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Melmed Shlomo K

Title(s)Vice President, Academic Affairs
SchoolCedar-Sinai Medical Center
Phone310-423-4691
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    Other Positions
    Title(s)Director, Clinical Research Institute

    Title(s)Associate Dean, Medicine


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Melmed S. Pathogenesis and Diagnosis of Growth Hormone Deficiency in Adults. N Engl J Med. 2019 06 27; 380(26):2551-2562. PMID: 31242363.
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    2. Chesnokova V, Zonis S, Barrett RJ, Gleeson JP, Melmed S. Growth Hormone Induces Colon DNA Damage Independent of IGF-1. Endocrinology. 2019 Jun 01; 160(6):1439-1447. PMID: 31002310.
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    3. Colao A, Grasso LFS, Giustina A, Melmed S, Chanson P, Pereira AM, Pivonello R. Acromegaly. Nat Rev Dis Primers. 2019 03 21; 5(1):20. PMID: 30899019.
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    4. Chesnokova V, Zonis S, Barrett R, Kameda H, Wawrowsky K, Ben-Shlomo A, Yamamoto M, Gleeson J, Bresee C, Gorbunova V, Melmed S. Excess growth hormone suppresses DNA damage repair in epithelial cells. JCI Insight. 2019 Feb 07; 4(3). PMID: 30728323.
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    5. Kameda H, Yamamoto M, Tone Y, Tone M, Melmed S. Proton Sensitivity of Corticotropin-Releasing Hormone Receptor 1 Signaling to Proopiomelanocortin in Male Mice. Endocrinology. 2019 Feb 01; 160(2):276-291. PMID: 30535142.
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    6. Casanueva FF, Barkan AL, Buchfelder M, Klibanski A, Laws ER, Loeffler JS, Melmed S, Mortini P, Wass J, Giustina A. Correction to: Criteria for the definition of Pituitary Tumor Centers of Excellence (PTCOE): A Pituitary Society Statement. Pituitary. 2018 12; 21(6):663. PMID: 30238283.
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    7. Yamamoto M, Ben-Shlomo A, Kameda H, Fukuoka H, Deng N, Ding Y, Melmed S. Somatostatin receptor subtype 5 modifies hypothalamic-pituitary-adrenal axis stress function. JCI Insight. 2018 10 04; 3(19). PMID: 30282821.
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    8. Günther T, Tulipano G, Dournaud P, Bousquet C, Csaba Z, Kreienkamp HJ, Lupp A, Korbonits M, Castaño JP, Wester HJ, Culler M, Melmed S, Schulz S. International Union of Basic and Clinical Pharmacology. CV. Somatostatin Receptors: Structure, Function, Ligands, and New Nomenclature. Pharmacol Rev. 2018 10; 70(4):763-835. PMID: 30232095.
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    9. Melmed S, Bronstein MD, Chanson P, Klibanski A, Casanueva FF, Wass JAH, Strasburger CJ, Luger A, Clemmons DR, Giustina A. A Consensus Statement on acromegaly therapeutic outcomes. Nat Rev Endocrinol. 2018 Sep; 14(9):552-561. PMID: 30050156.
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    10. Casanueva FF, Barkan AL, Buchfelder M, Klibanski A, Laws ER, Loeffler JS, Melmed S, Mortini P, Wass J, Giustina A. Criteria for the definition of Pituitary Tumor Centers of Excellence (PTCOE): A Pituitary Society Statement. Pituitary. 2017 Oct; 20(5):489-498. PMID: 28884415.
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    11. Babu H, Ortega A, Nuno M, Dehghan A, Schweitzer A, Bonert HV, Carmichael JD, Cooper O, Melmed S, Mamelak AN. Long-Term Endocrine Outcomes Following Endoscopic Endonasal Transsphenoidal Surgery for Acromegaly and Associated Prognostic Factors. Neurosurgery. 2017 Aug 01; 81(2):357-366. PMID: 28368500.
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    12. Recouvreux MV, Wu JB, Gao AC, Zonis S, Chesnokova V, Bhowmick N, Chung LW, Melmed S. Androgen Receptor Regulation of Local Growth Hormone in Prostate Cancer Cells. Endocrinology. 2017 07 01; 158(7):2255-2268. PMID: 28444169.
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    13. Melmed S. Melvin M. Grumbach 1925-2016. Proc Natl Acad Sci U S A. 2017 05 09; 114(19):4845-4847. PMID: 28439029.
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    14. Cooper O, Bonert V, Moser F, Mirocha J, Melmed S. Altered Pituitary Gland Structure and Function in Posttraumatic Stress Disorder. J Endocr Soc. 2017 Jun 01; 1(6):577-587. PMID: 29264511.
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    15. Ben-Shlomo A, Liu NA, Melmed S. Somatostatin and dopamine receptor regulation of pituitary somatotroph adenomas. Pituitary. 2017 Feb; 20(1):93-99. PMID: 27900635.
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    16. Araki T, Liu X, Kameda H, Tone Y, Fukuoka H, Tone M, Melmed S. EGFR Induces E2F1-Mediated Corticotroph Tumorigenesis. J Endocr Soc. 2017 Feb 01; 1(2):127-143. PMID: 29264472.
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    17. Fleseriu M, Hashim IA, Karavitaki N, Melmed S, Murad MH, Salvatori R, Samuels MH. Hormonal Replacement in Hypopituitarism in Adults: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2016 Nov; 101(11):3888-3921. PMID: 27736313.
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    18. Araki T, Liu NA, Tone Y, Cuevas-Ramos D, Heltsley R, Tone M, Melmed S. E2F1-mediated human POMC expression in ectopic Cushing's syndrome. Endocr Relat Cancer. 2016 11; 23(11):857-870. PMID: 27935805.
