Sci U S A. 2016 Apr 12; 113(15):E2172-9. PMID: 27035987; PMCID: PMC4839402 [Available on 10/12/16].
    18. Cunningham CR, Champhekar A, Tullius MV, Dillon BJ, Zhen A, de la Fuente JR, Herskovitz J, Elsaesser H, Snell LM, Wilson EB, de la Torre JC, Kitchen SG, Horwitz MA, Bensinger SJ, Smale ST, Brooks DG. Type I and Type II Interferon Coordinately Regulate Suppressive Dendritic Cell Fate and Function during Viral Persistence. PLoS Pathog. 2016 Jan; 12(1):e1005356. PMID: 26808628; PMCID: PMC4726812.
    19. Li Z, Clemens DL, Lee BY, Dillon BJ, Horwitz MA, Zink JI. Mesoporous Silica Nanoparticles with pH-Sensitive Nanovalves for Delivery of Moxifloxacin Provide Improved Treatment of Lethal Pneumonic Tularemia. ACS Nano. 2015 Nov 24; 9(11):10778-89. PMID: 26435204.
      View in: PubMed
    20. Hwang AA, Lee BY, Clemens DL, Dillon BJ, Zink JI, Horwitz MA. Tuberculosis: pH-Responsive Isoniazid-Loaded Nanoparticles Markedly Improve Tuberculosis Treatment in Mice (Small 38/2015). Small. 2015 Oct; 11(38):5065. PMID: 26450161.
      View in: PubMed
    21. Casiraghi C, Márquez AC, Shanina I, Horwitz MS. Latent virus infection upregulates CD40 expression facilitating enhanced autoimmunity in a model of multiple sclerosis. Sci Rep. 2015 Sep 10; 5:13995. PMID: 26356194; PMCID: PMC4564856.
    22. Hwang AA, Lee BY, Clemens DL, Dillon BJ, Zink JI, Horwitz MA. pH-Responsive Isoniazid-Loaded Nanoparticles Markedly Improve Tuberculosis Treatment in Mice. Small. 2015 Oct; 11(38):5066-78. PMID: 26193431.
      View in: PubMed
    23. Wu YC, Wu TH, Clemens DL, Lee BY, Wen X, Horwitz MA, Teitell MA, Chiou PY. Massively parallel delivery of large cargo into mammalian cells with light pulses. Nat Methods. 2015 May; 12(5):439-44. PMID: 25849636.
      View in: PubMed
    24. Clemens DL, Ge P, Lee BY, Horwitz MA, Zhou ZH. Atomic structure of T6SS reveals interlaced array essential to function. Cell. 2015 Feb 26; 160(5):940-951. PMID: 25723168.
      View in: PubMed
    25. Lincez PJ, Shanina I, Horwitz MS. Reduced expression of the MDA5 Gene IFIH1 prevents autoimmune diabetes. Diabetes. 2015 Jun; 64(6):2184-93. PMID: 25591872.
      View in: PubMed
    26. Gillis TP, Tullius MV, Horwitz MA. rBCG30-induced immunity and cross-protection against Mycobacterium leprae challenge are enhanced by boosting with the Mycobacterium tuberculosis 30-kilodalton antigen 85B. Infect Immun. 2014 Sep; 82(9):3900-9. PMID: 25001602; PMCID: PMC4187824.
    27. Contreras H, Joens MS, McMath LM, Le VP, Tullius MV, Kimmey JM, Bionghi N, Horwitz MA, Fitzpatrick JA, Goulding CW. Characterization of a Mycobacterium tuberculosis nanocompartment and its potential cargo proteins. J Biol Chem. 2014 Jun 27; 289(26):18279-89. PMID: 24855650; PMCID: PMC4140288.
    28. Lacan G, Dang H, Middleton B, Horwitz MA, Tian J, Melega WP, Kaufman DL. Bacillus Calmette-Guerin vaccine-mediated neuroprotection is associated with regulatory T-cell induction in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. J Neurosci Res. 2013 Oct; 91(10):1292-302. PMID: 23907992.
      View in: PubMed
    29. Jia Q, Bowen R, Sahakian J, Dillon BJ, Horwitz MA. A heterologous prime-boost vaccination strategy comprising the Francisella tularensis live vaccine strain capB mutant and recombinant attenuated Listeria monocytogenes expressing F. tularensis IglC induces potent protective immunity in mice against virulent F. tularensis aerosol challenge. Infect Immun. 2013 May; 81(5):1550-61. PMID: 23439306; PMCID: PMC3647989.
