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Smale Stephen

TitleVice Dean for Research
InstitutionUniversity of California Los Angeles
DepartmentDavid Geffen School of Medicine at UCLA
Address6-535 MRL
675 Charles E. Young Drive South
Los Angeles CA 90095
Phone(310) 206-4777
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    Other Positions
    TitleDistinguished Professor

    TitleSherie L. and Donald G. Morrison Chair


    Collapse Research 
    Collapse Research Activities and Funding
    FASEB Summer Research Conference on Molecular Mechanisms of Immune Cell Development and Function
    NIH/NIAID R13AI118112May 1, 2015 - Apr 30, 2016
    Role: Principal Investigator
    FASEB SRC on Molecular Mechanisms of Immune Cell Development and Function
    NIH/NIAID R13AI106088Jun 1, 2013 - May 31, 2014
    Role: Co-Principal Investigator
    High throughput screens for modulators of inflammatory cytakine gene expression
    NIH/NIAID R21AI076921May 15, 2009 - Apr 30, 2011
    Role: Principal Investigator
    Pioneer factor interactions in embryonic stem cells
    NIH/NCI R21CA137278May 1, 2009 - Apr 30, 2011
    Role: Principal Investigator
    Selective regulation of pro-inflammatory genes in macrophages
    NIH/NIGMS R01GM086372Sep 30, 2008 - Jul 31, 2016
    Role: Principal Investigator
    Pro-inflammatory gene regulation in a native chromatin environment
    NIH/NCI R01CA127279Jun 1, 2008 - Apr 30, 2012
    Role: Principal Investigator
    Cytokines in Health and Disease: 15th Annual Meeting of the International Cytokin
    NIH/NIAID R13AI077292Oct 24, 2007 - Oct 23, 2008
    Role: Principal Investigator
    Selective gene activation by the NF-kappaB family of transcription factors
    NIH/NIAID R01AI073868Feb 1, 2007 - Jan 31, 2012
    Role: Principal Investigator
    Biological functions and mechanisms of action of Ikaros proteins
    NIH/NIDDK R01DK043726Aug 1, 1996 - Jul 31, 2015
    Role: Principal Investigator
    REGULATION OF TDT EXPRESSION DURING LYMPHOPOIESIS
    NIH/NIDDK R29DK043726May 1, 1991 - Jul 31, 1996
    Role: Principal Investigator
    Medical Scientist Training Program
    NIH/NIGMS T32GM008042Jul 1, 1983 - Jun 30, 2019
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Sallam T, Jones M, Thomas BJ, Wu X, Gilliland T, Qian K, Eskin A, Casero D, Zhang Z, Sandhu J, Salisbury D, Rajbhandari P, Civelek M, Hong C, Ito A, Liu X, Daniel B, Lusis AJ, Whitelegge J, Nagy L, Castrillo A, Smale S, Tontonoz P. Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA. Nat Med. 2018 Mar; 24(3):304-312. PMID: 29431742.
      View in: PubMed
    2. Rajbhandari P, Thomas BJ, Feng AC, Hong C, Wang J, Vergnes L, Sallam T, Wang B, Sandhu J, Seldin MM, Lusis AJ, Fong LG, Katz M, Lee R, Young SG, Reue K, Smale S, Tontonoz P. IL-10 Signaling Remodels Adipose Chromatin Architecture to Limit Thermogenesis and Energy Expenditure. Cell. 2018 Jan 11; 172(1-2):218-233.e17. PMID: 29249357.
      View in: PubMed
    3. Purbey PK, Scumpia PO, Kim PJ, Tong AJ, Iwamoto KS, McBride WH, Smale S. Defined Sensing Mechanisms and Signaling Pathways Contribute to the Global Inflammatory Gene Expression Output Elicited by Ionizing Radiation. Immunity. 2017 09 19; 47(3):421-434.e3. PMID: 28930658.
      View in: PubMed
    4. Madigan CA, Cambier CJ, Kelly-Scumpia KM, Scumpia PO, Cheng TY, Zailaa J, Bloom BR, Moody DB, Smale S, Sagasti A, Modlin RL, Ramakrishnan L. A Macrophage Response to Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage in Leprosy. Cell. 2017 Aug 24; 170(5):973-985.e10. PMID: 28841420.
