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Mitragotri Samir

Title(s)CNSI-UCSB, California NanoSystems Institute
Phone(805) 893-3141
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    Title(s)Professor, Chemical Engineering UCSB


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Banerjee A, Chen R, Arafin S, Mitragotri S. Intestinal iontophoresis from mucoadhesive patches: a strategy for oral delivery. J Control Release. 2019 Jan 29; 297:71-78. PMID: 30707901.
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    2. Singh B, Mitragotri S. Harnessing cells to deliver nanoparticle drugs to treat cancer. Biotechnol Adv. 2019 Jan 10. PMID: 30639928.
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    3. Zhao Z, Ukidve A, Krishnan V, Mitragotri S. Effect of physicochemical and surface properties on in vivo fate of drug nanocarriers. Adv Drug Deliv Rev. 2019 Jan 10. PMID: 30639257.
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    4. Jarvis M, Krishnan V, Mitragotri S. Nanocrystals: A perspective on translational research and clinical studies. Bioeng Transl Med. 2019 Jan; 4(1):5-16. PMID: 30680314.
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    5. Pusuluri A, Krishnan V, Lensch V, Sarode A, Bunyan E, Vogus DR, Menegatti S, Soh HT, Mitragotri S. Treating Tumors at Low Drug Doses Using an Aptamer-Peptide Synergistic Drug Conjugate. Angew Chem Int Ed Engl. 2018 Dec 11. PMID: 30537284.
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    6. Anselmo AC, Gokarn Y, Mitragotri S. Non-invasive delivery strategies for biologics. Nat Rev Drug Discov. 2018 Nov 30. PMID: 30498202.
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    7. Banerjee A, Ibsen K, Brown T, Chen R, Agatemor C, Mitragotri S. Reply to Rogers and Gurau: Definitions of ionic liquids and deep eutectic solvents. Proc Natl Acad Sci U S A. 2018 11 20; 115(47):E11000-E11001. PMID: 30401740.
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    8. Vaidya B, Parvathaneni V, Kulkarni NS, Shukla SK, Damon JK, Sarode A, Kanabar D, Garcia JV, Mitragotri S, Muth A, Gupta V. Cyclodextrin modified erlotinib loaded PLGA nanoparticles for improved therapeutic efficacy against non-small cell lung cancer. Int J Biol Macromol. 2019 Feb 01; 122:338-347. PMID: 30401652.
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    9. Kannan RM, Mitragotri S. Engineering clinical translation-Introduction to Special Issue Dedicated to 2017 Bioengineering and Translational Medicine Conference. Bioeng Transl Med. 2018 Sep; 3(3):185. PMID: 30377658.
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    10. Cooley M, Sarode A, Hoore M, Fedosov DA, Mitragotri S, Sen Gupta A. Influence of particle size and shape on their margination and wall-adhesion: implications in drug delivery vehicle design across nano-to-micro scale. Nanoscale. 2018 Aug 16; 10(32):15350-15364. PMID: 30080212.
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    11. Kannan RM, Mitragotri S. Engineering clinical translation-Introduction to Special Issue Dedicated to 2017 Bioengineering and Translational Medicine Conference. Bioeng Transl Med. 2018 May; 3(2):73. PMID: 30065962.
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    12. Tanner EEL, Ibsen KN, Mitragotri S. Transdermal insulin delivery using choline-based ionic liquids (CAGE). J Control Release. 2018 Sep 28; 286:137-144. PMID: 30026081.
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    13. Brenner JS, Pan DC, Myerson JW, Marcos-Contreras OA, Villa CH, Patel P, Hekierski H, Chatterjee S, Tao JQ, Parhiz H, Bhamidipati K, Uhler TG, Hood ED, Kiseleva RY, Shuvaev VS, Shuvaeva T, Khoshnejad M, Johnston I, Gregory JV, Lahann J, Wang T, Cantu E, Armstead WM, Mitragotri S, Muzykantov V. Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs by orders of magnitude. Nat Commun. 2018 07 11; 9(1):2684. PMID: 29992966.
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    14. Banerjee A, Ibsen K, Brown T, Chen R, Agatemor C, Mitragotri S. Ionic liquids for oral insulin delivery. Proc Natl Acad Sci U S A. 2018 07 10; 115(28):7296-7301. PMID: 29941553.
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    15. Jarvis M, Arnold M, Ott J, Krishnan V, Pant K, Prabhakarpandian B, Mitragotri S. Detachment of ligands from nanoparticle surface under flow and endothelial cell contact: Assessment using microfluidic devices. Bioeng Transl Med. 2018 May; 3(2):148-155. PMID: 30065969.
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    16. Evans MA, Huang PJ, Iwamoto Y, Ibsen KN, Chan EM, Hitomi Y, Ford PC, Mitragotri S. Macrophage-mediated delivery of light activated nitric oxide prodrugs with spatial, temporal and concentration control. Chem Sci. 2018 Apr 21; 9(15):3729-3741. PMID: 29780505.
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    17. Zhao Z, Ukidve A, Dasgupta A, Mitragotri S. Transdermal immunomodulation: Principles, advances and perspectives. Adv Drug Deliv Rev. 2018 Mar 01; 127:3-19. PMID: 29604373.
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    18. Pan DC, Myerson JW, Brenner JS, Patel PN, Anselmo AC, Mitragotri S, Muzykantov V. Nanoparticle Properties Modulate Their Attachment and Effect on Carrier Red Blood Cells. Sci Rep. 2018 01 25; 8(1):1615. PMID: 29371620.
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    19. Agatemor C, Ibsen KN, Tanner EEL, Mitragotri S. Ionic liquids for addressing unmet needs in healthcare. Bioeng Transl Med. 2018 01; 3(1):7-25. PMID: 29376130.
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    20. Vogus DR, Pusuluri A, Chen R, Mitragotri S. Schedule dependent synergy of gemcitabine and doxorubicin: Improvement of in vitro efficacy and lack of in vitro-in vivo correlation. Bioeng Transl Med. 2018 01; 3(1):49-57. PMID: 29376133.
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    21. Li D, Zhuang J, He H, Jiang S, Banerjee A, Lu Y, Wu W, Mitragotri S, Gan L, Qi J. Influence of Particle Geometry on Gastrointestinal Transit and Absorption following Oral Administration. ACS Appl Mater Interfaces. 2017 Dec 13; 9(49):42492-42502. PMID: 29148702.
