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Butler Peter

TitleProfessor
InstitutionUniversity of California Los Angeles
DepartmentMedicine
Address200 UCLA Med Plaza
Los Angeles CA 90095
Phone310-206-7312
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    Collapse Research 
    Collapse Research Activities and Funding
    Capacity and Mechanisms of Beta Cell Regeneration in Humans
    NIH/NIDDK R01DK077967Apr 1, 2007 - Jun 30, 2017
    Role: Principal Investigator
    Role of Pulsatile Insulin Secretion
    NIH/NIDDK R01DK061539Jul 1, 2002 - May 31, 2014
    Role: Principal Investigator
    Role of IAPP in Islet Dysfunction in Diabetes
    NIH/NIDDK R01DK059579Jun 1, 2001 - Jan 31, 2020
    Role: Principal Investigator
    PULSATILE INSULIN SECRETION ON INSULIN ACTION
    NIH/NIDDK R29DK044341Sep 1, 1991 - Aug 31, 1996
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Wei Q, Huang C, Zhang Y, Zhao T, Zhao P, Butler P, Zhang S. Mechanotargeting: Mechanics-Dependent Cellular Uptake of Nanoparticles. Adv Mater. 2018 May 23; e1707464. PMID: 29797358.
      View in: PubMed
    2. Ruiz L, Gurlo T, Ravier MA, Wojtusciszyn A, Mathieu J, Brown MR, Broca C, Bertrand G, Butler P, Matveyenko AV, Dalle S, Costes S. Proteasomal degradation of the histone acetyl transferase p300 contributes to beta-cell injury in a diabetes environment. Cell Death Dis. 2018 May 22; 9(6):600. PMID: 29789539.
      View in: PubMed
    3. Moin ASM, Cory M, Choi J, Ong A, Dhawan S, Dry SM, Butler P, Rizza R, Butler A. Increased Chromogranin A-positive Hormone Negative Cells in Chronic Pancreatitis. J Clin Endocrinol Metab. 2018 Apr 05. PMID: 29659906.
      View in: PubMed
    4. Montemurro C, Vadrevu S, Gurlo T, Butler AE, Vongbunyong KE, Petcherski A, Shirihai OS, Satin LS, Braas D, Butler P, Tudzarova S. Cell cycle-related metabolism and mitochondrial dynamics in a replication-competent pancreatic beta-cell line. Cell Cycle. 2017; 16(21):2086-2099. PMID: 28820316.
      View in: PubMed
    5. Schludi B, Moin ASM, Montemurro C, Gurlo T, Matveyenko AV, Kirakossian D, Dawson DW, Dry SM, Butler P, Butler AE. Islet inflammation and ductal proliferation may be linked to increased pancreatitis risk in type 2 diabetes. JCI Insight. 2017 Jul 06; 2(13). PMID: 28679961.
      View in: PubMed
    6. Md Moin AS, Cory M, Ong A, Choi J, Dhawan S, Butler P, Butler AE. Pancreatic Nonhormone Expressing Endocrine Cells in Children With Type 1 Diabetes. J Endocr Soc. 2017 May 01; 1(5):385-395. PMID: 28782056.
      View in: PubMed
    7. Butler AE, Sacks W, Rizza RA, Butler P. Down Syndrome-Associated Diabetes Is Not Due To a Congenital Deficiency in ß Cells. J Endocr Soc. 2017 Jan 01; 1(1):39-45. PMID: 28782055.
      View in: PubMed
    8. Moin AS, Butler P, Butler AE. Increased Proliferation of the Pancreatic Duct Gland Compartment in Type 1 Diabetes. J Clin Endocrinol Metab. 2017 01 01; 102(1):200-209. PMID: 27813705.
      View in: PubMed
    9. Gurlo T, Costes S, Hoang JD, Rivera JF, Butler AE, Butler P. ß Cell-specific increased expression of calpastatin prevents diabetes induced by islet amyloid polypeptide toxicity. JCI Insight. 2016 Nov 03; 1(18):e89590. PMID: 27812546.
      View in: PubMed
    10. Butler P. Glucagon-like Peptide 1 Drugs as Second-line Therapy for Type 2 Diabetes. JAMA Intern Med. 2016 Oct 01; 176(10):1-3. PMID: 27479247.