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    19. Chesnokova V, Zonis S, Zhou C, Recouvreux MV, Ben-Shlomo A, Araki T, Barrett R, Workman M, Wawrowsky K, Ljubimov VA, Uhart M, Melmed S. Growth hormone is permissive for neoplastic colon growth. Proc Natl Acad Sci U S A. 2016 Jun 07; 113(23):E3250-9. PMID: 27226307; PMCID: PMC4988562 [Available on 12/07/16].
    20. Christiansen JS, Backeljauw PF, Bidlingmaier M, Biller BM, Boguszewski MC, Casanueva FF, Chanson P, Chatelain P, Choong CS, Clemmons DR, Cohen LE, Cohen P, Frystyk J, Grimberg A, Hasegawa Y, Haymond MW, Ho K, Hoffman AR, Holly JM, Horikawa R, Höybye C, Jorgensen JO, Johannsson G, Juul A, Katznelson L, Kopchick JJ, Lee KO, Lee KW, Luo X, Melmed S, Miller BS, Misra M, Popovic V, Rosenfeld RG, Ross J, Ross RJ, Saenger P, Strasburger CJ, Thorner MO, Werner H, Yuen K. Growth Hormone Research Society perspective on the development of long-acting growth hormone preparations. Eur J Endocrinol. 2016 Jun; 174(6):C1-8. PMID: 27009113.
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    21. Melmed S. Pituitary Medicine From Discovery to Patient-Focused Outcomes. J Clin Endocrinol Metab. 2016 Mar; 101(3):769-77. PMID: 26908107.
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    22. Giustina A, Bevan JS, Bronstein MD, Casanueva FF, Chanson P, Petersenn S, Thanh XM, Sert C, Houchard A, Guillemin I, Melmed S. SAGIT®: clinician-reported outcome instrument for managing acromegaly in clinical practice--development and results from a pilot study. Pituitary. 2016 Feb; 19(1):39-49. PMID: 26377024; PMCID: PMC4710645.
    23. Melmed S. New therapeutic agents for acromegaly. Nat Rev Endocrinol. 2016 Feb; 12(2):90-8. PMID: 26610414.
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    24. Herold KC, Majzoub JA, Melmed S, Pendergrass M, Schlumberger M. Endocrinology research-reflecting on the past decade and looking to the next. Nat Rev Endocrinol. 2015 Nov; 11(11):672-80. PMID: 26460340.
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    25. Melmed S. Fertility and fragrance: another cause of Kallmann syndrome. J Clin Invest. 2015 Jun; 125(6):2275-8. PMID: 25985271; PMCID: PMC4497770.
    26. Liu NA, Araki T, Cuevas-Ramos D, Hong J, Ben-Shlomo A, Tone Y, Tone M, Melmed S. Cyclin E-Mediated Human Proopiomelanocortin Regulation as a Therapeutic Target for Cushing Disease. J Clin Endocrinol Metab. 2015 Jul; 100(7):2557-64. PMID: 25942479.
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    27. Zhou C, Jiao Y, Wang R, Ren SG, Wawrowsky K, Melmed S. STAT3 upregulation in pituitary somatotroph adenomas induces growth hormone hypersecretion. J Clin Invest. 2015 Apr; 125(4):1692-702. PMID: 25774503; PMCID: PMC4396466.
    28. Melmed S. Pituitary tumors. Endocrinol Metab Clin North Am. 2015 Mar; 44(1):1-9. PMID: 25732636; PMCID: PMC4351794.
    29. Melmed S, Popovic V, Bidlingmaier M, Mercado M, van der Lely AJ, Biermasz N, Bolanowski M, Coculescu M, Schopohl J, Racz K, Glaser B, Goth M, Greenman Y, Trainer P, Mezosi E, Shimon I, Giustina A, Korbonits M, Bronstein MD, Kleinberg D, Teichman S, Gliko-Kabir I, Mamluk R, Haviv A, Strasburger C. Safety and efficacy of oral octreotide in acromegaly: results of a multicenter phase III trial. J Clin Endocrinol Metab. 2015 Apr; 100(4):1699-708. PMID: 25664604.
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    30. Cuevas-Ramos D, Carmichael JD, Cooper O, Bonert VS, Gertych A, Mamelak AN, Melmed S. A structural and functional acromegaly classification. J Clin Endocrinol Metab. 2015 Jan; 100(1):122-31. PMID: 25250634; PMCID: PMC4283008.
    31. Liu X, Kano M, Araki T, Cooper O, Fukuoka H, Tone Y, Tone M, Melmed S. ErbB receptor-driven prolactinomas respond to targeted lapatinib treatment in female transgenic mice. Endocrinology. 2015 Jan; 156(1):71-9. PMID: 25375038; PMCID: PMC4272404.
    32. Katznelson L, Laws ER, Melmed S, Molitch ME, Murad MH, Utz A, Wass JA. Acromegaly: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2014 Nov; 99(11):3933-51. PMID: 25356808.
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    33. Melmed S, Kleinberg DL, Bonert V, Fleseriu M. Acromegaly: assessing the disorder and navigating therapeutic options for treatment. Endocr Pract. 2014 Oct; 20 Suppl 1:7-17; quiz 18-20. PMID: 25374336.
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    34. Gustafsson JA, Katzenellenbogen B, Jameson JL, Roth J, Melmed S, McDonnell D, Wartofsky L, Crowley WF, Griz LH, Becker C, Moore DD, Drucker D, Singh N, O'Malley B. Endocrine Society 2014 Laureate Awards. Horm Cancer. 2014 Oct; 5(5):339-55. PMID: 25091407.
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    35. Mo D, Hardin DS, Erfurth EM, Melmed S. Adult mortality or morbidity is not increased in childhood-onset growth hormone deficient patients who received pediatric GH treatment: an analysis of the Hypopituitary Control and Complications Study (HypoCCS). Pituitary. 2014 Oct; 17(5):477-85. PMID: 24122237; PMCID: PMC4159575.
