Sun Ren

Title(s)Professor, Molecular & Medical Pharmacology
Phone(310) 794-5557
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    Other Positions
    Title(s)Professor, Bioengineering

    Title(s)Senior Associate Dean of Graduate Studies, David Geffen School of Medicine at UCLA

    Title(s)Associate Vice Provost, International Institute

    Collapse Research 
    Collapse Research Activities and Funding
    Mechanism for anti-interferon functions of influenza virus
    NIH/NIAID R01AI143287Jun 20, 2019 - May 31, 2024
    Role: Principal Investigator
    Structure-guided development of chemical inhibitors against Kaposi?s sarcoma-associated herpesvirus (KSHV)
    NIH/NCI R21CA240154Mar 1, 2019 - Feb 28, 2021
    Role: Principal Investigator
    Atomic structure of Kaposi's sarcoma-associated herpesvirus capsid
    NIH/NIDCR R01DE025567Dec 1, 2015 - Nov 30, 2020
    Role: Co-Principal Investigator
    Innate Immune Responses and Vaccines Against Tumor-Associated Herpesviruses
    NIH/NCI P01CA177322Sep 19, 2014 - Aug 31, 2019
    Role: Principal Investigator
    Functional Profiles of Hepatitis C Virus Genome at Single Nucleotide Resolution
    NIH/NCI R21CA183615May 1, 2014 - Apr 30, 2016
    Role: Principal Investigator
    Fitness Profile of HIV-1 Genome with Host Cofactor Selection Pressure
    NIH/NIAID R21AI110261Feb 1, 2014 - Jan 31, 2016
    Role: Principal Investigator
    Develop a therapeutic vaccine approach by removing viral immune evasion
    NIH/NIDCR R01DE023591Sep 13, 2013 - Apr 30, 2018
    Role: Principal Investigator
    The 13th international Workshop on KSHV and Related Agents
    NIH/NCI R13CA153946Sep 23, 2010 - Aug 31, 2011
    Role: Principal Investigator
    Quantitative High-Resolution Genetic Profiling of a Gammaherpesvirus
    NIH/NIAID R21AI078133May 1, 2010 - Apr 30, 2012
    Role: Principal Investigator
    Immunogenicity and efficacy of genetically engineered gamma-herpesvirus vaccines
    NIH/NCI RC2CA148250Sep 30, 2009 - Aug 31, 2011
    Role: Co-Principal Investigator
    Deregulation of host functions and persistence of KSHV
    NIH/NIDCR P01DE019085May 10, 2008 - Apr 30, 2013
    Role: Principal Investigator
    Genome-wide identification of suppressors of KSHV reactivation
    NIH/NCI R21CA127042Apr 1, 2007 - Mar 31, 2010
    Role: Principal Investigator
    Viral Genes Essential for MHV-68 Persistent Infection in the Spleen
    NIH/NCI R21CA120761Dec 2, 2006 - Nov 30, 2009
    Role: Principal Investigator
    Interdisciplinary Training in Virology and Gene Therapy
    NIH/NIAID T32AI060567Sep 1, 2004 - Aug 31, 2019
    Role: Principal Investigator
    Role of Interleukin-6 in Gammaherpesvirus replication
    NIH/NIDCR R01DE015752Jul 21, 2003 - May 31, 2008
    Role: Principal Investigator
    Reactivation of Kaposi's Sarcoma-Associated Herpesvirus
    NIH/NCI R01CA091791Apr 1, 2001 - Jan 31, 2018
    Role: Principal Investigator
    Viral Lysis of Kaposi's Sarcoma Tumor Cells
    NIH/NIDCR R01DE014153Apr 1, 2001 - Mar 31, 2005
    Role: Principal Investigator
    NIH/NCI R01CA083525Sep 20, 1999 - Aug 31, 2003
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Yong J, Tian J, Dang H, Wu TT, Atkinson MA, Sun R, Kaufman DL. Increased risk for T cell autoreactivity to ß-cell antigens in the mice expressing the Avy obesity-associated gene. Sci Rep. 2019 Mar 12; 9(1):4269. PMID: 30862859.