    30. Casiraghi C, Shanina I, Cho S, Freeman ML, Blackman MA, Horwitz MS. Gammaherpesvirus latency accentuates EAE pathogenesis: relevance to Epstein-Barr virus and multiple sclerosis. PLoS Pathog. 2012; 8(5):e1002715. PMID: 22615572; PMCID: PMC3355105.
    31. Clemens DL, Lee BY, Xue M, Thomas CR, Meng H, Ferris D, Nel AE, Zink JI, Horwitz MA. Targeted intracellular delivery of antituberculosis drugs to Mycobacterium tuberculosis-infected macrophages via functionalized mesoporous silica nanoparticles. Antimicrob Agents Chemother. 2012 May; 56(5):2535-45. PMID: 22354311; PMCID: PMC3346638.
    32. Richer MJ, Lavallée DJ, Shanina I, Horwitz MS. Immunomodulation of antigen presenting cells promotes natural regulatory T cells that prevent autoimmune diabetes in NOD mice. PLoS One. 2012; 7(2):e31153. PMID: 22355341; PMCID: PMC3280284.
    33. Veerman KM, Carlow DA, Shanina I, Priatel JJ, Horwitz MS, Ziltener HJ. PSGL-1 regulates the migration and proliferation of CD8(+) T cells under homeostatic conditions. J Immunol. 2012 Feb 15; 188(4):1638-46. PMID: 22250093.
      View in: PubMed
    34. Clemens DL, Lee BY, Horwitz MA. O-antigen-deficient Francisella tularensis Live Vaccine Strain mutants are ingested via an aberrant form of looping phagocytosis and show altered kinetics of intracellular trafficking in human macrophages. Infect Immun. 2012 Mar; 80(3):952-67. PMID: 22202123; PMCID: PMC3294633.
    35. Duval M, Lewis CJ, Nomellini JF, Horwitz MS, Smit J, Cavacini LA. Enhanced neutralization of HIV by antibodies displayed on the S-layer of Caulobacter crescentus. Antimicrob Agents Chemother. 2011 Dec; 55(12):5547-52. PMID: 21896905; PMCID: PMC3232825.
    36. Egen JG, Rothfuchs AG, Feng CG, Horwitz MA, Sher A, Germain RN. Intravital imaging reveals limited antigen presentation and T cell effector function in mycobacterial granulomas. Immunity. 2011 May 27; 34(5):807-19. PMID: 21596592.
      View in: PubMed
    37. Tullius MV, Harmston CA, Owens CP, Chim N, Morse RP, McMath LM, Iniguez A, Kimmey JM, Sawaya MR, Whitelegge JP, Horwitz MA, Goulding CW. Discovery and characterization of a unique mycobacterial heme acquisition system. Proc Natl Acad Sci U S A. 2011 Mar 22; 108(12):5051-6. PMID: 21383189; PMCID: PMC3064333.
    38. Jia Q, Lee BY, Bowen R, Dillon BJ, Som SM, Horwitz MA. A Francisella tularensis live vaccine strain (LVS) mutant with a deletion in capB, encoding a putative capsular biosynthesis protein, is significantly more attenuated than LVS yet induces potent protective immunity in mice against F. tularensis challenge. Infect Immun. 2010 Oct; 78(10):4341-55. PMID: 20643859; PMCID: PMC2950357.
    39. Lee BY, Jethwaney D, Schilling B, Clemens DL, Gibson BW, Horwitz MA. The Mycobacterium bovis bacille Calmette-Guerin phagosome proteome. Mol Cell Proteomics. 2010 Jan; 9(1):32-53. PMID: 19815536; PMCID: PMC2808266.
    40. Richer MJ, Horwitz MS. Preventing viral-induced type 1 diabetes. Ann N Y Acad Sci. 2009 Sep; 1173:487-92. PMID: 19758190.
      View in: PubMed
    41. Poffenberger MC, Horwitz MS. IL-6 during viral-induced chronic autoimmune myocarditis. Ann N Y Acad Sci. 2009 Sep; 1173:318-25. PMID: 19758168.
      View in: PubMed
    42. Sun R, Skeiky YA, Izzo A, Dheenadhayalan V, Imam Z, Penn E, Stagliano K, Haddock S, Mueller S, Fulkerson J, Scanga C, Grover A, Derrick SC, Morris S, Hone DM, Horwitz MA, Kaufmann SH, Sadoff JC. Novel recombinant BCG expressing perfringolysin O and the over-expression of key immunodominant antigens; pre-clinical characterization, safety and protection against challenge with Mycobacterium tuberculosis. Vaccine. 2009 Jul 16; 27(33):4412-23. PMID: 19500523.
      View in: PubMed
    43. Clemens DL, Lee BY, Horwitz MA. Francisella tularensis phagosomal escape does not require acidification of the phagosome. Infect Immun. 2009 May; 77(5):1757-73. PMID: 19237528; PMCID: PMC2681761.