      View in: PubMed
    11. Md Moin AS, Dhawan S, Cory M, Butler P, Rizza RA, Butler AE. Increased Frequency of Hormone Negative and Polyhormonal Endocrine Cells in Lean Individuals With Type 2 Diabetes. J Clin Endocrinol Metab. 2016 10; 101(10):3628-3636. PMID: 27472443.
      View in: PubMed
    12. Md Moin AS, Dhawan S, Shieh C, Butler P, Cory M, Butler AE. Increased Hormone-Negative Endocrine Cells in the Pancreas in Type 1 Diabetes. J Clin Endocrinol Metab. 2016 09; 101(9):3487-96. PMID: 27300574.
      View in: PubMed
    13. Butler AE, Matveyenko AV, Kirakossian D, Park J, Gurlo T, Butler P. Recovery of high-quality RNA from laser capture microdissected human and rodent pancreas. J Histotechnol. 2016; 39(2):59-65. PMID: 27231405.
      View in: PubMed
    14. Gurlo T, Butler P, Butler AE. Evaluation of immunohistochemical staining for glucagon in human pancreatic tissue. J Histotechnol. 2016; 39(1):8-16. PMID: 27182095.
      View in: PubMed
    15. Gurlo T, Rivera JF, Butler AE, Cory M, Hoang J, Costes S, Butler P. CHOP Contributes to, But Is Not the Only Mediator of, IAPP Induced ß-Cell Apoptosis. Mol Endocrinol. 2016 Apr; 30(4):446-54. PMID: 26900721; PMCID: PMC4814476 [Available on 04/01/17].
    16. Butler AE, Dhawan S, Hoang J, Cory M, Zeng K, Fritsch H, Meier JJ, Rizza RA, Butler P. ß-Cell Deficit in Obese Type 2 Diabetes, a Minor Role of ß-Cell Dedifferentiation and Degranulation. J Clin Endocrinol Metab. 2016 Feb; 101(2):523-32. PMID: 26700560; PMCID: PMC4880126 [Available on 02/01/17].
    17. Kegulian NC, Sankhagowit S, Apostolidou M, Jayasinghe SA, Malmstadt N, Butler P, Langen R. Membrane Curvature-sensing and Curvature-inducing Activity of Islet Amyloid Polypeptide and Its Implications for Membrane Disruption. J Biol Chem. 2015 Oct 23; 290(43):25782-93. PMID: 26283787; PMCID: PMC4646232 [Available on 10/23/16].
    18. Mukherjee A, Morales-Scheihing D, Butler P, Soto C. Type 2 diabetes as a protein misfolding disease. Trends Mol Med. 2015 Jul; 21(7):439-49. PMID: 25998900; PMCID: PMC4492843.
    19. Ramasamy R, Chiba K, Butler P, Lamb DJ. Male biological clock: a critical analysis of advanced paternal age. Fertil Steril. 2015 Jun; 103(6):1402-6. PMID: 25881878; PMCID: PMC4955707.
    20. Satin LS, Butler P, Ha J, Sherman AS. Pulsatile insulin secretion, impaired glucose tolerance and type 2 diabetes. Mol Aspects Med. 2015 Apr; 42:61-77. PMID: 25637831; PMCID: PMC4696552.
    21. Costes S, Butler P. Insulin-degrading enzyme inhibition, a novel therapy for type 2 diabetes? Cell Metab. 2014 Aug 05; 20(2):201-3. PMID: 25100059; PMCID: PMC4144405.
    22. Rivera JF, Costes S, Gurlo T, Glabe CG, Butler P. Autophagy defends pancreatic ß cells from human islet amyloid polypeptide-induced toxicity. J Clin Invest. 2014 Aug; 124(8):3489-500. PMID: 25036708; PMCID: PMC4109537.
    23. Costes S, Gurlo T, Rivera JF, Butler P. UCHL1 deficiency exacerbates human islet amyloid polypeptide toxicity in ß-cells: evidence of interplay between the ubiquitin/proteasome system and autophagy. Autophagy. 2014 Jun; 10(6):1004-14. PMID: 24879150; PMCID: PMC4091165.
    24. Butler AE, Campbell-Thompson M, Gurlo T, Dawson DW, Atkinson M, Butler P. Response to comments on: Butler et al. Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors. Diabetes 2013;62:2595-2604. Diabetes. 2013 Oct; 62(10):e19-22. PMID: 24065800; PMCID: PMC3781463.
