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Hines Oscar

TitleChief
InstitutionUniversity of California Los Angeles
DepartmentGENERAL SURGERY
Address72-170 CHS
Campus - 690418
Los Angeles CA 90095
Phone(310) 206-0441
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    Other Positions
    TitleProfessor

    TitleProgram Director


    Collapse Research 
    Collapse Research Activities and Funding
    The Role of CXCR2 in Pancreatic Cancer
    NIH/NCI R21CA124609Jul 1, 2007 - Jun 30, 2010
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Sacks GD, Hines OJ. Safeguarding Against Conflicts of Interest in the Surgical Literature. JAMA Surg. 2018 Aug 15. PMID: 30140855.
      View in: PubMed
    2. Xu M, Chang HH, Jung X, Moro A, Chou CEN, King J, Hines OJ, Sinnett-Smith J, Rozengurt E, Eibl G. Deficiency in hormone-sensitive lipase accelerates the development of pancreatic cancer in conditional KrasG12D mice. BMC Cancer. 2018 Aug 07; 18(1):797. PMID: 30086728.
      View in: PubMed
    3. Isacoff WH, Reber HA, Bedford R, Hoos W, Rahib L, Upfill-Brown A, Donahue T, Hines OJ. Low-Dose Continuous 5-Fluorouracil Combined with Leucovorin, nab-Paclitaxel, Oxaliplatin, and Bevacizumab for Patients with Advanced Pancreatic Cancer: A Retrospective Analysis. Target Oncol. 2018 Jun 07. PMID: 29882102.
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    4. Chang HH, Moro A, Chou CEN, Dawson DW, French S, Schmidt AI, Sinnett-Smith J, Hao F, Hines OJ, Eibl G, Rozengurt E. Metformin Decreases the Incidence of Pancreatic Ductal Adenocarcinoma Promoted by Diet-induced Obesity in the Conditional KrasG12D Mouse Model. Sci Rep. 2018 Apr 12; 8(1):5899. PMID: 29651002.
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    5. Wagner JP, Lewis CE, Tillou A, Agopian VG, Quach C, Donahue TR, Hines OJ. Use of Entrustable Professional Activities in the Assessment of Surgical Resident Competency. JAMA Surg. 2018 Apr 01; 153(4):335-343. PMID: 29141086.
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    6. Elliott IA, Dann AM, Ghukasyan R, Damato L, Girgis MD, King JC, Hines OJ, Reber HA, Donahue TR. Pasireotide does not prevent postoperative pancreatic fistula: a prospective study. HPB (Oxford). 2018 May; 20(5):418-422. PMID: 29398424.
      View in: PubMed
    7. Xu M, Jung X, Hines OJ, Eibl G, Chen Y. Obesity and Pancreatic Cancer: Overview of Epidemiology and Potential Prevention by Weight Loss. Pancreas. 2018 Feb; 47(2):158-162. PMID: 29346216.
      View in: PubMed
    8. Crompton JG, Jimenez JM, Chen F, Hines OJ. Man with liver abscess and pneumobilia. Surgery. 2018 Apr; 163(4):965-966. PMID: 29306540.
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    9. Elliott IA, Chan C, Russell TA, Dann AM, Williams JL, Damato L, Chung H, Girgis MD, Hines OJ, Reber HA, Donahue TR. Distinction of Risk Factors for Superficial vs Organ-Space Surgical Site Infections After Pancreatic Surgery. JAMA Surg. 2017 Nov 01; 152(11):1023-1029. PMID: 28700780.
      View in: PubMed
    10. Chang HH, Moro A, Takakura K, Su HY, Mo A, Nakanishi M, Waldron RT, French SW, Dawson DW, Hines OJ, Li G, Go VLW, Sinnett-Smith J, Pandol SJ, Lugea A, Gukovskaya AS, Duff MO, Rosenberg DW, Rozengurt E, Eibl G. Incidence of pancreatic cancer is dramatically increased by a high fat, high calorie diet in KrasG12D mice. PLoS One. 2017; 12(9):e0184455. PMID: 28886117.
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    11. Manatsathit W, Khrucharoen U, Jensen DM, Hines OJ, Kovacs T, Ohning G, Jutabha R, Ghassemi K, Dulai GS, Machicado G. Laparotomy and intraoperative enteroscopy for obscure gastrointestinal bleeding before and after the era of video capsule endoscopy and deep enteroscopy: A tertiary center experience. Am J Surg. 2018 Apr; 215(4):603-609. PMID: 28629608.
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    12. Massoumi RL, Hines OJ. Changing Outcomes in Pregnant Surgical Patients. JAMA Surg. 2017 May 01; 152(5):442. PMID: 28114507.
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    13. Juo YY, Quach C, Hiatt J, Hines OJ, Tillou A, Burruss S. Comparative Analysis of Simulated versus Live Patient-Based FAST (Focused Assessment With Sonography for Trauma) Training. J Surg Educ. 2017 Nov - Dec; 74(6):1012-1018. PMID: 28457876.
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    14. Sugimoto M, Hines OJ, Dawson DW, Muthusamy VR, Reber HA, Donahue TR. Preoperative Treatment With FOLFIRINOX and Successful Resection for a Patient With Mixed Acinar-Endocrine Carcinoma of the Pancreas. Pancreas. 2017 Apr; 46(4):e32-e34. PMID: 28291165.
      View in: PubMed
    15. Schmidt A, Sinnett-Smith J, Young S, Chang HH, Hines OJ, Dawson DW, Rozengurt E, Eibl G. Direct growth-inhibitory effects of prostaglandin E2 in pancreatic cancer cells in vitro through an EP4/PKA-mediated mechanism. Surgery. 2017 06; 161(6):1570-1578. PMID: 28222855.
      View in: PubMed
    16. Juo YY, Hines OJ. Polyglycolic Acid Mesh in Distal Pancreatectomy: A Tool for Preventing Postoperative Pancreatic Fistula? JAMA Surg. 2017 Feb 01; 152(2):156. PMID: 27784043.
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    17. Sugimoto M, Elliott IA, Nguyen AH, Kim S, Muthusamy VR, Watson R, Hines OJ, Dawson DW, Reber HA, Donahue TR. Assessment of a Revised Management Strategy for Patients With Intraductal Papillary Mucinous Neoplasms Involving the Main Pancreatic Duct. JAMA Surg. 2017 Jan 18; 152(1):e163349. PMID: 27829085.
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    18. Williams JL, Chan CK, Toste PA, Elliott IA, Vasquez CR, Sunjaya DB, Swanson EA, Koo J, Hines OJ, Reber HA, Dawson DW, Donahue TR. Association of Histopathologic Phenotype of Periampullary Adenocarcinomas With Survival. JAMA Surg. 2017 Jan 01; 152(1):82-88. PMID: 27732711.
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    19. Hines OJ. Reply. Pancreas. 2017 Jan; 46(1):e2. PMID: 27977630.
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    20. Ankeny JS, Court CM, Hou S, Li Q, Song M, Wu D, Chen JF, Lee T, Lin M, Sho S, Rochefort MM, Girgis MD, Yao J, Wainberg ZA, Muthusamy VR, Watson RR, Donahue TR, Hines OJ, Reber HA, Graeber TG, Tseng HR, Tomlinson JS. Circulating tumour cells as a biomarker for diagnosis and staging in pancreatic cancer. Br J Cancer. 2016 06 14; 114(12):1367-75. PMID: 27300108.