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    22. Zhang M, Corona PT, Ruocco N, Alvarez D, Malo de Molina P, Mitragotri S, Helgeson ME. Controlling Complex Nanoemulsion Morphology Using Asymmetric Cosurfactants for the Preparation of Polymer Nanocapsules. Langmuir. 2018 01 23; 34(3):978-990. PMID: 29087721.
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    23. Jarvis M, Arnold M, Ott J, Pant K, Prabhakarpandian B, Mitragotri S. Microfluidic co-culture devices to assess penetration of nanoparticles into cancer cell mass. Bioeng Transl Med. 2017 09; 2(3):268-277. PMID: 29313036.
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    24. Banerjee A, Mitragotri S. Intestinal patch systems for oral drug delivery. Curr Opin Pharmacol. 2017 10; 36:58-65. PMID: 28850875.
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    25. Zhang S, Ou H, Liu C, Zhang Y, Mitragotri S, Wang D, Chen M. Skin Delivery of Hydrophilic Biomacromolecules Using Marine Sponge Spicules. Mol Pharm. 2017 09 05; 14(9):3188-3200. PMID: 28763230.
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    26. Vogus DR, Evans MA, Pusuluri A, Barajas A, Zhang M, Krishnan V, Nowak M, Menegatti S, Helgeson ME, Squires TM, Mitragotri S. A hyaluronic acid conjugate engineered to synergistically and sequentially deliver gemcitabine and doxorubicin to treat triple negative breast cancer. J Control Release. 2017 Dec 10; 267:191-202. PMID: 28823957.
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    27. Rege K, Mitragotri S. Introduction to Special Issue: 2016 Translational Medicine and Bioengineering Conference. Bioeng Transl Med. 2017 Jun; 2(2):137-138. PMID: 29313028.
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    28. Zhang M, Nowak M, Malo de Molina P, Abramovitch M, Santizo K, Mitragotri S, Helgeson ME. Synthesis of Oil-Laden Poly(ethylene glycol) Diacrylate Hydrogel Nanocapsules from Double Nanoemulsions. Langmuir. 2017 06 20; 33(24):6116-6126. PMID: 28605186.
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    29. Wibroe PP, Anselmo AC, Nilsson PH, Sarode A, Gupta V, Urbanics R, Szebeni J, Hunter AC, Mitragotri S, Mollnes TE, Moghimi SM. Bypassing adverse injection reactions to nanoparticles through shape modification and attachment to erythrocytes. Nat Nanotechnol. 2017 Jul; 12(6):589-594. PMID: 28396605.
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    30. Banerjee A, Ibsen K, Iwao Y, Zakrewsky M, Mitragotri S. Transdermal Protein Delivery Using Choline and Geranate (CAGE) Deep Eutectic Solvent. Adv Healthc Mater. 2017 Aug; 6(15). PMID: 28337858.
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    31. Banerjee A, Wong J, Gogoi R, Brown T, Mitragotri S. Intestinal micropatches for oral insulin delivery. J Drug Target. 2017 Aug; 25(7):608-615. PMID: 28266884.
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    32. Niu J, Lunn DJ, Pusuluri A, Yoo JI, O'Malley MA, Mitragotri S, Soh HT, Hawker CJ. Engineering live cell surfaces with functional polymers via cytocompatible controlled radical polymerization. Nat Chem. 2017 Jun; 9(6):537-545. PMID: 28537595.
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    33. Mitragotri S, Lammers T, Bae YH, Schwendeman S, De Smedt S, Leroux JC, Peer D, Kwon IC, Harashima H, Kikuchi A, Oh YK, Torchilin V, Hennink W, Hanes J, Park K. Drug Delivery Research for the Future: Expanding the Nano Horizons and Beyond. J Control Release. 2017 01 28; 246:183-184. PMID: 28110715.
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    34. Zakrewsky M, Mitragotri S. Therapeutic RNAi robed with ionic liquid moieties as a simple, scalable prodrug platform for treating skin disease. J Control Release. 2016 11 28; 242:80-88. PMID: 27612407.
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    35. Banerjee A, Lee J, Mitragotri S. Intestinal mucoadhesive devices for oral delivery of insulin. Bioeng Transl Med. 2016 09; 1(3):338-346. PMID: 29313019.
      View in: PubMed
    36. Banerjee A, Qi J, Gogoi R, Wong J, Mitragotri S. Role of nanoparticle size, shape and surface chemistry in oral drug delivery. J Control Release. 2016 09 28; 238:176-185. PMID: 27480450.
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    37. Decuzzi P, Mitragotri S. Introduction to special issue on "Nanoparticles in Medicine: Targeting, Optimization and Clinical Applications". Bioeng Transl Med. 2016 Mar; 1(1):8-9. PMID: 29313003.
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    38. Anselmo AC, Mitragotri S. Nanoparticles in the clinic. Bioeng Transl Med. 2016 03; 1(1):10-29. PMID: 29313004.
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    39. Mitragotri S. Letter from the Editor. Bioeng Transl Med. 2016 03; 1(1):4. PMID: 29313002.
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    40. Camacho KM, Menegatti S, Mitragotri S. Low-molecular-weight polymer-drug conjugates for synergistic anticancer activity of camptothecin and doxorubicin combinations. Nanomedicine (Lond). 2016 May; 11(9):1139-51. PMID: 27079141; PMCID: PMC4910946 [Available on 05/01/17].
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    41. Camacho KM, Menegatti S, Vogus DR, Pusuluri A, Fuchs Z, Jarvis M, Zakrewsky M, Evans MA, Chen R, Mitragotri S. DAFODIL: A novel liposome-encapsulated synergistic combination of doxorubicin and 5FU for low dose chemotherapy. J Control Release. 2016 05 10; 229:154-162. PMID: 27034194.
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    42. Pan D, Vargas-Morales O, Zern B, Anselmo AC, Gupta V, Zakrewsky M, Mitragotri S, Muzykantov V. The Effect of Polymeric Nanoparticles on Biocompatibility of Carrier Red Blood Cells. PLoS One. 2016; 11(3):e0152074. PMID: 27003833; PMCID: PMC4803339.
