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Srikanth Sonal

Title(s)Adjunct Assistant Professor, Physiology
Phone(310) 794-2127
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    Distinct functions of Orai1 and Orai2 in naive and effector helper T cells
    NIH/NIAID R21AI130653Mar 1, 2017 - Feb 28, 2019
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Srikanth S, Woo JS, Wu B, El-Sherbiny YM, Leung J, Chupradit K, Rice L, Seo GJ, Calmettes G, Ramakrishna C, Cantin E, An DS, Sun R, Wu TT, Jung JU, Savic S, Gwack Y. The Ca2+ sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum. Nat Immunol. 2019 Feb; 20(2):152-162. PMID: 30643259.
      View in: PubMed
    2. Woo JS, Srikanth S, Kim KD, Elsaesser H, Lu J, Pellegrini M, Brooks DG, Sun Z, Gwack Y. CRACR2A-Mediated TCR Signaling Promotes Local Effector Th1 and Th17 Responses. J Immunol. 2018 Aug 15; 201(4):1174-1185. PMID: 29987160.
      View in: PubMed
    3. Choi H, Srikanth S, Atti E, Pirih FQ, Nervina JM, Gwack Y, Tetradis S. Deletion of Orai1 leads to bone loss aggravated with aging and impairs function of osteoblast lineage cells. Bone Rep. 2018 Jun; 8:147-155. PMID: 29955633.
      View in: PubMed
    4. Choi D, Park E, Jung E, Seong YJ, Yoo J, Lee E, Hong M, Lee S, Ishida H, Burford J, Peti-Peterdi J, Adams RH, Srikanth S, Gwack Y, Chen CS, Vogel HJ, Koh CJ, Wong AK, Hong YK. Laminar flow downregulates Notch activity to promote lymphatic sprouting. J Clin Invest. 2017 Apr 03; 127(4):1225-1240. PMID: 28263185.
      View in: PubMed
    5. Choi D, Park E, Jung E, Seong YJ, Hong M, Lee S, Burford J, Gyarmati G, Peti-Peterdi J, Srikanth S, Gwack Y, Koh CJ, Boriushkin E, Hamik A, Wong AK, Hong YK. ORAI1 Activates Proliferation of Lymphatic Endothelial Cells in Response to Laminar Flow Through Krüppel-Like Factors 2 and 4. Circ Res. 2017 Apr 28; 120(9):1426-1439. PMID: 28167653.
      View in: PubMed
    6. Srikanth S, Woo JS, Sun Z, Gwack Y. Immunological Disorders: Regulation of Ca2+ Signaling in T Lymphocytes. Adv Exp Med Biol. 2017; 993:397-424. PMID: 28900926.
      View in: PubMed
    7. Lee SH, Rigas NK, Lee CR, Bang A, Srikanth S, Gwack Y, Kang MK, Kim RH, Park NH, Shin KH. Orai1 promotes tumor progression by enhancing cancer stemness via NFAT signaling in oral/oropharyngeal squamous cell carcinoma. Oncotarget. 2016 Jul 12; 7(28):43239-43255. PMID: 27259269.
      View in: PubMed
    8. Srikanth S, Woo JS, Gwack Y. A large Rab GTPase family in a small GTPase world. Small GTPases. 2017 01 02; 8(1):43-48. PMID: 27221160.
      View in: PubMed
    9. Lee SH, Park Y, Song M, Srikanth S, Kim S, Kang MK, Gwack Y, Park NH, Kim RH, Shin KH. Orai1 mediates osteogenic differentiation via BMP signaling pathway in bone marrow mesenchymal stem cells. Biochem Biophys Res Commun. 2016 05 13; 473(4):1309-1314. PMID: 27086849.
      View in: PubMed
    10. Srikanth S, Kim KD, Gao Y, Woo JS, Ghosh S, Calmettes G, Paz A, Abramson J, Jiang M, Gwack Y. A large Rab GTPase encoded by CRACR2A is a component of subsynaptic vesicles that transmit T cell activation signals. Sci Signal. 2016 Mar 22; 9(420):ra31. PMID: 27016526; PMCID: PMC5013727 [Available on 03/22/17].
    11. Woo JS, Srikanth S, Nishi M, Ping P, Takeshima H, Gwack Y. Junctophilin-4, a component of the endoplasmic reticulum-plasma membrane junctions, regulates Ca2+ dynamics in T cells. Proc Natl Acad Sci U S A. 2016 Mar 08; 113(10):2762-7. PMID: 26929330; PMCID: PMC4790987.