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    21. Stark A, Donahue TR, Reber HA, Hines OJ. Pancreatic Cyst Disease: A Review. JAMA. 2016 05 03; 315(17):1882-93. PMID: 27139061.
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    22. Williams JL, Kadera BE, Nguyen AH, Muthusamy VR, Wainberg ZA, Hines OJ, Reber HA, Donahue TR. CA19-9 Normalization During Pre-operative Treatment Predicts Longer Survival for Patients with Locally Progressed Pancreatic Cancer. J Gastrointest Surg. 2016 07; 20(7):1331-42. PMID: 27114246; PMCID: PMC4919020 [Available on 07/01/17].
    23. Hines OJ. Opportunities to Improve Care for Surgery Patients. JAMA Surg. 2016 Apr; 151(4):337. PMID: 26558711.
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    24. Zarrinpar A, Dutson EP, Mobley C, Busuttil RW, Lewis CE, Tillou A, Cheaito A, Hines OJ, Agopian VG, Hiyama DT. Intraoperative Laparoscopic Near-Infrared Fluorescence Cholangiography to Facilitate Anatomical Identification: When to Give Indocyanine Green and How Much. Surg Innov. 2016 Aug; 23(4):360-5. PMID: 26964557.
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    25. Hertzer KM, Xu M, Moro A, Dawson DW, Du L, Li G, Chang HH, Stark AP, Jung X, Hines OJ, Eibl G. Robust Early Inflammation of the Peripancreatic Visceral Adipose Tissue During Diet-Induced Obesity in the KrasG12D Model of Pancreatic Cancer. Pancreas. 2016 Mar; 45(3):458-65. PMID: 26495779; PMCID: PMC4854638 [Available on 03/01/17].
    26. Stark AP, Sacks GD, Rochefort MM, Donahue TR, Reber HA, Tomlinson JS, Dawson DW, Eibl G, Hines OJ. Long-term survival in patients with pancreatic ductal adenocarcinoma. Surgery. 2016 06; 159(6):1520-1527. PMID: 26847803; PMCID: PMC4856542 [Available on 06/01/17].
    27. Hines OJ, Stark AP. A Cutoff of 2 cm Instead of 3 cm Would Detect More Malignant BD-IPMNs: Is There a Reason to Be Wary of the International Consensus Guidelines? Pancreas. 2016 Jan; 45(1):5-7. PMID: 26658036.
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    28. Stark AP, Maciel RC, Sheppard W, Sacks G, Hines OJ. An Early Warning Score Predicts Risk of Death after In-hospital Cardiopulmonary Arrest in Surgical Patients. Am Surg. 2015 Oct; 81(10):916-21. PMID: 26463280.
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    29. Chang HH, Young SH, Sinnett-Smith J, Chou CE, Moro A, Hertzer KM, Hines OJ, Rozengurt E, Eibl G. Prostaglandin E2 activates the mTORC1 pathway through an EP4/cAMP/PKA- and EP1/Ca2+-mediated mechanism in the human pancreatic carcinoma cell line PANC-1. Am J Physiol Cell Physiol. 2015 Nov 15; 309(10):C639-49. PMID: 26310818.
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    30. Williams JL, Nguyen AH, Rochefort M, Muthusamy VR, Wainberg ZA, Dawson DW, Tomlinson JS, Hines OJ, Reber HA, Donahue TR. Pancreatic cancer patients with lymph node involvement by direct tumor extension have similar survival to those with node-negative disease. J Surg Oncol. 2015 Sep; 112(4):396-402. PMID: 26303811.
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    31. Stark AP, Chang HH, Jung X, Moro A, Hertzer K, Xu M, Schmidt A, Hines OJ, Eibl G. E-cadherin expression in obesity-associated, Kras-initiated pancreatic ductal adenocarcinoma in mice. Surgery. 2015 Dec; 158(6):1564-72. PMID: 26297056; PMCID: PMC4637247 [Available on 12/01/16].
    32. Xu M, Hines OJ. Long-term Survival After Pancreatic Cancer: Hope Has Arrived. JAMA Surg. 2015 Aug; 150(8):710-1. PMID: 26061772.
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    33. Sacks GD, Lawson EH, Tillou A, Hines OJ. Morbidity and Mortality Conference 2.0. Ann Surg. 2015 Aug; 262(2):228-9. PMID: 26164430.
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    34. Chari ST, Kelly K, Hollingsworth MA, Thayer SP, Ahlquist DA, Andersen DK, Batra SK, Brentnall TA, Canto M, Cleeter DF, Firpo MA, Gambhir SS, Go VL, Hines OJ, Kenner BJ, Klimstra DS, Lerch MM, Levy MJ, Maitra A, Mulvihill SJ, Petersen GM, Rhim AD, Simeone DM, Srivastava S, Tanaka M, Vinik AI, Wong D. Early detection of sporadic pancreatic cancer: summative review. Pancreas. 2015 Jul; 44(5):693-712. PMID: 25931254; PMCID: PMC4467589.
    35. Tai DS, Shen N, Szot GL, Posselt A, Feduska NJ, Habashy A, Clerkin B, Core E, Busuttil RW, Hines OJ, Reber HA, Lipshutz GS. Autologous islet transplantation with remote islet isolation after pancreas resection for chronic pancreatitis. JAMA Surg. 2015 Feb; 150(2):118-24. PMID: 25494212.
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    36. Stark A, Hines OJ. Endoscopic and operative palliation strategies for pancreatic ductal adenocarcinoma. Semin Oncol. 2015 Feb; 42(1):163-76. PMID: 25726060.
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    37. Nguyen AH, Toste PA, Farrell JJ, Clerkin BM, Williams J, Muthusamy VR, Watson RR, Tomlinson JS, Hines OJ, Reber HA, Donahue TR. Current recommendations for surveillance and surgery of intraductal papillary mucinous neoplasms may overlook some patients with cancer. J Gastrointest Surg. 2015 Feb; 19(2):258-65. PMID: 25373706; PMCID: PMC4305480.
    38. Nguyen D, Dawson DW, Hines OJ, Reber HA, Donahue TR. Mucinous cystic neoplasms of the pancreas: are we overestimating malignant potential? Am Surg. 2014 Oct; 80(10):915-9. PMID: 25264629.
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    39. Gifford E, Galante J, Kaji AH, Nguyen V, Nelson MT, Sidwell RA, Hartranft T, Jarman B, Melcher M, Reeves M, Reid C, Jacobsen GR, Thompson J, Are C, Smith B, Arnell T, Hines OJ, de Virgilio C. Factors associated with general surgery residents' desire to leave residency programs: a multi-institutional study. JAMA Surg. 2014 Sep; 149(9):948-53. PMID: 25075473.
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    40. Wagner JP, Chen DC, Donahue TR, Quach C, Hines OJ, Hiatt JR, Tillou A. Assessment of resident operative performance using a real-time mobile Web system: preparing for the milestone age. J Surg Educ. 2014 Nov-Dec; 71(6):e41-6. PMID: 25037504.
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    41. Hines OJ. 2014 Society of University Surgeons presidential address. Surgery. 2014 Aug; 156(2):205-13. PMID: 24957672.
