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Mahler Michael E

Title(s)Professor, Neurology
Phone310-268-3560
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Darrah E, Martinez-Prat L, Mahler M. Clinical Utility of Antipeptidyl Arginine Deiminase Type 4 Antibodies. J Rheumatol. 2019 Jan 15. PMID: 30647163.
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    2. Mahler M, Andrade LE, Casiano CA, Malyavantham K, Fritzler MJ. Anti-DFS70 antibodies: an update on our current understanding and their clinical usefulness. Expert Rev Clin Immunol. 2019 Jan 09. PMID: 30623687.
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    3. Martinez-Prat L, Lucia D, Ibarra C, Mahler M, Dervieux T. Antibodies targeting protein-arginine deiminase 4 (PAD4) demonstrate diagnostic value in rheumatoid arthritis. Ann Rheum Dis. 2018 Oct 08. PMID: 30297325.
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    4. Sjöwall C, Bentow C, Aure MA, Mahler M. Two-Parametric Immunological Score Development for Assessing Renal Involvement and Disease Activity in Systemic Lupus Erythematosus. J Immunol Res. 2018; 2018:1294680. PMID: 30246032.
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    5. Mahler M, Auza C. Variation in antinuclear antibody detection: need for clear expectations and additional studies. Ann Rheum Dis. 2018 Jun 29. PMID: 29960978.
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    6. Martinez-Prat L, Nissen MJ, Lamacchia C, Bentow C, Cesana L, Roux-Lombard P, Gabay C, Mahler M. Comparison of Serological Biomarkers in Rheumatoid Arthritis and Their Combination to Improve Diagnostic Performance. Front Immunol. 2018; 9:1113. PMID: 29928272.
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    7. Mummert E, Fritzler MJ, Sjöwall C, Bentow C, Mahler M. The clinical utility of anti-double-stranded DNA antibodies and the challenges of their determination. J Immunol Methods. 2018 Aug; 459:11-19. PMID: 29807021.
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    8. Mahler M. Lack of standardisation of ANA and implications for drug development and precision medicine. Ann Rheum Dis. 2018 Mar 24. PMID: 29574414.
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    9. Mahler M, Fritzler MJ. Diagnostic Utility of Anticarbamylated Protein Antibodies as Measured Using Carbamylated Fetal Calf Serum. J Rheumatol. 2018 Mar; 45(3):438-439. PMID: 29496917.
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    10. Mahler M, Fritzler MJ. Detection of myositis-specific antibodies: additional notes. Ann Rheum Dis. 2018 Feb 14. PMID: 29444906.
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    11. Chighizola CB, Pregnolato F, Andreoli L, Bodio C, Cesana L, Comerio C, Gerosa M, Grossi C, Kumar R, Lazzaroni MG, Mahler M, Mattia E, Nalli C, Norman GL, Raimondo MG, Ruffatti A, Tonello M, Trespidi L, Tincani A, Borghi MO, Meroni PL. Beyond thrombosis: Anti-ß2GPI domain 1 antibodies identify late pregnancy morbidity in anti-phospholipid syndrome. J Autoimmun. 2018 Jun; 90:76-83. PMID: 29454510.
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    12. Mahler M, Bentow C, O'Malley T, Ibarra C, Conklin J, Aure MAR, Dervieux T. Performance Characteristics of Different Anti-Double-Stranded DNA Antibody Assays in the Monitoring of Systemic Lupus Erythematosus. J Immunol Res. 2017; 2017:1720902. PMID: 29464185.
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    13. Truchetet ME, Dublanc S, Barnetche T, Vittecoq O, Mariette X, Richez C, Blanco P, Mahler M, Contin-Bordes C, Schaeverbeke T. Association of the Presence of Anti-Carbamylated Protein Antibodies in Early Arthritis With a Poorer Clinical and Radiologic Outcome: Data From the French ESPOIR Cohort. Arthritis Rheumatol. 2017 12; 69(12):2292-2302. PMID: 28853240.
