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Liu Philip

Title(s)Assistant Professor, Orthopaedic Surgery
SchoolLABioMed
Phone310-206-8457
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    Collapse Research 
    Collapse Research Activities and Funding
    Mechanism of retinoic acid receptor induced innate immune responses
    NIH/NIAID K22AI085025Aug 4, 2010 - Jul 31, 2012
    Role: Principal Investigator
    Role of Vitamin D Prohormone 25-OHD in the Immune Response to Tuberculosis
    NIH/NHLBI R01HL119068Jun 1, 2008 - Jun 30, 2018
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Kim EW, De Leon A, Jiang Z, Radu RA, Martineau AR, Chan ED, Bai X, Su WL, Montoya DJ, Modlin RL, Liu PT. Vitamin A Metabolism by Dendritic Cells Triggers an Antimicrobial Response against Mycobacterium tuberculosis. mSphere. 2019 Jun 05; 4(3). PMID: 31167948.
      View in: PubMed
    2. Zavala K, Gottlieb CA, Teles RM, Adams JS, Hewison M, Modlin RL, Liu PT. Intrinsic activation of the vitamin D antimicrobial pathway by M. leprae infection is inhibited by type I IFN. PLoS Negl Trop Dis. 2018 10; 12(10):e0006815. PMID: 30300363.
      View in: PubMed
    3. Kim EW, Teles RMB, Haile S, Liu PT, Modlin RL. Vitamin D status contributes to the antimicrobial activity of macrophages against Mycobacterium leprae. PLoS Negl Trop Dis. 2018 07; 12(7):e0006608. PMID: 29965969.
      View in: PubMed
    4. Park AJ, Agak GW, Qin M, Hisaw LD, Pirouz A, Kao S, Marinelli LJ, Garbán HJ, Thiboutot D, Liu PT, Kim J. G2A Attenuates Propionibacterium acnes Induction of Inflammatory Cytokines in Human Monocytes. Ann Dermatol. 2017 Dec; 29(6):688-698. PMID: 29200756.
      View in: PubMed
    5. Realegeno S, Kelly-Scumpia KM, Dang AT, Lu J, Teles R, Liu PT, Schenk M, Lee EY, Schmidt NW, Wong GC, Sarno EN, Rea TH, Ochoa MT, Pellegrini M, Modlin RL. S100A12 Is Part of the Antimicrobial Network against Mycobacterium leprae in Human Macrophages. PLoS Pathog. 2016 06; 12(6):e1005705. PMID: 27355424.
      View in: PubMed
    6. Kim EW, Nadipuram SM, Tetlow AL, Barshop WD, Liu PT, Wohlschlegel JA, Bradley PJ. The Rhoptry Pseudokinase ROP54 Modulates Toxoplasma gondii Virulence and Host GBP2 Loading. mSphere. 2016 Mar-Apr; 1(2). PMID: 27303719.
      View in: PubMed
    7. Mehta MD, Liu PT. microRNAs in mycobacterial disease: friend or foe? Front Genet. 2014; 5:231. PMID: 25076967.
      View in: PubMed
    8. Chun RF, Liu PT, Modlin RL, Adams JS, Hewison M. Impact of vitamin D on immune function: lessons learned from genome-wide analysis. Front Physiol. 2014; 5:151. PMID: 24795646.
      View in: PubMed
    9. Wheelwright M, Kim EW, Inkeles MS, De Leon A, Pellegrini M, Krutzik SR, Liu PT. All-trans retinoic acid-triggered antimicrobial activity against Mycobacterium tuberculosis is dependent on NPC2. J Immunol. 2014 Mar 01; 192(5):2280-2290. PMID: 24501203.
      View in: PubMed
    10. Schenk M, Fabri M, Krutzik SR, Lee DJ, Vu DM, Sieling PA, Montoya D, Liu PT, Modlin RL. Interleukin-1ß triggers the differentiation of macrophages with enhanced capacity to present mycobacterial antigen to T cells. Immunology. 2014 Feb; 141(2):174-80. PMID: 24032597.
      View in: PubMed
    11. Adams JS, Rafison B, Witzel S, Reyes RE, Shieh A, Chun R, Zavala K, Hewison M, Liu PT. Regulation of the extrarenal CYP27B1-hydroxylase. J Steroid Biochem Mol Biol. 2014 Oct; 144 Pt A:22-7. PMID: 24388948.
      View in: PubMed
    12. Klug-Micu GM, Stenger S, Sommer A, Liu PT, Krutzik SR, Modlin RL, Fabri M. CD40 ligand and interferon-? induce an antimicrobial response against Mycobacterium tuberculosis in human monocytes. Immunology. 2013 May; 139(1):121-8. PMID: 23289765.