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    42. Kadera BE, Sunjaya DB, Isacoff WH, Li L, Hines OJ, Tomlinson JS, Dawson DW, Rochefort MM, Donald GW, Clerkin BM, Reber HA, Donahue TR. Locally advanced pancreatic cancer: association between prolonged preoperative treatment and lymph-node negativity and overall survival. JAMA Surg. 2014 Feb; 149(2):145-53. PMID: 24306217.
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    43. Wei CH, Gorgan TR, Elashoff DA, Hines OJ, Farrell JJ, Donahue TR. A meta-analysis of gemcitabine biomarkers in patients with pancreaticobiliary cancers. Pancreas. 2013 Nov; 42(8):1303-10. PMID: 24152955; PMCID: PMC3813307.
    44. Toste PA, Kadera BE, Tatishchev SF, Dawson DW, Clerkin BM, Muthusamy R, Watson R, Tomlinson JS, Hines OJ, Reber HA, Donahue TR. Nonfunctional pancreatic neuroendocrine tumors <2 cm on preoperative imaging are associated with a low incidence of nodal metastasis and an excellent overall survival. J Gastrointest Surg. 2013 Dec; 17(12):2105-13. PMID: 24101447.
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    45. Donald G, Sunjaya D, Donahue T, Hines OJ. Polyp on ultrasound: now what? The association between gallbladder polyps and cancer. Am Surg. 2013 Oct; 79(10):1005-8. PMID: 24160788.
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    46. Pham H, Rodriguez CE, Donald GW, Hertzer KM, Jung XS, Chang HH, Moro A, Reber HA, Hines OJ, Eibl G. miR-143 decreases COX-2 mRNA stability and expression in pancreatic cancer cells. Biochem Biophys Res Commun. 2013 Sep 13; 439(1):6-11. PMID: 23973710; PMCID: PMC3789599.
    47. Takahashi H, Chen MC, Pham H, Matsuo Y, Ishiguro H, Reber HA, Takeyama H, Hines OJ, Eibl G. Simultaneous knock-down of Bcl-xL and Mcl-1 induces apoptosis through Bax activation in pancreatic cancer cells. Biochim Biophys Acta. 2013 Dec; 1833(12):2980-2987. PMID: 23954445; PMCID: PMC3834082.
    48. Rochefort MM, Ankeny JS, Kadera BE, Donald GW, Isacoff W, Wainberg ZA, Hines OJ, Donahue TR, Reber HA, Tomlinson JS. Impact of tumor grade on pancreatic cancer prognosis: validation of a novel TNMG staging system. Ann Surg Oncol. 2013 Dec; 20(13):4322-9. PMID: 23943022.
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    49. Dawson DW, Hertzer K, Moro A, Donald G, Chang HH, Go VL, Pandol SJ, Lugea A, Gukovskaya AS, Li G, Hines OJ, Rozengurt E, Eibl G. High-fat, high-calorie diet promotes early pancreatic neoplasia in the conditional KrasG12D mouse model. Cancer Prev Res (Phila). 2013 Oct; 6(10):1064-73. PMID: 23943783; PMCID: PMC3835151.
    50. Hassan B, Bernstam E, Hines OJ, Simeone DM, Weber SM, Geller DA, Evers BM, Meric-Bernstam F. Career track of Society of University Surgeons Resident Research Award recipients. J Surg Res. 2013 Nov; 185(1):92-6. PMID: 23751805; PMCID: PMC4346242.
    51. Donald GW, Sunjaya D, Lu X, Chen F, Clerkin B, Eibl G, Li G, Tomlinson JS, Donahue TR, Reber HA, Hines OJ. Perioperative antibiotics for surgical site infection in pancreaticoduodenectomy: does the SCIP-approved regimen provide adequate coverage? Surgery. 2013 Aug; 154(2):190-6. PMID: 23664266; PMCID: PMC4601575.
    52. Camus M, Jensen DM, Ohning GV, Kovacs TO, Ghassemi KA, Jutabha R, Machicado GA, Dulai GS, Hines OJ. Severe upper gastrointestinal hemorrhage from linear gastric ulcers in large hiatal hernias: a large prospective case series of Cameron ulcers. Endoscopy. 2013; 45(5):397-400. PMID: 23616128.
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    53. Angst E, Park JL, Moro A, Lu QY, Lu X, Li G, King J, Chen M, Reber HA, Go VL, Eibl G, Hines OJ. The flavonoid quercetin inhibits pancreatic cancer growth in vitro and in vivo. Pancreas. 2013 Mar; 42(2):223-9. PMID: 23000892; PMCID: PMC3530623.
    54. Hertzer KM, Donald GW, Hines OJ. CXCR2: a target for pancreatic cancer treatment? Expert Opin Ther Targets. 2013 Jun; 17(6):667-80. PMID: 23425074; PMCID: PMC3686651.
    55. Pham H, Chen M, Takahashi H, King J, Reber HA, Hines OJ, Pandol S, Eibl G. Apigenin inhibits NNK-induced focal adhesion kinase activation in pancreatic cancer cells. Pancreas. 2012 Nov; 41(8):1306-15. PMID: 22889981; PMCID: PMC3479318.
    56. Donald G, Donahue T, Reber HA, Hines OJ. The evolving management of infected pancreatic necrosis. Am Surg. 2012 Oct; 78(10):1151-5. PMID: 23025961; PMCID: PMC3678520.
    57. Lewis CE, Peacock WJ, Tillou A, Hines OJ, Hiatt JR. A novel cadaver-based educational program in general surgery training. J Surg Educ. 2012 Nov-Dec; 69(6):693-8. PMID: 23111032.
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    58. Hines OJ, Donald GW. Endoscopic transgastric necrosectomy for infected necrotizing pancreatitis. JAMA. 2012 Mar 14; 307(10):1084-5. PMID: 22416106; PMCID: PMC3678521.
    59. King JC, Lu QY, Li G, Moro A, Takahashi H, Chen M, Go VL, Reber HA, Eibl G, Hines OJ. Evidence for activation of mutated p53 by apigenin in human pancreatic cancer. Biochim Biophys Acta. 2012 Feb; 1823(2):593-604. PMID: 22227579; PMCID: PMC3277744.
    60. Wiseman JE, Ituarte PH, Ro K, Pasternak JD, Quach CA, Tillou AK, Hines OJ, Hiatt JR, Yeh MW. The effect of a dedicated endocrine surgery program on general surgery training: a single institutional experience. Am J Surg. 2012 Jun; 203(6):782-4. PMID: 22000115.
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    61. Assifi MM, Lu X, Eibl G, Reber HA, Li G, Hines OJ. Neoadjuvant therapy in pancreatic adenocarcinoma: a meta-analysis of phase II trials. Surgery. 2011 Sep; 150(3):466-73. PMID: 21878232; PMCID: PMC3164966.
    62. Donahue TR, Isacoff WH, Hines OJ, Tomlinson JS, Farrell JJ, Bhat YM, Garon E, Clerkin B, Reber HA. Downstaging chemotherapy and alteration in the classic computed tomography/magnetic resonance imaging signs of vascular involvement in patients with pancreaticobiliary malignant tumors: influence on patient selection for surgery. Arch Surg. 2011 Jul; 146(7):836-43. PMID: 21768431.
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    63. Assifi MM, Hines OJ. Anti-angiogenic agents in pancreatic cancer: a review. Anticancer Agents Med Chem. 2011 Jun; 11(5):464-9. PMID: 21521158.