      View in: PubMed
    5. Scumpia PO, Botten GA, Norman JS, Kelly-Scumpia KM, Spreafico R, Ruccia AR, Purbey PK, Thomas BJ, Modlin RL, Smale S. Opposing roles of Toll-like receptor and cytosolic DNA-STING signaling pathways for Staphylococcus aureus cutaneous host defense. PLoS Pathog. 2017 Jul; 13(7):e1006496. PMID: 28704551.
      View in: PubMed
    6. Schjerven H, Ayongaba EF, Aghajanirefah A, McLaughlin J, Cheng D, Geng H, Boyd JR, Eggesbø LM, Lindeman I, Heath JL, Park E, Witte ON, Smale S, Frietze S, Müschen M. Genetic analysis of Ikaros target genes and tumor suppressor function in BCR-ABL1+ pre-B ALL. J Exp Med. 2017 Mar 06; 214(3):793-814. PMID: 28190001.
      View in: PubMed
    7. Thomas BJ, Smale S. The Ly6C(lo)-Down: Targeting Developmental Enhancers for Cell Subset Depletion. Immunity. 2016 11 15; 45(5):949-951. PMID: 27851919.
      View in: PubMed
    8. Tong AJ, Liu X, Thomas BJ, Lissner MM, Baker MR, Senagolage MD, Allred AL, Barish GD, Smale S. A Stringent Systems Approach Uncovers Gene-Specific Mechanisms Regulating Inflammation. Cell. 2016 Mar 24; 165(1):165-179. PMID: 26924576; PMCID: PMC4808443 [Available on 03/24/17].
    9. Cunningham CR, Champhekar A, Tullius MV, Dillon BJ, Zhen A, de la Fuente JR, Herskovitz J, Elsaesser H, Snell LM, Wilson EB, de la Torre JC, Kitchen SG, Horwitz MA, Bensinger SJ, Smale S, Brooks DG. Type I and Type II Interferon Coordinately Regulate Suppressive Dendritic Cell Fate and Function during Viral Persistence. PLoS Pathog. 2016 Jan; 12(1):e1005356. PMID: 26808628; PMCID: PMC4726812.
    10. Kayama H, Ramirez-Carrozzi VR, Yamamoto M, Mizutani T, Kuwata H, Iba H, Matsumoto M, Honda K, Smale S, Takeda K. Class-specific regulation of pro-inflammatory genes by MyD88 pathways and I?B?. J Biol Chem. 2015 Sep 11; 290(37):22446. PMID: 26362542; PMCID: PMC4566219.
    11. Arenzana TL, Schjerven H, Smale S. Regulation of gene expression dynamics during developmental transitions by the Ikaros transcription factor. Genes Dev. 2015 Sep 01; 29(17):1801-16. PMID: 26314708; PMCID: PMC4573854.
    12. Lissner MM, Thomas BJ, Wee K, Tong AJ, Kollmann TR, Smale S. Age-Related Gene Expression Differences in Monocytes from Human Neonates, Young Adults, and Older Adults. PLoS One. 2015; 10(7):e0132061. PMID: 26147648; PMCID: PMC4493075.
    13. Fowler T, Garruss AS, Ghosh A, De S, Becker KG, Wood WH, Weirauch MT, Smale S, Aronow B, Sen R, Roy AL. Divergence of transcriptional landscape occurs early in B cell activation. Epigenetics Chromatin. 2015; 8:20. PMID: 25987903; PMCID: PMC4434543.
    14. Kayama H, Ramirez-Carrozzi VR, Yamamoto M, Mizutani T, Kuwata H, Iba H, Matsumoto M, Honda K, Smale S, Takeda K. Class-specific regulation of pro-inflammatory genes by MyD88 pathways and I?B?. J Biol Chem. 2015 Feb 20; 290(8):4815. PMID: 25713407; PMCID: PMC4335220.
    15. Smale S, Natoli G. Transcriptional control of inflammatory responses. Cold Spring Harb Perspect Biol. 2014 Sep 11; 6(11):a016261. PMID: 25213094.
