Olcese Riccardo

Title(s)Professor, Anesthesiology
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    Other Positions
    Title(s)Professor, Physiology

    Title(s)Faculty, Cardiovascular Research Laboratory

    Collapse Research 
    Collapse Research Activities and Funding
    The Late L-type Ca Current as the Target for a New Class of Antiarrhythmics
    NIH/NHLBI R01HL134346Jul 1, 2017 - Mar 31, 2021
    Role: Principal Investigator
    DRVCF, a new optical method for real-time, high resolution, intramolecular distance measurements in conducting ion channels
    NIH/NINDS R21NS101734Mar 15, 2017 - Feb 28, 2019
    Role: Principal Investigator
    Voltage-driven Structural Transitions in Voltage-Gated Calcium Channels
    NIH/NIGMS R01GM110276Dec 1, 2014 - Nov 30, 2018
    Role: Principal Investigator
    BK(Ca) channel in heart mitochondria
    NIH/NHLBI R01HL107418Apr 15, 2012 - Feb 29, 2016
    Role: Principal Investigator
    Structural Changes in BKCa Channels During Gating
    NIH/NIGMS R01GM082289Dec 1, 2002 - Feb 28, 2013
    Role: Principal Investigator
    Structural Changes in BKCa Channels During Gating
    NIH/NINDS R01NS043240Dec 1, 2002 - Nov 30, 2007
    Role: Principal Investigator
    Regulation of calcium-activated potassium channels by lipid messengers
    NIH/NIGMS R01GM057654May 1, 1998 - May 31, 2015
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Pantazis A, Westerberg K, Althoff T, Abramson J, Olcese R. Harnessing photoinduced electron transfer to optically determine protein sub-nanoscale atomic distances. Nat Commun. 2018 Nov 09; 9(1):4738. PMID: 30413716.
      View in: PubMed
    2. John S, Kim B, Olcese R, Goldhaber JI, Ottolia M. Molecular determinants of pH regulation in the cardiac Na+-Ca2+ exchanger. J Gen Physiol. 2018 Feb 05; 150(2):245-257. PMID: 29301861.
      View in: PubMed
    3. Schwingshackl A, Lopez B, Teng B, Luellen C, Lesage F, Belperio J, Olcese R, Waters CM. Hyperoxia treatment of TREK-1/TREK-2/TRAAK-deficient mice is associated with a reduction in surfactant proteins. Am J Physiol Lung Cell Mol Physiol. 2017 Dec 01; 313(6):L1030-L1046. PMID: 28839101.
      View in: PubMed
    4. Karagueuzian HS, Pezhouman A, Angelini M, Olcese R. Enhanced Late Na and Ca Currents as Effective Antiarrhythmic Drug Targets. Front Pharmacol. 2017; 8:36. PMID: 28220073.
      View in: PubMed
    5. Zhang J, Li M, Zhang Z, Zhu R, Olcese R, Stefani E, Toro L. The mitochondrial BKCa channel cardiac interactome reveals BKCa association with the mitochondrial import receptor subunit Tom22, and the adenine nucleotide translocator. Mitochondrion. 2017 03; 33:84-101. PMID: 27592226.
      View in: PubMed
    6. Savalli N, Pantazis A, Sigg D, Weiss JN, Neely A, Olcese R. The a2d-1 subunit remodels CaV1.2 voltage sensors and allows Ca2+ influx at physiological membrane potentials. J Gen Physiol. 2016 08; 148(2):147-59. PMID: 27481713.
      View in: PubMed
    7. Prudat Y, Madhvani RV, Angelini M, Borgstom NP, Garfinkel A, Karagueuzian HS, Weiss JN, de Lange E, Olcese R, Kucera JP. Stochastic pacing reveals the propensity to cardiac action potential alternans and uncovers its underlying dynamics. J Physiol. 2016 05 01; 594(9):2537-53. PMID: 26563830; PMCID: PMC4850193 [Available on 04/28/17].