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    43. Zakrewsky M, Banerjee A, Apte S, Kern TL, Jones MR, Sesto RE, Koppisch AT, Fox DT, Mitragotri S. Choline and Geranate Deep Eutectic Solvent as a Broad-Spectrum Antiseptic Agent for Preventive and Therapeutic Applications. Adv Healthc Mater. 2016 06; 5(11):1282-9. PMID: 26959835.
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    44. Villa CH, Anselmo AC, Mitragotri S, Muzykantov V. Red blood cells: Supercarriers for drugs, biologicals, and nanoparticles and inspiration for advanced delivery systems. Adv Drug Deliv Rev. 2016 11 15; 106(Pt A):88-103. PMID: 26941164.
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    45. Gupta V, Hwang BH, Doshi N, Banerjee A, Anselmo AC, Mitragotri S. Delivery of Exenatide and Insulin Using Mucoadhesive Intestinal Devices. Ann Biomed Eng. 2016 06; 44(6):1993-2007. PMID: 26864536.
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    46. Menegatti S, Zakrewsky M, Kumar S, De Oliveira JS, Muraski JA, Mitragotri S. De Novo Design of Skin-Penetrating Peptides for Enhanced Transdermal Delivery of Peptide Drugs. Adv Healthc Mater. 2016 Mar 09; 5(5):602-9. PMID: 26799634.
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    47. Anselmo AC, Mitragotri S. Impact of particle elasticity on particle-based drug delivery systems. Adv Drug Deliv Rev. 2017 01 01; 108:51-67. PMID: 26806856.
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    48. Myerson JW, Anselmo AC, Liu Y, Mitragotri S, Eckmann DM, Muzykantov VR. Non-affinity factors modulating vascular targeting of nano- and microcarriers. Adv Drug Deliv Rev. 2016 Apr 01; 99(Pt A):97-112. PMID: 26596696; PMCID: PMC4798918 [Available on 04/01/17].
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    49. Kumar S, Anselmo AC, Banerjee A, Zakrewsky M, Mitragotri S. Shape and size-dependent immune response to antigen-carrying nanoparticles. J Control Release. 2015 Dec 28; 220(Pt A):141-148. PMID: 26437263.
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    50. Kumar S, Chen M, Anselmo AC, Muraski JA, Mitragotri S. Enhanced epidermal localization of topically applied steroids using SPACE™ peptide. Drug Deliv Transl Res. 2015 Oct; 5(5):523-30. PMID: 25939432.
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    51. Menegatti S, Ruocco N, Kumar S, Zakrewsky M, Sanchez De Oliveira J, Helgeson ME, Leal GL, Mitragotri S. Synthesis and characterization of a self-fluorescent hyaluronic acid-based gel for dermal applications. Adv Healthc Mater. 2015 Oct 28; 4(15):2297-305. PMID: 26371956.
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    52. Zakrewsky M, Kumar S, Mitragotri S. Nucleic acid delivery into skin for the treatment of skin disease: Proofs-of-concept, potential impact, and remaining challenges. J Control Release. 2015 Dec 10; 219:445-456. PMID: 26385169.
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    53. Anselmo AC, Kumar S, Gupta V, Pearce AM, Ragusa A, Muzykantov V, Mitragotri S. Exploiting shape, cellular-hitchhiking and antibodies to target nanoparticles to lung endothelium: Synergy between physical, chemical and biological approaches. Biomaterials. 2015 Nov; 68:1-8. PMID: 26241497.
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    54. Mitragotri S, Anderson DG, Chen X, Chow EK, Ho D, Kabanov AV, Karp JM, Kataoka K, Mirkin CA, Petrosko SH, Shi J, Stevens MM, Sun S, Teoh S, Venkatraman SS, Xia Y, Wang S, Gu Z, Xu C. Accelerating the Translation of Nanomaterials in Biomedicine. ACS Nano. 2015 Jul 28; 9(7):6644-54. PMID: 26115196.
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    55. Anselmo AC, Mitragotri S. A Review of Clinical Translation of Inorganic Nanoparticles. AAPS J. 2015 Sep; 17(5):1041-54. PMID: 25956384; PMCID: PMC4540735.
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    56. Camacho KM, Kumar S, Menegatti S, Vogus DR, Anselmo AC, Mitragotri S. Synergistic antitumor activity of camptothecin-doxorubicin combinations and their conjugates with hyaluronic acid. J Control Release. 2015 Jul 28; 210:198-207. PMID: 25921087; PMCID: PMC4470752.
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    57. Anselmo AC, Zhang M, Kumar S, Vogus DR, Menegatti S, Helgeson ME, Mitragotri S. Elasticity of nanoparticles influences their blood circulation, phagocytosis, endocytosis, and targeting. ACS Nano. 2015 Mar 24; 9(3):3169-77. PMID: 25715979.
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    58. Paithankar D, Hwang BH, Munavalli G, Kauvar A, Lloyd J, Blomgren R, Faupel L, Meyer T, Mitragotri S. Ultrasonic delivery of silica-gold nanoshells for photothermolysis of sebaceous glands in humans: Nanotechnology from the bench to clinic. J Control Release. 2015 May 28; 206:30-6. PMID: 25747145.
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    59. Mitragotri S, Hanes J. Journal of Drug Targeting Life Time Achievement Award for Prof. Robert Langer. J Drug Target. 2015; 23(7-8):579. PMID: 26453155.
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    60. Kumar S, Zakrewsky M, Chen M, Menegatti S, Muraski JA, Mitragotri S. Peptides as skin penetration enhancers: mechanisms of action. J Control Release. 2015 Feb 10; 199:168-78. PMID: 25499919.
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    61. Chen M, Kumar S, Anselmo AC, Gupta V, Slee DH, Muraski JA, Mitragotri S. Topical delivery of Cyclosporine A into the skin using SPACE-peptide. J Control Release. 2015 Feb 10; 199:190-7. PMID: 25481447.
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    62. Anselmo AC, Gilbert JB, Kumar S, Gupta V, Cohen RE, Rubner MF, Mitragotri S. Monocyte-mediated delivery of polymeric backpacks to inflamed tissues: a generalized strategy to deliver drugs to treat inflammation. J Control Release. 2015 Feb 10; 199:29-36. PMID: 25481443.