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    14. Alpizar-Rodriguez D, Mueller RB, Möller B, Dudler J, Ciurea A, Zufferey P, Kyburz D, Walker UA, von Mühlenen I, Roux-Lombard P, Mahler M, Lamacchia C, Courvoisier DS, Gabay C, Finckh A. Female hormonal factors and the development of anti-citrullinated protein antibodies in women at risk of rheumatoid arthritis. Rheumatology (Oxford). 2017 09 01; 56(9):1579-1585. PMID: 28859327.
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    15. Shovman O, Gilburd B, Chayat C, Amital H, Langevitz P, Watad A, Guy A, Perez D, Azoulay D, Blank M, Segal Y, Bentow C, Mahler M, Shoenfeld Y. Prevalence of anti-DFS70 antibodies in patients with and without systemic autoimmune rheumatic diseases. Clin Exp Rheumatol. 2018 Jan-Feb; 36(1):121-126. PMID: 28770702.
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    16. Vos I, Van Mol C, Trouw LA, Mahler M, Bakker JA, Van Offel J, De Clerck L, Huizinga TW. Anti-citrullinated protein antibodies in the diagnosis of rheumatoid arthritis (RA): diagnostic performance of automated anti-CCP-2 and anti-CCP-3 antibodies assays. Clin Rheumatol. 2017 Jul; 36(7):1487-1492. PMID: 28578492.
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    17. Demoruelle MK, Harrall KK, Ho L, Purmalek MM, Seto NL, Rothfuss HM, Weisman MH, Solomon JJ, Fischer A, Okamoto Y, Kelmenson LB, Parish MC, Feser M, Fleischer C, Anderson C, Mahler M, Norris JM, Kaplan MJ, Cherrington BD, Holers VM, Deane KD. Anti-Citrullinated Protein Antibodies Are Associated With Neutrophil Extracellular Traps in the Sputum in Relatives of Rheumatoid Arthritis Patients. Arthritis Rheumatol. 2017 06; 69(6):1165-1175. PMID: 28182854.
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    18. Verheul MK, Yee A, Seaman A, Janssen GM, van Veelen PA, Drijfhout JW, Toes REM, Mahler M, Trouw LA. Identification of carbamylated alpha 1 anti-trypsin (A1AT) as an antigenic target of anti-CarP antibodies in patients with rheumatoid arthritis. J Autoimmun. 2017 Jun; 80:77-84. PMID: 28291659.
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    19. Mahler M, Fritzler M. Commentary on the recent international multicentre study (EUVAS) on antineutrophil cytoplasmic antibodies. Ann Rheum Dis. 2017 Oct; 76(10):e38. PMID: 28274914.
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    20. Van Erp SJ, Verheul MK, Levarht EW, van der Reijden JJ, van der Heijde D, van Gaalen FA, Hommes DW, Norman GL, Shums Z, Mahler M, Verspaget HW, Trouw LA, van der Meulen-de Jong AE. Short article: Absence of serological rheumatoid arthritis biomarkers in inflammatory bowel disease patients with arthropathies. Eur J Gastroenterol Hepatol. 2017 Mar; 29(3):345-348. PMID: 27926664.
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    21. Alpizar-Rodriguez D, Brulhart L, Mueller RB, Möller B, Dudler J, Ciurea A, Walker UA, Von Mühlenen I, Kyburz D, Zufferey P, Mahler M, Bas S, Gascon D, Lamacchia C, Roux-Lombard P, Lauper K, Nissen MJ, Courvoisier DS, Gabay C, Finckh A. The prevalence of anticitrullinated protein antibodies increases with age in healthy individuals at risk for rheumatoid arthritis. Clin Rheumatol. 2017 Mar; 36(3):677-682. PMID: 28110385.