    36. Keeley PW, Zhou C, Lu L, Williams RW, Melmed S, Reese BE. Pituitary tumor-transforming gene 1 regulates the patterning of retinal mosaics. Proc Natl Acad Sci U S A. 2014 Jun 24; 111(25):9295-300. PMID: 24927528; PMCID: PMC4078852.
    37. Melmed S, Vari SG. Challenges in life sciences and health systems in the 21st century. Croat Med J. 2014 Jun 01; 55(3):184-5. PMID: 24891276; PMCID: PMC4049212.
    38. Petersenn S, Farrall AJ, De Block C, Block C, Melmed S, Schopohl J, Caron P, Cuneo R, Kleinberg D, Colao A, Ruffin M, Hermosillo Reséndiz K, Hughes G, Hu K, Barkan A. Long-term efficacy and safety of subcutaneous pasireotide in acromegaly: results from an open-ended, multicenter, Phase II extension study. Pituitary. 2014 Apr; 17(2):132-40. PMID: 23529827.
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    39. Ben-Shlomo A, Mirocha J, Gwin SM, Khine AK, Liu NA, Sheinin RC, Melmed S. Clinical factors associated with biochemical adrenal-cortisol insufficiency in hospitalized patients. Am J Med. 2014 Aug; 127(8):754-762. PMID: 24632056; PMCID: PMC4127354.
    40. Giustina A, Chanson P, Kleinberg D, Bronstein MD, Clemmons DR, Klibanski A, van der Lely AJ, Strasburger CJ, Lamberts SW, Ho KK, Casanueva FF, Melmed S. Expert consensus document: A consensus on the medical treatment of acromegaly. Nat Rev Endocrinol. 2014 Apr; 10(4):243-8. PMID: 24566817.
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    41. Carmichael JD, Bonert VS, Nuño M, Ly D, Melmed S. Acromegaly clinical trial methodology impact on reported biochemical efficacy rates of somatostatin receptor ligand treatments: a meta-analysis. J Clin Endocrinol Metab. 2014 May; 99(5):1825-33. PMID: 24606084; PMCID: PMC4010703.
    42. Eigler T, Ben-Shlomo A, Zhou C, Khalafi R, Ren SG, Melmed S. Constitutive somatostatin receptor subtype-3 signaling suppresses growth hormone synthesis. Mol Endocrinol. 2014 Apr; 28(4):554-64. PMID: 24606125.
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    43. Donangelo I, Ren SG, Eigler T, Svendsen C, Melmed S. Sca1? murine pituitary adenoma cells show tumor-growth advantage. Endocr Relat Cancer. 2014 Apr; 21(2):203-16. PMID: 24481638; PMCID: PMC3978815.
    44. Mamelak AN, Carmichael J, Bonert VH, Cooper O, Melmed S. Single-surgeon fully endoscopic endonasal transsphenoidal surgery: outcomes in three-hundred consecutive cases. Pituitary. 2013 Sep; 16(3):393-401. PMID: 23011322.
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    45. Chesnokova V, Zhou C, Ben-Shlomo A, Zonis S, Tani Y, Ren SG, Melmed S. Growth hormone is a cellular senescence target in pituitary and nonpituitary cells. Proc Natl Acad Sci U S A. 2013 Aug 27; 110(35):E3331-9. PMID: 23940366; PMCID: PMC3761588.
    46. Ben-Shlomo A, Pichurin O, Khalafi R, Zhou C, Chesnokova V, Ren SG, Liu NA, Melmed S. Constitutive somatostatin receptor subtype 2 activity attenuates GH synthesis. Endocrinology. 2013 Jul; 154(7):2399-409. PMID: 23696564.
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    47. Melmed S. Idiopathic adult growth hormone deficiency. J Clin Endocrinol Metab. 2013 Jun; 98(6):2187-97. PMID: 23539718; PMCID: PMC3667267.
    48. Hartman ML, Xu R, Crowe BJ, Robison LL, Erfurth EM, Kleinberg DL, Zimmermann AG, Woodmansee WW, Cutler GB, Chipman JJ, Melmed S. Prospective safety surveillance of GH-deficient adults: comparison of GH-treated vs untreated patients. J Clin Endocrinol Metab. 2013 Mar; 98(3):980-8. PMID: 23345098; PMCID: PMC3677286.
    49. Chesnokova V, Zonis S, Wawrowsky K, Tani Y, Ben-Shlomo A, Ljubimov V, Mamelak A, Bannykh S, Melmed S. Clusterin and FOXL2 act concordantly to regulate pituitary gonadotroph adenoma growth. Mol Endocrinol. 2012 Dec; 26(12):2092-103. PMID: 23051594; PMCID: PMC3517712.
    50. Ghazi AA, Amirbaigloo A, Dezfooli AA, Saadat N, Ghazi S, Pourafkari M, Tirgari F, Dhall D, Bannykh S, Melmed S, Cooper O. Ectopic acromegaly due to growth hormone releasing hormone. Endocrine. 2013 Apr; 43(2):293-302. PMID: 22983831.
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    51. Somm E, Bonnet N, Martinez A, Marks PM, Cadd VA, Elliott M, Toulotte A, Ferrari SL, Rizzoli R, Hüppi PS, Harper E, Melmed S, Jones R, Aubert ML. A botulinum toxin-derived targeted secretion inhibitor downregulates the GH/IGF1 axis. J Clin Invest. 2012 Sep; 122(9):3295-306. PMID: 22850878; PMCID: PMC3428092.
    52. Toledano Y, Zonis S, Ren SG, Wawrowsky K, Chesnokova V, Melmed S. Estradiol partially recapitulates murine pituitary cell cycle response to pregnancy. Endocrinology. 2012 Oct; 153(10):5011-22. PMID: 22851678.