    12. Nurbaeva MK, Eckstein M, Concepcion AR, Smith CE, Srikanth S, Paine ML, Gwack Y, Hubbard MJ, Feske S, Lacruz RS. Dental enamel cells express functional SOCE channels. Sci Rep. 2015 Oct 30; 5:15803. PMID: 26515404; PMCID: PMC4626795.
    13. Bertin S, Aoki-Nonaka Y, de Jong PR, Nohara LL, Xu H, Stanwood SR, Srikanth S, Lee J, To K, Abramson L, Yu T, Han T, Touma R, Li X, González-Navajas JM, Herdman S, Corr M, Fu G, Dong H, Gwack Y, Franco A, Jefferies WA, Raz E. The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4? T cells. Nat Immunol. 2014 Nov; 15(11):1055-1063. PMID: 25282159.
      View in: PubMed
    14. Groenendyk J, Peng Z, Dudek E, Fan X, Mizianty MJ, Dufey E, Urra H, Sepulveda D, Rojas-Rivera D, Lim Y, Kim DH, Baretta K, Srikanth S, Gwack Y, Ahnn J, Kaufman RJ, Lee SK, Hetz C, Kurgan L, Michalak M. Interplay between the oxidoreductase PDIA6 and microRNA-322 controls the response to disrupted endoplasmic reticulum calcium homeostasis. Sci Signal. 2014 Jun 10; 7(329):ra54. PMID: 24917591; PMCID: PMC4984425.
    15. Srikanth S, Kim KD, Gwack Y. Methods to measure cytoplasmic and mitochondrial Ca(2+) concentration using Ca(2+)-sensitive dyes. Methods Enzymol. 2014; 543:1-20. PMID: 24924125.
      View in: PubMed
    16. Kim KD, Srikanth S, Tan YV, Yee MK, Jew M, Damoiseaux R, Jung ME, Shimizu S, An DS, Ribalet B, Waschek JA, Gwack Y. Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation. J Immunol. 2014 Jan 01; 192(1):110-22. PMID: 24307733; PMCID: PMC3874217.
    17. Srikanth S, Gwack Y. Orai1-NFAT signalling pathway triggered by T cell receptor stimulation. Mol Cells. 2013 Mar; 35(3):182-94. PMID: 23483280; PMCID: PMC3887911.
    18. Srikanth S, Ribalet B, Gwack Y. Regulation of CRAC channels by protein interactions and post-translational modification. Channels (Austin). 2013 Sep-Oct; 7(5):354-63. PMID: 23454861; PMCID: PMC3893732.
    19. Srikanth S, Gwack Y. Molecular regulation of the pore component of CRAC channels, Orai1. Curr Top Membr. 2013; 71:181-207. PMID: 23890116.
      View in: PubMed
    20. Srikanth S, Gwack Y. Measurement of intracellular Ca2+ concentration in single cells using ratiometric calcium dyes. Methods Mol Biol. 2013; 963:3-14. PMID: 23296601.
      View in: PubMed
    21. Srikanth S, Jew M, Kim KD, Yee MK, Abramson J, Gwack Y. Junctate is a Ca2+-sensing structural component of Orai1 and stromal interaction molecule 1 (STIM1). Proc Natl Acad Sci U S A. 2012 May 29; 109(22):8682-7. PMID: 22586105; PMCID: PMC3365170.
    22. Srikanth S, Gwack Y. Orai1, STIM1, and their associating partners. J Physiol. 2012 Sep 01; 590(17):4169-77. PMID: 22586216; PMCID: PMC3473276.
    23. Kim KD, Srikanth S, Yee MK, Mock DC, Lawson GW, Gwack Y. ORAI1 deficiency impairs activated T cell death and enhances T cell survival. J Immunol. 2011 Oct 01; 187(7):3620-30. PMID: 21873530; PMCID: PMC3178683.
    24. Srikanth S, Yee MK, Gwack Y, Ribalet B. The third transmembrane segment of orai1 protein modulates Ca2+ release-activated Ca2+ (CRAC) channel gating and permeation properties. J Biol Chem. 2011 Oct 07; 286(40):35318-28. PMID: 21865174; PMCID: PMC3186358.
    25. Newton RH, Leverrier S, Srikanth S, Gwack Y, Cahalan MD, Walsh CM. Protein kinase D orchestrates the activation of DRAK2 in response to TCR-induced Ca2+ influx and mitochondrial reactive oxygen generation. J Immunol. 2011 Jan 15; 186(2):940-50. PMID: 21148796; PMCID: PMC3133617.