      View in: PubMed
    2. Thaker SK, Chapa T, Garcia G, Gong D, Schmid EW, Arumugaswami V, Sun R, Christofk HR. Differential Metabolic Reprogramming by Zika Virus Promotes Cell Death in Human versus Mosquito Cells. Cell Metab. 2019 May 07; 29(5):1206-1216.e4. PMID: 30827860.
      View in: PubMed
    3. Srikanth S, Woo JS, Wu B, El-Sherbiny YM, Leung J, Chupradit K, Rice L, Seo GJ, Calmettes G, Ramakrishna C, Cantin E, An DS, Sun R, Wu TT, Jung JU, Savic S, Gwack Y. The Ca2+ sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum. Nat Immunol. 2019 Feb; 20(2):152-162. PMID: 30643259.
      View in: PubMed
    4. Fulcher JA, Du Y, Zhang TH, Sun R, Landovitz RJ. Emergence of Integrase Resistance Mutations During Initial Therapy Containing Dolutegravir. Clin Infect Dis. 2018 Aug 16; 67(5):791-794. PMID: 29933437.
      View in: PubMed
    5. Gong D, Zhang TH, Zhao D, Du Y, Chapa TJ, Shi Y, Wang L, Contreras D, Zeng G, Shi PY, Wu TT, Arumugaswami V, Sun R. High-Throughput Fitness Profiling of Zika Virus E Protein Reveals Different Roles for Glycosylation during Infection of Mammalian and Mosquito Cells. iScience. 2018 Mar 23; 1:97-111. PMID: 30227960.
      View in: PubMed
    6. Du Y, Xin L, Shi Y, Zhang TH, Wu NC, Dai L, Gong D, Brar G, Shu S, Luo J, Reiley W, Tseng YW, Bai H, Wu TT, Wang J, Shu Y, Sun R. Genome-wide identification of interferon-sensitive mutations enables influenza vaccine design. Science. 2018 01 19; 359(6373):290-296. PMID: 29348231.
      View in: PubMed
    7. Dai X, Gong D, Lim H, Jih J, Wu TT, Sun R, Zhou ZH. Structure and mutagenesis reveal essential capsid protein interactions for KSHV replication. Nature. 2018 01 25; 553(7689):521-525. PMID: 29342139.
      View in: PubMed
    8. Hong M, Tang K, Qian J, Deng H, Zeng M, Zheng S, Ding K, Du Y, Sun R. Immunotherapy for EBV-Associated Nasopharyngeal Carcinoma. Crit Rev Oncog. 2018; 23(3-4):219-234. PMID: 30311576.
      View in: PubMed
    9. Dai X, Wu L, Sun R, Zhou ZH. Atomic Structures of Minor Proteins VI and VII in Human Adenovirus. J Virol. 2017 Dec 15; 91(24). PMID: 28978703.
      View in: PubMed
    10. Watanabe M, Buth JE, Vishlaghi N, de la Torre-Ubieta L, Taxidis J, Khakh BS, Coppola G, Pearson CA, Yamauchi K, Gong D, Dai X, Damoiseaux R, Aliyari R, Liebscher S, Schenke-Layland K, Caneda C, Huang EJ, Zhang Y, Cheng G, Geschwind DH, Golshani P, Sun R, Novitch BG. Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection. Cell Rep. 2017 Oct 10; 21(2):517-532. PMID: 29020636.
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    11. Du Y, Chi X, Wang C, Jiang J, Kong F, Yan H, Wang X, Li J, Wu NC, Dai L, Zhang TH, Shu S, Zhou J, Yoshizawa JM, Li X, Bhattacharya D, Wu TT, Niu J, Sun R. Quantifying perinatal transmission of Hepatitis B viral quasispecies by tag linkage deep sequencing. Sci Rep. 2017 08 31; 7(1):10168. PMID: 28860476.