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    22. Bentow C, Fritzler MJ, Mummert E, Mahler M. Recognition of the dense fine speckled (DFS) pattern remains challenging: results from an international internet-based survey. Auto Immun Highlights. 2016 Dec; 7(1):8. PMID: 27395414; PMCID: PMC4939145.
    23. Seaman A, Darrah E, Infantino M, Meacci F, Manfredi M, Benucci M, Mahler M. Anti-peptidyl-arginine deaminase 3 (PAD3) antibodies as a promising marker to measure joint damage in patients with rheumatoid arthritis. Autoimmun Rev. 2016 Jul; 15(7):776-80. PMID: 26997641.
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    24. López-Hoyos M, Álvarez-Rodríguez L, Mahler M, Torices S, Calvo-Alén J, Villa I, Seaman A, Yee A, Martínez-Taboada V. Anti-carbamylated protein antibodies in patients with ageing associated inflammatory chronic disorders. Rheumatology (Oxford). 2016 Apr; 55(4):764-6. PMID: 26615029.
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    25. Mahler M, Meroni PL, Andrade LE, Khamashta M, Bizzaro N, Casiano CA, Fritzler MJ. Towards a better understanding of the clinical association of anti-DFS70 autoantibodies. Autoimmun Rev. 2016 Feb; 15(2):198-201. PMID: 26588998.
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    26. Mahler M, Bentow C, Serra J, Fritzler MJ. Detection of autoantibodies using chemiluminescence technologies. Immunopharmacol Immunotoxicol. 2016; 38(1):14-20. PMID: 26525648; PMCID: PMC4819877.
    27. Schmeling H, Mahler M, Levy DM, Moore K, Stevens AM, Wick J, McMillan JD, Horneff G, Assassi S, Charles J, Salazar G, Mayes MD, Silverman ED, Klien-Gitelman M, Lee T, Brunner HI, Reed AM, Fritzler MJ. Autoantibodies to Dense Fine Speckles in Pediatric Diseases and Controls. J Rheumatol. 2015 Dec; 42(12):2419-26. PMID: 26472409.
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    28. Andreoli L, Chighizola CB, Nalli C, Gerosa M, Borghi MO, Pregnolato F, Grossi C, Zanola A, Allegri F, Norman GL, Mahler M, Meroni PL, Tincani A. Clinical characterization of antiphospholipid syndrome by detection of IgG antibodies against ß2 -glycoprotein i domain 1 and domain 4/5: ratio of anti-domain 1 to anti-domain 4/5 as a useful new biomarker for antiphospholipid syndrome. Arthritis Rheumatol. 2015 May; 67(8):2196-204. PMID: 25939498.
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    29. Yee A, Webb T, Seaman A, Infantino M, Meacci F, Manfredi M, Benucci M, Lakos G, Favalli E, Schioppo T, Meroni PL, Mahler M. Erratum to: Anti-CarP antibodies as promising marker to measure joint damage and disease activity in patients with rheumatoid arthritis. Immunol Res. 2015 May; 62(1):126. PMID: 25796173.
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    30. Yee A, Webb T, Seaman A, Infantino M, Meacci F, Manfredi M, Benucci M, Lakos G, Favalli E, Schioppo T, Shioppo T, Meroni PL, Mahler M. Anti-CarP antibodies as promising marker to measure joint damage and disease activity in patients with rheumatoid arthritis. Immunol Res. 2015 Feb; 61(1-2):24-30. PMID: 25391608.
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    31. Bentow C, Lakos G, Rosenblum R, Bryant C, Seaman A, Mahler M. Clinical performance evaluation of a novel, automated chemiluminescent immunoassay, QUANTA Flash CTD Screen Plus. Immunol Res. 2015 Feb; 61(1-2):110-6. PMID: 25420962.
