Beaven Simon

Title(s)Member, CTSI
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    Other Positions
    Title(s)Assistant Professor, Digestive Diseases/Gastroenterology

    Title(s)Member, Hepatology

    Title(s)Member, Molecular Cellular & Integrative Physiology GPB Home Area

    Title(s)Member, Pfleger Liver Institute

    Title(s)Member, themes

    Collapse Research 
    Collapse Research Activities and Funding
    The Role of Liver X Receptors (LXRs) in the Pathogenesis of Hepatic Fibrosis
    NIH/NIDDK K08DK088998Jul 1, 2010 - Jun 30, 2015
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Yin F, Gupta R, Vergnes L, Driscoll WS, Ricks J, Ramanathan G, Stewart JA, Shih DM, Faull KF, Beaven SW, Lusis AJ, Reue K, Rosenfeld ME, Araujo JA. Diesel Exhaust Induces Mitochondrial Dysfunction, Hyperlipidemia and Liver Steatosis. Arterioscler Thromb Vasc Biol. 2019 Jul 25; ATVBAHA119312736. PMID: 31340670.
      View in: PubMed
    2. Hui ST, Kurt Z, Tuominen I, Norheim F, C Davis R, Pan C, Dirks DL, Magyar CE, French SW, Chella Krishnan K, Sabir S, Campos-Pérez F, Méndez-Sánchez N, Macías-Kauffer L, León-Mimila P, Canizales-Quinteros S, Yang X, Beaven SW, Huertas-Vazquez A, Lusis AJ. The Genetic Architecture of Diet-Induced Hepatic Fibrosis in Mice. Hepatology. 2018 12; 68(6):2182-2196. PMID: 29907965.
      View in: PubMed
    3. Ribas V, Drew BG, Zhou Z, Phun J, Kalajian NY, Soleymani T, Daraei P, Widjaja K, Wanagat J, de Aguiar Vallim TQ, Fluitt AH, Bensinger S, Le T, Radu C, Whitelegge JP, Beaven SW, Tontonoz P, Lusis AJ, Parks BW, Vergnes L, Reue K, Singh H, Bopassa JC, Toro L, Stefani E, Watt MJ, Schenk S, Akerstrom T, Kelly M, Pedersen BK, Hewitt SC, Korach KS, Hevener AL. Skeletal muscle action of estrogen receptor a is critical for the maintenance of mitochondrial function and metabolic homeostasis in females. Sci Transl Med. 2016 Apr 13; 8(334):334ra54. PMID: 27075628.
      View in: PubMed
    4. Lu NT, Crespi CM, Liu NM, Vu JQ, Ahmadieh Y, Wu S, Lin S, McClune A, Durazo F, Saab S, Han S, Neiman DC, Beaven S, French SW. A Phase I Dose Escalation Study Demonstrates Quercetin Safety and Explores Potential for Bioflavonoid Antivirals in Patients with Chronic Hepatitis C. Phytother Res. 2016 Jan; 30(1):160-8. PMID: 26621580.
      View in: PubMed
    5. Tuominen I, Beaven SW. Intestinal farnesoid X receptor puts a fresh coat of wax on fatty liver. Hepatology. 2015 Aug; 62(2):646-8. PMID: 25998695; PMCID: PMC4523235.
    6. O'Mahony F, Wroblewski K, O'Byrne SM, Jiang H, Clerkin K, Benhammou J, Blaner WS, Beaven SW. Liver X receptors balance lipid stores in hepatic stellate cells through Rab18, a retinoid responsive lipid droplet protein. Hepatology. 2015 Aug; 62(2):615-26. PMID: 25482505; PMCID: PMC4458237.
    7. Beaven SW. La mort de la lipogenèse: RNF20 lashes ubiquitin to SREBP-1c. Hepatology. 2014 Sep; 60(3):776-8. PMID: 24604429; PMCID: PMC4607314.
    8. Clark PM, Flores G, Evdokimov NM, McCracken MN, Chai T, Nair-Gill E, O'Mahony F, Beaven SW, Faull KF, Phelps ME, Jung ME, Witte ON. Positron emission tomography probe demonstrates a striking concentration of ribose salvage in the liver. Proc Natl Acad Sci U S A. 2014 Jul 15; 111(28):E2866-74. PMID: 24982199; PMCID: PMC4104878.