    8. Madhvani RV, Angelini M, Xie Y, Pantazis A, Suriany S, Borgstrom NP, Garfinkel A, Qu Z, Weiss JN, Olcese R. Targeting the late component of the cardiac L-type Ca2+ current to suppress early afterdepolarizations. J Gen Physiol. 2015 May; 145(5):395-404. PMID: 25918358; PMCID: PMC4411259.
    9. Weiss JN, Garfinkel A, Karagueuzian HS, Nguyen TP, Olcese R, Chen PS, Qu Z. Perspective: a dynamics-based classification of ventricular arrhythmias. J Mol Cell Cardiol. 2015 May; 82:136-52. PMID: 25769672; PMCID: PMC4405495.
    10. Pantazis A, Savalli N, Sigg D, Neely A, Olcese R. Functional heterogeneity of the four voltage sensors of a human L-type calcium channel. Proc Natl Acad Sci U S A. 2014 Dec 23; 111(51):18381-6. PMID: 25489110; PMCID: PMC4280600.
    11. Qu Z, Xie LH, Olcese R, Karagueuzian HS, Chen PS, Garfinkel A, Weiss JN. Early afterdepolarizations in cardiac myocytes: beyond reduced repolarization reserve. Cardiovasc Res. 2013 Jul 01; 99(1):6-15. PMID: 23619423; PMCID: PMC3687754.
    12. Pantazis A, Olcese R. Relative transmembrane segment rearrangements during BK channel activation resolved by structurally assigned fluorophore-quencher pairing. J Gen Physiol. 2012 Aug; 140(2):207-18. PMID: 22802360; PMCID: PMC3409098.
    13. Savalli N, Pantazis A, Yusifov T, Sigg D, Olcese R. The contribution of RCK domains to human BK channel allosteric activation. J Biol Chem. 2012 Jun 22; 287(26):21741-50. PMID: 22556415; PMCID: PMC3381136.
    14. Madhvani RV, Xie Y, Pantazis A, Garfinkel A, Qu Z, Weiss JN, Olcese R. Shaping a new Ca²? conductance to suppress early afterdepolarizations in cardiac myocytes. J Physiol. 2011 Dec 15; 589(Pt 24):6081-92. PMID: 22025660; PMCID: PMC3286687.
    15. Olcese R. I(KACh) at the whim of a capricious M2R. J Physiol. 2011 Apr 15; 589(Pt 8):1869-70. PMID: 21498381; PMCID: PMC3090587.
    16. Javaherian AD, Yusifov T, Pantazis A, Franklin S, Gandhi CS, Olcese R. Metal-driven operation of the human large-conductance voltage- and Ca2+-dependent potassium channel (BK) gating ring apparatus. J Biol Chem. 2011 Jun 10; 286(23):20701-9. PMID: 21471215; PMCID: PMC3121532.
    17. Pantazis A, Kohanteb AP, Olcese R. Relative motion of transmembrane segments S0 and S4 during voltage sensor activation in the human BK(Ca) channel. J Gen Physiol. 2010 Dec; 136(6):645-57. PMID: 21078868; PMCID: PMC2995153.
    18. Yusifov T, Javaherian AD, Pantazis A, Gandhi CS, Olcese R. The RCK1 domain of the human BKCa channel transduces Ca2+ binding into structural rearrangements. J Gen Physiol. 2010 Aug; 136(2):189-202. PMID: 20624858; PMCID: PMC2912072.
    19. Pantazis A, Gudzenko V, Savalli N, Sigg D, Olcese R. Operation of the voltage sensor of a human voltage- and Ca2+-activated K+ channel. Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4459-64. PMID: 20160086; PMCID: PMC2840143.
    20. Olcese R. It's spring-time for slow inactivation. J Gen Physiol. 2009 Dec; 134(6):457-9. PMID: 19917731; PMCID: PMC2806423.
    21. Mahajan A, Sato D, Shiferaw Y, Baher A, Xie LH, Peralta R, Olcese R, Garfinkel A, Qu Z, Weiss JN. Modifying L-type calcium current kinetics: consequences for cardiac excitation and arrhythmia dynamics. Biophys J. 2008 Jan 15; 94(2):411-23. PMID: 18160661; PMCID: PMC2157257.