      View in: PubMed
    12. Gorin AM, Du Y, Liu FY, Zhang TH, Ng HL, Hofmann C, Cumberland WG, Sun R, Yang OO. HIV-1 epitopes presented by MHC class I types associated with superior immune containment of viremia have highly constrained fitness landscapes. PLoS Pathog. 2017 Aug; 13(8):e1006541. PMID: 28787455.
      View in: PubMed
    13. Gong D, Dai X, Xiao Y, Du Y, Chapa TJ, Johnson JR, Li X, Krogan NJ, Deng H, Wu TT, Sun R. Virus-Like Vesicles of Kaposi's Sarcoma-Associated Herpesvirus Activate Lytic Replication by Triggering Differentiation Signaling. J Virol. 2017 08 01; 91(15). PMID: 28515293.
      View in: PubMed
    14. Chapa TJ, Du Y, Sun R, Yu D, French AR. Proteomic and phylogenetic coevolution analyses of pM79 and pM92 identify interactions with RNA polymerase II and delineate the murine cytomegalovirus late transcription complex. J Gen Virol. 2017 02; 98(2):242-250. PMID: 27926822.
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    15. Qi H, Chu V, Wu NC, Chen Z, Truong S, Brar G, Su SY, Du Y, Arumugaswami V, Olson CA, Chen SH, Lin CY, Wu TT, Sun R. Systematic identification of anti-interferon function on hepatitis C virus genome reveals p7 as an immune evasion protein. Proc Natl Acad Sci U S A. 2017 02 21; 114(8):2018-2023. PMID: 28159892.
      View in: PubMed
    16. Dai X, Li Z, Lai M, Shu S, Du Y, Zhou ZH, Sun R. In situ structures of the genome and genome-delivery apparatus in a single-stranded RNA virus. Nature. 2017 01 05; 541(7635):112-116. PMID: 27992877.
      View in: PubMed
    17. Gong D, Kim YH, Xiao Y, Du Y, Xie Y, Lee KK, Feng J, Farhat N, Zhao D, Shu S, Dai X, Chanda SK, Rana TM, Krogan NJ, Sun R, Wu TT. A Herpesvirus Protein Selectively Inhibits Cellular mRNA Nuclear Export. Cell Host Microbe. 2016 Nov 09; 20(5):642-653. PMID: 27832591.
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    18. Du Y, Wu NC, Jiang L, Zhang T, Gong D, Shu S, Wu TT, Sun R. Annotating Protein Functional Residues by Coupling High-Throughput Fitness Profile and Homologous-Structure Analysis. MBio. 2016 11 01; 7(6). PMID: 27803181.
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    19. Wu NC, Dai L, Olson CA, Lloyd-Smith JO, Sun R. Adaptation in protein fitness landscapes is facilitated by indirect paths. Elife. 2016 07 08; 5. PMID: 27391790.
      View in: PubMed
    20. Zhang TH, Wu NC, Sun R. A benchmark study on error-correction by read-pairing and tag-clustering in amplicon-based deep sequencing. BMC Genomics. 2016 Feb 12; 17:108. PMID: 26868371; PMCID: PMC4751728.
    21. Wu NC, Du Y, Le S, Young AP, Zhang TH, Wang Y, Zhou J, Yoshizawa JM, Dong L, Li X, Wu TT, Sun R. Coupling high-throughput genetics with phylogenetic information reveals an epistatic interaction on the influenza A virus M segment. BMC Genomics. 2016 Jan 12; 17:46. PMID: 26754751; PMCID: PMC4710013.