      View in: PubMed
    13. Adams JS, Ramin J, Rafison B, Windon C, Windon A, Liu PT. Redefining Human Vitamin D Sufficiency: Back to the Basics. Bone Res. 2013; 1(1):2-10. PMID: 25285234.
      View in: PubMed
    14. Friedman AJ, Phan J, Schairer DO, Champer J, Qin M, Pirouz A, Blecher-Paz K, Oren A, Liu PT, Modlin RL, Kim J. Antimicrobial and anti-inflammatory activity of chitosan-alginate nanoparticles: a targeted therapy for cutaneous pathogens. J Invest Dermatol. 2013 May; 133(5):1231-9. PMID: 23190896.
      View in: PubMed
    15. Liu PT, Wheelwright M, Teles R, Komisopoulou E, Edfeldt K, Ferguson B, Mehta MD, Vazirnia A, Rea TH, Sarno EN, Graeber TG, Modlin RL. MicroRNA-21 targets the vitamin D-dependent antimicrobial pathway in leprosy. Nat Med. 2012 Jan 29; 18(2):267-73. PMID: 22286305.
      View in: PubMed
    16. Fabri M, Stenger S, Shin DM, Yuk JM, Liu PT, Realegeno S, Lee HM, Krutzik SR, Schenk M, Sieling PA, Teles R, Montoya D, Iyer SS, Bruns H, Lewinsohn DM, Hollis BW, Hewison M, Adams JS, Steinmeyer A, Zügel U, Cheng G, Jo EK, Bloom BR, Modlin RL. Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages. Sci Transl Med. 2011 Oct 12; 3(104):104ra102. PMID: 21998409.
      View in: PubMed
    17. Walker VP, Zhang X, Rastegar I, Liu PT, Hollis BW, Adams JS, Modlin RL. Cord blood vitamin D status impacts innate immune responses. J Clin Endocrinol Metab. 2011 Jun; 96(6):1835-43. PMID: 21470993.
      View in: PubMed
    18. Edfeldt K, Liu PT, Chun R, Fabri M, Schenk M, Wheelwright M, Keegan C, Krutzik SR, Adams JS, Hewison M, Modlin RL. T-cell cytokines differentially control human monocyte antimicrobial responses by regulating vitamin D metabolism. Proc Natl Acad Sci U S A. 2010 Dec 28; 107(52):22593-8. PMID: 21149724.
      View in: PubMed
    19. Fiala M, Chattopadhay M, La Cava A, Tse E, Liu G, Lourenco E, Eskin A, Liu PT, Magpantay L, Tse S, Mahanian M, Weitzman R, Tong J, Nguyen C, Cho T, Koo P, Sayre J, Martinez-Maza O, Rosenthal MJ, Wiedau-Pazos M. IL-17A is increased in the serum and in spinal cord CD8 and mast cells of ALS patients. J Neuroinflammation. 2010 Nov 09; 7:76. PMID: 21062492.
      View in: PubMed
    20. Liu PT, Schenk M, Walker VP, Dempsey PW, Kanchanapoomi M, Wheelwright M, Vazirnia A, Zhang X, Steinmeyer A, Zügel U, Hollis BW, Cheng G, Modlin RL. Convergence of IL-1beta and VDR activation pathways in human TLR2/1-induced antimicrobial responses. PLoS One. 2009 Jun 05; 4(6):e5810. PMID: 19503839.
      View in: PubMed
    21. Adams JS, Ren S, Liu PT, Chun RF, Lagishetty V, Gombart AF, Borregaard N, Modlin RL, Hewison M. Vitamin d-directed rheostatic regulation of monocyte antibacterial responses. J Immunol. 2009 Apr 01; 182(7):4289-95. PMID: 19299728.
      View in: PubMed
    22. Avagyan H, Goldenson B, Tse E, Masoumi A, Porter V, Wiedau-Pazos M, Sayre J, Ong R, Mahanian M, Koo P, Bae S, Micic M, Liu PT, Rosenthal MJ, Fiala M. Immune blood biomarkers of Alzheimer disease patients. J Neuroimmunol. 2009 May 29; 210(1-2):67-72. PMID: 19329192.
      View in: PubMed
    23. Krutzik SR, Hewison M, Liu PT, Robles JA, Stenger S, Adams JS, Modlin RL. IL-15 links TLR2/1-induced macrophage differentiation to the vitamin D-dependent antimicrobial pathway. J Immunol. 2008 Nov 15; 181(10):7115-20. PMID: 18981132.
      View in: PubMed
    24. Liu PT, Modlin RL. Human macrophage host defense against Mycobacterium tuberculosis. Curr Opin Immunol. 2008 Aug; 20(4):371-6. PMID: 18602003.