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    64. Takahashi H, Chen MC, Pham H, Angst E, King JC, Park J, Brovman EY, Ishiguro H, Harris DM, Reber HA, Hines OJ, Gukovskaya AS, Go VL, Eibl G. Baicalein, a component of Scutellaria baicalensis, induces apoptosis by Mcl-1 down-regulation in human pancreatic cancer cells. Biochim Biophys Acta. 2011 Aug; 1813(8):1465-74. PMID: 21596068; PMCID: PMC3123440.
    65. Takahashi H, Li A, Dawson DW, Hines OJ, Reber HA, Eibl G. Cyclooxygenase-2 confers growth advantage to syngeneic pancreatic cancer cells. Pancreas. 2011 Apr; 40(3):453-9. PMID: 21343834; PMCID: PMC3077942.
    66. Li A, King J, Moro A, Sugi MD, Dawson DW, Kaplan J, Li G, Lu X, Strieter RM, Burdick M, Go VL, Reber HA, Eibl G, Hines OJ. Overexpression of CXCL5 is associated with poor survival in patients with pancreatic cancer. Am J Pathol. 2011 Mar; 178(3):1340-9. PMID: 21356384; PMCID: PMC3069811.
    67. Assifi MM, Hines OJ. Appendicitis equals diverticulitis: a challenge to traditional dogma. Arch Surg. 2011 Mar; 146(3):315. PMID: 21542190.
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    68. Lewis CE, Relan A, Hines OJ, Tillou A, Hiatt JR. Morbidity and mortality as a televideoconference: a randomized prospective evaluation of learning and perceptions. J Am Coll Surg. 2011 Mar; 212(3):400-5. PMID: 21296010.
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    69. Li A, Cheng XJ, Moro A, Singh RK, Hines OJ, Eibl G. CXCR2-Dependent Endothelial Progenitor Cell Mobilization in Pancreatic Cancer Growth. Transl Oncol. 2011 Feb 01; 4(1):20-8. PMID: 21286374; PMCID: PMC3026405.
    70. Angst E, Dawson DW, Stroka D, Gloor B, Park J, Candinas D, Reber HA, Hines OJ, Eibl G. N-myc downstream regulated gene-1 expression correlates with reduced pancreatic cancer growth and increased apoptosis in vitro and in vivo. Surgery. 2011 May; 149(5):614-24. PMID: 21236457.
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    71. Assifi MM, Hines OJ. Impact of duct-to-mucosa pancreaticojejunostomy with external drainage of the pancreatic duct after pancreaticoduodenectomy. J Surg Res. 2011 Dec; 171(2):457-8. PMID: 21227462.
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    72. Angst E, Chen M, Mojadidi M, Hines OJ, Reber HA, Eibl G. Bioluminescence imaging of angiogenesis in a murine orthotopic pancreatic cancer model. Mol Imaging Biol. 2010 Dec; 12(6):570-5. PMID: 20376570; PMCID: PMC2917614.
    73. Tolan AM, Kaji AH, Quach C, Hines OJ, de Virgilio C. The electronic residency application service application can predict accreditation council for graduate medical education competency-based surgical resident performance. J Surg Educ. 2010 Nov-Dec; 67(6):444-8. PMID: 21156306.
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    74. Donahue TR, Hines OJ, Farrell JJ, Tomlinson JS, Eibl G, Reber HA. Cystic neoplasms of the pancreas: results of 114 cases. Pancreas. 2010 Nov; 39(8):1271-6. PMID: 20717069.
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    75. Su Y, Loos M, Giese N, Hines OJ, Diebold I, Görlach A, Metzen E, Pastorekova S, Friess H, Büchler P. PHD3 regulates differentiation, tumour growth and angiogenesis in pancreatic cancer. Br J Cancer. 2010 Nov 09; 103(10):1571-9. PMID: 20978507; PMCID: PMC2990580.
    76. King JC, Abeywardina S, Farrell JJ, Reber HA, Hines OJ. A modern review of the operative management of chronic pancreatitis. Am Surg. 2010 Oct; 76(10):1071-4. PMID: 21105612.
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    77. King JC, Hines OJ. Predicting exocrine insufficiency following pancreatic resection. J Surg Res. 2010 Nov; 164(1):e43-5. PMID: 20850775; PMCID: PMC2957554.
    78. de Virgilio C, Yaghoubian A, Kaji A, Collins JC, Deveney K, Dolich M, Easter D, Hines OJ, Katz S, Liu T, Mahmoud A, Melcher ML, Parks S, Reeves M, Salim A, Scherer L, Takanishi D, Waxman K. Predicting performance on the American Board of Surgery qualifying and certifying examinations: a multi-institutional study. Arch Surg. 2010 Sep; 145(9):852-6. PMID: 20855755.
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    79. Hines OJ. Minimally invasive approaches to infected pancreatic collections. Arch Surg. 2010 Sep; 145(9):825. PMID: 20873002.
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    80. Wasif N, Bentrem DJ, Farrell JJ, Ko CY, Hines OJ, Reber HA, Tomlinson JS. Invasive intraductal papillary mucinous neoplasm versus sporadic pancreatic adenocarcinoma: a stage-matched comparison of outcomes. Cancer. 2010 Jul 15; 116(14):3369-77. PMID: 20564064; PMCID: PMC2902567.
    81. Angst E, Hiatt JR, Gloor B, Reber HA, Hines OJ. Laparoscopic surgery for cancer: a systematic review and a way forward. J Am Coll Surg. 2010 Sep; 211(3):412-23. PMID: 20800199; PMCID: PMC2930894.
    82. Angst E, Dawson DW, Nguyen A, Park J, Go VL, Reber HA, Hines OJ, Eibl G. Epigenetic regulation affects N-myc downstream-regulated gene 1 expression indirectly in pancreatic cancer cells. Pancreas. 2010 Jul; 39(5):675-9. PMID: 20173668; PMCID: PMC2895953.
    83. Zhang L, Angst E, Park JL, Moro A, Dawson DW, Reber HA, Eibl G, Hines OJ, Go VL, Lu QY. Quercetin aglycone is bioavailable in murine pancreas and pancreatic xenografts. J Agric Food Chem. 2010 Jun 23; 58(12):7252-7. PMID: 20499918; PMCID: PMC2894579.
    84. Wasif N, Ko CY, Farrell J, Wainberg Z, Hines OJ, Reber H, Tomlinson JS. Impact of tumor grade on prognosis in pancreatic cancer: should we include grade in AJCC staging? Ann Surg Oncol. 2010 Sep; 17(9):2312-20. PMID: 20422460; PMCID: PMC2924500.
    85. Hines OJ. Howard A. Reber, M.D., Distinguished Professor of Surgery, UCLA School of Medicine. Langenbecks Arch Surg. 2010 Jun; 395(5):593-4. PMID: 20383522; PMCID: PMC2890081.
    86. Pham H, Chen M, Li A, King J, Angst E, Dawson DW, Park J, Reber HA, Hines OJ, Eibl G. Loss of 15-hydroxyprostaglandin dehydrogenase increases prostaglandin E2 in pancreatic tumors. Pancreas. 2010 Apr; 39(3):332-9. PMID: 19820419; PMCID: PMC2859226.