    22. York AG, Williams KJ, Argus JP, Zhou QD, Brar G, Vergnes L, Gray EE, Zhen A, Wu NC, Yamada DH, Cunningham CR, Tarling EJ, Wilks MQ, Casero D, Gray DH, Yu AK, Wang ES, Brooks DG, Sun R, Kitchen SG, Wu TT, Reue K, Stetson DB, Bensinger SJ. Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling. Cell. 2015 Dec 17; 163(7):1716-29. PMID: 26686653; PMCID: PMC4783382 [Available on 12/17/16].
    23. Wu NC, Olson CA, Sun R. High-throughput identification of protein mutant stability computed from a double mutant fitness landscape. Protein Sci. 2016 Feb; 25(2):530-9. PMID: 26540565; PMCID: PMC4815338 [Available on 02/01/17].
    24. Feng J, Gong D, Fu X, Wu TT, Wang J, Chang J, Zhou J, Lu G, Wang Y, Sun R. M1 of Murine Gamma-Herpesvirus 68 Induces Endoplasmic Reticulum Chaperone Production. Sci Rep. 2015 Nov 30; 5:17228. PMID: 26615759.
      View in: PubMed
    25. Qi H, Wu NC, Du Y, Wu TT, Sun R. High-resolution genetic profile of viral genomes: why it matters. Curr Opin Virol. 2015 Oct; 14:62-70. PMID: 26364133.
      View in: PubMed
    26. Wu NC, Olson CA, Du Y, Le S, Tran K, Remenyi R, Gong D, Al-Mawsawi LQ, Qi H, Wu TT, Sun R. Functional Constraint Profiling of a Viral Protein Reveals Discordance of Evolutionary Conservation and Functionality. PLoS Genet. 2015 Jul; 11(7):e1005310. PMID: 26132554.
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    27. Ke R, Loverdo C, Qi H, Sun R, Lloyd-Smith JO. Rational Design and Adaptive Management of Combination Therapies for Hepatitis C Virus Infection. PLoS Comput Biol. 2015 Jun; 11(6):e1004040. PMID: 26125950.
      View in: PubMed
    28. Shen Y, Zhang S, Sun R, Wu T, Qian J. Understanding the interplay between host immunity and Epstein-Barr virus in NPC patients. Emerg Microbes Infect. 2015 Mar; 4(3):e20. PMID: 26038769.
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    29. Al-Mawsawi LQ, Wu NC, Olson CA, Shi VC, Qi H, Zheng X, Wu TT, Sun R. High-throughput profiling of point mutations across the HIV-1 genome. Retrovirology. 2014 Dec 19; 11:124. PMID: 25522661; PMCID: PMC4300175.
    30. Olson CA, Wu NC, Sun R. A comprehensive biophysical description of pairwise epistasis throughout an entire protein domain. Curr Biol. 2014 Nov 17; 24(22):2643-51. PMID: 25455030; PMCID: PMC4254498.
    31. Remenyi R, Qi H, Su SY, Chen Z, Wu NC, Arumugaswami V, Truong S, Chu V, Stokelman T, Lo HH, Olson CA, Wu TT, Chen SH, Lin CY, Sun R. A comprehensive functional map of the hepatitis C virus genome provides a resource for probing viral proteins. MBio. 2014 Sep 30; 5(5):e01469-14. PMID: 25271282; PMCID: PMC4196222.
    32. Dai X, Gong D, Wu TT, Sun R, Zhou ZH. Organization of capsid-associated tegument components in Kaposi's sarcoma-associated herpesvirus. J Virol. 2014 Nov; 88(21):12694-702. PMID: 25142590.
      View in: PubMed
    33. Gong D, Wu NC, Xie Y, Feng J, Tong L, Brulois KF, Luan H, Du Y, Jung JU, Wang CY, Kang MK, Park NH, Sun R, Wu TT. Kaposi's sarcoma-associated herpesvirus ORF18 and ORF30 are essential for late gene expression during lytic replication. J Virol. 2014 Oct; 88(19):11369-82. PMID: 25056896; PMCID: PMC4178812.
