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Fiala Milan

Title(s)Research Professor, Orthopaedic Hospital Research Center
Phone310-206-6392
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    CARDIOMYOPATHY, HIV1 AND CHEMOKINES
    NIH/NHLBI R01HL063639Jul 3, 1999 - Jun 30, 2003
    Role: Principal Investigator
    COCAINE AND HIV1 IN CORONARY ENDOTHELIUM
    NIH/NHLBI R01HL063065Jun 1, 1999 - Dec 31, 2004
    Role: Principal Investigator
    COCAINE, BLOOD-BRAIN BARRIER AND DISEASE PROGRESSION
    NIH/NIDA R01DA010442Jun 1, 1996 - Apr 30, 1999
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Fiala M, Restrepo L, Pellegrini M. Immunotherapy of Mild Cognitive Impairment by ?-3 Supplementation: Why Are Amyloid-ß Antibodies and ?-3 Not Working in Clinical Trials? J Alzheimers Dis. 2018; 62(3):1013-1022. PMID: 29103035.
      View in: PubMed
    2. Olivera-Perez HM, Lam L, Dang J, Jiang W, Rodriguez F, Rigali E, Weitzman S, Porter V, Rubbi L, Morselli M, Pellegrini M, Fiala M. Omega-3 fatty acids increase the unfolded protein response and improve amyloid-ß phagocytosis by macrophages of patients with mild cognitive impairment. FASEB J. 2017 10; 31(10):4359-4369. PMID: 28634213.
      View in: PubMed
    3. Fiala M, Kooij G, Wagner K, Hammock B, Pellegrini M. Modulation of innate immunity of patients with Alzheimer's disease by omega-3 fatty acids. FASEB J. 2017 08; 31(8):3229-3239. PMID: 28420693.
      View in: PubMed
    4. Famenini S, Rigali EA, Olivera-Perez HM, Dang J, Chang MT, Halder R, Rao RV, Pellegrini M, Porter V, Bredesen D, Fiala M. Increased intermediate M1-M2 macrophage polarization and improved cognition in mild cognitive impairment patients on ?-3 supplementation. FASEB J. 2017 01; 31(1):148-160. PMID: 27677546.
      View in: PubMed
    5. Lam L, Chin L, Halder RC, Sagong B, Famenini S, Sayre J, Montoya D, Rubbi L, Pellegrini M, Fiala M. Epigenetic changes in T-cell and monocyte signatures and production of neurotoxic cytokines in ALS patients. FASEB J. 2016 10; 30(10):3461-3473. PMID: 27368295.
      View in: PubMed
    6. Bredesen DE, Amos EC, Canick J, Ackerley M, Raji C, Fiala M, Ahdidan J. Reversal of cognitive decline in Alzheimer's disease. Aging (Albany NY). 2016 06; 8(6):1250-8. PMID: 27294343.
      View in: PubMed
    7. Fiala M, Terrando N, Dalli J. Specialized Pro-Resolving Mediators from Omega-3 Fatty Acids Improve Amyloid-ß Phagocytosis and Regulate Inflammation in Patients with Minor Cognitive Impairment. J Alzheimers Dis. 2016; 49(4):1191. PMID: 26756328.
      View in: PubMed
    8. Lam L, Halder RC, Montoya DJ, Rubbi L, Rinaldi A, Sagong B, Weitzman S, Rubattino R, Singh RR, Pellegrini M, Fiala M. Anti-inflammatory therapies of amyotrophic lateral sclerosis guided by immune pathways. Am J Neurodegener Dis. 2015; 4(2):28-39. PMID: 26807342; PMCID: PMC4700124.
    9. Halder RC, Almasi A, Sagong B, Leung J, Jewett A, Fiala M. Curcuminoids and ?-3 fatty acids with anti-oxidants potentiate cytotoxicity of natural killer cells against pancreatic ductal adenocarcinoma cells and inhibit interferon ? production. Front Physiol. 2015; 6:129. PMID: 26052286; PMCID: PMC4440907.