    44. Jia Q, Lee BY, Clemens DL, Bowen RA, Horwitz MA. Recombinant attenuated Listeria monocytogenes vaccine expressing Francisella tularensis IglC induces protection in mice against aerosolized Type A F. tularensis. Vaccine. 2009 Feb 18; 27(8):1216-29. PMID: 19126421; PMCID: PMC2654553.
    45. Hoft DF, Blazevic A, Abate G, Hanekom WA, Kaplan G, Soler JH, Weichold F, Geiter L, Sadoff JC, Horwitz MA. A new recombinant bacille Calmette-Guérin vaccine safely induces significantly enhanced tuberculosis-specific immunity in human volunteers. J Infect Dis. 2008 Nov 15; 198(10):1491-501. PMID: 18808333; PMCID: PMC2670060.
    46. Horwitz MA, Harth G, Dillon BJ, Maslesa-Galic S. Commonly administered BCG strains including an evolutionarily early strain and evolutionarily late strains of disparate genealogy induce comparable protective immunity against tuberculosis. Vaccine. 2009 Jan 14; 27(3):441-5. PMID: 19007841; PMCID: PMC2657049.
    47. Tullius MV, Harth G, Maslesa-Galic S, Dillon BJ, Horwitz MA. A Replication-Limited Recombinant Mycobacterium bovis BCG vaccine against tuberculosis designed for human immunodeficiency virus-positive persons is safer and more efficacious than BCG. Infect Immun. 2008 Nov; 76(11):5200-14. PMID: 18725418; PMCID: PMC2573348.
    48. Lee BY, Clemens DL, Horwitz MA. The metabolic activity of Mycobacterium tuberculosis, assessed by use of a novel inducible GFP expression system, correlates with its capacity to inhibit phagosomal maturation and acidification in human macrophages. Mol Microbiol. 2008 May; 68(4):1047-60. PMID: 18363792; PMCID: PMC3591484.
    49. Richer MJ, Straka N, Fang D, Shanina I, Horwitz MS. Regulatory T-cells protect from type 1 diabetes after induction by coxsackievirus infection in the context of transforming growth factor-beta. Diabetes. 2008 May; 57(5):1302-11. PMID: 18268045.
      View in: PubMed
    50. Priatel JJ, Chen X, Zenewicz LA, Shen H, Harder KW, Horwitz MS, Teh HS. Chronic immunodeficiency in mice lacking RasGRP1 results in CD4 T cell immune activation and exhaustion. J Immunol. 2007 Aug 15; 179(4):2143-52. PMID: 17675473.
      View in: PubMed
    51. Harth G, Zamecnik PC, Tabatadze D, Pierson K, Horwitz MA. Hairpin extensions enhance the efficacy of mycolyl transferase-specific antisense oligonucleotides targeting Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2007 Apr 24; 104(17):7199-204. PMID: 17438292; PMCID: PMC1855390.
    52. Clemens DL, Horwitz MA. Uptake and intracellular fate of Francisella tularensis in human macrophages. Ann N Y Acad Sci. 2007 Jun; 1105:160-86. PMID: 17435118.
      View in: PubMed
    53. Hodges YK, Weinberger HD, Stephens J, Horwitz MA, Horwitz LD. Desferri-Exochelin, a lipid-soluble, hexadentate iron chelator, effectively removes tissue iron. Transl Res. 2006 Aug; 148(2):63-71. PMID: 16890146.
      View in: PubMed
    54. Lee BY, Horwitz MA, Clemens DL. Identification, recombinant expression, immunolocalization in macrophages, and T-cell responsiveness of the major extracellular proteins of Francisella tularensis. Infect Immun. 2006 Jul; 74(7):4002-13. PMID: 16790773; PMCID: PMC1489726.
    55. Harth G, Maslesa-Galic S, Tullius MV, Horwitz MA. All four Mycobacterium tuberculosis glnA genes encode glutamine synthetase activities but only GlnA1 is abundantly expressed and essential for bacterial homeostasis. Mol Microbiol. 2005 Nov; 58(4):1157-72. PMID: 16262797.
      View in: PubMed
    56. Horwitz MA, Harth G, Dillon BJ, Maslesa-Galic S. A novel live recombinant mycobacterial vaccine against bovine tuberculosis more potent than BCG. Vaccine. 2006 Mar 06; 24(10):1593-600. PMID: 16257099.
      View in: PubMed
    57. Clemens DL, Lee BY, Horwitz MA. Francisella tularensis enters macrophages via a novel process involving pseudopod loops. Infect Immun. 2005 Sep; 73(9):5892-902. PMID: 16113308; PMCID: PMC1231130.