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    63. Anselmo AC, Modery-Pawlowski CL, Menegatti S, Kumar S, Vogus DR, Tian LL, Chen M, Squires TM, Sen Gupta A, Mitragotri S. Platelet-like nanoparticles: mimicking shape, flexibility, and surface biology of platelets to target vascular injuries. ACS Nano. 2014 Nov 25; 8(11):11243-53. PMID: 25318048; PMCID: PMC4246005.
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    64. Zakrewsky M, Lovejoy KS, Kern TL, Miller TE, Le V, Nagy A, Goumas AM, Iyer RS, Del Sesto RE, Koppisch AT, Fox DT, Mitragotri S. Ionic liquids as a class of materials for transdermal delivery and pathogen neutralization. Proc Natl Acad Sci U S A. 2014 Sep 16; 111(37):13313-8. PMID: 25157174; PMCID: PMC4169946.
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    65. Mitragotri S, Burke PA, Langer R. Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies. Nat Rev Drug Discov. 2014 Sep; 13(9):655-72. PMID: 25103255.
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    66. Howard M, Zern BJ, Anselmo AC, Shuvaev VV, Mitragotri S, Muzykantov V. Vascular targeting of nanocarriers: perplexing aspects of the seemingly straightforward paradigm. ACS Nano. 2014 May 27; 8(5):4100-32. PMID: 24787360; PMCID: PMC4046791.
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    67. Anselmo AC, Mitragotri S. An overview of clinical and commercial impact of drug delivery systems. J Control Release. 2014 Sep 28; 190:15-28. PMID: 24747160; PMCID: PMC4142089.
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    68. Anselmo AC, Mitragotri S. Cell-mediated delivery of nanoparticles: taking advantage of circulatory cells to target nanoparticles. J Control Release. 2014 Sep 28; 190:531-41. PMID: 24747161; PMCID: PMC4142097.
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    69. Barua S, Mitragotri S. Challenges associated with Penetration of Nanoparticles across Cell and Tissue Barriers: A Review of Current Status and Future Prospects. Nano Today. 2014 Apr 01; 9(2):223-243. PMID: 25132862.
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    70. Sarkar D, Liu W, Xie X, Anselmo AC, Mitragotri S, Banerjee K. MoS2 field-effect transistor for next-generation label-free biosensors. ACS Nano. 2014 Apr 22; 8(4):3992-4003. PMID: 24588742.
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    71. Chen M, Zakrewsky M, Gupta V, Anselmo AC, Slee DH, Muraski JA, Mitragotri S. Topical delivery of siRNA into skin using SPACE-peptide carriers. J Control Release. 2014 Apr 10; 179:33-41. PMID: 24434423; PMCID: PMC4425738.
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    72. Anselmo AC, Gupta V, Zern BJ, Pan D, Zakrewsky M, Muzykantov V, Mitragotri S. Delivering nanoparticles to lungs while avoiding liver and spleen through adsorption on red blood cells. ACS Nano. 2013 Dec 23; 7(12):11129-37. PMID: 24182189; PMCID: PMC4128963.
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    73. Chen M, Gupta V, Anselmo AC, Muraski JA, Mitragotri S. Topical delivery of hyaluronic acid into skin using SPACE-peptide carriers. J Control Release. 2014 Jan 10; 173:67-74. PMID: 24129342; PMCID: PMC4128962.
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    74. Hwang BH, Tsai KY, Mitragotri S. Optimized lysis buffer reagents for solubilization and preservation of proteins from cells and tissues. Drug Deliv Transl Res. 2013 Oct; 3(5):428-36. PMID: 25788351.
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    75. Barua S, Mitragotri S. Synergistic targeting of cell membrane, cytoplasm, and nucleus of cancer cells using rod-shaped nanoparticles. ACS Nano. 2013 Nov 26; 7(11):9558-70. PMID: 24053162; PMCID: PMC4128961.
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    76. Gupta V, Hwang BH, Lee J, Anselmo AC, Doshi N, Mitragotri S. Mucoadhesive intestinal devices for oral delivery of salmon calcitonin. J Control Release. 2013 Dec 28; 172(3):753-62. PMID: 24035976.
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    77. Mitragotri S. Engineering approaches to transdermal drug delivery: a tribute to contributions of prof. Robert Langer. Skin Pharmacol Physiol. 2013; 26(4-6):263-76. PMID: 23921113.
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    78. Kolhar P, Anselmo AC, Gupta V, Pant K, Prabhakarpandian B, Ruoslahti E, Mitragotri S. Using shape effects to target antibody-coated nanoparticles to lung and brain endothelium. Proc Natl Acad Sci U S A. 2013 Jun 25; 110(26):10753-8. PMID: 23754411; PMCID: PMC3696781.
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    79. Gupta V, Hwang BH, Doshi N, Mitragotri S. A permeation enhancer for increasing transport of therapeutic macromolecules across the intestine. J Control Release. 2013 Dec 10; 172(2):541-9. PMID: 23680288.
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    80. Bao G, Mitragotri S, Tong S. Multifunctional nanoparticles for drug delivery and molecular imaging. Annu Rev Biomed Eng. 2013; 15:253-82. PMID: 23642243.
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    81. Zhou Z, Anselmo AC, Mitragotri S. Synthesis of protein-based, rod-shaped particles from spherical templates using layer-by-layer assembly. Adv Mater. 2013 May 21; 25(19):2723-7. PMID: 23580475.
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    82. Gupta V, Doshi N, Mitragotri S. Permeation of insulin, calcitonin and exenatide across Caco-2 monolayers: measurement using a rapid, 3-day system. PLoS One. 2013; 8(2):e57136. PMID: 23483881; PMCID: PMC3586668.
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    83. Barua S, Yoo JW, Kolhar P, Wakankar A, Gokarn YR, Mitragotri S. Particle shape enhances specificity of antibody-displaying nanoparticles. Proc Natl Acad Sci U S A. 2013 Feb 26; 110(9):3270-5. PMID: 23401509; PMCID: PMC3587278.
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    84. Pino CJ, Gutterman JU, Vonwil D, Mitragotri S, Shastri VP. Glycosylation facilitates transdermal transport of macromolecules. Proc Natl Acad Sci U S A. 2012 Dec 26; 109(52):21283-8. PMID: 23236155; PMCID: PMC3535623.
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    85. Paliwal S, Hwang BH, Tsai KY, Mitragotri S. Diagnostic opportunities based on skin biomarkers. Eur J Pharm Sci. 2013 Dec 18; 50(5):546-56. PMID: 23159445.