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    32. Martin L, Steber WA, Lupton TL, Mahler M, Fitch CM, McMillan JD, Schmidt DR, Fritzler MJ. Clinical and serological analysis of patients with positive anticyclic citrullinated Peptide antibodies referred through a Rheumatology Central Triage System. J Rheumatol. 2015 May; 42(5):771-7. PMID: 25641884.
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    33. Mahler M, Fritzler MJ, Satoh M. Autoantibodies to the mitochondrial RNA processing (MRP) complex also known as Th/To autoantigen. Autoimmun Rev. 2015 Mar; 14(3):254-7. PMID: 25462581.
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    34. Stinton LM, Bentow C, Mahler M, Norman GL, Eksteen B, Mason AL, Kaplan GG, Lindkvist B, Hirschfield GM, Milkiewicz P, Cheung A, Janssen HL, Fritzler MJ. PR3-ANCA: a promising biomarker in primary sclerosing cholangitis (PSC). PLoS One. 2014; 9(11):e112877. PMID: 25397578; PMCID: PMC4232573.
    35. Webb T, Lakos G, Swart A, Gürtler I, Favalli EG, Schioppo T, Mahler M. Clinical evaluation of a novel chemiluminescent immunoassay for the detection of anti-citrullinated peptide antibodies. Clin Chim Acta. 2014 Nov 01; 437:161-7. PMID: 25086283.
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    36. Mahler M, Fritzler MJ. Antinuclear antibodies in children. J Rheumatol. 2014 Jul; 41(7):1260-2. PMID: 24986962.
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    37. Mahler M, Pierangeli S, Meroni PL, Fritzler MJ. Autoantibodies in systemic autoimmune disorders. J Immunol Res. 2014; 2014:263091. PMID: 25097862; PMCID: PMC4101205.
    38. Mahler M, Satoh M, Hudson M, Baron M, Chan JY, Chan EK, Wick J, Fritzler MJ. Autoantibodies to the Rpp25 component of the Th/To complex are the most common antibodies in patients with systemic sclerosis without antibodies detectable by widely available commercial tests. J Rheumatol. 2014 Jul; 41(7):1334-43. PMID: 24931955.
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    39. Schulte-Pelkum J, Radice A, Norman GL, L?pez Hoyos M, Lakos G, Buchner C, Musset L, Miyara M, Stinton L, Mahler M. Novel clinical and diagnostic aspects of antineutrophil cytoplasmic antibodies. J Immunol Res. 2014; 2014:185416. PMID: 24995343; PMCID: PMC4068101.
    40. Mahler M, Meroni PL, Bossuyt X, Fritzler MJ. Current concepts and future directions for the assessment of autoantibodies to cellular antigens referred to as anti-nuclear antibodies. J Immunol Res. 2014; 2014:315179. PMID: 24868563; PMCID: PMC4020446.
    41. Lakos G, Norman GL, Mahler M, Martis P, Bentow C, Santora D, Fasano A. Analytical and clinical comparison of two fully automated immunoassay systems for the diagnosis of celiac disease. J Immunol Res. 2014; 2014:371263. PMID: 24741592; PMCID: PMC3987800.
    42. Mahler M, Dervieux T. Comments on recent advances and recommendations for the assessment of autoantibodies to cellular antigens referred as antinuclear antibodies. Ann Rheum Dis. 2014 Jul; 73(7):e36. PMID: 24577334.
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    43. Mahler M, Miller FW, Fritzler MJ. Idiopathic inflammatory myopathies and the anti-synthetase syndrome: a comprehensive review. Autoimmun Rev. 2014 Apr-May; 13(4-5):367-71. PMID: 24424190.
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    44. Shi J, van Veelen PA, Mahler M, Janssen GM, Drijfhout JW, Huizinga TW, Toes RE, Trouw LA. Carbamylation and antibodies against carbamylated proteins in autoimmunity and other pathologies. Autoimmun Rev. 2014 Mar; 13(3):225-30. PMID: 24176675.