    25. Saisho Y, Butler AE, Manesso E, Butler P. Response to Comment on: Saisho et al. ß-cell mass and turnover in humans: effects of obesity and aging. Diabetes Care 2013;36:111-117. Diabetes Care. 2013 Jul; 36(7):e112. PMID: 23801813; PMCID: PMC3687307.
    26. Butler P, Elashoff M, Elashoff R, Gale EA. A critical analysis of the clinical use of incretin-based therapies: Are the GLP-1 therapies safe? Diabetes Care. 2013 Jul; 36(7):2118-25. PMID: 23645885; PMCID: PMC3687282.
    27. Gier B, Butler P. Glucagonlike Peptide 1-based drugs and pancreatitis: clarity at last, but what about pancreatic cancer? JAMA Intern Med. 2013 Apr 08; 173(7):539-41. PMID: 23463371.
      View in: PubMed
    28. Butler AE, Campbell-Thompson M, Gurlo T, Dawson DW, Atkinson M, Butler P. Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors. Diabetes. 2013 Jul; 62(7):2595-604. PMID: 23524641; PMCID: PMC3712065.
    29. Costes S, Langen R, Gurlo T, Matveyenko AV, Butler P. ß-Cell failure in type 2 diabetes: a case of asking too much of too few? Diabetes. 2013 Feb; 62(2):327-35. PMID: 23349537; PMCID: PMC3554362.
    30. Saisho Y, Butler AE, Manesso E, Elashoff D, Rizza RA, Butler P. ß-cell mass and turnover in humans: effects of obesity and aging. Diabetes Care. 2013 Jan; 36(1):111-7. PMID: 22875233; PMCID: PMC3526241.
    31. Matveyenko AV, Liuwantara D, Gurlo T, Kirakossian D, Dalla Man C, Cobelli C, White MF, Copps KD, Volpi E, Fujita S, Butler P. Pulsatile portal vein insulin delivery enhances hepatic insulin action and signaling. Diabetes. 2012 Sep; 61(9):2269-79. PMID: 22688333; PMCID: PMC3425431.
    32. Gier B, Matveyenko AV, Kirakossian D, Dawson D, Dry SM, Butler P. Chronic GLP-1 receptor activation by exendin-4 induces expansion of pancreatic duct glands in rats and accelerates formation of dysplastic lesions and chronic pancreatitis in the Kras(G12D) mouse model. Diabetes. 2012 May; 61(5):1250-62. PMID: 22266668; PMCID: PMC3331736.
    33. Butler P. Farewell statement from Dr. Peter Butler as outgoing editor in chief of diabetes. Diabetes. 2011 Dec; 60(12):3099. PMID: 22110090; PMCID: PMC3219941.
    34. Gier B, Butler P, Lai CK, Kirakossian D, DeNicola MM, Yeh MW. Glucagon like peptide-1 receptor expression in the human thyroid gland. J Clin Endocrinol Metab. 2012 Jan; 97(1):121-31. PMID: 22031513; PMCID: PMC3412261.
    35. Sdek P, Zhao P, Wang Y, Huang CJ, Ko CY, Butler P, Weiss JN, Maclellan WR. Rb and p130 control cell cycle gene silencing to maintain the postmitotic phenotype in cardiac myocytes. J Cell Biol. 2011 Aug 08; 194(3):407-23. PMID: 21825075; PMCID: PMC3153646.
    36. Schneeberger S, Landin L, Jableki J, Butler P, Hoehnke C, Brandacher G, Morelon E. Achievements and challenges in composite tissue allotransplantation. Transpl Int. 2011 Aug; 24(8):760-9. PMID: 21554424.
      View in: PubMed
    37. Daval M, Gurlo T, Costes S, Huang CJ, Butler P. Cyclin-dependent kinase 5 promotes pancreatic ß-cell survival via Fak-Akt signaling pathways. Diabetes. 2011 Apr; 60(4):1186-97. PMID: 21378178; PMCID: PMC3064092.