    58. Horwitz MA, Harth G, Dillon BJ, Maslesa-Galic S. Extraordinarily few organisms of a live recombinant BCG vaccine against tuberculosis induce maximal cell-mediated and protective immunity. Vaccine. 2006 Jan 23; 24(4):443-51. PMID: 16125825.
      View in: PubMed
    59. Horwitz MA, Harth G, Dillon BJ, Maslesa-Galic S. Enhancing the protective efficacy of Mycobacterium bovis BCG vaccination against tuberculosis by boosting with the Mycobacterium tuberculosis major secretory protein. Infect Immun. 2005 Aug; 73(8):4676-83. PMID: 16040980; PMCID: PMC1201189.
    60. Horwitz MA. Recombinant BCG expressing Mycobacterium tuberculosis major extracellular proteins. Microbes Infect. 2005 May; 7(5-6):947-54. PMID: 15919223.
      View in: PubMed
    61. Harth G, Maslesa-Galic S, Horwitz MA. A two-plasmid system for stable, selective-pressure-independent expression of multiple extracellular proteins in mycobacteria. Microbiology. 2004 Jul; 150(Pt 7):2143-51. PMID: 15256557.
      View in: PubMed
    62. Clemens DL, Lee BY, Horwitz MA. Virulent and avirulent strains of Francisella tularensis prevent acidification and maturation of their phagosomes and escape into the cytoplasm in human macrophages. Infect Immun. 2004 Jun; 72(6):3204-17. PMID: 15155622; PMCID: PMC415696.
    63. Robey IF, Peterson M, Horwitz MS, Kono DH, Stratmann T, Theofilopoulos AN, Sarvetnick N, Teyton L, Feeney AJ. Terminal deoxynucleotidyltransferase deficiency decreases autoimmune disease in diabetes-prone nonobese diabetic mice and lupus-prone MRL-Fas(lpr) mice. J Immunol. 2004 Apr 01; 172(7):4624-9. PMID: 15034081.
      View in: PubMed
    64. Tullius MV, Harth G, Horwitz MA. Glutamine synthetase GlnA1 is essential for growth of Mycobacterium tuberculosis in human THP-1 macrophages and guinea pigs. Infect Immun. 2003 Jul; 71(7):3927-36. PMID: 12819079; PMCID: PMC162033.
    65. Horwitz MA, Harth G. A new vaccine against tuberculosis affords greater survival after challenge than the current vaccine in the guinea pig model of pulmonary tuberculosis. Infect Immun. 2003 Apr; 71(4):1672-9. PMID: 12654780; PMCID: PMC152073.
    66. Harth G, Horwitz MA. Inhibition of Mycobacterium tuberculosis glutamine synthetase as a novel antibiotic strategy against tuberculosis: demonstration of efficacy in vivo. Infect Immun. 2003 Jan; 71(1):456-64. PMID: 12496196; PMCID: PMC143262.
    67. Harth G, Horwitz MA, Tabatadze D, Zamecnik PC. Targeting the Mycobacterium tuberculosis 30/32-kDa mycolyl transferase complex as a therapeutic strategy against tuberculosis: Proof of principle by using antisense technology. Proc Natl Acad Sci U S A. 2002 Nov 26; 99(24):15614-9. PMID: 12427974; PMCID: PMC137765.
    68. Clemens DL, Lee BY, Horwitz MA. The Mycobacterium tuberculosis phagosome in human macrophages is isolated from the host cell cytoplasm. Infect Immun. 2002 Oct; 70(10):5800-7. PMID: 12228310; PMCID: PMC128330.
    69. Amersi F, Nelson SK, Shen XD, Kato H, Melinek J, Kupiec-Weglinski JW, Horwitz LD, Busuttil RW, Horwitz MA. Bucillamine, a thiol antioxidant, prevents transplantation-associated reperfusion injury. Proc Natl Acad Sci U S A. 2002 Jun 25; 99(13):8915-20. PMID: 12084933; PMCID: PMC124398.
    70. Whitekus MJ, Li N, Zhang M, Wang M, Horwitz MA, Nelson SK, Horwitz LD, Brechun N, Diaz-Sanchez D, Nel AE. Thiol antioxidants inhibit the adjuvant effects of aerosolized diesel exhaust particles in a murine model for ovalbumin sensitization. J Immunol. 2002 Mar 01; 168(5):2560-7. PMID: 11859152.
      View in: PubMed
    71. Horwitz MS, Evans CF, Mcgavern DB, Rodriguez M, Oldstone MBA. Primary demyelination in transgenic mice expressing interferon-gamma. Nat Med. 1997 Sep; 3(9):1037-1041. PMID: 9288735.
      View in: PubMed