      View in: PubMed
    16. Heller JJ, Schjerven H, Li S, Lee A, Qiu J, Chen ZM, Smale S, Zhou L. Restriction of IL-22-producing T cell responses and differential regulation of regulatory T cell compartments by zinc finger transcription factor Ikaros. J Immunol. 2014 Oct 15; 193(8):3934-46. PMID: 25194055; PMCID: PMC4185244.
    17. Smale S, Plevy SE, Weinmann AS, Zhou L, Ramirez-Carrozzi VR, Pope SD, Bhatt DM, Tong AJ. Toward an understanding of the gene-specific and global logic of inducible gene transcription. Cold Spring Harb Symp Quant Biol. 2013; 78:61-8. PMID: 24747344.
      View in: PubMed
    18. Smale S. Transcriptional regulation in the immune system: a status report. Trends Immunol. 2014 May; 35(5):190-4. PMID: 24703179; PMCID: PMC4041609.
    19. Garcia AJ, Ruscetti M, Arenzana TL, Tran LM, Bianci-Frias D, Sybert E, Priceman SJ, Wu L, Nelson PS, Smale S, Wu H. Pten null prostate epithelium promotes localized myeloid-derived suppressor cell expansion and immune suppression during tumor initiation and progression. Mol Cell Biol. 2014 Jun; 34(11):2017-28. PMID: 24662052; PMCID: PMC4019050.
    20. Shen WJ, Wei YT, Guo X, Smale S, Wong HS, Li SC. MHC binding prediction with KernelRLSpan and its variations. J Immunol Methods. 2014 Apr; 406:10-20. PMID: 24603003.
      View in: PubMed
    21. Smale S, Tarakhovsky A, Natoli G. Chromatin contributions to the regulation of innate immunity. Annu Rev Immunol. 2014; 32:489-511. PMID: 24555473.
      View in: PubMed
    22. Schjerven H, McLaughlin J, Arenzana TL, Frietze S, Cheng D, Wadsworth SE, Lawson GW, Bensinger SJ, Farnham PJ, Witte ON, Smale S. Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros. Nat Immunol. 2013 Oct; 14(10):1073-83. PMID: 24013668; PMCID: PMC3800053.
    23. Carey MF, Peterson CL, Smale S. PCR-mediated site-directed mutagenesis. Cold Spring Harb Protoc. 2013 Aug 01; 2013(8):738-42. PMID: 23906918.
      View in: PubMed
    24. Carey MF, Peterson CL, Smale S. Electrophoretic mobility-shift assays. Cold Spring Harb Protoc. 2013 Jul 01; 2013(7):636-9. PMID: 23818676.
      View in: PubMed
    25. Carey MF, Peterson CL, Smale S. DNase I footprinting. Cold Spring Harb Protoc. 2013 May 01; 2013(5):469-78. PMID: 23637368.
      View in: PubMed
    26. Carey MF, Peterson CL, Smale S. Preparation of (32)P-end-labeled DNA fragments for performing DNA-binding experiments. Cold Spring Harb Protoc. 2013 May 01; 2013(5):464-8. PMID: 23637369.
      View in: PubMed
    27. Pandya-Jones A, Bhatt DM, Lin CH, Tong AJ, Smale S, Black DL. Splicing kinetics and transcript release from the chromatin compartment limit the rate of Lipid A-induced gene expression. RNA. 2013 Jun; 19(6):811-27. PMID: 23616639; PMCID: PMC3683915.
    28. Carey MF, Peterson CL, Smale S. The RNase protection assay. Cold Spring Harb Protoc. 2013 Mar 01; 2013(3). PMID: 23457339.
      View in: PubMed
    29. Carey MF, Peterson CL, Smale S. The primer extension assay. Cold Spring Harb Protoc. 2013 Feb 01; 2013(2):164-73. PMID: 23378648.
      View in: PubMed
    30. Ferreirós-Vidal I, Carroll T, Taylor B, Terry A, Liang Z, Bruno L, Dharmalingam G, Khadayate S, Cobb BS, Smale S, Spivakov M, Srivastava P, Petretto E, Fisher AG, Merkenschlager M. Genome-wide identification of Ikaros targets elucidates its contribution to mouse B-cell lineage specification and pre-B-cell differentiation. Blood. 2013 Mar 07; 121(10):1769-82. PMID: 23303821.