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    53. Thakker RV, Newey PJ, Walls GV, Bilezikian J, Dralle H, Ebeling PR, Melmed S, Sakurai A, Tonelli F, Brandi ML. Clinical practice guidelines for multiple endocrine neoplasia type 1 (MEN1). J Clin Endocrinol Metab. 2012 Sep; 97(9):2990-3011. PMID: 22723327.
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    54. Gruszka A, Culler MD, Melmed S. Somatostatin analogs and chimeric somatostatin-dopamine molecules differentially regulate human growth hormone and prolactin gene expression and secretion in vitro. Mol Cell Endocrinol. 2012 Oct 15; 362(1-2):104-9. PMID: 22705877.
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    55. Tong Y, Zheng Y, Zhou J, Oyesiku NM, Koeffler HP, Melmed S. Genomic characterization of human and rat prolactinomas. Endocrinology. 2012 Aug; 153(8):3679-91. PMID: 22635680; PMCID: PMC3404356.
    56. Cooper O, Melmed S. Subclinical hyperfunctioning pituitary adenomas: the silent tumors. Best Pract Res Clin Endocrinol Metab. 2012 Aug; 26(4):447-60. PMID: 22863387; PMCID: PMC3412996.
    57. Giustina A, Mazziotti G, Torri V, Spinello M, Floriani I, Melmed S. Meta-analysis on the effects of octreotide on tumor mass in acromegaly. PLoS One. 2012; 7(5):e36411. PMID: 22574156; PMCID: PMC3344864.
    58. Fukuoka H, Cooper O, Ben-Shlomo A, Mamelak A, Ren SG, Bruyette D, Melmed S. EGFR as a therapeutic target for human, canine, and mouse ACTH-secreting pituitary adenomas. J Clin Invest. 2011 Dec; 121(12):4712-21. PMID: 22105169; PMCID: PMC3226010.
    59. Cooper O, Vlotides G, Fukuoka H, Greene MI, Melmed S. Expression and function of ErbB receptors and ligands in the pituitary. Endocr Relat Cancer. 2011 Oct; 18(6):R197-211. PMID: 21917845; PMCID: PMC3758362.
    60. Tong Y, Zhou J, Mizutani J, Fukuoka H, Ren SG, Gutierrez-Hartmann A, Koeffler HP, Melmed S. CEBPD suppresses prolactin expression and prolactinoma cell proliferation. Mol Endocrinol. 2011 Nov; 25(11):1880-91. PMID: 21980073; PMCID: PMC3198962.
    61. Tong Y, Zhao W, Zhou C, Wawrowsky K, Melmed S. PTTG1 attenuates drug-induced cellular senescence. PLoS One. 2011; 6(8):e23754. PMID: 21858218; PMCID: PMC3157437.
    62. Liu NA, Jiang H, Ben-Shlomo A, Wawrowsky K, Fan XM, Lin S, Melmed S. Targeting zebrafish and murine pituitary corticotroph tumors with a cyclin-dependent kinase (CDK) inhibitor. Proc Natl Acad Sci U S A. 2011 May 17; 108(20):8414-9. PMID: 21536883; PMCID: PMC3100964.
    63. Famini P, Maya MM, Melmed S. Pituitary magnetic resonance imaging for sellar and parasellar masses: ten-year experience in 2598 patients. J Clin Endocrinol Metab. 2011 Jun; 96(6):1633-41. PMID: 21470998; PMCID: PMC3100749.
    64. Chesnokova V, Zonis S, Zhou C, Ben-Shlomo A, Wawrowsky K, Toledano Y, Tong Y, Kovacs K, Scheithauer B, Melmed S. Lineage-specific restraint of pituitary gonadotroph cell adenoma growth. PLoS One. 2011 Mar 25; 6(3):e17924. PMID: 21464964; PMCID: PMC3064664.
    65. Melmed S. Pathogenesis of pituitary tumors. Nat Rev Endocrinol. 2011 May; 7(5):257-66. PMID: 21423242.
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    66. Melmed S, Casanueva FF, Hoffman AR, Kleinberg DL, Montori VM, Schlechte JA, Wass JA. Diagnosis and treatment of hyperprolactinemia: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011 Feb; 96(2):273-88. PMID: 21296991.
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    67. Hoffman AR, Melmed S, Schlechte J. Patient guide to hyperprolactinemia diagnosis and treatment. J Clin Endocrinol Metab. 2011 Feb; 96(2):35A-6A. PMID: 21296988.
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    68. Ríos Y, Melmed S, Lin S, Liu NA. Zebrafish usp39 mutation leads to rb1 mRNA splicing defect and pituitary lineage expansion. PLoS Genet. 2011 Jan 13; 7(1):e1001271. PMID: 21249182; PMCID: PMC3020934.
    69. Fukuoka H, Cooper O, Mizutani J, Tong Y, Ren SG, Bannykh S, Melmed S. HER2/ErbB2 receptor signaling in rat and human prolactinoma cells: strategy for targeted prolactinoma therapy. Mol Endocrinol. 2011 Jan; 25(1):92-103. PMID: 21106881; PMCID: PMC3089034.
    70. Klibanski A, Melmed S, Clemmons DR, Colao A, Cunningham RS, Molitch ME, Vinik AI, Adelman DT, Liebert KJ. The endocrine tumor summit 2008: appraising therapeutic approaches for acromegaly and carcinoid syndrome. Pituitary. 2010 Sep; 13(3):266-86. PMID: 20012914; PMCID: PMC2913001.
    71. Chesnokova V, Zonis S, Ben-Shlomo A, Wawrowsky K, Melmed S. Molecular mechanisms of pituitary adenoma senescence. Front Horm Res. 2010; 38:7-14. PMID: 20616490.
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    72. Cooper O, Ben-Shlomo A, Bonert V, Bannykh S, Mirocha J, Melmed S. Silent corticogonadotroph adenomas: clinical and cellular characteristics and long-term outcomes. Horm Cancer. 2010 Apr; 1(2):80-92. PMID: 20717480.