    22. Mahajan A, Shiferaw Y, Sato D, Baher A, Olcese R, Xie LH, Yang MJ, Chen PS, Restrepo JG, Karma A, Garfinkel A, Qu Z, Weiss JN. A rabbit ventricular action potential model replicating cardiac dynamics at rapid heart rates. Biophys J. 2008 Jan 15; 94(2):392-410. PMID: 18160660; PMCID: PMC2157228.
    23. Gandhi CS, Olcese R. The voltage-clamp fluorometry technique. Methods Mol Biol. 2008; 491:213-31. PMID: 18998096.
      View in: PubMed
    24. Yusifov T, Savalli N, Gandhi CS, Ottolia M, Olcese R. The RCK2 domain of the human BKCa channel is a calcium sensor. Proc Natl Acad Sci U S A. 2008 Jan 08; 105(1):376-81. PMID: 18162557; PMCID: PMC2224220.
    25. Savalli N, Kondratiev A, de Quintana SB, Toro L, Olcese R. Modes of operation of the BKCa channel beta2 subunit. J Gen Physiol. 2007 Jul; 130(1):117-31. PMID: 17591990; PMCID: PMC2154362.
    26. Olcese R. And yet it moves: conformational States of the Ca2+ channel pore. J Gen Physiol. 2007 Jun; 129(6):457-9. PMID: 17535958; PMCID: PMC2151624.
    27. Gudzenko V, Shiferaw Y, Savalli N, Vyas R, Weiss JN, Olcese R. Influence of channel subunit composition on L-type Ca2+ current kinetics and cardiac wave stability. Am J Physiol Heart Circ Physiol. 2007 Sep; 293(3):H1805-15. PMID: 17545475.
      View in: PubMed
    28. Savalli N, Kondratiev A, Toro L, Olcese R. Voltage-dependent conformational changes in human Ca(2+)- and voltage-activated K(+) channel, revealed by voltage-clamp fluorometry. Proc Natl Acad Sci U S A. 2006 Aug 15; 103(33):12619-24. PMID: 16895996; PMCID: PMC1567928.
    29. Chen ZW, Chang CS, Leil TA, Olcese R, Olsen RW. GABAA receptor-associated protein regulates GABAA receptor cell-surface number in Xenopus laevis oocytes. Mol Pharmacol. 2005 Jul; 68(1):152-9. PMID: 15814572.
      View in: PubMed
    30. Haug T, Sigg D, Ciani S, Toro L, Stefani E, Olcese R. Regulation of K+ flow by a ring of negative charges in the outer pore of BKCa channels. Part I: Aspartate 292 modulates K+ conduction by external surface charge effect. J Gen Physiol. 2004 Aug; 124(2):173-84. PMID: 15277578; PMCID: PMC2229624.
    31. Haug T, Olcese R, Toro L, Stefani E. Regulation of K+ flow by a ring of negative charges in the outer pore of BKCa channels. Part II: Neutralization of aspartate 292 reduces long channel openings and gating current slow component. J Gen Physiol. 2004 Aug; 124(2):185-97. PMID: 15277579; PMCID: PMC2229619.
    32. Latorre R, Olcese R, Basso C, Gonzalez C, Munoz F, Cosmelli D, Alvarez O. Molecular coupling between voltage sensor and pore opening in the Arabidopsis inward rectifier K+ channel KAT1. J Gen Physiol. 2003 Oct; 122(4):459-69. PMID: 14517271; PMCID: PMC2233774.
    33. Chang CS, Olcese R, Olsen RW. A single M1 residue in the beta2 subunit alters channel gating of GABAA receptor in anesthetic modulation and direct activation. J Biol Chem. 2003 Oct 31; 278(44):42821-8. PMID: 12939268.
      View in: PubMed
    34. Helguera G, Olcese R, Song M, Toro L, Stefani E. Tissue-specific regulation of Ca(2+) channel protein expression by sex hormones. Biochim Biophys Acta. 2002 Jan 15; 1569(1-3):59-66. PMID: 11853958.
      View in: PubMed