    38. Manesso E, Toffolo GM, Butler AE, Butler P, Cobelli C. Shortened {beta}-cell lifespan leads to {beta}-cell deficit in a rodent model of type 2 diabetes. Am J Physiol Endocrinol Metab. 2011 May; 300(5):E933-8. PMID: 21343541; PMCID: PMC3279301.
    39. Elashoff M, Matveyenko AV, Gier B, Elashoff R, Butler P. Pancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapies. Gastroenterology. 2011 Jul; 141(1):150-6. PMID: 21334333; PMCID: PMC4404515.
    40. Saisho Y, Manesso E, Butler AE, Galasso R, Kavanagh K, Flynn M, Zhang L, Clark P, Gurlo T, Toffolo GM, Cobelli C, Wagner JD, Butler P. Ongoing beta-cell turnover in adult nonhuman primates is not adaptively increased in streptozotocin-induced diabetes. Diabetes. 2011 Mar; 60(3):848-56. PMID: 21270238; PMCID: PMC3046845.
    41. Daval M, Bedrood S, Gurlo T, Huang CJ, Costes S, Butler P, Langen R. The effect of curcumin on human islet amyloid polypeptide misfolding and toxicity. Amyloid. 2010 Sep; 17(3-4):118-28. PMID: 21067307; PMCID: PMC4394664.
    42. Costes S, Huang CJ, Gurlo T, Daval M, Matveyenko AV, Rizza RA, Butler AE, Butler P. ß-cell dysfunctional ERAD/ubiquitin/proteasome system in type 2 diabetes mediated by islet amyloid polypeptide-induced UCH-L1 deficiency. Diabetes. 2011 Jan; 60(1):227-38. PMID: 20980462; PMCID: PMC3012175.
    43. Ritzel RA, Jayasinghe S, Hansen JB, Sturis J, Langen R, Butler P. Beta-cell selective K(ATP)-channel activation protects beta-cells and human islets from human islet amyloid polypeptide induced toxicity. Regul Pept. 2010 Dec 10; 165(2-3):158-62. PMID: 20619299; PMCID: PMC2995001.
    44. Matveyenko AV, Georgia S, Bhushan A, Butler P. Inconsistent formation and nonfunction of insulin-positive cells from pancreatic endoderm derived from human embryonic stem cells in athymic nude rats. Am J Physiol Endocrinol Metab. 2010 Nov; 299(5):E713-20. PMID: 20587750; PMCID: PMC3774125.
    45. Butler P, Dry S, Elashoff R. GLP-1-based therapy for diabetes: what you do not know can hurt you. Diabetes Care. 2010 Feb; 33(2):453-5. PMID: 20103562; PMCID: PMC2809301.
    46. Gurlo T, Ryazantsev S, Huang CJ, Yeh MW, Reber HA, Hines OJ, O'Brien TD, Glabe CG, Butler P. Evidence for proteotoxicity in beta cells in type 2 diabetes: toxic islet amyloid polypeptide oligomers form intracellularly in the secretory pathway. Am J Pathol. 2010 Feb; 176(2):861-9. PMID: 20042670; PMCID: PMC2808091.
    47. Bedrood S, Jayasinghe S, Sieburth D, Chen M, Erbel S, Butler P, Langen R, Ritzel RA. Annexin A5 directly interacts with amyloidogenic proteins and reduces their toxicity. Biochemistry. 2009 Nov 10; 48(44):10568-76. PMID: 19810772; PMCID: PMC4394648.
    48. Butler P, Matveyenko AV, Dry S, Bhushan A, Elashoff R. Glucagon-like peptide-1 therapy and the exocrine pancreas: innocent bystander or friendly fire? Diabetologia. 2010 Jan; 53(1):1-6. PMID: 19894028.
      View in: PubMed
    49. Butler P. Insulin glargine controversy: a tribute to the editorial team at Diabetologia. Diabetes. 2009 Nov; 58(11):2427-8. PMID: 19875618; PMCID: PMC2768168.
    50. Huang CJ, Gurlo T, Haataja L, Costes S, Daval M, Ryazantsev S, Wu X, Butler AE, Butler P. Calcium-activated calpain-2 is a mediator of beta cell dysfunction and apoptosis in type 2 diabetes. J Biol Chem. 2010 Jan 01; 285(1):339-48. PMID: 19861418; PMCID: PMC2804181.