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    73. Chesnokova V, Melmed S. Pituitary senescence: the evolving role of Pttg. Mol Cell Endocrinol. 2010 Sep 15; 326(1-2):55-9. PMID: 20153804; PMCID: PMC2906651.
    74. Ben-Shlomo A, Melmed S. Pituitary somatostatin receptor signaling. Trends Endocrinol Metab. 2010 Mar; 21(3):123-33. PMID: 20149677; PMCID: PMC2834886.
    75. Ben-Shlomo A, Wawrowsky K, Melmed S. Constitutive activity of somatostatin receptor subtypes. Methods Enzymol. 2010; 484:149-64. PMID: 21036231.
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    76. Yu R, Melmed S. Pathogenesis of pituitary tumors. Prog Brain Res. 2010; 182:207-27. PMID: 20541667.
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    77. Webb SM, Mo D, Lamberts SW, Melmed S, Cavagnini F, Pecori Giraldi F, Strasburger CJ, Zimmermann AG, Woodmansee WW. Metabolic, cardiovascular, and cerebrovascular outcomes in growth hormone-deficient subjects with previous cushing's disease or non-functioning pituitary adenoma. J Clin Endocrinol Metab. 2010 Feb; 95(2):630-8. PMID: 20022992.
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    78. Ben-Shlomo A, Schmid H, Wawrowsky K, Pichurin O, Hubina E, Chesnokova V, Liu NA, Culler M, Melmed S. Differential Ligand-Mediated Pituitary Somatostatin Receptor Subtype Signaling: Implications for Corticotroph Tumor Therapy. Endocr Rev. 2009 Dec 01; 30(7):933. PMID: 28199544.
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    79. Melmed S. Acromegaly pathogenesis and treatment. J Clin Invest. 2009 Nov; 119(11):3189-202. PMID: 19884662; PMCID: PMC2769196.
    80. Zhou C, Wawrowsky K, Bannykh S, Gutman S, Melmed S. E2F1 induces pituitary tumor transforming gene (PTTG1) expression in human pituitary tumors. Mol Endocrinol. 2009 Dec; 23(12):2000-12. PMID: 19837943.
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    81. Ben-Shlomo A, Schmid H, Wawrowsky K, Pichurin O, Hubina E, Chesnokova V, Liu NA, Culler M, Melmed S. Differential ligand-mediated pituitary somatostatin receptor subtype signaling: implications for corticotroph tumor therapy. J Clin Endocrinol Metab. 2009 Nov; 94(11):4342-50. PMID: 19820006.
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    82. Melmed S, Cook D, Schopohl J, Goth MI, Lam KS, Marek J. Rapid and sustained reduction of serum growth hormone and insulin-like growth factor-1 in patients with acromegaly receiving lanreotide Autogel therapy: a randomized, placebo-controlled, multicenter study with a 52 week open extension. Pituitary. 2010; 13(1):18-28. PMID: 19639415; PMCID: PMC2807598.
    83. Chesnokova V, Melmed S. Pituitary tumour-transforming gene (PTTG) and pituitary senescence. Horm Res. 2009 Apr; 71 Suppl 2:82-7. PMID: 19407503.
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    84. Vlotides G, Cooper O, Chen YH, Ren SG, Greenman Y, Melmed S. Heregulin regulates prolactinoma gene expression. Cancer Res. 2009 May 15; 69(10):4209-16. PMID: 19401448; PMCID: PMC2688701.
    85. Vlotides G, Chen YH, Eigler T, Ren SG, Melmed S. Fibroblast growth factor-2 autofeedback regulation in pituitary folliculostellate TtT/GF cells. Endocrinology. 2009 Jul; 150(7):3252-8. PMID: 19359387; PMCID: PMC2703553.
    86. Arzt E, Chesnokova V, Stalla GK, Melmed S. Pituitary adenoma growth: a model for cellular senescence and cytokine action. Cell Cycle. 2009 Mar 01; 8(5):677-8. PMID: 19223763; PMCID: PMC2710531.
    87. Ben-Shlomo A, Zhou C, Pichurin O, Chesnokova V, Liu NA, Culler MD, Melmed S. Constitutive somatostatin receptor activity determines tonic pituitary cell response. Mol Endocrinol. 2009 Mar; 23(3):337-48. PMID: 19131507.
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    88. Carmichael JD, Bonert VS, Mirocha JM, Melmed S. The utility of oral glucose tolerance testing for diagnosis and assessment of treatment outcomes in 166 patients with acromegaly. J Clin Endocrinol Metab. 2009 Feb; 94(2):523-7. PMID: 19033371.
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    89. Webb SM, Strasburger CJ, Mo D, Hartman ML, Melmed S, Jung H, Blum WF, Attanasio AF. Changing patterns of the adult growth hormone deficiency diagnosis documented in a decade-long global surveillance database. J Clin Endocrinol Metab. 2009 Feb; 94(2):392-9. PMID: 19001512.
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    90. Chesnokova V, Zonis S, Kovacs K, Ben-Shlomo A, Wawrowsky K, Bannykh S, Melmed S. p21(Cip1) restrains pituitary tumor growth. Proc Natl Acad Sci U S A. 2008 Nov 11; 105(45):17498-503. PMID: 18981426.
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    91. Vlotides G, Siegel E, Donangelo I, Gutman S, Ren SG, Melmed S. Rat prolactinoma cell growth regulation by epidermal growth factor receptor ligands. Cancer Res. 2008 Aug 01; 68(15):6377-86. PMID: 18676863; PMCID: PMC2497431.
    92. Bonert VS, Kennedy L, Petersenn S, Barkan A, Carmichael J, Melmed S. Lipodystrophy in patients with acromegaly receiving pegvisomant. J Clin Endocrinol Metab. 2008 Sep; 93(9):3515-8. PMID: 18611977.