    9. Beaven SW, Matveyenko A, Wroblewski K, Chao L, Wilpitz D, Hsu TW, Lentz J, Drew B, Hevener AL, Tontonoz P. Reciprocal regulation of hepatic and adipose lipogenesis by liver X receptors in obesity and insulin resistance. Cell Metab. 2013 Jul 02; 18(1):106-17. PMID: 23823481; PMCID: PMC4089509.
    10. Ghazalpour A, Rau CD, Farber CR, Bennett BJ, Orozco LD, van Nas A, Pan C, Allayee H, Beaven SW, Civelek M, Davis RC, Drake TA, Friedman RA, Furlotte N, Hui ST, Jentsch JD, Kostem E, Kang HM, Kang EY, Joo JW, Korshunov VA, Laughlin RE, Martin LJ, Ohmen JD, Parks BW, Pellegrini M, Reue K, Smith DJ, Tetradis S, Wang J, Wang Y, Weiss JN, Kirchgessner T, Gargalovic PS, Eskin E, Lusis AJ, LeBoeuf RC. Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits. Mamm Genome. 2012 Oct; 23(9-10):680-92. PMID: 22892838; PMCID: PMC3586763.
    11. Chen X, McClusky R, Chen J, Beaven SW, Tontonoz P, Arnold AP, Reue K. The number of x chromosomes causes sex differences in adiposity in mice. PLoS Genet. 2012; 8(5):e1002709. PMID: 22589744; PMCID: PMC3349739.
    12. Hong C, Kidani Y, A-Gonzalez N, Phung T, Ito A, Rong X, Ericson K, Mikkola H, Beaven SW, Miller LS, Shao WH, Cohen PL, Castrillo A, Tontonoz P, Bensinger SJ. Coordinate regulation of neutrophil homeostasis by liver X receptors in mice. J Clin Invest. 2012 Jan; 122(1):337-47. PMID: 22156197; PMCID: PMC3248291.
    13. Beaven SW, Wroblewski K, Wang J, Hong C, Bensinger S, Tsukamoto H, Tontonoz P. Liver X receptor signaling is a determinant of stellate cell activation and susceptibility to fibrotic liver disease. Gastroenterology. 2011 Mar; 140(3):1052-62. PMID: 21134374.
      View in: PubMed
    14. Ribas V, Nguyen MT, Henstridge DC, Nguyen AK, Beaven SW, Watt MJ, Hevener AL. Impaired oxidative metabolism and inflammation are associated with insulin resistance in ERalpha-deficient mice. Am J Physiol Endocrinol Metab. 2010 Feb; 298(2):E304-19. PMID: 19920214; PMCID: PMC2822483.
    15. Dean JT, Tran L, Beaven S, Tontonoz P, Reue K, Dipple KM, Liao JC. Resistance to diet-induced obesity in mice with synthetic glyoxylate shunt. Cell Metab. 2009 Jun; 9(6):525-36. PMID: 19490907; PMCID: PMC4277884.
    16. Bansal MB, Beaven SW, Rockey DC. Scott L. Friedman, 59th President, AASLD. Hepatology. 2008 Nov; 48(5):1357-8. PMID: 18972438.
      View in: PubMed
    17. Banck MS, Beaven SW, Narla G, Walsh MJ, Friedman SL, Beutler AS. KLF6 degradation after apoptotic DNA damage. FEBS Lett. 2006 Dec 22; 580(30):6981-6. PMID: 17113081.
      View in: PubMed
    18. Chen M, Bradley MN, Beaven SW, Tontonoz P. Phosphorylation of the liver X receptors. FEBS Lett. 2006 Sep 04; 580(20):4835-41. PMID: 16904112.
      View in: PubMed
    19. Beaven SW, Tontonoz P. Nuclear receptors in lipid metabolism: targeting the heart of dyslipidemia. Annu Rev Med. 2006; 57:313-29. PMID: 16409152.
      View in: PubMed
    20. Chen M, Beaven S, Tontonoz P. Identification and characterization of two alternatively spliced transcript variants of human liver X receptor alpha. J Lipid Res. 2005 Dec; 46(12):2570-9. PMID: 16170053.
      View in: PubMed
    21. Beaven SW, Martín MG. Tales from the crypt: beta-catenin in the development of juvenile polyps: commentary on the article by Iwamoto et al. on page 4. Pediatr Res. 2005 Jan; 57(1):1-3. PMID: 15557110.
      View in: PubMed
    22. Beaven SW, Abreu MT. Biomarkers in inflammatory bowel disease. Curr Opin Gastroenterol. 2004 Jul; 20(4):318-27. PMID: 15703659.
      View in: PubMed