    51. Manesso E, Toffolo GM, Saisho Y, Butler AE, Matveyenko AV, Cobelli C, Butler P. Dynamics of beta-cell turnover: evidence for beta-cell turnover and regeneration from sources of beta-cells other than beta-cell replication in the HIP rat. Am J Physiol Endocrinol Metab. 2009 Aug; 297(2):E323-30. PMID: 19470833; PMCID: PMC2724115.
    52. Matveyenko AV, Dry S, Cox HI, Moshtaghian A, Gurlo T, Galasso R, Butler AE, Butler P. Beneficial endocrine but adverse exocrine effects of sitagliptin in the human islet amyloid polypeptide transgenic rat model of type 2 diabetes: interactions with metformin. Diabetes. 2009 Jul; 58(7):1604-15. PMID: 19403868; PMCID: PMC2699878.
    53. Goland R, Freeby M, Parsey R, Saisho Y, Kumar D, Simpson N, Hirsch J, Prince M, Maffei A, Mann JJ, Butler P, Van Heertum R, Leibel RL, Ichise M, Harris PE. 11C-dihydrotetrabenazine PET of the pancreas in subjects with long-standing type 1 diabetes and in healthy controls. J Nucl Med. 2009 Mar; 50(3):382-9. PMID: 19223416; PMCID: PMC3629294.
    54. Matveyenko AV, Gurlo T, Daval M, Butler AE, Butler P. Successful versus failed adaptation to high-fat diet-induced insulin resistance: the role of IAPP-induced beta-cell endoplasmic reticulum stress. Diabetes. 2009 Apr; 58(4):906-16. PMID: 19151199; PMCID: PMC2661593.
    55. Saisho Y, Manesso E, Gurlo T, Huang CJ, Toffolo GM, Cobelli C, Butler P. Development of factors to convert frequency to rate for beta-cell replication and apoptosis quantified by time-lapse video microscopy and immunohistochemistry. Am J Physiol Endocrinol Metab. 2009 Jan; 296(1):E89-96. PMID: 18940937; PMCID: PMC4043232.
    56. Saisho Y, Harris PE, Butler AE, Galasso R, Gurlo T, Rizza RA, Butler P. Relationship between pancreatic vesicular monoamine transporter 2 (VMAT2) and insulin expression in human pancreas. J Mol Histol. 2008 Oct; 39(5):543-51. PMID: 18791800; PMCID: PMC2566800.
    57. Matveyenko AV, Veldhuis JD, Butler P. Adaptations in pulsatile insulin secretion, hepatic insulin clearance, and beta-cell mass to age-related insulin resistance in rats. Am J Physiol Endocrinol Metab. 2008 Oct; 295(4):E832-41. PMID: 18664594; PMCID: PMC2575907.
    58. Haataja L, Gurlo T, Huang CJ, Butler P. Many commercially available antibodies for detection of CHOP expression as a marker of endoplasmic reticulum stress fail specificity evaluation. Cell Biochem Biophys. 2008; 51(2-3):105-7. PMID: 18651105; PMCID: PMC2527405.
    59. Matveyenko AV, Veldhuis JD, Butler P. Measurement of pulsatile insulin secretion in the rat: direct sampling from the hepatic portal vein. Am J Physiol Endocrinol Metab. 2008 Sep; 295(3):E569-74. PMID: 18577690; PMCID: PMC2536733.
    60. Saisho Y, Butler AE, Butler P. Pancreatic fat content and beta-cell function in men with and without type 2 diabetes: response to Tushuizen et al. Diabetes Care. 2008 May; 31(5):e38; author reply e39. PMID: 18445718.
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    61. Meier JJ, Butler AE, Saisho Y, Monchamp T, Galasso R, Bhushan A, Rizza RA, Butler P. Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans. Diabetes. 2008 Jun; 57(6):1584-94. PMID: 18334605; PMCID: PMC3697779.
    62. Haataja L, Gurlo T, Huang CJ, Butler P. Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis. Endocr Rev. 2008 May; 29(3):303-16. PMID: 18314421; PMCID: PMC2528855.
    63. Butler P, Meier JJ, Butler AE, Bhushan A. The replication of beta cells in normal physiology, in disease and for therapy. Nat Clin Pract Endocrinol Metab. 2007 Nov; 3(11):758-68. PMID: 17955017.