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    93. Zhou C, Tong Y, Wawrowsky K, Bannykh S, Donangelo I, Melmed S. Oct-1 induces pituitary tumor transforming gene expression in endocrine tumors. Endocr Relat Cancer. 2008 Sep; 15(3):817-31. PMID: 18550719; PMCID: PMC3123374.
    94. Murray RD, Melmed S. A critical analysis of clinically available somatostatin analog formulations for therapy of acromegaly. J Clin Endocrinol Metab. 2008 Aug; 93(8):2957-68. PMID: 18477663.
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    95. Liu NA, Ren M, Song J, Ríos Y, Wawrowsky K, Ben-Shlomo A, Lin S, Melmed S. In vivo time-lapse imaging delineates the zebrafish pituitary proopiomelanocortin lineage boundary regulated by FGF3 signal. Dev Biol. 2008 Jul 15; 319(2):192-200. PMID: 18514643; PMCID: PMC2583244.
    96. Ben-Shlomo A, Melmed S. Acromegaly. Endocrinol Metab Clin North Am. 2008 Mar; 37(1):101-22, viii. PMID: 18226732; PMCID: PMC2697616.
    97. Cooper O, Geller JL, Melmed S. Ovarian hyperstimulation syndrome caused by an FSH-secreting pituitary adenoma. Nat Clin Pract Endocrinol Metab. 2008 Apr; 4(4):234-8. PMID: 18268519; PMCID: PMC2777809.
    98. Melmed GY, Devlin SM, Vlotides G, Dhall D, Ross S, Yu R, Melmed S. Anti-aging therapy with human growth hormone associated with metastatic colon cancer in a patient with Crohn's colitis. Clin Gastroenterol Hepatol. 2008 Mar; 6(3):360-3. PMID: 18255351; PMCID: PMC2696478.
    99. Melmed S. Update in pituitary disease. J Clin Endocrinol Metab. 2008 Feb; 93(2):331-8. PMID: 18258780.
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    100. Ben-Shlomo A, Melmed S. Pasireotide--a somatostatin analog for the potential treatment of acromegaly, neuroendocrine tumors and Cushing's disease. IDrugs. 2007 Dec; 10(12):885-95. PMID: 18041687.
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    101. Ben-Shlomo A, Melmed S. Somatostatin agonists for treatment of acromegaly. Mol Cell Endocrinol. 2008 May 14; 286(1-2):192-8. PMID: 18191325; PMCID: PMC2697610.
    102. Chesnokova V, Zonis S, Rubinek T, Yu R, Ben-Shlomo A, Kovacs K, Wawrowsky K, Melmed S. Senescence mediates pituitary hypoplasia and restrains pituitary tumor growth. Cancer Res. 2007 Nov 01; 67(21):10564-72. PMID: 17975001; PMCID: PMC2770267.
    103. Gruszka A, Ren SG, Dong J, Culler MD, Melmed S. Regulation of growth hormone and prolactin gene expression and secretion by chimeric somatostatin-dopamine molecules. Endocrinology. 2007 Dec; 148(12):6107-14. PMID: 17656461.
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    104. Rubinek T, Chesnokova V, Wolf I, Wawrowsky K, Vlotides G, Melmed S. Discordant proliferation and differentiation in pituitary tumor-transforming gene-null bone marrow stem cells. Am J Physiol Cell Physiol. 2007 Sep; 293(3):C1082-92. PMID: 17626243.
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    105. Ben-Shlomo A, Pichurin O, Barshop NJ, Wawrowsky KA, Taylor J, Culler MD, Chesnokova V, Liu NA, Melmed S. Selective regulation of somatostatin receptor subtype signaling: evidence for constitutive receptor activation. Mol Endocrinol. 2007 Oct; 21(10):2565-78. PMID: 17609435.
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    106. Melmed S. Aryl hydrocarbon receptor interacting protein and pituitary tumorigenesis: another interesting protein. J Clin Endocrinol Metab. 2007 May; 92(5):1617-9. PMID: 17483376.
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    107. Vlotides G, Eigler T, Melmed S. Pituitary tumor-transforming gene: physiology and implications for tumorigenesis. Endocr Rev. 2007 Apr; 28(2):165-86. PMID: 17325339.
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    108. Melmed S. Medical progress: Acromegaly. N Engl J Med. 2006 Dec 14; 355(24):2558-73. PMID: 17167139.
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    109. Yu R, Bonert V, Saporta I, Raffel LJ, Melmed S. Aryl hydrocarbon receptor interacting protein variants in sporadic pituitary adenomas. J Clin Endocrinol Metab. 2006 Dec; 91(12):5126-9. PMID: 17018653.
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    110. Yu R, Cruz-Soto M, Li Calzi S, Hui H, Melmed S. Murine pituitary tumor-transforming gene functions as a securin protein in insulin-secreting cells. J Endocrinol. 2006 Oct; 191(1):45-53. PMID: 17065388.
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    111. Ben-Shlomo A, Melmed S. Skin manifestations in acromegaly. Clin Dermatol. 2006 Jul-Aug; 24(4):256-9. PMID: 16828406.
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    112. Bonert VS, Melmed S. Acromegaly with moderate hyperprolactinemia caused by an intrasellar macroadenoma. Nat Clin Pract Endocrinol Metab. 2006 Jul; 2(7):408-12; quiz following 412. PMID: 16932323.
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    113. Donangelo I, Gutman S, Horvath E, Kovacs K, Wawrowsky K, Mount M, Melmed S. Pituitary tumor transforming gene overexpression facilitates pituitary tumor development. Endocrinology. 2006 Oct; 147(10):4781-91. PMID: 16809444.
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    114. Ren SG, Melmed S. Pyridoxal phosphate inhibits pituitary cell proliferation and hormone secretion. Endocrinology. 2006 Aug; 147(8):3936-42. PMID: 16690808.