    87. Donahue TR, Kazanjian KK, Isacoff WH, Reber HA, Hines OJ. Impact of splenectomy on thrombocytopenia, chemotherapy, and survival in patients with unresectable pancreatic cancer. J Gastrointest Surg. 2010 Jun; 14(6):1012-8. PMID: 20309646; PMCID: PMC2872015.
    88. Donahue T, Hines OJ. The ZIP4 pathway in pancreatic cancer. Cancer Biol Ther. 2010 Feb; 9(3):243-5. PMID: 20104017.
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    89. Manuyakorn A, Paulus R, Farrell J, Dawson NA, Tze S, Cheung-Lau G, Hines OJ, Reber H, Seligson DB, Horvath S, Kurdistani SK, Guha C, Dawson DW. Cellular histone modification patterns predict prognosis and treatment response in resectable pancreatic adenocarcinoma: results from RTOG 9704. J Clin Oncol. 2010 Mar 10; 28(8):1358-65. PMID: 20142597; PMCID: PMC2834495.
    90. Gurlo T, Ryazantsev S, Huang CJ, Yeh MW, Reber HA, Hines OJ, O'Brien TD, Glabe CG, Butler PC. Evidence for proteotoxicity in beta cells in type 2 diabetes: toxic islet amyloid polypeptide oligomers form intracellularly in the secretory pathway. Am J Pathol. 2010 Feb; 176(2):861-9. PMID: 20042670; PMCID: PMC2808091.
    91. Hines OJ, Reber HA. Pancreatic surgery. Curr Opin Gastroenterol. 2009 Sep; 25(5):460-5. PMID: 19550315.
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    92. King JC, Reber HA, Shiraga S, Hines OJ. Pancreatic-pleural fistula is best managed by early operative intervention. Surgery. 2010 Jan; 147(1):154-9. PMID: 19744435.
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    93. King JC, Ng TT, White SC, Cortina G, Reber HA, Hines OJ. Pancreatic serous cystadenocarcinoma: a case report and review of the literature. J Gastrointest Surg. 2009 Oct; 13(10):1864-8. PMID: 19459016; PMCID: PMC2759006.
    94. Donahue TR, Hines OJ. CXCR2 and RET single nucleotide polymorphisms in pancreatic cancer. World J Surg. 2009 Apr; 33(4):710-5. PMID: 19057948.
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    95. Büchler P, Reber HA, Tomlinson JS, Hankinson O, Kallifatidis G, Friess H, Herr I, Hines OJ. Transcriptional regulation of urokinase-type plasminogen activator receptor by hypoxia-inducible factor 1 is crucial for invasion of pancreatic and liver cancer. Neoplasia. 2009 Feb; 11(2):196-206. PMID: 19177204; PMCID: PMC2631144.
    96. Lewis CE, Tillou A, Yeh MW, Quach C, Hiatt JR, Hines OJ. Web-based portfolios: a valuable tool for surgical education. J Surg Res. 2010 Jun 01; 161(1):40-6. PMID: 19345374.
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    97. Kazanjian KK, Hines OJ, Duffy JP, Yoon DY, Cortina G, Reber HA. Improved survival following pancreaticoduodenectomy to treat adenocarcinoma of the pancreas: the influence of operative blood loss. Arch Surg. 2008 Dec; 143(12):1166-71. PMID: 19075167.
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    98. Tillou A, Hiatt JR, Leonardi MJ, Quach C, Hines OJ. Protected educational rotations: a valuable paradigm shift in surgical internship. J Surg Educ. 2008 Nov-Dec; 65(6):465-9. PMID: 19059179.
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    99. Yermilov I, Jain S, Sekeris E, Bentrem DJ, Hines OJ, Reber HA, Ko CY, Tomlinson JS. Utilization of parenteral nutrition following pancreaticoduodenectomy: is routine jejunostomy tube placement warranted? Dig Dis Sci. 2009 Jul; 54(7):1582-8. PMID: 18958617.
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    100. Hines OJ, Reber HA. Pancreatic surgery. Curr Opin Gastroenterol. 2008 Sep; 24(5):603-11. PMID: 19122502.
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    101. Hasan S, Satake M, Dawson DW, Funahashi H, Angst E, Go VL, Reber HA, Hines OJ, Eibl G. Expression analysis of the prostaglandin E2 production pathway in human pancreatic cancers. Pancreas. 2008 Aug; 37(2):121-7. PMID: 18665070.
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    102. Tang RS, Weinberg B, Dawson DW, Reber H, Hines OJ, Tomlinson JS, Chaudhari V, Raman S, Farrell JJ. Evaluation of the guidelines for management of pancreatic branch-duct intraductal papillary mucinous neoplasm. Clin Gastroenterol Hepatol. 2008 Jul; 6(7):815-9; quiz 719. PMID: 18602036.
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    103. Parikh JA, McGory ML, Ko CY, Hines OJ, Tillou A, Hiatt JR. A structured conference program improves competency-based surgical education. Am J Surg. 2008 Aug; 196(2):273-9. PMID: 18558395.
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    104. King J, Kazanjian K, Matsumoto J, Reber HA, Yeh MW, Hines OJ, Eibl G. Distal pancreatectomy: incidence of postoperative diabetes. J Gastrointest Surg. 2008 Sep; 12(9):1548-53. PMID: 18543045.
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    105. Angst E, Reber HA, Hines OJ, Eibl G. Mononuclear cell-derived interleukin-1 beta confers chemoresistance in pancreatic cancer cells by upregulation of cyclooxygenase-2. Surgery. 2008 Jul; 144(1):57-65. PMID: 18571585; PMCID: PMC2601479.
    106. Funahashi H, Satake M, Hasan S, Sawai H, Newman RA, Reber HA, Hines OJ, Eibl G. Opposing effects of n-6 and n-3 polyunsaturated fatty acids on pancreatic cancer growth. Pancreas. 2008 May; 36(4):353-62. PMID: 18437081.
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    107. O'Connell JB, Maggard MA, Manunga J, Tomlinson JS, Reber HA, Ko CY, Hines OJ. Survival after resection of ampullary carcinoma: a national population-based study. Ann Surg Oncol. 2008 Jul; 15(7):1820-7. PMID: 18369675.
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    108. Lee CJ, Scheiman J, Anderson MA, Hines OJ, Reber HA, Farrell J, Kochman ML, Foley PJ, Drebin J, Oh YS, Ginsberg G, Ahmad N, Merchant NB, Isbell J, Parikh AA, Stokes JB, Bauer T, Adams RB, Simeone DM. Risk of malignancy in resected cystic tumors of the pancreas < or =3 cm in size: is it safe to observe asymptomatic patients? A multi-institutional report. J Gastrointest Surg. 2008 Feb; 12(2):234-42. PMID: 18040749.
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    109. El Fitori J, Su Y, Büchler P, Ludwig R, Giese NA, Büchler MW, Quentmeier H, Hines OJ, Herr I, Friess H. PKC 412 small-molecule tyrosine kinase inhibitor: single-compound therapy for pancreatic cancer. Cancer. 2007 Oct 01; 110(7):1457-68. PMID: 17676584.
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    110. Tomlinson JS, Jain S, Bentrem DJ, Sekeris EG, Maggard MA, Hines OJ, Reber HA, Ko CY. Accuracy of staging node-negative pancreas cancer: a potential quality measure. Arch Surg. 2007 Aug; 142(8):767-723; discussion 773-4. PMID: 17709731.
