Arumugaswami Vaithilingaraja

Title(s)Member, CTSI
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    Title(s)Adjunct Assistant Professor, Molecular & Medical Pharmacology

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Thaker SK, Chapa T, Garcia G, Gong D, Schmid EW, Arumugaswami V, Sun R, Christofk HR. Differential Metabolic Reprogramming by Zika Virus Promotes Cell Death in Human versus Mosquito Cells. Cell Metab. 2019 Feb 16. PMID: 30827860.
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    2. Zin AA, Tsui I, Rossetto JD, Gaw SL, Neves LM, Zin OA, Haefeli L, Barros Silveira Filho JC, Adachi K, Vinicius da Silva Pone M, Pone SM, Molleri N, Pereira JP, Belfort R, Arumugaswami V, Vasconcelos Z, Brasil P, Nielsen-Saines K, Lopes Moreira ME. Visual function in infants with antenatal Zika virus exposure. J AAPOS. 2018 Dec; 22(6):452-456.e1. PMID: 30359768.
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    3. Tsui I, Moreira MEL, Rossetto JD, Vasconcelos Z, Gaw SL, Neves LM, Zin OA, Haefeli L, Silveira Filho JCB, Gomes SC, Adachi K, Pone MVDS, Pone SM, Pereira JP, Belfort R, Arumugaswami V, Brasil P, Nielsen-Saines K, Zin AA. Eye Findings in Infants With Suspected or Confirmed Antenatal Zika Virus Exposure. Pediatrics. 2018 Oct; 142(4). PMID: 30213843.
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    4. Khachatoorian R, Cohn W, Buzzanco A, Riahi R, Arumugaswami V, Dasgupta A, Whitelegge JP, French SW. HSP70 Copurifies with Zika Virus Particles. Virology. 2018 09; 522:228-233. PMID: 30053656.
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    5. Singh PK, Khatri I, Jha A, Pretto CD, Spindler KR, Arumugaswami V, Giri S, Kumar A, Bhasin MK. Determination of system level alterations in host transcriptome due to Zika virus (ZIKV) Infection in retinal pigment epithelium. Sci Rep. 2018 Jul 25; 8(1):11209. PMID: 30046058.
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    6. Lu NT, Liu NM, Patel D, Vu JQ, Liu L, Kim CY, Cho P, Khachatoorian R, Patel N, Magyar CE, Ganapathy E, Arumugaswami V, Dasgupta A, French SW. Oncoprotein Stathmin Modulates Sensitivity to Apoptosis in Hepatocellular Carcinoma Cells During Hepatitis C Viral Replication. J Cell Death. 2018; 11:1179066018785141. PMID: 30034249.
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    7. Gong D, Zhang TH, Zhao D, Du Y, Chapa TJ, Shi Y, Wang L, Contreras D, Zeng G, Shi PY, Wu TT, Arumugaswami V, Sun R. High-Throughput Fitness Profiling of Zika Virus E Protein Reveals Different Roles for Glycosylation during Infection of Mammalian and Mosquito Cells. iScience. 2018 Mar 23; 1:97-111. PMID: 30227960.
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    8. Ehrhardt N, Doche ME, Chen S, Mao HZ, Walsh MT, Bedoya C, Guindi M, Xiong W, Ignatius Irudayam J, Iqbal J, Fuchs S, French SW, Mahmood Hussain M, Arditi M, Arumugaswami V, Péterfy M. Hepatic Tm6sf2 overexpression affects cellular ApoB-trafficking, plasma lipid levels, hepatic steatosis and atherosclerosis. Hum Mol Genet. 2017 07 15; 26(14):2719-2731. PMID: 28449094.
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    9. Subramanian ER, Gopi Daisy N, Sudalaimani DK, Ramamoorthy K, Balakrishnan S, Selvan Christyraj JD, Arumugaswami V, Sivasubramaniam S. Function of translationally controlled tumor protein (TCTP) in Eudrilus eugeniae regeneration. PLoS One. 2017; 12(4):e0175319. PMID: 28403226.
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    10. Ramaiah A, Dai L, Contreras D, Sinha S, Sun R, Arumugaswami V. Comparative analysis of protein evolution in the genome of pre-epidemic and epidemic Zika virus. Infect Genet Evol. 2017 07; 51:74-85. PMID: 28315476.