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    115. Lum PY, Chen Y, Zhu J, Lamb J, Melmed S, Wang S, Drake TA, Lusis AJ, Schadt EE. Elucidating the murine brain transcriptional network in a segregating mouse population to identify core functional modules for obesity and diabetes. J Neurochem. 2006 Apr; 97 Suppl 1:50-62. PMID: 16635250.
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    116. Melmed S. Supplemental growth hormone in healthy adults: the endocrinologist's responsibility. Nat Clin Pract Endocrinol Metab. 2006 Mar; 2(3):119. PMID: 16932266.
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    117. Akita S, Akino K, Ren SG, Melmed S, Imaizumi T, Hirano A. Elevated circulating leukemia inhibitory factor in patients with extensive burns. J Burn Care Res. 2006 Mar-Apr; 27(2):221-5. PMID: 16566572.
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    118. Yu R, Bonert V, Cruz-Soto M, Melmed S. Cyclin-dependent kinase inhibitor gene polymorphisms in pituitary gigantism. Endocrine. 2006 Feb; 29(1):119-20. PMID: 16622299.
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    119. Bronstein MD, Melmed S. [Pituitary tumorigenesis]. Arq Bras Endocrinol Metabol. 2005 Oct; 49(5):615-25. PMID: 16444345.
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    120. Gillingwater TH, Wishart TM, Chen PE, Haley JE, Robertson K, MacDonald SH, Middleton S, Wawrowski K, Shipston MJ, Melmed S, Wyllie DJ, Skehel PA, Coleman MP, Ribchester RR. The neuroprotective WldS gene regulates expression of PTTG1 and erythroid differentiation regulator 1-like gene in mice and human cells. Hum Mol Genet. 2006 Feb 15; 15(4):625-35. PMID: 16403805.
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    121. Donangelo I, Melmed S. Implication of pituitary tropic status on tumor development. Front Horm Res. 2006; 35:1-8. PMID: 16809918.
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    122. Liu NA, Liu Q, Wawrowsky K, Yang Z, Lin S, Melmed S. Prolactin receptor signaling mediates the osmotic response of embryonic zebrafish lactotrophs. Mol Endocrinol. 2006 Apr; 20(4):871-80. PMID: 16339273.
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    123. Melmed S. 2004 World Health Organization classification of pituitary tumors: what is new? Acta Neuropathol. 2006 Jan; 111(1):78-9. PMID: 16328519.
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    124. Donangelo I, Melmed S. Treatment of acromegaly: future. Endocrine. 2005 Oct; 28(1):123-8. PMID: 16311419.
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    125. Akino K, Akita S, Mizuguchi T, Takumi I, Yu R, Wang XY, Rozga J, Demetriou AA, Melmed S, Ohtsuru A, Yamashita S. A novel molecular marker of pituitary tumor transforming gene involves in a rat liver regeneration. J Surg Res. 2005 Nov; 129(1):142-6. PMID: 15936773.
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    126. Chesnokova V, Kovacs K, Castro AV, Zonis S, Melmed S. Pituitary hypoplasia in Pttg-/- mice is protective for Rb+/- pituitary tumorigenesis. Mol Endocrinol. 2005 Sep; 19(9):2371-9. PMID: 15919720; PMCID: PMC1201444.
    127. Ben-Shlomo A, Wawrowsky KA, Proekt I, Wolkenfeld NM, Ren SG, Taylor J, Culler MD, Melmed S. Somatostatin receptor type 5 modulates somatostatin receptor type 2 regulation of adrenocorticotropin secretion. J Biol Chem. 2005 Jun 24; 280(25):24011-21. PMID: 15857828.
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    128. Melmed S, Sternberg R, Cook D, Klibanski A, Chanson P, Bonert V, Vance ML, Rhew D, Kleinberg D, Barkan A. A critical analysis of pituitary tumor shrinkage during primary medical therapy in acromegaly. J Clin Endocrinol Metab. 2005 Jul; 90(7):4405-10. PMID: 15827109.
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    129. Abbud RA, Takumi I, Barker EM, Ren SG, Chen DY, Wawrowsky K, Melmed S. Early multipotential pituitary focal hyperplasia in the alpha-subunit of glycoprotein hormone-driven pituitary tumor-transforming gene transgenic mice. Mol Endocrinol. 2005 May; 19(5):1383-91. PMID: 15677710.
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    130. Murray RD, Kim K, Ren SG, Chelly M, Umehara Y, Melmed S. Central and peripheral actions of somatostatin on the growth hormone-IGF-I axis. J Clin Invest. 2004 Aug; 114(3):349-56. PMID: 15286801.
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    131. Bonert VS, Elashoff JD, Barnett P, Melmed S. Body mass index determines evoked growth hormone (GH) responsiveness in normal healthy male subjects: diagnostic caveat for adult GH deficiency. J Clin Endocrinol Metab. 2004 Jul; 89(7):3397-401. PMID: 15240621.
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    132. Murray RD, Kim K, Ren SG, Lewis I, Weckbecker G, Bruns C, Melmed S. The novel somatostatin ligand (SOM230) regulates human and rat anterior pituitary hormone secretion. J Clin Endocrinol Metab. 2004 Jun; 89(6):3027-32. PMID: 15181094.
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    133. Heaney AP, Melmed S. Molecular targets in pituitary tumours. Nat Rev Cancer. 2004 Apr; 4(4):285-95. PMID: 15057288.
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    134. Yu R, Melmed S. Pituitary tumor transforming gene: an update. Front Horm Res. 2004; 32:175-85. PMID: 15281346.
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    135. Melmed S. Mechanisms for pituitary tumorigenesis: the plastic pituitary. J Clin Invest. 2003 Dec; 112(11):1603-18. PMID: 14660734; PMCID: PMC281651.