    34. Al-Mawsawi LQ, Wu NC, De La Cruz J, Shi VC, Wu TT, Daar ES, Lewis MJ, Yang OO, Sun R. Short communication: HIV-1 gag genetic variation in a single acutely infected participant defined by high-resolution deep sequencing. AIDS Res Hum Retroviruses. 2014 Aug; 30(8):806-11. PMID: 24914638.
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    35. Wu NC, Young AP, Al-Mawsawi LQ, Olson CA, Feng J, Qi H, Luan HH, Li X, Wu TT, Sun R. High-throughput identification of loss-of-function mutations for anti-interferon activity in the influenza A virus NS segment. J Virol. 2014 Sep 01; 88(17):10157-64. PMID: 24965464; PMCID: PMC4136320.
    36. Mangul S, Wu NC, Mancuso N, Zelikovsky A, Sun R, Eskin E. Accurate viral population assembly from ultra-deep sequencing data. Bioinformatics. 2014 Jun 15; 30(12):i329-37. PMID: 24932001; PMCID: PMC4058922.
    37. Wu NC, De La Cruz J, Al-Mawsawi LQ, Olson CA, Qi H, Luan HH, Nguyen N, Du Y, Le S, Wu TT, Li X, Lewis MJ, Yang OO, Sun R. HIV-1 quasispecies delineation by tag linkage deep sequencing. PLoS One. 2014; 9(5):e97505. PMID: 24842159.
      View in: PubMed
    38. Wu NC, Young AP, Al-Mawsawi LQ, Olson CA, Feng J, Qi H, Chen SH, Lu IH, Lin CY, Chin RG, Luan HH, Nguyen N, Nelson SF, Li X, Wu TT, Sun R. High-throughput profiling of influenza A virus hemagglutinin gene at single-nucleotide resolution. Sci Rep. 2014 May 13; 4:4942. PMID: 24820965; PMCID: PMC4018626.
    39. Feng J, De Jesus PD, Su V, Han S, Gong D, Wu NC, Tian Y, Li X, Wu TT, Chanda SK, Sun R. RIOK3 is an adaptor protein required for IRF3-mediated antiviral type I interferon production. J Virol. 2014 Jul; 88(14):7987-97. PMID: 24807708; PMCID: PMC4097797.
    40. Qi H, Olson CA, Wu NC, Ke R, Loverdo C, Chu V, Truong S, Remenyi R, Chen Z, Du Y, Su SY, Al-Mawsawi LQ, Wu TT, Chen SH, Lin CY, Zhong W, Lloyd-Smith JO, Sun R. A quantitative high-resolution genetic profile rapidly identifies sequence determinants of hepatitis C viral fitness and drug sensitivity. PLoS Pathog. 2014 Apr; 10(4):e1004064. PMID: 24722365; PMCID: PMC3983061.
    41. Sun RJ, Kalbfleisch JD, Schaubel DE. A weighted cumulative sum (WCUSUM) to monitor medical outcomes with dependent censoring. Stat Med. 2014 Aug 15; 33(18):3114-29. PMID: 24623573.
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    42. Wong-Ho E, Wu TT, Davis ZH, Zhang B, Huang J, Gong H, Deng H, Liu F, Glaunsinger B, Sun R. Unconventional sequence requirement for viral late gene core promoters of murine gammaherpesvirus 68. J Virol. 2014 Mar; 88(6):3411-22. PMID: 24403583; PMCID: PMC3957950.
    43. Ke R, Loverdo C, Qi H, Olson CA, Wu NC, Sun R, Lloyd-Smith JO. Modelling clinical data shows active tissue concentration of daclatasvir is 10-fold lower than its plasma concentration. J Antimicrob Chemother. 2014 Mar; 69(3):724-7. PMID: 24169581; PMCID: PMC3922152.