      View in: PubMed
    31. Xu J, Smale S. Designing an enhancer landscape. Cell. 2012 Nov 21; 151(5):929-31. PMID: 23178114; PMCID: PMC3732118.
    32. Koshiba R, Yanai H, Matsuda A, Goto A, Nakajima A, Negishi H, Nishio J, Smale S, Taniguchi T. Regulation of cooperative function of the Il12b enhancer and promoter by the interferon regulatory factors 3 and 5. Biochem Biophys Res Commun. 2013 Jan 04; 430(1):95-100. PMID: 23154183.
      View in: PubMed
    33. Murray PJ, Smale S. Restraint of inflammatory signaling by interdependent strata of negative regulatory pathways. Nat Immunol. 2012 Oct; 13(10):916-24. PMID: 22990889; PMCID: PMC4893774.
    34. Bhatt DM, Pandya-Jones A, Tong AJ, Barozzi I, Lissner MM, Natoli G, Black DL, Smale S. Transcript dynamics of proinflammatory genes revealed by sequence analysis of subcellular RNA fractions. Cell. 2012 Jul 20; 150(2):279-90. PMID: 22817891; PMCID: PMC3405548.
    35. Carey MF, Peterson CL, Smale S. Confirming the functional importance of a protein-DNA interaction. Cold Spring Harb Protoc. 2012 Jul 01; 2012(7):733-57. PMID: 22753608.
      View in: PubMed
    36. Negishi H, Yanai H, Nakajima A, Koshiba R, Atarashi K, Matsuda A, Matsuki K, Miki S, Doi T, Aderem A, Nishio J, Smale S, Honda K, Taniguchi T. Cross-interference of RLR and TLR signaling pathways modulates antibacterial T cell responses. Nat Immunol. 2012 May 20; 13(7):659-66. PMID: 22610141.
      View in: PubMed
    37. Carey MF, Peterson CL, Smale S. Identifying cis-acting DNA elements within a control region. Cold Spring Harb Protoc. 2012 Mar 01; 2012(3):279-96. PMID: 22383646.
      View in: PubMed
    38. Smale S. Dimer-specific regulatory mechanisms within the NF-?B family of transcription factors. Immunol Rev. 2012 Mar; 246(1):193-204. PMID: 22435556.
      View in: PubMed
    39. Carey MF, Peterson CL, Smale S. Experimental strategies for cloning or identifying genes encoding DNA-binding proteins. Cold Spring Harb Protoc. 2012 Feb 01; 2012(2):183-92. PMID: 22301659.
      View in: PubMed
    40. Smale S. Transcriptional regulation in the innate immune system. Curr Opin Immunol. 2012 Feb; 24(1):51-7. PMID: 22230561; PMCID: PMC3288296.
    41. Carey MF, Peterson CL, Smale S. Experimental strategies for the identification of DNA-binding proteins. Cold Spring Harb Protoc. 2012 Jan 01; 2012(1):18-33. PMID: 22194258.
      View in: PubMed
    42. Siggers T, Chang AB, Teixeira A, Wong D, Williams KJ, Ahmed B, Ragoussis J, Udalova IA, Smale S, Bulyk ML. Principles of dimer-specific gene regulation revealed by a comprehensive characterization of NF-?B family DNA binding. Nat Immunol. 2011 Nov 20; 13(1):95-102. PMID: 22101729.
      View in: PubMed
    43. Smale S. Hierarchies of NF-?B target-gene regulation. Nat Immunol. 2011 Jul 19; 12(8):689-94. PMID: 21772277; PMCID: PMC3169328.
    44. Smith AM, Qualls JE, O'Brien K, Balouzian L, Johnson PF, Schultz-Cherry S, Smale S, Murray PJ. A distal enhancer in Il12b is the target of transcriptional repression by the STAT3 pathway and requires the basic leucine zipper (B-ZIP) protein NFIL3. J Biol Chem. 2011 Jul 01; 286(26):23582-90. PMID: 21566115; PMCID: PMC3123121.