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    111. Vardanian AJ, Hines OJ, Farrell JJ, Yeh MW. Incidentally discovered tumors of the endocrine glands. Future Oncol. 2007 Aug; 3(4):463-74. PMID: 17661721.
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    112. Funahashi H, Satake M, Dawson D, Huynh NA, Reber HA, Hines OJ, Eibl G. Delayed progression of pancreatic intraepithelial neoplasia in a conditional Kras(G12D) mouse model by a selective cyclooxygenase-2 inhibitor. Cancer Res. 2007 Aug 01; 67(15):7068-71. PMID: 17652141.
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    113. Büchler P, Reber HA, Roth MM, Shiroishi M, Friess H, Hines OJ. Target therapy using a small molecule inhibitor against angiogenic receptors in pancreatic cancer. Neoplasia. 2007 Feb; 9(2):119-27. PMID: 17356708; PMCID: PMC1813933.
    114. Bhargava S, Hotz B, Hines OJ, Reber HA, Buhr HJ, Hotz HG. Suramin inhibits not only tumor growth and metastasis but also angiogenesis in experimental pancreatic cancer. J Gastrointest Surg. 2007 Feb; 11(2):171-8. PMID: 17390169.
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    115. Su Y, Büchler P, Gazdhar A, Giese N, Reber HA, Hines OJ, Giese T, Büchler MW, Friess H. Pancreatic regeneration in chronic pancreatitis requires activation of the notch signaling pathway. J Gastrointest Surg. 2006 Nov; 10(9):1230-41; discussion 1242. PMID: 17114010.
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    116. Hines OJ, Reber HA. Pancreatic surgery. Curr Opin Gastroenterol. 2006 Sep; 22(5):520-6. PMID: 16891883.
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    117. Satake M, Sawai H, Go VL, Satake K, Reber HA, Hines OJ, Eibl G. Estrogen receptors in pancreatic tumors. Pancreas. 2006 Aug; 33(2):119-27. PMID: 16868476.
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    118. Kazanjian KK, Reber HA, Hines OJ. Resection of pancreatic neuroendocrine tumors: results of 70 cases. Arch Surg. 2006 Aug; 141(8):765-9; discussion 769-70. PMID: 16924083.
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    119. Umetani N, Kim J, Hiramatsu S, Reber HA, Hines OJ, Bilchik AJ, Hoon DS. Increased integrity of free circulating DNA in sera of patients with colorectal or periampullary cancer: direct quantitative PCR for ALU repeats. Clin Chem. 2006 Jun; 52(6):1062-9. PMID: 16723681.
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    120. Kim J, Reber HA, Dry SM, Elashoff D, Chen SL, Umetani N, Kitago M, Hines OJ, Kazanjian KK, Hiramatsu S, Bilchik AJ, Yong S, Shoup M, Hoon DS. Unfavourable prognosis associated with K-ras gene mutation in pancreatic cancer surgical margins. Gut. 2006 Nov; 55(11):1598-605. PMID: 16682430; PMCID: PMC1860104.
    121. Kim J, Reber HA, Hines OJ, Kazanjian KK, Tran A, Ye X, Amersi FF, Martinez SR, Dry SM, Bilchik AJ, Hoon DS. The clinical significance of MAGEA3 expression in pancreatic cancer. Int J Cancer. 2006 May 01; 118(9):2269-75. PMID: 16331618.
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    122. Sawai H, Liu J, Reber HA, Hines OJ, Eibl G. Activation of peroxisome proliferator-activated receptor-gamma decreases pancreatic cancer cell invasion through modulation of the plasminogen activator system. Mol Cancer Res. 2006 Mar; 4(3):159-67. PMID: 16547153.
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    123. Wente MN, Keane MP, Burdick MD, Friess H, Büchler MW, Ceyhan GO, Reber HA, Strieter RM, Hines OJ. Blockade of the chemokine receptor CXCR2 inhibits pancreatic cancer cell-induced angiogenesis. Cancer Lett. 2006 Sep 28; 241(2):221-7. PMID: 16458421.
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    124. Hines OJ, Reber HA. Technique of pancreaticojejunostomy reconstruction after pancreaticoduodenectomy. J Hepatobiliary Pancreat Surg. 2006; 13(3):185-9. PMID: 16708292.
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    125. Sawai H, Okada Y, Kazanjian K, Kim J, Hasan S, Hines OJ, Reber HA, Hoon DS, Eibl G. The G691S RET polymorphism increases glial cell line-derived neurotrophic factor-induced pancreatic cancer cell invasion by amplifying mitogen-activated protein kinase signaling. Cancer Res. 2005 Dec 15; 65(24):11536-44. PMID: 16357163.
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    126. Büchler P, Gazdhar A, Schubert M, Giese N, Reber HA, Hines OJ, Giese T, Ceyhan GO, Müller M, Büchler MW, Friess H. The Notch signaling pathway is related to neurovascular progression of pancreatic cancer. Ann Surg. 2005 Dec; 242(6):791-800, discussion 800-1. PMID: 16327489; PMCID: PMC1409885.
    127. Wente MN, Eibl G, Reber HA, Friess H, Büchler MW, Hines OJ. The proteasome inhibitor MG132 induces apoptosis in human pancreatic cancer cells. Oncol Rep. 2005 Dec; 14(6):1635-8. PMID: 16273269.
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    128. Büchler P, Reber HA, Eibl G, Roth MA, Büchler MW, Friess H, Isacoff WH, Hines OJ. Combination therapy for advanced pancreatic cancer using Herceptin plus chemotherapy. Int J Oncol. 2005 Oct; 27(4):1125-30. PMID: 16142331.
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    129. Hines OJ, Reber HA. Pancreatic surgery. Curr Opin Gastroenterol. 2005 Sep; 21(5):568-72. PMID: 16093771.
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    130. Kazanjian KK, Hines OJ, Eibl G, Reber HA. Management of pancreatic fistulas after pancreaticoduodenectomy: results in 437 consecutive patients. Arch Surg. 2005 Sep; 140(9):849-54; discussion 854-6. PMID: 16172293.
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    131. Wente MN, Jain A, Kono E, Berberat PO, Giese T, Reber HA, Friess H, Büchler MW, Reiter RE, Hines OJ. Prostate stem cell antigen is a putative target for immunotherapy in pancreatic cancer. Pancreas. 2005 Aug; 31(2):119-25. PMID: 16024997.
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    132. Bhargava S, Stummeyer T, Hotz B, Hines OJ, Reber HA, Buhr HJ, Hotz HG. Selective inhibition of endothelin receptor A as an anti-angiogenic and anti-proliferative strategy for human pancreatic cancer. J Gastrointest Surg. 2005 May-Jun; 9(5):703-9. PMID: 15862267.
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    133. Guha S, Eibl G, Kisfalvi K, Fan RS, Burdick M, Reber H, Hines OJ, Strieter R, Rozengurt E. Broad-spectrum G protein-coupled receptor antagonist, [D-Arg1,D-Trp5,7,9,Leu11]SP: a dual inhibitor of growth and angiogenesis in pancreatic cancer. Cancer Res. 2005 Apr 01; 65(7):2738-45. PMID: 15805273.
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    134. Eibl G, Takata Y, Boros LG, Liu J, Okada Y, Reber HA, Hines OJ. Growth stimulation of COX-2-negative pancreatic cancer by a selective COX-2 inhibitor. Cancer Res. 2005 Feb 01; 65(3):982-90. PMID: 15705899.