    10. Fiala M, Halder RC, Sagong B, Ross O, Sayre J, Porter V, Bredesen DE. ?-3 Supplementation increases amyloid-ß phagocytosis and resolvin D1 in patients with minor cognitive impairment. FASEB J. 2015 Jul; 29(7):2681-9. PMID: 25805829.
      View in: PubMed
    11. Fiala M. Curcumin and omega-3 fatty acids enhance NK cell-induced apoptosis of pancreatic cancer cells but curcumin inhibits interferon-? production: benefits of omega-3 with curcumin against cancer. Molecules. 2015 Feb 12; 20(2):3020-6. PMID: 25685909.
      View in: PubMed
    12. Fiala M, Pellegrini M. Development of effective therapy for sporadic ALS. Expert Opin Biol Ther. 2015; 15(8):1249. PMID: 26160493.
      View in: PubMed
    13. Fiala M, Terrando N, Dalli J. Specialized Pro-Resolving Mediators from Omega-3 Fatty Acids Improve Amyloid-ß Phagocytosis and Regulate Inflammation in Patients with Minor Cognitive Impairment. J Alzheimers Dis. 2015; 48(2):293-301. PMID: 26401996.
      View in: PubMed
    14. Fiala M, Mizwicki MT, Weitzman R, Magpantay L, Nishimoto N. Tocilizumab infusion therapy normalizes inflammation in sporadic ALS patients. Am J Neurodegener Dis. 2013; 2(2):129-39. PMID: 23844337; PMCID: PMC3703125.
    15. Mizwicki MT, Liu G, Fiala M, Magpantay L, Sayre J, Siani A, Mahanian M, Weitzman R, Hayden EY, Rosenthal MJ, Nemere I, Ringman J, Teplow DB. 1a,25-dihydroxyvitamin D3 and resolvin D1 retune the balance between amyloid-ß phagocytosis and inflammation in Alzheimer's disease patients. J Alzheimers Dis. 2013; 34(1):155-70. PMID: 23186989; PMCID: PMC4040018.
    16. Mizwicki MT, Fiala M, Magpantay L, Aziz N, Sayre J, Liu G, Siani A, Chan D, Martinez-Maza O, Chattopadhyay M, La Cava A. Tocilizumab attenuates inflammation in ALS patients through inhibition of IL6 receptor signaling. Am J Neurodegener Dis. 2012; 1(3):305-15. PMID: 23383400; PMCID: PMC3560466.
    17. Fiala M, Avagyan H, Merino JJ, Bernas M, Valdivia J, Espinosa-Jeffrey A, Witte M, Weinand M. Chemotactic and mitogenic stimuli of neuronal apoptosis in patients with medically intractable temporal lobe epilepsy. Pathophysiology. 2013 Feb; 20(1):59-69. PMID: 22444245; PMCID: PMC4038119.
    18. Liu G, Fiala M, Mizwicki MT, Sayre J, Magpantay L, Siani A, Mahanian M, Chattopadhyay M, La Cava A, Wiedau-Pazos M. Neuronal phagocytosis by inflammatory macrophages in ALS spinal cord: inhibition of inflammation by resolvin D1. Am J Neurodegener Dis. 2012; 1(1):60-74. PMID: 22787561.
      View in: PubMed
    19. Mizwicki MT, Menegaz D, Zhang J, Barrientos-Durán A, Tse S, Cashman JR, Griffin PR, Fiala M. Genomic and nongenomic signaling induced by 1a,25(OH)2-vitamin D3 promotes the recovery of amyloid-ß phagocytosis by Alzheimer's disease macrophages. J Alzheimers Dis. 2012; 29(1):51-62. PMID: 22207005.
      View in: PubMed
    20. Fiala M, Porter V. Delineating Alzheimer's disease progression with MGAT3, a biomarker for improved prognosis and personalized therapy. Biomark Med. 2011 Oct; 5(5):645-7. PMID: 22003913.
      View in: PubMed
    21. Fiala M, Mahanian M, Rosenthal M, Mizwicki MT, Tse E, Cho T, Sayre J, Weitzman R, Porter V. MGAT3 mRNA: a biomarker for prognosis and therapy of Alzheimer's disease by vitamin D and curcuminoids. J Alzheimers Dis. 2011; 25(1):135-44. PMID: 21368380.