    44. Wei Q, Qi H, Luo W, Tseng D, Ki SJ, Wan Z, Göröcs Z, Bentolila LA, Wu TT, Sun R, Ozcan A. Fluorescent imaging of single nanoparticles and viruses on a smart phone. ACS Nano. 2013 Oct 22; 7(10):9147-55. PMID: 24016065; PMCID: PMC3951925.
    45. Sun RJ, Kalbfleisch JD. A risk-adjusted O-E CUSUM with monitoring bands for monitoring medical outcomes. Biometrics. 2013 Mar; 69(1):62-9. PMID: 23383682.
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    46. Wei Q, McLeod E, Qi H, Wan Z, Sun R, Ozcan A. On-chip cytometry using plasmonic nanoparticle enhanced lensfree holography. Sci Rep. 2013; 3:1699. PMID: 23608952; PMCID: PMC3632884.
    47. Wu NC, Young AP, Dandekar S, Wijersuriya H, Al-Mawsawi LQ, Wu TT, Sun R. Systematic identification of H274Y compensatory mutations in influenza A virus neuraminidase by high-throughput screening. J Virol. 2013 Jan; 87(2):1193-9. PMID: 23152521; PMCID: PMC3554097.
    48. Olson CA, Nie J, Diep J, Al-Shyoukh I, Takahashi TT, Al-Mawsawi LQ, Bolin JM, Elwell AL, Swanson S, Stewart R, Thomson JA, Soh HT, Roberts RW, Sun R. Single-round, multiplexed antibody mimetic design through mRNA display. Angew Chem Int Ed Engl. 2012 Dec 07; 51(50):12449-53. PMID: 23125174; PMCID: PMC3832244.
    49. Wu TT, Qian J, Ang J, Sun R. Vaccine prospect of Kaposi sarcoma-associated herpesvirus. Curr Opin Virol. 2012 Aug; 2(4):482-8. PMID: 22795202.
      View in: PubMed
    50. Li X, Chen S, Sun R. Cdk1 inhibition induces mutually inhibitory apoptosis and reactivation of Kaposi's sarcoma-associated herpesvirus. J Virol. 2012 Jun; 86(12):6668-76. PMID: 22496227.
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    51. Weng D, Qi H, Wu TT, Yan M, Sun R, Lu Y. Visible light powered self-disinfecting coatings for influenza viruses. Nanoscale. 2012 Apr 28; 4(9):2870-4. PMID: 22456700.
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    52. Lee S, Salwinski L, Zhang C, Chu D, Sampankanpanich C, Reyes NA, Vangeloff A, Xing F, Li X, Wu TT, Sahasrabudhe S, Deng H, Lacount DJ, Sun R. An integrated approach to elucidate the intra-viral and viral-cellular protein interaction networks of a gamma-herpesvirus. PLoS Pathog. 2011 Oct; 7(10):e1002297. PMID: 22028648; PMCID: PMC3197595.
    53. Leang RS, Wu TT, Hwang S, Liang LT, Tong L, Truong JT, Sun R. The anti-interferon activity of conserved viral dUTPase ORF54 is essential for an effective MHV-68 infection. PLoS Pathog. 2011 Oct; 7(10):e1002292. PMID: 21998588.
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    54. Liu Y, Tian X, Leitner WW, Aldridge ME, Zheng J, Yu Z, Restifo NP, Weiss R, Scheiblhofer S, Xie C, Sun R, Cheng G, Zeng G. Polymeric structure and host Toll-like receptor 4 dictate immunogenicity of NY-ESO-1 antigen in vivo. J Biol Chem. 2011 Oct 28; 286(43):37077-84. PMID: 21900253; PMCID: PMC3199455.
    55. Olson CA, Adams JD, Takahashi TT, Qi H, Howell SM, Wu TT, Roberts RW, Sun R, Soh HT. Rapid mRNA-display selection of an IL-6 inhibitor using continuous-flow magnetic separation. Angew Chem Int Ed Engl. 2011 Aug 29; 50(36):8295-8. PMID: 21761516; PMCID: PMC3747967.