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    64. Huang CJ, Haataja L, Gurlo T, Butler AE, Wu X, Soeller WC, Butler P. Induction of endoplasmic reticulum stress-induced beta-cell apoptosis and accumulation of polyubiquitinated proteins by human islet amyloid polypeptide. Am J Physiol Endocrinol Metab. 2007 Dec; 293(6):E1656-62. PMID: 17911343.
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    65. Kayed R, Head E, Sarsoza F, Saing T, Cotman CW, Necula M, Margol L, Wu J, Breydo L, Thompson JL, Rasool S, Gurlo T, Butler P, Glabe CG. Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers. Mol Neurodegener. 2007 Sep 26; 2:18. PMID: 17897471; PMCID: PMC2100048.
    66. Huang CJ, Lin CY, Haataja L, Gurlo T, Butler AE, Rizza RA, Butler P. High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated beta-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes. Diabetes. 2007 Aug; 56(8):2016-27. PMID: 17475933.
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    67. Butler AE, Huang A, Rao PN, Bhushan A, Hogan WJ, Rizza RA, Butler P. Hematopoietic stem cells derived from adult donors are not a source of pancreatic beta-cells in adult nondiabetic humans. Diabetes. 2007 Jul; 56(7):1810-6. PMID: 17456852.
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    68. Lin CY, Gurlo T, Kayed R, Butler AE, Haataja L, Glabe CG, Butler P. Toxic human islet amyloid polypeptide (h-IAPP) oligomers are intracellular, and vaccination to induce anti-toxic oligomer antibodies does not prevent h-IAPP-induced beta-cell apoptosis in h-IAPP transgenic mice. Diabetes. 2007 May; 56(5):1324-32. PMID: 17353506.
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    69. Cobelli C, Toffolo GM, Dalla Man C, Campioni M, Denti P, Caumo A, Butler P, Rizza R. Assessment of beta-cell function in humans, simultaneously with insulin sensitivity and hepatic extraction, from intravenous and oral glucose tests. Am J Physiol Endocrinol Metab. 2007 Jul; 293(1):E1-E15. PMID: 17341552.
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    70. Ritzel RA, Meier JJ, Lin CY, Veldhuis JD, Butler P. Human islet amyloid polypeptide oligomers disrupt cell coupling, induce apoptosis, and impair insulin secretion in isolated human islets. Diabetes. 2007 Jan; 56(1):65-71. PMID: 17192466.
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    71. Meier JJ, Hong-McAtee I, Galasso R, Veldhuis JD, Moran A, Hering BJ, Butler P. Intrahepatic transplanted islets in humans secrete insulin in a coordinate pulsatile manner directly into the liver. Diabetes. 2006 Aug; 55(8):2324-32. PMID: 16873697.
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    72. Matveyenko AV, Veldhuis JD, Butler P. Mechanisms of impaired fasting glucose and glucose intolerance induced by an approximate 50% pancreatectomy. Diabetes. 2006 Aug; 55(8):2347-56. PMID: 16873700.
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    73. Meier JJ, Kayed R, Lin CY, Gurlo T, Haataja L, Jayasinghe S, Langen R, Glabe CG, Butler P. Inhibition of human IAPP fibril formation does not prevent beta-cell death: evidence for distinct actions of oligomers and fibrils of human IAPP. Am J Physiol Endocrinol Metab. 2006 Dec; 291(6):E1317-24. PMID: 16849627.
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    74. Matveyenko AV, Butler P. Beta-cell deficit due to increased apoptosis in the human islet amyloid polypeptide transgenic (HIP) rat recapitulates the metabolic defects present in type 2 diabetes. Diabetes. 2006 Jul; 55(7):2106-14. PMID: 16804082.
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    75. Meier JJ, Butler AE, Galasso R, Butler P. Hyperinsulinemic hypoglycemia after gastric bypass surgery is not accompanied by islet hyperplasia or increased beta-cell turnover. Diabetes Care. 2006 Jul; 29(7):1554-9. PMID: 16801578.
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    76. Meier JJ, Bhushan A, Butler P. The potential for stem cell therapy in diabetes. Pediatr Res. 2006 Apr; 59(4 Pt 2):65R-73R. PMID: 16549551.