      View in: PubMed
    22. Fiala M, Chattopadhay M, La Cava A, Tse E, Liu G, Lourenco E, Eskin A, Liu PT, Magpantay L, Tse S, Mahanian M, Weitzman R, Tong J, Nguyen C, Cho T, Koo P, Sayre J, Martinez-Maza O, Rosenthal MJ, Wiedau-Pazos M. IL-17A is increased in the serum and in spinal cord CD8 and mast cells of ALS patients. J Neuroinflammation. 2010 Nov 09; 7:76. PMID: 21062492; PMCID: PMC2992053.
    23. Fiala M. Re-balancing of inflammation and abeta immunity as a therapeutic for Alzheimer's disease-view from the bedside. CNS Neurol Disord Drug Targets. 2010 Apr; 9(2):192-6. PMID: 20205641.
      View in: PubMed
    24. Fiala M, Veerhuis R. Biomarkers of inflammation and amyloid-beta phagocytosis in patients at risk of Alzheimer disease. Exp Gerontol. 2010 Jan; 45(1):57-63. PMID: 19699791; PMCID: PMC2955441.
    25. Avagyan H, Goldenson B, Tse E, Masoumi A, Porter V, Wiedau-Pazos M, Sayre J, Ong R, Mahanian M, Koo P, Bae S, Micic M, Liu PT, Rosenthal MJ, Fiala M. Immune blood biomarkers of Alzheimer disease patients. J Neuroimmunol. 2009 May 29; 210(1-2):67-72. PMID: 19329192.
      View in: PubMed
    26. Zaghi J, Goldenson B, Inayathullah M, Lossinsky AS, Masoumi A, Avagyan H, Mahanian M, Bernas M, Weinand M, Rosenthal MJ, Espinosa-Jeffrey A, de Vellis J, Teplow DB, Fiala M. Alzheimer disease macrophages shuttle amyloid-beta from neurons to vessels, contributing to amyloid angiopathy. Acta Neuropathol. 2009 Feb; 117(2):111-24. PMID: 19139910.
      View in: PubMed
    27. Masoumi A, Goldenson B, Ghirmai S, Avagyan H, Zaghi J, Abel K, Zheng X, Espinosa-Jeffrey A, Mahanian M, Liu PT, Hewison M, Mizwickie M, Cashman J, Fiala M. 1alpha,25-dihydroxyvitamin D3 interacts with curcuminoids to stimulate amyloid-beta clearance by macrophages of Alzheimer's disease patients. J Alzheimers Dis. 2009; 17(3):703-17. PMID: 19433889.
      View in: PubMed
    28. Cashman JR, Ghirmai S, Abel KJ, Fiala M. Immune defects in Alzheimer's disease: new medications development. BMC Neurosci. 2008 Dec 03; 9 Suppl 2:S13. PMID: 19090986; PMCID: PMC2604897.
    29. Fiala M, Singer EJ, Commins D, Mirzapoiazova T, Verin A, Espinosa A, Ugen K, Bernas M, Witte M, Weinand M, Lossinsky AS. HIV-1 Antigens in Neurons of Cocaine-Abusing Patients. Open Virol J. 2008; 2:24-31. PMID: 19440461.
      View in: PubMed
    30. Fiala M, Liu PT, Espinosa-Jeffrey A, Rosenthal MJ, Bernard G, Ringman JM, Sayre J, Zhang L, Zaghi J, Dejbakhsh S, Chiang B, Hui J, Mahanian M, Baghaee A, Hong P, Cashman J. Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer's disease patients are improved by bisdemethoxycurcumin. Proc Natl Acad Sci U S A. 2007 Jul 31; 104(31):12849-54. PMID: 17652175; PMCID: PMC1937555.
    31. Fiala M, Cribbs DH, Rosenthal M, Bernard G. Phagocytosis of amyloid-beta and inflammation: two faces of innate immunity in Alzheimer's disease. J Alzheimers Dis. 2007 Jul; 11(4):457-63. PMID: 17656824.