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    11. Qi H, Chu V, Wu NC, Chen Z, Truong S, Brar G, Su SY, Du Y, Arumugaswami V, Olson CA, Chen SH, Lin CY, Wu TT, Sun R. Systematic identification of anti-interferon function on hepatitis C virus genome reveals p7 as an immune evasion protein. Proc Natl Acad Sci U S A. 2017 02 21; 114(8):2018-2023. PMID: 28159892.
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    12. Talavera-Adame D, Woolcott OO, Ignatius-Irudayam J, Arumugaswami V, Geller DH, Dafoe DC. Erratum to: Effective endothelial cell and human pluripotent stem cell interactions generate functional insulin-producing beta cells. Diabetologia. 2016 12; 59(12):2730. PMID: 27752711.
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    13. Talavera-Adame D, Woolcott OO, Ignatius-Irudayam J, Arumugaswami V, Geller DH, Dafoe DC. Effective endothelial cell and human pluripotent stem cell interactions generate functional insulin-producing beta cells. Diabetologia. 2016 11; 59(11):2378-2386. PMID: 27567623.
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    14. Contreras D, Arumugaswami V. Zika Virus Infectious Cell Culture System and the In Vitro Prophylactic Effect of Interferons. J Vis Exp. 2016 08 23; (114). PMID: 27584546.
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    15. Gopi Daisy N, Subramanian ER, Selvan Christyraj JD, Sudalai Mani DK, Selvan Christyraj JR, Ramamoorthy K, Arumugaswami V, Sivasubramaniam S. Studies on regeneration of central nervous system and social ability of the earthworm Eudrilus eugeniae. Invert Neurosci. 2016 09; 16(3):6. PMID: 27279085.
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    16. Khachatoorian R, Riahi R, Ganapathy E, Shao H, Wheatley NM, Sundberg C, Jung CL, Ruchala P, Dasgupta A, Arumugaswami V, Gestwicki JE, French SW. Allosteric heat shock protein 70 inhibitors block hepatitis C virus assembly. Int J Antimicrob Agents. 2016 Apr; 47(4):289-96. PMID: 27013001; PMCID: PMC4833571 [Available on 04/01/17].
    17. Ramaiah A, Arumugaswami V. Ebolavirus evolves in human to minimize the detection by immune cells by accumulating adaptive mutations. Virusdisease. 2016 Jun; 27(2):136-44. PMID: 27366764; PMCID: PMC4908996 [Available on 06/01/17].
    18. Ignatius Irudayam J, Contreras D, Spurka L, Ren S, Kanagavel V, Ramaiah A, Annamalai A, French SW, Klein AS, Funari V, Arumugaswami V. Profile of Inflammation-associated genes during Hepatic Differentiation of Human Pluripotent Stem Cells. Data Brief. 2015 Dec; 5:871-8. PMID: 26702414; PMCID: PMC4669432.
    19. Irudayam JI, Contreras D, Spurka L, Subramanian A, Allen J, Ren S, Kanagavel V, Nguyen Q, Ramaiah A, Ramamoorthy K, French SW, Klein AS, Funari V, Arumugaswami V. Characterization of type I interferon pathway during hepatic differentiation of human pluripotent stem cells and hepatitis C virus infection. Stem Cell Res. 2015 Sep; 15(2):354-364. PMID: 26313525; PMCID: PMC4600668.
    20. Hatada S, Subramanian A, Mandefro B, Ren S, Kim HW, Tang J, Funari V, Baloh RH, Sareen D, Arumugaswami V, Svendsen CN. Low-Dose Irradiation Enhances Gene Targeting in Human Pluripotent Stem Cells. Stem Cells Transl Med. 2015 Sep; 4(9):998-1010. PMID: 26185257; PMCID: PMC4542875.
    21. Khachatoorian R, Ruchala P, Waring A, Jung CL, Ganapathy E, Wheatley N, Sundberg C, Arumugaswami V, Dasgupta A, French SW. Structural characterization of the HSP70 interaction domain of the hepatitis C viral protein NS5A. Virology. 2015 Jan 15; 475:46-55. PMID: 25462345; PMCID: PMC4284078.
