Guo Ming

Title(s)Member, CTSI
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    Other Positions
    Title(s)Professor, Neurology

    Title(s)Professor, Molecular & Medical Pharmacology

    Title(s)Member, Brain Research Institute

    Title(s)Member, Cell & Developmental Biology GPB Home Area

    Title(s)Member, Center for Duchenne Muscular Dystrophy

    Title(s)Member, Center for Neurodegenerative Disease Studies

    Title(s)Member, Molecular Cellular & Integrative Physiology GPB Home Area

    Title(s)Member, Neuroscience GPB Home Area

    Title(s)Member, themes

    Collapse Research 
    Collapse Research Activities and Funding
    Identifying Regulators of Degeneration due to Defective Mitochondrial DNA
    NIH/NIA R01AG061405Sep 30, 2018 - May 31, 2023
    Role: Principal Investigator
    Identifying Regulators of Degeneration Due to Defective Mitochondrial DNA
    NIH/NIA R56AG057362Sep 15, 2017 - Aug 31, 2018
    Role: Principal Investigator
    Mitochondrial DNA Quality Control and Neurodegeneration
    NIH/NINDS R01NS086057Sep 30, 2013 - Aug 31, 2017
    Role: Principal Investigator
    Studying of pink1/parkin cellular pathway in Drosophila
    NIH/NIA R01AG033410Aug 1, 2008 - May 31, 2014
    Role: Principal Investigator
    The Pink1-Parkin Pathway, Mitochondria and Parkinson's Disease
    NIH/NIA K02AG031915May 15, 2008 - Apr 30, 2014
    Role: Principal Investigator
    Identifying regulators of APP gamma secretase
    NIH/NINDS R01NS048396Apr 1, 2004 - Aug 31, 2010
    Role: Principal Investigator
    Identifying Regulators of APP Gamma Secretase
    NIH/NINDS K08NS042580Feb 15, 2002 - Jan 31, 2007
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Zhang T, Mishra P, Hay BA, Chan D, Guo M. Valosin-containing protein (VCP/p97) inhibitors relieve Mitofusin-dependent mitochondrial defects due to VCP disease mutants. Elife. 2017 03 21; 6. PMID: 28322724.
      View in: PubMed
    2. Hartenstein V, Cruz L, Lovick JK, Guo M. Developmental analysis of the dopamine-containing neurons of the Drosophila brain. J Comp Neurol. 2017 02 01; 525(2):363-379. PMID: 27350102.
      View in: PubMed
    3. Dodson MW, Leung LK, Lone M, Lizzio MA, Guo M. Novel ethyl methanesulfonate (EMS)-induced null alleles of the Drosophila homolog of LRRK2 reveal a crucial role in endolysosomal functions and autophagy in vivo. Dis Model Mech. 2014 Dec; 7(12):1351-63. PMID: 25288684; PMCID: PMC4257004.
    4. Yun J, Puri R, Yang H, Lizzio MA, Wu C, Sheng ZH, Guo M. MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin. Elife. 2014 Jun 04; 3:e01958. PMID: 24898855.
      View in: PubMed
    5. Gross GG, Lone GM, Leung LK, Hartenstein V, Guo M. X11/Mint genes control polarized localization of axonal membrane proteins in vivo. J Neurosci. 2013 May 08; 33(19):8575-86. PMID: 23658195; PMCID: PMC3865514.
    6. Guo M. Drosophila as a model to study mitochondrial dysfunction in Parkinson's disease. Cold Spring Harb Perspect Med. 2012 Nov 01; 2(11). PMID: 23024178; PMCID: PMC3543109.
    7. Dodson MW, Zhang T, Jiang C, Chen S, Guo M. Roles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioning. Hum Mol Genet. 2012 Mar 15; 21(6):1350-63. PMID: 22171073; PMCID: PMC3284123.
    8. Guo M. What have we learned from Drosophila models of Parkinson's disease? Prog Brain Res. 2010; 184:3-16. PMID: 20887867.
      View in: PubMed
    9. Li H, Guo M. Protein degradation in Parkinson disease revisited: it's complex. J Clin Invest. 2009 Mar; 119(3):442-5. PMID: 19306499; PMCID: PMC2648670.
    10. Yun J, Cao JH, Dodson MW, Clark IE, Kapahi P, Chowdhury RB, Guo M. Loss-of-function analysis suggests that Omi/HtrA2 is not an essential component of the PINK1/PARKIN pathway in vivo. J Neurosci. 2008 Dec 31; 28(53):14500-10. PMID: 19118185; PMCID: PMC2718055.
    11. Deng H, Dodson MW, Huang H, Guo M. The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila. Proc Natl Acad Sci U S A. 2008 Sep 23; 105(38):14503-8. PMID: 18799731; PMCID: PMC2567186.
    12. Gross GG, Feldman RM, Ganguly A, Wang J, Yu H, Guo M. Role of X11 and ubiquilin as in vivo regulators of the amyloid precursor protein in Drosophila. PLoS One. 2008 Jun 25; 3(6):e2495. PMID: 18575606; PMCID: PMC2429963.
    13. Ganguly A, Feldman RM, Guo M. ubiquilin antagonizes presenilin and promotes neurodegeneration in Drosophila. Hum Mol Genet. 2008 Jan 15; 17(2):293-302. PMID: 17947293.
      View in: PubMed
    14. Dodson MW, Guo M. Pink1, Parkin, DJ-1 and mitochondrial dysfunction in Parkinson's disease. Curr Opin Neurobiol. 2007 Jun; 17(3):331-7. PMID: 17499497.
      View in: PubMed
    15. Guo M, Hong EJ, Fernandes J, Zipursky SL, Hay BA. A reporter for amyloid precursor protein gamma-secretase activity in Drosophila. Hum Mol Genet. 2003 Oct 15; 12(20):2669-78. PMID: 12944419.
      View in: PubMed