    136. Ren SG, Kim S, Taylor J, Dong J, Moreau JP, Culler MD, Melmed S. Suppression of rat and human growth hormone and prolactin secretion by a novel somatostatin/dopaminergic chimeric ligand. J Clin Endocrinol Metab. 2003 Nov; 88(11):5414-21. PMID: 14602782.
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    137. Abbud RA, Kelleher R, Melmed S. Cell-specific pituitary gene expression profiles after treatment with leukemia inhibitory factor reveal novel modulators for proopiomelanocortin expression. Endocrinology. 2004 Feb; 145(2):867-80. PMID: 14576184.
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    138. Clemmons DR, Chihara K, Freda PU, Ho KK, Klibanski A, Melmed S, Shalet SM, Strasburger CJ, Trainer PJ, Thorner MO. Optimizing control of acromegaly: integrating a growth hormone receptor antagonist into the treatment algorithm. J Clin Endocrinol Metab. 2003 Oct; 88(10):4759-67. PMID: 14557452.
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    139. Turner HE, Harris AL, Melmed S, Wass JA. Angiogenesis in endocrine tumors. Endocr Rev. 2003 Oct; 24(5):600-32. PMID: 14570746.
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    140. Ren SG, Taylor J, Dong J, Yu R, Culler MD, Melmed S. Functional association of somatostatin receptor subtypes 2 and 5 in inhibiting human growth hormone secretion. J Clin Endocrinol Metab. 2003 Sep; 88(9):4239-45. PMID: 12970293.
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    141. Rubinek T, Yu R, Hadani M, Barkai G, Nass D, Melmed S, Shimon I. The cell adhesion molecules N-cadherin and neural cell adhesion molecule regulate human growth hormone: a novel mechanism for regulating pituitary hormone secretion. J Clin Endocrinol Metab. 2003 Aug; 88(8):3724-30. PMID: 12915661.
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    142. Yu R, Lu W, Chen J, McCabe CJ, Melmed S. Overexpressed pituitary tumor-transforming gene causes aneuploidy in live human cells. Endocrinology. 2003 Nov; 144(11):4991-8. PMID: 12960092.
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    143. Heaney AP, Fernando M, Melmed S. PPAR-gamma receptor ligands: novel therapy for pituitary adenomas. J Clin Invest. 2003 May; 111(9):1381-8. PMID: 12727930; PMCID: PMC154441.
    144. Giustina A, Melmed S. Acromegaly consensus: the next steps. J Clin Endocrinol Metab. 2003 Apr; 88(4):1913-4. PMID: 12679495.
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    145. Wang Z, Moro E, Kovacs K, Yu R, Melmed S. Pituitary tumor transforming gene-null male mice exhibit impaired pancreatic beta cell proliferation and diabetes. Proc Natl Acad Sci U S A. 2003 Mar 18; 100(6):3428-32. PMID: 12626748; PMCID: PMC152309.
    146. Ben-Shlomo A, Melmed S. Clinical review 154: The role of pharmacotherapy in perioperative management of patients with acromegaly. J Clin Endocrinol Metab. 2003 Mar; 88(3):963-8. PMID: 12629068.
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    147. Liu NA, Huang H, Yang Z, Herzog W, Hammerschmidt M, Lin S, Melmed S. Pituitary corticotroph ontogeny and regulation in transgenic zebrafish. Mol Endocrinol. 2003 May; 17(5):959-66. PMID: 12576489.
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    148. Ben-Shlomo A, Miklovsky I, Ren SG, Yong WH, Heaney AP, Culler MD, Melmed S. Leukemia inhibitory factor regulates prolactin secretion in prolactinoma and lactotroph cells. J Clin Endocrinol Metab. 2003 Feb; 88(2):858-63. PMID: 12574225.
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    149. Horwitz GA, Miklovsky I, Heaney AP, Ren SG, Melmed S. Human pituitary tumor-transforming gene (PTTG1) motif suppresses prolactin expression. Mol Endocrinol. 2003 Apr; 17(4):600-9. PMID: 12554778.
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    150. Stoika R, Melmed S. Expression and function of pituitary tumour transforming gene for T-lymphocyte activation. Br J Haematol. 2002 Dec; 119(4):1070-4. PMID: 12472590.
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    151. Heaney AP, Fernando M, Yong WH, Melmed S. Functional PPAR-gamma receptor is a novel therapeutic target for ACTH-secreting pituitary adenomas. Nat Med. 2002 Nov; 8(11):1281-7. PMID: 12379847.
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    152. Chesnokova V, Melmed S. Minireview: Neuro-immuno-endocrine modulation of the hypothalamic-pituitary-adrenal (HPA) axis by gp130 signaling molecules. Endocrinology. 2002 May; 143(5):1571-4. PMID: 11956136.
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    153. Chesnokova V, Kariagina A, Melmed S. Opposing effects of pituitary leukemia inhibitory factor and SOCS-3 on the ACTH axis response to inflammation. Am J Physiol Endocrinol Metab. 2002 May; 282(5):E1110-8. PMID: 11934677.
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    154. Heaney AP, Fernando M, Melmed S. Functional role of estrogen in pituitary tumor pathogenesis. J Clin Invest. 2002 Jan; 109(2):277-83. PMID: 11805140; PMCID: PMC150842.
    155. Melmed S, Vance ML, Barkan AL, Bengtsson BA, Kleinberg D, Klibanski A, Trainer PJ. Current status and future opportunities for controlling acromegaly. Pituitary. 2002; 5(3):185-96. PMID: 12812311.
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    156. Stefaneanu L, Kovacs K, Thapar K, Horvath E, Melmed S, Greenman Y. Octreotide Effect on Growth Hormone and Somatostatin Subtype 2 Receptor mRNAs of the Human Pituitary Somatotroph Adenomas. Endocr Pathol. 2000; 11(1):41-48. PMID: 12114656.
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