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    86. Modery-Pawlowski CL, Tian LL, Pan V, McCrae KR, Mitragotri S, Sen Gupta A. Approaches to synthetic platelet analogs. Biomaterials. 2013 Jan; 34(2):526-41. PMID: 23092864.
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    87. Hwang BH, Doshi N, Tsai KY, Mitragotri S. A reagent to facilitate protein recovery from cells and tissues. Drug Deliv Transl Res. 2012 Oct; 2(5):297-304. PMID: 25787172.
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    88. Lee KJ, Yoon J, Rahmani S, Hwang S, Bhaskar S, Mitragotri S, Lahann J. Spontaneous shape reconfigurations in multicompartmental microcylinders. Proc Natl Acad Sci U S A. 2012 Oct 02; 109(40):16057-62. PMID: 22992652; PMCID: PMC3479567.
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    89. Mitragotri S. Devices for overcoming biological barriers: the use of physical forces to disrupt the barriers. Adv Drug Deliv Rev. 2013 Jan; 65(1):100-3. PMID: 22960787.
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    90. Mitragotri S, Lahann J. Materials for drug delivery: innovative solutions to address complex biological hurdles. Adv Mater. 2012 Jul 24; 24(28):3717-23. PMID: 22807037.
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    91. Doshi N, Orje JN, Molins B, Smith JW, Mitragotri S, Ruggeri ZM. Platelet mimetic particles for targeting thrombi in flowing blood. Adv Mater. 2012 Jul 24; 24(28):3864-9. PMID: 22641451; PMCID: PMC3483800.
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    92. Pangarkar C, Dinh AT, Mitragotri S. Endocytic pathway rapidly delivers internalized molecules to lysosomes: an analysis of vesicle trafficking, clustering and mass transfer. J Control Release. 2012 Aug 20; 162(1):76-83. PMID: 22609352.
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    93. Ogura M, Paliwal S, Mitragotri S. Sampling of disease biomarkers from skin for theranostic applications. Drug Deliv Transl Res. 2012 Apr; 2(2):87-94. PMID: 25786717.
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    94. Kirch J, Guenther M, Doshi N, Schaefer UF, Schneider M, Mitragotri S, Lehr CM. Mucociliary clearance of micro- and nanoparticles is independent of size, shape and charge--an ex vivo and in silico approach. J Control Release. 2012 Apr 10; 159(1):128-34. PMID: 22226774.
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    95. Mitragotri S, Yoo JW. Designing micro- and nano-particles for treating rheumatoid arthritis. Arch Pharm Res. 2011 Nov; 34(11):1887-97. PMID: 22139688.
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    96. Hsu T, Mitragotri S. Delivery of siRNA and other macromolecules into skin and cells using a peptide enhancer. Proc Natl Acad Sci U S A. 2011 Sep 20; 108(38):15816-21. PMID: 21903933; PMCID: PMC3179050.
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    97. Yoo JW, Irvine DJ, Discher DE, Mitragotri S. Bio-inspired, bioengineered and biomimetic drug delivery carriers. Nat Rev Drug Discov. 2011 Jul 01; 10(7):521-35. PMID: 21720407.
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    98. Kolhar P, Doshi N, Mitragotri S. Polymer nanoneedle-mediated intracellular drug delivery. Small. 2011 Jul 18; 7(14):2094-100. PMID: 21695782.
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    99. Yoo JW, Doshi N, Mitragotri S. Adaptive micro and nanoparticles: temporal control over carrier properties to facilitate drug delivery. Adv Drug Deliv Rev. 2011 Nov; 63(14-15):1247-56. PMID: 21605607.
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    100. Michinaka Y, Mitragotri S. Delivery of polymeric particles into skin using needle-free liquid jet injectors. J Control Release. 2011 Aug 10; 153(3):249-54. PMID: 21457734.
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    101. Doshi N, Swiston AJ, Gilbert JB, Alcaraz ML, Cohen RE, Rubner MF, Mitragotri S. Cell-based drug delivery devices using phagocytosis-resistant backpacks. Adv Mater. 2011 Mar 25; 23(12):H105-9. PMID: 21365691.
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    102. Mitragotri S, Anissimov YG, Bunge AL, Frasch HF, Guy RH, Hadgraft J, Kasting GB, Lane ME, Roberts MS. Mathematical models of skin permeability: an overview. Int J Pharm. 2011 Oct 10; 418(1):115-29. PMID: 21356301.
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    103. James-Smith MA, Hellner B, Annunziato N, Mitragotri S. Effect of surfactant mixtures on skin structure and barrier properties. Ann Biomed Eng. 2011 Apr; 39(4):1215-23. PMID: 21063778; PMCID: PMC3069307.
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    104. Sharma G, Valenta DT, Altman Y, Harvey S, Xie H, Mitragotri S, Smith JW. Polymer particle shape independently influences binding and internalization by macrophages. J Control Release. 2010 Nov 01; 147(3):408-12. PMID: 20691741; PMCID: PMC2975856.
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    105. Paliwal S, Ogura M, Mitragotri S. One-step acquisition of functional biomolecules from tissues. Proc Natl Acad Sci U S A. 2010 Aug 17; 107(33):14627-32. PMID: 20679248; PMCID: PMC2930427.
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    106. Yoo JW, Chambers E, Mitragotri S. Factors that control the circulation time of nanoparticles in blood: challenges, solutions and future prospects. Curr Pharm Des. 2010 Jul; 16(21):2298-307. PMID: 20618151.
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    107. Yoo JW, Mitragotri S. Polymer particles that switch shape in response to a stimulus. Proc Natl Acad Sci U S A. 2010 Jun 22; 107(25):11205-10. PMID: 20547873; PMCID: PMC2895097.
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    108. Liu Y, Paliwal S, Bankiewicz KS, Bringas JR, Heart G, Mitragotri S, Prausnitz MR. Ultrasound-enhanced drug transport and distribution in the brain. AAPS PharmSciTech. 2010 Sep; 11(3):1005-17. PMID: 20532711; PMCID: PMC2974134.
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    109. Doshi N, Mitragotri S. Needle-shaped polymeric particles induce transient disruption of cell membranes. J R Soc Interface. 2010 Aug 06; 7 Suppl 4:S403-10. PMID: 20504803; PMCID: PMC2943891.