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    45. Arias-Loste MT, Bonilla G, Moraleja I, Mahler M, Mieses MA, Castro B, Rivero M, Crespo J, López-Hoyos M. Presence of anti-proteinase 3 antineutrophil cytoplasmic antibodies (anti-PR3 ANCA) as serologic markers in inflammatory bowel disease. Clin Rev Allergy Immunol. 2013 Aug; 45(1):109-16. PMID: 23345025.
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    46. Mahler M, Bogdanos DP, Pavlidis P, Fritzler MJ, Csernok E, Damoiseaux J, Bentow C, Shums Z, Forbes A, Norman GL. PR3-ANCA: a promising biomarker for ulcerative colitis with extensive disease. Clin Chim Acta. 2013 Sep 23; 424:267-73. PMID: 23806819.
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    47. Mahler M, van Schaarenburg RA, Trouw LA. Anti-C1q autoantibodies, novel tests, and clinical consequences. Front Immunol. 2013; 4:117. PMID: 23717311; PMCID: PMC3653116.
    48. Mehra S, Hudson M, Mahler M, Baron M, Fritzler M. Is there an association between Ro52/TRIM21 antibodies and rheumatoid factor in systemic sclerosis? Rheumatol Int. 2014 Mar; 34(3):425-7. PMID: 23543347.
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    49. Mahler M, Fritzler MJ. The clinical significance of the dense fine speckled immunofluorescence pattern on HEp-2 cells for the diagnosis of systemic autoimmune diseases. Clin Dev Immunol. 2012; 2012:494356. PMID: 23304189; PMCID: PMC3523143.
    50. Swart A, Burlingame RW, Gürtler I, Mahler M. Third generation anti-citrullinated peptide antibody assay is a sensitive marker in rheumatoid factor negative rheumatoid arthritis. Clin Chim Acta. 2012 Dec 24; 414:266-72. PMID: 23022338.
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    51. Mahler M, Parker T, Peebles CL, Andrade LE, Swart A, Carbone Y, Ferguson DJ, Villalta D, Bizzaro N, Hanly JG, Fritzler MJ. Anti-DFS70/LEDGF antibodies are more prevalent in healthy individuals compared to patients with systemic autoimmune rheumatic diseases. J Rheumatol. 2012 Nov; 39(11):2104-10. PMID: 22942262.
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    52. Trouw LA, Mahler M. Closing the serological gap: promising novel biomarkers for the early diagnosis of rheumatoid arthritis. Autoimmun Rev. 2012 Dec; 12(2):318-22. PMID: 22664776.
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    53. Mahler M, Norman GL, Meroni PL, Khamashta M. Autoantibodies to domain 1 of beta 2 glycoprotein 1: a promising candidate biomarker for risk management in antiphospholipid syndrome. Autoimmun Rev. 2012 Dec; 12(2):313-7. PMID: 22652408.
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    54. Hudson M, Mahler M, Pope J, You D, Tatibouet S, Steele R, Baron M, Fritzler M. Clinical correlates of CENP-A and CENP-B antibodies in a large cohort of patients with systemic sclerosis. J Rheumatol. 2012 Apr; 39(4):787-94. PMID: 22467948.
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    55. Hudson M, Pope J, Mahler M, Tatibouet S, Steele R, Baron M, Fritzler MJ. Clinical significance of antibodies to Ro52/TRIM21 in systemic sclerosis. Arthritis Res Ther. 2012 Mar 06; 14(2):R50. PMID: 22394602; PMCID: PMC3446416.
    56. Mahler M, Miyachi K, Peebles C, Fritzler MJ. The clinical significance of autoantibodies to the proliferating cell nuclear antigen (PCNA). Autoimmun Rev. 2012 Aug; 11(10):771-5. PMID: 22381917.