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    135. Hotz HG, Hines OJ, Masood R, Hotz B, Foitzik T, Buhr HJ, Gill PS, Reber HA. VEGF antisense therapy inhibits tumor growth and improves survival in experimental pancreatic cancer. Surgery. 2005 Feb; 137(2):192-9. PMID: 15674201.
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    136. Targownik LE, Spiegel BM, Sack J, Hines OJ, Dulai GS, Gralnek IM, Farrell JJ. Colonic stent vs. emergency surgery for management of acute left-sided malignant colonic obstruction: a decision analysis. Gastrointest Endosc. 2004 Dec; 60(6):865-74. PMID: 15604999.
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    137. Eibl G, Reber HA, Hines OJ, Go VL. COX and PPAR: possible interactions in pancreatic cancer. Pancreas. 2004 Nov; 29(4):247-53. PMID: 15502639.
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    138. Kazanjian KK, Reber HA, Hines OJ. Laparoscopic gastrojejunostomy for gastric outlet obstruction in pancreatic cancer. Am Surg. 2004 Oct; 70(10):910-3. PMID: 15529849.
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    139. Hines OJ, Reber HA. Pancreatic neoplasms. Curr Opin Gastroenterol. 2004 Sep; 20(5):452-8. PMID: 15689678.
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    140. Büchler P, Reber HA, Lavey RS, Tomlinson J, Büchler MW, Friess H, Hines OJ. Tumor hypoxia correlates with metastatic tumor growth of pancreatic cancer in an orthotopic murine model. J Surg Res. 2004 Aug; 120(2):295-303. PMID: 15234226.
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    141. Büchler P, Reber HA, Büchler MW, Friess H, Lavey RS, Hines OJ. Antiangiogenic activity of genistein in pancreatic carcinoma cells is mediated by the inhibition of hypoxia-inducible factor-1 and the down-regulation of VEGF gene expression. Cancer. 2004 Jan 01; 100(1):201-10. PMID: 14692041.
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    142. Okada Y, Eibl G, Guha S, Duffy JP, Reber HA, Hines OJ. Nerve growth factor stimulates MMP-2 expression and activity and increases invasion by human pancreatic cancer cells. Clin Exp Metastasis. 2004; 21(4):285-92. PMID: 15554384.
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    143. Büchler P, Reber HA, Ullrich A, Shiroiki M, Roth M, Büchler MW, Lavey RS, Friess H, Hines OJ. Pancreatic cancer growth is inhibited by blockade of VEGF-RII. Surgery. 2003 Nov; 134(5):772-82. PMID: 14639356.
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    144. Duffy JP, Maggard M, Hiyama DT, Atkinson JB, McFadden DW, Ko CY, Hines OJ. Laparoscopic Nissen fundoplication improves quality of life in patients with atypical symptoms of gastroesophageal reflux. Am Surg. 2003 Oct; 69(10):833-8. PMID: 14570358.
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    145. Duffy JP, Hines OJ, Liu JH, Ko CY, Cortina G, Isacoff WH, Nguyen H, Leonardi M, Tompkins RK, Reber HA. Improved survival for adenocarcinoma of the ampulla of Vater: fifty-five consecutive resections. Arch Surg. 2003 Sep; 138(9):941-8; discussion 948-50. PMID: 12963649.
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    146. Okada Y, Eibl G, Duffy JP, Reber HA, Hines OJ. Glial cell-derived neurotrophic factor upregulates the expression and activation of matrix metalloproteinase-9 in human pancreatic cancer. Surgery. 2003 Aug; 134(2):293-9. PMID: 12947332.
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    147. Eibl G, Bruemmer D, Okada Y, Duffy JP, Law RE, Reber HA, Hines OJ. PGE(2) is generated by specific COX-2 activity and increases VEGF production in COX-2-expressing human pancreatic cancer cells. Biochem Biophys Res Commun. 2003 Jul 11; 306(4):887-97. PMID: 12821125.
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    148. Hotz HG, Reber HA, Hotz B, Yu T, Foitzik T, Buhr HJ, Cortina G, Hines OJ. An orthotopic nude mouse model for evaluating pathophysiology and therapy of pancreatic cancer. Pancreas. 2003 May; 26(4):e89-98. PMID: 12717279.
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    149. Büchler P, Gukovskaya AS, Mouria M, Büchler MC, Büchler MW, Friess H, Pandol SJ, Reber HA, Hines OJ. Prevention of metastatic pancreatic cancer growth in vivo by induction of apoptosis with genistein, a naturally occurring isoflavonoid. Pancreas. 2003 Apr; 26(3):264-73. PMID: 12657953.
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    150. Hotz HG, Hines OJ, Hotz B, Foitzik T, Buhr HJ, Reber HA. Evaluation of vascular endothelial growth factor blockade and matrix metalloproteinase inhibition as a combination therapy for experimental human pancreatic cancer. J Gastrointest Surg. 2003 Feb; 7(2):220-7; discussion 227-8. PMID: 12600446.
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    151. Duffy JP, Eibl G, Reber HA, Hines OJ. Influence of hypoxia and neoangiogenesis on the growth of pancreatic cancer. Mol Cancer. 2003 Jan 22; 2:12. PMID: 12605718; PMCID: PMC150383.
    152. Eibl G, Reber HA, Wente MN, Hines OJ. The selective cyclooxygenase-2 inhibitor nimesulide induces apoptosis in pancreatic cancer cells independent of COX-2. Pancreas. 2003 Jan; 26(1):33-41. PMID: 12499915.
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    153. Büchler P, Reber HA, Büchler M, Shrinkante S, Büchler MW, Friess H, Semenza GL, Hines OJ. Hypoxia-inducible factor 1 regulates vascular endothelial growth factor expression in human pancreatic cancer. Pancreas. 2003 Jan; 26(1):56-64. PMID: 12499918.
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    154. Yoon DY, Chu J, Chandler C, Hiyama S, Thompson JE, Hines OJ. Human cytokine levels in nonperforated versus perforated appendicitis: molecular serum markers for extent of disease? Am Surg. 2002 Dec; 68(12):1033-7. PMID: 12516803.
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    155. Büchler P, Reber HA, Büchler MW, Friess H, Hines OJ. VEGF-RII influences the prognosis of pancreatic cancer. Ann Surg. 2002 Dec; 236(6):738-49; discussion 749. PMID: 12454512; PMCID: PMC1422640.
    156. Mouria M, Gukovskaya AS, Jung Y, Buechler P, Hines OJ, Reber HA, Pandol SJ. Food-derived polyphenols inhibit pancreatic cancer growth through mitochondrial cytochrome C release and apoptosis. Int J Cancer. 2002 Apr 10; 98(5):761-9. PMID: 11920648.
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    157. Towfigh S, Chandler C, Hines OJ, McFadden DW. Outcomes from peptic ulcer surgery have not benefited from advances in medical therapy. Am Surg. 2002 Apr; 68(4):385-9. PMID: 11952253.
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    158. Hotz HG, Gill PS, Masood R, Hotz B, Buhr HJ, Foitzik T, Hines OJ, Reber HA. Specific targeting of tumor vasculature by diphtheria toxin-vascular endothelial growth factor fusion protein reduces angiogenesis and growth of pancreatic cancer. J Gastrointest Surg. 2002 Mar-Apr; 6(2):159-66; discussion 166. PMID: 11992800.