    45. Kobayashi T, Matsuoka K, Sheikh SZ, Elloumi HZ, Kamada N, Hisamatsu T, Hansen JJ, Doty KR, Pope SD, Smale S, Hibi T, Rothman PB, Kashiwada M, Plevy SE. NFIL3 is a regulator of IL-12 p40 in macrophages and mucosal immunity. J Immunol. 2011 Apr 15; 186(8):4649-55. PMID: 21383239; PMCID: PMC3172700.
    46. Carey MF, Peterson CL, Smale S. Magnesium-agarose electrophoretic mobility shift assay (EMSA) of transcription factor IID binding to DNA. Cold Spring Harb Protoc. 2010 Nov 01; 2010(11):pdb.prot5514. PMID: 21041387.
      View in: PubMed
    47. Mukhopadhyay S, Plüddemann A, Hoe JC, Williams KJ, Varin A, Makepeace K, Aknin ML, Bowdish DM, Smale S, Barclay AN, Gordon S. Immune inhibitory ligand CD200 induction by TLRs and NLRs limits macrophage activation to protect the host from meningococcal septicemia. Cell Host Microbe. 2010 Sep 16; 8(3):236-47. PMID: 20833375.
      View in: PubMed
    48. Carey MF, Peterson CL, Smale S. Protein complex binding to promoter DNA: immobilized template assay. Cold Spring Harb Protoc. 2010 Aug 01; 2010(8):pdb.prot5465. PMID: 20679374.
      View in: PubMed
    49. Carey MF, Peterson CL, Smale S. Potassium permanganate probing of Pol II open complexes. Cold Spring Harb Protoc. 2010 Aug 01; 2010(8):pdb.prot5479. PMID: 20679388.
      View in: PubMed
    50. Smale S. Pioneer factors in embryonic stem cells and differentiation. Curr Opin Genet Dev. 2010 Oct; 20(5):519-26. PMID: 20638836; PMCID: PMC2943026.
    51. Carey MF, Peterson CL, Smale S. Purification of epitope-tagged transcription factor IID. Cold Spring Harb Protoc. 2010 Jul 01; 2010(7):pdb.prot5450. PMID: 20647354.
      View in: PubMed
    52. Carey MF, Peterson CL, Smale S. Purification of mediator from HeLa cell lines expressing a flag-tagged mediator subunit. Cold Spring Harb Protoc. 2010 Jul 01; 2010(7):pdb.prot5451. PMID: 20647355.
      View in: PubMed
    53. Smale S. Luciferase assay. Cold Spring Harb Protoc. 2010 May; 2010(5):pdb.prot5421. PMID: 20439408.
      View in: PubMed
    54. Smale S. Chloramphenicol acetyltransferase assay. Cold Spring Harb Protoc. 2010 May; 2010(5):pdb.prot5422. PMID: 20439409.
      View in: PubMed
    55. Smale S. Beta-galactosidase assay. Cold Spring Harb Protoc. 2010 May; 2010(5):pdb.prot5423. PMID: 20439410.
      View in: PubMed
    56. Smale S. Seq-ing LPS-induced enhancers. Immunity. 2010 Mar 26; 32(3):296-8. PMID: 20346768.
      View in: PubMed
    57. Smale S. Selective transcription in response to an inflammatory stimulus. Cell. 2010 Mar 19; 140(6):833-44. PMID: 20303874; PMCID: PMC2847629.
    58. Carey MF, Peterson CL, Smale S. G-less cassette in vitro transcription using HeLa cell nuclear extracts. Cold Spring Harb Protoc. 2010 Mar; 2010(3):pdb.prot5387. PMID: 20194456.
      View in: PubMed
    59. Smale S. Calcium phosphate transfection of 3T3 fibroblasts. Cold Spring Harb Protoc. 2010 Feb; 2010(2):pdb.prot5372. PMID: 20150135.
      View in: PubMed
    60. Smale S. DEAE-dextran transfection of lymphocyte cell lines. Cold Spring Harb Protoc. 2010 Feb; 2010(2):pdb.prot5373. PMID: 20150136.