      View in: PubMed
    32. Zhang L, Fiala M, Cashman J, Sayre J, Espinosa A, Mahanian M, Zaghi J, Badmaev V, Graves MC, Bernard G, Rosenthal M. Curcuminoids enhance amyloid-beta uptake by macrophages of Alzheimer's disease patients. J Alzheimers Dis. 2006 Sep; 10(1):1-7. PMID: 16988474.
      View in: PubMed
    33. Chiappelli F, Alwan J, Prolo P, Christensen R, Fiala M, Cajulis OS, Bernard G. Neuro-immunity in stress-related oral ulcerations: a fractal analysis. Front Biosci. 2005 Sep 01; 10:3034-41. PMID: 15970558.
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    34. Fiala M, Eshleman AJ, Cashman J, Lin J, Lossinsky AS, Suarez V, Yang W, Zhang J, Popik W, Singer E, Chiappelli F, Carro E, Weinand M, Witte M, Arthos J. Cocaine increases human immunodeficiency virus type 1 neuroinvasion through remodeling brain microvascular endothelial cells. J Neurovirol. 2005 Jul; 11(3):281-91. PMID: 16036808.
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    35. Fiala M, Lin J, Ringman J, Kermani-Arab V, Tsao G, Patel A, Lossinsky AS, Graves MC, Gustavson A, Sayre J, Sofroni E, Suarez T, Chiappelli F, Bernard G. Ineffective phagocytosis of amyloid-beta by macrophages of Alzheimer's disease patients. J Alzheimers Dis. 2005 Jun; 7(3):221-32; discussion 255-62. PMID: 16006665.
      View in: PubMed
    36. Graves MC, Fiala M, Dinglasan LA, Liu NQ, Sayre J, Chiappelli F, van Kooten C, Vinters HV. Inflammation in amyotrophic lateral sclerosis spinal cord and brain is mediated by activated macrophages, mast cells and T cells. Amyotroph Lateral Scler Other Motor Neuron Disord. 2004 Dec; 5(4):213-9. PMID: 15799549.
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    37. Bobardt MD, Salmon P, Wang L, Esko JD, Gabuzda D, Fiala M, Trono D, Van der Schueren B, David G, Gallay PA. Contribution of proteoglycans to human immunodeficiency virus type 1 brain invasion. J Virol. 2004 Jun; 78(12):6567-84. PMID: 15163749; PMCID: PMC416544.
    38. Fiala M, Murphy T, MacDougall J, Yang W, Luque A, Iruela-Arispe L, Cashman J, Buga G, Byrns RE, Barbaro G, Arthos J. HAART drugs induce mitochondrial damage and intercellular gaps and gp120 causes apoptosis. Cardiovasc Toxicol. 2004; 4(4):327-37. PMID: 15531776.
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    39. Fiala M, Popik W, Qiao JH, Lossinsky AS, Alce T, Tran K, Yang W, Roos KP, Arthos J. HIV-1 induces cardiomyopathyby cardiomyocyte invasion and gp120, Tat, and cytokine apoptotic signaling. Cardiovasc Toxicol. 2004; 4(2):97-107. PMID: 15371627.
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    40. Twu C, Liu NQ, Popik W, Bukrinsky M, Sayre J, Roberts J, Rania S, Bramhandam V, Roos KP, MacLellan WR, Fiala M. Cardiomyocytes undergo apoptosis in human immunodeficiency virus cardiomyopathy through mitochondrion- and death receptor-controlled pathways. Proc Natl Acad Sci U S A. 2002 Oct 29; 99(22):14386-91. PMID: 12379743; PMCID: PMC137893.
    41. Liu NQ, Lossinsky AS, Popik W, Li X, Gujuluva C, Kriederman B, Roberts J, Pushkarsky T, Bukrinsky M, Witte M, Weinand M, Fiala M. Human immunodeficiency virus type 1 enters brain microvascular endothelia by macropinocytosis dependent on lipid rafts and the mitogen-activated protein kinase signaling pathway. J Virol. 2002 Jul; 76(13):6689-700. PMID: 12050382; PMCID: PMC136265.
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