      View in: PubMed, PubMed Central
    110. Doshi N, Prabhakarpandian B, Rea-Ramsey A, Pant K, Sundaram S, Mitragotri S. Flow and adhesion of drug carriers in blood vessels depend on their shape: a study using model synthetic microvascular networks. J Control Release. 2010 Sep 01; 146(2):196-200. PMID: 20385181; PMCID: PMC4128960.
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    111. Doshi N, Mitragotri S. Macrophages recognize size and shape of their targets. PLoS One. 2010 Apr 06; 5(4):e10051. PMID: 20386614; PMCID: PMC2850372.
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    112. Arora A, Mitragotri S. Novel topical microbicides through combinatorial strategies. Pharm Res. 2010 Jul; 27(7):1264-72. PMID: 20306119; PMCID: PMC2883926.
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    113. Paliwal S, Ogura M, Mitragotri S. Rapid sampling of molecules via skin for diagnostic and forensic applications. Pharm Res. 2010 Jul; 27(7):1255-63. PMID: 20238151; PMCID: PMC2883922.
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    114. Arora A, Kisak E, Karande P, Newsam J, Mitragotri S. Multicomponent chemical enhancer formulations for transdermal drug delivery: more is not always better. J Control Release. 2010 Jun 01; 144(2):175-80. PMID: 20153789.
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    115. Karande P, Mitragotri S. Transcutaneous immunization: an overview of advantages, disease targets, vaccines, and delivery technologies. Annu Rev Chem Biomol Eng. 2010; 1:175-201. PMID: 22432578.
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    116. Doshi N, Zahr AS, Bhaskar S, Lahann J, Mitragotri S. Red blood cell-mimicking synthetic biomaterial particles. Proc Natl Acad Sci U S A. 2009 Dec 22; 106(51):21495-9. PMID: 20018694; PMCID: PMC2799852.
      View in: PubMed, PubMed Central
    117. Yoo JW, Doshi N, Mitragotri S. Endocytosis and Intracellular Distribution of PLGA Particles in Endothelial Cells: Effect of Particle Geometry. Macromol Rapid Commun. 2010 Jan 18; 31(2):142-8. PMID: 21590886.
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    118. Karande P, Mitragotri S. Enhancement of transdermal drug delivery via synergistic action of chemicals. Biochim Biophys Acta. 2009 Nov; 1788(11):2362-73. PMID: 19733150.
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    119. Karande P, Arora A, Pham TK, Stevens D, Wojicki A, Mitragotri S. Transcutaneous immunization using common chemicals. J Control Release. 2009 Sep 01; 138(2):134-40. PMID: 19426770.
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    120. Stachowiak JC, Li TH, Arora A, Mitragotri S, Fletcher DA. Dynamic control of needle-free jet injection. J Control Release. 2009 Apr 17; 135(2):104-12. PMID: 19284969.
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    121. Mitragotri S, Lahann J. Physical approaches to biomaterial design. Nat Mater. 2009 Jan; 8(1):15-23. PMID: 19096389; PMCID: PMC2793340.
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    122. Mitragotri S. In drug delivery, shape does matter. Pharm Res. 2009 Jan; 26(1):232-4. PMID: 18923811.
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    123. Arora A, Prausnitz MR, Mitragotri S. Micro-scale devices for transdermal drug delivery. Int J Pharm. 2008 Dec 08; 364(2):227-36. PMID: 18805472; PMCID: PMC2752650.
      View in: PubMed, PubMed Central
    124. Muro S, Garnacho C, Champion JA, Leferovich J, Gajewski C, Schuchman EH, Mitragotri S, Muzykantov VR. Control of endothelial targeting and intracellular delivery of therapeutic enzymes by modulating the size and shape of ICAM-1-targeted carriers. Mol Ther. 2008 Aug; 16(8):1450-8. PMID: 18560419; PMCID: PMC2810502.
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    125. Champion JA, Mitragotri S. Shape induced inhibition of phagocytosis of polymer particles. Pharm Res. 2009 Jan; 26(1):244-9. PMID: 18548338; PMCID: PMC2810499.
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    126. Whitehead K, Mitragotri S. Mechanistic analysis of chemical permeation enhancers for oral drug delivery. Pharm Res. 2008 Jun; 25(6):1412-9. PMID: 18311478.
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    127. Ogura M, Paliwal S, Mitragotri S. Low-frequency sonophoresis: current status and future prospects. Adv Drug Deliv Rev. 2008 Jun 30; 60(10):1218-23. PMID: 18450318.
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    128. Champion JA, Walker A, Mitragotri S. Role of particle size in phagocytosis of polymeric microspheres. Pharm Res. 2008 Aug; 25(8):1815-21. PMID: 18373181; PMCID: PMC2793372.
      View in: PubMed, PubMed Central
    129. Whitehead K, Karr N, Mitragotri S. Discovery of synergistic permeation enhancers for oral drug delivery. J Control Release. 2008 Jun 04; 128(2):128-33. PMID: 18433909.
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    130. Paliwal S, Mitragotri S. Therapeutic opportunities in biological responses of ultrasound. Ultrasonics. 2008 Aug; 48(4):271-8. PMID: 18406440.
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    131. Whitehead K, Karr N, Mitragotri S. Safe and effective permeation enhancers for oral drug delivery. Pharm Res. 2008 Aug; 25(8):1782-8. PMID: 18058001.
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    132. Champion JA, Katare YK, Mitragotri S. Making polymeric micro- and nanoparticles of complex shapes. Proc Natl Acad Sci U S A. 2007 Jul 17; 104(29):11901-4. PMID: 17620615; PMCID: PMC1924596.
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    133. Chambers E, Mitragotri S. Long circulating nanoparticles via adhesion on red blood cells: mechanism and extended circulation. Exp Biol Med (Maywood). 2007 Jul; 232(7):958-66. PMID: 17609513.
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    134. Mitragotri S. Temperature dependence of skin permeability to hydrophilic and hydrophobic solutes. J Pharm Sci. 2007 Jul; 96(7):1832-9. PMID: 17094128.
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    135. Hall SS, Mitragotri S, Daugherty PS. Identification of peptide ligands facilitating nanoparticle attachment to erythrocytes. Biotechnol Prog. 2007 May-Jun; 23(3):749-54. PMID: 17469847.