      View in: PubMed
    61. Smale S. Transfection by electroporation of RAW 264.7 macrophages. Cold Spring Harb Protoc. 2010 Feb; 2010(2):pdb.prot5374. PMID: 20150137.
      View in: PubMed
    62. Xu J, Watts JA, Pope SD, Gadue P, Kamps M, Plath K, Zaret KS, Smale S. Transcriptional competence and the active marking of tissue-specific enhancers by defined transcription factors in embryonic and induced pluripotent stem cells. Genes Dev. 2009 Dec 15; 23(24):2824-38. PMID: 20008934; PMCID: PMC2800090.
    63. Papathanasiou P, Attema JL, Karsunky H, Hosen N, Sontani Y, Hoyne GF, Tunningley R, Smale S, Weissman IL. Self-renewal of the long-term reconstituting subset of hematopoietic stem cells is regulated by Ikaros. Stem Cells. 2009 Dec; 27(12):3082-92. PMID: 19816952; PMCID: PMC3401049.
    64. Carey MF, Peterson CL, Smale S. Dignam and Roeder nuclear extract preparation. Cold Spring Harb Protoc. 2009 Dec; 2009(12):pdb.prot5330. PMID: 20150077.
      View in: PubMed
    65. Carey MF, Peterson CL, Smale S. In vitro transcription using HeLa cell extracts and primer extension. Cold Spring Harb Protoc. 2009 Dec; 2009(12):pdb.prot5331. PMID: 20150078.
      View in: PubMed
    66. Smale S. Nuclear run-on assay. Cold Spring Harb Protoc. 2009 Nov; 2009(11):pdb.prot5329. PMID: 20150068.
      View in: PubMed
    67. Sen R, Smale S. Selectivity of the NF-{kappa}B response. Cold Spring Harb Perspect Biol. 2010 Apr; 2(4):a000257. PMID: 20452937; PMCID: PMC2845200.
    68. Papathanasiou P, Attema JL, Karsunky H, Xu J, Smale S, Weissman IL. Evaluation of the long-term reconstituting subset of hematopoietic stem cells with CD150. Stem Cells. 2009 Oct; 27(10):2498-508. PMID: 19593793; PMCID: PMC2783507.
    69. Carey MF, Peterson CL, Smale S. In vivo DNase I, MNase, and restriction enzyme footprinting via ligation-mediated polymerase chain reaction (LM-PCR). Cold Spring Harb Protoc. 2009 Sep; 2009(9):pdb.prot5277. PMID: 20147262.
      View in: PubMed
    70. Carey MF, Peterson CL, Smale S. In vivo dimethyl sulfate (DMS) footprinting via ligation-mediated polymerase chain reaction (LM-PCR). Cold Spring Harb Protoc. 2009 Sep; 2009(9):pdb.prot5278. PMID: 20147263.
      View in: PubMed
    71. Carey MF, Peterson CL, Smale S. Chromatin immunoprecipitation (ChIP). Cold Spring Harb Protoc. 2009 Sep; 2009(9):pdb.prot5279. PMID: 20147264.
      View in: PubMed
    72. Ramirez-Carrozzi VR, Braas D, Bhatt DM, Cheng CS, Hong C, Doty KR, Black JC, Hoffmann A, Carey M, Smale S. A unifying model for the selective regulation of inducible transcription by CpG islands and nucleosome remodeling. Cell. 2009 Jul 10; 138(1):114-28. PMID: 19596239; PMCID: PMC2712736.
    73. Reynaud D, Demarco IA, Reddy KL, Schjerven H, Bertolino E, Chen Z, Smale S, Winandy S, Singh H. Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros. Nat Immunol. 2008 Aug; 9(8):927-36. PMID: 18568028; PMCID: PMC2699484.
    74. Kayama H, Ramirez-Carrozzi VR, Yamamoto M, Mizutani T, Kuwata H, Iba H, Matsumoto M, Honda K, Smale S, Takeda K. Class-specific regulation of pro-inflammatory genes by MyD88 pathways and IkappaBzeta. J Biol Chem. 2008 May 02; 283(18):12468-77. PMID: 18319258.
