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Iacovino Michelina

Title(s)Member, CTSI
Phone(310) 222-3751
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    Other Positions
    Title(s)Assistant Professor, Department of Pediatrics


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Clarke D, Pearse Y, Kan SH, Le SQ, Sanghez V, Cooper JD, Dickson PI, Iacovino M. Genetically Corrected iPSC-Derived Neural Stem Cell Grafts Deliver Enzyme Replacement to Affect CNS Disease in Sanfilippo B Mice. Mol Ther Methods Clin Dev. 2018 Sep 21; 10:113-127. PMID: 30101150.
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    2. Sanghez V, Chen M, Li S, Chou TF, Iacovino M, Lin HJ, Lasky JL, Panosyan EH. Efficacy of Asparaginase Erwinia chrysanthemi With and Without Temozolomide Against Glioma Cells and Intracranial Mouse Medulloblastoma. Anticancer Res. 2018 05; 38(5):2627-2634. PMID: 29715082.
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    3. Sanghez V, Luzzi A, Clarke D, Kee D, Beuder S, Rux D, Osawa M, Madrenas J, Chou TF, Kyba M, Iacovino M. Notch activation is required for downregulation of HoxA3-dependent endothelial cell phenotype during blood formation. PLoS One. 2017; 12(10):e0186818. PMID: 29073173.
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    4. Le SQ, Kan SH, Clarke D, Sanghez V, Egeland M, Vondrak KN, Doherty TM, Vera MU, Iacovino M, Cooper JD, Sands MS, Dickson PI. A Humoral Immune Response Alters the Distribution of Enzyme Replacement Therapy in Murine Mucopolysaccharidosis Type I. Mol Ther Methods Clin Dev. 2018 Mar 16; 8:42-51. PMID: 29159202.
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    5. Liu J, Guo B, Chen Z, Wang N, Iacovino M, Cheng J, Roden C, Pan W, Khan S, Chen S, Kyba M, Fan R, Guo S, Lu J. miR-125b promotes MLL-AF9-driven murine acute myeloid leukemia involving a VEGFA-mediated non-cell-intrinsic mechanism. Blood. 2017 03 16; 129(11):1491-1502. PMID: 28053194.
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    6. Gong M, Antony S, Sakurai R, Liu J, Iacovino M, Rehan VK. Bone marrow mesenchymal stem cells of the intrauterine growth-restricted rat offspring exhibit enhanced adipogenic phenotype. Int J Obes (Lond). 2016 11; 40(11):1768-1775. PMID: 27599633.
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    7. Stavropoulou V, Kaspar S, Brault L, Sanders MA, Juge S, Morettini S, Tzankov A, Iacovino M, Lau IJ, Milne TA, Royo H, Kyba M, Valk PJM, Peters AHFM, Schwaller J. MLL-AF9 Expression in Hematopoietic Stem Cells Drives a Highly Invasive AML Expressing EMT-Related Genes Linked to Poor Outcome. Cancer Cell. 2016 07 11; 30(1):43-58. PMID: 27344946.
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    8. Zhang X, Gui L, Zhang X, Bulfer SL, Sanghez V, Wong DE, Lee Y, Lehmann L, Lee JS, Shih PY, Lin HJ, Iacovino M, Weihl CC, Arkin MR, Wang Y, Chou TF. Altered cofactor regulation with disease-associated p97/VCP mutations. Proc Natl Acad Sci U S A. 2015 Apr 07; 112(14):E1705-14. PMID: 25775548; PMCID: PMC4394316.
    9. Weidgang CE, Russell R, Tata PR, Kühl SJ, Illing A, Müller M, Lin Q, Brunner C, Boeckers TM, Bauer K, Kartikasari AE, Guo Y, Radenz M, Bernemann C, Weiß M, Seufferlein T, Zenke M, Iacovino M, Kyba M, Schöler HR, Kühl M, Liebau S, Kleger A. TBX3 Directs Cell-Fate Decision toward Mesendoderm. Stem Cell Reports. 2014 May 06; 2(5):747. PMID: 28081438.
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    10. Pirazzi C, Valenti L, Motta BM, Pingitore P, Hedfalk K, Mancina RM, Burza MA, Indiveri C, Ferro Y, Montalcini T, Maglio C, Dongiovanni P, Fargion S, Rametta R, Pujia A, Andersson L, Ghosal S, Levin M, Wiklund O, Iacovino M, Borén J, Romeo S. PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cells. Hum Mol Genet. 2014 Aug 01; 23(15):4077-85. PMID: 24670599; PMCID: PMC4082369.