    56. Yu F, Al-Shyoukh I, Feng J, Li X, Liao CW, Ho CM, Shamma JS, Sun R. Control of Kaposi's sarcoma-associated herpesvirus reactivation induced by multiple signals. PLoS One. 2011; 6(6):e20998. PMID: 21904595; PMCID: PMC3125160.
    57. Al-Shyoukh I, Yu F, Feng J, Yan K, Dubinett S, Ho CM, Shamma JS, Sun R. Systematic quantitative characterization of cellular responses induced by multiple signals. BMC Syst Biol. 2011 May 30; 5:88. PMID: 21624115; PMCID: PMC3138445.
    58. Wu TT, Liao HI, Tong L, Leang RS, Smith G, Sun R. Construction and characterization of an infectious murine gammaherpesivrus-68 bacterial artificial chromosome. J Biomed Biotechnol. 2011; 2011:926258. PMID: 21197474; PMCID: PMC3006494.
    59. Wu TT, Blackman MA, Sun R. Prospects of a novel vaccination strategy for human gamma-herpesviruses. Immunol Res. 2010 Dec; 48(1-3):122-46. PMID: 20717741; PMCID: PMC3931126.
    60. Li X, Feng J, Sun R. Oxidative stress induces reactivation of Kaposi's sarcoma-associated herpesvirus and death of primary effusion lymphoma cells. J Virol. 2011 Jan; 85(2):715-24. PMID: 21068240.
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    61. Li X, Chen S, Feng J, Deng H, Sun R. Myc is required for the maintenance of Kaposi's sarcoma-associated herpesvirus latency. J Virol. 2010 Sep; 84(17):8945-8. PMID: 20573831; PMCID: PMC2919007.
    62. Brown HJ, Peng L, Harada JN, Walker JR, Cole S, Lin SF, Zack JA, Chanda SK, Sun R. Gene expression and transcription factor profiling reveal inhibition of transcription factor cAMP-response element-binding protein by gamma-herpesvirus replication and transcription activator. J Biol Chem. 2010 Aug 13; 285(33):25139-53. PMID: 20516076; PMCID: PMC2919076.
    63. Peng L, Ryazantsev S, Sun R, Zhou ZH. Three-dimensional visualization of gammaherpesvirus life cycle in host cells by electron tomography. Structure. 2010 Jan 13; 18(1):47-58. PMID: 20152152; PMCID: PMC2866045.
    64. Jia Q, Freeman ML, Yager EJ, McHardy I, Tong L, Martinez-Guzman D, Rickabaugh T, Hwang S, Blackman MA, Sun R, Wu TT. Induction of protective immunity against murine gammaherpesvirus 68 infection in the absence of viral latency. J Virol. 2010 Mar; 84(5):2453-65. PMID: 20015983; PMCID: PMC2820913.
    65. Gonzalez O, Fontanes V, Raychaudhuri S, Loo R, Loo J, Arumugaswami V, Sun R, Dasgupta A, French SW. The heat shock protein inhibitor Quercetin attenuates hepatitis C virus production. Hepatology. 2009 Dec; 50(6):1756-64. PMID: 19839005; PMCID: PMC3846025.
    66. Li X, Feng J, Chen S, Peng L, He WW, Qi J, Deng H, Sun R. Tpl2/AP-1 enhances murine gammaherpesvirus 68 lytic replication. J Virol. 2010 Feb; 84(4):1881-90. PMID: 19939924; PMCID: PMC2812393.
    67. Peng L, Wu TT, Tchieu JH, Feng J, Brown HJ, Feng J, Li X, Qi J, Deng H, Vivanco I, Mellinghoff IK, Jamieson C, Sun R. Inhibition of the phosphatidylinositol 3-kinase-Akt pathway enhances gamma-2 herpesvirus lytic replication and facilitates reactivation from latency. J Gen Virol. 2010 Feb; 91(Pt 2):463-9. PMID: 19864499; PMCID: PMC2888311.