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    136. Champion JA, Katare YK, Mitragotri S. Particle shape: a new design parameter for micro- and nanoscale drug delivery carriers. J Control Release. 2007 Aug 16; 121(1-2):3-9. PMID: 17544538; PMCID: PMC4009069.
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    137. Arora A, Hakim I, Baxter J, Rathnasingham R, Srinivasan R, Fletcher DA, Mitragotri S. Needle-free delivery of macromolecules across the skin by nanoliter-volume pulsed microjets. Proc Natl Acad Sci U S A. 2007 Mar 13; 104(11):4255-60. PMID: 17360511; PMCID: PMC1838589.
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    138. Karande P, Jain A, Arora A, Ho MJ, Mitragotri S. Synergistic effects of chemical enhancers on skin permeability: a case study of sodium lauroylsarcosinate and sorbitan monolaurate. Eur J Pharm Sci. 2007 May; 31(1):1-7. PMID: 17368869.
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    139. Dinh AT, Pangarkar C, Theofanous T, Mitragotri S. Understanding intracellular transport processes pertinent to synthetic gene delivery via stochastic simulations and sensitivity analyses. Biophys J. 2007 Feb 01; 92(3):831-46. PMID: 17085500; PMCID: PMC1779970.
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    140. Paliwal S, Mitragotri S. Ultrasound-induced cavitation: applications in drug and gene delivery. Expert Opin Drug Deliv. 2006 Nov; 3(6):713-26. PMID: 17076594.
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    141. Baxter J, Mitragotri S. Needle-free liquid jet injections: mechanisms and applications. Expert Rev Med Devices. 2006 Sep; 3(5):565-74. PMID: 17064242.
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    142. Dinh AT, Theofanous T, Mitragotri S. Modeling of pattern regulation in melanophores. J Theor Biol. 2007 Jan 07; 244(1):141-53. PMID: 16959269.
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    143. Karande P, Jain A, Mitragotri S. Insights into synergistic interactions in binary mixtures of chemical permeation enhancers for transdermal drug delivery. J Control Release. 2006 Sep 28; 115(1):85-93. PMID: 16935378.
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    144. Mitragotri S. Current status and future prospects of needle-free liquid jet injectors. Nat Rev Drug Discov. 2006 07; 5(7):543-8. PMID: 16816837.
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    145. Paliwal S, Menon GK, Mitragotri S. Low-frequency sonophoresis: ultrastructural basis for stratum corneum permeability assessed using quantum dots. J Invest Dermatol. 2006 May; 126(5):1095-101. PMID: 16528354.
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    146. Dinh AT, Pangarkar C, Theofanous T, Mitragotri S. Theory of spatial patterns of intracellular organelles. Biophys J. 2006 May 15; 90(10):L67-9. PMID: 16565038; PMCID: PMC1440763.
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    147. Champion JA, Mitragotri S. Role of target geometry in phagocytosis. Proc Natl Acad Sci U S A. 2006 Mar 28; 103(13):4930-4. PMID: 16549762; PMCID: PMC1458772.
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    148. Lee PJ, Ahmad N, Langer R, Mitragotri S, Prasad Shastri V. Evaluation of chemical enhancers in the transdermal delivery of lidocaine. Int J Pharm. 2006 Feb 03; 308(1-2):33-9. PMID: 16321488.
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    149. Mitragotri S. Immunization without needles. Nat Rev Immunol. 2005 12; 5(12):905-16. PMID: 16239901.
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    150. Karande P, Jain A, Mitragotri S. Relationships between skin's electrical impedance and permeability in the presence of chemical enhancers. J Control Release. 2006 Jan 10; 110(2):307-13. PMID: 16313994.
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    151. Pangarkar C, Dinh AT, Mitragotri S. Dynamics and spatial organization of endosomes in mammalian cells. Phys Rev Lett. 2005 Oct 07; 95(15):158101. PMID: 16241764.
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    152. Baxter J, Mitragotri S. Jet-induced skin puncture and its impact on needle-free jet injections: experimental studies and a predictive model. J Control Release. 2005 Sep 02; 106(3):361-73. PMID: 16002174.
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    153. Dinh AT, Theofanous T, Mitragotri S. A model for intracellular trafficking of adenoviral vectors. Biophys J. 2005 Sep; 89(3):1574-88. PMID: 15980163; PMCID: PMC1366662.
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    154. Karande P, Jain A, Ergun K, Kispersky V, Mitragotri S. Design principles of chemical penetration enhancers for transdermal drug delivery. Proc Natl Acad Sci U S A. 2005 Mar 29; 102(13):4688-93. PMID: 15774584; PMCID: PMC555729.
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    155. Tezel A, Paliwal S, Shen Z, Mitragotri S. Low-frequency ultrasound as a transcutaneous immunization adjuvant. Vaccine. 2005 May 31; 23(29):3800-7. PMID: 15893617.
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    156. Mitragotri S. Healing sound: the use of ultrasound in drug delivery and other therapeutic applications. Nat Rev Drug Discov. 2005 Mar; 4(3):255-60. PMID: 15738980.
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    157. Tezel A, Dokka S, Kelly S, Hardee GE, Mitragotri S. Topical delivery of anti-sense oligonucleotides using low-frequency sonophoresis. Pharm Res. 2004 Dec; 21(12):2219-25. PMID: 15648253.
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    158. Chambers E, Mitragotri S. Prolonged circulation of large polymeric nanoparticles by non-covalent adsorption on erythrocytes. J Control Release. 2004 Nov 05; 100(1):111-9. PMID: 15491815.
      View in: PubMed
    159. Mitragotri S. Sonophoresis: a 50-year journey. Drug Discov Today. 2004 Sep 01; 9(17):735-6. PMID: 15450237.
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    160. Schramm-Baxter J, Katrencik J, Mitragotri S. Jet injection into polyacrylamide gels: investigation of jet injection mechanics. J Biomech. 2004 Aug; 37(8):1181-8. PMID: 15212923.
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    161. Whitehead K, Shen Z, Mitragotri S. Oral delivery of macromolecules using intestinal patches: applications for insulin delivery. J Control Release. 2004 Jul 23; 98(1):37-45. PMID: 15245887.
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    162. Schramm-Baxter J, Mitragotri S. Needle-free jet injections: dependence of jet penetration and dispersion in the skin on jet power. J Control Release. 2004 Jul 07; 97(3):527-35. PMID: 15212884.