    11. Machado CB, Kanning KC, Kreis P, Stevenson D, Crossley M, Nowak M, Iacovino M, Kyba M, Chambers D, Blanc E, Lieberam I. Reconstruction of phrenic neuron identity in embryonic stem cell-derived motor neurons. Development. 2014 Feb; 141(4):784-94. PMID: 24496616; PMCID: PMC3912827.
    12. Iacovino M, Roth ME, Kyba M. Rapid genetic modification of mouse embryonic stem cells by Inducible Cassette Exchange recombination. Methods Mol Biol. 2014; 1101:339-51. PMID: 24233789; PMCID: PMC3935508.
    13. Kitajima K, Kawaguchi M, Iacovino M, Kyba M, Hara T. Molecular functions of the LIM-homeobox transcription factor Lhx2 in hematopoietic progenitor cells derived from mouse embryonic stem cells. Stem Cells. 2013 Dec; 31(12):2680-9. PMID: 23922318.
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    14. Mahadevan S, Wen S, Wan YW, Peng HH, Otta S, Liu Z, Iacovino M, Mahen EM, Kyba M, Sadikovic B, Van den Veyver IB. NLRP7 affects trophoblast lineage differentiation, binds to overexpressed YY1 and alters CpG methylation. Hum Mol Genet. 2014 Feb 01; 23(3):706-16. PMID: 24105472; PMCID: PMC3888260.
    15. Webber BR, Iacovino M, Choi SH, Tolar J, Kyba M, Blazar BR. DNA methylation of Runx1 regulatory regions correlates with transition from primitive to definitive hematopoietic potential in vitro and in vivo. Blood. 2013 Oct 24; 122(17):2978-86. PMID: 24030384; PMCID: PMC3811172.
    16. Borges L, Iacovino M, Koyano-Nakagawa N, Baik J, Garry DJ, Kyba M, Perlingeiro RC. Expression levels of endoglin distinctively identify hematopoietic and endothelial progeny at different stages of yolk sac hematopoiesis. Stem Cells. 2013 Sep; 31(9):1893-901. PMID: 23712751; PMCID: PMC3795927.
    17. Weidgang CE, Russell R, Tata PR, Kühl SJ, Illing A, Müller M, Lin Q, Brunner C, Boeckers TM, Bauer K, Kartikasari AE, Guo Y, Radenz M, Bernemann C, Weiß M, Seufferlein T, Zenke M, Iacovino M, Kyba M, Schöler HR, Kühl M, Liebau S, Kleger A. TBX3 Directs Cell-Fate Decision toward Mesendoderm. Stem Cell Reports. 2013; 1(3):248-65. PMID: 24319661; PMCID: PMC3849240.
    18. Chan SS, Shi X, Toyama A, Arpke RW, Dandapat A, Iacovino M, Kang J, Le G, Hagen HR, Garry DJ, Kyba M. Mesp1 patterns mesoderm into cardiac, hematopoietic, or skeletal myogenic progenitors in a context-dependent manner. Cell Stem Cell. 2013 May 02; 12(5):587-601. PMID: 23642367; PMCID: PMC3646300.
    19. Behrens AN, Iacovino M, Lohr JL, Ren Y, Zierold C, Harvey RP, Kyba M, Garry DJ, Martin CM. Nkx2-5 mediates differential cardiac differentiation through interaction with Hoxa10. Stem Cells Dev. 2013 Aug 01; 22(15):2211-20. PMID: 23477547; PMCID: PMC3715789.
    20. Filareto A, Parker S, Darabi R, Borges L, Iacovino M, Schaaf T, Mayerhofer T, Chamberlain JS, Ervasti JM, McIvor RS, Kyba M, Perlingeiro RC. An ex vivo gene therapy approach to treat muscular dystrophy using inducible pluripotent stem cells. Nat Commun. 2013; 4:1549. PMID: 23462992; PMCID: PMC3595133.
    21. Tiberi L, van den Ameele J, Dimidschstein J, Piccirilli J, Gall D, Herpoel A, Bilheu A, Bonnefont J, Iacovino M, Kyba M, Bouschet T, Vanderhaeghen P. BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets. Nat Neurosci. 2012 Dec; 15(12):1627-35. PMID: 23160044.