    22. Remenyi R, Qi H, Su SY, Chen Z, Wu NC, Arumugaswami V, Truong S, Chu V, Stokelman T, Lo HH, Olson CA, Wu TT, Chen SH, Lin CY, Sun R. A comprehensive functional map of the hepatitis C virus genome provides a resource for probing viral proteins. MBio. 2014 Sep 30; 5(5):e01469-14. PMID: 25271282; PMCID: PMC4196222.
    23. Kurtovic S, Ng TT, Gupta A, Arumugaswami V, Chaiboonma KL, Aminzadeh MA, Makkar R, Dafoe DC, Talavera-Adame D. Leptin enhances endothelial cell differentiation and angiogenesis in murine embryonic stem cells. Microvasc Res. 2015 Jan; 97:65-74. PMID: 25250519.
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    24. Ren S, Contreras D, Arumugaswami V. A protocol for analyzing hepatitis C virus replication. J Vis Exp. 2014 Jun 26; (88):e51362. PMID: 24998302; PMCID: PMC4206077.
    25. Khachatoorian R, Ganapathy E, Ahmadieh Y, Wheatley N, Sundberg C, Jung CL, Arumugaswami V, Raychaudhuri S, Dasgupta A, French SW. The NS5A-binding heat shock proteins HSC70 and HSP70 play distinct roles in the hepatitis C viral life cycle. Virology. 2014 Apr; 454-455:118-27. PMID: 24725938; PMCID: PMC4011396.
    26. Dolan PT, Zhang C, Khadka S, Arumugaswami V, Vangeloff AD, Heaton NS, Sahasrabudhe S, Randall G, Sun R, LaCount DJ. Identification and comparative analysis of hepatitis C virus-host cell protein interactions. Mol Biosyst. 2013 Dec; 9(12):3199-209. PMID: 24136289; PMCID: PMC4171131.
    27. Talavera-Adame D, Gupta A, Kurtovic S, Chaiboonma KL, Arumugaswami V, Dafoe DC. Bone morphogenetic protein-2/-4 upregulation promoted by endothelial cells in coculture enhances mouse embryoid body differentiation. Stem Cells Dev. 2013 Dec 15; 22(24):3252-60. PMID: 23924071; PMCID: PMC3868407.
    28. Lassmann B, Arumugaswami V, Chew KW, Lewis MJ. A new system to measure and compare hepatitis C virus replication capacity using full-length, replication competent viruses. J Virol Methods. 2013 Dec; 194(1-2):82-8. PMID: 23973740.
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    29. Chu D, Ren S, Hu S, Wang WG, Subramanian A, Contreras D, Kanagavel V, Chung E, Ko J, Amirtham Jacob Appadorai RS, Sinha S, Jalali Z, Hardy DW, French SW, Arumugaswami V. Systematic analysis of enhancer and critical cis-acting RNA elements in the protein-encoding region of the hepatitis C virus genome. J Virol. 2013 May; 87(10):5678-96. PMID: 23487449; PMCID: PMC3648135.
    30. Suhane S, Kanzaki H, Arumugaswami V, Murali R, Ramanujan VK. Mitochondrial NDUFS3 regulates the ROS-mediated onset of metabolic switch in transformed cells. Biol Open. 2013 Mar 15; 2(3):295-305. PMID: 23519235; PMCID: PMC3603411.
    31. Khachatoorian R, Arumugaswami V, Raychaudhuri S, Yeh GK, Maloney EM, Wang J, Dasgupta A, French SW. Divergent antiviral effects of bioflavonoids on the hepatitis C virus life cycle. Virology. 2012 Nov 25; 433(2):346-55. PMID: 22975673; PMCID: PMC3478964.
    32. Khachatoorian R, Arumugaswami V, Ruchala P, Raychaudhuri S, Maloney EM, Miao E, Dasgupta A, French SW. A cell-permeable hairpin peptide inhibits hepatitis C viral nonstructural protein 5A-mediated translation and virus production. Hepatology. 2012 Jun; 55(6):1662-72. PMID: 22183951; PMCID: PMC3345309.
    33. Noh CW, Cho HJ, Kang HR, Jin HY, Lee S, Deng H, Wu TT, Arumugaswami V, Sun R, Song MJ. The virion-associated open reading frame 49 of murine gammaherpesvirus 68 promotes viral replication both in vitro and in vivo as a derepressor of RTA. J Virol. 2012 Jan; 86(2):1109-18. PMID: 22090108; PMCID: PMC3255801.