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    163. Mitragotri S. Breaking the skin barrier. Adv Drug Deliv Rev. 2004 Mar 27; 56(5):555-6. PMID: 15019744.
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    164. Mitragotri S, Kost J. Low-frequency sonophoresis: a review. Adv Drug Deliv Rev. 2004 Mar 27; 56(5):589-601. PMID: 15019748.
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    165. Prausnitz MR, Mitragotri S, Langer R. Current status and future potential of transdermal drug delivery. Nat Rev Drug Discov. 2004 Feb; 3(2):115-24. PMID: 15040576.
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    166. Karande P, Jain A, Mitragotri S. Discovery of transdermal penetration enhancers by high-throughput screening. Nat Biotechnol. 2004 Feb; 22(2):192-7. PMID: 14704682.
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    167. Tezel A, Mitragotri S. Interactions of inertial cavitation bubbles with stratum corneum lipid bilayers during low-frequency sonophoresis. Biophys J. 2003 Dec; 85(6):3502-12. PMID: 14645045; PMCID: PMC1303657.
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    168. Sundaram J, Mellein BR, Mitragotri S. An experimental and theoretical analysis of ultrasound-induced permeabilization of cell membranes. Biophys J. 2003 May; 84(5):3087-101. PMID: 12719239; PMCID: PMC1302870.
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    169. Karande P, Mitragotri S. Dependence of skin permeability on contact area. Pharm Res. 2003 Feb; 20(2):257-63. PMID: 12636165.
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    170. Tezel A, Sens A, Mitragotri S. Description of transdermal transport of hydrophilic solutes during low-frequency sonophoresis based on a modified porous pathway model. J Pharm Sci. 2003 Feb; 92(2):381-93. PMID: 12532387.
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    171. Lahann J, Mitragotri S, Tran TN, Kaido H, Sundaram J, Choi IS, Hoffer S, Somorjai GA, Langer R. A reversibly switching surface. Science. 2003 Jan 17; 299(5605):371-4. PMID: 12532011.
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    172. Mitragotri S. Modeling skin permeability to hydrophilic and hydrophobic solutes based on four permeation pathways. J Control Release. 2003 Jan 09; 86(1):69-92. PMID: 12490374.
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    173. Tezel A, Mitragotri S. On the origin of size-dependent tortuosity for permeation of hydrophilic solutes across the stratum corneum. J Control Release. 2003 Jan 09; 86(1):183-6. PMID: 12490383.
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    174. Tezel A, Sens A, Mitragotri S. A theoretical analysis of low-frequency sonophoresis: dependence of transdermal transport pathways on frequency and energy density. Pharm Res. 2002 Dec; 19(12):1841-6. PMID: 12523663.
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    175. Schramm J, Mitragotri S. Transdermal drug delivery by jet injectors: energetics of jet formation and penetration. Pharm Res. 2002 Nov; 19(11):1673-9. PMID: 12458673.
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    176. Tezel A, Sens A, Mitragotri S. Incorporation of lipophilic pathways into the porous pathway model for describing skin permeabilization during low-frequency sonophoresis. J Control Release. 2002 Sep 18; 83(1):183-8. PMID: 12220849.
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    177. Karande P, Mitragotri S. High throughput screening of transdermal formulations. Pharm Res. 2002 May; 19(5):655-60. PMID: 12069169.
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    178. Mitragotri S. A theoretical analysis of permeation of small hydrophobic solutes across the stratum corneum based on Scaled Particle Theory. J Pharm Sci. 2002 Mar; 91(3):744-52. PMID: 11920759.
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    179. Terahara T, Mitragotri S, Langer R. Porous resins as a cavitation enhancer for low-frequency sonophoresis. J Pharm Sci. 2002 Mar; 91(3):753-9. PMID: 11920760.
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    180. Tezel A, Sens A, Mitragotri S. Investigations of the role of cavitation in low-frequency sonophoresis using acoustic spectroscopy. J Pharm Sci. 2002 Feb; 91(2):444-53. PMID: 11835204.
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    181. Tezel A, Sens A, Tuchscherer J, Mitragotri S. Synergistic effect of low-frequency ultrasound and surfactants on skin permeability. J Pharm Sci. 2002 Jan; 91(1):91-100. PMID: 11782900.
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    182. Mitragotri S, Kost J. Transdermal delivery of heparin and low-molecular weight heparin using low-frequency ultrasound. Pharm Res. 2001 Aug; 18(8):1151-6. PMID: 11587487.
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    183. Mitragotri S. Effect of bilayer distruption on transdermal transport of low-molecular weight hydrophobic solutes. Pharm Res. 2001 Jul; 18(7):1018-23. PMID: 11496939.
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    184. Mitragotri S. Effect of therapeutic ultrasound on partition and diffusion coefficients in human stratum corneum. J Control Release. 2001 Mar 12; 71(1):23-9. PMID: 11245905.
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    185. Mitragotri S. Synergistic effect of enhancers for transdermal drug delivery. Pharm Res. 2000 Nov; 17(11):1354-9. PMID: 11205727.
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    186. Mitragotri S, Coleman M, Kost J, Langer R. Analysis of ultrasonically extracted interstitial fluid as a predictor of blood glucose levels. J Appl Physiol (1985). 2000 Sep; 89(3):961-6. PMID: 10956339.
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    187. Mitragotri S. In situ determination of partition and diffusion coefficients in the lipid bilayers of stratum corneum. Pharm Res. 2000 Aug; 17(8):1026-9. PMID: 11028952.
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    188. Mitragotri S, Ray D, Farrell J, Tang H, Yu B, Kost J, Blankschtein D, Langer R. Synergistic effect of low-frequency ultrasound and sodium lauryl sulfate on transdermal transport. J Pharm Sci. 2000 Jul; 89(7):892-900. PMID: 10861590.
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    189. Mitragotri S, Kost J. Low-frequency sonophoresis: a noninvasive method of drug delivery and diagnostics. Biotechnol Prog. 2000 May-Jun; 16(3):488-92. PMID: 10835253.
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    190. Mitragotri S, Coleman M, Kost J, Langer R. Transdermal extraction of analytes using low-frequency ultrasound. Pharm Res. 2000 Apr; 17(4):466-70. PMID: 10870992.
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