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    22. Hadadeh O, Barruet E, Peiretti F, Verdier M, Bernot D, Hadjal Y, Yazidi CE, Robaglia-Schlupp A, De Paula AM, Nègre D, Iacovino M, Kyba M, Alessi MC, Binétruy B. The plasminogen activation system modulates differently adipogenesis and myogenesis of embryonic stem cells. PLoS One. 2012; 7(11):e49065. PMID: 23145071; PMCID: PMC3493518.
    23. Antonica F, Kasprzyk DF, Opitz R, Iacovino M, Liao XH, Dumitrescu AM, Refetoff S, Peremans K, Manto M, Kyba M, Costagliola S. Generation of functional thyroid from embryonic stem cells. Nature. 2012 Nov 01; 491(7422):66-71. PMID: 23051751; PMCID: PMC3687105.
    24. Koyano-Nakagawa N, Kweon J, Iacovino M, Shi X, Rasmussen TL, Borges L, Zirbes KM, Li T, Perlingeiro RC, Kyba M, Garry DJ. Etv2 is expressed in the yolk sac hematopoietic and endothelial progenitors and regulates Lmo2 gene expression. Stem Cells. 2012 Aug; 30(8):1611-23. PMID: 22628281; PMCID: PMC3651838.
    25. Borges L, Iacovino M, Mayerhofer T, Koyano-Nakagawa N, Baik J, Garry DJ, Kyba M, Letarte M, Perlingeiro RC. A critical role for endoglin in the emergence of blood during embryonic development. Blood. 2012 Jun 07; 119(23):5417-28. PMID: 22535663; PMCID: PMC3369678.
    26. van den Ameele J, Tiberi L, Bondue A, Paulissen C, Herpoel A, Iacovino M, Kyba M, Blanpain C, Vanderhaeghen P. Eomesodermin induces Mesp1 expression and cardiac differentiation from embryonic stem cells in the absence of Activin. EMBO Rep. 2012 Apr; 13(4):355-62. PMID: 22402664; PMCID: PMC3321156.
    27. Jain AK, Allton K, Iacovino M, Mahen E, Milczarek RJ, Zwaka TP, Kyba M, Barton MC. p53 regulates cell cycle and microRNAs to promote differentiation of human embryonic stem cells. PLoS Biol. 2012; 10(2):e1001268. PMID: 22389628; PMCID: PMC3289600.
    28. Zuo X, Sheng J, Lau HT, McDonald CM, Andrade M, Cullen DE, Bell FT, Iacovino M, Kyba M, Xu G, Li X. Zinc finger protein ZFP57 requires its co-factor to recruit DNA methyltransferases and maintains DNA methylation imprint in embryonic stem cells via its transcriptional repression domain. J Biol Chem. 2012 Jan 13; 287(3):2107-18. PMID: 22144682; PMCID: PMC3265890.
    29. Mazzoni EO, Mahony S, Iacovino M, Morrison CA, Mountoufaris G, Closser M, Whyte WA, Young RA, Kyba M, Gifford DK, Wichterle H. Embryonic stem cell-based mapping of developmental transcriptional programs. Nat Methods. 2011 Nov 13; 8(12):1056-8. PMID: 22081127; PMCID: PMC3228994.
    30. Iacovino M, Bosnakovski D, Fey H, Rux D, Bajwa G, Mahen E, Mitanoska A, Xu Z, Kyba M. Inducible cassette exchange: a rapid and efficient system enabling conditional gene expression in embryonic stem and primary cells. Stem Cells. 2011 Oct; 29(10):1580-8. PMID: 22039605; PMCID: PMC3622722.
    31. Liebau S, Tischendorf M, Ansorge D, Linta L, Stockmann M, Weidgang C, Iacovino M, Boeckers T, von Wichert G, Kyba M, Kleger A. An inducible expression system of the calcium-activated potassium channel 4 to study the differential impact on embryonic stem cells. Stem Cells Int. 2011; 2011:456815. PMID: 21941566; PMCID: PMC3173888.
    32. Zhu R, Iacovino M, Mahen E, Kyba M, Matin A. Transcripts that associate with the RNA binding protein, DEAD-END (DND1), in embryonic stem (ES) cells. BMC Mol Biol. 2011 Aug 18; 12:37. PMID: 21851623; PMCID: PMC3167746.
    33. Chalamalasetty RB, Dunty WC, Biris KK, Ajima R, Iacovino M, Beisaw A, Feigenbaum L, Chapman DL, Yoon JK, Kyba M, Yamaguchi TP. The Wnt3a/ß-catenin target gene Mesogenin1 controls the segmentation clock by activating a Notch signalling program. Nat Commun. 2011 Jul 12; 2:390. PMID: 21750544.