      View in: PubMed
    75. Carey M, Smale S. Hydroxyl-radical footprinting. CSH Protoc. 2007 Dec 01; 2007:pdb.prot4810. PMID: 21356993.
      View in: PubMed
    76. Carey M, Smale S. Phosphate ethylation interference assay. CSH Protoc. 2007 Dec 01; 2007:pdb.prot4811. PMID: 21356994.
      View in: PubMed
    77. Carey M, Smale S. Methylation interference assay. CSH Protoc. 2007 Dec 01; 2007:pdb.prot4812. PMID: 21356995.
      View in: PubMed
    78. Carey M, Smale S. Micrococcal Nuclease-Southern Blot Assay: II. Capillary Transfer and Hybridization. CSH Protoc. 2007 Nov 01; 2007:pdb.prot4891. PMID: 21356982.
      View in: PubMed
    79. Carey M, Smale S. Micrococcal Nuclease-Southern Blot Assay: I. MNase and Restriction Digestions. CSH Protoc. 2007 Nov 01; 2007:pdb.prot4890. PMID: 21356981.
      View in: PubMed
    80. Sridharan R, Smale S. Predominant interaction of both Ikaros and Helios with the NuRD complex in immature thymocytes. J Biol Chem. 2007 Oct 12; 282(41):30227-38. PMID: 17681952.
      View in: PubMed
    81. Attema JL, Papathanasiou P, Forsberg EC, Xu J, Smale S, Weissman IL. Epigenetic characterization of hematopoietic stem cell differentiation using miniChIP and bisulfite sequencing analysis. Proc Natl Acad Sci U S A. 2007 Jul 24; 104(30):12371-6. PMID: 17640913; PMCID: PMC1924790.
    82. Xu J, Pope SD, Jazirehi AR, Attema JL, Papathanasiou P, Watts JA, Zaret KS, Weissman IL, Smale S. Pioneer factor interactions and unmethylated CpG dinucleotides mark silent tissue-specific enhancers in embryonic stem cells. Proc Natl Acad Sci U S A. 2007 Jul 24; 104(30):12377-82. PMID: 17640912; PMCID: PMC1941477.
    83. Thompson EC, Cobb BS, Sabbattini P, Meixlsperger S, Parelho V, Liberg D, Taylor B, Dillon N, Georgopoulos K, Jumaa H, Smale S, Fisher AG, Merkenschlager M. Ikaros DNA-binding proteins as integral components of B cell developmental-stage-specific regulatory circuits. Immunity. 2007 Mar; 26(3):335-44. PMID: 17363301.
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    84. Zhou L, Nazarian AA, Xu J, Tantin D, Corcoran LM, Smale S. An inducible enhancer required for Il12b promoter activity in an insulated chromatin environment. Mol Cell Biol. 2007 Apr; 27(7):2698-712. PMID: 17242186; PMCID: PMC1899891.
    85. Cobb BS, Hertweck A, Smith J, O'Connor E, Graf D, Cook T, Smale S, Sakaguchi S, Livesey FJ, Fisher AG, Merkenschlager M. A role for Dicer in immune regulation. J Exp Med. 2006 Oct 30; 203(11):2519-27. PMID: 17060477; PMCID: PMC2118134.
    86. Li CC, Ramirez-Carrozzi VR, Smale S. Pursuing gene regulation 'logic' via RNA interference and chromatin immunoprecipitation. Nat Immunol. 2006 Jul; 7(7):692-7. PMID: 16785883.
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    87. Smale S, Dorshkind K. Hematopoiesis flies high with Ikaros. Nat Immunol. 2006 Apr; 7(4):367-9. PMID: 16550201.
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    88. Ramirez-Carrozzi VR, Nazarian AA, Li CC, Gore SL, Sridharan R, Imbalzano AN, Smale S. Selective and antagonistic functions of SWI/SNF and Mi-2beta nucleosome remodeling complexes during an inflammatory response. Genes Dev. 2006 Feb 01; 20(3):282-96. PMID: 16452502; PMCID: PMC1361700.
    89. Dovat S, Montecino-Rodriguez E, Schuman V, Teitell MA, Dorshkind K, Smale S. Transgenic expression of Helios in B lineage cells alters B cell properties and promotes lymphomagenesis. J Immunol. 2005 Sep 15; 175(6):3508-15. PMID: 16148093.