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    57. Mahler M, Hanly JG, Fritzler MJ. Importance of the dense fine speckled pattern on HEp-2 cells and anti-DFS70 antibodies for the diagnosis of systemic autoimmune diseases. Autoimmun Rev. 2012 Jul; 11(9):642-5. PMID: 22100330.
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    58. Mahler M, Radice A, Sinico RA, Damoiseaux J, Seaman A, Buckmelter K, Vizjak A, Buchner C, Binder WL, Fritzler MJ, Cui Z. Performance evaluation of a novel chemiluminescence assay for detection of anti-GBM antibodies: an international multicenter study. Nephrol Dial Transplant. 2012 Jan; 27(1):243-52. PMID: 21562146.
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    59. Mahler M. Sm peptides in differentiation of autoimmune diseases. Adv Clin Chem. 2011; 54:109-28. PMID: 21874759.
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    60. Mahler M, Maes L, Blockmans D, Westhovens R, Bossuyt X, Riemekasten G, Schneider S, Hiepe F, Swart A, Gürtler I, Egerer K, Fooke M, Fritzler MJ. Clinical and serological evaluation of a novel CENP-A peptide based ELISA. Arthritis Res Ther. 2010; 12(3):R99. PMID: 20487535; PMCID: PMC2911886.
    61. Friedlander AH, Mahler M, Norman KM, Ettinger RL. Parkinson disease: systemic and orofacial manifestations, medical and dental management. J Am Dent Assoc. 2009 Jun; 140(6):658-69. PMID: 19491161.
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    62. Friedlander AH, Yagiela JA, Mahler ME, Rubin R. The pathophysiology, medical management and dental implications of adult attention-deficit/hyperactivity disorder. J Am Dent Assoc. 2007 Apr; 138(4):475-82; quiz 535, 537. PMID: 17403737.
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    63. Friedlander AH, Yagiela JA, Paterno VI, Mahler ME. The neuropathology, medical management and dental implications of autism. J Am Dent Assoc. 2006 Nov; 137(11):1517-27. PMID: 17082277.
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    64. Friedlander AH, Norman DC, Mahler ME, Norman KM, Yagiela JA. Alzheimer's disease: psychopathology, medical management and dental implications. J Am Dent Assoc. 2006 Sep; 137(9):1240-51. PMID: 16946428.
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    65. Friedlander AH, Mahler ME, Yagiela JA. Restless legs syndrome: manifestations, treatment and dental implications. J Am Dent Assoc. 2006 Jun; 137(6):755-61. PMID: 16803804.
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    66. Friedlander AH, Yagiela JA, Paterno VI, Mahler ME. The pathophysiology, medical management, and dental implications of autism. J Calif Dent Assoc. 2003 Sep; 31(9):681-2, 684, 686-91. PMID: 14560872.
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    67. Friedlander AH, Yagiela JA, Paterno VI, Mahler ME. The pathophysiology, medical management, and dental implications of children and young adults having attention-deficit hyperactivity disorder. J Calif Dent Assoc. 2003 Sep; 31(9):669-78. PMID: 14560871.
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    68. Friedlander AH, Yagiela JA, Paterno VI, Mahler ME. The pathophysiology, medical management and dental implications of fragile X, Rett, and Prader-Willi syndromes. J Calif Dent Assoc. 2003 Sep; 31(9):693-702. PMID: 14560873.
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    69. Sultzer DL, Brown CV, Mandelkern MA, Mahler ME, Mendez MF, Chen ST, Cummings JL. Delusional thoughts and regional frontal/temporal cortex metabolism in Alzheimer's disease. Am J Psychiatry. 2003 Feb; 160(2):341-9. PMID: 12562582.
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    70. Sultzer DL, Chen ST, Brown CV, Mahler ME, Cummings JL, Hinkin CH, Mandelkern MA. Subcortical hyperintensities in Alzheimer's disease: associated clinical and metabolic findings. J Neuropsychiatry Clin Neurosci. 2002; 14(3):262-9. PMID: 12154149.
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