      View in: PubMed
    25. Jalian HR, Liu PT, Kanchanapoomi M, Phan JN, Legaspi AJ, Kim J. All-trans retinoic acid shifts Propionibacterium acnes-induced matrix degradation expression profile toward matrix preservation in human monocytes. J Invest Dermatol. 2008 Dec; 128(12):2777-82. PMID: 18563181.
      View in: PubMed
    26. Liu PT, Phan J, Tang D, Kanchanapoomi M, Hall B, Krutzik SR, Kim J. CD209(+) macrophages mediate host defense against Propionibacterium acnes. J Immunol. 2008 Apr 01; 180(7):4919-23. PMID: 18354216.
      View in: PubMed
    27. Liu PT, Stenger S, Tang DH, Modlin RL. Cutting edge: vitamin D-mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin. J Immunol. 2007 Aug 15; 179(4):2060-3. PMID: 17675463.
      View in: PubMed
    28. Adams JS, Liu PT, Chun R, Modlin RL, Hewison M. Vitamin D in defense of the human immune response. Ann N Y Acad Sci. 2007 Nov; 1117:94-105. PMID: 17656563.
      View in: PubMed
    29. Fiala M, Liu PT, Espinosa-Jeffrey A, Rosenthal MJ, Bernard G, Ringman JM, Sayre J, Zhang L, Zaghi J, Dejbakhsh S, Chiang B, Hui J, Mahanian M, Baghaee A, Hong P, Cashman J. Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer's disease patients are improved by bisdemethoxycurcumin. Proc Natl Acad Sci U S A. 2007 Jul 31; 104(31):12849-54. PMID: 17652175.
      View in: PubMed
    30. Schauber J, Dorschner RA, Coda AB, Büchau AS, Liu PT, Kiken D, Helfrich YR, Kang S, Elalieh HZ, Steinmeyer A, Zügel U, Bikle DD, Modlin RL, Gallo RL. Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism. J Clin Invest. 2007 Mar; 117(3):803-11. PMID: 17290304.
      View in: PubMed
    31. Liu PT, Krutzik SR, Modlin RL. Therapeutic implications of the TLR and VDR partnership. Trends Mol Med. 2007 Mar; 13(3):117-24. PMID: 17276732.
      View in: PubMed
    32. Renn CN, Sanchez DJ, Ochoa MT, Legaspi AJ, Oh CK, Liu PT, Krutzik SR, Sieling PA, Cheng G, Modlin RL. TLR activation of Langerhans cell-like dendritic cells triggers an antiviral immune response. J Immunol. 2006 Jul 01; 177(1):298-305. PMID: 16785525.
      View in: PubMed
    33. Liu PT, Stenger S, Li H, Wenzel L, Tan BH, Krutzik SR, Ochoa MT, Schauber J, Wu K, Meinken C, Kamen DL, Wagner M, Bals R, Steinmeyer A, Zügel U, Gallo RL, Eisenberg D, Hewison M, Hollis BW, Adams JS, Bloom BR, Modlin RL. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science. 2006 Mar 24; 311(5768):1770-3. PMID: 16497887.
      View in: PubMed
    34. Miller LS, Sørensen OE, Liu PT, Jalian HR, Eshtiaghpour D, Behmanesh BE, Chung W, Starner TD, Kim J, Sieling PA, Ganz T, Modlin RL. TGF-alpha regulates TLR expression and function on epidermal keratinocytes. J Immunol. 2005 May 15; 174(10):6137-43. PMID: 15879109.
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    35. Krutzik SR, Tan B, Li H, Ochoa MT, Liu PT, Sharfstein SE, Graeber TG, Sieling PA, Liu YJ, Rea TH, Bloom BR, Modlin RL. TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells. Nat Med. 2005 Jun; 11(6):653-60. PMID: 15880118.
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    36. Liu PT, Krutzik SR, Kim J, Modlin RL. Cutting edge: all-trans retinoic acid down-regulates TLR2 expression and function. J Immunol. 2005 Mar 01; 174(5):2467-70. PMID: 15728448.
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    37. Doyle SE, O'Connell RM, Miranda GA, Vaidya SA, Chow EK, Liu PT, Suzuki S, Suzuki N, Modlin RL, Yeh WC, Lane TF, Cheng G. Toll-like receptors induce a phagocytic gene program through p38. J Exp Med. 2004 Jan 05; 199(1):81-90. PMID: 14699082.
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    38. Krutzik SR, Ochoa MT, Sieling PA, Uematsu S, Ng YW, Legaspi A, Liu PT, Cole ST, Godowski PJ, Maeda Y, Sarno EN, Norgard MV, Brennan PJ, Akira S, Rea TH, Modlin RL. Activation and regulation of Toll-like receptors 2 and 1 in human leprosy. Nat Med. 2003 May; 9(5):525-32. PMID: 12692544.
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