    68. Liao HI, Olson CA, Hwang S, Deng H, Wong E, Baric RS, Roberts RW, Sun R. mRNA display design of fibronectin-based intrabodies that detect and inhibit severe acute respiratory syndrome coronavirus nucleocapsid protein. J Biol Chem. 2009 Jun 26; 284(26):17512-20. PMID: 19364769; PMCID: PMC2719390.
    69. Hwang S, Kim KS, Flano E, Wu TT, Tong LM, Park AN, Song MJ, Sanchez DJ, O'Connell RM, Cheng G, Sun R. Conserved herpesviral kinase promotes viral persistence by inhibiting the IRF-3-mediated type I interferon response. Cell Host Microbe. 2009 Feb 19; 5(2):166-78. PMID: 19218087; PMCID: PMC2749518.
    70. Miyahira AK, Shahangian A, Hwang S, Sun R, Cheng G. TANK-binding kinase-1 plays an important role during in vitro and in vivo type I IFN responses to DNA virus infections. J Immunol. 2009 Feb 15; 182(4):2248-57. PMID: 19201879; PMCID: PMC2656676.
    71. Sun CP, Usui T, Yu F, Al-Shyoukh I, Shamma J, Sun R, Ho CM. Integrative systems control approach for reactivating Kaposi's sarcoma-associated herpesvirus (KSHV) with combinatory drugs. Integr Biol (Camb). 2009 Jan; 1(1):123-30. PMID: 19851479.
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    72. Wu TT, Park T, Kim H, Tran T, Tong L, Martinez-Guzman D, Reyes N, Deng H, Sun R. ORF30 and ORF34 are essential for expression of late genes in murine gammaherpesvirus 68. J Virol. 2009 Mar; 83(5):2265-73. PMID: 19091863.
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    73. Arumugaswami V, Sitapara R, Hwang S, Song MJ, Ho TN, Su NQ, Sue EY, Kanagavel V, Xing F, Zhang X, Zhao M, Deng H, Wu TT, Kanagavel S, Zhang L, Dandekar S, Papp J, Sun R. High-resolution functional profiling of a gammaherpesvirus RTA locus in the context of the viral genome. J Virol. 2009 Feb; 83(4):1811-22. PMID: 19073723; PMCID: PMC2643748.
    74. Arumugaswami V, Remenyi R, Kanagavel V, Sue EY, Ngoc Ho T, Liu C, Fontanes V, Dasgupta A, Sun R. High-resolution functional profiling of hepatitis C virus genome. PLoS Pathog. 2008 Oct; 4(10):e1000182. PMID: 18927624; PMCID: PMC2564836.
    75. Hwang S, Wu TT, Tong LM, Kim KS, Martinez-Guzman D, Colantonio AD, Uittenbogaart CH, Sun R. Persistent gammaherpesvirus replication and dynamic interaction with the host in vivo. J Virol. 2008 Dec; 82(24):12498-509. PMID: 18842717; PMCID: PMC2593345.
    76. Song C, Jiang H, Mancuso A, Amirbekian B, Peng L, Sun R, Shah SS, Zhou ZH, Ishikawa T, Miao J. Quantitative imaging of single, unstained viruses with coherent x rays. Phys Rev Lett. 2008 Oct 10; 101(15):158101. PMID: 18999646.
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    77. Lee S, Deng H, Yu F, Melega WP, Damoiseaux R, Bradley KA, Sun R. Regulation of Kaposi's sarcoma-associated herpesvirus reactivation by dopamine receptor-mediated signaling pathways. J Acquir Immune Defic Syndr. 2008 Aug 15; 48(5):531-40. PMID: 18645521.
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