    34. Gonzalez O, Fontanes V, Raychaudhuri S, Loo R, Loo J, Arumugaswami V, Sun R, Dasgupta A, French SW. The heat shock protein inhibitor Quercetin attenuates hepatitis C virus production. Hepatology. 2009 Dec; 50(6):1756-64. PMID: 19839005; PMCID: PMC3846025.
    35. Arumugaswami V, Kumar PM, Konjufca V, Dienglewicz RL, Reddy SM, Parcells MS. Latency of Marek's disease virus (MDV) in a reticuloendotheliosis virus-transformed T-cell line. I: uptake and structure of the latent MDV genome. Avian Dis. 2009 Jun; 53(2):149-55. PMID: 19630217.
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    36. Arumugaswami V, Kumar PM, Konjufca V, Dienglewicz RL, Reddy SM, Parcells MS. Latency of Marek's disease virus (MDV) in a reticuloendotheliosis virus-transformed T-cell line. II: expression of the latent MDV genome. Avian Dis. 2009 Jun; 53(2):156-65. PMID: 19630218.
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    37. Gong D, Qi J, Arumugaswami V, Sun R, Deng H. Identification and functional characterization of the left origin of lytic replication of murine gammaherpesvirus 68. Virology. 2009 May 10; 387(2):285-95. PMID: 19285330; PMCID: PMC2715915.
    38. Arumugaswami V, Sitapara R, Hwang S, Song MJ, Ho TN, Su NQ, Sue EY, Kanagavel V, Xing F, Zhang X, Zhao M, Deng H, Wu TT, Kanagavel S, Zhang L, Dandekar S, Papp J, Sun R. High-resolution functional profiling of a gammaherpesvirus RTA locus in the context of the viral genome. J Virol. 2009 Feb; 83(4):1811-22. PMID: 19073723; PMCID: PMC2643748.
    39. Arumugaswami V, Remenyi R, Kanagavel V, Sue EY, Ngoc Ho T, Liu C, Fontanes V, Dasgupta A, Sun R. High-resolution functional profiling of hepatitis C virus genome. PLoS Pathog. 2008 Oct; 4(10):e1000182. PMID: 18927624; PMCID: PMC2564836.
    40. Sanchez DJ, Miranda D, Arumugaswami V, Hwang S, Singer AE, Senaati A, Shahangian A, Song MJ, Sun R, Cheng G. A repetitive region of gammaherpesvirus genomic DNA is a ligand for induction of type I interferon. J Virol. 2008 Mar; 82(5):2208-17. PMID: 18077715.
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    41. Arumugaswami V, Wu TT, Martinez-Guzman D, Jia Q, Deng H, Reyes N, Sun R. ORF18 is a transfactor that is essential for late gene transcription of a gammaherpesvirus. J Virol. 2006 Oct; 80(19):9730-40. PMID: 16973577; PMCID: PMC1617240.
    42. Santin ER, Shamblin CE, Prigge JT, Arumugaswami V, Dienglewicz RL, Parcells MS. Examination of the effect of a naturally occurring mutation in glycoprotein L on Marek's disease virus pathogenesis. Avian Dis. 2006 Mar; 50(1):96-103. PMID: 16617990.
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    43. Anobile JM, Arumugaswami V, Downs D, Czymmek K, Parcells M, Schmidt CJ. Nuclear localization and dynamic properties of the Marek's disease virus oncogene products Meq and Meq/vIL8. J Virol. 2006 Feb; 80(3):1160-6. PMID: 16414993; PMCID: PMC1346918.
    44. Shamblin CE, Greene N, Arumugaswami V, Dienglewicz RL, Parcells MS. Comparative analysis of Marek's disease virus (MDV) glycoprotein-, lytic antigen pp38- and transformation antigen Meq-encoding genes: association of meq mutations with MDVs of high virulence. Vet Microbiol. 2004 Sep 08; 102(3-4):147-67. PMID: 15327791.
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    45. Parcells MS, Arumugaswami V, Prigge JT, Pandya K, Dienglewicz RL. Marek's disease virus reactivation from latency: changes in gene expression at the origin of replication. Poult Sci. 2003 Jun; 82(6):893-8. PMID: 12817443.
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