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    34. Caprioli A, Koyano-Nakagawa N, Iacovino M, Shi X, Ferdous A, Harvey RP, Olson EN, Kyba M, Garry DJ. Nkx2-5 represses Gata1 gene expression and modulates the cellular fate of cardiac progenitors during embryogenesis. Circulation. 2011 Apr 19; 123(15):1633-41. PMID: 21464046; PMCID: PMC3110259.
    35. Chen C, Chai J, Singh L, Kuo CY, Jin L, Feng T, Marzano S, Galeni S, Zhang N, Iacovino M, Qin L, Hara M, Stein R, Bromberg JS, Kyba M, Ku HT. Characterization of an in vitro differentiation assay for pancreatic-like cell development from murine embryonic stem cells: detailed gene expression analysis. Assay Drug Dev Technol. 2011 Aug; 9(4):403-19. PMID: 21395400; PMCID: PMC3148116.
    36. Iacovino M, Chong D, Szatmari I, Hartweck L, Rux D, Caprioli A, Cleaver O, Kyba M. HoxA3 is an apical regulator of haemogenic endothelium. Nat Cell Biol. 2011 Jan; 13(1):72-8. PMID: 21170035; PMCID: PMC3079247.
    37. Mallanna SK, Ormsbee BD, Iacovino M, Gilmore JM, Cox JL, Kyba M, Washburn MP, Rizzino A. Proteomic analysis of Sox2-associated proteins during early stages of mouse embryonic stem cell differentiation identifies Sox21 as a novel regulator of stem cell fate. Stem Cells. 2010 Oct; 28(10):1715-27. PMID: 20687156; PMCID: PMC3260005.
    38. Szatmari I, Iacovino M, Kyba M. The retinoid signaling pathway inhibits hematopoiesis and uncouples from the Hox genes during hematopoietic development. Stem Cells. 2010 Sep; 28(9):1518-29. PMID: 20681018; PMCID: PMC3013318.
    39. Zhao L, Dong H, Zhang CC, Kinch L, Osawa M, Iacovino M, Grishin NV, Kyba M, Huang LJ. A JAK2 interdomain linker relays Epo receptor engagement signals to kinase activation. J Biol Chem. 2009 Sep 25; 284(39):26988-98. PMID: 19638629; PMCID: PMC2785384.
    40. Iacovino M, Hernandez C, Xu Z, Bajwa G, Prather M, Kyba M. A conserved role for Hox paralog group 4 in regulation of hematopoietic progenitors. Stem Cells Dev. 2009 Jun; 18(5):783-92. PMID: 18808325; PMCID: PMC2775089.
    41. Ferdous A, Caprioli A, Iacovino M, Martin CM, Morris J, Richardson JA, Latif S, Hammer RE, Harvey RP, Olson EN, Kyba M, Garry DJ. Nkx2-5 transactivates the Ets-related protein 71 gene and specifies an endothelial/endocardial fate in the developing embryo. Proc Natl Acad Sci U S A. 2009 Jan 20; 106(3):814-9. PMID: 19129488; PMCID: PMC2630085.
    42. Iacovino M, Granycome C, Sembongi H, Bokori-Brown M, Butow RA, Holt IJ, Bateman JM. The conserved translocase Tim17 prevents mitochondrial DNA loss. Hum Mol Genet. 2009 Jan 01; 18(1):65-74. PMID: 18826960; PMCID: PMC3298863.
    43. Bondue A, Lapouge G, Paulissen C, Semeraro C, Iacovino M, Kyba M, Blanpain C. Mesp1 acts as a master regulator of multipotent cardiovascular progenitor specification. Cell Stem Cell. 2008 Jul 03; 3(1):69-84. PMID: 18593560.
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    44. Pallotta ML, Valenti D, Iacovino M, Passarella S. Two separate pathways for d-lactate oxidation by Saccharomyces cerevisiae mitochondria which differ in energy production and carrier involvement. Biochim Biophys Acta. 2004 Feb 15; 1608(2-3):104-13. PMID: 14871487.
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    45. Bateman JM, Iacovino M, Perlman PS, Butow RA. Mitochondrial DNA instability mutants of the bifunctional protein Ilv5p have altered organization in mitochondria and are targeted for degradation by Hsp78 and the Pim1p protease. J Biol Chem. 2002 Dec 06; 277(49):47946-53. PMID: 12381727.
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