    26. Srikanth S, Jung HJ, Kim KD, Souda P, Whitelegge J, Gwack Y. A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells. Nat Cell Biol. 2010 May; 12(5):436-46. PMID: 20418871; PMCID: PMC2875865.
    27. Srikanth S, Jung HJ, Ribalet B, Gwack Y. The intracellular loop of Orai1 plays a central role in fast inactivation of Ca2+ release-activated Ca2+ channels. J Biol Chem. 2010 Feb 12; 285(7):5066-75. PMID: 20007711; PMCID: PMC2836109.
    28. Gwack Y, Srikanth S, Oh-Hora M, Hogan PG, Lamperti ED, Yamashita M, Gelinas C, Neems DS, Sasaki Y, Feske S, Prakriya M, Rajewsky K, Rao A. Hair loss and defective T- and B-cell function in mice lacking ORAI1. Mol Cell Biol. 2008 Sep; 28(17):5209-22. PMID: 18591248; PMCID: PMC2519726.
    29. Barr VA, Bernot KM, Srikanth S, Gwack Y, Balagopalan L, Regan CK, Helman DJ, Sommers CL, Oh-Hora M, Rao A, Samelson LE. Dynamic movement of the calcium sensor STIM1 and the calcium channel Orai1 in activated T-cells: puncta and distal caps. Mol Biol Cell. 2008 Jul; 19(7):2802-17. PMID: 18448669.
      View in: PubMed
    30. Gwack Y, Feske S, Srikanth S, Hogan PG, Rao A. Signalling to transcription: store-operated Ca2+ entry and NFAT activation in lymphocytes. Cell Calcium. 2007 Aug; 42(2):145-56. PMID: 17572487.
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    31. Gwack Y, Srikanth S, Feske S, Cruz-Guilloty F, Oh-hora M, Neems DS, Hogan PG, Rao A. Biochemical and functional characterization of Orai proteins. J Biol Chem. 2007 Jun 01; 282(22):16232-43. PMID: 17293345.
      View in: PubMed
    32. Ong HL, Cheng KT, Liu X, Bandyopadhyay BC, Paria BC, Soboloff J, Pani B, Gwack Y, Srikanth S, Singh BB, Gill DL, Gill D, Ambudkar IS. Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in store-operated calcium influx. Evidence for similarities in store-operated and calcium release-activated calcium channel components. J Biol Chem. 2007 Mar 23; 282(12):9105-16. PMID: 17224452; PMCID: PMC3309402.
    33. Prakriya M, Feske S, Gwack Y, Srikanth S, Rao A, Hogan PG. Orai1 is an essential pore subunit of the CRAC channel. Nature. 2006 Sep 14; 443(7108):230-3. PMID: 16921383.
      View in: PubMed
    34. Banerjee S, Joshi R, Venkiteswaran G, Agrawal N, Srikanth S, Alam F, Hasan G. Compensation of inositol 1,4,5-trisphosphate receptor function by altering sarco-endoplasmic reticulum calcium ATPase activity in the Drosophila flight circuit. J Neurosci. 2006 Aug 09; 26(32):8278-88. PMID: 16899722.
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    35. Feske S, Gwack Y, Prakriya M, Srikanth S, Puppel SH, Tanasa B, Hogan PG, Lewis RS, Daly M, Rao A. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature. 2006 May 11; 441(7090):179-85. PMID: 16582901.
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    36. Gwack Y, Sharma S, Nardone J, Tanasa B, Iuga A, Srikanth S, Okamura H, Bolton D, Feske S, Hogan PG, Rao A. A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT. Nature. 2006 Jun 01; 441(7093):646-50. PMID: 16511445.
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    37. Srikanth S, Banerjee S, Hasan G. Ectopic expression of a Drosophila InsP(3)R channel mutant has dominant-negative effects in vivo. Cell Calcium. 2006 Feb; 39(2):187-96. PMID: 16325255.
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    38. Srikanth S, Wang Z, Hasan G, Bezprozvanny I. Functional properties of a pore mutant in the Drosophila melanogaster inositol 1,4,5-trisphosphate receptor. FEBS Lett. 2004 Sep 24; 575(1-3):95-8. PMID: 15388340.
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    39. Srikanth S, Wang Z, Tu H, Nair S, Mathew MK, Hasan G, Bezprozvanny I. Functional properties of the Drosophila melanogaster inositol 1,4,5-trisphosphate receptor mutants. Biophys J. 2004 Jun; 86(6):3634-46. PMID: 15189860; PMCID: PMC1304265.