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    77. Meier JJ, Kjems LL, Veldhuis JD, Lefèbvre P, Butler P. Postprandial suppression of glucagon secretion depends on intact pulsatile insulin secretion: further evidence for the intraislet insulin hypothesis. Diabetes. 2006 Apr; 55(4):1051-6. PMID: 16567528.
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    78. Ritzel RA, Butler AE, Rizza RA, Veldhuis JD, Butler P. Relationship between beta-cell mass and fasting blood glucose concentration in humans. Diabetes Care. 2006 Mar; 29(3):717-8. PMID: 16505537.
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    79. Matveyenko AV, Butler P. Islet amyloid polypeptide (IAPP) transgenic rodents as models for type 2 diabetes. ILAR J. 2006; 47(3):225-33. PMID: 16804197.
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    80. Lin CY, Gurlo T, Haataja L, Hsueh WA, Butler P. Activation of peroxisome proliferator-activated receptor-gamma by rosiglitazone protects human islet cells against human islet amyloid polypeptide toxicity by a phosphatidylinositol 3'-kinase-dependent pathway. J Clin Endocrinol Metab. 2005 Dec; 90(12):6678-86. PMID: 16204373.
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    81. Meier JJ, Veldhuis JD, Butler P. Pulsatile insulin secretion dictates systemic insulin delivery by regulating hepatic insulin extraction in humans. Diabetes. 2005 Jun; 54(6):1649-56. PMID: 15919785.
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    82. Butler AE, Jang J, Gurlo T, Carty MD, Soeller WC, Butler P. Diabetes due to a progressive defect in beta-cell mass in rats transgenic for human islet amyloid polypeptide (HIP Rat): a new model for type 2 diabetes. Diabetes. 2004 Jun; 53(6):1509-16. PMID: 15161755.
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    83. Janson J, Laedtke T, Parisi JE, O'Brien P, Petersen RC, Butler P. Increased risk of type 2 diabetes in Alzheimer disease. Diabetes. 2004 Feb; 53(2):474-81. PMID: 14747300.
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    84. Ritzel RA, Hansen JB, Veldhuis JD, Butler P. Induction of beta-cell rest by a Kir6.2/SUR1-selective K(ATP)-channel opener preserves beta-cell insulin stores and insulin secretion in human islets cultured at high (11 mM) glucose. J Clin Endocrinol Metab. 2004 Feb; 89(2):795-805. PMID: 14764798.
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    85. Butler AE, Janson J, Soeller WC, Butler P. Increased beta-cell apoptosis prevents adaptive increase in beta-cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid. Diabetes. 2003 Sep; 52(9):2304-14. PMID: 12941770.
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    86. Song SH, Rhodes CJ, Veldhuis JD, Butler P. Diazoxide attenuates glucose-induced defects in first-phase insulin release and pulsatile insulin secretion in human islets. Endocrinology. 2003 Aug; 144(8):3399-405. PMID: 12865318.
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    87. Ritzel RA, Butler P. Replication increases beta-cell vulnerability to human islet amyloid polypeptide-induced apoptosis. Diabetes. 2003 Jul; 52(7):1701-8. PMID: 12829636.
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    88. Ritzel RA, Veldhuis JD, Butler P. Glucose stimulates pulsatile insulin secretion from human pancreatic islets by increasing secretory burst mass: dose-response relationships. J Clin Endocrinol Metab. 2003 Feb; 88(2):742-7. PMID: 12574208.
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    89. Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler P. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes. 2003 Jan; 52(1):102-10. PMID: 12502499.
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    90. Pørksen N, Hollingdal M, Juhl C, Butler P, Veldhuis JD, Schmitz O. Pulsatile insulin secretion: detection, regulation, and role in diabetes. Diabetes. 2002 Feb; 51 Suppl 1:S245-54. PMID: 11815487.
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    91. Juhl C, Grøfte T, Butler P, Veldhuis JD, Schmitz O, Pørksen N. Effects of fasting on physiologically pulsatile insulin release in healthy humans. Diabetes. 2002 Feb; 51 Suppl 1:S255-7. PMID: 11815488.
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    92. Song SH, Kjems L, Ritzel R, McIntyre SM, Johnson ML, Veldhuis JD, Butler P. Pulsatile insulin secretion by human pancreatic islets. J Clin Endocrinol Metab. 2002 Jan; 87(1):213-21. PMID: 11788649.
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