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    90. Sanjabi S, Williams KJ, Saccani S, Zhou L, Hoffmann A, Ghosh G, Gerondakis S, Natoli G, Smale S. A c-Rel subdomain responsible for enhanced DNA-binding affinity and selective gene activation. Genes Dev. 2005 Sep 15; 19(18):2138-51. PMID: 16166378; PMCID: PMC1221885.
    91. Cobb BS, Nesterova TB, Thompson E, Hertweck A, O'Connor E, Godwin J, Wilson CB, Brockdorff N, Fisher AG, Smale S, Merkenschlager M. T cell lineage choice and differentiation in the absence of the RNase III enzyme Dicer. J Exp Med. 2005 May 02; 201(9):1367-73. PMID: 15867090; PMCID: PMC2213187.
    92. Su RC, Sridharan R, Smale S. Assembly of silent chromatin during thymocyte development. Semin Immunol. 2005 Apr; 17(2):129-40. PMID: 15737574.
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    93. Su RC, Brown KE, Saaber S, Fisher AG, Merkenschlager M, Smale S. Dynamic assembly of silent chromatin during thymocyte maturation. Nat Genet. 2004 May; 36(5):502-6. PMID: 15098035.
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    94. Zhou L, Nazarian AA, Smale S. Interleukin-10 inhibits interleukin-12 p40 gene transcription by targeting a late event in the activation pathway. Mol Cell Biol. 2004 Mar; 24(6):2385-96. PMID: 14993278; PMCID: PMC355839.
    95. Cupit PM, Hansen JD, McCarty AS, White G, Chioda M, Spada F, Smale S, Cunningham C. Ikaros family members from the agnathan Myxine glutinosa and the urochordate Oikopleura dioica: emergence of an essential transcription factor for adaptive immunity. J Immunol. 2003 Dec 01; 171(11):6006-13. PMID: 14634112.
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    96. Liberg D, Smale S, Merkenschlager M. Upstream of Ikaros. Trends Immunol. 2003 Nov; 24(11):567-70. PMID: 14596876.
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    97. Smale S. A Th2 cytokine LCR. Adding a new piece to the regulatory puzzle. Immunity. 2003 Jul; 19(1):1-2. PMID: 12871632.
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    98. Papathanasiou P, Perkins AC, Cobb BS, Ferrini R, Sridharan R, Hoyne GF, Nelms KA, Smale S, Goodnow CC. Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros transcription factor. Immunity. 2003 Jul; 19(1):131-44. PMID: 12871645.
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    99. Bradley MN, Zhou L, Smale S. C/EBPbeta regulation in lipopolysaccharide-stimulated macrophages. Mol Cell Biol. 2003 Jul; 23(14):4841-58. PMID: 12832471; PMCID: PMC162211.
    100. Smale S. The establishment and maintenance of lymphocyte identity through gene silencing. Nat Immunol. 2003 Jul; 4(7):607-15. PMID: 12830135.
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    101. Ronni T, Agarwal V, Haykinson M, Haberland ME, Cheng G, Smale S. Common interaction surfaces of the toll-like receptor 4 cytoplasmic domain stimulate multiple nuclear targets. Mol Cell Biol. 2003 Apr; 23(7):2543-55. PMID: 12640135; PMCID: PMC150739.
    102. Smale S, Kadonaga JT. The RNA polymerase II core promoter. Annu Rev Biochem. 2003; 72:449-79. PMID: 12651739.
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    103. McCarty AS, Kleiger G, Eisenberg D, Smale S. Selective dimerization of a C2H2 zinc finger subfamily. Mol Cell. 2003 Feb; 11(2):459-70. PMID: 12620233.
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    104. Dovat S, Ronni T, Russell D, Ferrini R, Cobb BS, Smale S. A common mechanism for mitotic inactivation of C2H2 zinc finger DNA-binding domains. Genes Dev. 2002 Dec 01; 16(23):2985-90. PMID: 12464629; PMCID: PMC187490.
    105. Smale S, Fisher AG. Chromatin structure and gene regulation in the immune system. Annu Rev Immunol. 2002; 20:427-62. PMID: 11861609.
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