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    159. Yoon DY, Hines OJ, Bilchik AJ, Lewin K, Cortina G, Reber HA. Solid and papillary epithelial neoplasms of the pancreas: aggressive resection for cure. Am Surg. 2001 Dec; 67(12):1195-9. PMID: 11768829.
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    160. Maggard MA, Chandler CF, Schmit PJ, Bennion RS, Hines OJ, Thompson JE. Surgical diverticulitis: treatment options. Am Surg. 2001 Dec; 67(12):1185-9. PMID: 11768827.
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    161. Yoon DY, Buchler P, Saarikoski ST, Hines OJ, Reber HA, Hankinson O. Identification of genes differentially induced by hypoxia in pancreatic cancer cells. Biochem Biophys Res Commun. 2001 Nov 09; 288(4):882-6. PMID: 11688991.
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    162. Eibl G, Wente MN, Reber HA, Hines OJ. Peroxisome proliferator-activated receptor gamma induces pancreatic cancer cell apoptosis. Biochem Biophys Res Commun. 2001 Sep 21; 287(2):522-9. PMID: 11554760.
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    163. Büchler P, Reber HA, Büchler MC, Roth MA, Büchler MW, Friess H, Isacoff WH, Hines OJ. Therapy for pancreatic cancer with a recombinant humanized anti-HER2 antibody (herceptin). J Gastrointest Surg. 2001 Mar-Apr; 5(2):139-46. PMID: 11331475.
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    164. Hotz HG, Reber HA, Hotz B, Foitzik T, Buhr HJ, Cortina G, Hines OJ. An improved clinical model of orthotopic pancreatic cancer in immunocompetent Lewis rats. Pancreas. 2001 Mar; 22(2):113-21. PMID: 11249064.
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    165. Hotz HG, Reber HA, Hotz B, Sanghavi PC, Yu T, Foitzik T, Buhr HJ, Hines OJ. Angiogenesis inhibitor TNP-470 reduces human pancreatic cancer growth. J Gastrointest Surg. 2001 Mar-Apr; 5(2):131-8. PMID: 11331474.
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    166. Towfigh S, McFadden DW, Cortina GR, Thompson JE, Tompkins RK, Chandler C, Hines OJ. Porcelain gallbladder is not associated with gallbladder carcinoma. Am Surg. 2001 Jan; 67(1):7-10. PMID: 11206901.
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    167. Ryder NM, Guha S, Hines OJ, Reber HA, Rozengurt E. G protein-coupled receptor signaling in human ductal pancreatic cancer cells: neurotensin responsiveness and mitogenic stimulation. J Cell Physiol. 2001 Jan; 186(1):53-64. PMID: 11147814.
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    168. Gloor B, Blinman TA, Rigberg DA, Todd KE, Lane JS, Hines OJ, Reber HA. Kupffer cell blockade reduces hepatic and systemic cytokine levels and lung injury in hemorrhagic pancreatitis in rats. Pancreas. 2000 Nov; 21(4):414-20. PMID: 11075997.
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    169. Ryder NM, Ko CY, Hines OJ, Gloor B, Reber HA. Primary duodenal adenocarcinoma: a 40-year experience. Arch Surg. 2000 Sep; 135(9):1070-4; discussion 1074-5. PMID: 10982512.
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    170. Hines OJ, Ryder N, Chu J, McFadden D. Lysophosphatidic acid stimulates intestinal restitution via cytoskeletal activation and remodeling. J Surg Res. 2000 Jul; 92(1):23-8. PMID: 10864477.
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    171. Hines OJ, Reber HA. Median pancreatectomy: do the risks justify the effort? J Am Coll Surg. 2000 Jun; 190(6):715-6. PMID: 10873008.
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    172. Hotz HG, Hines OJ, Foitzik T, Reber HA. Animal models of exocrine pancreatic cancer. Int J Colorectal Dis. 2000 Jun; 15(3):136-43. PMID: 10954185.
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    173. Towfigh S, Heisler T, Rigberg DA, Hines OJ, Chu J, McFadden DW, Chandler C. Intestinal ischemia and the gut-liver axis: an in vitro model. J Surg Res. 2000 Feb; 88(2):160-4. PMID: 10644483.
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    174. Hines OJ, Whang EE, Bilchik AJ, Zinner MJ, Welton ML, Lane J, McFadden DW, Ashley SW. Role of Na+-glucose cotransport in jejunal meal-induced absorption. Dig Dis Sci. 2000 Jan; 45(1):1-6. PMID: 10695605.
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    175. Maggard MA, Thompson JE, Schmit PJ, Chandler CF, Bennion RS, Au A, Hines OJ. Same admission colon resection with primary anastomosis for acute diverticulitis. Am Surg. 1999 Oct; 65(10):927-30. PMID: 10515536.
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    176. Thakur A, Hines OJ, Thakur V, Gordon HE. Tumoral calcinosis regression after subtotal parathyroidectomy: a case presentation and review of the literature. Surgery. 1999 Jul; 126(1):95-8. PMID: 10418601.
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    177. Lane JS, Whang EE, Rigberg DA, Hines OJ, Kwan D, Zinner MJ, McFadden DW, Diamond J, Ashley SW. Paracellular glucose transport plays a minor role in the unanesthetized dog. Am J Physiol. 1999 Mar; 276(3 Pt 1):G789-94. PMID: 10070058.
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    178. Hines OJ, Nelson S, Quinones-Baldrich WJ, Eilber FR. Leiomyosarcoma of the inferior vena cava: prognosis and comparison with leiomyosarcoma of other anatomic sites. Cancer. 1999 Mar 01; 85(5):1077-83. PMID: 10091791.
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    179. Hines OJ, Gordon HE. Secondary hyperparathyroidism in a patient with eight parathyroid glands. J Clin Endocrinol Metab. 1998 Jul; 83(7):2384-6. PMID: 9661614.
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    180. Whang EE, Hines OJ, Reeve JR, Grandt D, Moser JA, Bilchik AJ, Zinner MJ, McFadden DW, Ashley SW. Antisecretory mechanisms of peptide YY in rat distal colon. Dig Dis Sci. 1997 Jun; 42(6):1121-7. PMID: 9201071.
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    181. Patel AG, McFadden DW, Hines OJ, Reber HA, Ashley SW. Palliation for pancreatic cancer. Feasibility of laparoscopic cholecystojejunostomy and gastrojejunostomy in a porcine model. Surg Endosc. 1996 Jun; 10(6):639-43. PMID: 8662403.
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    182. Moyle H, Hines OJ, McFadden DW. Gossypiboma of the abdomen. Arch Surg. 1996 May; 131(5):566-8. PMID: 8624207.
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    183. Liu CD, Hines OJ, Newton TR, Adrian TE, Zinner MJ, Ashley SW, McFadden DW. Cholecystokinin mediation of colonic absorption via peptide YY: foregut-hindgut axis. World J Surg. 1996 Feb; 20(2):221-7. PMID: 8661821.
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    184. Liu CD, Hines OJ, Whang EE, Balasubramaniam A, Newton TR, Zinner MJ, Ashley SW, McFadden DW. A novel synthetic analog of peptide YY, BIM-43004, given intraluminally, is proabsorptive. J Surg Res. 1995 Jul; 59(1):80-4. PMID: 7630141.
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